Gene NvecPTP-sf4-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP059_AA protein Get Run
NvecP059_AA_0-188 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-186 1.3e-129 425.5 In-house 52-237 (237) alignment 
Range on Protein: 1-186
Range on HMM: 52-237/237.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQQ
|||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||.....|.|||.|||||||||||||.||||||
gplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqq

TAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
||||||||||||.|.|||.||||||||||||.||||||||||||||||||||||||||||.|||||||||||||||||||||||||
taallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPRD_pd Subfamily PTPRD 1-188 3.6e-85 281.7 In-house 98-281 (564) alignment 
Range on Protein: 1-188
Range on HMM: 98-281/564.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDqPAAYGVLTVSLKKKEEFSDYTVRSFTTfYRWTLKGVRLIHQYQFTSWPHRGVPQQ
|||.....|||.|||....|.||||| | | .. |||.|||... .. || |||.|...||..||..|.|.   . . . .| ..|..|||||..|||..
gPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpes

TAALLRFRKNIIDRPPhvPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
...||...... .  .  |..||...|||||.||||.|.||||||...||.|.||||.||. . ..|....||..||.|||..|||||
atslLdlirkvralne..pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal
subfamily_PTPRB_pd Subfamily PTPRB 1-187 1.3e-66 219.6 In-house 101-284 (293) alignment 
Range on Protein: 1-187
Range on HMM: 101-284/293.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYrwtLKGVRLIHQYQFTSWPHRGVPQQ
||| .. ||||.|||..|.|.||||| |.|.   ||..|||....| .|| ..|.|...|| .|...|...       |  | ..||.|||||  |||..
GPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPek

TAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
|..||.| ... ..  .  ...| ..|||||.||||.|. .| .|.. .|. .|||.  |... |.| ...||..||.||||..|. 
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
0046845 (Phosphotyrosine protein) phosphatases II 1-187 2.1e-65 216.3 In-house 84-273 (284) alignment 
Range on Protein: 1-187
Range on HMM: 84-273/284.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQQ
|||.....|||.|||.....||||||.|.| .  ||.||||.....  || .|| |...|...||||| ..  .  . . .| ......||||..|||..
gPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps

TAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKK---VVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.. ||.| . . .  ...| .|| ..|||||.|||| |...| .|.| ....   .||....|. . | ||. .|| .||.|.....||.
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1-188 1.1e-64 213.5 In-house 96-280 (318) alignment 
Range on Protein: 1-188
Range on HMM: 96-280/318.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPAAYGVLTVSLKKKEEFSDYTVRSFTTfYRWTLKGVRLIHQYQFTSWPHRGVPQQ
.||   ..|||.|||. ...|||||| . |    |.|.|||| ... .|| |.| ||.. |.|||..|.|.   |   . .| ..||..|||| .|||..
aPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kgsrsygklvvelkeevelsdyvlrefkv.trteeeesrqvrqyhytsWpdegvpes

TAALLRFRKNIiDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
.| || . ... ..  . .. || ..|||||.||||.|...|..|...|. ..||....|. . | |. ..||.|||.||....||||
gaslldlvrqv.skaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal
0051299 (Phosphotyrosine protein) phosphatases II 1-188 1.3e-64 213.8 In-house 99-286 (288) alignment 
Range on Protein: 1-188
Range on HMM: 99-286/288.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRW---TLKGVRLIHQYQFTSWPHRGV
|||.....|||.|||.....||||||.|.| .  ||.||||. ...  || .|| |.. |...||||| ..  .       . .| ......|.||. ||
gPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

PQQTAALLRFRKNIIDRPPhvPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
|. . .||.| . ...  .  . .|| ..|||||.|||| |...| .|.| .....||....|. . | ||...|| .||.|.....||.|
pdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 1-187 2e-64 213.2 In-house 115-298 (308) alignment 
Range on Protein: 1-187
Range on HMM: 115-298/308.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST--DQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLkGVRLIHQYQFTSWPHRGVP
|||.....|||.|||.....|||||| |.| .  ||.||||..  ...  || .|| |.. |...||||| ..  .  .   .| ......|.||. |||
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvP

QQTAALLRFRKNIIDRPphvpESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.....||.| . . ..     ..|| ..|||||.|||| |...| .|.| .... ||....|. . | ||. .||..||.|.....|| 
pspeilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-188 3.4e-61 201.6 In-house 59-242 (250) alignment 
Range on Protein: 1-188
Range on HMM: 59-242/250.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELkCHQYWPsTDQPAAYGVLTVSLKKKEEFSDYTVRSFTTfYRWTLKGVRLIHQYQFTSWPHRGVPQQ
|||...  |||.||..|| ..||||| | | ..  .||||| ....  || .||||..||||.|||.| .    . . .. |.. |..|..|| .|||..
gPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.vekaekyGdvtvsllskeefadytkrklkl.skakkaderivrqlhfvvWPdkgvPev

TAALLRFRKNIIDRPPHVpESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
. | | ..|..    ... ...| |..||||.||.| |..|||.| ..|..||||...... . .|||  .....||||... ||.||
atavLellkkvqasqqqa.gnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
0036941 (Phosphotyrosine protein) phosphatases II 1-187 4.7e-61 202.0 In-house 85-276 (297) alignment 
Range on Protein: 1-187
Range on HMM: 85-276/297.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPAAYGVLTVSLKKKEE--FSDYTVRSFTTFYRwTLKGVRLIHQYQFTSWPHRGV
|||.....|||.|||.....|||||| |.| .  ||.||||.. ...  || .|| |.. |.  ..|||.| ..  .    . .| ......|.||. ||
gPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgv

PQQTAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAK---EKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
|. .| ||.| . . .. .. |..|| ..|||||.||.| |...| ||.| .   . . |||...|... | || ..|| .||.|.....|| 
pespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-186 5.7e-61 201.1 In-house 97-277 (288) alignment 
Range on Protein: 1-186
Range on HMM: 97-277/288.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFyrwTLKGVRLIHQYQFTSWPHRGVPQQ
||| .. .|||..|...| | |||||.|.||.. ||..|||..|.|  || .|| |....|  |...|..        |. . |.|||...||  |||..
gPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPes

TAALLRFRKNIiDRpPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.| || ..... .   .  ..|| |.|||||.||||.|...||.. . .|....|. . |. . . |. ..||. ||.||....|.
kapllellrqv.kv.anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0047943 (Phosphotyrosine protein) phosphatases II 1-187 1.1e-60 200.7 In-house 84-271 (273) alignment 
Range on Protein: 1-187
Range on HMM: 84-271/273.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQ--PAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKgVRLIHQYQFTSWPHRGVP
|||.....|||.|||.....|||||| |.| .  ||.||||.. .  .  || .|| |.. |...||||| ..  .  | . .| ......|.||  |||
gPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvp

QQTAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.... ||.| . . .   ..|..|| ..|||||.|||| |...| .|.| .... ||....|. . . ||...|| .||.|.....|| 
pslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1-186 3.3e-60 198.8 In-house 96-281 (305) alignment 
Range on Protein: 1-186
Range on HMM: 96-281/305.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQ-PAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQ
|||..  .|||.....|| |.|||||.|.||.. ||.|||| . . .  .| ..| || ....|||. | ..   . . |  | . |||.|.||  ||||
gPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpq

QTAALLRFRKNIIDRppHVPESG-PWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
....||.. |..  .  .  . | | ..|||||.||||.|...| .| ..|. .|||...... . . |....||.|||||.|. . |
fatsllslikrvqkd..qkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-187 3.8e-60 198.6 In-house 98-282 (319) alignment 
Range on Protein: 1-187
Range on HMM: 98-282/319.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTdQPAAYGVLTVSLKKKEEFSDYTVRSFTTfyRWTLKGV--RLIHQYQFTSWPHRGVP
.|||   .|||.|||.|..|..||||.| |  ..|...|||.. ..  || |.| |...|| .|| .| ..   .     |  | . ..|.|.||  .||
aPlentiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklkl..nkkssevetRevkhfqyteWpdhdvP

QQTAALLRFRKNIiDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
... .|| . |.|  .  . ..||| ..|||||.|||| |.|.|||| . ||  |.|....|  .   |. ..|...|| ||....|||
ekatslldllkri.rksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
0045450 (Phosphotyrosine protein) phosphatases II 1-187 5.1e-60 199.1 In-house 114-303 (307) alignment 
Range on Protein: 1-187
Range on HMM: 114-303/307.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQQ
|||.....|||.|.|.....||||||.|.| .  ||.||||.....  || .|| |...|. ..|||| ..  .    . .| ......|.||. |||. 
gPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps

TAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKV---VDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.. ||.| . . .   . |..|| ..|||||.|||| |.... |||| .. ..   ||... |. . | || ..|. .||.|... .|| 
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 1-188 9.3e-59 194.6 In-house 93-276 (317) alignment 
Range on Protein: 1-188
Range on HMM: 93-276/317.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRwTLKGVRLIHQYQFTSWPHRGVPQQ
|||.....|||.|||.....|||||| | | .  ||.||||. ...  || .|| |.. || ...|.| ..  .    . .| ......|.||. |||. 
gPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvpps

TAALLRFRKNIIDRPPhvPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
.  ||.| . . .  .  ...|| ..|||||.|||| |.... ||.| .... ||... |. . | ||...|| .||.|... .|| |
pdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0043336 (Phosphotyrosine protein) phosphatases II 1-186 1.3e-57 190.7 In-house 95-275 (278) alignment 
Range on Protein: 1-186
Range on HMM: 95-275/278.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPstDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYrWTLKGVRLIHQYQFTSWPHRGVPQQ
|||.....|||.|||......|||||.| | .  ||.||||  ...  || .|| |.| |...||||| ..  .    . .| ...|....||. ||| .
gPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpes

TAALLRFRKNIIDRPPhvPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.. ||.| | .... .  ...|| ..|||||.|||| |.... .|.|..  . ||... |. . | || ..|| .||.|... .||
lsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 1-187 2.2e-57 190.1 In-house 108-288 (297) alignment 
Range on Protein: 1-187
Range on HMM: 108-288/297.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNElKCHQYWPSTDQpaAYGVLTVSLKKKEEFSDYTVRSFTTFYrwtLKGVRLIHQYQFTSWPHRGVPQQ
|||.....|||.|||.....|||||| |.| .  ||.||||.. .   || .|| |.| |. ..|||| ..  .    . .| ....|.|.||. |||. 
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvpps

TAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.. ||.| . . ..  . |..|| ..|||||.|||| |.... ||.| .... ||... |. . | ||...|| .||.|... .|| 
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_PTPN6_pd Subfamily PTPN6 1-185 2.8e-57 189.1 In-house 105-294 (306) alignment 
Range on Protein: 1-185
Range on HMM: 105-294/306.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQQ
| ||.   |||.|||||.. ||||.|  .| .. || .|||.. .  .||...|.  .... .||..|...   ... |  | ..||.|.|||  |||..
gclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkd

TAALLRFRKNIIDRPPHVP--ESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKV---VDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
. |.| | ...  .  ..   |.|| ..|||||||||| |.|||..|.. ..|..   .||.. |.|. | |  ..||..|| |....| 
pgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_PTPRG_pd Subfamily PTPRG 1-188 3e-57 189.1 In-house 98-287 (563) alignment 
Range on Protein: 1-188
Range on HMM: 98-287/563.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFY---RWTL--KGVRLIHQYQFTSWPHR
|||.. .||||.|.|... ..|||.| | | .  ||..|||. |..  ||.|.| |...| .. ||||...      . .   . ..|. ||..|.||  
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdh

GVPQQTAALLRFRKNIidRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
|||....  | | |       .  | || ..|||||.||||...|.|..|.| .....|.... .. |.  |....||..||.|.|...|||.
gvPehslpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai
Y_phosphatase Protein-tyrosine phosphatase 1-186 5e-57 188.4 Pfam-A 49-235 (235) alignment 
Range on Protein: 1-186
Range on HMM: 49-235/235.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWP-STDQPAAYGVLTVSLK-KKE-EFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGV
|||.|...|||.||||||..|||||| | | .. ||.|||| .....  || ..| || |.. . ..||.| ..   . . .  | ..|...|.||..||
gPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgv

PQQTAALLRFRKNIIDRPphVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
|... .||.. ...  .    ..||| ..|||||.||||.|...|..|.|..... ||....| .. . || ..|. .||.|....|||
pespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1-186 5e-57 188.4 In-house 49-235 (235) alignment 
Range on Protein: 1-186
Range on HMM: 49-235/235.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWP-STDQPAAYGVLTVSLK-KKE-EFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGV
|||.|...|||.||||||..|||||| | | .. ||.|||| .....  || ..| || |.. . ..||.| ..   . . .  | ..|...|.||..||
gPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgv

PQQTAALLRFRKNIIDRPphVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
|... .||.. ...  .    ..||| ..|||||.||||.|...|..|.|..... ||....| .. . || ..|. .||.|....|||
pespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPRA_pd Subfamily PTPRA 1-186 1.1e-56 187.1 In-house 108-293 (330) alignment 
Range on Protein: 1-186
Range on HMM: 108-293/330.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPAAYGVLTVSLKKKEEFSDYTVRSFTTF---YRWTLKGVRLIHQYQFTSWPHRGV
||.| . .|||.|.|. | . ||||| | | .| ||.||||. .   .|| ..|.......  ||||| |           | .||..|. |||||. ||
GPkeetvedfwrmiweqksativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv

PQQTAALLRFRKNIIDRPPHvpESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
| ..  .|.. |..    .   ..|| ..|||||.|||| |.|.||.| . | ...||... |...   || ..||. ||.||....||
PfepiGmlkllkkvkklnqq..sagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_PTPRK_pd Subfamily PTPRK 1-187 1.2e-56 186.8 In-house 93-276 (314) alignment 
Range on Protein: 1-187
Range on HMM: 93-276/314.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPaaYGVLTVSLKKKEEFSDYTVRSFTTFY-RWTLKGVRLIHQYQFTSWPHRGVPQ
|||..   |||..|..|.|. ||||| |.|   .|| .|||   .   || . | | . |  ... || |.      . ...|...|.||..||. .||.
gPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPv

QTAALLRFRKNIIDRPPHvpESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.  .||.. ...    ..  | |. ..||||| ||||.|..|| .|  .....|||..| |... . .. ...|..||.||.. ||||
satgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
0040439 (Phosphotyrosine protein) phosphatases II 1-186 3.8e-56 185.8 In-house 61-244 (249) alignment 
Range on Protein: 1-186
Range on HMM: 61-244/249.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRwTLKGVRLIHQYQFTSWPHRGVPQQ
|||.....|||.|.|.....|||||| | | .  ||.||||. ...  || .|| |.. |...||||| ..  .    . .| ....|.|.||. |||. 
gPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvpps

TAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.. ||.| . . .   . |..|| ..|||||.||||.|.... ||.| .... ||....|. . . ||...|. .||.|... .||
fedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-188 1.8e-55 183.0 In-house 91-276 (281) alignment 
Range on Protein: 1-188
Range on HMM: 91-276/281.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSFTTfYRWTlKGVRLIHQYQFTSWPHRGVPQQ
||. .|...||||||..| |.|||.|  ||.. ||||.|||  ..   || .||. ...|| . |  | |.  .| .    | ..| ..|.||  |||..
gPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eres.getreveqlaytaWPdhGvPat

TAALLRFRKNIIDRPpHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKE-KKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
|..|| |||..     .  .  | .||||||.|||| .. .| ....... .. .|. . |... ..| ...||  || |.....|.||
tkellefrkevlklt.ekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
DSPc_SM00195 1-187 2.4e-55 183.0 In-house 76-261 (263) alignment 
Range on Protein: 1-187
Range on HMM: 76-261/263.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPAAYGVLTVSLKKKEEFS-DYTVRSFTTFYRWTlKGVRLIHQYQFTSWPHRGVP
|||.| ..|||.|||.||...|||||   | .. ||..|||.. ...  .| ..| |...|. . ....| ..  .  . .  | ..|||...||..|||
gPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvp

QQTAALLRFRKNIIDRPPHVpeSGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
..|  .|.. . .  .  .   ||| ..|||||.||||.|..|| .|.. .|.| ||| . | .. . || ..||..|| ||...|||.
dstksvlellravkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 1-187 2.4e-55 183.0 In-house 76-261 (263) alignment 
Range on Protein: 1-187
Range on HMM: 76-261/263.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPAAYGVLTVSLKKKEEFS-DYTVRSFTTFYRWTlKGVRLIHQYQFTSWPHRGVP
|||.| ..|||.|||.||...|||||   | .. ||..|||.. ...  .| ..| |...|. . ....| ..  .  . .  | ..|||...||..|||
gPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvp

QQTAALLRFRKNIIDRPPHVpeSGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
..|  .|.. . .  .  .   ||| ..|||||.||||.|..|| .|.. .|.| ||| . | .. . || ..||..|| ||...|||.
dstksvlellravkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-188 4.8e-55 181.6 In-house 94-277 (315) alignment 
Range on Protein: 1-188
Range on HMM: 94-277/315.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS-TDQPAAYGVLTVSLKKKEEFSDYTVRSFttFYRWTlKGVRLIHQYQFTSWPHRGVPQ
|||..| ||||.||.||| . |||.| . ||. .|| ||||    . . .| . |.| . |  .| ..| .    | . .  | . |.||| ||..||..
gPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrks.eesrtvtqfqftewPdkGvdk

QTAALLRFRKNIIDRppHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
||..||.. |..     . ..  . ..|||||.||||... || .. |.|....||..|.|. . ..|||..||...| ||....|| |
qtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
0045098 (Phosphotyrosine protein) phosphatases II 1-186 1.3e-54 180.8 In-house 71-270 (278) alignment 
Range on Protein: 1-186
Range on HMM: 71-270/278.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYR----WTLKgVRLIHQYQFTSWPHRG
|||.| ..|||.|.|.....||||||.|.|..  ||.||||. ...  || .|| |.. |...|||.| ..  .      .|.  | ........||  |
gPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredle.srgvthlhylpwpdhg

VPQQT--AALLRFRKNIIDRPP-----------HVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAkeKKVVDIYNYVHSIEEDRPY-IIQTKDQYVFIHQ
|| ..  . .|.. . | ..             . ...|| ..|||||.|||| . ... ||..   ...||....|. . . ||. ..|...||.|...
vpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflye

TILE
 .||
flle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1-188 2.4e-54 179.3 In-house 93-276 (515) alignment 
Range on Protein: 1-188
Range on HMM: 93-276/515.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS-TDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTlkgVRLIHQYQFTSWPHRGVPQ
||...| ||||..|.||. . |.|.| | ||.  || .|||    .   .| . |.|   |  .. . | .|         .| . |..|| ||..|||.
gPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpk

QTAALLRFRKNIIDRppHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
.| .||.. |..     |   . | |||||||.||||... || .. .||. ..||..|.|. | ..|||..||..|| ||....|| |
htssllklikevkad..hgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
0042113 (Phosphotyrosine protein) phosphatases II 1-186 3.6e-53 175.8 In-house 59-241 (245) alignment 
Range on Protein: 1-186
Range on HMM: 59-241/245.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYrWTLKGVRLIHQYQFTSWPHRGVPQQ
|||.....|||.|.|......||||| . | .  ||.||||. ...  || .|| |.. | ..||||| ..  .    . .| ...|....||. |||  
gPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtn.lgddesrevihyhylpwpdhgvpdl

TAALLRFRKNIIDRPPHvPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.. ||.| . . .     ...|| ..|||||.|||| |.... ||.|... . |.... |. . . || ..|| .||.|... .||
lellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN3_pd Subfamily PTPN3 1-187 3.8e-53 175.2 In-house 91-274 (280) alignment 
Range on Protein: 1-187
Range on HMM: 91-274/280.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRwTLKGVRLIHQYQFTSWPHRGVPQQ
|||.... |||||||..|.|.||||| |.|    |||||||.|..   || ..| ..|..| . | .| ..   . . |  | |.| |...||  |||..
GPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdk.etkeerkilqlqylaWpdhgvPdd

TAALLRFRKNIidRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.| .|.| ...  |  .  .. | ..||||||||||......  |    ... | . . |. . . |  ..||..|| |. ..||..
sadflefverv..rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-187 2e-52 173.1 In-house 99-278 (315) alignment 
Range on Protein: 1-187
Range on HMM: 99-278/315.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPstDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRwtlKGVRLIHQYQFTSWPHRGVPQQ
||. .| .|||..|..|... |||||.|.||.. |. .|||  |.   || .||..|..| ...||||.... ..   . .| . |...||||  |||. 
gpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp..dkkviyGkitvtrkseevnteytvrtlsvvfg...dnirevvqlhytswpdmgvpky

TAALLRFRKNIIDRppHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
| .|. . ...     |  . |. ..|||||.|||| |. .||.| ||. ....|.||... . . |  ..|. .|| ||....||.
tiplmnlirtvkqh..htnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
0037934 (Phosphotyrosine protein) phosphatases II 1-186 1.2e-51 171.0 In-house 51-240 (243) alignment 
Range on Protein: 1-186
Range on HMM: 51-240/243.0
GPLESSCDD----FWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPstDQPaAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRG
|||.....|    ||.|.|.....|||||| |.| . .||.||||  ..   || .|| |.. |...||||| ..  .  . . .||...|....||. |
gPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhg

VPQQTAALLRFRKNIIDRPPH------VPESGPWIIHCSAGIGRTGIFLVIDAMLRQAkekKvVDIYNYVHSIEEDRPY-IIQTKDQYVFIHQTILE
||. .. ||.| . ...           ...|| ..|||||.|||| ..... ||..    . ||....|. . | ||. ..|| .||.|... .||
vPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1-185 4e-51 168.7 In-house 80-265 (274) alignment 
Range on Protein: 1-185
Range on HMM: 80-265/274.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP---AAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTlkgVRLIHQYQFTSWPHRGV
||| .  .|||.|..||...|||||| | | || ||..|.| . .      || . .  .|. |  ||.||...  |       | .. | .|.|| . .
GPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhks

PQQTAALLRFRKNIIDRPPHVPES-GPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
|... .||.. ... .   .  .  .| ..||||||||||.|. |.  .|| .|..|||. . |  .  ||  ..||..|| .||... 
PddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_PTPN9_pd Subfamily PTPN9 1-186 2.1e-50 166.4 In-house 92-288 (297) alignment 
Range on Protein: 1-186
Range on HMM: 92-288/297.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWP-STDQPAAYGVLTVSLKKKEEFSDYTVRSFTTfYRWTLKGVRLIHQYQFTSWPHRGVPQ
|||.  ..|||.|||.... |||| | ..|   ||| |||| .... | .| |.||  . || .||.||...  .. . .  | .  .||.|||  |||.
GplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvlei.knvkteesrkvthfqflsWPdyGvPs

QTAALLRFRKNI-----------IDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
..|.|| .....            |.    |.  | ..|||||||||| |  .|  | . .|. .||. . |. . . | . ||| .||.| ....||
saaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-186 4.3e-49 162.5 In-house 111-289 (319) alignment 
Range on Protein: 1-186
Range on HMM: 111-289/319.0
GPLESSCDDFWQMVWQEKCSVIVMLTgliegnELKCHQYWPSTdQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQQ
|||. . .|||.|.|. .|| ||.||      . || ||||       ..   |...  || ..|.||..        |..| |.|. |  ||. |||..
GPldntladfWrmiweyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy

TAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.. |.|. |..     .  .  . ..|||||.||||...|.|..| . ||.| ||.||.|. . ..|. ..|   || ||. ..||
psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN13_pd Subfamily PTPN13 1-188 8e-49 161.3 In-house 84-269 (273) alignment 
Range on Protein: 1-188
Range on HMM: 84-269/273.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQ-P-AAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTlKGVRLIHQYQFTSWPHRGVP
|||  ...|||||||. |..||.|.|   |....|||.|||.. . .  ... |.|.| | .. ....||...     . . .| . . .|..||  |||
GPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvP

QQTAALLRFRKNIidRPPHVpESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
...| ||.| ...  |  .  ..|| ..||||||||.|....||..|   . .| .|. . |... | |  ..||||||.|....|||.|
ssaaellqfvaev..rrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-187 1.7e-48 160.0 In-house 98-282 (290) alignment 
Range on Protein: 1-187
Range on HMM: 98-282/290.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAaYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRG-VPQ
||...   |||...||||...|||||  || .. ||.||||..|. | ||  .. | . |....|. | .    . . .  . ..|||.|.|.. | |..
gpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtn

QTAALLRFRKNIidRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
... || ... .  .  . .  .. ..|||...||...|....  . ..| . |.|... ..|    .|  .||..|| .|.| .|..
pqtillvieemy..ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-186 1.8e-48 160.5 In-house 75-253 (284) alignment 
Range on Protein: 1-186
Range on HMM: 75-253/284.0
GPLESSCDDFWQMVWQEKCSVIVMLTgliegnELKCHQYWPSTdQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQQ
|||. . .|||.|.|. .|| ||.||      . || ||||       ..   |...  || ..|.||..        |..| |.|. |  ||. |||..
GPldntladfWrmiweyncstivllt......kdkcsqywplk.ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdy

TAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.. |.|. |..     .  .  . ..|||||.||||...|.|..| . ||.| ||.||.|. . ..|. ..|   || ||. ..||
psdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN12_pd Subfamily PTPN12 1-186 6.7e-48 158.0 In-house 90-275 (290) alignment 
Range on Protein: 1-186
Range on HMM: 90-275/290.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD-QPAAYGVLTVSLKKKEEFS-DYTVRSFTTFYRwtlKGVRLIHQYQFTSWPHRGVP
|||    ||||.|.|. . ...||.  ..| .  ||..|||..  ..  .| ..|.|.... .. |...|...   .   |  | ..|...|.|| .|||
gPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvP

QQTAALLRFRKNIIDRPPhvPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKV---VDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
...  ||.. ... ..     |. | ..|||||.||||. ..|| . .. |..|.   .|... | .. ..|. ..|||.||........|
ssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_Ptp69D_pd Subfamily Ptp69D 1-186 1.2e-47 157.5 In-house 98-284 (307) alignment 
Range on Protein: 1-186
Range on HMM: 98-284/307.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTdQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRW----TLKGVRLIHQYQFTSWPHRG
.|.|.  .|||.|... .  .||||. | | |. ||..|||   .   || . | | ..|. |||. |..           ..  | . ||..|.|.   
dPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDsk

VPQQTAALLRFRKNIIDRPPHVpeSGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
||... .||.. ... . . .    .| ..||||| ||.|||. .| .| | |. . |||.. |. . ..|. ..|  .||||... .|.
vPevargllklieqvrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralld
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-186 1.1e-46 154.0 In-house 82-264 (283) alignment 
Range on Protein: 1-186
Range on HMM: 82-264/283.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQpAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQQ
.||.    |||.||..|| . ||||| | |... || ||||.      || .||.|.|      .... ..  .  . |   |.  ||.  | . |    
sPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqai

TAALLRFRKNIIDRPPHvpESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
  .|..| | |  .  .  . || ..|||.|||||..|. . | . .|. . |||... |. . |.|. ..||.||| ..|. .||
inslvkfnkvislqtes..kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-187 2.3e-45 149.8 In-house 93-277 (287) alignment 
Range on Protein: 1-187
Range on HMM: 93-277/287.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQpAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRG-VPQ
.|. .   .||....... ..||||. . | .| .|.||||...    .|  ...| ..|  ..|..| .    .   .  . ..|||.|.|. .| |..
sPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvte

QTAALLRFRKNIidRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
. . || . . .  .  . .  .. ..|||...||...|. ..  ....|.  |.|... ..|    .|  .|| .|| || . .|| 
pqtillvieemy..ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_PTPN1_pd Subfamily PTPN1 1-186 1.1e-44 147.4 In-house 78-269 (290) alignment 
Range on Protein: 1-186
Range on HMM: 78-269/290.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQ--PAAYG--VLTVSLKKKEEFSDYTVRSFTTFYrWTLKGVRLIHQYQFTSWPHRG
||| . .| ||||||..|.  .|||  ..| ...||.||||. ..     .    |.| | ..|. | |||| .      . .  | | .. .|.||  |
GPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen.lktqetreilhfhyttwpdfg

VPQQTAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKV---VDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
||.  ||.|.|  .. .    ... || .|||||||||.| | ..|..| . ..|.    ||| . .  . . |  .|||.||  | ...|||
vpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0051429 (Phosphotyrosine protein) phosphatases II 1-187 1.5e-44 148.0 In-house 29-224 (272) alignment 
Range on Protein: 1-187
Range on HMM: 29-224/272.0
GPLESSCDDFWQMvWQEKCSVIVMLTGLIEGNELKCHQYWP-----------STDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQF
|||. ...|||.. .......||.|... | . |||..|||           .....  || |.| | ..| ..||..| ..  . .. . .| ......
gplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhy

TSWPHRGVPQQTaaLLRFRKNIIDrpphvpeSGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVD--------IYNYVHSIEEDRPYIIQTKDQYVFIH
|.|| .||||..  ||.. . . |       .|| ..|||||..|||.. ... .|..  .  .||        ....|. . . ||...|| .||.|..
tdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

QTILEA
. .||.
eallel
subfamily_PTPN23_pd Subfamily PTPN23 1-187 2.6e-43 142.9 In-house 90-279 (288) alignment 
Range on Protein: 1-187
Range on HMM: 90-279/288.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS-TDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRwTLKGVRLIHQYQFTSWPHRGVPQ
.||.|.  |||.||...| ||||||.   | .. |...|||. ....  .| |.|.||...| . .  | ..   .   . |. .   |.||||. |||.
aPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl.dadavksvshlqltsWpelGvPa

QTAALLRFRKNIID--RPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKE-KKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
    ||.| ... .  .  . .   | ..|||||.||||.| .. | .|. .. . ..|| . |. . |.| . .|.|.|. |  . .|||
sPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-188 9.7e-42 137.7 In-house 95-236 (392) alignment 
Range on Protein: 1-188
Range on HMM: 95-236/392.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNelkchqywpstdqpaaygvltvslkkkeefsdytvrsfttfyrwtlK--GVRLIHQYQFTSWPHRGVP
||  .| ||||.||.||. . |.|.| | ||.                                              |   .| . |..|| || ..||
gpnaaslddfwrmvfqenvttiamvtklkegd..............................................kgddartvaqfhftewPdkdvp

QQTAALLRFRKNIidRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
..|..||.| |..  .  .   . | |||||||.||||. . ||... .||. ..||..|.|  | . |||..|||.|| ||. ..|| |
khtssllkfikev..kadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1-186 3.4e-41 136.0 In-house 71-262 (270) alignment 
Range on Protein: 1-186
Range on HMM: 71-262/270.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP---AAYGVLTVSLKKKEEFSDYTVRSFTTFyRWTlKGVRLIHqYQFTSWPHRGV
|||...  .||.|.|.|| . |||.||| | .  || .|||.  .     ..| ..|   ..|  . | ..  .   ..  .  ||.| .....|| .||
gPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekg.eerrlvH.fwyntWpdhgv

PQQTA------ALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
|...        ||.  ...     .  ...|...|||||.||||.....| ..|  .|.| ||. . .. . .||. ..|. .|| |......|
preedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1-186 6.5e-40 131.7 In-house 92-291 (301) alignment 
Range on Protein: 1-186
Range on HMM: 92-291/301.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD-QPAAYGVLTVSLKKKEEFSDYTVRSFTT--------------FYRWTLKGVRLIH
||...   |||...|||| . |||.|.| || . ||.||||... .   .| .|| |...  . |...|...               |   . |  . . 
gpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvl

QYQFTSWPHRGVPQQTAALLRFRKNIIDRPPHvPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
|.| |.||. || .. .  |.   ..| |    .. || ..|||....|.|..  ..  | |.|   |||... ....   .|  ..| .||..|.. | 
qlqvtdWpqdGvvreprtvLqviddvihrqqk.igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid

E
.
m
subfamily_PTPRN_pd Subfamily PTPRN 1-186 8.7e-40 131.3 In-house 107-290 (297) alignment 
Range on Protein: 1-186
Range on HMM: 107-290/297.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQpAAYGVLTVSLKKKEEFS-DYTVRSFTTfYRWTLKGVRLIHQYQFTSWPHRGVPQ
||| |.  |||||||.. . |||.|| | | .  .|..||| . . . |..  | |  .  .. || ||||        .  | . |. | |||..||| 
gplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGs.evyhiyevhlvsehiwcddylvrsfyl.knlqtsetrtvtqfhflswpeegvPa

QTAALLRFRKNIIDrpPHVPESGPWIIHCSAGIGRTGIFLVIDAMLR-QAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.. .|| ||. .     .   | | ..|||.| ||||....|| .|   .|  | .||   .  . ..|| ...||||. |. ... |
saksllefrrkvnk..syrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN14_pd Subfamily PTPN14 1-186 6.4e-39 128.7 In-house 100-294 (300) alignment 
Range on Protein: 1-186
Range on HMM: 100-294/300.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST---DQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTlKGVRLIHQYQFTSWPHRGV
||||  . |||||||... ..|||||  .|.   |...|.|..    . . .|   |. | .|. . .. ....  .  . |  | ..  |.| || .||
gPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlps.keertvwhlqytDWpdhgv

PQQTAALLRFRKNIIDRPPHVP-------ESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
|.     | . ...     ..        .. | ..|||||.||||. .. | ..   .  ...|| . .. . | | ...||  || |.......
PeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-184 2.3e-36 120.1 In-house 87-273 (287) alignment 
Range on Protein: 1-184
Range on HMM: 87-273/287.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYGVLTVSL-KKKEEFSDYTVRSFTTFYRWTlKGVRLIHQYQFTSWPHRGVPQ
||. ..  |||..|.... ......|  .|   |||..|||  ..|   |  .| | ...    .|.||..      | .  |...|... ||| .... 
gPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaP

QTAALLRFRKNI---IDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTI
 . .|.||  ..   |.      | || ..|...||||.||.| . ..... ..   ||. . |  . | |  ..|.  |. .. ...
tavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
0046846 (Phosphotyrosine protein) phosphatases II 1-186 4e-33 110.0 In-house 30-171 (176) alignment 
Range on Protein: 1-186
Range on HMM: 30-171/176.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStdqPAAYGVltvslkkkeefsdytvrsfttfyrwtlkgvrlihQYQFTSWPHRGVPQQ
|||.... ||..|.........|.|| ..| . |||..|||      ..|.                                  ||... ||  |||. 
gplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi..................................qylhlpwpDhgvpdl

tAALLRFRKNIIDrppHVPESGPWIIHCSAGIGRTGIFLVIDAMLRqakeKKVVDIYNYVHSIEEDRP-YIIQTKDQYVFIHQTILE
 ..||.. . | .   .. | || ..|||||||||| ..... . .    .| ..... .. . | || ...|| .|| |... .|.
.elllellefire...alkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefell
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1-186 8.3e-33 108.7 In-house 89-275 (307) alignment 
Range on Protein: 1-186
Range on HMM: 89-275/307.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD-QPAAYGVL--TVS---LKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPH
||||..  .|| |. |||   ..||  .||  ..||.||||  . |  ..|    |.|   |  |.   |  .   ||.     .. | |...|.. || 
gplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpd

RGVPQQTAALLrfrkNIIDRPphVPESGPWIIHCSAGIGRTGIFLVI----DAMLrqaKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
|||||   . .    |...      .  | ..|||||.||.|  . |    | |.   . .   |. . |. . ..|.| |||. ||...|. .||
rgvpqinltai....nlleav..rydtnpvvvhcsaGvGrsGtivaislvqdkmi...aGinckdmkklveelrsqrhyaiqteaqylylhrvlle
0041856 (Phosphotyrosine protein) phosphatases II 1-187 1e-32 108.6 In-house 41-170 (182) alignment 
Range on Protein: 1-187
Range on HMM: 41-170/182.0
GPLESSCDDFWQMVWQEKCSVIVMLTgliegnelkCHQYWPSTDqpaaygvltvslkkkeefsdytvrsfttfyrwtlkgVRLIHQYQFTSWPHRGVPQq
||| |.. ||..|........||.||         ...|||.                                       ||..||....||  |||  
gpllstvadflrmlkelgittivnlt.........eelywpell....................................erlgiqylylpwpDhgvpd.

TAALLRFRKNIIDrpphvpESGPWIIHCSAGIGRTGIFLVIDAMLRQakekKvVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.  ||.| . ...      |.|| ..|||||.|||| . ... |...    . |.... |. . . || ...| .||.|... .|| 
ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallel
0049260 (Phosphotyrosine protein) phosphatases II 1-182 1.4e-32 107.8 In-house 16-144 (152) alignment 
Range on Protein: 1-182
Range on HMM: 16-144/152.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWpstdqpaaygvltvslkkkeefsdytvrsfttfyrwtlkgvrlihQYQFTSWPHRGVPQQ
||.. ...|||.|... ....||||| | | ..|||.||.                                             ||... ||  |||. 
gpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwpDhgvpdl

TAALLRFRKNIIDRppHVPESGPWIIHCSAGIGRTGIFLVIDAMLrqakekKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
.  || . . |  .     ..|| ..|||||.|||| . ... ||      . |.....|  . | ||.......|. |...
sqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1-186 1e-31 104.7 In-house 101-281 (290) alignment 
Range on Protein: 1-186
Range on HMM: 101-281/290.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD-QPAAYGVLTVSLKKKEEFSDYTVRSFTT-FYRWTLKGVRLIHqYQFTSWPHRGVP
|.|...  |.|.|| ||| ..||||  |||    ||.||.| .. .  ..| .||   ....  . ...   .   . . |  .| | ..  ||| . |.
GalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkh.lkikswpdksva

QQTAALLRFRKNIIDrpphvpESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
. | ||||  . .         ||| ..|||||||||| |  |.. |.   . | .|. . | .. . |   .|   ||. . . .|.
lstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
0043147 (Phosphotyrosine protein) phosphatases II 1-182 2.7e-30 100.7 In-house 27-155 (172) alignment 
Range on Protein: 1-182
Range on HMM: 27-155/172.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLiegnelkchqywpstdqpaaygvltvslkkkeefsdytvrsfttfYRWTLKGVRLIHQYQFTSWPHRGVPqQ
||| . ..|||.|........||.||.|                                             . .. . .||. ||....||  |||  
gplrntladfwrmlkelgithivnltel.............................................lydpellerlgiqylylpwpDhgvp.l

TAALLRFRKNIIDRPpHVPESGPWIIHCSAGIGRTGIFLVIDAMLrqakekKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
.. ||.| . | ..  .. ..|| ..|||||.|||| . ... ||      . ..... |. . | ||...|...|| |...
lellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrflyy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1-186 1.8e-29 97.4 In-house 103-287 (305) alignment 
Range on Protein: 1-186
Range on HMM: 103-287/305.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP---AAYG--VLTVSLKKKEEfSDYTVRsfTTFYRWTLKG--VRLIHQYQFTSWP
|||. . |.|| || |.|   ||||   .|   ||| |||| .         |  |  ||  |  |  |  ..   |  . |  |     . . |.| ||
gpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpme.rdaeiq..itllnltysgdqkmsvrhlqwtewp

HRGVPQQTAALLRFRKNIidRPPHVpesgPWIIHCSAGIGRTGIFLVIDAMLRQ-AKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
 ||||    . | .   |  |  .|    | ..||||||||||  . |. .| . |..|..  . . |... ..| . ||.  ||.|||. .|.
drgvppckltslellsai..rgskv....pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1-180 3.2e-24 80.2 In-house 97-273 (301) alignment 
Range on Protein: 1-180
Range on HMM: 97-273/301.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWT--LKGVRLIHQYQFTSWPHRGV
|||.....||| |. | .   ||||.  .| .| ||..| |..  .    |  .. .|.||   .  .   |   . .      | .  ||...|..|||
gPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgv

PQQTAALLRFRkNIIDRpphvpESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFI
|.  | |  .  ... .        | ..||||||||.  |.  . . |. . .. ... . .. . |.|   .||. |  ..
Pkshaelfdlm.elvkk.....sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_ptpA1_pd Subfamily ptpA1 1-147 1.4e-23 78.3 In-house 96-255 (418) alignment 
Range on Protein: 1-147
Range on HMM: 96-255/418.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS---TDQPAAYGV-----LTVSLKKKEEFSDYTVRSFTTFYRWTLKG-VRLIHQYQFTS
|||  .  |||.|||...| .||||.   |   .|| .|||     .| . ||       | |..  |   |      |   | |..|  | | |||.  
gplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyeg

WPHRGVPQQTAALLRFRKNIIDRPPHV-PES---GPWIIHCSAGIGRTGIFLVIDAMLRQ
|| . .|..|  . .. ..| .|  .. | |    | |.|||||.|||| |     |...
wpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1-186 2.3e-23 77.3 In-house 88-267 (281) alignment 
Range on Protein: 1-186
Range on HMM: 88-267/281.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTdqpaAYGVLTVSlKKKEEFSDYTVRS--FTTFYRWTLKG-VRLIHQYQFTSWPHRGV
|| . .  |||.|.|||. . ||||  ..| |  || .|.|      |. .| .  |   .. | ||     ||    . .|  ||| .. .  ||   |
gpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn....ahcclqfd.klsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqv

PQQTAALLRFRKNIIDRpphvpeSGPWIIHCSAGIGRTGIFLVIDAMLRQAKEK-KVVDIYNYVHSI-EEDRPYIIQTKDQYVFIHQTILE
|. .  .|.  ..|  |      | | .||||||.||.| .. ..  |.  . .  . || . |  .    |   .|| .||..| . .|.
pessevmlkilrkirar......stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0049772 (Phosphotyrosine protein) phosphatases II 1-186 2.8e-23 78.6 In-house 91-278 (314) alignment 
Range on Protein: 1-186
Range on HMM: 91-278/314.0
GPLESSCDDF----------WQMV--WQEKCSVIVM---------------------LTGLIEGNelkchqywpstDQPAAYGVLTVSlkkkeefsD---
||||  ..||          |.||  .. .. .|||                     |..| ...           ..| |  . .          .   
gpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk........eely

----YtvrsfttfyrwtlkgVRLIHQYQFTSWPHRGVPqQTAALLRFRKNIIDRpphvPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEkKVVDIYNYV
    .                ||. .|  . .|  ..|  .. ...| . | .     .. || ..||.||.|||| |.|.. .... .   . .....|
dpelf...............erlgikylripvpDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedv

HSIeedRP-----YIIQTKDQYVFIHQTILE
...   ||       |.. .||.||.. .||
rlk...Rpinpnpgfieqleqyefilealle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1-111 4.7e-21 69.9 In-house 83-193 (297) alignment 
Range on Protein: 1-111
Range on HMM: 83-193/297.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYG----VLTVSlKKKEEFSDYTVRSFTTFYRwtlKGVRLIHQYQFTSWPHRG
|||... ||||..|...   ||||.. | |.   ||  ||||..|         |  .| .  .||    .  .. .||   .  | ..  || |||  |
GplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvvefls.stsdefdrviltelqliyr...sesrvvrhvqflswpdhG

VPQQTAALLRFRKNI
|| .   | ||. ..
vpsdledlvrfqaqv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1-186 1e-19 65.6 In-house 82-268 (285) alignment 
Range on Protein: 1-186
Range on HMM: 82-268/285.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPAAYGVLTVSLKK-KEE-FSDYTVRSFTTFYRWTLKGVR-LIHQYQFTSWPHRG
|||  .  |||.|..||| . ..||  |.||   ||  |.|    .   .|   ..| . |||  .   . ..|             . . |   || . 
gplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdql

VPQQTAALLRFRKNIIDRpphVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
 |...  .. . | .       |.  |  .|||||.|||  |. ||    .  |.  ... . |. .   |   .|.. |..|..  ..|
apedarpmielykwvkkv...npkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1-184 1.5e-19 64.7 In-house 101-286 (310) alignment 
Range on Protein: 1-184
Range on HMM: 101-286/310.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYGVLTVSL--KKKEEFSD--YTVRSFT-----TFYRWTLKGVRlIHQYQFTS
|||. .  |||.|..||..  |..|    |    ||  ||||     .||.. |.   .  |||     .|               ||..| .   ..  
gplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelr.vslikwpn

WPHRGVPQQTAALLRFRknIIDRPPHvpesGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTI
|| ||||..    .  |  .. .  |    || ..|||||..|... . ..  . .... . ||. . .  .  .|   |||. ||..|..  
wpdrgvpdekchtvpqr..llaqvrh....gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1-187 2.4e-19 64.2 In-house 89-275 (312) alignment 
Range on Protein: 1-187
Range on HMM: 89-275/312.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD------QPAAYGVLTVSLKKKEEF-SDYTVRSFTTFYRWTLKGVRLIHqYQFTSWP
||||..|  |||..    .. |..|.|..|    || .|           .   |      ..         | | .    . | .  .| | ||..|||
gplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnh.yqwaswp

HRGVPQQTAALLRFRKNIIDrpphvpESGPWIIHCSAGIGRTGIFLVIDAML---RQAKEKKVVDIYnyvHSIEEDRPYIIQTKDQYVFIHQTILEA
  |.|.   . ||.   .        .  | | |||||.|||| . .|..|.   |. . ..| |..     .  ||   ...  |||.  ...|| 
dhgmpdscdtalrllsavkk......dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsf...vllrkdrarsvrvfpqyvyalrcvlef
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1-44 7.4e-11 36.4 In-house 111-154 (350) alignment 
Range on Protein: 1-44
Range on HMM: 111-154/350.0
GPLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD
.|| |  |||.... . |  ||..|| ..| |  ||..||.  .
aPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2-187 7.4e-70 229.8 In-house 59-239 (239) alignment 
Range on Protein: 2-187
Range on HMM: 59-239/239.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPstDQPAAYGVLTVSLKKKEEFSDYTVRSFTTfYRWTLKGVRLIHQYQFTSWPHRGVPQQT
 .| |. |||.|.|||.  ||||||||||| . |||||||  |  . |  | |.|.| | |.|| .|.|    .      | ..||.|| || .|||| .
cveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvtlrktevfadyiirtfvm.sqvgqteeryvyqyhftvwpdkgvpqya

AALLRFRKNIIDRppHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.|.| .|..|      .| . ||.||||||.|||| ||||||||||||..| |||.|||..| ||||...|| .|||||| ..|||
tavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2-186 2.9e-69 227.8 In-house 60-239 (239) alignment 
Range on Protein: 2-186
Range on HMM: 60-239/239.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPstDQPAAYGVLTVSLKKKEEFSDYTVRSFTTfYRWTLKGVRLIHQYQFTSWPHRGVPQQT
 .| |. |||.|.|||.  ||||||||||| . |||||||  |  . |  | |.|.| | |.|| .|.|    .      | ..||.|| || .|||| .
cveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvtlrktevfadyiirtfvm.sqvgqteeryvyqyhftvwpdkgvpqya

AALLRFRKNIIDRppHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.|.| .|..|      .| . ||.||||||.|||| ||||||||||||..| |||.|||..| ||||...|| .|||||| ..||
tavlglrrkitkd..slpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2-188 2.4e-62 205.9 In-house 107-290 (298) alignment 
Range on Protein: 2-188
Range on HMM: 107-290/298.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTdQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRwTLKGVRLIHQYQFTSWPHRGVPQQT
||...  |||.||..|. ..||||| | | ...|.|.|||.. . . || .||||..||||.|..|| ..   . . .. | ..| .||||| .|||...
PltetvedFWrmvteedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskk.keekerevrqlhftsWpdkgvpena

AALLRFRKNIIDrPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
 ..| .....    ..     | |..||||.||.| | .||..| ..|...|||....|. . ..|| ..||..|||||.. .||||
tsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-188 2.5e-51 169.6 In-house 100-284 (297) alignment 
Range on Protein: 2-188
Range on HMM: 100-284/297.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNElKCHQYWPSTDQpAAYGVLTVSLKKKEEFSDYTVRSFTtFYRWTLKGVRLIHQYQFTSWPHRGVPQ--
| ... .|||.||..|. |.||||. . |... || .||. .   ...| ..| |.  .| . .  |...   .   |  |...||||..||.. |..  
PmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv.ttfGdvsvvllsvsereGfikrele.vtkgkakarrvvkqyqfveWPdkaverkd

QTAALLRFRKNIIDRPPHVPESgPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
....|| . ... .   .. |. | ..||.||.||||..| || .. .||..| |||...|. . ..|||..|||.|| |.....||||
sassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2-187 2.2e-46 153.5 In-house 99-287 (325) alignment 
Range on Protein: 2-187
Range on HMM: 99-287/325.0
PLESSCDDFWQMV--WQekCSVIVMLTGLiEGNELKCHQYWPST-DQPAAYGVLTVSLKKKEEFSDYTVRSFTTfyRWTLKG-VRLIHQYQFTSWPHRGV
|| .. .|.|..|  |.  |||.|.|  | .... .| .|||    .   .| | |.|.  ||.|||  | .    . . ||  | ..|.|. ||.  ||
PltatindlWrlvldWr..csvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv..kqvkkGetrsvkqfqlqswddmGv

PQQTAALLRFRKNIIDRPPHVP----ESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
... |.|. . . .      |      |.| ..|||||.||||.|. . ..| .  |.  |||...|. . .||| ...| |||..|.... ||
qkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2-187 6.2e-43 141.8 In-house 99-278 (439) alignment 
Range on Protein: 2-187
Range on HMM: 99-278/439.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNElkchqYWPSTDQpAAYGVLTVSLKKKEEFSDYTVRSFTTFY-RWTLKGVRLIHQYQFTSWPHRGVPQQ
| . ..||||..|...|.. ||||| |.|        |||| .. . || ..|   .. |. .|..| |  |  | | .  | . |.....||.. || |
pkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq

TAALLRFRKNIiDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.. .| | . | .      | || ..|||||.||||  . .|  | | | .. |||   |. . ..|  ..|.  |||||....|| 
ashvldflrai.nsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_CG7180_pd Subfamily CG7180 2-187 7.5e-41 134.7 In-house 93-289 (296) alignment 
Range on Protein: 2-187
Range on HMM: 93-289/296.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNElKCHQYWPSTDqPAAYGVLTVSLKKKEEFSDYTVRSFTTFYR---------WTLKGVRLIHQYQFTSW
| ... |.||..|..|..| .|.||   . .. ....||| .   . || . | . ....... . | |    .              .|.....|.| |
pkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteW

PH-RGVPQQTAALLRFRKNI---IDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.    ||  |.||. .|. .   ... .. || || ....| | .|.|..| ||| | ...... ||....|  . ..|| .......| .| ...|||
eledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2-186 1.5e-30 101.0 In-house 96-285 (305) alignment 
Range on Protein: 2-186
Range on HMM: 96-285/305.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAY---GV--LTVSLK--KKEEFSDYTVRSFT---TFYRWTLKGVRLIHQYQFTS
||| .| ||| | .|.|   | ||  |.|    ||..|..| |..      .   ..| ..  .. .| . .    |        . . .| . .| .  
plektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwid

WPHRGVPQQTAALLRFRKNIidRpphvPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVD-IYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
|| ||||    |.| . ..   |    |  || ..||||||||||  .... .| |  . ....     .  | |.|   ||| .||.|.|| ||.
wpdrgvpaadlailelleka..r....pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2-185 1.1e-29 98.3 In-house 80-256 (267) alignment 
Range on Protein: 2-185
Range on HMM: 80-256/267.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNelkCHQYWPST-DQPAAYGVLTVSLKKKEEFSDYTVRSFTtfYRWTLKGVRLIHQYQFTSWPhrgVPQQ
||. .  ||.... ..|..|||.||   ..|    ...||    |   |  |||    ..|  || . ..    ..  .  . .  | .  |    .  .
plkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakkyqdltvehslekeendyqiitle..lkfknesahnvtlyyykkwn...intn

TAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
    |.    |. .      . | ...||.|.||.| |||||..|..||.  |.||....  | . |. ...||..|..||... 
nkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2-182 3e-24 80.3 In-house 12-197 (198) alignment 
Range on Protein: 2-182
Range on HMM: 12-197/198.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP-AAYGVLTVSLKKKEEFSDYTVRSFTTFYRWT-LKGVRLIHQYQFTSWPHRGVPQ
||  .  |||||||.     |||.      .|     |||.|.   . || |.|. |     .|||. ..      |     | | .||||||  .  |.
plretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpn

qTAALLRFR--KNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKK--VVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
  | .. |      . .        | |.||| | | ||.|. .|  .|  .| |  |||...  . . . |  || . ..| ||.|
.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2-182 3.2e-24 80.2 In-house 13-198 (199) alignment 
Range on Protein: 2-182
Range on HMM: 13-198/199.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQP-AAYGVLTVSLKKKEEFSDYTVRSFTTFYRWT-LKGVRLIHQYQFTSWPHRGVPQ
||  .  |||||||.     |||.      .|     |||.|.   . || |.|. |     .|||. ..      |     | | .||||||  .  |.
plretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpn

qTAALLRFR--KNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKK--VVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
  | .. |      . .        | |.||| | | ||.|. .|  .|  .| |  |||...  . . . |  || . ..| ||.|
.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2-188 5.7e-21 69.8 In-house 90-271 (288) alignment 
Range on Protein: 2-188
Range on HMM: 90-271/288.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST-DQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQQ
||..  . .|.|. ..    ||||. |.|    |  .|.||   . | .| |    ||| .  | .|.  .     . .   .. .  .  |.. |||..
PlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen

TAALLRFRKNIidrpphVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
  . ||. . .           | ..|.|||.|||| . .|  .|.... .  . | . ...  |.|   |||. ||...|. .|| |
ylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2-185 1.6e-18 61.2 In-house 99-285 (302) alignment 
Range on Protein: 2-185
Range on HMM: 99-285/302.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD----QPAAYGVLTVSLKKK-EEFSDYTVRS-FT---TFYRWTLKGVRLIHQYQFTSW
|  |... .| .. | . ...| |....|..| || .|.        .   | | |||.|.. |||.|      .|   . .... |  . ..  .|..|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PHRGVPQQTAALLRFRKNIIDRPPHVpesgpwIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
|. | |... . |   |        |      ..|||||.|||| .. |   .   ..||| |. . |  . . |   .|...| ...   . 
pdhGapkeaytaldilkfcesykknv......lvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvt
subfamily_egg_pd Subfamily egg 2-185 3.7e-17 57.0 In-house 91-267 (307) alignment 
Range on Protein: 2-185
Range on HMM: 91-267/307.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNelKCHQYWPSTDQ-PAAY--GVLTVSLKKKEEFSDYTVRsfttFYRWTLKGVRliHQYQFTSwpHRGVP
||  . ||||.||.||..  |||||   | .  .|. ||| ... .. .  | | .   | .. .|   |      .  | |    .. .|    |    
plkntvddfwrmvfqeevqyivmltsrkese..rceyywpkaesdslvtvpGslrienlkvdskadplfr....vtklklvGgd..deerfle..hwqgd

QQTAALLRFRKNIIDRPPHVpeSGPWIIHCSAGIGRTGIFLVIDA----MLRQAKEKKVvdIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
 . .. . .  ... .  ..  | | ....  |. ... .. |.     .||    | .  . . |  .   |.. ...  .|.|... .|
vnnssdvysplrvlrklrnl..skpvvvqdilGvskaatlvaieiallsllrGpitksl..vlravvflrlrrrlsvesvllylfvyrlvl
subfamily_CG42327_pd Subfamily CG42327 2-105 1.7e-15 51.5 In-house 80-184 (319) alignment 
Range on Protein: 2-105
Range on HMM: 80-184/319.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPST---DQPAAYGVLTVSLKKKEEFSDYTVrSFTTFYRWTLKGVRLIHQYQFtSWPHRGVP
.||.|  |||..||. .  ||| || | |    .| .|.|.    |.  .|| . |.||..|    | . |   . |   .  | .  | .  |.. .||
sledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryai.stlllkrvdkeesrelthywy.kwleaevP

QQTAALL
 . |||.
aeeaali
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2-186 1.3e-09 32.1 In-house 91-277 (303) alignment 
Range on Protein: 2-186
Range on HMM: 91-277/303.0
PLESSCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQPAAYG--VLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYqfTSWPHRGVPQ
||  .. |||||. ..|  ....|    | ..|  .  .|  ..   .   .. |   |. |..|  |    .    . |    .|.|   .|||  .| 
plshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhy..kawphnsips

QTA-ALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVID-AMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
...  ...   ..     .  .| | .    .| ||.| | ... | |   .|.  .|. . .  . . | . .|   |. ...  . |
dgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2-80 2e-09 31.3 In-house 244-319 (440) alignment 
Range on Protein: 2-80
Range on HMM: 244-319/440.0
PLESSCDDFWQMVWQEKCSVIVMLTGLiegNELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKG
||.|.  |||..| . . | |.||  |   |.  |  |||   .  ..| .||  |  |..    ||..   |.  .. 
pldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevhe
0036282 (Phosphotyrosine protein) phosphatases II 3-182 2.8e-34 113.7 In-house 26-164 (174) alignment 
Range on Protein: 3-182
Range on HMM: 26-164/174.0
LEsscddFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPStdqpaaygvltvslkkkeefsdytvrsfttfyrW--TlkGVRLIHQYQFTSWPHRGVPQQ
|.     ||.|.........|||. ..| .  ||..|||.                                        .||..||... || .|||  
la.....fwemlkelgittvvmlleekelglykcinywpe.................................lred..lerlgiqylylpwpDhgvpdl

TAaLLRFRKNIIDRPPHvPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKeKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
.  ||.| | . .   . ...|| ..|||||.||||.. ... |||. .  ..||....|...   ||...|| .|| |...
si.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 4-184 9.1e-20 65.3 In-house 103-281 (302) alignment 
Range on Protein: 4-184
Range on HMM: 103-281/302.0
ESSCDDFWQMVWQEKCSVIVMLTGLIEGNElKCHQYWP-STDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQQTA
|.| ..||.||.|||.  .|.| |  | ..   ....|  ...   || . |  .| |. .. . |              |.  | .| |..  ||.. |
edsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya

ALLRFRKNIIDRppHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTI
.| .  ... ..  ... . . .|    |.|| |.||.  . . . ...| . | . |.|| ..|| .... .|||... ..
eliktaakvfak..kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 4-185 1.5e-14 48.8 In-house 77-256 (290) alignment 
Range on Protein: 4-185
Range on HMM: 77-256/290.0
ESSCDDFWQMVWQEKCSVIVMLTGLIEGNEL----KCHQYWPS-TDQPAAYGVLTVSLKKKEEFSDYTVRSFTTFYRwTLKGVRLIHqYQFTSWPHRGVP
.|   .|| |. |||   .|||    | ..      | .| |   ..   .. |||. |.||.  |  .|  .  .    .   . | ... .| .. |.
nStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd.deeeftvtH.sllkgWnklnvq

QQTAALLRFRKNIIDrpphvpESGPWIIHCSAGIGRTGIFLVIDAMLRQA-KEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
..|  ||   ...        .  | |.||  || |  ..  |.       . .. | . . .... . |   |... .. |.   |.
edtktllsliqkvka......sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 6-179 1.9e-18 61.5 In-house 40-212 (255) alignment 
Range on Protein: 6-179
Range on HMM: 40-212/255.0
SCDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS-TDQPAAYGVLTVSLKKkeEFSDYTVRSFTTFYRWT-LKGVRLIHQYQFTSWPHRGVPQQTAA
. | |.|.. | | .|.|||. . | .  ||..|.|   |.   .  ..|.  |    .|  .|  .     .  |  . .. |... |. .  |...  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LLRFRKniidrppHVPESGPWIIHCSAGIGRTGIFLVIDA----MLRQAKEKKVVDIyNYVHSIEE---DRPYIIQTKDQYVF
.|   |        | .| . ..|||.||||.  | ...     |.|. .. . |.. .|.  .||    |.  |.|  |  |
ilnilk.......vvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetvel.dylslleelrskrkraihtPlqlaf
subfamily_hpo-7_pd Subfamily hpo-7 7-169 7.9e-15 49.5 In-house 47-208 (263) alignment 
Range on Protein: 7-169
Range on HMM: 47-208/263.0
CDDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPS-TDQPAAYGVLTVSLKKKEEfsDYTVRSFTTFYRWT-LKGVRLIHQYQFTSWPHRGVPQQTAAL
 | |.|.. | | .|.|||.   | .  || .|.|   |.   .  ..|.  |  .  |  ...          | .. ...|... |...  |...   
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LrfrkNIIDrppHVPESGPWIIHCSAGIGRTGIFLVIDA----MLRQAKEKKVVDIyNYVHSIEED---RPY
|    ||..    . .| . ..|||.||||.  | |..     |.|. .. . |.. .|.  .||    |. 
l....nilk...varnskslvvhcstGiGrsaafsvaElvyqkmirsldttstvel.dylsLleelrssrkr
0051082 (Phosphotyrosine protein) phosphatases II 8-185 4.2e-30 99.7 In-house 23-150 (151) alignment 
Range on Protein: 8-185
Range on HMM: 23-150/151.0
DDFWQMVWQEKCSVIVMLTGLIEGNelKCHQYWPSTDqpaaygvltvslkkkeefsdytvrsfttfyrwtlkgvRLIHQYQFTSWPHRGVPQQTAALLRF
.||...........||.|... | .  .|..|.|...                                     . ........||  |.|. ..|.|.|
adflellkelgiktivnlrseeerg..ycpeylpelg.....................................ievlhipildwpdpglplsfdavlef

RKNIIDrpphvPESGPWIIHCSAGIGRTGIFLVIDAMLRQakekkvVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
 . ..|     ...|| ..|||||.||||.. ... ||..      |...  .. . . ||...|...|..|... .|
lellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfall
0044763 (Phosphotyrosine protein) phosphatases II 8-182 1.5e-25 85.3 In-house 38-165 (178) alignment 
Range on Protein: 8-182
Range on HMM: 38-165/178.0
DDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTDQpaaygvltvslkkkeefsdytvrsfttfyrwtlkgvrliHQYQFTSWPHRGVPQQTAALLRF
 |............||.||. .|.. |||..|||.                                           ||... .|  |||. .. .|.|
addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipipDhgvpdllehflef

RKNIIDRPPhvPESGPWIIHCSAGIGRTGIFLVIDAMLRQakekKVvDIYNYVHSIEEDRPyIIQTKDQYVFIHQ
 . | .  .  .. || ..|||||.||.| . ... |...    .. .... .. . | || |... .|. ....
vefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLye
subfamily_eak_pd Subfamily eak 8-108 5.3e-07 23.3 In-house 107-204 (332) alignment 
Range on Protein: 8-108
Range on HMM: 107-204/332.0
DDFWQMVWQEKCSVIVMLTGLIEGNELKCHQYWPSTD-QPAAYGVLTVSLKKKEEFSDYTVRSFTTfyRwTLKGVRLIHQYQFTSWPHRGVPQQTaALLR
  ||||| ..|   ||.|   .| .  |  .|.|    .   .|.| |  |.  . . . .| .    .        .. |..  |    .|.    .| 
fafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllel..s.kGnethrvlhykvfGwtettlpkye.dfla

FR
.|
lr
0048076 (Phosphotyrosine protein) phosphatases II 56-184 4.9e-20 67.1 In-house 19-139 (145) alignment 
Range on Protein: 56-184
Range on HMM: 19-139/145.0
LKKKEEFSDYTVRSFTTFYRWTLKGVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIIDrppHVPESGPWIIHCSAGIGRTGIFLVIDAMLRqakeKKvVD
 .. |.. |. ..   .. . .   .||. ||....|| .|||. .. ||.| . | .   ...| || ..|||||.|||| . ... ||.    .. |.
aldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefiee...alkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vs

IYNYVHSIEEDRPYIIQTKDQYVFIHQTI
... .. . . ||..... .|. |... .
leealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 65-182 1.1e-19 66.1 In-house 31-139 (144) alignment 
Range on Protein: 65-182
Range on HMM: 31-139/144.0
YTVRSFTTFyRWTLKGVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIIDRPPhvpESGPWIIHCSAGIGRTGIFLVIDAMLrqakEKKvVDIYNYVHSIE
.|| ..|.  ..     | ..||....|| .|||. .. ||.| . | .  .   |.|| ..|||||.|||| . ... |.    ... ..... .. . 
ttvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvr

EDRPYIIQTKDQYVFIHQ
. ||..... .|. |...
srrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 82-188 1.2e-24 81.4 In-house 89-194 (440) alignment 
Range on Protein: 82-188
Range on HMM: 89-194/440.0
RLIHQYQFTSWPHRGVPQQTAALLRFRKNIIDRPpHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIH
| ..||.. .|| .|||. .. .|.. ... .   .   .|| ..||||| ||||. ...|..||.||    .||.... |. ..|| ..|| .||.|.|
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesq.ekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QTILEAL
...||.|
eavlegl
PTPc_DSPc_SM00012 84-186 7.6e-30 98.6 In-house 2-105 (105) alignment 
Range on Protein: 84-186
Range on HMM: 2-105/105.0
IHQYQFTSWPHRGVPQQTAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEK-KVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
...|..|.||. |||... ..|.. ... .   .  .|.| ..|||||.||||.| ..| .|.| ... | |||...|... . ||  .||..||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TILE
 .||
alle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 84-185 6e-11 36.6 In-house 217-341 (350) alignment 
Range on Protein: 84-185
Range on HMM: 217-341/350.0
IHQYQFTSWPHR---GVPQQTAALLRFRKNIIDRPP---H--VPESGPWIIHCSAGIGRTGIFLVIDAMLRQA-------KEK-------KVVD-IYNYV
..| |.  |.       |..    |  ....||      |    .| | ..|||||.||||... .| .| .        ||        |. | |   |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

HSIEEDRPYIIQTKDQYVFIHQTIL
  . . |  ..|..||..||....|
nelrkqrismvqnldqfifiYeall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 86-156 2.9e-07 24.1 In-house 222-302 (349) alignment 
Range on Protein: 86-156
Range on HMM: 222-302/349.0
QYQFTSWPHRGV---PQQTAALLRFRKNIIDRPP-----HVPESGPWIIHCSAGIGRTGIFLVIDAMLR--QAKEKKVVDI
| |.  |.  ..   |.     |  ....||        .  .. . ..||||| ||||..  .| .|   .  ... . |
qlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnki
0038934 (Phosphotyrosine protein) phosphatases II 101-177 7e-06 21.3 In-house 95-166 (194) alignment 
Range on Protein: 101-177
Range on HMM: 95-166/194.0
TAALLRFRKNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKekKVVDIYNYvhsIEEDRPYIIQTKDQY
. ..|.   ...|.  .  ..|   .|| ||.||||....   . |.    .. . ...   ..| || .|.. |..
sleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm..saeeAial...frekRpgaipnqdyl
subfamily_CG42327_pd Subfamily CG42327 109-185 1.8e-17 58.0 In-house 235-312 (319) alignment 
Range on Protein: 109-185
Range on HMM: 235-312/319.0
KNIIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEK-KVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
 ||  |  .  . || ..||| |.||||. .  |  .|. .|  . ||| . |.|. .||   ..||.|| ||.... 
gnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_eak_pd Subfamily eak 111-186 3.6e-08 27.2 In-house 226-303 (332) alignment 
Range on Protein: 111-186
Range on HMM: 226-303/332.0
IIDRPPHVPESGPWIIHCSAGIGRTGIFLVIDAMLRQ--AKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.. .  | | |   || .. |  |.|.|.||| ..|   .| | .  . ...  . . | . . .. |. ||.. .|.
tlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivld
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 118-186 1.2e-14 48.9 In-house 225-293 (297) alignment 
Range on Protein: 118-186
Range on HMM: 225-293/297.0
VPESGPWIIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
 | . . ..|||||.||.|. .  |..| . . |.. |.   .. . | |. ..|| .|. .... .|.
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_PTPDC1_pd Subfamily PTPDC1 124-182 2e-06 22.4 In-house 117-170 (182) alignment 
Range on Protein: 124-182
Range on HMM: 117-170/182.0
WIIHCSAGIGRTGIflVIDAMLRQAKEkkvVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
  .|| || ||||.  .| ..|  ||.   ..  . .. . . ||  |||..|  ....
vavhChaGlGrtGv..liacylvyakr...ltaekaiklvrskrpksiqtreqvelvke
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 125-188 3.2e-16 53.5 In-house 2-65 (69) alignment 
Range on Protein: 125-188
Range on HMM: 2-65/69.0
IIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
..|||.| |||| |. |   . . | .|.|||.| |  .   || ..  . .|.||| .. |||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 125-188 8.5e-16 52.1 In-house 1-64 (69) alignment 
Range on Protein: 125-188
Range on HMM: 1-64/69.0
IIHCSAGIGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
..|||.| |||| |. |   . . | .|.|||.| |  .   || ..  ...|.|||... |||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal