Gene NvecPTP-sf4-4 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP061_AA protein Get Run
NvecP061_AA_0-186 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-186 1.8e-110 362.8 In-house 1-179 (237) alignment
Range on Protein: 1-186
Range on HMM: 1-179/237.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrdgrSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
.||||||||||||.|||.||||||.|..    ||||||.||.|||||||||||||||.|.||||||||||||.||||||||||||||..|||||||.|.|
senkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQrvgdeGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHC
|..||..||||.|.|.|.|||||..|...||...     ..|.|.||.||.|||.||||...|.|||||.|||.|.|  ...|||.||
paaygvltvslkkkeefsdytvrslllskrltlk.....evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihc

subfamily_PTPRD_pd Subfamily PTPRD 1-186 1.1e-77 257.0 In-house 46-221 (564) alignment
Range on Protein: 1-186
Range on HMM: 46-221/564.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNq
|.|| |||| ||| |||.||||.   |.    |||||||...|.. ..|.|||.|||......|||.|||....|.||||| | | .|.|||||||... 
paNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.

PKPYGQYTVSLCKNEAFADYTVRTFLVtVRLQQQRVgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. ||..||.| ..| .|||..||| .  . ... .     | . |.||| |||.|||..||..|....|. . ..... |..|||
tetygeltVtleeeeeladyeirtfkl.kkkksses.....reVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhC

0050432 (Phosphotyrosine protein) phosphatases II 1-186 2.8e-64 212.7 In-house 66-239 (308) alignment
Range on Protein: 1-186
Range on HMM: 66-239/308.0
PENKIKNRYGNIVTYDHTRVVLkgpggnrDGRSDYINASYLQGFD-GTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-
|||| |||| .|. |||.||.|       |. |||||||| .|.. . |.|.||.||| . ...|||.|||.....|||||| |.| ..|||..|||.. 
penkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplel

-NQPKPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESrhNTAPWIVHC
 .... ||..|| | . | ..||||||. .|       .||.  |.....|.| ||| |||......|.| ... .    .  | .|||
gggsleygkftvtllseevlddytvrtleltn......lgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHC

0051299 (Phosphotyrosine protein) phosphatases II 1-186 7.5e-64 211.3 In-house 47-226 (288) alignment
Range on Protein: 1-186
Range on HMM: 47-226/288.0
PENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
|||. |||| .|. |||.||.|. ..|  .. ||||||||..|.. . | .||.||| . ...|||.|||.....||||||.|.| ..|||..|||. ..
penleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.gg

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRL--QqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. ||..|| | . | ..||||||. ||     .    ||.  |.....|.| ||| |||......|.| .....  ...  | .|||
sltygditvtllseevlddytvrtlevtnldlld....gdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHC

0046845 (Phosphotyrosine protein) phosphatases II 1-186 9.5e-64 210.8 In-house 26-211 (284) alignment
Range on Protein: 1-186
Range on HMM: 26-211/284.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASYLQGFD----GTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWP
|||. |||| .|. |||.||.|| ..|. .. ||||||||..|.|     ..||.||.|||.. ...|||.|||.....||||||.|.| ..|||..|||
penlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwp

DTNQPKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrvG-DEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR--HNTAPWIVHC
...... ||..|| | . | . ||||||. .|        | ..  |.....|.| ||| |||.... .|.| ... .  .  ..  | .|||
legevltygdftvtllseevkddytvrtleltnl......gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHC

0036941 (Phosphotyrosine protein) phosphatases II 1-186 1.6e-61 203.6 In-house 37-214 (297) alignment
Range on Protein: 1-186
Range on HMM: 37-214/297.0
PENKIKNRYGNIVTYDHTRVVLkgpggnRDGRSDYINASYLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-N
|||. |||| .|. ||||||.|       |. ||||||||..|. . ..|.||.||| . ...|||.|||.....|||||| |.| ..|||..|||.. .
penleknRykdilpydhtRVkl......ddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeg

QPKPYGQYTVSLCKNEA--FADYTVRTFLVTVRlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHC
... ||..|| | . |   ..|||.||. ||        |..  |.....|.| ||| |||.... .|.| ... .  ..  .  | .|||
esltygdftvtllsvevvllddytlrtlevtdt......gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHC

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-186 2.3e-61 202.1 In-house 7-182 (250) alignment
Range on Protein: 1-186
Range on HMM: 7-182/250.0
PENKIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEkCHKYWPdTNQ
|.|| |||| .|...|..||||.      |  |||||||.|.|.|.. | .||.|||....  |||.||..|  ..||||| | | .|. .|.||| ...
pqnkeknryadiialdssrvvLekek..gdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.vek

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRvgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH-NTAPWIVHC
.. ||. |||| ..| |||||.|.. .. . ....      | . |.||.||||||||..||||| ..||.  . .. ..|| ||.|
aekyGdvtvsllskeefadytkrklklskakkade......rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqC

0040438 (Phosphotyrosine protein) phosphatases II 1-186 6e-61 201.8 In-house 41-216 (317) alignment
Range on Protein: 1-186
Range on HMM: 41-216/317.0
PENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
|||| |||| .|. |||.||.|. .||  |  |||||||| .|.. ..| .||.||| . ...|||.|||.....|||||| | | ..|||..|||. ..
penkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.ge

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. ||..|| |.. |  |..|.||. |.        ||.  |.....|.| ||| |||.. . .|.| ... .  ...  | .|||
tltygdftvtllseeelagitlrtlevedl......gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHC

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-186 1.1e-59 197.2 In-house 54-230 (298) alignment
Range on Protein: 1-186
Range on HMM: 54-230/298.0
PENKIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASYLQGFDGTPkKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNq
|||| |||| .|...|..||||.      |  |||||||.|....|..  .||.|.|....  |||.||..|  ..||||| | | .| |.||||||.. 
penkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdeg.

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQqrvgdeGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT-APWIVHC
 . ||. |||| ..| |||..||.. |. . ..      . | . | |||.|||||||..||.|| ...|.    ...  .| ||.|
ketygeitvsllskeefadlivrklkvskkkee......kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqC

subfamily_PTPN6_pd Subfamily PTPN6 1-186 2.8e-59 195.6 In-house 52-234 (306) alignment
Range on Protein: 1-186
Range on HMM: 52-234/306.0
PENKIKNRYGNIVTYDHTRVVLKgpgGNRDGRSDYINASYLQ-GFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN
|||| |||| ||. .|||||.||    .    ||||||.|..  . |. |.|||.|| .|    |||.||||| . ||||.|  .| .|||| .||||..
penkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee

QPKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT----APWIVHC
. . ||...|. ..... |||..|...|. .       ..  | ..||||..|||.|||.   ||| | ... ..... .     | .|||
ekeeyGkisvtnvseksladYilRelsvskk.....kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhC

0047943 (Phosphotyrosine protein) phosphatases II 1-186 1.6e-58 193.7 In-house 36-212 (273) alignment
Range on Protein: 1-186
Range on HMM: 36-212/273.0
PENKIKNRYGNIVTYDHTRVVLkgpggnRDGRSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
|||| |||| .|. |||.||.|       || ||||||||..|.. ..| .||.||| . ...|||.|||.....|||||| |.| ..|||..|||....
penkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwplegg

--PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLqqqrvgDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHC
  .. ||..|| | . | ..||||||. .|         ..  |.....|.| ||| |||.. . .|.| ... .  ..  .  | .|||
elsltygkftvtllseetkddytvrtleltnlg......tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC

subfamily_PTPRG_pd Subfamily PTPRG 1-186 1.7e-58 193.2 In-house 45-227 (563) alignment
Range on Protein: 1-186
Range on HMM: 45-227/563.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
|||| |||| |||.||..|| |..  |. ... |||||.|..|.    |..||.|||..  .||||.|.|... ..|||.| | | ...||. |||  ..
penkrKnRylnivaydrsRvklsplpgk.kkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.de

PKPYGQYTVSLCKNEAFADYTVRTFLVTV-RLQQQRVgDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. ||. .| | ..| .| |||||. .   .|....   .  . ..|||.| |||.|||.... || | ||     .... | .|||
setygalqvtlieeevlalytvrtlviknlklkkkkq.cdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHc

0045450 (Phosphotyrosine protein) phosphatases II 1-186 1.8e-58 194.1 In-house 53-241 (307) alignment
Range on Protein: 1-186
Range on HMM: 53-241/307.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASYL--------QGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCH
|||| |||| .|. ||||||.|. ..|. .. ||||||||         .|.|  ..|.||.||| . ...|||.|.|.....||||||.|.| ..|||.
penkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekca

KYWPDTNQPKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN--ESRHNTAPWIVHC
.||||..... ||..|| | . |  ..|||||. ||        |..  |.....|.| ||| |||..   .|.| ... .  |.  .  | .|||
qywPdegeeltygnftvtllseehldgytvrtlevtdl.....dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHC

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-186 4.2e-58 191.7 In-house 45-219 (288) alignment
Range on Protein: 1-186
Range on HMM: 45-219/288.0
PENKIKNRYGNIVTYDHTRVVLKGpgGNRDGRSDYINASYLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
..|. |||| ||..||..|| ||.  ..    .|||||||..| ..  |||||.|||.  . .|||..|.... | |||||.|.||.|.||..||||...
avnakknRyrnilpyDekrvklkk..leeeagaDYinasyidg.ekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadk

PKPYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
|| ||. || | ...   |...|..|.          ... . | ||....|||.|||. .. .| ..... . .  .| | ||||
pknyGsvtvtlveskeledfvlrkllle........kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhC

0039614 (Phosphotyrosine protein) phosphatases II 1-186 1.7e-57 190.5 In-house 54-229 (297) alignment
Range on Protein: 1-186
Range on HMM: 54-229/297.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKeKCHKYWPDTNQ
|||| |||| .|. |||.||.||...|  |  ||||||||..|.| ...|.||.||| . ...|||.|||.....|||||| |.| .. ||..|||.. .
penkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg

pkPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrvgDE-GlRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHC
   ||..|| | | |  ..|||||. ||         ..   |.......| ||| |||.... .|.| ... .  ..  .  | .|||
..tygdftvtllkvehldgytvrtlevtn........nges.rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHC

0043336 (Phosphotyrosine protein) phosphatases II 1-186 3.7e-57 189.2 In-house 43-217 (278) alignment
Range on Protein: 1-186
Range on HMM: 43-217/278.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPdtNQ
|||| |||| .|. |||.||.|.  ||  |  ||||||||. |.. ..| .||.||| . ...|||.|||......|||||.| | ...||..|||  ..
penkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..gg

PKPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. ||..|| | | | ..||||||. ||        ||   |....||.. ||| |||   . .|.| |....  ...  | .|||
sltygdftvtllkeehlddytvrtlevtn......lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHC

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-186 7.9e-55 181.1 In-house 46-223 (319) alignment
Range on Protein: 1-186
Range on HMM: 46-223/319.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNq
.||| |||| ||..||.|||||.   |  .  |||||||...|..   .|.||.|.|.|   .|||.|||.|..|..||||.| |  | |..||||..| 
eenkkknryqnilaydrtrvvlseldgveg..sdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen.

PKPYGQYTVSLCKNEAFADYTVRTFLVtvRLQQQRVGDeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR-HNTAPWIVHC
.. ||...| | ..|  .|| .| . .  . ... |     | . ....| |||..||..||..| . |.| .  . ..  | .|||
feeyGrlivtleeeeeledyiirklkl..nkkssevet...RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhC

0045098 (Phosphotyrosine protein) phosphatases II 1-186 1.6e-54 180.5 In-house 31-213 (278) alignment
Range on Protein: 1-186
Range on HMM: 31-213/278.0
PENKIKNRYGNIVTYDHTRVVlkgpggnrdgrsDYINASYLQGFdgtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
..|. |||| .|. |||.||.            |||||||..|.   |||.||.||| .  ..|||.|.|.....||||||.|.|...|||..|||. ..
lgnldknRykdilpydhsrVk............dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.gg

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRVGDegLRFIYQYHFTVWPDKGVPQYA--TAVLRFRKKIINESRH-------------NTAPWIVH
.. ||..|| | . | . |||.||.|||    ..  .    |.....|.. ||| ||| .   . .|.. . | .  ..             .  | .||
sltygdftvtllseevlddytlrtllvtnltveredle..srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

C
|
C

0040439 (Phosphotyrosine protein) phosphatases II 1-186 1.7e-53 177.1 In-house 9-186 (249) alignment
Range on Protein: 1-186
Range on HMM: 9-186/249.0
PENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
|||| |||| .|. |||.||.|.  .|     ||||||||. |.. ... .||.||| . ...|||.|.|.....|||||| | | ..|||..|||. ..
penkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.gg

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHC
.. ||..|| | . | ..||||||. .|        .|   | ......| ||| |||..   .|.| ... .  ..  .  | .|||
sleygdftvtllsvevkddytvrtleltnl......ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHC

0042113 (Phosphotyrosine protein) phosphatases II 1-186 5.9e-53 175.1 In-house 7-183 (245) alignment
Range on Protein: 1-186
Range on HMM: 7-183/245.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
|||| |||| .|. ||||||.|. .||. |  ||||||||  |.. ||| .||.||| . ...|||.|.|......||||| . | ...||..|||. ..
penkdknrysdilpydhtrvklspdggdld..sdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR-HNTAPWIVHC
.. ||..|| | . | ..||||||. ||        ||   |....||.. ||| ||| .   .|.| . . .  . ..  | .|||
sltygdftvtllseehlddytvrtlevtnl......gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHC

0037934 (Phosphotyrosine protein) phosphatases II 1-186 1.3e-51 170.9 In-house 8-185 (243) alignment
Range on Protein: 1-186
Range on HMM: 8-185/243.0
PENKIKNRYGNIVTYDHTRVVLkgpggnrDGrSDYINASYLQGFDgtpkKYIAAQGPVEPSCDD----FWQMVWQERCSVIVMLTGLIEGNKEKCHKYWP
|||. |||| .|..|||.||.|       .| ||||||.. ....    ..|| ||| . ...|    ||.|.|.....|||||| |.| ..|||..|||
penlsknrysdilpydhsrvkl.......eg.sdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dtNQPkPYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqRVG-DEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINE--------SRHNTAPWIVHC
  ..   ||..|| | . | ..||||||.|..      ... |.  |....||.. ||| |||.  . .|.| .....          ...  | .|||
..gev.tygdftvtllseehlddytvrtllle......nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-186 2.2e-51 169.4 In-house 44-223 (290) alignment
Range on Protein: 1-186
Range on HMM: 44-223/290.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
..|| .||. ||| ||  |..|.  .|..|   .||||.|..|.    |.|||.||||.    |||...|||....|||||  || .|.||..||||...
ssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdt

PKpYGQYTVSLCKNEAFADYTVRTFLVTVRLQQqrvgdEGLRFIYQYHFTVWPDKG-VPQYATAVLRFRKKIINESRHNTAPWIVHC
 . ||.... | ..|.. .|. |.. |. . ..     .  . . ||..| |...| |....| .| ... . .. ..   . .|||
ka.ygefsikllneetlneyierklevknknsa.....gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHC

subfamily_PTPN3_pd Subfamily PTPN3 1-186 7.2e-50 164.5 In-house 39-215 (280) alignment
Range on Protein: 1-186
Range on HMM: 39-215/280.0
PENKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASYLQ-GFDG--TPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPD
|||  |||| .|..||.||| ||      ....|||||.|..   ..  . ..|||.|||.. .. |||||||....|.||||| |.|  . |||.|||.
penlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

TNQPKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRvgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
|..   ||...| . |...   | .| .... . ....      | | |  .. |||.|||. .. .|.| ... .  . .. | .|||
tedeleygefsvkcekedetksyvlrelvlkdketkee......rkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-186 3.2e-48 159.7 In-house 59-231 (319) alignment
Range on Protein: 1-186
Range on HMM: 59-231/319.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTgliegnKEKCHKYWPDTNQ
..|| |||..||...|...| |.   |     |||||||...|.   ..|||||||| . . .|||.|.|. .|| ||.||      |.|| .|||   .
dqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

PKpYGQYTVSLCKNEAFADYTVRTFLVTvrlqqQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKK--IINESRHNTAPWIVHC
 | .... |..   |  |.|.|| . ..     .    .. | | |.||  |||.|||.|.. ..|. ||   ...  .. |. .|||
ik.eerfkvkvdsveetaeyvvrdiels.....edgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhc

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-186 1.2e-47 157.8 In-house 23-195 (284) alignment
Range on Protein: 1-186
Range on HMM: 23-195/284.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTgliegnKEKCHKYWPDTNQ
..|| |||.|.|...|...| |.   |.    |||||||...|.   ..||||.||| . . .|||.|.|. .|| ||.||      |.|| .|||   .
dqnkdknrighilafdknvvklerliGee..fsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

PKpYGQYTVSLCKNEAFADYTVRTFLVTvrlqqQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKK--IINESRHNTAPWIVHC
 | .... |..   |  ..|.|| . ..     .    .. | | |.||  |||.|||.|.. ..|. ||   ...  .. |. .|||
ik.eerfkvkvdsveeseeyvvrdiels.....edgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

subfamily_PTPN1_pd Subfamily PTPN1 1-186 4.6e-42 138.7 In-house 30-208 (290) alignment
Range on Protein: 1-186
Range on HMM: 30-208/290.0
PENKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASYLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
|||. .||| ..  |||.|..|.      ..  |||||| .. ..   ..|| .|||.   .| ||||||....  .|||  ..| .. ||..|||  ..
penrnlnryrdvspydhsrikle......radndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

P----KPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINES--RHNTAPWIVHC
         ...| | ..|    ||||.. ..       .  .  | |...|.| ||| |||.  .| |.|  |. .     ..  | ..||
ekellledtklkvkliseerksyytvrllelen......lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihc

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-186 1.9e-40 134.0 In-house 46-228 (325) alignment
Range on Protein: 1-186
Range on HMM: 46-228/325.0
PENKIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMV--WQerCSVIVMLTgLIEGNKEKCHKYWPDT
|||| |||. |.|..|..||||.  .   |. |||||||||. . .  . ..||| |   . .|.|..|  |.  |||.|.|   ....|..| .|||. 
penkaknrfknvvaldksrvvletkk..ddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr..csvvvvln.eldlgkdrcavywpke

-NQPKPYGQYTVSLCKNEAFADYTVRTFLVtvrlQQQRVGDegLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN--E----SRHNTAPWIVHC
  . | .|   |.|   | ..||  | . |    .| . |.   | . |...  |.| ||... .... . . . .  |      . ..| .|||
mgksktfGglevklrtieeisdyvhrvldv....kqvkkGe..trsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

subfamily_PTPN14_pd Subfamily PTPN14 1-186 3.6e-38 126.3 In-house 47-236 (300) alignment
Range on Protein: 1-186
Range on HMM: 47-236/300.0
PENKIKNRYGNIVTYDHTRVVLKGpggNRDGRSDYINASYLQGF-DGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-
|||. |||. ... |...|| |.    ... ...||||| ..    |. ..||.||||.|  . |||||||..  ..|||||  .|. |||..||.|.. 
penaeknrfkdvlPyednrvelsp...tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkle

--NQPKPYGQYTVSlcknEAFADYTVRtfLVTVRLQQQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR---------HNTAPWIVHC
  ..   .|.. |.    . | . . .  ..|  |. . .  .  | ..   .| |||.|||.  .  | . ...    |         ..  | .|||
skkktvefgkfkvt....tkfsedsds..vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1-186 1.4e-29 97.6 In-house 35-207 (281) alignment
Range on Protein: 1-186
Range on HMM: 35-207/281.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDgRSDYINASYLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
| |. |||| ||   | .|| ||    |..  .||| | |..      . || .||| . .  |||.|.|||  . ||||  ..| |.||| .|.|   .
pvnnkknrylnipcldisrvqlkvkmpnkn.stdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

PkpYGQYTV-SLckneAFADYTVRTFLVTVRLQQQRVGDegLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHC
     |.   |.    .. | ||   ||| ||.    |.   |.| .. .  |||  ||. .  .|.  .||    |  ..| ..||
c..clqfdklsv....syedstvnkslvttrlnlsyege..trlithwlwkewpdwqvpessevmlkilrki....rarstppvihc

0049772 (Phosphotyrosine protein) phosphatases II 1-186 1.1e-26 89.8 In-house 44-219 (314) alignment
Range on Protein: 1-186
Range on HMM: 44-219/314.0
PENKIKNRYGNIVTYDhTRVVLkgPGGNRDGrSDYINASYLQGFdgtpKKYIAAQGPVEPSCDDF----------WQMV--WQERCSVIVM---------
..|. |||| .|. .| .||.|  || . .| ||||||||. ||    .|.||.||| |  ..||          |.||  .. .. .|||         
flnrdknryldilpad.nrvil..pglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTGLIEGNKEKCHKYWPDTNqpkpygqytvslckneafadytvrtflvtvrlqqQRV--GDEGLRFIYQYHFTVWPDKGVPqYATAVL
            |..| ... | . ..... .                                  ...  ..   | ...|. . .|| ..|     ..
lsrLdaAlgKtpllildgngneptaadlellk..................................eelydpelferlgikylripvpDgsap.lledfd

RFRKKIINEsrHNTAPWIVHC
.| . | .   ..  | .|||
eflefieea..dkggpvlvHC

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1-117 4.7e-13 43.3 In-house 94-201 (244) alignment
Range on Protein: 1-117
Range on HMM: 94-201/244.0
PENKIKNRYGNIVTYDHTRVVL-KGPGGNrdgrsDYINASYLqGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLtglieGNKEKCHKYWPDTN
|.|  ||| |  . .|  || | ||  ||      |||||.. |  |   .|| .| |.  .  |||.|. .    |.|.|     |  |.  .||||..
pnnswknregaglpfdfnrvplskgsmgn.....tyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvl.....gsveeedeywpdse

QPKPYG-QYTVSLCKNEAF
  . |  . ||.|   . |
plewyeeditvtltdrdef

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1-46 4.6e-10 33.4 In-house 45-88 (440) alignment
Range on Protein: 1-46
Range on HMM: 45-88/440.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDG
|.||.|||| ||..|||.||.|.   |  |  ||||||||..| . 
pnnkvknryrnilaydhsrvmleevkgvpd..sdyinasyingies

subfamily_PTPRB_pd Subfamily PTPRB 2-186 7.4e-60 197.5 In-house 50-225 (293) alignment
Range on Protein: 2-186
Range on HMM: 50-225/293.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP
.|. |||| ||..|||.|| |.    . .  ||||||.|..|.  .|...||.|||.  . ||||.|||....|.||||| |.|. |.||..|||....|
vnraknrytnilpydhsrvkLaal..kdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeep

KPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrvgDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINES--RHNTAPWIVHC
  ||. .|.| ..|   |...|.....         ..  | . ||||| ||| |||. ....|.| ... ..    ....| .|||
vlyGdikvtlvaeeeledwvirelkiek........ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhC

DSPc_SM00195 2-186 4.5e-58 192.0 In-house 25-202 (263) alignment
Range on Protein: 2-186
Range on HMM: 25-202/263.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASYLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-NQ
.|| |||| ||. |||||| || . ..    ||||||.|..|    .|||||.||| .  ..|||.|||.|....|||||   | .||||..|||.. ..
knksknRyknilpydhtrVklkkeekk..egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesgg

PKPYGQYTVSLCKNEAFA-DYTVRTFLVTVRLQqqrvgdEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. .|...| | ..|    ....||. .|   .      |  |...||... |||.|||. .. ||.. ... ........| .|||
ketfgkisvklvevekkkdeiilrtleltkegk......eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC

PTPc_SM00194 2-186 4.5e-58 192.0 In-house 25-202 (263) alignment
Range on Protein: 2-186
Range on HMM: 25-202/263.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASYLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-NQ
.|| |||| ||. |||||| || . ..    ||||||.|..|    .|||||.||| .  ..|||.|||.|....|||||   | .||||..|||.. ..
knksknRyknilpydhtrVklkkeekk..egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesgg

PKPYGQYTVSLCKNEAFA-DYTVRTFLVTVRLQqqrvgdEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. .|...| | ..|    ....||. .|   .      |  |...||... |||.|||. .. ||.. ... ........| .|||
ketfgkisvklvevekkkdeiilrtleltkegk......eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-186 1.2e-57 190.2 In-house 40-215 (281) alignment
Range on Protein: 2-186
Range on HMM: 40-215/281.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP
||. |||| ||| ||.|||...    ...  .|||||....|..| .|.|||.||||  |...||||||... |.|||.|  ||..| |||.|||| |. 
envlknrYsnivaYDatrvkvtpn..eenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnse

KPYGQYTVSLCKNEAFADYTVRTFLVtvrlqQQRVGDEglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT-APWIVHC
  ||..||.  ..|. | |  |.| .     ... |..  | . | ..| |||.|||. ....| |||.. . ....| || ..||
lkygdvtvkstaeeekatyierkfkl.....eresget..reveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihC

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-186 2.4e-56 186.1 In-house 45-220 (318) alignment
Range on Protein: 2-186
Range on HMM: 45-220/318.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQP
 || |||| ||..|||||| |.   |.    ||||||.|..|.    |.|||||.|.   ..|||.|||.  ..|||||| . |  |.|.|.|||. ...
vnkaknryanilaydhtrvkLqmlegee..gsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kgs

KPYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINES-RHNTAPWIVHC
. ||. .| | ..  ..||..|.| ||      | . |  | . |||.| |||.|||. .. .| . ... .   .... | .|||
rsygklvvelkeevelsdyvlrefkvt......rteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC

subfamily_Ptp69D_pd Subfamily Ptp69D 2-186 7.8e-55 181.2 In-house 47-226 (307) alignment
Range on Protein: 2-186
Range on HMM: 47-226/307.0
ENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTnQP
||..|||| .|...|.|||.||   |  .  |||||||...|.. . ||.||||.|||   .|||.|...    .||||. | | |..||.||||.  . 
enalknRyedikafDktRvkLkking..kedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.de

KPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
. ||.  | | ..|   ||. |.. |.   ..     |  | . |||.| |.|  ||. |...|.. ... .  ..| .| .|||
vqygdilvklvseekhsdyiiReldvskkkees.gevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhC

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-186 5.5e-54 178.2 In-house 48-219 (315) alignment
Range on Protein: 2-186
Range on HMM: 48-219/315.0
ENKIKNRYGNIVTYDHTRVVLkgPGGNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTnqP
||| |||| ||..||..|| |  |  . |  |||.||....|..  ...|||||||   | .|||..|..| .. |||||.|.||.|.|. |||||    
enkqknryiniiaydksrvql..pllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..k

KPYGQYTVSLCKNEAFADYTVRTFlvtvrlqqQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
  ||..||.. ..| . .|||||.          | .. .| ..|.|.| ||| |||.|..... . ...      . .. .|||
viyGkitvtrkseevnteytvrtl........svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhc

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-186 2.4e-53 176.3 In-house 45-223 (305) alignment
Range on Protein: 2-186
Range on HMM: 45-223/305.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP
.|| |||. .|...|. |. |.    .    ||||||||..|...  ||||.||||..   .|||.....|. |.|||||.|.||.|.||..|||.. . 
ankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskte

-KPYGQYTVSLCKNEAFADYTVRTFLVTVRLQqqrvgDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT-APWIVHC
 | .|...| |  .....||. | . .... .     |.  | . ||..| |||.||||.||..|.. |.. .. ...   | .|||
kkefgefsvelksektasdyieRklkisiede.....dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhC

subfamily_PTPRA_pd Subfamily PTPRA 2-186 5.6e-53 175.0 In-house 57-235 (330) alignment
Range on Protein: 2-186
Range on HMM: 57-235/330.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQp
||| |||. ||. ||..||.|    |. .  |||||||...|.    .|.|||||| | . .|||.|.|. . . ||||| | | ..|||..||||    
enkeknrvvnilPydfsrvilsvkeGvee..sdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.

KPYGQYTVSLCKNEAFADYTVRTFLVTvRLQQqRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
  ||. .|.. ...   ||||| |||. .| .    ..  | . |.||| ||| |||  .  .|.. ||. .  . .. | .|||
vtyGnirvevedetvlvdytvrkflvq.qlpd.atrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhc

subfamily_PTPRK_pd Subfamily PTPRK 2-186 4e-50 165.4 In-house 42-217 (314) alignment
Range on Protein: 2-186
Range on HMM: 42-217/314.0
ENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP
||. |||.|.|..||..||.|.   |  |  ||||||... ..   |...|..|||..    |||..|..|.|. ||||| |.|  . || ||||.  . 
enreknrsgdilaydrsrvflitidg..dpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

kpYGQYTVSLCKNEAFADYTVRTFLVTVrlqqQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
  ||.  | | . |. |.. ||.| |.        | |. | . |..|. ||| .||..||..|.. ... . . ..  . .|||
..ygdikvelvetellaelvvrifrvek....largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhC

subfamily_PTPN12_pd Subfamily PTPN12 2-186 5.8e-50 164.8 In-house 39-214 (290) alignment
Range on Protein: 2-186
Range on HMM: 39-214/290.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP
||. |||| .|. ||..||.|.   ..    ||||||....| .| ...|||||||.    ||||.|.|. . ...||.  ..| .| ||..|||.... 
envkknrykDilPydksrvelskieeee..gsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee

KP-YGQYTVSLCKNEAFA-DYTVRTFLVTVRlqqqrvgdEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.  .|...|.| ...|.  |...||. |...        .  | .||.|.| |||.|||. |. .|.. ... .  ... || .|||
elefgefevtleeekavdddflirtLkveaq........kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhC

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-186 2.2e-49 163.0 In-house 46-218 (287) alignment
Range on Protein: 2-186
Range on HMM: 46-218/287.0
ENKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQp
.|| |||. .|. .|  ||.||      . . |||||....|.    |..|.|..|.     .||....... ..||||. . | ..|.|..|||...  
qnkdknRltqilvpdnyrvllk......gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.

KPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRVgdeglRFIYQYHFTVWPDKG-VPQYATAVLRFRKKIINESRHNTAPWIVHC
  .|.|...| ..|  |.|..|.. |. . ...       . . ||..| |...| |....| .| . ... .. ..  .. .|||
vvlGeyniellneevnagyierklevknknkagdk.....qqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhC

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-186 2.4e-48 159.6 In-house 43-217 (315) alignment
Range on Protein: 2-186
Range on HMM: 43-217/315.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPD-TNQ
.|  ||||.||. .|..||.|.    . .  ||||||||....|   | |||.||| . | ||||.||.||. . |||.| . ||.| || .||||   .
infkknryknilPldsarvklevi..ddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

PKPYGQYTVSLCKNEAFADYTVRTFlVTvrlqqqRVGDEgLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
   .|.. |.| . || .| ..| . ||      | ..|  | . |..|| ||||||.. ....|.. |..  . .... . .|||
svefGsikvellsleadtdgvarkl.vt......rksee.srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhc

subfamily_PTPN9_pd Subfamily PTPN9 2-173 1.2e-45 150.8 In-house 41-204 (297) alignment
Range on Protein: 2-173
Range on HMM: 41-204/297.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWP-DTNQ
 |  |||| ... ||.|||||.    . |  ||||||....|.   .| .||.|||..  ..|||.|||.... |||| | ..|  . || .||| ....
anleknrytdvlcydetrvvlakv..dedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

PKPYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN
 . .|...||  . |   ||.||.. ..      .| .|  | .  . |. ||| |||. |...| ...|. .
saefgdlsvsnveveeeedykvrvleik......nvkteesrkvthfqflsWPdyGvPssaaslldvlekvre

subfamily_PTPRN_pd Subfamily PTPRN 2-186 3.8e-43 142.3 In-house 55-231 (297) alignment
Range on Protein: 2-186
Range on HMM: 55-231/297.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQp
.|  |||. ....|||.|| ||    . . .||||||| .   |     |||.|||.  .  |||||||.. . |||.|| | | . ..|..||||. . 
knvkknrskavlpydhsrvklkee..asaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGs.

KPYGQYTVSLCKNEAFA-DYTVRTFLVTvRLQQQRVgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
. |. | | |  .  .. || ||.| .   ||...      | . |.||  ||..|||  | ..| ||.|.    |  ..| .|||
evyhiyevhlvsehiwcddylvrsfylk.nlqtset.....rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhc

subfamily_PTPN13_pd Subfamily PTPN13 2-186 4.1e-40 132.8 In-house 36-209 (273) alignment
Range on Protein: 2-186
Range on HMM: 36-209/273.0
ENKIKNRYGNIVTYDHTRVVLKGPGGnrdgrsdYINASYLQGFDG-TPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
||| |||| |.. ||.||| |.. ||       |||||...   |    .|||.|||.  ...|||||||. ...||.|.|   |..| |||.|||....
enkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPeskn

P--KPYGQYTVSLCKNEAFADYTVRTFLVTvRLQQQRVgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRhNTAPWIVHC
   | .....|.| | .   ...||.. |.  .. ...     | . . .|. ||| |||. |. .|.| ... .  . ...| .|||
kklkvsnrlevellkvqkldgfvvralavk.dsesges.....revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhc

subfamily_CG7180_pd Subfamily CG7180 2-186 8.6e-38 124.6 In-house 41-230 (296) alignment
Range on Protein: 2-186
Range on HMM: 41-230/296.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKeKCHKYWPDTNqP
||. |||. ..| ||..||||.  .|. .  ||||||.| ..|   .|.||  ..|.. . |.||..|..| .| .|.||   . .| ....||| .   
enreknrdvkvvPyDynRvvLekldGeek..sdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.k

KPYGQYTVSLCKNEAFADYTVRTFLVTVR----LQQQRVGDEGLRFIYQYHFTVWPD-KGVPQYATAVLRFRKKIIN---ES--RHNTAPWIVHC
. ||.  | . ... .|. . ||| .| .     .|..  .   | . ....|.|.  . ||  ..|.. .|...     .   . ...| .|..
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-186 7.9e-37 121.6 In-house 39-233 (301) alignment
Range on Protein: 2-186
Range on HMM: 39-233/301.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN-Q
|||  ||. ||..||. |..||        . .||||||..|.    ||.||||||..    |||...|||. . |||.|.| || |.||..|||... .
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQ--------R-VGDEGLRFIYQYHFTVWPDKGV-PQYATAVLRFRKKIINESRHNTAPWIVHC
 . .|. || | .. .. |...| . |...   .        .   |   . . |.. | ||. || ....| .    . |. . . . .| .|||
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHC

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-186 8.7e-37 121.5 In-house 32-206 (283) alignment
Range on Protein: 2-186
Range on HMM: 32-206/283.0
ENKIKNRYGNIVTYDHTRVVLKGPGGnrdgrsDYINASYLQ--GFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN
||| |||. .||..|  || ||          |||||...     .   ||||.||.|..    |||.||..|. . ||||| | |....|| .|||   
enkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

QpKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqRVGDEGLRfIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
  . ||..||.| |. .   .... .|. |         . |  .  | .  | . |      ....| | | .  ... .| .|||
s.edyGeftvtlrkettsnsfiikelllrvn....ssakstll.lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhC

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2-186 1.3e-36 120.8 In-house 44-176 (392) alignment
Range on Protein: 2-186
Range on HMM: 44-176/392.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNkekchkywpdtnqp
 |. ||||.||. || .||.|.    .    |||.||||...||   | |||.|||   | ||||.||.||. . |.|.| | ||.              
inlkknryknilpydsarvklevi..ddipdsdylnasyipsfdn.ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..............

kpygqytvslckneafadytvrtflvtvrlqqqrVGDEgLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
                                   ||.  | . |.||| ||||.||......|.| |..  .  . | | |.||
..................................kgdd.artvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihc

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-186 1.1e-74 245.6 In-house 8-181 (239) alignment
Range on Protein: 3-186
Range on HMM: 8-181/239.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQpk
|| |||| |||||||.||||.    . | .|||||||||. .||.|| |||.|| ||.|. |||.|.||||  ||||||||||| |.|||.||||.    
nkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

PYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
 | .  |.| | | |||| .|||...      .||.   |..||||||||||||||||||||| .|.|| ..|   . ||..||
kycnlrvtlrktevfadyiirtfvms......qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihc

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3-186 1.1e-74 245.6 In-house 7-180 (239) alignment
Range on Protein: 3-186
Range on HMM: 7-180/239.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQpk
|| |||| |||||||.||||.    . | .|||||||||. .||.|| |||.|| ||.|. |||.|.||||  ||||||||||| |.|||.||||.    
nkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

PYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
 | .  |.| | | |||| .|||...      .||.   |..||||||||||||||||||||| .|.|| ..|   . ||..||
kycnlrvtlrktevfadyiirtfvms......qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihc

Y_phosphatase Protein-tyrosine phosphatase 3-186 1.4e-57 190.2 Pfam-A 1-177 (235) alignment
Range on Protein: 3-186
Range on HMM: 1-177/235.0
NKIKNRYGNIVTYDHTRVVLkgpgGNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWP-DTNQP
|| |||| .|. ||.||| |     ...|.||||||.|..|.. ..||.||.|||.. ...|||.|||||...|||||| | | ..|||..||| .....
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

KPYGQYTVSLC-KNE-AFADYTVRTFLVTVRLQQQrvgdeGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
. ||...| |  |.. . ..||.|.. .. . ...       | ..|.|.| |||.|||. ....|.. .|. ........| .|||
ltygdikvelkekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhC

Y_phosphatase Protein-tyrosine phosphatase 3-186 1.4e-57 190.2 In-house 1-177 (235) alignment
Range on Protein: 3-186
Range on HMM: 1-177/235.0
NKIKNRYGNIVTYDHTRVVLkgpgGNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWP-DTNQP
|| |||| .|. ||.||| |     ...|.||||||.|..|.. ..||.||.|||.. ...|||.|||||...|||||| | | ..|||..||| .....
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

KPYGQYTVSLC-KNE-AFADYTVRTFLVTVRLQQQrvgdeGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
. ||...| |  |.. . ..||.|.. .. . ...       | ..|.|.| |||.|||. ....|.. .|. ........| .|||
ltygdikvelkekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhC

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-186 4.7e-50 165.1 In-house 43-216 (515) alignment
Range on Protein: 3-186
Range on HMM: 43-216/515.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPD-TNQP
|  ||||.||. || .|| |.    | .  |||.||||...||   | |||.||| . | ||||..|.||. . |.|.| | ||.| || |||||   . 
nfkknryknilPydsvrvklevi..ndnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

KPYGQYTVSLCKNEAFADYTVRTFLVTvRlqqqrvGDEgLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
  .|.. |.|   || .. . |.. |. .      ||.  | . |.||| |||||||. ....|.. |..  .  . | | |.||
vkfGsikvelvsleactggikrkltvl.k......gdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihc

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3-186 4.4e-47 155.5 In-house 28-208 (274) alignment
Range on Protein: 3-186
Range on HMM: 28-208/274.0
NKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP-
.. |||| .|.  ...||.|.   .. |  |.|||| |..|.|.. | |.|.|||.    .|||.|..||...|||||| | | |..||..|.||...  
sqtknryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

--KPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRvgdeglrfIYQYHFTVWPDKGVPQYATAVLRFRKKIIN---ESRHNTAPWIVHC
  . ||.  .   |     ||.||....    ....        .. | .| |||. .|. |...|.. ... .   |. ...|| .|||
iserygdveikvekiverndysvrklvlkylerers........vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhC

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3-186 4.7e-41 135.6 In-house 20-204 (270) alignment
Range on Protein: 3-186
Range on HMM: 20-204/270.0
NKIKNRYGNIVTYDHTRVVLkgPGGNRDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtnQPK
.|  ||| .|.   .|||.|  .  . | .. |||| |..|||| .||||||.||.. .  .||.|.|.|. . |||.||| | ...|| .|||   .||
gkklnRyadiLPsPatRvrl..eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa..epk

PYGQYTVSLCKNEAFADYTVRtFLVTVRLQQQRVGDEgLRFIyQYHFTVWPDKGVPQYAT------AVLRFRKKI---INESRHNTaPWIVHC
   ...    |  | ..   . . .. ||. .. |.|  | .  .... |||.|||. .        .|.  ...    .| .... |..|||
ekvkledgkikvlalseekee.gyiltrlrleekgee.rrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHc

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 3-186 5.5e-32 106.0 In-house 41-216 (307) alignment
Range on Protein: 3-186
Range on HMM: 41-216/307.0
NKIKNRYGNIVTYDHTRVVLKGPGGNrdgrSDYINASYLqGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-NQP
|  |||| ..   |..|.|.| .|      |||| | || |    |||.|.|||| | .  .|| |. ||.   ..||  .||  | ||..|||    | 
ntdknryqdvkcqdkgrivvkfdgla....sdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

KPYGQYTVSLCKNEA-FADYTVRTFLVTVRLQQQrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLrfrkKIINESRHNTAPWIVHC
. .|. . ... ..      .    |. |   .  .  .. | | .. .. |||.||||   . .     ...  | .| | .|||
lvfgeapntisvanlgakklapdedlinvttlkv.dwaqksrtiqhlqwenwpdrgvpqinltai....nlleavrydtnpvvvhc

subfamily_ptpA1_pd Subfamily ptpA1 3-186 2.7e-31 103.8 In-house 47-236 (418) alignment
Range on Protein: 3-186
Range on HMM: 47-236/418.0
NKIKNRYGNIVTYDHTRVVLKGPGgNRDGrSDYINASYLQGfdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPK
|  |||| ||.  .|||| ||    ...| |||||| |..|    ||..|..|||.  .  |||.|||..|| .||||.   |  . || .|||.    .
ntsknrytnilpvnhtrvqlkkiq.dkeg.sdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

pygQYTVSLCKNEAFADYTVRTFLVTVR------LQQQRVGDEG-LRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN------ESRHNTAPWIVHC
   |...    || |  |.|    |          .. |.  ||  | | ||..  |||. .|...  . .. . | |       |     | ||||
...qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

0041856 (Phosphotyrosine protein) phosphatases II 3-186 3.6e-28 93.8 In-house 1-116 (182) alignment
Range on Protein: 3-186
Range on HMM: 1-116/182.0
NKIKNRYGNIVTYDHTRvvlkgpggnrdgRSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTgliegnkekCHKYWPdtnqpk
|. |||| .|. |||.|             .|||||... |   . . .||.|||   .. ||..|........||.||         .. |||      
nldknrysdilpydhsr............dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp......

pygqytvslckneafadytvrtflvtvrlqqqrvgDEGLRFIYQYHFTVWPDKGVPQyATAVLRFRKKIINesrhNTAPWIVHC
                                   ..  | ..||... ||| |||     .|.| .....    .  | .|||
...................................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHC

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 3-186 2.8e-26 87.0 In-house 48-226 (305) alignment
Range on Protein: 3-186
Range on HMM: 48-226/305.0
NKIKNRYGNIVTYDHTRVVLKGPGGnrdgrSDYINASYLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPK
.. |||| ..   |. || |.||        .|| | |.      ||..| .| |.| .| ||| | .|..   | ||  |.|   .||..|..  ....
eagknrykdvgcldnnrvklegpwp.....heyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

P----YGQYTVslCKNEAFADYTVRTF----LVTVRLQQQRVGDEgLRFIYQYHFTVWPDKGVPQYATAVLRfrkkIINESRHNTAPWIVHC
      ||  .   | |. . .  |.     .    |  .  | .  | . .||.  |||.|||   .|.|     .....|    | .|||
lefeekgqkis..vkfessvtlkfrkdakakvtetvlviegpgek.arkvthyhwidwpdrgvpaadlaile....llekarpskgpivvhc

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 3-186 2.2e-20 67.9 In-house 43-211 (288) alignment
Range on Protein: 3-186
Range on HMM: 43-211/288.0
NKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASYLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ-P
|  ..|| |.   | ||| |.      |    ||.|  .      ... | || |..   . .|.|. ..    ||||. |.|  |||  .|.|      
nptrdryenlprcditrvkls......ddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

KPYGQYtVSLCKNEAfadYTVRTFLVTVRLQQQRVGDEGLrFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHC
  .|..  .  |..      .   ..   |. ...|.|   .. . |.  |.|.|||.   . ||. . .    .  . | .||.
arigrl.ctvvkkkr...adidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevl....kslqkPivvhs

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 3-128 8.6e-20 65.8 In-house 33-149 (267) alignment
Range on Protein: 3-128
Range on HMM: 33-149/267.0
NKIKNRYGNIVTYDHTRVVLkgpggnRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHkyWPDTNQPK
|. .||. . . ||.|||.|      |.   .||||||..|.  | ...|. |.|.. .  ||.... .....|||.||   ..|  . .   |   | |
nqernrlddnlpyddtrvil......rtkeeeyinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfw..PPkmgqak

PYGQYTVSLCKNEAFADYTVRTFLVT
 | . ||  . ..   || . |. . 
kyqdltvehslekeendyqiitlelk

subfamily_egg_pd Subfamily egg 3-120 1.2e-19 65.1 In-house 40-155 (307) alignment
Range on Protein: 3-120
Range on HMM: 40-155/307.0
NKIKNRYGNIVTYDHTRVVLKGPGGNRDGrsDYINASYLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGnkEKCHKYWPDTN-QP
|. | |   .   | .|| |. . |   .  |.| | ...| .    ..| || |.  . ||||.||.||..  |||||   |   |.|. ||| .. ..
nlekarskrvhckdssrvklelrrGqyld..dfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

KPY--GQYTVSLCKNEAFADY
  .  | . .   | .  || 
lvtvpGslrienlkvdskadp

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 3-161 3.6e-10 33.9 In-house 47-190 (303) alignment
Range on Protein: 3-161
Range on HMM: 47-190/303.0
NKIKNRYGNIVTYDHTRVVLKgpggnrDgrSDYINASYLQgFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPK
|  |||. ...  ||..| |       |  | || ||||. .| . || | .| |.  .. |||||. ...  ....|    | .|   .  .|  ..  
nmdknrfvdvicldhskvkls......d..ssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

PYGQYTVslcKNEAFADYTVRTFLVtVRLQQQRVGDEgLRFIYQYHFTVWPDKGVPQYA
 . . ..   .   |    .    | ...     ||    |.. .|.  || . .|  .
kfeersi...rvgefkrvelgdgwv.lkvlsvsngdy.ksflhvhhykawphnsipsdg

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 3-174 9.3e-10 32.4 In-house 51-213 (302) alignment
Range on Protein: 3-174
Range on HMM: 51-213/302.0
NKIKNRYGNIVTYDHTRVVLKGpggnrdGRSDYINASYLQGFDGTpKKYIAAQGPVEPSC---DDFWQMVWQERCSVIVMLTGLIEGNKeKCHKYWP-DT
|  ||.  ..  .|...| |..         .|.||| ..  . | .. | || |.  |    ..||.||.||..  .|.| |  | .|   ....|  .
nlkknqsedvpildsnlvklea......epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

NQPKPYGQYTVSLCKNEAFADYTvRTFLVTVrlQQQRVGDEGLRFIyqYHFTVWPDKGVPQYATAVLRFRKKIINE
.. | ||.  |   | |   . .   . . |    . . .  |  .  |..| |..| ||.  ... .  .|. ..
gdykeygkmfvNnrkVekaeeek.tryviEv..lPegcsnsvlanv..yvltnWkqkkvpvkyaeliktaakvfak

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3-56 7.3e-09 29.7 In-house 48-95 (95) alignment
Range on Protein: 3-56
Range on HMM: 48-95/95.0
NKIKNRYGNIVTYDHTRVVLKgpgGNRDgrSDYINASYLQGFDGtPKKYIAAQG
|  |||. ||. || |||||     .||  |||||| ...|.    . ||||||
nipknrflnifpydatrvvlt...tkrd..sdyinacfvdgyar.kncyiaaqg

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 3-164 1.8e-08 27.4 In-house 26-160 (169) alignment
Range on Protein: 3-164
Range on HMM: 26-160/169.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINAsylqgfdgtpkkyiaaqgpvepscddfwQMVWQERCSVIVMLtglieGNKEKCHKYWPDTN--Q
|. |||    ..  |||| |.      |  ||||||                            .|.|.   ||||.|     |. .    .||. .  |
netknrpagplapshtrvklqrv..medlgsdyina............................rmiwetnasvivvl.....Gdtddknnfwpekedyq

PKPY---G-QYTVSLC-KNEAFA-DYTVRTFLVTVRLQQQRVGDEGLRFIYQYHFTVWPDKGVPQYATAV
 .|    |  || ||  . . .  . .    |. | |  ..  |.  . .  .|...||..||||    |
lhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhv

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 3-164 2.8e-08 26.9 In-house 27-161 (169) alignment
Range on Protein: 3-164
Range on HMM: 27-161/169.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINAsylqgfdgtpkkyiaaqgpvepscddfwQMVWQERCSVIVMLtglieGNKEKCHKYWPDTN--Q
|. |||    ..  |||| |.      |  ||||||                            .|.|.   ||||.|     |. .    .||. .  |
netknrpagplapshtrvklqrv..medlgsdyina............................rmiwetnasvivvl.....gdtddknnfwpekedyq

PKPY---G-QYTVSLC-KNEAFADYTVR-TFLVTVRLQQQRVGDEGLRFIYQYHFTVWPDKGVPQYATAV
 .|    |  || ||  . . .   |     |. | .  ..  |.    .  .|...||..||||    |
lhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhv

subfamily_PTPN23_pd Subfamily PTPN23 4-186 1.5e-44 147.0 In-house 44-219 (288) alignment
Range on Protein: 4-186
Range on HMM: 44-219/288.0
KIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPD-TNQPK
  |||. .|. |||.||.|.      ... ||||||....   .  ..||.|.| ...  |||.||.... ||||||.   | .|.|...|||  .....
seknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

PYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQrVgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN----ESRHNTAPWIVHC
 .|...|.| ...    .  |.. .... ... |     . .   ..| ||. |||.    .|.| ... .    . |.  .| .|||
kfgdlsvtlksvretethvervlkletldada.v.....ksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4-186 1.7e-40 134.0 In-house 49-224 (297) alignment
Range on Protein: 4-186
Range on HMM: 49-224/297.0
K---IKNRYGNIVTYDHTRVVLKGpgGNRDGRSDYINASYLQGFDGtpkKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKeKCHKYWPDTNQ
|    |.|| ||. ||  || |.    | |  |||.|||...|.     ..|. | | . . .|||.||..|. |.||||. . |..| || .||.|.  
kvnfeksRYkniLPydssRvkLai..vnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

pKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRvgdeglRFIYQYHFTVWPDKGVPQ--YATAVLRFRKKIINESRHNTA-PWIVHC
 ...|. .| |   .    .  |.. ||    ..|      |.. ||.|. |||| |..   |...| . . . ..  .|.  | .|||
.ttfGdvsvvllsvsereGfikrelevtkgkakar......rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhc

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4-186 6.7e-40 131.9 In-house 49-219 (439) alignment
Range on Protein: 4-186
Range on HMM: 49-219/439.0
KIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKekchkYWPDTNQpKP
. |||| .....|||||.|.   |     | |||| |..|.  ..| |||.||| . ..||||..|...... ||||| |.|  |     |||  ..   
qtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.vc

YGQYTVSLCKNEAFADYTVRTFLVTvrlqQQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKI-INESRHNTAPWIVHC
||. .|   .|  . .|..| | |     ..|   |  | . |.|.. |||| ||  |. || | . |   . .... | .|||
ygdiavrvdrnielpnyvirgfkvf....nerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhc

subfamily_CG42327_pd Subfamily CG42327 4-166 3e-29 96.7 In-house 29-185 (319) alignment
Range on Protein: 4-166
Range on HMM: 29-185/319.0
KIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN---Q
| |.|. |.|   .|||||.  |   | .. |..|||..|.| .|  ||||| . | |  |||..||. .  ||| || | |   ..| .|.|  .   .
kdksrvinvvPlPetrvvlqrig..dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

PKPYGQYTVSLCKNEAFADYTVRTFLVtvrlqqQRVGDEGLRFIYQYHFtVWPDKGVPQYATAVLR
 . ||.. |.| ..|.   | . |.|.      .|| .|  | .  | .  |.. .||   .|.. 
tslyGdilvtlkgrevkdryaistlll......krvdkeesrelthywy.kwleaevPaeeaalia

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 4-186 1.1e-22 75.0 In-house 53-230 (310) alignment
Range on Protein: 4-186
Range on HMM: 53-230/310.0
KIKNRYGNIVTYDHTRVVLKGpggNRDGRSDYINASYLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKP
  |||| ..|  | .|| ||    ..    ||| | |..  .   . .| .|||.. .  |||.|..|||.  |..|    |  . ||  |||     . 
mhknrysdvvcldtsrvklki...dksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGQYTVSLCkNEAFADYTVRTFLV-----TVRLQQQRVGDEGLRFiYQYHFTVWPDKGVPQYATAVLrfRKKIINESRHntAPWIVHC
||   |.   .|.  .. .  . |      | ...|    ..||     ..  |||.|||.     .   .... . ||   | .|||
ygcirvtnl.sesseefeicnlavtfvpdnvpvdeqpanlkelrv.slikwpnwpdrgvpdekchtv..pqrllaqvrh..gpcvvhc

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 4-186 3.2e-22 73.5 In-house 56-228 (305) alignment
Range on Protein: 4-186
Range on HMM: 56-228/305.0
KIKNRYGNIVTYDHTRVVLKGPGgnrdgRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKP
. |||| ..   |.. | |. |       |||| | |.       |..|.||||.. . |.|| || |..   ||||   .|  | || .||| ..  | 
itknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

YGQYTVsLCKNEAFADYTVRTFLVTVRLQQ-QRVGDEGLRfIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHC
  .  . . .| . .    |   . . | .    ||. .  . . ..| |||.|||    . | .   |    |    | .|||
elksgi.vvenvsgskpmerdaeiqitllnltysgdqkms.vrhlqwtewpdrgvppckltslellsai....rgskvpivvhc

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4-111 2.4e-16 54.0 In-house 49-165 (349) alignment
Range on Protein: 4-111
Range on HMM: 49-165/349.0
KIKNRYGNIVTYDHTRVVLKG----PGGNRDG--------RSDYINASYLQGFDGT-PKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEK
  |||| .|. |.|.||.||     . . .            ||||| ||.    .  ||||| | |.  . |||....  ..  ... |.   | . ||
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHKYWPDTNqpkpYGQYTVSL
|..|| . .    | ..|| |
cdiywqels....ysnitvkl

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 5-186 3e-38 126.3 In-house 40-217 (287) alignment
Range on Protein: 5-186
Range on HMM: 40-217/287.0
IKNRYGNIVTYDHTRVVLKGPGgnrDGRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKPY
 ||||.... .|.|||.|   |   .  |||||| |. ..    ...||||||.  .  |||..|...| ......|  .|  . ||.||||. ..|   
kknryadvlPiddtrvllsaeg...elGsdyinanyvasytd.deafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

GQYTVSLCKN-EAFADYTVRTFLVTvRLQqqrvgDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKI---INE--SRHNTAPWIVHC
| |.| | .      .|.||.. .   |.      .  | . |...  ||||...  | ...||  ..   |.   .  .. | .||.
GGysvvlldydikePeygvralrli.dle.....trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 5-186 2.2e-32 106.9 In-house 58-223 (290) alignment
Range on Protein: 5-186
Range on HMM: 58-223/290.0
IKNRYGNIVTYDHTRVVLKGpGgnrdGRSDYINASYLQGfdgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN-QPKP
 |||| ..|  | |||.||  |    .  ||. | |..|   .   .| .||... .  |.|.|| ||. ..||||  |||  | ||..|.|... .   
kknrykdvvcndktrvilkd.G....ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGQYTVsLCKNEAFADYTVRTFLVTVRlqQQRVGDEglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHC
.|..|| || .|   |  .   ...||  ..  | |    .. ..   |||| |.. . |.||  . .    |. . | .|||
fGeitv.lcseeddkdaniikktlsvr..dkdsGke..hklkhlkikswpdksvalstlallrtlril....rkasGpvvvhc

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 5-172 2.8e-32 106.8 In-house 35-194 (297) alignment
Range on Protein: 5-172
Range on HMM: 35-194/297.0
IKNRYGNIVTYDHTRVVLKGPGGNrdgrSDYINASYLQGFD-GTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKP
 |||| .|...| ||| |..   .    .||||| |.   |  .. ||| ||||.. . ||||..|...   ||||.. | |. ..||  |||...| . 
rknryrdilatddtrvkllrvite....rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

YG-QYTVSLCkNEAFADYTvRTFLVTVRLQQQrvgdEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKII
   .. |     .   ..  | .|  ..|  .    .  | .    |  |||.|||     . ||. ...
kagdvvvefl.sstsdefd.rviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaqvc

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 5-100 1.3e-25 84.9 In-house 49-155 (350) alignment
Range on Protein: 5-100
Range on HMM: 49-155/350.0
IKNRYGNIVTYDHTRVVLK----GPGGNRD--GRSDYINASYLQGF----DGTPK-KYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHK
 |||| ||. |.|.|| ||     . . .     .|||||.||.      .  |. ||||.|.|.    |||.... .    ||..|| ..| | |||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDTNQ
||.. . 
YWqegsy

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 5-80 1.6e-10 35.0 In-house 39-116 (347) alignment
Range on Protein: 5-80
Range on HMM: 39-116/347.0
IKNRYGNIVTYDHTRVVLKgPGGNRDGRSD----YINASYLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVML
 |||  .    | |||||  |   . .|.|    |||||... || . |.|| .| |.  .  |||.||   . . .| .
sknrskdvklidatrvvls.peksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 6-186 4.1e-24 80.0 In-house 38-210 (285) alignment
Range on Protein: 6-186
Range on HMM: 38-210/285.0
KNRYGNIVTYDHTRVVLKgpggNRDgrSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN-QPKPY
 ||| ..   . ||||||    |.|   ||| ||...        ||..|||.  .  |||.|..||. . ..||  |.||  |||  |.|.   .   .
lnryadvrcieetrvvlk....nhd..rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GQYTVSL--CKNEAFADYTVRTFLVTvrlQQQRVGDEGLrFIYQYHFTVWPDKGVPQYATAVLRFRKKiINESRHNTAPWIVHC
|.| ..|  ||.|| |   . .. |.   . .    | | .. . .   |||.  |. |  .. . |  ...   .  |  |||
gkyeitlteckeeaiagtilnaltvi...ntedassepl.ymnhvqvpwwpdqlapedarpmielykw.vkkvnpkekpicvhc

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 6-186 3.6e-17 57.0 In-house 46-216 (312) alignment
Range on Protein: 6-186
Range on HMM: 46-216/312.0
KNRYGNIVTYDHTRVVLKGpggnrDgRSDYINASYLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ---PK
 ||| ||  .|  |  | |     |    || | ...     |......|||.| .|  |||..    .. |..|.|..|   ||| ||  |       .
lnrypniqcwdrgrftlag.....d.enfyihanfvk.ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

PYGQYTVSLCKNEAFA----DYTVRTFLVTVRlqqqRVGDEGLrfIYQYHFTVWPDKGVPQYATAVLRFrkkiINESRHNTAPWIVHC
 .  || .  . |         | | . | |.      |.|    . .| .. |||.|.|.   . ||.    .   ...  | | ||
dhrvyteycteieiggkskdkithrvlkvvvk....atgqesk..lnhyqwaswpdhgmpdscdtalrl....lsavkkdkkpviahc

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 6-90 2.8e-09 30.9 In-house 37-117 (332) alignment
Range on Protein: 6-90
Range on HMM: 37-117/332.0
KNRYGNIVTYDHTRVVLKgpggNRDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDD-FWQMVWQERCSVIVMLTGLIEGNKEK
 ||   .  .||.|| |      .||. |. |||...|.      || || |..   .  ||.|| . . |.|...  . | .| |
mnriphlycfdhsrvela....pqdgkddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_eak_pd Subfamily eak 9-169 1.9e-18 60.9 In-house 57-205 (332) alignment
Range on Protein: 9-169
Range on HMM: 57-205/332.0
YGNIVTYDHTRVVLKGPGGNRDGrsdYINASyLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN-QPKPYGQY
  .|| ||.  | |     ||.|   ||||| |  |    .||| .  . |     ||||| ...   ||.|   .| . ||  ||.||   .   .|..
vvkivpydrylvrltssqlnrlG...yinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

TVSlCKneafaDYtVRTFLVTVRLQQQRVGDEGLRfIYQYHFTVWPDKGVPQYATaVLRFRK
 |  .|     .. |.   . .|| . ..|.|  | .. |..  | .  .|.|    | .||
dve.rk.....ef.vkrniletrllelskGnethr.vlhykvfGwtettlpkyed.flalrk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 14-186 1.6e-11 38.9 In-house 29-198 (290) alignment
Range on Protein: 14-186
Range on HMM: 29-198/290.0
TYDHTRVVLKGPGGNrdGRSDYINASYLQGFDGTpkKYIAAQGPVEPS-------CDDFWQMVWQERCSVIVMLTGLIEGNKE----KCHKYWPDTNQ-P
   .||||||| |      .||| |....  .|   . |. | | |           .|| |. ||.   .|||    | ...     | || |..    
LveatrvvLkgygkr..fnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee

KPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHC
  ..  ||. .. |.  |  .|. .|.        .||    .  . .  | .  |..    .|   .|.    . ...| ||||
lkfkgltvkCkskekeddvetRelvvkf.......ddeeeftvtHsllkgWnklnvqedtktllsliqkv....kasktpvivHc

0044763 (Phosphotyrosine protein) phosphatases II 15-186 3.7e-18 61.2 In-house 2-117 (178) alignment
Range on Protein: 15-186
Range on HMM: 2-117/178.0
YDHTRVVLKGPggNRDGRSDYINASYLQGFdgtpkKYIAAQGPvepscDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQpkpygqytvslckn
.|.|||.|  .   .  ||||||||.  ..      |.....|      |........ ...||.||. .|....||..|||. .               
ldrtrvllsnl..eglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............

eafadytvrtflvtvrlqqqrvgdeglrfiYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
                              .||... .|| |||.    .|.| . | .    .  | .|||
..............................iqylhipipDhgvpdllehflefvefieealdekggpvlVHC

0046846 (Phosphotyrosine protein) phosphatases II 30-186 2.8e-23 78.0 In-house 9-116 (176) alignment
Range on Protein: 30-186
Range on HMM: 9-116/176.0
DGRSDYINASYLQGFdgtpkKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKPygqytvslckneafadytvrtflvtv
|. .|||||... |      ..|| |||.. .. ||..|.........|.|| ..| .. ||. |||.  ...                           
dldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

rlqqqrvgdeglrfiyQYHFTVWPDKGVPQYaTAVLRFRKKIINESRHNtAPWIVHC
                ||... ||| |||.. ...|.. . | .  ...  | .|||
................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHC

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 30-186 4.7e-21 69.8 In-house 72-221 (301) alignment
Range on Protein: 30-186
Range on HMM: 72-221/301.0
DGRSDYINASYLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPD-TNQPKPYGQYTVSLCKNEAFADYTVRTFLVT
||.   | | ...   | |...||.|||.. ...||| |. |     ||||.  .| ..|||..| |  ...    |.... . ..|   .  .    . 
dGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtle

VRLQQqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRkKIINESrhnTAPWIVHC
|.      |.   | .  | .. |.|.|||.  . .  .  ... .|     | .|||
vedst...gkfatrtvthyqysewtdrgvPkshaelfdlm.elvkks...ekPivvhc

0043147 (Phosphotyrosine protein) phosphatases II 30-186 6.4e-21 70.3 In-house 2-107 (172) alignment
Range on Protein: 30-186
Range on HMM: 2-107/172.0
DGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLiegnkekchkywpdtnqpkpygqytvslckneafadytvrtflvtv
|..||||||||| .    |...|| |||    ..|||.|.... ...||.||.|                                              
degsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel..............................................

rlqqQRVGDEGLRFIYQYHFTVWPDKGVPqYATAVLRFRKKIIN-ESRHNTAPWIVHC
    .  ..   |...||... ||| |||  .  .|.| . | .   . .  | .|||
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHC

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 32-119 6.7e-09 30.1 In-house 12-94 (130) alignment
Range on Protein: 32-119
Range on HMM: 12-94/130.0
RSDYINASYLqGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLtglieGNKEKCHKYWPDTNQPKPYG-QYTVSLCKNEAFAD
  .|||||.. |  |  ..|. .| |.  .. |||.|. .    |.|.|     |  |.  .||||..  . |  . .|.| . . |  
gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.....gsveeedeywpdsePlewyeediivtltdrdefkn

0051429 (Phosphotyrosine protein) phosphatases II 33-186 1.8e-31 105.2 In-house 4-157 (272) alignment
Range on Protein: 33-186
Range on HMM: 4-157/272.0
SDYINASYLQGFdGT---PKKYIAAQGPVEPSCDDFWQMvWQERCSVIVMLTGLIEGNKEKCHKYWP-----------DTNQPKPYGQYTVSLCKNEAFA
|.||||... |. |    |.......|| . ...|||.. .......||.|... | ...||..|||           |. ..  ||...| | . | . 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYTVRTFLVTVRLQQQRVgdeglRFIYQYHFTVWPDKGVPQYAtaVLRFRKKIINesrhnTAPWIVHC
||..|..|.|  |. . .     | ....|.| ||| |||| |  .|.. . . .       | .|||
dyilrellltlllsagea.....revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHC

0036282 (Phosphotyrosine protein) phosphatases II 33-186 9.2e-24 79.5 In-house 2-111 (174) alignment
Range on Protein: 33-186
Range on HMM: 2-111/174.0
SDYINASYLQGFDGTPkKYIAAQGPVEpscddFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtnqpkpygqytvslckneafadytvrtflvtvrlq
|||||||.| ..  || ..|| ||| .     ||.|.........|||. ..| ...||. |||.                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

qqrVGDEGLRFIYQYHFTVWPDKGVPQYATaVLRFRKKIINESRH-NTAPWIVHC
     .   |...||... ||| |||  .. .|.| | . .   . .  | .|||
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

0051082 (Phosphotyrosine protein) phosphatases II 33-186 2.6e-19 64.8 In-house 3-99 (151) alignment
Range on Protein: 33-186
Range on HMM: 3-99/151.0
SDYINASYLQGFdgtpkkYIAAQGPVEpscdDFWQMVWQERCSVIVMLTGLIEGNkeKCHKYWPDTNqpkpygqytvslckneafadytvrtflvtvrlq
|||||.||. |.      ... .|| .    ||....... ...||.|... | .  .|..|.|...                                 
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qqrvgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINesrHNTAPWIVHC
         . ....... ||| |.|..  |||.| .....   ..  | .|||
.........ievlhipildwpdpglplsfdavleflellld...kkngpvlvHC

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 43-125 4.7e-10 33.4 In-house 228-309 (440) alignment
Range on Protein: 43-125
Range on HMM: 228-309/440.0
GFDGTPKK--YIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLiegNKEKCHKYWPDTNQPKPYGQYTVSLCKNEAFADYTVRTF
 |.|  ||  .||.| |.. .  |||..| . | | |.||  |   |   |  |||   .   .| .||     | .    |||.
efegyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtl

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 44-167 5.9e-14 46.2 In-house 83-213 (302) alignment
Range on Protein: 44-167
Range on HMM: 83-213/302.0
FDGTPKKYIAAQGPVEP---SCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP-KPYGQYTVSLCK-NEAFADYTVR--TFLVTVRLQQQRV
 ||| ||   .. |. |   ... .| .. | . ...| |....|....|| .|. |  .    .|.|||   . .. ....| .    | || .. ...
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

GDEGLRFIYQYHFTVWPDKGVPQYATAVLRF
 ..  . .   .|. |||.| |. | . |  
kkkvkktvdilafsawpdhGapkeaytaldi

0049260 (Phosphotyrosine protein) phosphatases II 47-186 1.2e-20 69.2 In-house 7-96 (152) alignment
Range on Protein: 47-186
Range on HMM: 7-96/152.0
TPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWpdtnqpkpygqytvslckneafadytvrtflvtvrlqqqrvgdeglrfiyQ
 |...||.||| . ...|||.|...  ...||||| | | .|.||..|.                                                  |
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................q

YHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
|... ||| |||. .  .| . . |    ...  | .|||
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHC

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 49-186 8.5e-16 52.7 In-house 5-142 (199) alignment
Range on Protein: 49-186
Range on HMM: 5-142/199.0
KKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLiEGNKE-KCHKYWPDTNQP-KPYGQYTVSLCKNEAFADYTVRTFLVTvrlqQQRVGDEGLRFIYQ
..|||.| |.  .  |||||||.     |||.    . |||     ||| |.     ||  .|.     . .|||. ....|    ..       | | .
rryiatqhplretmadfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitalilt....nnttappstreish

YHFTVWPDKGVPQYATA---VLRFRKKIINESRHNTAPWIVHC
| || | .|  |. |     |.  |.   .  . . || ||||
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhc

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 49-186 8.8e-16 52.7 In-house 4-141 (198) alignment
Range on Protein: 49-186
Range on HMM: 4-141/198.0
KKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLiEGNKE-KCHKYWPDTNQP-KPYGQYTVSLCKNEAFADYTVRTFLVTvrlqQQRVGDEGLRFIYQ
..|||.| |.  .  |||||||.     |||.    . |||     ||| |.     ||  .|.     . .|||. ....|    ..       | | .
rryiatqhplretladfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitalilt....nnttappstreish

YHFTVWPDKGVPQYATA---VLRFRKKIINESRHNTAPWIVHC
| || | .|  |. |     |.  |.   .  . . || ||||
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhc

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 61-186 1.1e-14 49.1 In-house 40-155 (255) alignment
Range on Protein: 61-186
Range on HMM: 40-155/255.0
SCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKPYgQYTVSLCKNEAFADYTVRTFLVTVRLQQQRVGDEglrfIYQYHFTVWPDKGVPQY
. | |.|.. | . .|.|||. . | ..|||..|.|   . |      |...  .. ||  .||  .|  | ...  ..    .  |... |..|  |. 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklk.ladvnvtttkssadvvlrtleitstlgekkktht....vkhysykGWieknaPel

ATAVLRFRKkIINESRhntaPWIVHC
|  .|   | .. .|.    . .|||
areilnilk.vvrdsk....svvvhC

subfamily_hpo-7_pd Subfamily hpo-7 62-168 9.7e-12 39.3 In-house 47-148 (263) alignment
Range on Protein: 62-168
Range on HMM: 47-148/263.0
CDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKPyGQYTVSLCKNEAFADYTVRTFLVTVRLQQqRVGdegLRFIYQYHFTVWPDKGVPQYA
 | |.|.. | . .|.|||.   | ..||| .|.|     |      |..|  ..  |  ..|  ..  |.. .     .. . .| .. |..|  |. |
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekq.klanvnvcttkvqsdvllktlellstlge.Kkk...thtvkhysykgWiekndpela

TAVLRFR
  .|.  
reilnil

0048076 (Phosphotyrosine protein) phosphatases II 94-186 3.8e-07 25.4 In-house 2-88 (145) alignment
Range on Protein: 94-186
Range on HMM: 2-88/145.0
YWPDTNQPKPYGQYTVSLCKNEAFADYTVRTFLVTvrlqqQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNtAPWIVHC
|||.   |. |     . .. | ..|. ..| |        .  .   |...||... ||| |||. .  .|.| . | .  ...  | .|||
ywpseilpglylgslptaldlellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHC

0048179 (Phosphotyrosine protein) phosphatases II 95-186 2.1e-07 26.3 In-house 3-90 (144) alignment
Range on Protein: 95-186
Range on HMM: 3-90/144.0
WPDTNQPKPYGQYTVSLCKNEAFADYTVRTflvTVRLQQQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRhNTAPWIVHC
.|.   |. |     .... | .... ..|    ..|. ..  ..  |...||... ||| |||.... .|.| . | .  . .  | .|||
npseilpglylgslptaldlellkklgitt...vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHC

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 142-186 5.9e-07 23.2 In-house 89-134 (440) alignment
Range on Protein: 142-186
Range on HMM: 89-134/440.0
RFIYQYHFTVWPDKGVPQYATAVLRFRKKiINESRHN--TAPWIVHC
| . |||.  |||||||..|  ||.. .  .|||...   .| .|||
rtlkqyhyqgwpdkgvpkfagpvlkmiqd.vnesqekagngpllvhc

PTPc_DSPc_SM00012 144-186 3.1e-08 29.1 In-house 2-46 (105) alignment
Range on Protein: 144-186
Range on HMM: 2-46/105.0
IYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT--APWIVHC
...||.| |||.|||......|.. ... .. ....  .| .|||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhC