Gene NvecPTP-sf4-3 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP060_AA protein Get Run
NvecP060_AA_4-254 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 3-266 1.6e-118 391.8 In-house 34-294 (564) alignment 
Range on Protein: 3-266
Range on HMM: 34-294/564.0
ARRSFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRG--AGSGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELK
 ...|| .||. ..|.||||| || |||||||.|.   . .|.|||||..|. .. ..|.|||.||||.....|||.|||....|.||||| | |... |
egqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvk

CHQYWPSTDqPAAYGVLTVSLKKKEEFSDYTVRSLLLsKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvSESGPWIIHCSAGVGRT
||.|||... .. || |||.|...||..||..|.. | |. . .|.| ..|..|||||..|||.....||...... . ..  ...||...|||||||||
chkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRT

GIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIKRPHLH
|.|.||||||...||.|.||||.||. . ..|....||..||.|||..||||| . |. ..  .|.
GtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 4-262 4.5e-91 300.2 In-house 33-289 (318) alignment 
Range on Protein: 4-262
Range on HMM: 33-289/318.0
RRSFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKC
....||. .  . |.||||| || ||||.|| |.      | ||||| ||  .    |.|||||.||   ..|||.|||. ...|||||| . ||   |.
eetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakv

HQYWPStDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIiNRSPHVSESGPWIIHCSAGVGRTG
|.|||| ... .|| |.| ||.. |.|||..|.. ...... .|.| ..||..|||| .|||...| || . ... ..  . |. || ..||||||||||
hryWPs.kgsrsygklvvelkeevelsdyvlrefkvtrtee.eesrqvrqyhytsWpdegvpesgaslldlvrqv.skaqqksgagpivvhCsaGvGrtG

IFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIKR
.|...|..|...|. ..||....|. . | |. ..||.|||.||....||||.. .. .. 
vfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevda
subfamily_PTPN6_pd Subfamily PTPN6 4-258 3.4e-81 267.6 In-house 41-301 (306) alignment 
Range on Protein: 4-258
Range on HMM: 41-301/306.0
RRSFTSHAAKLSHNRAKNRYGNIQAYDHSRVML-RGAGSGCDYINATYIK-DFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKC
.. .. . ..  .|. |||| ||  .||.||.| .   .| ||||| ||| .. |. |.|||.|| ||.  .|||.|||||.. ||||.|  .||.. ||
kkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekC

HQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVS--ESGPWIIHCSAGVGR
 .|||.. .  .||...|.  .... .||..|.|..||. . || | ..||.|.|||  |||... |.| | ... ... ...  |.|| ..|||||.||
arYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGR

TGIFLVIDAMLRQAKEKKV---VDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEaLIAENK
|| |.|||..|.. ..|..   .||.. |.|. | |  ..||..|| |....| .  | ..|
tGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk.yietkk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 4-53 8.1e-08 26.2 In-house 26-76 (244) alignment 
Range on Protein: 4-53
Range on HMM: 26-76/244.0
RRSFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGA-GSGCDYINATYIKD
 | |    | || | .|||| ||  .|..||.|  .   |.||||| ||. 
treflqtnavlsanatknryinilpfdetrvilssskkegsdyinanyiqg
0046845 (Phosphotyrosine protein) phosphatases II 5-254 7.8e-91 299.6 In-house 16-275 (284) alignment 
Range on Protein: 5-254
Range on HMM: 16-275/284.0
RSFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAGSG---CDYINATYIKDFD----GTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERN
.... ..|.| .|. |||| .| .|||||| |.  ...   .||||| |.. .|     ..|..||.||||.....|||.|||.....||||||.|.|..
lllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelveng

ELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGV
  ||.||||.....  || .|| |...|...||||| | |.. |. .|.| ......||||..|||.... ||.| . . .  .... .|| ..||||||
rekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

GRTGIFLVIDAMLRQAKEKK---VVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALI
|||| |...| .|.| ....   .||....|. . | ||. .|| .||.|.....||.| 
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 5-266 2.8e-84 277.9 In-house 36-296 (319) alignment 
Range on Protein: 5-266
Range on HMM: 36-296/319.0
RSFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINATYIKDFDGTpKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCH
 ..| . |.  .|. |||| || |||..||.|       | |||||..|  ..   . .||.|.|||   .|||.|||.|..|..||||.| |. ..|..
vndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklk

QYWPSTdQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIiNRSPHVSESGPWIIHCSAGVGRTGI
.|||.. ..  || |.| |...|| .|| .| | | |. .  | | . ..|.|.||  .||... .|| . |.| ..| . ..||| ..|||||||||| 
kywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkri.rksrektqsgPivvhCsaGvGRtGt

FLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIKRPHLH
|.|.|||| . ||  |.|....|  .   |. ..|...|| ||....|||. | .  |.  .|.
fivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlr
subfamily_PTPRG_pd Subfamily PTPRG 5-266 2.1e-82 272.2 In-house 35-300 (563) alignment 
Range on Protein: 5-266
Range on HMM: 35-300/563.0
RSFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAGS---GCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKC
.... ....  .|. |||| || |||.||| |..        ||||| ||. .    | .||.||||.. ..|||.|.|... ..|||.| | ||.  ||
kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkc

HQYWPStDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSK----QGT-LKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVSESGPWIIHCSAG
..|||. |..  ||.|.| |...| .. ||||.| . .    ..   ....|. ||..|.||  |||....  | | |       . .| || ..|||||
dvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaGPivvHcsaG

VGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIKRPHLH
|||||...|.|..|.| .....|.... .. |.  |....||..||.|.|...|||. .... ..  ...
vgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve
subfamily_PTPN12_pd Subfamily PTPN12 5-258 2.1e-70 231.9 In-house 28-282 (290) alignment 
Range on Protein: 5-258
Range on HMM: 28-282/290.0
RSFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAG--SGCDYINATYIKDFDGtPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCH
. ....|.. ..|..|||| .|  ||.|||.|.      | ||||| .||  .| ...||||||||    .|||.|.|. . ...||.  ..| .  ||.
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

QYWPSTD-QPAAYGVLTVSLKKKEEFS-DYTVRSLLLSKQgtlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvSESGPWIIHCSAGVGRT
.|||..  ..  .| ..|.|.... .. |...|.| . .|   || | ..|...|.|| .|||...  ||.. ... ..    ||. | ..|||||||||
rYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrt

GIFLVIDAMLRQAKEKKV---VDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENK
|. ..|| . .. |..|.   .|... | .. ..|. ..|||.||........| . .| .
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5-253 9.1e-68 223.2 In-house 34-283 (290) alignment 
Range on Protein: 5-253
Range on HMM: 34-283/290.0
RSFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAGSGCD----YINATYIKDFDGTpKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELK
...| . .  | |. .||. ||  ||  |..||  ..  |    ||||.|||..    | |||.|||...   |||...||||...|||||  || .. |
sehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvk

CHQYWPSTDQPAaYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRG-VPQQTAALLRFRKNIinRSPHVSESGPWIIHCSAGVGR
|.||||..|. | ||  .. | . |....|. | | . .. . .. . ..|||.|.|.. | |..... || ... .  .  . .  .. ..|||..|||
CqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemy..ktqrkrgntsivvHCSdtvgr

TGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
...|....  . ..| . |.|... ..|    .|  .||..|| .|.| .|..|
savfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
0050432 (Phosphotyrosine protein) phosphatases II 6-254 8.5e-91 299.8 In-house 57-300 (308) alignment 
Range on Protein: 6-254
Range on HMM: 57-300/308.0
SFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLrgaGSGCDYINATYIKDFD-GTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQY
...  .|.|  |. |||| .| .|||||| |   ..|.||||| |.. .. . |...||.||||.....|||.|||.....|||||| |.|..  ||.||
lleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqY

WPST--DQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphvsESGPWIIHCSAGVGRTGI
||..  ...  || .|| |.. |...||||| | |.. |.  |.| ......|.||. |||.....||.| . . ..     ..|| ..|||||||||| 
wplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl....pggpivVHCsaGvGRtGt

FLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALI
|...| .|.| .... ||....|. . | ||. .||..||.|.....|| | 
fialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 6-260 3.4e-89 294.0 In-house 45-297 (298) alignment 
Range on Protein: 6-260
Range on HMM: 45-297/298.0
SFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRG--AGSGCDYINATYIKDFDGTPkTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQ
......|. ..|. |||| .| |.|.|||.|.   |   .|||||.... ..|.. ..||.|.||... .|||.||..|. ..||||| | | ...|.|.
eeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhk

YWPSTdQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINrSPHVSESGPWIIHCSAGVGRTGIF
|||.. . . || .||||..||||.|..|| | .||. .  . | ..| .||||| .|||... ..| .....   |.. .   | |..|||||||.| |
ywPde.gketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtf

LVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRI
 .||..| ..|...|||....|. . ..|| ..||..|||||.. .|||| . |  |
iaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0051299 (Phosphotyrosine protein) phosphatases II 6-253 5.3e-89 293.8 In-house 38-286 (288) alignment 
Range on Protein: 6-253
Range on HMM: 38-286/288.0
SFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAGS--GCDYINATYIkDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQ
..| .||.| .|. |||| .| .|||||| |.  ..  |.||||| || |.  .....||.||||.....|||.|||.....||||||.|.|..  ||.|
dltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaq

YWPStDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQG---TLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvSESGPWIIHCSAGVGRT
|||. ...  || .|| |.. |...||||| | ... .     .|.| ......|.||. |||. . .||.| . ...  .  | .|| ..|||||||||
Ywpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRt

GIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
| |...| .|.| .....||....|. . | ||...|| .||.|.....||.|
gtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 6-253 3e-85 281.4 In-house 28-277 (297) alignment 
Range on Protein: 6-253
Range on HMM: 28-277/297.0
SFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLrgAGSGCDYINATYIkDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
...  .|.|  |. |||| .| .|||.|| |   ..|.||||| |. |. . ....||.||||.....|||.|||.....|||||| |.|..  ||.|||
lgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqyw

PST-DQPAAYGVLTVSLKKKEE--FSDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGI
|.. ...  || .|| |.. |.  ..|||.| | ... |.  |.| ......|.||. |||. .| ||.| . . .. ..  ..|| ..||||||||.| 
pleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgt

FLVIDAMLRQAK---EKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
|...| ||.| .   . . |||...|... | || ..|| .||.|.....|| |
fiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 6-253 4e-84 277.6 In-house 27-272 (273) alignment 
Range on Protein: 6-253
Range on HMM: 27-272/273.0
SFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLrgAGSGCDYINATYIkDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
..|  .|.| .|. |||| .| .|||||| |   ..|.||||| |. |.  .....||.||||.....|||.|||.....|||||| |.|..  ||.|||
lltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYw

PSTDQ--PAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKeVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGIF
|.. .  .  || .|| |.. |...||||| | |.. || . .| ......|.||  |||.... ||.| . . .   .. ..|| ..|||||||||| |
pleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtf

LVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
...| .|.| .... ||....|. . . ||...|| .||.|.....|| |
ialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN3_pd Subfamily PTPN3 6-252 8.3e-74 243.0 In-house 30-274 (280) alignment 
Range on Protein: 6-252
Range on HMM: 30-274/280.0
SFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAGSgcDYINATYIK-DFDGTP--KTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCH
. . .||....| .|||| .| .||. ||.|. . .  ||||| |.. . ..|   . |||.||||.....|||||||..|.|.||||| |.||   |||
glaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVSESGPWIIHCSAGVGRTGI
||||.|..   || ..| ..|..| . | .| |.|... | || | |.| |...||  |||...| .|.| ...  |. . ... | ..|||||.||||.
qyWPetedeleygefsvkcekedetksyvlrelvlkdket.keerkilqlqylaWpdhgvPddsadflefverv..rklrsgkeePvvvhCsaGigrtGv

FLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.....  |    ... | . . |. . . |  ..||..|| |. ..||..
lilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN1_pd Subfamily PTPN1 6-254 5.6e-66 217.2 In-house 21-274 (290) alignment 
Range on Protein: 6-254
Range on HMM: 21-274/290.0
SFTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAGSgcDYINATYIkDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
 |. ..||| .||..||| ... |||||..|. |    |||||. . ...   . || .|||| . .. ||||||..|.  .|||  ..|....||.|||
dfptreaklpenrnlnryrdvspydhsrikleradn..dyinaslv.eleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PSTDQ--PAAYG--VLTVSLKKKEEFSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTG
|. ..     .    |.| | ..|. | |||| | | .. | .| | | .. .|.||  |||.  ||.|.|  .. .    .|. || .||||||.||.|
Pqgeeekellledtklkvkliseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

IFLVIDAMLRQAKEKKV---VDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA--LI
 | ..|..| . ..|.    ||| . .  . . |  .|||.||  | ...|||   .|
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
0049772 (Phosphotyrosine protein) phosphatases II 6-252 3.2e-38 127.6 In-house 35-279 (314) alignment 
Range on Protein: 6-252
Range on HMM: 35-279/314.0
SFTSHAAKLSHNRAKNRYGNIQAYDhSRVML-RGAGSGCDYINATYIKDFdgtpKTYIAAQGPLESSCNDF----------WQMV--WQEKCSVIVM---
..|  .|.|  || |||| .|. .| .||.| .  .||.||||| |.. |    ...||.|||||  ..||          |.||  .. .. .|||   
eltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LTGLIERNelkchqywpstDQPAAYGVLTVSlkkkeefS------DYtvrslllskqgtlkeVRLIHQYQFTSWPHRGVPqQ
                  |..| ...           ..| |  . .         .      ..                ||. .|  . .|  ..|  
evladelsrLdaAlgKtpllildgng...........neptaadlellk.......eelydpelf...............erlgikylripvpDgsap.l

TAALLRFRKNIINRsphvSESGPWIIHCSAGVGRTGIFLVIDAMLRQAKEkKVVDIYNYVHSIeedRP-----YIIQTKDQYVFIHQTILEA
.. ...| . | .     .. || ..||.||.|||| |.|.. .... .   . .....|...   ||       |.. .||.||.. .||.
ledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlk...Rpinpnpgfieqleqyefilealley
0045450 (Phosphotyrosine protein) phosphatases II 7-252 1.1e-82 273.5 In-house 45-303 (307) alignment 
Range on Protein: 7-252
Range on HMM: 45-303/307.0
FTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAG---SGCDYINATYIKDFDG-------TPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIER
..  .|.| .|. |||| .| .|||.|| |   .   ...|||||.|......        ....||.||||.....|||.|.|.....||||||.|.|.
geysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvel

NELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAG
.  ||.||||.....  || .|| |...|. ..|||| | ..  .  .|.| ......|.||. |||. .. ||.| . . .   . ...|| ..|||||
grekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaG

VGRTGIFLVIDAMLRQAKEKKV---VDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
||||| |.... |||| .. ..   ||... |. . | || ..|. .||.|... .|| 
vgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 7-255 1.1e-80 265.8 In-house 31-278 (281) alignment 
Range on Protein: 7-255
Range on HMM: 31-278/281.0
FTSHAAKLSHNRAKNRYGNIQAYDHSRVML--RGAGSGCDYINATYIKDFDGtPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQY
 |..|.|  .|. |||| || |||..|| .    . . .||||| ... ..| .| |||.|||. .|...||||||..| |.|||.|  || . ||||.|
ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrY

WPSTDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGtlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHvSESGPWIIHCSAGVGRTGIFL
||  ..   || .||. ...|| . |  | . |....   | | ..| ..|.||  |||..|..|| |||.. . . . ..  | .||||||||||| ..
WPddnselkygdvtvkstaeeekatyierkfkleres..getreveqlaytaWPdhGvPattkellefrkevlkltek.ktkaplvihCsaGvGrtGtyi

VIDAMLRQAKE-KKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIA
 .| ....... .. .|. . |... ..| ...||  || |.....|.||  
alDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Ptp69D_pd Subfamily Ptp69D 7-254 3.4e-69 228.3 In-house 38-287 (307) alignment 
Range on Protein: 7-254
Range on HMM: 38-287/307.0
FTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINATYIKDFDGTpKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQY
 ......   |  |||| .|.|.|. ||.|.        ||||| .|| .. . |..||||.|.|.  .|||.|... .  .||||. | | |. ||..|
kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakY

WPSTdQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQG----TLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRsPHVSeSGPWIIHCSAGVGRT
||   .   || . | | ..|. |||. |.| .||..     ... | . ||..|.|.   ||... .||.. ... .  .. .  .| ..||||||||.
Wpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel.ykln.rsPivvhCsaGvgrs

GIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALI
|||. .| .| | |. . |||.. |. . ..|. ..|  .||||... .|.   
gifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPN13_pd Subfamily PTPN13 7-253 5e-66 217.8 In-house 27-269 (273) alignment 
Range on Protein: 7-253
Range on HMM: 27-269/273.0
FTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAGSgcdYINATYIKDFD-GTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
 |.. .|  .|..|||| |.  ||..|| | . |.   ||||..||        .|||.||||  ...|||||||. |..||.|.|   |....|||.||
dtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchryw

PSTDQ-P-AAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVsESGPWIIHCSAGVGRTGIF
|.. . .  ... |.|.| | .. ....||.| .... . .|.| . . .|..||  |||...| ||.| ...  |. .  ..|| ..|||||.||.|..
Pesknkklkvsnrlevellkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaev..rrlqt.dagPivvhcsaGiGrsGtl

LVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
..||..|   . .| .|. . |... | |  ..||||||.|....|||.|
itidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 7-250 1.1e-55 183.5 In-house 28-274 (287) alignment 
Range on Protein: 7-250
Range on HMM: 28-274/287.0
FTSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAG-SGCDYINATYIKDFDGtPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
.| .||.   .  ||||...  .|..||.|   |  | ||||| |.  .    ...||||||. .. .|||..|.... ......|  .|   |||..||
atfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytd.deafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykyw

PSTDQPAAYGVLTVSL-KKKEEFSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNI---INRSPHVSESGPWIIHCSAGVGRTG
|  ..|   |  .| | ...    .|.||.| | .  | .| |...|... ||| ....  . .|.||  ..   |. .   || || ..|...|.||.|
PerevPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsG

IFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
|.| . ..... ..   ||. . |  . | |  ..|.  |. .. ... 
illatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPRB_pd Subfamily PTPRB 8-256 1.9e-91 301.1 In-house 42-288 (293) alignment 
Range on Protein: 8-256
Range on HMM: 42-288/293.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVML--RGAGSGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
. .||.|. ||||||| || .|||||| |      || ||||| ||...  .|. .||.|||| .. .|||.|||..|.|.||||| |.|.   ||..||
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYW

PSTDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKqgtLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGIFLV
|....| .|| ..|.|...|| .|...|.|...|    || | ..||.|||||  |||..|..||.| ... ..  . ....| ..||||||||||.|. 
PadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfia

IDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAE
.| .|.. .|. .|||.  |... |.| ...||..||.||||..|. |  .
ldrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 8-252 3.8e-84 277.2 In-house 38-278 (288) alignment 
Range on Protein: 8-252
Range on HMM: 38-278/288.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVMLRG--AGSGCDYINATYIKDfDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
...|..|..|  |||| || .||. || |..   ..| |||||.||.. ..  |.|||.|||| .. ||||..|...| | |||||.|.|... ||..||
svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidg.ekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYW

PSTDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTlkeVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRspHVSESGPWIIHCSAGVGRTGIFLV
|..|.|  || .|| |....|  |...|.||| |..|    . |.|||...||  |||...| || ..... .   . ...|| |.||||||||||.|..
PdadkpknyGsvtvtlveskeledfvlrklllekkkt...eleitqyqylaWpdhgvPeskapllellrqvkva..nqadtgpiivhCsaGvGrtgtFia

IDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
.||.. . .|....|. . |. . . |. ..||. ||.||....|. 
ldalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
DSPc_SM00195 8-252 7.2e-79 260.2 In-house 17-261 (263) alignment 
Range on Protein: 8-252
Range on HMM: 17-261/263.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAG--SGCDYINATYIKdFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
... |. ..|..|||| ||  |||.|| |      .| ||||| ||| ..  .|.|||.||||.| ..|||.|||.||...|||||   |... ||..||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyik.gankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PST-DQPAAYGVLTVSLKKKEEFS-DYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVseSGPWIIHCSAGVGRTGIF
|.. ...  .| ..| |...|. . ....| | |.|.|. .| | ..|||...||..|||..|  .|.. . . ... .   ||| ..||||||||||.|
peesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtf

LVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
..|| .|.. .|.| ||| . | .. . || ..||..|| ||...|||.
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 8-252 7.2e-79 260.2 In-house 17-261 (263) alignment 
Range on Protein: 8-252
Range on HMM: 17-261/263.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAG--SGCDYINATYIKdFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
... |. ..|..|||| ||  |||.|| |      .| ||||| ||| ..  .|.|||.||||.| ..|||.|||.||...|||||   |... ||..||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyik.gankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PST-DQPAAYGVLTVSLKKKEEFS-DYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVseSGPWIIHCSAGVGRTGIF
|.. ...  .| ..| |...|. . ....| | |.|.|. .| | ..|||...||..|||..|  .|.. . . ... .   ||| ..||||||||||.|
peesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivVhCsaGvgRtgtf

LVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
..|| .|.. .|.| ||| . | .. . || ..||..|| ||...|||.
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPRA_pd Subfamily PTPRA 8-255 4.4e-78 257.5 In-house 49-297 (330) alignment 
Range on Protein: 8-255
Range on HMM: 49-297/330.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGA-G-SGCDYINATYIKDFDGTpKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
|  .|.   |. |||. ||  ||.|||.|    |    |||||..|. .    ...||||||.| . .|||.|.|. | . ||||| | ||.| ||.|||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PStDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGT---LKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSEsgPWIIHCSAGVGRTGI
|. .   .|| ..|.......  ||||| .|. ...     |..||..|. |||||. ||| ..  .|.. |.. .  .  ..  | ..|||||||||| 
Pd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtGt

FLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIA
|.|.||.| . | ...||... |...   || ..||. ||.||....||  . 
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_PTPN9_pd Subfamily PTPN9 8-252 5e-68 224.3 In-house 33-289 (297) alignment 
Range on Protein: 8-252
Range on HMM: 33-289/297.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
| .|.||  |  |||| ..  ||..||.|      .  ||||| ..  .   .|..||.||||.  ..|||.|||.... |||| | ..||  ||| |||
tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyW

P-STDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVS-----------ESGPWIIHC
| .... | .| |.||  . || .||.||.| ...  | .| | .  .||.|||  |||...|.|| ..... ..   ..           .  | ..||
pleeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhc

SAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
|||.|||| |  .|  | . .|. .||. . |. . . | . ||| .||.| ....|| 
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_PTPRN_pd Subfamily PTPRN 8-251 8.4e-59 193.7 In-house 47-290 (297) alignment 
Range on Protein: 8-251
Range on HMM: 47-290/297.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
|...||  .|  |||. .. .|||||| |.     .  |||||. | | |    .|||.|||| |.  |||||||.. . |||.|| | | .  .|..||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PSTDQpAAYGVLTVSLKKKEEFS-DYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNiINRSpHVSESGPWIIHCSAGVGRTGIFL
| . . . |..  | |  .  .. || |||. |    | .| | . |. | |||..||| .. .|| ||.  .|.| .   | | ..|||.|.||||...
pdeGs.evyhiyevhlvsehiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrk.vnks.yrGrscpivvhcsdGaGrtGvyi

VIDAMLR-QAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.|| .|   .|  | .||   .  . ..|| ...||||. |. ... |
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN14_pd Subfamily PTPN14 8-253 1.3e-54 180.3 In-house 40-296 (300) alignment 
Range on Protein: 8-253
Range on HMM: 40-296/300.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAG-SGCDYINATYIKDFD-GTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
. ..|||  |  |||. ..  |...|| |  .  .  .||||. ||    |. ..||.||||||  ..|||||||... ..|||||  .|    |...|.
llstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

PST---DQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVS-------ESGPWIIHCSA
|..    . . .|   |. | .|. . .. ..| |    . || | ..  |.| || .|||.     | . ...     ...       .. | ..||||
Pkleskkktvefgkfkvttkfsedsdsvittglklkhlps.keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsa

GVGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
||||||. .. | ..   .  ...|| . .. . | | ...||  || |....... |
GvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_ptpA1_pd Subfamily ptpA1 8-212 2.8e-38 126.7 In-house 39-255 (418) alignment 
Range on Protein: 8-212
Range on HMM: 39-255/418.0
TSHAAKlSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINATYIKDfdGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYW
||   |  || .|||| ||   .|.|| |.      | ||||| ||      || .|..||||  .  |||.|||...| .||||.   |   .|| .||
tsegdk.khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

PS---TDQPAAYGV-----LTVSLKKKEEFSDYTVRSLLLSKQGTL-KEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVS----ESGPWIIH
|     .| . ||       | |..  |   |     .    . |.  | | | |||.  || . .|..|  . .. ..| ||  ..        | |.|
peqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivh

CSAGVGRTGIFLVIDAMLRQ
||||||||| |     |...
csagvgrtgtfctavimmkk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 8-54 2.4e-09 31.0 In-house 38-86 (440) alignment 
Range on Protein: 8-54
Range on HMM: 38-86/440.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAG--SGCDYINATYIKDF
 |. | |  |. |||| || |||||||||         |||||.||.  
psdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 8-99 1.5e-07 24.5 In-house 18-83 (169) alignment 
Range on Protein: 8-99
Range on HMM: 18-83/169.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINAtyikdfdgtpktyiaaqgplesscndfwQMVWQEKCSVIVMLTGLIERNEL
    |.|. | .|||     |  | || |.      |.|||||                            .|.|.   ||||.| .  ..|..
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddknnf
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 8-99 1.8e-07 24.1 In-house 17-82 (169) alignment 
Range on Protein: 8-99
Range on HMM: 17-82/169.0
TSHAAKLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINAtyikdfdgtpktyiaaqgplesscndfwQMVWQEKCSVIVMLTGLIERNEL
    |.|. | .|||     |  | || |.      |.|||||                            .|.|.   ||||.| .  ..|..
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddknnf
0043336 (Phosphotyrosine protein) phosphatases II 9-251 4.2e-79 261.2 In-house 37-275 (278) alignment 
Range on Protein: 9-251
Range on HMM: 37-275/278.0
SHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAGSG--CDYINATYIkDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWP
   |.| .|. |||| .| .|||||| |   |.   .||||| |. |.   |...||.||||.....|||.|||......|||||.| |..  ||.||||
ysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp

stDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEvRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvSESGPWIIHCSAGVGRTGIFLVI
  ...  || .|| |.| |...||||| | ... |. .. | ...|....||. ||| ... ||.| | .... .  ...|| ..|||||||||| |...
..ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfial

DAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
. .|.|..  . ||... |. . | || ..|| .||.|... .||
yllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 9-261 1.7e-67 222.9 In-house 40-296 (325) alignment 
Range on Protein: 9-261
Range on HMM: 40-296/325.0
SHAAKLSHNRAKNRYGNIQAYDHSRVMLRGAG--SGCDYINATYIKDFDGTpKTYIAAQGPLESSCNDFWQMV--WQekCSVIVMLTGLiERNELKCHQY
 ..| . .|.||||. |. |.|.|||.|   .  . .|||||.|..|. .  ....||| || .. ||.|..|  |.  |||.|.|  | . .. .| .|
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr..csvvvvlnel.dlgkdrcavy

WPST-DQPAAYGVLTVSLKKKEEFSDYTVRSLLLsKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSE----SGPWIIHCSAGVGR
||    .   .| | |.|.  ||.|||  | | . ||    | | ..|.|. ||.  ||... |.|. . . . . |  |      |.| ..||||||||
wpkemgksktfGglevklrtieeisdyvhrvldv.kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGr

TGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIK
||.|. . ..| .  |.  |||...|. . .||| ...| |||..|.... ||... |  . 
tGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 9-263 1.9e-60 199.3 In-house 37-246 (392) alignment 
Range on Protein: 9-263
Range on HMM: 37-246/392.0
SHAAKLSHNRAKNRYGNIQAYDHSRVML--RGAGSGCDYINATYIKDFDGtPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNelkchqywp
  .|.   |  ||||.||  || .||.|      .  ||.||.||. ||   |.|||.|||  .| .|||.||.||. . |.|.| | | .         
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdn.ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

stdqpaaygvltvslkkkeefsdytvrslllskqgTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVSESGPWIIHCSAGVGRTGIFLVI
                                     ...| . |..|| || ..||..|..||.| |..  .. . . . | ||||||||||||. . |
...................................kgddartvaqfhftewPdkdvpkhtssllkfikev..kadfGqythpliihcsagvgrtgvvisi

DAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIKRP
|... .||. ..||..|.|  | . |||..|||.|| ||. ..|| |.  |  |   
dsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvv
0040438 (Phosphotyrosine protein) phosphatases II 10-253 2.5e-82 272.0 In-house 36-276 (317) alignment 
Range on Protein: 10-253
Range on HMM: 36-276/317.0
HAAKLSHNRAKNRYGNIQAYDHSRVMLRGAGS--GCDYINATYIkDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPS
  |.|  |. |||| .|  |||||| |   |.  ..||||| |. |.   ....||.||||.....|||.|||.....|||||| | |..  ||.||||.
svaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl

tDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvSESGPWIIHCSAGVGRTGIFLVID
 ...  || .|| |.. || ...|.| | ... |.  |.| ......|.||. |||. .  ||.| . . .  .  ...|| ..|||||||||| |....
.getltygdftvtllseeelagitlrtlevedlgds.esrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgRtGtfiaay

AMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
 ||.| .... ||... |. . | ||...|| .||.|... .|| |
lmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 10-264 1.8e-74 245.4 In-house 37-288 (315) alignment 
Range on Protein: 10-264
Range on HMM: 37-288/315.0
HAAKLSHNRAKNRYGNIQAYDHSRVML--RGAGSGCDYINATYIKDFDGtPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPS
..|. . |  ||||.||  .|..||.|         |||||.||| .|   |.|||.||||..| .|||.||.||| . |||.| . | . .|| |||| 
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd

-TDQPAAYGVLTVSLKKKEEFSDYTVRSLlLSKQGtlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRspHVSESGPWIIHCSAGVGRTGIFLVI
   . . .| . |.| . |  .| ..| |   ...  .| | . |.||| ||..||..||..||.. |..     . ..  . ..||||||||||... |
rkadsvefGsikvellsleadtdgvarkl.vtrks..eesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisi

DAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIKRPH
| .. |.|....||..|.|. . ..|||..||...| ||....|| |   |  |.  |
devvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvih
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 10-255 1.2e-71 236.7 In-house 54-293 (319) alignment 
Range on Protein: 10-255
Range on HMM: 54-293/319.0
HAAKLSHNRAKNRYGNIQAYDHSRVMLRGA-G-SGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTgliernELKCHQYWPS
  | | .|. |||..|| |.|...| |.   |  . |||||.... .   .. ||||||||. . .|||.|.|. .|| ||.||      . || |||| 
tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywpl

TdQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGIFLVID
      ..   |...  || ..|.||.. ||..|  |..| |.|. |  ||. |||.... |.|. |..     .  .  . ..||||||||||...|.|
k.ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld

AMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIA
..| . ||.| ||.||.|. . ..|. ..|   || ||. ..||  . 
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 10-256 6.5e-71 234.1 In-house 18-258 (284) alignment 
Range on Protein: 10-256
Range on HMM: 18-258/284.0
HAAKLSHNRAKNRYGNIQAYDHSRVMLRGA-G-SGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTgliernELKCHQYWPS
  | | .|. |||.|.| |.|...| |.   |  . |||||..|. .   .. |||.||||. . .|||.|.|. .|| ||.||      . || |||| 
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

TdQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGIFLVID
      ..   |...  || ..|.||.. ||..|  |..| |.|. |  ||. |||.... |.|. |..   . .  .  . ..||||||||||...|.|
k.ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

AMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAE
..| . ||.| ||.||.|. . ..|. ..|   || ||. ..||  .  
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 10-251 2.3e-69 228.5 In-house 21-266 (274) alignment 
Range on Protein: 10-251
Range on HMM: 21-266/274.0
HAAKLSHNRAKNRYGNIQAYDHSRVMLRGAGS---GCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWP
.  ... .  |||| .|   ..|||.|. . |     .|||| ||| .|.. |.|.|.|||| .  .|||.|..||...|||||| | |.|| ||..|.|
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

STDQP---AAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEvrlIHQYQFTSWPHRGVPQQTAALLRFRKNIINR-SPHVSESGPWIIHCSAGVGRTGI
 . .      || . .  .|. |  ||.||.|.|...   ..   .. | .|.|| . .|... .||.. ... .  . .  . .| ..|||||.||||.
daedyeiserygdveikvekiverndysvrklvlkylerers...vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGc

FLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
|. |.  .|| .|..|||. . |  .  ||  ..||..|| .||... .
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 11-252 6.2e-94 308.6 In-house 1-239 (239) alignment 
Range on Protein: 11-252
Range on HMM: 1-239/239.0
AAKLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPst
|||   |.||||| || .||||||.|         |||||.|..|.||.||.|||.|| .| |. |||.|.|||.  ||||||||||  . |||||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..

DQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphVSESGPWIIHCSAGVGRTGIFLVIDA
|  . |  | |.|.| | |.|| .|....|. |   | | ..||.|| || .|||| ..|.| .|..| . |  .  . ||.||||||||||| ||||||
dstskycnlrvtlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkds..lpgarpwvihcsagvgrtgaflvida

MLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
||||||..| |||.|||..| ||||...|| .|||||| ..|||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 11-251 1.5e-93 307.3 In-house 2-239 (239) alignment 
Range on Protein: 11-251
Range on HMM: 2-239/239.0
AAKLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPst
|||   |.||||| || .||||||.|         |||||.|..|.||.||.|||.|| .| |. |||.|.|||.  ||||||||||  . |||||||  
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..

DQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphVSESGPWIIHCSAGVGRTGIFLVIDA
|  . |  | |.|.| | |.|| .|....|. |   | | ..||.|| || .|||| ..|.| .|..| . |  .  . ||.||||||||||| ||||||
dstskycnlrvtlrktevfadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkds..lpgarpwvihcsagvgrtgaflvida

MLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
||||||..| |||.|||..| ||||...|| .|||||| ..||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPRK_pd Subfamily PTPRK 11-260 5.6e-76 250.3 In-house 37-284 (314) alignment 
Range on Protein: 11-260
Range on HMM: 37-284/314.0
AAKLSHNRAKNRYGNIQAYDHSRVMLRGAGSG--CDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPST
|||  .||.|||.|.| |||.|||.|         |||||..|  .   |. .|..||||..  .|||..|..|.|. ||||| |.|   .|| .|||  
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

DQPaaYGVLTVSLKKKEEFSDYTVRSLLLSK-QGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHvsESGPWIIHCSAGVGRTGIFLVID
 .   || . | | . |  ... || . ..| . . .|.|...|.||..||. .||..  .||.. ... . ...  | |. ..||||| ||||.|..||
tev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaid

AMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRI
 .|  .....|||..| |... . .. ...|..||.||.. |||| .. .  |
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetai
0040439 (Phosphotyrosine protein) phosphatases II 11-252 1.8e-75 249.0 In-house 5-245 (249) alignment 
Range on Protein: 11-252
Range on HMM: 5-245/249.0
AAKLSHNRAKNRYGNIQAYDHSRVMLRGAGS--GCDYINATYIkDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSt
 |.|  |. |||| .| .|||||| |   ..  ..||||| || |.   ....||.||||.....|||.|.|.....|||||| | |..  ||.||||. 
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

DQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQgTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGIFLVIDA
...  || .|| |.. |...||||| | |..    .|.| ....|.|.||. |||. .. ||.| . . .   . ...|| ..||||||||||.|.... 
ggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
||.| .... ||....|. . . ||...|. .||.|... .|| 
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 11-264 4.9e-73 240.9 In-house 45-295 (297) alignment 
Range on Protein: 11-264
Range on HMM: 45-295/297.0
AAKLSHNRAKNRYGNIQAYDHSRVMLRGAGSG--CDYINATYIKDFDGtpkTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNElKCHQYWPST
 |.   |  |.|| ||  || |||.|.  ..    ||.|| ..| .      .|. | | ... .|||.||..|. |.||||. . ||.. || .||. .
vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk

DQpAAYGVLTVSLKKKEEFSDYTVRSLLLSKqGTLKEVRLIHQYQFTSWPHRGVPQ--QTAALLRFRKNIINRSPHVSESgPWIIHCSAGVGRTGIFLVI
   ...| ..| |.  .| . .  |.| ..| |  |  |...||||..||.. |..  ....|| . ... .   ...|. | ..||.|||||||..| |
gv.ttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvllti

DAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIKRPH
| .. .||..| |||...|. . ..|||..|||.|| |.....||||..|. ||.  .
dsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 11-260 1.6e-71 235.8 In-house 43-286 (315) alignment 
Range on Protein: 11-260
Range on HMM: 43-286/315.0
AAKLSHNRAKNRYGNIQAYDHSRVML--RGAGSGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPst
 || ..|. |||| || |||.||| |      ...||.||..|. ..  .. |||||||. .| .|||..|..|... |||||.|.|... |. .|||  
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp..

DQPAAYGVLTVSLKKKEEFSDYTVRSLllsKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRspHVSESGPWIIHCSAGVGRTGIFLVIDA
|.   || .||..|..| ...||||.|        ...| . |...||||  |||. | .|. . ...     | .. |. ..|||||||||| |. .||
dkkviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqh..htnsvgaivvhcsaGvGrtGtfitlda

MLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRI
.| ||. ....|.||... . . |  ..|. .|| ||....||.... .  |
vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi
0037934 (Phosphotyrosine protein) phosphatases II 11-251 6e-70 230.8 In-house 4-240 (243) alignment 
Range on Protein: 11-251
Range on HMM: 4-240/243.0
AAKLSHNRAKNRYGNIQAYDHSRVMLrgagSGCDYINATYIKDFDgtpkTYIAAQGPLESSCND----FWQMVWQEKCSVIVMLTGLIERNELKCHQYWP
 |.|  |. |||| .| .|||||| |    .|.||||| .|. ..    ..|| ||||.....|    ||.|.|.....|||||| |.|.. .||.||||
iallpenlsknrysdilpydhsrvkl....egsdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

stDQPaAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPH------VSESGPWIIHCSAGVGRT
  ..   || .|| |.. |...||||| |||.  .. ...||...|....||. |||. .. ||.| . ...           ...|| ..|||||||||
..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GIFLVIDAMLRQAkekKvVDIYNYVHSIEEDRPY-IIQTKDQYVFIHQTILE
| ..... ||..    . ||....|. . | ||. ..|| .||.|... .||
Gtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 11-252 7e-44 144.8 In-house 42-286 (305) alignment 
Range on Protein: 11-252
Range on HMM: 42-286/305.0
AAKLSHNRAKNRYGNIQAYDHSRVMLRGAGsGCDYINATYIKDfDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQ
| | . .. |||| ..   |. || |.|.    .|| | |.      || .| .| ||| .| ||| | .|.|   | ||  |.|.   ||..|..| |.
afkeaqeagknrykdvgcldnnrvklegpw.pheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdk

PAAY---G--VLTVSLK--KKEEF---SDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRsphvSESGPWIIHCSAGVGRT
.      .   ..| ..  .. .|   .. .|.   |  .|. ...| . .| .  || ||||    |.| . ..   |    .  || ..|||||.|||
dvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka..r....pskgpivvhcsagigrt

GIFLVIDAMLRQAKEKKVVD-IYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
|  .... .| |  . ....     .  | |.|   ||| .||.|.|| ||. 
gsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 11-177 2.8e-36 119.9 In-house 27-194 (297) alignment 
Range on Protein: 11-177
Range on HMM: 27-194/297.0
AAKLSHNRAKNRYGNIQAYDHSRVMLRGAGSGCDYINATYIKDFD-GTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTD
.|| .    |||| .| |.| .|| |... .. ||||| |.   |  ..  || |||||... .|||..|...   ||||.. | |    ||  ||||..
sakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

QPAAYG----VLTVSlKKKEEFSDYTVRSLLLSKQgtlKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNII
|         |  .| .  .||    .  | |  .   .| | ..  || |||  ||| .   | ||. ...
qerlkagdvvvefls.stsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvc
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 12-255 1.7e-86 284.5 In-house 4-244 (250) alignment 
Range on Protein: 12-255
Range on HMM: 4-244/250.0
AKLSHNRAKNRYGNIQAYDHSRVMLRGAG--SGCDYINATYIKDFDGTpKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELkCHQYWPsTD
||  .|. |||| .| |.|.|||.|        .|||||.... .|.. |..||.||||... .|||.||..|| ..||||| | | ..  .||||| ..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.ve

QPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEvRLIHQYQFTSWPHRGVPQQTAALLRFRKNIiNRSPHVSESGPWIIHCSAGVGRTGIFLVIDAM
..  || .||||..||||.|||.| | |||.   .| |.. |..|..|| .|||... | | ..|.. ..|   ....| |..|||||||.| |..|||.
kaekyGdvtvsllskeefadytkrklklskakkade.rivrqlhfvvWPdkgvPevatavLellkkv.qasqqqagnaPvivqCsaGvgrsGafiaidav

LRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIA
| ..|..||||...... . .|||  .....||||... ||.|| .
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0039614 (Phosphotyrosine protein) phosphatases II 12-253 1.2e-79 263.2 In-house 51-289 (297) alignment 
Range on Protein: 12-253
Range on HMM: 51-289/297.0
AKLSHNRAKNRYGNIQAYDHSRVMLRGAGS---GCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNElKCHQYWPST
|.|  |. |||| .| .|||||| | . ..   ..||||| |.. .| .....||.||||.....|||.|||.....|||||| |.|..  ||.||||..
allpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpee

DQpaAYGVLTVSLKKKEEFSDYTVRSLLLSKqgtLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGIFLVIDA
 .   || .|| |.| |. ..|||| | ...    .|.| ....|.|.||. |||. .. ||.| . . ..  . ...|| ..|||||||||| |.... 
gg..tygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaayl

MLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
||.| .... ||... |. . | ||...|| .||.|... .|| |
mleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 12-251 2.2e-59 195.7 In-house 15-262 (270) alignment 
Range on Protein: 12-251
Range on HMM: 15-262/270.0
AKLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTD
 .  .... ||| .|    ..||.|      |   |||| |.. ||| .|.||||.|||... ..||.|.|.|| . |||.||| |..  || .|||.  
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

QP---AAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTlkEVRLIHqYQFTSWPHRGVPQQTA------ALLRFRKNIINRSPHVSESGPWIIHCSAGVGRT
.     ..| ..|   ..|  . | .. | | ..|.  | ||.| .....|| .|||...        ||.  ... . . . ....|...|||||||||
kekvkledgkikvlalseekeegyiltrlrleekge..errlvH.fwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
|.....| ..|  .|.| ||. . .. . .||. ..|. .|| |......|
GtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 12-98 4.2e-09 30.3 In-house 29-115 (332) alignment 
Range on Protein: 12-98
Range on HMM: 29-115/332.0
AKLSHNRAKNRYGNIQAYDHSRVMLRGAGSGCDYINATYIKDFDgTPKTYIAAQGPLESSCN-DFWQMVWQEKCSVIVMLTGLIERNE
 |.  |   ||   . ..||||| |       |. ||...  .     .|| || |..   .  ||.|| . | |.|...  . |...
dkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgys.kksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 13-261 2.2e-73 242.1 In-house 39-284 (515) alignment 
Range on Protein: 13-261
Range on HMM: 39-284/515.0
KLSHNRAKNRYGNIQAYDHSRVML--RGAGSGCDYINATYIKDFDGtPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPS-TD
.   |  ||||.||  || .|| |         ||.||.||. ||   |.|||.|||...| .|||..|.||. . |.|.| | | .  || .|||    
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

QPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTlkeVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVSESGPWIIHCSAGVGRTGIFLVIDAM
.   .| . |.|   |  .. . | | . |.     .| . |..|| ||..|||..| .||.. |..  .. |   . | ||||||||||||... || .
dsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikev..kadhgqythpliihcsaGvGrtGvvisidsv

LRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIK
. .||. ..||..|.|. | ..|||..||..|| ||....|| |   |  | 
vahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlip
0042113 (Phosphotyrosine protein) phosphatases II 13-251 3.4e-72 238.1 In-house 5-241 (245) alignment 
Range on Protein: 13-251
Range on HMM: 5-241/245.0
KLSHNRAKNRYGNIQAYDHSRVMLRGAGSG--CDYINATYIkDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPStDQ
.| .|. |||| .| .|||.|| |   |.   .||||| |. |..  ....||.||||.....|||.|.|......||||| . |..  ||.||||. ..
llpenkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

PAAYGVLTVSLKKKEEFSDYTVRSLLLSKQgTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHvSESGPWIIHCSAGVGRTGIFLVIDAML
.  || .|| |.. | ..||||| | ...    .|.| ...|....||. |||  .. ||.| . . .     ...|| ..|||||||||| |.... ||
sltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylml

RQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.|... . |.... |. . . || ..|| .||.|... .||
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 13-260 8.3e-63 206.9 In-house 29-273 (283) alignment 
Range on Protein: 13-260
Range on HMM: 29-273/283.0
KLSHNRAKNRYGNIQAYDHSRVMLRGAGSgcDYINATYIK--DFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQ
  ..|. |||. .| ..|  || |.      |||||..|   . .   | ||.||.||.    |||.||..|| . ||||| | | .. || ||||.   
sadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs

pAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphVSESGPWIIHCSAGVGRTGIFLVIDAML
   || .||.|.|      .... ||| .... |.  |.  ||.  | . |      .|..| | | ..    |. || ..|||.|.|||..|. . | .
.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqt..eskkgPivvhCstgiGrtavfiaasasv

RQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRI
 .|. . |||... |. . |.|. ..||.||| ..|. .||  .. . .|
kdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqi
subfamily_CG7180_pd Subfamily CG7180 13-256 1.3e-55 183.2 In-house 38-293 (296) alignment 
Range on Protein: 13-256
Range on HMM: 38-293/296.0
KLSHNRAKNRYGNIQAYDHSRVMLRGA--GSGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNElKCHQYWPSTDq
  ..|| |||. ..  ||. ||.|.     .  |||||.|.  |   .| ||  ..| ... ..||..|..|..| .|.||   . .. ....||| .  
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

PAAYGVLTVSLKKKEEFSDYTVRSLLLSKQ---------GTLKEVRLIHQYQFTSWPH-RGVPQQTAALLRFRKNI---INRSPHVSESGPWIIHCSAGV
 . || . | . ....... . | . | |.         .   |.|.....|.| |.    ||  |.||. .|. .   ... ..  | || ....| |.
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAE
.|.|..| ||| | ...... ||....|  . ..|| .......| .| ...|||....
sRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 13-258 3.7e-47 155.8 In-house 37-282 (307) alignment 
Range on Protein: 13-258
Range on HMM: 37-282/307.0
KLSHNRAKNRYGNIQAYDHSRVMLRGAGSGCDYINATYIKdFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTD-QP
 .| |  |||| .... |..|....  |   ||| | |.      || .|.||||||..  .|| |. |||   ..||  .||  ..||.||||  . | 
afsantdknryqdvkcqdkgrivvkfdglasdyihanylg.iaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

AAYGVL--TVS---LKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLrfrkNIINRSphVSESGPWIIHCSAGVGRTGIFLVI
 ..|    |.|   |  |.   |  .  .   |    .. | |...|.. || |||||   . .    |...      .  | ..||||||||.|  . |
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltai....nlleav..rydtnpvvvhcsaGvGrsGtivai

----DAMLrqaKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENK
    | |.   . .   |. . |. . ..|.| |||. ||...|. .|| ..   |
slvqdkmi...aGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 13-255 1.5e-21 71.3 In-house 43-281 (303) alignment 
Range on Protein: 13-255
Range on HMM: 43-281/303.0
KLSHNRAKNRYGNIQAYDHSRVMLrgagSGCDYINATYIkDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQPA
.. .|  |||. ..   |||.| |    |   || |.|. ..| . |  | .| ||  .. |||||. ..|  ....|    | ..|  .  .|  ..  
qfvknmdknrfvdvicldhskvkl....sdssyihasyl.eld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

AYG--VLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYqfTSWPHRGVPQQTA-ALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGIFLVID-A
 .   .. |   |. |..|  |  .|   .|. |    .|.|   .|||  .| ...  ...   ..     . |.| | .    .|.||.| | ... |
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhy..kawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

MLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIA
 |   .|.  .|. . .  . . | . .|   |. ...  . | .. 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 14-258 1.1e-77 256.2 In-house 43-288 (305) alignment 
Range on Protein: 14-258
Range on HMM: 43-288/305.0
LSHNRAKNRYGNIQAYDHSRVMLRGAGSGC--DYINATYIKDFDGTpKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQ-
 ..|.||||. .|. .|..|..|.   |    |||||.|.. ...  |.||.|||||..  .|||.....|| |.|||||.|.| .. ||.|||| . . 
keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskte

PAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSpHVSESGPWIIHCSAGVGRTGIFLVIDAML
.  .| ..| || ....|||. | | .|.. . || | . |||.|.||  ||||....||.. |.. ..  . ..  | ..||||||||||.|...| .|
kkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdq.kkdkgvpllVhCsagvgRtGvfiavdial

RQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENK
 ..|. .|||...... . . |....||.|||||.|. . | ... . 
erlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdt
0045098 (Phosphotyrosine protein) phosphatases II 14-252 2.1e-75 249.0 In-house 30-271 (278) alignment 
Range on Protein: 14-252
Range on HMM: 30-271/278.0
LSHNRAKNRYGNIQAYDHSRVMlrgagsgcDYINATYIKDFdgtPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPStDQPAA
.  |..|||| .|..||||||         |||||.||. .   ||..||.||||.| ..|||.|.|.....||||||.|.|..  ||.||||. ...  
ylgnldknRykdilpydhsrVk........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggslt

YGVLTVSLKKKEEFSDYTVRSLLLSKQ---GTLKEVRLIHQYQFTSWPHRGVPQQT--AALLRFRKNIINRSP-----------HVSESGPWIIHCSAGV
|| .|| |.. |...|||.| ||.       .  | | ........||  ||| ..  . .|.. . | ..             . ...|| ..||||||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

GRTGIFLVIDAMLRQAkeKKVVDIYNYVHSIEEDRPY-IIQTKDQYVFIHQTILEA
|||| . ... ||..   ...||....|. . . ||. ..|...||.|... .|| 
gRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 15-251 6.1e-164 537.8 In-house 1-237 (237) alignment 
Range on Protein: 15-251
Range on HMM: 1-237/237.0
SHNRAKNRYGNIQAYDHSRVMLRGAGSGCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQPAAY
|.|..|||||||.|||||||.|.|||||.|||||||.|.||||||.||||||||||||.||||||||||||||||||||||.||||||.|||||||||||
senkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGIFLVIDAMLRQAK
|||||||||||||||||||||||||..|||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

EKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
|||||||||||.|||||||||||||||||||||||||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN23_pd Subfamily PTPN23 15-253 3.9e-65 214.5 In-house 41-280 (288) alignment 
Range on Protein: 15-253
Range on HMM: 41-280/288.0
SHNRAKNRYGNIQAYDHSRVMLRgaGSGCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPS-TDQPAA
  .  |||. .|  |||.||.||  ||  |||||...||   .  ..||.|.||.|. ||||.||...| ||||||.   |... |...|||. ....  
klyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKeVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIIN--RSPHVSESGPWIIHCSAGVGRTGIFLVIDAMLR
.| |.|.||...| . .  | | |. ... . |. .   |.||||. |||.    ||.| ... .  .. .     | ..||||||||||.| .. | .|
fgdlsvtlksvretethvervlkletldada.vksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

QAKE-KKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
. .. . ..|| . |. . |.| . .|.|.|. |  . .||| 
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 15-256 3.4e-64 211.6 In-house 45-281 (287) alignment 
Range on Protein: 15-256
Range on HMM: 45-281/287.0
SHNRAKNRYGNIQAYDHSRVMLRgaGSGCDYINATYIKDFDGTpKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQpAAY
|.|. |||. .|  .|  ||.|.  |   |||||..|. .    | .|.|..|. .   .||....... ..||||. . | .| .|.||||...    .
sqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvl

GVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRG-VPQQTAALLRFRKNIinRSPHVSESGPWIIHCSAGVGRTGIFLVIDAMLRQA
|  ...| ..|  ..|..| | . ...  .. . ..|||.|.|. .| |... . || . . .  .. . .  .. ..|||..|||...|. ..  ....
GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy..ktqrkrgntsivvhCsdtvGrsamfcaaattinkc

KEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAE
|.  |.|... ..|    .|  .|| .|| || . .|| | . 
kteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 15-254 6.4e-57 187.9 In-house 46-280 (439) alignment 
Range on Protein: 15-254
Range on HMM: 46-280/439.0
SHNRAKNRYGNIQAYDHSRVMLRG--AGSGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNElkchqYWPSTDQpA
.....|||| .. |.||.||.|.         |||| ||| .  ..| |||.||| . ...|||..|...|.. ||||| |.|        |||| .. .
eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.v

AYGVLTVSLKKKEEFSDYTVRSL-LLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNiINRSPHVSESGPWIIHCSAGVGRTGIFLVIDAMLR
 || ..|   .. |. .|..| . .. .. | .  | . |.....||.. || |.. .| | .  || .    | || ..||||||||||  . .|  | 
cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflra.insandkeeygpvvvhcsagvGrtGtiialdiale

QAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALI
| | .. |||   |. . ..|  ..|.  |||||....|| ..
qlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 15-254 3.1e-52 172.2 In-house 38-294 (301) alignment 
Range on Protein: 15-254
Range on HMM: 38-294/301.0
SHNRAKNRYGNIQAYDHSRVMLRGAGS----GCDYINATYIKDFDGTpKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTD-
..|.| ||. ||. ||. |..|.   .      .||||.||...  . | .||||||...   |||...|||| . |||.|.| |. . ||.||||... 
eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea

QPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQG--------------TLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSeSGPWIIHCSA
.   .| .|| |...  . |...|.| .  |               . |. . . |.| |.||. || .. .  |.   ..| |   ..  || ..|||.
eseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkig.ggpvvVHCSd

GVGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALI
.|.|.|..  ..  | |.|   |||... ....   .|  ..| .||..|.. | . | 
tVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 15-252 2.7e-42 139.6 In-house 31-258 (267) alignment 
Range on Protein: 15-252
Range on HMM: 31-258/267.0
SHNRAKNRYGNIQAYDHSRVMLRGAGSgcDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNelkCHQYWPST-DQPAA
..|...||. .   ||..||.||      .||||.|.. .  | ...|. |.||. .  ||.... ..|..|||.||   . |    ...||    |   
eknqernrlddnlpyddtrvilrtkee..eyinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakk

YGVLTVSLKKKEEFSDYTVRSLLLS-KQGTLKEVRLihqYQFTSWPhrgVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGIFLVIDAMLRQ
|  |||    ..|  || . .| |  |. . ..| |   | .  |    .  .    |.    |. .      . | ...||.||||.| |||||..|..
yqdltvehslekeendyqiitlelkfknesahnvtl...yyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqler

AKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
||.  |.||....  | . |. ...||..|..||... | 
aktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 15-257 3.8e-33 109.7 In-house 41-275 (288) alignment 
Range on Protein: 15-257
Range on HMM: 41-275/288.0
SHNRAKNRYGNIQAYDHSRVMLRgagSGCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPST-DQPAA
  | ...|| |.   | .|| |      .|.  |. .      ..  | || ||..  . .|.|. ..    ||||. |.|.   |  .|.||   . | 
ianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinrsphVSESGPWIIHCSAGVGRTGIFLVIDAMLRQA
.| |    ||| .  | .|.  ||  . . .|  .. .  .  |.. |||..  . ||. . .       |   | ..|.|||||||| . .|  .|...
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialesl

KEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAEN
. .  . | . ...  |.|   |||. ||...|. .|| |.   
rlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 15-252 2.1e-31 103.7 In-house 50-289 (310) alignment 
Range on Protein: 15-252
Range on HMM: 50-289/310.0
SHNRAKNRYGNIQAYDHSRVMLRGAGSG-CDYINATYIKDfDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQPAA
 ..  |||| ..   | ||| |.   |   ||| | |.|  .   .|.| .||||. .  |||.|..||..  |..|    |    ||  ||||     .
kkymhknrysdvvcldtsrvklkidksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGVLTVSL--KKKEEFSDYTVR------SLLLSKQ-GTLKEVRlIHQYQFTSWPHRGVPQQTAALLRFRknIINRSPHvsesGPWIIHCSAGVGRTGIFL
||.. |.   .  |||    .        . . .|   |||.| .   ..  || ||||..    .  |  .. .  |    || ..|||||..|... .
ygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelr.vslikwpnwpdrgvpdekchtvpqr..llaqvrh....gpcvvhcsagkdrlyvvv

VIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
 ..  . .... . ||. . .  .  .|   |||. ||..|..  .  
alklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_egg_pd Subfamily egg 15-250 2.7e-26 87.0 In-house 38-267 (307) alignment 
Range on Protein: 15-250
Range on HMM: 38-267/307.0
SHNRAKNRYGNIQAYDHSRVML---RGAGSGcDYINATYIKDfDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNelKCHQYWPST-DQ
. |. | |   ..  | ||| |   ||  .. |.| | ..|  .    ..| || ||  . .|||.||.||..  |||||   | .  .|. ||| . ..
dnnlekarskrvhckdssrvklelrrGqyld.dfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpkaesd

PAAY--GVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFtSWPHRGVPQQTAALLRFRKNIinrsphvseSGPWIIHCSAGVGRTGIFLVIDA
.. .  | | .   | .. .|   |   |   |. .| | .  .|   . . .       .||  .|.         | | ....  || ... .. |. 
slvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnl.........skpvvvqdilGvskaatlvaiei

----MLRQAKEKKVvdIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
    .||    | .  . . |  .   |.. ...  .|.|... .|
allsllrGpitksl..vlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 15-90 2.3e-09 31.3 In-house 35-116 (347) alignment 
Range on Protein: 15-90
Range on HMM: 35-116/347.0
SHNRAKNRYGNIQAYDHSRVMLRGAGS-------GCDYINATYIKdFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVML
 .. .|||  . .  | .||.|    |          ||||..|| || . | || .| || ..  |||.||   | . .| .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 15-66 1.9e-07 25.2 In-house 46-95 (95) alignment 
Range on Protein: 15-66
Range on HMM: 46-95/95.0
SHNRAKNRYGNIQAYDHSRVMLRGAgSGCDYINATYIKDFDgTPKTYIAAQG
  |  |||. ||  || .||.|       ||||| ..  .    . ||||||
eanipknrflnifpydatrvvlttk.rdsdyinacfvdgya.rkncyiaaqg
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 16-255 4.8e-36 118.9 In-house 36-271 (281) alignment 
Range on Protein: 16-255
Range on HMM: 36-271/281.0
HNRAKNRYGNIQAYDHSRVMLRG---AGSGCDYINATYIKDFdGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQP-
 |  |||| || . | ||| |.         ||| | ||.      . || .||| . .  |||.|.|||. . ||||  ..| |  || .|.|   .  
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirsp.flkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

AAYGVLTVSLKKKEEFSDYTVRSLLLSKQGtlkEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphvsesGPWIIHCSAGVGRTGIFLVIDAMLR
  .  |.|| .            | || .|   | ||| .. .  ||   ||. .  .|.  ..|  ||       | .|||||||||.| .. ..  |.
lqfdklsvsyedstvnkslvttrlnlsyeg...etrlithwlwkewpdwqvpessevmlkilrkirars......tppvihcsagvgrsgtlmaveialq

QAKEK-KVVDIYNYVHSI-EEDRPYIIQTKDQYVFIHQTILEALIA
  . .  . || . |  .    |   .|| .||..| . .|.  .|
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgva
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 16-257 2e-30 100.8 In-house 34-274 (285) alignment 
Range on Protein: 16-257
Range on HMM: 34-274/285.0
HNRAKNRYGNIQAYDHSRVMLRGAgsGCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPST-DQPAAY
 |   ||| .... . .||.|.      ||| |....       |||..||||  . .|||.|..||| . ..||  |.|    ||  |.|    .   .
anpdlnryadvrcieetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GVLTVSLKK-KEEF-SDYTVRSLLLS-KQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHvseSGPWIIHCSAGVGRTGIFLVIDAMLR
|   ..| . |||  .   . .| .   . .  |   . . |   || .  |...  .. . | . .  |.     |  .|||||||||  |. ||    
gkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk...ekpicvhcsagvgrtatfvgidyati

QAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAEN
.  |.  ... . |. .   |   .|.. |..|..  ..| .| | 
rimenpniemldivremramrfqavqshmqflflyvvlmeyfigeg
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 16-265 2.5e-26 86.8 In-house 50-294 (302) alignment 
Range on Protein: 16-265
Range on HMM: 50-294/302.0
HNRAKNRYGNIQAYDHSRVMLRGAgsGCDYINATYIKDFDGTpKTYIAAQGPLESSC---NDFWQMVWQEKCSVIVMLTGLIERNElKCHQYWP-STDQP
.| .||.  .....|. .| | ..    .|.||. ..  . | .. | || |  .|    ..||.||.|||.  .|.| |  | ..   ....|  ... 
knlkknqsedvpildsnlvkleae..pdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

AAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSEsgPWIIHCSAGVGRTGIFLVIDAMLR
  || . |  .| |. .. . |  .        .  |.  | .| |..  ||.. |.| .  ... ... ...|  . .|    |.|| |.||.  . . 
keygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikade..ntvivSknGaGRagafltlavave

QAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILeALIaeNKRIKRPHL
. ...| . | . |.|| ..|| .... .|||... ..|  .|   |....|. 
klqkgkepnikeivksiRsqRpravdslkQyvslyiall.lyi..kkkvtkpee
Y_phosphatase Protein-tyrosine phosphatase 17-251 3.1e-80 264.3 Pfam-A 1-235 (235) alignment 
Range on Protein: 17-251
Range on HMM: 1-235/235.0
NRAKNRYGNIQAYDHSRVMLRGAGSGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWP-STDQPAAYG
|. |||| .| .||..|| |.| .. .||||| |.| .. ..|..||.||||.|...|||.||||||..|||||| | |... ||.|||| .....  ||
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

VLTVSLK-KKE-EFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphVSESGPWIIHCSAGVGRTGIFLVIDAMLRQA
 ..| || |.. . ..||.| | |.|... .| | ..|...|.||..|||... .||.. ... ...   ..||| ..||||||||||.|...|..|.|.
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleql

KEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.... ||....| .. . || ..|. .||.|....|||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 17-251 3.1e-80 264.3 In-house 1-235 (235) alignment 
Range on Protein: 17-251
Range on HMM: 1-235/235.0
NRAKNRYGNIQAYDHSRVMLRGAGSGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWP-STDQPAAYG
|. |||| .| .||..|| |.| .. .||||| |.| .. ..|..||.||||.|...|||.||||||..|||||| | |... ||.|||| .....  ||
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

VLTVSLK-KKE-EFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSphVSESGPWIIHCSAGVGRTGIFLVIDAMLRQA
 ..| || |.. . ..||.| | |.|... .| | ..|...|.||..|||... .||.. ... ...   ..||| ..||||||||||.|...|..|.|.
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleql

KEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILE
.... ||....| .. . || ..|. .||.|....|||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 17-260 4.3e-45 148.9 In-house 1-178 (182) alignment 
Range on Protein: 17-260
Range on HMM: 1-178/182.0
NRAKNRYGNIQAYDHSRvmlrgagsGCDYINATYIKdFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTgliernelkCHQYWPstdqpaaygv
|. |||| .|  |||||        ..||||| ..  ..  ....||.|||| |...||..|........||.||         ...|||          
nldknrysdilpydhsr........dldyInanlyl.gslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

ltvslkkkE-EfsdytvrslllskqgtlkeVRLIHQYQFTSWPHRGVPQqTAALLRFRKNIINrsphvsESGPWIIHCSAGVGRTGIFLVIDAMLRQake
        | .                    ||..||....||  |||  .  ||.| . ...      |.|| ..|||||||||| . ... |...   
........ell...................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl...

kKvVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRI
 . |.... |. . . || ...| .||.|... .|| |   . |.
.g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 17-257 5.4e-40 131.9 In-house 55-293 (305) alignment 
Range on Protein: 17-257
Range on HMM: 55-293/305.0
NRAKNRYGNIQAYDHSRVMLRGAGsGCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQP-----
. .|||| .. . |.| | |      .||| | |.       | .|.|||||. . ..|| || |.|   ||||   .|   ||| |||| .        
aitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

AAYGVLTVSLKKK-EEFSDYTVRSLLLSKQGTLKevRLIHQYQFTSWPHRGVPQQTAALLRFRKNIinRSPHVsesgPWIIHCSAGVGRTGIFLVIDAML
.   |  ||  |  |  ..  .  | |.  |  |    . . |.| || ||||    . | .   |  |  .|    | ..|||||.||||  . |. .|
sgivvenvsgskpmerdaeiqitllnltysgdqk..msvrhlqwtewpdrgvppckltslellsai..rgskv....pivvhcsagigrtgtivaieyil

RQ-AKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAEN
 . |..|..  . . |... ..| . ||.  ||.|||. .|. ..   
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 18-256 7.3e-32 105.3 In-house 44-279 (312) alignment 
Range on Protein: 18-256
Range on HMM: 44-279/312.0
RAKNRYGNIQAYDHSRVMLrgAGSGCDYINATYIKdFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTD------QP
.  ||| ||| .|  |  |  ||    || | ..|     |. ....|||||..|  |||..    .. |..|.|..|    || .|           . 
kdlnrypniqcwdrgrftl..agdenfyihanfvk.ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

AAYGVLTVSLKKKEEF-SDYTVRSLLLSKQGTLKEVRLIHqYQFTSWPHRGVPQQTAALLRFRKNIINrsphvsESGPWIIHCSAGVGRTGIFLVIDAML
  |      ..         | | | .  . | .| .| | ||..|||  |.|.   . ||.   . .      .  | | |||||||||| . .|..|.
rvyteycteieiggkskdkithrvlkvvvkatgqesklnh.yqwaswpdhgmpdscdtalrllsavkk......dkkpviahcsagvgrtgtlaliesmi

---RQAKEKKVVDIYnyvHSIEEDRPYIIQTKDQYVFIHQTILEALIAE
   |. . ..| |..     .  ||   ...  |||.  ...|| | ..
aalrhprkqnvkdsf...vllrkdrarsvrvfpqyvyalrcvleflysk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 18-109 2.4e-24 80.7 In-house 48-154 (350) alignment 
Range on Protein: 18-109
Range on HMM: 48-154/350.0
RAKNRYGNIQAYDHSRVMLR----------GAGSGCDYINATYIKDF----DGTPKT-YIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCH
 ||||| ||  |.|||| |.           . |. ||||| |.|      .  |.  |||.|.|| |  .||.... . |  ||..|| ..| |  ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPSTD
.||.  .
rYWqegs
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 18-122 6e-14 46.1 In-house 49-166 (349) alignment 
Range on Protein: 18-122
Range on HMM: 49-166/349.0
RAKNRYGNIQAYDHSRVMLRGA-------------GSGC---DYINATYIKDFDGTP-KTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELK
 ||||| .|  |.||||.|. .               ..   ||||| |.|    .. | ||| | || |. .||....  ..  ... |.   | .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHQYWpstdQPAAYGVLTVSLK
|..||    |  .|   || |.
cdiyw....qelsysnitvklq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 19-252 8.4e-45 147.6 In-house 58-282 (290) alignment 
Range on Protein: 19-252
Range on HMM: 58-282/290.0
AKNRYGNIQAYDHSRVMLRGAGSGcDYINATYIKdfdGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTD-QPAAYGVL
 |||| ..   | .||.|.  . | ||. | |.|   |.  ..| .||.|...  |.|.|| ||| ..||||  |||    ||.||.| .. .  ..| .
kknrykdvvcndktrvilkdGydG.dyvhanyvk...GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGei

TVSLKKKEEFSDYTV-RSLLLSKQGTLKEVRLIHqYQFTSWPHRGVPQQTAALLRFRKNIinRsphvSESGPWIIHCSAGVGRTGIFLVIDAMLRQAKEK
||   ....  . .. . | . .. . || .| | ..  ||| . |.. | ||||  . .  |      ||| ..|||||.|||| |  |.. |.   . 
tvlcseeddkdaniikktlsvrdkdsGkehklkh.lkikswpdksvalstlallrtlril..r....kasGpvvvhcsaGiGrtGtfvaievglqilldG

KVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEA
| .|. . | .. . |   .|   ||. . . .|. 
keldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 19-256 1.7e-32 107.4 In-house 52-284 (301) alignment 
Range on Protein: 19-256
Range on HMM: 52-284/301.0
AKNRYGNIQAYDHSRVMLRGAGSGCdYINATYIKDFdGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPST-DQPAAYGVL
 |.|| ..    .. | .   |     | | .|.   | |. .||.||||.....||| |. | .   ||||.  .|..| ||..| |..  .    |  
dkhryptvPckPstavevivdGkrv.Pihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

TVSLKKKEEFSDY-TV-RSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFrKNIINRSphvseSGPWIIHCSAGVGRTGIFLVIDAMLRQAKE
.. .|.||   .  .. |.| .       . | .  ||...|..||||.  | |  .  ... .|       | ..|||||.||.  |.  . . |. . 
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdl.melvkks.....ekPivvhcsaGiGrsvafigteylarevea

KKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAE
.. ... . .. . |.|   .||. |  ..    .  || |
dptieltealkhlrehrwngvqtnsqlywmtlGtvyrlike
subfamily_CG42327_pd Subfamily CG42327 19-170 1.1e-27 91.6 In-house 30-184 (319) alignment 
Range on Protein: 19-170
Range on HMM: 30-184/319.0
AKNRYGNIQAYDHSRVMLRGAGS--GCDYINATYIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPST---DQPAA
 |.|. |.    ..||.|.  |.     |..|.|.. .| .|  ||||| .||.|  |||..||. .  ||| || | |    .| .|.|.    |.  .
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YGVLTVSLKKKEEFSDYTVRSLLLsKQGTLKEVRLIHQYQFtSWPHRGVPQQTAALL
|| . |.||..|    | . .||| |.   .| | .  | .  |.. .|| . |||.
yGdilvtlkgrevkdryaistlll.krvdkeesrelthywy.kwleaevPaeeaali
subfamily_eak_pd Subfamily eak 19-261 1.1e-19 65.0 In-house 54-313 (332) alignment 
Range on Protein: 19-261
Range on HMM: 54-313/332.0
AKNRYGnIQAYDHSRVMLRGAGSG-CDYINATyIKDFDGTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTD-QPAAYGV
 .| .. |  ||.  | |  .      ||||. . .|    . || .  . |.    ||||| ..|   ||.|   .| .  |  .|.|    .   .|.
nrnvvk.ivpydrylvrltssqlnrlGyinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGi

LTVSLKKKEEFSDYTVRSLLLSKQgtlKEVRLIHQYQFTSWPHRGVPQQT--AALLRF-----------RKN-----IINRSPHVSESGPWIIHCSAGVG
| |  |.  . . . .| | |||     |   .. |..  |    .|.     || .             |.     ....  |   |   || .. |  
ldverkefvkrniletrllelskG...nethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsa

RTGIFLVIDAMLRQ--AKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIK
|.|.|.||| ..|   .| | .  . ...  . . | . . .. |. ||.. .|. |   |.|..
raGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 26-261 8.6e-20 66.0 In-house 27-267 (290) alignment 
Range on Protein: 26-261
Range on HMM: 27-267/290.0
IQAYDHSRVMLRGAGSG--CDYINATYIKDFDGTpkTYIAAQGPLESS-------CNDFWQMVWQEKCSVIVMLTGLIERNEL----KCHQYWPS-TDQP
.    ..||.|.| |.    ||| | ...  .|     |. | |.|          ..|| |. |||   .|||    |...      | .| |   .. 
vpLveatrvvLkgygkrfnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee

AAYGVLTVSLKKKEEFSDYTVRSLLLsKQGTLKEVRLIHqYQFTSWPHRGVPQQTAALLRFRKNIINrsphvsESGPWIIHCSAGVGRTGIFLVIDAMLR
  .. |||. |.||.  |  .| |.. | .  .|  . | ... .| .. |...|  ||   ... .      .  | |.||  |. |  ..  |.    
lkfkgltvkCkskekeddvetRelvv.kfddeeeftvtH.sllkgWnklnvqedtktllsliqkvka......sktpvivHcvdGiSrsAalaaiilgyQ

QA-KEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEALIAENKRIK
   . .. | . . .... . |   |... .. |.   |.  .| . ... 
kiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfa
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 29-162 2.6e-11 37.9 In-house 5-126 (130) alignment 
Range on Protein: 29-162
Range on HMM: 5-126/130.0
YDHSRVMlrgagsGCDYINATYIKDFDGTpKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNElkchqYWPSTDQPAAY-GVLTVSLKKKEEF
.. ||.       | .|||| ..   . | . |. .| ||  .. |||.|. .    |.|.|  . | .|     ||| ..    |   ..|.| ...||
fevsrlq......gntyinasfvGllgrt.aeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdef

SDYTvRSLLLSKQGTLKEVRLIHQYQFTSWPHRGV
      | |  ..   .  . .  .| . ||  | 
knik.asnleiesdlneshqaltmfqisnwpsdgt
0046846 (Phosphotyrosine protein) phosphatases II 34-251 2.8e-37 123.5 In-house 3-171 (176) alignment 
Range on Protein: 34-251
Range on HMM: 3-171/176.0
VMLRGAGSGCDYINATYIKDFdgtpkTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPStdqPAAYGVltvslkkkeefsdytvr
..|.| . ..||||| .|         .|| ||||.... ||..|.........|.|| ..| . |||..|||      ..|.                 
lrllgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.................

slllskqgtlkevrlihQYQFTSWPHRGVPQQtAALLRFRKNIINrspHVSESGPWIIHCSAGVGRTGIFLVIDAMLRqakeKKVVDIYNYVHSIEEDRP
                 ||... ||  |||.  ..||.. . | .   ...| || ..|||||.|||| ..... . .    .| ..... .. . | ||
.................qylhlpwpDhgvpdl.elllellefire...alkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRp

-YIIQTKDQYVFIHQTILE
 ...|| .|| |... .|.
lgavqtpeQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 41-247 3.5e-37 123.1 In-house 3-155 (172) alignment 
Range on Protein: 41-247
Range on HMM: 3-155/172.0
SGCDYINATYIKDFDgTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLiernelkchqywpstdqpaaygvltvslkkkeefsdytvrslllsKQ
.|.||||| |..     |. .|| |||| . ..|||.|........||.||.|                                               
egsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly

GTLKEVRLIHQYQFTSWPHRGVPqQTAALLRFRKNIINRSpHVSESGPWIIHCSAGVGRTGIFLVIDAMLrqakekKVVDIYNYVHSIEEDRPYIIQTKD
 . ...||. ||....||  |||  .. ||.| . | ..  ..|..|| ..|||||||||| . ... ||      . ..... |. . | ||...|...
dpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYVFIHQ
|| |...
qyrflyy
0044763 (Phosphotyrosine protein) phosphatases II 42-248 7.1e-30 99.3 In-house 17-166 (178) alignment 
Range on Protein: 42-248
Range on HMM: 17-166/178.0
GCDYINATYIKDFdgtpkTYIAAQGPlesscNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQpaaygvltvslkkkeefsdytvrslllskqg
..|||||..| ..      |.....|      |............||.||. .|.. |||..|||.                                  
rsdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............................

tlkevrliHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvSESGPWIIHCSAGVGRTGIFLVIDAMLRQakekKVvDIYNYVHSIEEDRPyIIQTKDQ
         ||... .|  |||. .. .|.| . | .  .  .. || ..||||||||.| . ... |...    .. .... .. . | || |... .|
........iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgq

YVFIHQT
. .... 
lrqLyef
0036282 (Phosphotyrosine protein) phosphatases II 43-247 5.3e-40 132.3 In-house 2-164 (174) alignment 
Range on Protein: 43-247
Range on HMM: 2-164/174.0
CDYINATYIKDFDGTPkTYIAAQGPLEsscndFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPStdqpaaygvltvslkkkeefsdytvrslllskqGT
 |||||.... .  ||  .|| ||||.     ||.|.........|||. ..|..  ||..|||.                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

LKEVRLIHQYQFTSWPHRGVPQQTAaLLRFRKNIINRSPHvSESGPWIIHCSAGVGRTGIFLVIDAMLRQAKeKKVVDIYNYVHSIEEDRPYIIQTKDQY
  ..||..||... || .|||  .  ||.| | . .   . ...|| ..||||||||||.. ... |||. .  ..||....|...   ||...|| .||
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

VFIHQ
 |...
rflyy
0051429 (Phosphotyrosine protein) phosphatases II 44-253 1e-51 171.5 In-house 5-225 (272) alignment 
Range on Protein: 44-253
Range on HMM: 5-225/272.0
DYINATYIKDFdGT---PKTYIAAQGPLESSCNDFWQMvWQEKCSVIVMLTGLIERNELKCHQYWP-----------STDQPAAYGVLTVSLKKKEEFSD
.|||| ... . |    |.......|||. ...|||.. .......||.|... ||. |||..|||           .....  || |.| | ..| ..|
gyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTaaLLRFRKNIINrsphvseSGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVD--------I
|..| |||... . .|.| ......|.|| .||||..  ||.. . . .       .|| ..|||||..|||.. ... .|..  .  .||        .
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

YNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
...|. . . ||...|| .||.|... .||.|
eeaveelraqrpgavqteeqylflyeallell
0051082 (Phosphotyrosine protein) phosphatases II 44-250 1.8e-34 113.9 In-house 4-150 (151) alignment 
Range on Protein: 44-250
Range on HMM: 4-150/151.0
DYINATYIKDFdgtpktYIAAQGPLEsscnDFWQMVWQEKCSVIVMLTGLIERNelKCHQYWPSTDqpaaygvltvslkkkeefsdytvrslllskqgtl
||||..|. ..      ... .|||.    ||...........||.|... ||.  .|..|.|...                                  
dyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

kevRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINrsphvSESGPWIIHCSAGVGRTGIFLVIDAMLRQakekkvVDIYNYVHSIEEDRPYIIQTKDQYV
   . ........||  |.|. ..|.|.| . ...      ..|| ..|||||.||||.. ... ||..      |...  .. . . ||...|...|..
...ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FIHQTIL
|... .|
fqlfall
0049260 (Phosphotyrosine protein) phosphatases II 56-247 7.9e-36 118.4 In-house 6-144 (152) alignment 
Range on Protein: 56-247
Range on HMM: 6-144/152.0
GTPKTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWpstdqpaaygvltvslkkkeefsdytvrslllskqgtlkevrlihQYQFT
. |. .||.|||.. ...|||.|... ....||||| | |...|||.||.                                             ||...
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhl

SWPHRGVPQQTAALLRFRKNIINRspHVSESGPWIIHCSAGVGRTGIFLVIDAMLrqakekKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
 ||  |||. .  || . . |  .    ...|| ..|||||||||| . ... ||      . |.....|  . | ||.......|. |...
pwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 59-247 1.2e-29 97.9 In-house 5-198 (199) alignment 
Range on Protein: 59-247
Range on HMM: 5-198/199.0
KTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQP-AAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLK-EVRLIHQYQFTS
. |||.| ||  .  |||||||.     |||.      .|     |||.|.   . || |.|. |     .|||. .|.|... |     | | .|||||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPHRGVPQqTAALLRFRKN--IINRSPHVSESGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKK--VVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
|  .  |.  | .. |      . .        | |.||| | | ||.|. .|  .|  .| |  |||...  . . . |  || . ..| ||.|
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 59-247 1.2e-29 97.9 In-house 4-197 (198) alignment 
Range on Protein: 59-247
Range on HMM: 4-197/198.0
KTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTDQP-AAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLK-EVRLIHQYQFTS
. |||.| ||  .  |||||||.     |||.      .|     |||.|.   . || |.|. |     .|||. .|.|... |     | | .|||||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPHRGVPQqTAALLRFRKN--IINRSPHVSESGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKK--VVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
|  .  |.  | .. |      . .        | |.||| | | ||.|. .|  .|  .| |  |||...  . . . |  || . ..| ||.|
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 59-147 2.5e-13 44.1 In-house 236-321 (440) alignment 
Range on Protein: 59-147
Range on HMM: 236-321/440.0
KTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLierNELKCHQYWPSTDQPAAYGVLTVSLKKKEEFSDYTVRSLLLSKQGTLKEVR
...||.| ||.|.  |||..| . . | |.||  |   |.  |  |||   .  ..| .||  |  |..    ||.| |  .  ..|.|
nafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheir
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 59-162 3.7e-08 27.3 In-house 137-235 (244) alignment 
Range on Protein: 59-162
Range on HMM: 137-235/244.0
KTYIAAQGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNElkchqYWPSTDQPAAYG-VLTVSLKKKEEFSDYTVRSLLLSKQgtLKE-VRLIHQYQFTS
  || .| ||  .  |||.|. . .  |.|.|  . | .|     ||| ..    |   .||.|  ..|| .     | .  .  ..|  . .  .| . 
aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplewyeeditvtltdrdefknikasnleiesd..mneshqaltmfqisn

WPHRGV
||  | 
wpsdgt
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 63-255 1.4e-19 64.7 In-house 92-290 (302) alignment 
Range on Protein: 63-255
Range on HMM: 92-290/302.0
AA---QGPLESSCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPSTD----QPAAYGVLTVSLKKK-EEFSD---YTVRSLLLSKQGTL-KEVRLIH
 .     |  |... .| .. | . ...| |....| .| || .|.        .   | | |||.|.. |||.|   ... .. .  . .  |  . ..
vskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvd

QYQFTSWPHRGVPQQTAALLrfrkNIINRSPHVSESgpWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
  .|..||. | |... . |    .|..      ..   ..|||||||||| .. |   .   ..||| |. . |  . . |   .|...| ...   . 
ilafsawpdhGapkeaytal....dilkfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvt

EALIA
 .|..
kglme
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 71-253 4.7e-20 66.7 In-house 40-221 (255) alignment 
Range on Protein: 71-253
Range on HMM: 40-221/255.0
SCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPS-TDQPAAYGVLTVSLKKkeEFSDYTVRSL-LLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAA
. . |.|.. | | .|.|||. . | .  ||..|.|   |.   .  ..|.  |    .|  .| | ..|. |  |. . .. |... |. .  |...  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LLrfrkNIINrspHVSESGPWIIHCSAGVGRTGIFLVIDA----MLRQAKEKKVVDIyNYVHSIE---EDRPYIIQTKDQYVFIHQTILEAL
.|    ||.     | .| . ..|||.|.||.  | ...     |.|. .. . |.. .|.  .|   . |.  |.|  |  |   ..|. .
il....nilk...vvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetvel.dylslleelrskrkraihtPlqlafsilmvldlv
subfamily_hpo-7_pd Subfamily hpo-7 71-254 1.4e-16 55.2 In-house 46-228 (263) alignment 
Range on Protein: 71-254
Range on HMM: 46-228/263.0
SCNDFWQMVWQEKCSVIVMLTGLIERNELKCHQYWPS-TDQPAAYGVLTVSLKKKEEfsDYTVRSL-LLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAA
  . |.|.. | | .|.|||.   | .  || .|.|   |.   .  ..|.  |  .  |  ...| |||  |  |... ...|... |...  |...  
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

LLrfrkNIINrspHVSESGPWIIHCSAGVGRTGIFLVIDA----MLRQAKEKKVVDIyNYVHSIEE---DRPYIIQTKDQYVFIHQTILEALI
 |    ||..    . .| . ..|||.|.||.  | |..     |.|. .. . |.. .|.  .||    |.  |.|  |  |   ..|. ..
il....nilk...varnskslvvhcstGiGrsaafsvaElvyqkmirsldttstvel.dylsLleelrssrkraihtPmqLafsilmvLdfvl
0048076 (Phosphotyrosine protein) phosphatases II 124-249 1.2e-19 65.8 In-house 22-139 (145) alignment 
Range on Protein: 124-249
Range on HMM: 22-139/145.0
KEEFSDYTVRSLLLSKQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINrspHVSESGPWIIHCSAGVGRTGIFLVIDAMLRqakeKKvVDIYN
 |.. |. .. .|     .  ..||. ||....|| .|||. .. ||.| . | .   ...| || ..|||||||||| . ... ||.    .. |....
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefiee...alkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vslee

YVHSIEEDRPYIIQTKDQYVFIHQTI
 .. . . ||..... .|. |... .
alelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 130-247 1.5e-19 65.6 In-house 31-139 (144) alignment 
Range on Protein: 130-247
Range on HMM: 31-139/144.0
YTVRSLLLSkQGTLKEVRLIHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPhvsESGPWIIHCSAGVGRTGIFLVIDAMLrqakEKKvVDIYNYVHSIE
.|| .|  .      . | ..||....|| .|||. .. ||.| . | .  .   |.|| ..|||||||||| . ... |.    ... ..... .. . 
ttvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvr

EDRPYIIQTKDQYVFIHQ
. ||..... .|. |...
srrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 145-260 3.6e-27 89.8 In-house 87-201 (440) alignment 
Range on Protein: 145-260
Range on HMM: 87-201/440.0
EVRLIHQYQFTSWPHRGVPQQTAALLRFRKNiINRSPHVSESGPWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVF
| | ..||.. .|| .|||. .. .|.. .. .| | . . .|| ..|||||.||||. ...|..||.||    .||.... |. ..|| ..|| .||.|
esrtlkqyhyqgwpdkgvpkfagpvlkmiqd.vnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHQTILEALIAENKRI
.|...||.|.. .  |
vheavlegllcgdtli
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 148-250 3.8e-11 37.3 In-house 216-341 (350) alignment 
Range on Protein: 148-250
Range on HMM: 216-341/350.0
LIHQYQFTSWPHR---GVPQQTAALLRFRKNIINRS-----PHVSESGPWIIHCSAGVGRTGIFLVIDAMLRQA-------KEK-------KVVD-IYNY
 ..| |.  |.       |..    |  ....|.        . ..| | ..||||||||||... .| .| .        ||        |. | |   
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VHSIEEDRPYIIQTKDQYVFIHQTIL
|  . . |  ..|..||..||....|
vnelrkqrismvqnldqfifiYeall
PTPc_DSPc_SM00012 149-251 4.4e-30 99.3 In-house 2-105 (105) alignment 
Range on Protein: 149-251
Range on HMM: 2-105/105.0
IHQYQFTSWPHRGVPQQTAALLRFRKNIINRSPHVSESGPWIIHCSAGVGRTGIFLVIDAMLRQAKEK-KVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQ
...|..|.||. |||... ..|.. ... .   . ..|.| ..||||||||||.| ..| .|.| ... | |||...|... . ||  .||..||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TILE
 .||
alle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 151-221 3.9e-07 23.7 In-house 222-302 (349) alignment 
Range on Protein: 151-221
Range on HMM: 222-302/349.0
QYQFTSWPHRGV---PQQTAALLRFRKNIINRS-----PHVSESGPWIIHCSAGVGRTGIFLVIDAMLR--QAKEKKVVDI
| |.  |.  ..   |.     |  ....|.        . ... . ..||||| ||||..  .| .|   .  ... . |
qlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnki
subfamily_CG42327_pd Subfamily CG42327 174-250 4.9e-19 63.1 In-house 235-312 (319) alignment 
Range on Protein: 174-250
Range on HMM: 235-312/319.0
KNIINRSPHVSESGPWIIHCSAGVGRTGIFLVIDAMLRQAKEK-KVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTIL
 || .|| . .. || ..||| ||||||. .  |  .|. .|  . ||| . |.|. .||   ..||.|| ||.... 
gnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_PTPDC1_pd Subfamily PTPDC1 186-248 1.6e-06 22.7 In-house 114-171 (182) alignment 
Range on Protein: 186-248
Range on HMM: 114-171/182.0
SGPWIIHCSAGVGRTGIflVIDAMLRQAKEkkvVDIYNYVHSIEEDRPYIIQTKDQYVFIHQT
 |   .|| || ||||.  .| ..|  ||.   ..  . .. . . ||  |||..|  .... 
egkvavhChaGlGrtGv..liacylvyakr...ltaekaiklvrskrpksiqtreqvelvkef
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 188-253 4.3e-14 47.1 In-house 230-295 (297) alignment 
Range on Protein: 188-253
Range on HMM: 230-295/297.0
PWIIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
. ..||||||||.|. .  |..| . . |.. |.   .. . | |. ..|| .|. .... .|. |
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 190-253 3.5e-16 53.3 In-house 2-65 (69) alignment 
Range on Protein: 190-253
Range on HMM: 2-65/69.0
IIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
..|||.| |||| |. |   . . | .|.|||.| |  .   || ..  . .|.||| .. |||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 190-253 8.6e-16 52.1 In-house 1-64 (69) alignment 
Range on Protein: 190-253
Range on HMM: 1-64/69.0
IIHCSAGVGRTGIFLVIDAMLRQAKEKKVVDIYNYVHSIEEDRPYIIQTKDQYVFIHQTILEAL
..|||.| |||| |. |   . . | .|.|||.| |  .   || ..  ...|.|||... |||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal