Gene NvecPTP-sf4-4 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP061_AA protein Get Run
NvecP061_AA_0-186 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-186 1.8e-110 362.8 In-house 1-179 (237) alignment 
Range on Protein: 1-186
Range on HMM: 1-179/237.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrdgrSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
.||||||||||||.|||.||||||.|..    ||||||.||.|||||||||||||||.|.||||||||||||.||||||||||||||..|||||||.|.|
senkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQrvgdeGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHC
|..||..||||.|.|.|.|||||..|...||...     ..|.|.||.||.|||.||||...|.|||||.|||.|.|  ...|||.||
paaygvltvslkkkeefsdytvrslllskrltlk.....evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihc
subfamily_PTPRD_pd Subfamily PTPRD 1-186 1.1e-77 257.0 In-house 46-221 (564) alignment 
Range on Protein: 1-186
Range on HMM: 46-221/564.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNq
|.|| |||| ||| |||.||||.   |.    |||||||...|.. ..|.|||.|||......|||.|||....|.||||| | | .|.|||||||... 
paNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.

PKPYGQYTVSLCKNEAFADYTVRTFLVtVRLQQQRVgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. ||..||.| ..| .|||..||| .  . ... .     | . |.||| |||.|||..||..|....|. . ..... |..|||
tetygeltVtleeeeeladyeirtfkl.kkkksses.....reVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhC
0050432 (Phosphotyrosine protein) phosphatases II 1-186 2.8e-64 212.7 In-house 66-239 (308) alignment 
Range on Protein: 1-186
Range on HMM: 66-239/308.0
PENKIKNRYGNIVTYDHTRVVLkgpggnrDGRSDYINASYLQGFD-GTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-
|||| |||| .|. |||.||.|       |. |||||||| .|.. . |.|.||.||| . ...|||.|||.....|||||| |.| ..|||..|||.. 
penkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplel

-NQPKPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESrhNTAPWIVHC
 .... ||..|| | . | ..||||||. .|       .||.  |.....|.| ||| |||......|.| ... .    .  | .|||
gggsleygkftvtllseevlddytvrtleltn......lgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHC
0051299 (Phosphotyrosine protein) phosphatases II 1-186 7.5e-64 211.3 In-house 47-226 (288) alignment 
Range on Protein: 1-186
Range on HMM: 47-226/288.0
PENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
|||. |||| .|. |||.||.|. ..|  .. ||||||||..|.. . | .||.||| . ...|||.|||.....||||||.|.| ..|||..|||. ..
penleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.gg

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRL--QqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. ||..|| | . | ..||||||. ||     .    ||.  |.....|.| ||| |||......|.| .....  ...  | .|||
sltygditvtllseevlddytvrtlevtnldlld....gdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHC
0046845 (Phosphotyrosine protein) phosphatases II 1-186 9.5e-64 210.8 In-house 26-211 (284) alignment 
Range on Protein: 1-186
Range on HMM: 26-211/284.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASYLQGFD----GTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWP
|||. |||| .|. |||.||.|| ..|. .. ||||||||..|.|     ..||.||.|||.. ...|||.|||.....||||||.|.| ..|||..|||
penlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwp

DTNQPKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrvG-DEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR--HNTAPWIVHC
...... ||..|| | . | . ||||||. .|        | ..  |.....|.| ||| |||.... .|.| ... .  .  ..  | .|||
legevltygdftvtllseevkddytvrtleltnl......gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHC
0036941 (Phosphotyrosine protein) phosphatases II 1-186 1.6e-61 203.6 In-house 37-214 (297) alignment 
Range on Protein: 1-186
Range on HMM: 37-214/297.0
PENKIKNRYGNIVTYDHTRVVLkgpggnRDGRSDYINASYLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-N
|||. |||| .|. ||||||.|       |. ||||||||..|. . ..|.||.||| . ...|||.|||.....|||||| |.| ..|||..|||.. .
penleknRykdilpydhtRVkl......ddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeg

QPKPYGQYTVSLCKNEA--FADYTVRTFLVTVRlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHC
... ||..|| | . |   ..|||.||. ||        |..  |.....|.| ||| |||.... .|.| ... .  ..  .  | .|||
esltygdftvtllsvevvllddytlrtlevtdt......gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHC
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-186 2.3e-61 202.1 In-house 7-182 (250) alignment 
Range on Protein: 1-186
Range on HMM: 7-182/250.0
PENKIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEkCHKYWPdTNQ
|.|| |||| .|...|..||||.      |  |||||||.|.|.|.. | .||.|||....  |||.||..|  ..||||| | | .|. .|.||| ...
pqnkeknryadiialdssrvvLekek..gdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.vek

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRvgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH-NTAPWIVHC
.. ||. |||| ..| |||||.|.. .. . ....      | . |.||.||||||||..||||| ..||.  . .. ..|| ||.|
aekyGdvtvsllskeefadytkrklklskakkade......rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqC
0040438 (Phosphotyrosine protein) phosphatases II 1-186 6e-61 201.8 In-house 41-216 (317) alignment 
Range on Protein: 1-186
Range on HMM: 41-216/317.0
PENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
|||| |||| .|. |||.||.|. .||  |  |||||||| .|.. ..| .||.||| . ...|||.|||.....|||||| | | ..|||..|||. ..
penkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.ge

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. ||..|| |.. |  |..|.||. |.        ||.  |.....|.| ||| |||.. . .|.| ... .  ...  | .|||
tltygdftvtllseeelagitlrtlevedl......gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHC
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-186 1.1e-59 197.2 In-house 54-230 (298) alignment 
Range on Protein: 1-186
Range on HMM: 54-230/298.0
PENKIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASYLQGFDGTPkKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNq
|||| |||| .|...|..||||.      |  |||||||.|....|..  .||.|.|....  |||.||..|  ..||||| | | .| |.||||||.. 
penkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdeg.

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQqrvgdeGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT-APWIVHC
 . ||. |||| ..| |||..||.. |. . ..      . | . | |||.|||||||..||.|| ...|.    ...  .| ||.|
ketygeitvsllskeefadlivrklkvskkkee......kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqC
subfamily_PTPN6_pd Subfamily PTPN6 1-186 2.8e-59 195.6 In-house 52-234 (306) alignment 
Range on Protein: 1-186
Range on HMM: 52-234/306.0
PENKIKNRYGNIVTYDHTRVVLKgpgGNRDGRSDYINASYLQ-GFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN
|||| |||| ||. .|||||.||    .    ||||||.|..  . |. |.|||.|| .|    |||.||||| . ||||.|  .| .|||| .||||..
penkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee

QPKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT----APWIVHC
. . ||...|. ..... |||..|...|. .       ..  | ..||||..|||.|||.   ||| | ... ..... .     | .|||
ekeeyGkisvtnvseksladYilRelsvskk.....kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhC
0047943 (Phosphotyrosine protein) phosphatases II 1-186 1.6e-58 193.7 In-house 36-212 (273) alignment 
Range on Protein: 1-186
Range on HMM: 36-212/273.0
PENKIKNRYGNIVTYDHTRVVLkgpggnRDGRSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
|||| |||| .|. |||.||.|       || ||||||||..|.. ..| .||.||| . ...|||.|||.....|||||| |.| ..|||..|||....
penkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwplegg

--PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLqqqrvgDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHC
  .. ||..|| | . | ..||||||. .|         ..  |.....|.| ||| |||.. . .|.| ... .  ..  .  | .|||
elsltygkftvtllseetkddytvrtleltnlg......tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC
subfamily_PTPRG_pd Subfamily PTPRG 1-186 1.7e-58 193.2 In-house 45-227 (563) alignment 
Range on Protein: 1-186
Range on HMM: 45-227/563.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
|||| |||| |||.||..|| |..  |. ... |||||.|..|.    |..||.|||..  .||||.|.|... ..|||.| | | ...||. |||  ..
penkrKnRylnivaydrsRvklsplpgk.kkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.de

PKPYGQYTVSLCKNEAFADYTVRTFLVTV-RLQQQRVgDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. ||. .| | ..| .| |||||. .   .|....   .  . ..|||.| |||.|||.... || | ||     .... | .|||
setygalqvtlieeevlalytvrtlviknlklkkkkq.cdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHc
0045450 (Phosphotyrosine protein) phosphatases II 1-186 1.8e-58 194.1 In-house 53-241 (307) alignment 
Range on Protein: 1-186
Range on HMM: 53-241/307.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASYL--------QGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCH
|||| |||| .|. ||||||.|. ..|. .. ||||||||         .|.|  ..|.||.||| . ...|||.|.|.....||||||.|.| ..|||.
penkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekca

KYWPDTNQPKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN--ESRHNTAPWIVHC
.||||..... ||..|| | . |  ..|||||. ||        |..  |.....|.| ||| |||..   .|.| ... .  |.  .  | .|||
qywPdegeeltygnftvtllseehldgytvrtlevtdl.....dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHC
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-186 4.2e-58 191.7 In-house 45-219 (288) alignment 
Range on Protein: 1-186
Range on HMM: 45-219/288.0
PENKIKNRYGNIVTYDHTRVVLKGpgGNRDGRSDYINASYLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
..|. |||| ||..||..|| ||.  ..    .|||||||..| ..  |||||.|||.  . .|||..|.... | |||||.|.||.|.||..||||...
avnakknRyrnilpyDekrvklkk..leeeagaDYinasyidg.ekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadk

PKPYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
|| ||. || | ...   |...|..|.          ... . | ||....|||.|||. .. .| ..... . .  .| | ||||
pknyGsvtvtlveskeledfvlrkllle........kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhC
0039614 (Phosphotyrosine protein) phosphatases II 1-186 1.7e-57 190.5 In-house 54-229 (297) alignment 
Range on Protein: 1-186
Range on HMM: 54-229/297.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKeKCHKYWPDTNQ
|||| |||| .|. |||.||.||...|  |  ||||||||..|.| ...|.||.||| . ...|||.|||.....|||||| |.| .. ||..|||.. .
penkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg

pkPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrvgDE-GlRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHC
   ||..|| | | |  ..|||||. ||         ..   |.......| ||| |||.... .|.| ... .  ..  .  | .|||
..tygdftvtllkvehldgytvrtlevtn........nges.rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHC
0043336 (Phosphotyrosine protein) phosphatases II 1-186 3.7e-57 189.2 In-house 43-217 (278) alignment 
Range on Protein: 1-186
Range on HMM: 43-217/278.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPdtNQ
|||| |||| .|. |||.||.|.  ||  |  ||||||||. |.. ..| .||.||| . ...|||.|||......|||||.| | ...||..|||  ..
penkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..gg

PKPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. ||..|| | | | ..||||||. ||        ||   |....||.. ||| |||   . .|.| |....  ...  | .|||
sltygdftvtllkeehlddytvrtlevtn......lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHC
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-186 7.9e-55 181.1 In-house 46-223 (319) alignment 
Range on Protein: 1-186
Range on HMM: 46-223/319.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNq
.||| |||| ||..||.|||||.   |  .  |||||||...|..   .|.||.|.|.|   .|||.|||.|..|..||||.| |  | |..||||..| 
eenkkknryqnilaydrtrvvlseldgveg..sdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen.

PKPYGQYTVSLCKNEAFADYTVRTFLVtvRLQQQRVGDeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR-HNTAPWIVHC
.. ||...| | ..|  .|| .| . .  . ... |     | . ....| |||..||..||..| . |.| .  . ..  | .|||
feeyGrlivtleeeeeledyiirklkl..nkkssevet...RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhC
0045098 (Phosphotyrosine protein) phosphatases II 1-186 1.6e-54 180.5 In-house 31-213 (278) alignment 
Range on Protein: 1-186
Range on HMM: 31-213/278.0
PENKIKNRYGNIVTYDHTRVVlkgpggnrdgrsDYINASYLQGFdgtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
..|. |||| .|. |||.||.            |||||||..|.   |||.||.||| .  ..|||.|.|.....||||||.|.|...|||..|||. ..
lgnldknRykdilpydhsrVk............dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.gg

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRVGDegLRFIYQYHFTVWPDKGVPQYA--TAVLRFRKKIINESRH-------------NTAPWIVH
.. ||..|| | . | . |||.||.|||    ..  .    |.....|.. ||| ||| .   . .|.. . | .  ..             .  | .||
sltygdftvtllseevlddytlrtllvtnltveredle..srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

C
|
C
0040439 (Phosphotyrosine protein) phosphatases II 1-186 1.7e-53 177.1 In-house 9-186 (249) alignment 
Range on Protein: 1-186
Range on HMM: 9-186/249.0
PENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
|||| |||| .|. |||.||.|.  .|     ||||||||. |.. ... .||.||| . ...|||.|.|.....|||||| | | ..|||..|||. ..
penkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.gg

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHC
.. ||..|| | . | ..||||||. .|        .|   | ......| ||| |||..   .|.| ... .  ..  .  | .|||
sleygdftvtllsvevkddytvrtleltnl......ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHC
0042113 (Phosphotyrosine protein) phosphatases II 1-186 5.9e-53 175.1 In-house 7-183 (245) alignment 
Range on Protein: 1-186
Range on HMM: 7-183/245.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQ
|||| |||| .|. ||||||.|. .||. |  ||||||||  |.. ||| .||.||| . ...|||.|.|......||||| . | ...||..|||. ..
penkdknrysdilpydhtrvklspdggdld..sdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR-HNTAPWIVHC
.. ||..|| | . | ..||||||. ||        ||   |....||.. ||| ||| .   .|.| . . .  . ..  | .|||
sltygdftvtllseehlddytvrtlevtnl......gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHC
0037934 (Phosphotyrosine protein) phosphatases II 1-186 1.3e-51 170.9 In-house 8-185 (243) alignment 
Range on Protein: 1-186
Range on HMM: 8-185/243.0
PENKIKNRYGNIVTYDHTRVVLkgpggnrDGrSDYINASYLQGFDgtpkKYIAAQGPVEPSCDD----FWQMVWQERCSVIVMLTGLIEGNKEKCHKYWP
|||. |||| .|..|||.||.|       .| ||||||.. ....    ..|| ||| . ...|    ||.|.|.....|||||| |.| ..|||..|||
penlsknrysdilpydhsrvkl.......eg.sdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dtNQPkPYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqRVG-DEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINE--------SRHNTAPWIVHC
  ..   ||..|| | . | ..||||||.|..      ... |.  |....||.. ||| |||.  . .|.| .....          ...  | .|||
..gev.tygdftvtllseehlddytvrtllle......nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-186 2.2e-51 169.4 In-house 44-223 (290) alignment 
Range on Protein: 1-186
Range on HMM: 44-223/290.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
..|| .||. ||| ||  |..|.  .|..|   .||||.|..|.    |.|||.||||.    |||...|||....|||||  || .|.||..||||...
ssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdt

PKpYGQYTVSLCKNEAFADYTVRTFLVTVRLQQqrvgdEGLRFIYQYHFTVWPDKG-VPQYATAVLRFRKKIINESRHNTAPWIVHC
 . ||.... | ..|.. .|. |.. |. . ..     .  . . ||..| |...| |....| .| ... . .. ..   . .|||
ka.ygefsikllneetlneyierklevknknsa.....gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHC
subfamily_PTPN3_pd Subfamily PTPN3 1-186 7.2e-50 164.5 In-house 39-215 (280) alignment 
Range on Protein: 1-186
Range on HMM: 39-215/280.0
PENKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASYLQ-GFDG--TPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPD
|||  |||| .|..||.||| ||      ....|||||.|..   ..  . ..|||.|||.. .. |||||||....|.||||| |.|  . |||.|||.
penlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

TNQPKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRvgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
|..   ||...| . |...   | .| .... . ....      | | |  .. |||.|||. .. .|.| ... .  . .. | .|||
tedeleygefsvkcekedetksyvlrelvlkdketkee......rkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-186 3.2e-48 159.7 In-house 59-231 (319) alignment 
Range on Protein: 1-186
Range on HMM: 59-231/319.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTgliegnKEKCHKYWPDTNQ
..|| |||..||...|...| |.   |     |||||||...|.   ..|||||||| . . .|||.|.|. .|| ||.||      |.|| .|||   .
dqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

PKpYGQYTVSLCKNEAFADYTVRTFLVTvrlqqQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKK--IINESRHNTAPWIVHC
 | .... |..   |  |.|.|| . ..     .    .. | | |.||  |||.|||.|.. ..|. ||   ...  .. |. .|||
ik.eerfkvkvdsveetaeyvvrdiels.....edgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhc
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1-186 1.2e-47 157.8 In-house 23-195 (284) alignment 
Range on Protein: 1-186
Range on HMM: 23-195/284.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTgliegnKEKCHKYWPDTNQ
..|| |||.|.|...|...| |.   |.    |||||||...|.   ..||||.||| . . .|||.|.|. .|| ||.||      |.|| .|||   .
dqnkdknrighilafdknvvklerliGee..fsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

PKpYGQYTVSLCKNEAFADYTVRTFLVTvrlqqQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKK--IINESRHNTAPWIVHC
 | .... |..   |  ..|.|| . ..     .    .. | | |.||  |||.|||.|.. ..|. ||   ...  .. |. .|||
ik.eerfkvkvdsveeseeyvvrdiels.....edgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc
subfamily_PTPN1_pd Subfamily PTPN1 1-186 4.6e-42 138.7 In-house 30-208 (290) alignment 
Range on Protein: 1-186
Range on HMM: 30-208/290.0
PENKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASYLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
|||. .||| ..  |||.|..|.      ..  |||||| .. ..   ..|| .|||.   .| ||||||....  .|||  ..| .. ||..|||  ..
penrnlnryrdvspydhsrikle......radndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

P----KPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINES--RHNTAPWIVHC
         ...| | ..|    ||||.. ..       .  .  | |...|.| ||| |||.  .| |.|  |. .     ..  | ..||
ekellledtklkvkliseerksyytvrllelen......lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihc
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-186 1.9e-40 134.0 In-house 46-228 (325) alignment 
Range on Protein: 1-186
Range on HMM: 46-228/325.0
PENKIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMV--WQerCSVIVMLTgLIEGNKEKCHKYWPDT
|||| |||. |.|..|..||||.  .   |. |||||||||. . .  . ..||| |   . .|.|..|  |.  |||.|.|   ....|..| .|||. 
penkaknrfknvvaldksrvvletkk..ddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr..csvvvvln.eldlgkdrcavywpke

-NQPKPYGQYTVSLCKNEAFADYTVRTFLVtvrlQQQRVGDegLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN--E----SRHNTAPWIVHC
  . | .|   |.|   | ..||  | . |    .| . |.   | . |...  |.| ||... .... . . . .  |      . ..| .|||
mgksktfGglevklrtieeisdyvhrvldv....kqvkkGe..trsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc
subfamily_PTPN14_pd Subfamily PTPN14 1-186 3.6e-38 126.3 In-house 47-236 (300) alignment 
Range on Protein: 1-186
Range on HMM: 47-236/300.0
PENKIKNRYGNIVTYDHTRVVLKGpggNRDGRSDYINASYLQGF-DGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-
|||. |||. ... |...|| |.    ... ...||||| ..    |. ..||.||||.|  . |||||||..  ..|||||  .|. |||..||.|.. 
penaeknrfkdvlPyednrvelsp...tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkle

--NQPKPYGQYTVSlcknEAFADYTVRtfLVTVRLQQQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR---------HNTAPWIVHC
  ..   .|.. |.    . | . . .  ..|  |. . .  .  | ..   .| |||.|||.  .  | . ...    |         ..  | .|||
skkktvefgkfkvt....tkfsedsds..vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1-186 1.4e-29 97.6 In-house 35-207 (281) alignment 
Range on Protein: 1-186
Range on HMM: 35-207/281.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDgRSDYINASYLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
| |. |||| ||   | .|| ||    |..  .||| | |..      . || .||| . .  |||.|.|||  . ||||  ..| |.||| .|.|   .
pvnnkknrylnipcldisrvqlkvkmpnkn.stdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

PkpYGQYTV-SLckneAFADYTVRTFLVTVRLQQQRVGDegLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHC
     |.   |.    .. | ||   ||| ||.    |.   |.| .. .  |||  ||. .  .|.  .||    |  ..| ..||
c..clqfdklsv....syedstvnkslvttrlnlsyege..trlithwlwkewpdwqvpessevmlkilrki....rarstppvihc
0049772 (Phosphotyrosine protein) phosphatases II 1-186 1.1e-26 89.8 In-house 44-219 (314) alignment 
Range on Protein: 1-186
Range on HMM: 44-219/314.0
PENKIKNRYGNIVTYDhTRVVLkgPGGNRDGrSDYINASYLQGFdgtpKKYIAAQGPVEPSCDDF----------WQMV--WQERCSVIVM---------
..|. |||| .|. .| .||.|  || . .| ||||||||. ||    .|.||.||| |  ..||          |.||  .. .. .|||         
flnrdknryldilpad.nrvil..pglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTGLIEGNKEKCHKYWPDTNqpkpygqytvslckneafadytvrtflvtvrlqqQRV--GDEGLRFIYQYHFTVWPDKGVPqYATAVL
            |..| ... | . ..... .                                  ...  ..   | ...|. . .|| ..|     ..
lsrLdaAlgKtpllildgngneptaadlellk..................................eelydpelferlgikylripvpDgsap.lledfd

RFRKKIINEsrHNTAPWIVHC
.| . | .   ..  | .|||
eflefieea..dkggpvlvHC
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1-117 4.7e-13 43.3 In-house 94-201 (244) alignment 
Range on Protein: 1-117
Range on HMM: 94-201/244.0
PENKIKNRYGNIVTYDHTRVVL-KGPGGNrdgrsDYINASYLqGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLtglieGNKEKCHKYWPDTN
|.|  ||| |  . .|  || | ||  ||      |||||.. |  |   .|| .| |.  .  |||.|. .    |.|.|     |  |.  .||||..
pnnswknregaglpfdfnrvplskgsmgn.....tyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvl.....gsveeedeywpdse

QPKPYG-QYTVSLCKNEAF
  . |  . ||.|   . |
plewyeeditvtltdrdef
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1-46 4.6e-10 33.4 In-house 45-88 (440) alignment 
Range on Protein: 1-46
Range on HMM: 45-88/440.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDG
|.||.|||| ||..|||.||.|.   |  |  ||||||||..| . 
pnnkvknryrnilaydhsrvmleevkgvpd..sdyinasyingies
subfamily_PTPRB_pd Subfamily PTPRB 2-186 7.4e-60 197.5 In-house 50-225 (293) alignment 
Range on Protein: 2-186
Range on HMM: 50-225/293.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP
.|. |||| ||..|||.|| |.    . .  ||||||.|..|.  .|...||.|||.  . ||||.|||....|.||||| |.|. |.||..|||....|
vnraknrytnilpydhsrvkLaal..kdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeep

KPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrvgDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINES--RHNTAPWIVHC
  ||. .|.| ..|   |...|.....         ..  | . ||||| ||| |||. ....|.| ... ..    ....| .|||
vlyGdikvtlvaeeeledwvirelkiek........ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhC
DSPc_SM00195 2-186 4.5e-58 192.0 In-house 25-202 (263) alignment 
Range on Protein: 2-186
Range on HMM: 25-202/263.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASYLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-NQ
.|| |||| ||. |||||| || . ..    ||||||.|..|    .|||||.||| .  ..|||.|||.|....|||||   | .||||..|||.. ..
knksknRyknilpydhtrVklkkeekk..egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesgg

PKPYGQYTVSLCKNEAFA-DYTVRTFLVTVRLQqqrvgdEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. .|...| | ..|    ....||. .|   .      |  |...||... |||.|||. .. ||.. ... ........| .|||
ketfgkisvklvevekkkdeiilrtleltkegk......eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC
PTPc_SM00194 2-186 4.5e-58 192.0 In-house 25-202 (263) alignment 
Range on Protein: 2-186
Range on HMM: 25-202/263.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASYLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-NQ
.|| |||| ||. |||||| || . ..    ||||||.|..|    .|||||.||| .  ..|||.|||.|....|||||   | .||||..|||.. ..
knksknRyknilpydhtrVklkkeekk..egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesgg

PKPYGQYTVSLCKNEAFA-DYTVRTFLVTVRLQqqrvgdEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.. .|...| | ..|    ....||. .|   .      |  |...||... |||.|||. .. ||.. ... ........| .|||
ketfgkisvklvevekkkdeiilrtleltkegk......eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-186 1.2e-57 190.2 In-house 40-215 (281) alignment 
Range on Protein: 2-186
Range on HMM: 40-215/281.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP
||. |||| ||| ||.|||...    ...  .|||||....|..| .|.|||.||||  |...||||||... |.|||.|  ||..| |||.|||| |. 
envlknrYsnivaYDatrvkvtpn..eenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnse

KPYGQYTVSLCKNEAFADYTVRTFLVtvrlqQQRVGDEglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT-APWIVHC
  ||..||.  ..|. | |  |.| .     ... |..  | . | ..| |||.|||. ....| |||.. . ....| || ..||
lkygdvtvkstaeeekatyierkfkl.....eresget..reveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihC
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-186 2.4e-56 186.1 In-house 45-220 (318) alignment 
Range on Protein: 2-186
Range on HMM: 45-220/318.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtNQP
 || |||| ||..|||||| |.   |.    ||||||.|..|.    |.|||||.|.   ..|||.|||.  ..|||||| . |  |.|.|.|||. ...
vnkaknryanilaydhtrvkLqmlegee..gsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kgs

KPYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINES-RHNTAPWIVHC
. ||. .| | ..  ..||..|.| ||      | . |  | . |||.| |||.|||. .. .| . ... .   .... | .|||
rsygklvvelkeevelsdyvlrefkvt......rteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC
subfamily_Ptp69D_pd Subfamily Ptp69D 2-186 7.8e-55 181.2 In-house 47-226 (307) alignment 
Range on Protein: 2-186
Range on HMM: 47-226/307.0
ENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTnQP
||..|||| .|...|.|||.||   |  .  |||||||...|.. . ||.||||.|||   .|||.|...    .||||. | | |..||.||||.  . 
enalknRyedikafDktRvkLkking..kedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.de

KPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
. ||.  | | ..|   ||. |.. |.   ..     |  | . |||.| |.|  ||. |...|.. ... .  ..| .| .|||
vqygdilvklvseekhsdyiiReldvskkkees.gevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhC
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-186 5.5e-54 178.2 In-house 48-219 (315) alignment 
Range on Protein: 2-186
Range on HMM: 48-219/315.0
ENKIKNRYGNIVTYDHTRVVLkgPGGNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTnqP
||| |||| ||..||..|| |  |  . |  |||.||....|..  ...|||||||   | .|||..|..| .. |||||.|.||.|.|. |||||    
enkqknryiniiaydksrvql..pllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..k

KPYGQYTVSLCKNEAFADYTVRTFlvtvrlqqQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
  ||..||.. ..| . .|||||.          | .. .| ..|.|.| ||| |||.|..... . ...      . .. .|||
viyGkitvtrkseevnteytvrtl........svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhc
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-186 2.4e-53 176.3 In-house 45-223 (305) alignment 
Range on Protein: 2-186
Range on HMM: 45-223/305.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP
.|| |||. .|...|. |. |.    .    ||||||||..|...  ||||.||||..   .|||.....|. |.|||||.|.||.|.||..|||.. . 
ankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskte

-KPYGQYTVSLCKNEAFADYTVRTFLVTVRLQqqrvgDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT-APWIVHC
 | .|...| |  .....||. | . .... .     |.  | . ||..| |||.||||.||..|.. |.. .. ...   | .|||
kkefgefsvelksektasdyieRklkisiede.....dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhC
subfamily_PTPRA_pd Subfamily PTPRA 2-186 5.6e-53 175.0 In-house 57-235 (330) alignment 
Range on Protein: 2-186
Range on HMM: 57-235/330.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQp
||| |||. ||. ||..||.|    |. .  |||||||...|.    .|.|||||| | . .|||.|.|. . . ||||| | | ..|||..||||    
enkeknrvvnilPydfsrvilsvkeGvee..sdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.

KPYGQYTVSLCKNEAFADYTVRTFLVTvRLQQqRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
  ||. .|.. ...   ||||| |||. .| .    ..  | . |.||| ||| |||  .  .|.. ||. .  . .. | .|||
vtyGnirvevedetvlvdytvrkflvq.qlpd.atrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhc
subfamily_PTPRK_pd Subfamily PTPRK 2-186 4e-50 165.4 In-house 42-217 (314) alignment 
Range on Protein: 2-186
Range on HMM: 42-217/314.0
ENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP
||. |||.|.|..||..||.|.   |  |  ||||||... ..   |...|..|||..    |||..|..|.|. ||||| |.|  . || ||||.  . 
enreknrsgdilaydrsrvflitidg..dpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

kpYGQYTVSLCKNEAFADYTVRTFLVTVrlqqQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
  ||.  | | . |. |.. ||.| |.        | |. | . |..|. ||| .||..||..|.. ... . . ..  . .|||
..ygdikvelvetellaelvvrifrvek....largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhC
subfamily_PTPN12_pd Subfamily PTPN12 2-186 5.8e-50 164.8 In-house 39-214 (290) alignment 
Range on Protein: 2-186
Range on HMM: 39-214/290.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP
||. |||| .|. ||..||.|.   ..    ||||||....| .| ...|||||||.    ||||.|.|. . ...||.  ..| .| ||..|||.... 
envkknrykDilPydksrvelskieeee..gsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee

KP-YGQYTVSLCKNEAFA-DYTVRTFLVTVRlqqqrvgdEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
.  .|...|.| ...|.  |...||. |...        .  | .||.|.| |||.|||. |. .|.. ... .  ... || .|||
elefgefevtleeekavdddflirtLkveaq........kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhC
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-186 2.2e-49 163.0 In-house 46-218 (287) alignment 
Range on Protein: 2-186
Range on HMM: 46-218/287.0
ENKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQp
.|| |||. .|. .|  ||.||      . . |||||....|.    |..|.|..|.     .||....... ..||||. . | ..|.|..|||...  
qnkdknRltqilvpdnyrvllk......gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.

KPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRVgdeglRFIYQYHFTVWPDKG-VPQYATAVLRFRKKIINESRHNTAPWIVHC
  .|.|...| ..|  |.|..|.. |. . ...       . . ||..| |...| |....| .| . ... .. ..  .. .|||
vvlGeyniellneevnagyierklevknknkagdk.....qqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhC
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-186 2.4e-48 159.6 In-house 43-217 (315) alignment 
Range on Protein: 2-186
Range on HMM: 43-217/315.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPD-TNQ
.|  ||||.||. .|..||.|.    . .  ||||||||....|   | |||.||| . | ||||.||.||. . |||.| . ||.| || .||||   .
infkknryknilPldsarvklevi..ddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

PKPYGQYTVSLCKNEAFADYTVRTFlVTvrlqqqRVGDEgLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
   .|.. |.| . || .| ..| . ||      | ..|  | . |..|| ||||||.. ....|.. |..  . .... . .|||
svefGsikvellsleadtdgvarkl.vt......rksee.srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhc
subfamily_PTPN9_pd Subfamily PTPN9 2-173 1.2e-45 150.8 In-house 41-204 (297) alignment 
Range on Protein: 2-173
Range on HMM: 41-204/297.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWP-DTNQ
 |  |||| ... ||.|||||.    . |  ||||||....|.   .| .||.|||..  ..|||.|||.... |||| | ..|  . || .||| ....
anleknrytdvlcydetrvvlakv..dedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

PKPYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN
 . .|...||  . |   ||.||.. ..      .| .|  | .  . |. ||| |||. |...| ...|. .
saefgdlsvsnveveeeedykvrvleik......nvkteesrkvthfqflsWPdyGvPssaaslldvlekvre
subfamily_PTPRN_pd Subfamily PTPRN 2-186 3.8e-43 142.3 In-house 55-231 (297) alignment 
Range on Protein: 2-186
Range on HMM: 55-231/297.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQp
.|  |||. ....|||.|| ||    . . .||||||| .   |     |||.|||.  .  |||||||.. . |||.|| | | . ..|..||||. . 
knvkknrskavlpydhsrvklkee..asaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGs.

KPYGQYTVSLCKNEAFA-DYTVRTFLVTvRLQQQRVgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
. |. | | |  .  .. || ||.| .   ||...      | . |.||  ||..|||  | ..| ||.|.    |  ..| .|||
evyhiyevhlvsehiwcddylvrsfylk.nlqtset.....rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhc
subfamily_PTPN13_pd Subfamily PTPN13 2-186 4.1e-40 132.8 In-house 36-209 (273) alignment 
Range on Protein: 2-186
Range on HMM: 36-209/273.0
ENKIKNRYGNIVTYDHTRVVLKGPGGnrdgrsdYINASYLQGFDG-TPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ
||| |||| |.. ||.||| |.. ||       |||||...   |    .|||.|||.  ...|||||||. ...||.|.|   |..| |||.|||....
enkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPeskn

P--KPYGQYTVSLCKNEAFADYTVRTFLVTvRLQQQRVgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRhNTAPWIVHC
   | .....|.| | .   ...||.. |.  .. ...     | . . .|. ||| |||. |. .|.| ... .  . ...| .|||
kklkvsnrlevellkvqkldgfvvralavk.dsesges.....revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhc
subfamily_CG7180_pd Subfamily CG7180 2-186 8.6e-38 124.6 In-house 41-230 (296) alignment 
Range on Protein: 2-186
Range on HMM: 41-230/296.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKeKCHKYWPDTNqP
||. |||. ..| ||..||||.  .|. .  ||||||.| ..|   .|.||  ..|.. . |.||..|..| .| .|.||   . .| ....||| .   
enreknrdvkvvPyDynRvvLekldGeek..sdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.k

KPYGQYTVSLCKNEAFADYTVRTFLVTVR----LQQQRVGDEGLRFIYQYHFTVWPD-KGVPQYATAVLRFRKKIIN---ES--RHNTAPWIVHC
. ||.  | . ... .|. . ||| .| .     .|..  .   | . ....|.|.  . ||  ..|.. .|...     .   . ...| .|..
eqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-186 7.9e-37 121.6 In-house 39-233 (301) alignment 
Range on Protein: 2-186
Range on HMM: 39-233/301.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN-Q
|||  ||. ||..||. |..||        . .||||||..|.    ||.||||||..    |||...|||. . |||.|.| || |.||..|||... .
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

PKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQ--------R-VGDEGLRFIYQYHFTVWPDKGV-PQYATAVLRFRKKIINESRHNTAPWIVHC
 . .|. || | .. .. |...| . |...   .        .   |   . . |.. | ||. || ....| .    . |. . . . .| .|||
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHC
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-186 8.7e-37 121.5 In-house 32-206 (283) alignment 
Range on Protein: 2-186
Range on HMM: 32-206/283.0
ENKIKNRYGNIVTYDHTRVVLKGPGGnrdgrsDYINASYLQ--GFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN
||| |||. .||..|  || ||          |||||...     .   ||||.||.|..    |||.||..|. . ||||| | |....|| .|||   
enkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

QpKPYGQYTVSLCKNEAFADYTVRTFLVTVRlqqqRVGDEGLRfIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
  . ||..||.| |. .   .... .|. |         . |  .  | .  | . |      ....| | | .  ... .| .|||
s.edyGeftvtlrkettsnsfiikelllrvn....ssakstll.lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhC
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2-186 1.3e-36 120.8 In-house 44-176 (392) alignment 
Range on Protein: 2-186
Range on HMM: 44-176/392.0
ENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNkekchkywpdtnqp
 |. ||||.||. || .||.|.    .    |||.||||...||   | |||.|||   | ||||.||.||. . |.|.| | ||.              
inlkknryknilpydsarvklevi..ddipdsdylnasyipsfdn.ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..............

kpygqytvslckneafadytvrtflvtvrlqqqrVGDEgLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
                                   ||.  | . |.||| ||||.||......|.| |..  .  . | | |.||
..................................kgdd.artvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihc
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-186 1.1e-74 245.6 In-house 8-181 (239) alignment 
Range on Protein: 3-186
Range on HMM: 8-181/239.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQpk
|| |||| |||||||.||||.    . | .|||||||||. .||.|| |||.|| ||.|. |||.|.||||  ||||||||||| |.|||.||||.    
nkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

PYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
 | .  |.| | | |||| .|||...      .||.   |..||||||||||||||||||||| .|.|| ..|   . ||..||
kycnlrvtlrktevfadyiirtfvms......qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihc
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3-186 1.1e-74 245.6 In-house 7-180 (239) alignment 
Range on Protein: 3-186
Range on HMM: 7-180/239.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQpk
|| |||| |||||||.||||.    . | .|||||||||. .||.|| |||.|| ||.|. |||.|.||||  ||||||||||| |.|||.||||.    
nkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..

PYGQYTVSLCKNEAFADYTVRTFLVTvrlqqqRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
 | .  |.| | | |||| .|||...      .||.   |..||||||||||||||||||||| .|.|| ..|   . ||..||
kycnlrvtlrktevfadyiirtfvms......qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihc
Y_phosphatase Protein-tyrosine phosphatase 3-186 1.4e-57 190.2 Pfam-A 1-177 (235) alignment 
Range on Protein: 3-186
Range on HMM: 1-177/235.0
NKIKNRYGNIVTYDHTRVVLkgpgGNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWP-DTNQP
|| |||| .|. ||.||| |     ...|.||||||.|..|.. ..||.||.|||.. ...|||.|||||...|||||| | | ..|||..||| .....
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

KPYGQYTVSLC-KNE-AFADYTVRTFLVTVRLQQQrvgdeGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
. ||...| |  |.. . ..||.|.. .. . ...       | ..|.|.| |||.|||. ....|.. .|. ........| .|||
ltygdikvelkekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhC
Y_phosphatase Protein-tyrosine phosphatase 3-186 1.4e-57 190.2 In-house 1-177 (235) alignment 
Range on Protein: 3-186
Range on HMM: 1-177/235.0
NKIKNRYGNIVTYDHTRVVLkgpgGNRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWP-DTNQP
|| |||| .|. ||.||| |     ...|.||||||.|..|.. ..||.||.|||.. ...|||.|||||...|||||| | | ..|||..||| .....
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

KPYGQYTVSLC-KNE-AFADYTVRTFLVTVRLQQQrvgdeGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
. ||...| |  |.. . ..||.|.. .. . ...       | ..|.|.| |||.|||. ....|.. .|. ........| .|||
ltygdikvelkekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhC
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-186 4.7e-50 165.1 In-house 43-216 (515) alignment 
Range on Protein: 3-186
Range on HMM: 43-216/515.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPD-TNQP
|  ||||.||. || .|| |.    | .  |||.||||...||   | |||.||| . | ||||..|.||. . |.|.| | ||.| || |||||   . 
nfkknryknilPydsvrvklevi..ndnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

KPYGQYTVSLCKNEAFADYTVRTFLVTvRlqqqrvGDEgLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
  .|.. |.|   || .. . |.. |. .      ||.  | . |.||| |||||||. ....|.. |..  .  . | | |.||
vkfGsikvelvsleactggikrkltvl.k......gdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihc
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3-186 4.4e-47 155.5 In-house 28-208 (274) alignment 
Range on Protein: 3-186
Range on HMM: 28-208/274.0
NKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP-
.. |||| .|.  ...||.|.   .. |  |.|||| |..|.|.. | |.|.|||.    .|||.|..||...|||||| | | |..||..|.||...  
sqtknryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

--KPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRvgdeglrfIYQYHFTVWPDKGVPQYATAVLRFRKKIIN---ESRHNTAPWIVHC
  . ||.  .   |     ||.||....    ....        .. | .| |||. .|. |...|.. ... .   |. ...|| .|||
iserygdveikvekiverndysvrklvlkylerers........vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhC
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 3-186 4.7e-41 135.6 In-house 20-204 (270) alignment 
Range on Protein: 3-186
Range on HMM: 20-204/270.0
NKIKNRYGNIVTYDHTRVVLkgPGGNRDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtnQPK
.|  ||| .|.   .|||.|  .  . | .. |||| |..|||| .||||||.||.. .  .||.|.|.|. . |||.||| | ...|| .|||   .||
gkklnRyadiLPsPatRvrl..eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa..epk

PYGQYTVSLCKNEAFADYTVRtFLVTVRLQQQRVGDEgLRFIyQYHFTVWPDKGVPQYAT------AVLRFRKKI---INESRHNTaPWIVHC
   ...    |  | ..   . . .. ||. .. |.|  | .  .... |||.|||. .        .|.  ...    .| .... |..|||
ekvkledgkikvlalseekee.gyiltrlrleekgee.rrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHc
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 3-186 5.5e-32 106.0 In-house 41-216 (307) alignment 
Range on Protein: 3-186
Range on HMM: 41-216/307.0
NKIKNRYGNIVTYDHTRVVLKGPGGNrdgrSDYINASYLqGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDT-NQP
|  |||| ..   |..|.|.| .|      |||| | || |    |||.|.|||| | .  .|| |. ||.   ..||  .||  | ||..|||    | 
ntdknryqdvkcqdkgrivvkfdgla....sdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

KPYGQYTVSLCKNEA-FADYTVRTFLVTVRLQQQrVGDEGLRFIYQYHFTVWPDKGVPQYATAVLrfrkKIINESRHNTAPWIVHC
. .|. . ... ..      .    |. |   .  .  .. | | .. .. |||.||||   . .     ...  | .| | .|||
lvfgeapntisvanlgakklapdedlinvttlkv.dwaqksrtiqhlqwenwpdrgvpqinltai....nlleavrydtnpvvvhc
subfamily_ptpA1_pd Subfamily ptpA1 3-186 2.7e-31 103.8 In-house 47-236 (418) alignment 
Range on Protein: 3-186
Range on HMM: 47-236/418.0
NKIKNRYGNIVTYDHTRVVLKGPGgNRDGrSDYINASYLQGfdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPK
|  |||| ||.  .|||| ||    ...| |||||| |..|    ||..|..|||.  .  |||.|||..|| .||||.   |  . || .|||.    .
ntsknrytnilpvnhtrvqlkkiq.dkeg.sdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

pygQYTVSLCKNEAFADYTVRTFLVTVR------LQQQRVGDEG-LRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN------ESRHNTAPWIVHC
   |...    || |  |.|    |          .. |.  ||  | | ||..  |||. .|...  . .. . | |       |     | ||||
...qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc
0041856 (Phosphotyrosine protein) phosphatases II 3-186 3.6e-28 93.8 In-house 1-116 (182) alignment 
Range on Protein: 3-186
Range on HMM: 1-116/182.0
NKIKNRYGNIVTYDHTRvvlkgpggnrdgRSDYINASYLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTgliegnkekCHKYWPdtnqpk
|. |||| .|. |||.|             .|||||... |   . . .||.|||   .. ||..|........||.||         .. |||      
nldknrysdilpydhsr............dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp......

pygqytvslckneafadytvrtflvtvrlqqqrvgDEGLRFIYQYHFTVWPDKGVPQyATAVLRFRKKIINesrhNTAPWIVHC
                                   ..  | ..||... ||| |||     .|.| .....    .  | .|||
...................................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHC
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 3-186 2.8e-26 87.0 In-house 48-226 (305) alignment 
Range on Protein: 3-186
Range on HMM: 48-226/305.0
NKIKNRYGNIVTYDHTRVVLKGPGGnrdgrSDYINASYLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPK
.. |||| ..   |. || |.||        .|| | |.      ||..| .| |.| .| ||| | .|..   | ||  |.|   .||..|..  ....
eagknrykdvgcldnnrvklegpwp.....heyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

P----YGQYTVslCKNEAFADYTVRTF----LVTVRLQQQRVGDEgLRFIYQYHFTVWPDKGVPQYATAVLRfrkkIINESRHNTAPWIVHC
      ||  .   | |. . .  |.     .    |  .  | .  | . .||.  |||.|||   .|.|     .....|    | .|||
lefeekgqkis..vkfessvtlkfrkdakakvtetvlviegpgek.arkvthyhwidwpdrgvpaadlaile....llekarpskgpivvhc
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 3-186 2.2e-20 67.9 In-house 43-211 (288) alignment 
Range on Protein: 3-186
Range on HMM: 43-211/288.0
NKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASYLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ-P
|  ..|| |.   | ||| |.      |    ||.|  .      ... | || |..   . .|.|. ..    ||||. |.|  |||  .|.|      
nptrdryenlprcditrvkls......ddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

KPYGQYtVSLCKNEAfadYTVRTFLVTVRLQQQRVGDEGLrFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHC
  .|..  .  |..      .   ..   |. ...|.|   .. . |.  |.|.|||.   . ||. . .    .  . | .||.
arigrl.ctvvkkkr...adidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevl....kslqkPivvhs
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 3-128 8.6e-20 65.8 In-house 33-149 (267) alignment 
Range on Protein: 3-128
Range on HMM: 33-149/267.0
NKIKNRYGNIVTYDHTRVVLkgpggnRDGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHkyWPDTNQPK
|. .||. . . ||.|||.|      |.   .||||||..|.  | ...|. |.|.. .  ||.... .....|||.||   ..|  . .   |   | |
nqernrlddnlpyddtrvil......rtkeeeyinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfw..PPkmgqak

PYGQYTVSLCKNEAFADYTVRTFLVT
 | . ||  . ..   || . |. . 
kyqdltvehslekeendyqiitlelk
subfamily_egg_pd Subfamily egg 3-120 1.2e-19 65.1 In-house 40-155 (307) alignment 
Range on Protein: 3-120
Range on HMM: 40-155/307.0
NKIKNRYGNIVTYDHTRVVLKGPGGNRDGrsDYINASYLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGnkEKCHKYWPDTN-QP
|. | |   .   | .|| |. . |   .  |.| | ...| .    ..| || |.  . ||||.||.||..  |||||   |   |.|. ||| .. ..
nlekarskrvhckdssrvklelrrGqyld..dfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

KPY--GQYTVSLCKNEAFADY
  .  | . .   | .  || 
lvtvpGslrienlkvdskadp
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 3-161 3.6e-10 33.9 In-house 47-190 (303) alignment 
Range on Protein: 3-161
Range on HMM: 47-190/303.0
NKIKNRYGNIVTYDHTRVVLKgpggnrDgrSDYINASYLQgFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPK
|  |||. ...  ||..| |       |  | || ||||. .| . || | .| |.  .. |||||. ...  ....|    | .|   .  .|  ..  
nmdknrfvdvicldhskvkls......d..ssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

PYGQYTVslcKNEAFADYTVRTFLVtVRLQQQRVGDEgLRFIYQYHFTVWPDKGVPQYA
 . . ..   .   |    .    | ...     ||    |.. .|.  || . .|  .
kfeersi...rvgefkrvelgdgwv.lkvlsvsngdy.ksflhvhhykawphnsipsdg
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 3-174 9.3e-10 32.4 In-house 51-213 (302) alignment 
Range on Protein: 3-174
Range on HMM: 51-213/302.0
NKIKNRYGNIVTYDHTRVVLKGpggnrdGRSDYINASYLQGFDGTpKKYIAAQGPVEPSC---DDFWQMVWQERCSVIVMLTGLIEGNKeKCHKYWP-DT
|  ||.  ..  .|...| |..         .|.||| ..  . | .. | || |.  |    ..||.||.||..  .|.| |  | .|   ....|  .
nlkknqsedvpildsnlvklea......epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

NQPKPYGQYTVSLCKNEAFADYTvRTFLVTVrlQQQRVGDEGLRFIyqYHFTVWPDKGVPQYATAVLRFRKKIINE
.. | ||.  |   | |   . .   . . |    . . .  |  .  |..| |..| ||.  ... .  .|. ..
gdykeygkmfvNnrkVekaeeek.tryviEv..lPegcsnsvlanv..yvltnWkqkkvpvkyaeliktaakvfak
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3-56 7.3e-09 29.7 In-house 48-95 (95) alignment 
Range on Protein: 3-56
Range on HMM: 48-95/95.0
NKIKNRYGNIVTYDHTRVVLKgpgGNRDgrSDYINASYLQGFDGtPKKYIAAQG
|  |||. ||. || |||||     .||  |||||| ...|.    . ||||||
nipknrflnifpydatrvvlt...tkrd..sdyinacfvdgyar.kncyiaaqg
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 3-164 1.8e-08 27.4 In-house 26-160 (169) alignment 
Range on Protein: 3-164
Range on HMM: 26-160/169.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINAsylqgfdgtpkkyiaaqgpvepscddfwQMVWQERCSVIVMLtglieGNKEKCHKYWPDTN--Q
|. |||    ..  |||| |.      |  ||||||                            .|.|.   ||||.|     |. .    .||. .  |
netknrpagplapshtrvklqrv..medlgsdyina............................rmiwetnasvivvl.....Gdtddknnfwpekedyq

PKPY---G-QYTVSLC-KNEAFA-DYTVRTFLVTVRLQQQRVGDEGLRFIYQYHFTVWPDKGVPQYATAV
 .|    |  || ||  . . .  . .    |. | |  ..  |.  . .  .|...||..||||    |
lhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhv
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 3-164 2.8e-08 26.9 In-house 27-161 (169) alignment 
Range on Protein: 3-164
Range on HMM: 27-161/169.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINAsylqgfdgtpkkyiaaqgpvepscddfwQMVWQERCSVIVMLtglieGNKEKCHKYWPDTN--Q
|. |||    ..  |||| |.      |  ||||||                            .|.|.   ||||.|     |. .    .||. .  |
netknrpagplapshtrvklqrv..medlgsdyina............................rmiwetnasvivvl.....gdtddknnfwpekedyq

PKPY---G-QYTVSLC-KNEAFADYTVR-TFLVTVRLQQQRVGDEGLRFIYQYHFTVWPDKGVPQYATAV
 .|    |  || ||  . . .   |     |. | .  ..  |.    .  .|...||..||||    |
lhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhv
subfamily_PTPN23_pd Subfamily PTPN23 4-186 1.5e-44 147.0 In-house 44-219 (288) alignment 
Range on Protein: 4-186
Range on HMM: 44-219/288.0
KIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPD-TNQPK
  |||. .|. |||.||.|.      ... ||||||....   .  ..||.|.| ...  |||.||.... ||||||.   | .|.|...|||  .....
seknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

PYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQrVgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN----ESRHNTAPWIVHC
 .|...|.| ...    .  |.. .... ... |     . .   ..| ||. |||.    .|.| ... .    . |.  .| .|||
kfgdlsvtlksvretethvervlkletldada.v.....ksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhC
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 4-186 1.7e-40 134.0 In-house 49-224 (297) alignment 
Range on Protein: 4-186
Range on HMM: 49-224/297.0
K---IKNRYGNIVTYDHTRVVLKGpgGNRDGRSDYINASYLQGFDGtpkKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKeKCHKYWPDTNQ
|    |.|| ||. ||  || |.    | |  |||.|||...|.     ..|. | | . . .|||.||..|. |.||||. . |..| || .||.|.  
kvnfeksRYkniLPydssRvkLai..vnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

pKPYGQYTVSLCKNEAFADYTVRTFLVTVRLQQQRvgdeglRFIYQYHFTVWPDKGVPQ--YATAVLRFRKKIINESRHNTA-PWIVHC
 ...|. .| |   .    .  |.. ||    ..|      |.. ||.|. |||| |..   |...| . . . ..  .|.  | .|||
.ttfGdvsvvllsvsereGfikrelevtkgkakar......rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhc
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4-186 6.7e-40 131.9 In-house 49-219 (439) alignment 
Range on Protein: 4-186
Range on HMM: 49-219/439.0
KIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKekchkYWPDTNQpKP
. |||| .....|||||.|.   |     | |||| |..|.  ..| |||.||| . ..||||..|...... ||||| |.|  |     |||  ..   
qtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.vc

YGQYTVSLCKNEAFADYTVRTFLVTvrlqQQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKI-INESRHNTAPWIVHC
||. .|   .|  . .|..| | |     ..|   |  | . |.|.. |||| ||  |. || | . |   . .... | .|||
ygdiavrvdrnielpnyvirgfkvf....nerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhc
subfamily_CG42327_pd Subfamily CG42327 4-166 3e-29 96.7 In-house 29-185 (319) alignment 
Range on Protein: 4-166
Range on HMM: 29-185/319.0
KIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN---Q
| |.|. |.|   .|||||.  |   | .. |..|||..|.| .|  ||||| . | |  |||..||. .  ||| || | |   ..| .|.|  .   .
kdksrvinvvPlPetrvvlqrig..dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

PKPYGQYTVSLCKNEAFADYTVRTFLVtvrlqqQRVGDEGLRFIYQYHFtVWPDKGVPQYATAVLR
 . ||.. |.| ..|.   | . |.|.      .|| .|  | .  | .  |.. .||   .|.. 
tslyGdilvtlkgrevkdryaistlll......krvdkeesrelthywy.kwleaevPaeeaalia
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 4-186 1.1e-22 75.0 In-house 53-230 (310) alignment 
Range on Protein: 4-186
Range on HMM: 53-230/310.0
KIKNRYGNIVTYDHTRVVLKGpggNRDGRSDYINASYLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKP
  |||| ..|  | .|| ||    ..    ||| | |..  .   . .| .|||.. .  |||.|..|||.  |..|    |  . ||  |||     . 
mhknrysdvvcldtsrvklki...dksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGQYTVSLCkNEAFADYTVRTFLV-----TVRLQQQRVGDEGLRFiYQYHFTVWPDKGVPQYATAVLrfRKKIINESRHntAPWIVHC
||   |.   .|.  .. .  . |      | ...|    ..||     ..  |||.|||.     .   .... . ||   | .|||
ygcirvtnl.sesseefeicnlavtfvpdnvpvdeqpanlkelrv.slikwpnwpdrgvpdekchtv..pqrllaqvrh..gpcvvhc
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 4-186 3.2e-22 73.5 In-house 56-228 (305) alignment 
Range on Protein: 4-186
Range on HMM: 56-228/305.0
KIKNRYGNIVTYDHTRVVLKGPGgnrdgRSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKP
. |||| ..   |.. | |. |       |||| | |.       |..|.||||.. . |.|| || |..   ||||   .|  | || .||| ..  | 
itknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

YGQYTVsLCKNEAFADYTVRTFLVTVRLQQ-QRVGDEGLRfIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHC
  .  . . .| . .    |   . . | .    ||. .  . . ..| |||.|||    . | .   |    |    | .|||
elksgi.vvenvsgskpmerdaeiqitllnltysgdqkms.vrhlqwtewpdrgvppckltslellsai....rgskvpivvhc
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 4-111 2.4e-16 54.0 In-house 49-165 (349) alignment 
Range on Protein: 4-111
Range on HMM: 49-165/349.0
KIKNRYGNIVTYDHTRVVLKG----PGGNRDG--------RSDYINASYLQGFDGT-PKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEK
  |||| .|. |.|.||.||     . . .            ||||| ||.    .  ||||| | |.  . |||....  ..  ... |.   | . ||
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHKYWPDTNqpkpYGQYTVSL
|..|| . .    | ..|| |
cdiywqels....ysnitvkl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 5-186 3e-38 126.3 In-house 40-217 (287) alignment 
Range on Protein: 5-186
Range on HMM: 40-217/287.0
IKNRYGNIVTYDHTRVVLKGPGgnrDGRSDYINASYLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKPY
 ||||.... .|.|||.|   |   .  |||||| |. ..    ...||||||.  .  |||..|...| ......|  .|  . ||.||||. ..|   
kknryadvlPiddtrvllsaeg...elGsdyinanyvasytd.deafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

GQYTVSLCKN-EAFADYTVRTFLVTvRLQqqrvgDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKI---INE--SRHNTAPWIVHC
| |.| | .      .|.||.. .   |.      .  | . |...  ||||...  | ...||  ..   |.   .  .. | .||.
GGysvvlldydikePeygvralrli.dle.....trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 5-186 2.2e-32 106.9 In-house 58-223 (290) alignment 
Range on Protein: 5-186
Range on HMM: 58-223/290.0
IKNRYGNIVTYDHTRVVLKGpGgnrdGRSDYINASYLQGfdgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN-QPKP
 |||| ..|  | |||.||  |    .  ||. | |..|   .   .| .||... .  |.|.|| ||. ..||||  |||  | ||..|.|... .   
kknrykdvvcndktrvilkd.G....ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGQYTVsLCKNEAFADYTVRTFLVTVRlqQQRVGDEglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHC
.|..|| || .|   |  .   ...||  ..  | |    .. ..   |||| |.. . |.||  . .    |. . | .|||
fGeitv.lcseeddkdaniikktlsvr..dkdsGke..hklkhlkikswpdksvalstlallrtlril....rkasGpvvvhc
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 5-172 2.8e-32 106.8 In-house 35-194 (297) alignment 
Range on Protein: 5-172
Range on HMM: 35-194/297.0
IKNRYGNIVTYDHTRVVLKGPGGNrdgrSDYINASYLQGFD-GTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKP
 |||| .|...| ||| |..   .    .||||| |.   |  .. ||| ||||.. . ||||..|...   ||||.. | |. ..||  |||...| . 
rknryrdilatddtrvkllrvite....rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

YG-QYTVSLCkNEAFADYTvRTFLVTVRLQQQrvgdEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKII
   .. |     .   ..  | .|  ..|  .    .  | .    |  |||.|||     . ||. ...
kagdvvvefl.sstsdefd.rviltelqliyr....sesrvvrhvqflswpdhGvpsdledlvrfqaqvc
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 5-100 1.3e-25 84.9 In-house 49-155 (350) alignment 
Range on Protein: 5-100
Range on HMM: 49-155/350.0
IKNRYGNIVTYDHTRVVLK----GPGGNRD--GRSDYINASYLQGF----DGTPK-KYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHK
 |||| ||. |.|.|| ||     . . .     .|||||.||.      .  |. ||||.|.|.    |||.... .    ||..|| ..| | |||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDTNQ
||.. . 
YWqegsy
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 5-80 1.6e-10 35.0 In-house 39-116 (347) alignment 
Range on Protein: 5-80
Range on HMM: 39-116/347.0
IKNRYGNIVTYDHTRVVLKgPGGNRDGRSD----YINASYLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVML
 |||  .    | |||||  |   . .|.|    |||||... || . |.|| .| |.  .  |||.||   . . .| .
sknrskdvklidatrvvls.peksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 6-186 4.1e-24 80.0 In-house 38-210 (285) alignment 
Range on Protein: 6-186
Range on HMM: 38-210/285.0
KNRYGNIVTYDHTRVVLKgpggNRDgrSDYINASYLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN-QPKPY
 ||| ..   . ||||||    |.|   ||| ||...        ||..|||.  .  |||.|..||. . ..||  |.||  |||  |.|.   .   .
lnryadvrcieetrvvlk....nhd..rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GQYTVSL--CKNEAFADYTVRTFLVTvrlQQQRVGDEGLrFIYQYHFTVWPDKGVPQYATAVLRFRKKiINESRHNTAPWIVHC
|.| ..|  ||.|| |   . .. |.   . .    | | .. . .   |||.  |. |  .. . |  ...   .  |  |||
gkyeitlteckeeaiagtilnaltvi...ntedassepl.ymnhvqvpwwpdqlapedarpmielykw.vkkvnpkekpicvhc
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 6-186 3.6e-17 57.0 In-house 46-216 (312) alignment 
Range on Protein: 6-186
Range on HMM: 46-216/312.0
KNRYGNIVTYDHTRVVLKGpggnrDgRSDYINASYLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQ---PK
 ||| ||  .|  |  | |     |    || | ...     |......|||.| .|  |||..    .. |..|.|..|   ||| ||  |       .
lnrypniqcwdrgrftlag.....d.enfyihanfvk.ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

PYGQYTVSLCKNEAFA----DYTVRTFLVTVRlqqqRVGDEGLrfIYQYHFTVWPDKGVPQYATAVLRFrkkiINESRHNTAPWIVHC
 .  || .  . |         | | . | |.      |.|    . .| .. |||.|.|.   . ||.    .   ...  | | ||
dhrvyteycteieiggkskdkithrvlkvvvk....atgqesk..lnhyqwaswpdhgmpdscdtalrl....lsavkkdkkpviahc
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 6-90 2.8e-09 30.9 In-house 37-117 (332) alignment 
Range on Protein: 6-90
Range on HMM: 37-117/332.0
KNRYGNIVTYDHTRVVLKgpggNRDGRSDYINASYLQGFDGTpKKYIAAQGPVEPSCDD-FWQMVWQERCSVIVMLTGLIEGNKEK
 ||   .  .||.|| |      .||. |. |||...|.      || || |..   .  ||.|| . . |.|...  . | .| |
mnriphlycfdhsrvela....pqdgkddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_eak_pd Subfamily eak 9-169 1.9e-18 60.9 In-house 57-205 (332) alignment 
Range on Protein: 9-169
Range on HMM: 57-205/332.0
YGNIVTYDHTRVVLKGPGGNRDGrsdYINASyLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTN-QPKPYGQY
  .|| ||.  | |     ||.|   ||||| |  |    .||| .  . |     ||||| ...   ||.|   .| . ||  ||.||   .   .|..
vvkivpydrylvrltssqlnrlG...yinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

TVSlCKneafaDYtVRTFLVTVRLQQQRVGDEGLRfIYQYHFTVWPDKGVPQYATaVLRFRK
 |  .|     .. |.   . .|| . ..|.|  | .. |..  | .  .|.|    | .||
dve.rk.....ef.vkrniletrllelskGnethr.vlhykvfGwtettlpkyed.flalrk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 14-186 1.6e-11 38.9 In-house 29-198 (290) alignment 
Range on Protein: 14-186
Range on HMM: 29-198/290.0
TYDHTRVVLKGPGGNrdGRSDYINASYLQGFDGTpkKYIAAQGPVEPS-------CDDFWQMVWQERCSVIVMLTGLIEGNKE----KCHKYWPDTNQ-P
   .||||||| |      .||| |....  .|   . |. | | |           .|| |. ||.   .|||    | ...     | || |..    
LveatrvvLkgygkr..fnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee

KPYGQYTVSLCKNEAFADYTVRTFLVTVrlqqqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHC
  ..  ||. .. |.  |  .|. .|.        .||    .  . .  | .  |..    .|   .|.    . ...| ||||
lkfkgltvkCkskekeddvetRelvvkf.......ddeeeftvtHsllkgWnklnvqedtktllsliqkv....kasktpvivHc
0044763 (Phosphotyrosine protein) phosphatases II 15-186 3.7e-18 61.2 In-house 2-117 (178) alignment 
Range on Protein: 15-186
Range on HMM: 2-117/178.0
YDHTRVVLKGPggNRDGRSDYINASYLQGFdgtpkKYIAAQGPvepscDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQpkpygqytvslckn
.|.|||.|  .   .  ||||||||.  ..      |.....|      |........ ...||.||. .|....||..|||. .               
ldrtrvllsnl..eglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............

eafadytvrtflvtvrlqqqrvgdeglrfiYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
                              .||... .|| |||.    .|.| . | .    .  | .|||
..............................iqylhipipDhgvpdllehflefvefieealdekggpvlVHC
0046846 (Phosphotyrosine protein) phosphatases II 30-186 2.8e-23 78.0 In-house 9-116 (176) alignment 
Range on Protein: 30-186
Range on HMM: 9-116/176.0
DGRSDYINASYLQGFdgtpkKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKPygqytvslckneafadytvrtflvtv
|. .|||||... |      ..|| |||.. .. ||..|.........|.|| ..| .. ||. |||.  ...                           
dldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

rlqqqrvgdeglrfiyQYHFTVWPDKGVPQYaTAVLRFRKKIINESRHNtAPWIVHC
                ||... ||| |||.. ...|.. . | .  ...  | .|||
................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHC
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 30-186 4.7e-21 69.8 In-house 72-221 (301) alignment 
Range on Protein: 30-186
Range on HMM: 72-221/301.0
DGRSDYINASYLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPD-TNQPKPYGQYTVSLCKNEAFADYTVRTFLVT
||.   | | ...   | |...||.|||.. ...||| |. |     ||||.  .| ..|||..| |  ...    |.... . ..|   .  .    . 
dGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtle

VRLQQqrvGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRkKIINESrhnTAPWIVHC
|.      |.   | .  | .. |.|.|||.  . .  .  ... .|     | .|||
vedst...gkfatrtvthyqysewtdrgvPkshaelfdlm.elvkks...ekPivvhc
0043147 (Phosphotyrosine protein) phosphatases II 30-186 6.4e-21 70.3 In-house 2-107 (172) alignment 
Range on Protein: 30-186
Range on HMM: 2-107/172.0
DGRSDYINASYLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLiegnkekchkywpdtnqpkpygqytvslckneafadytvrtflvtv
|..||||||||| .    |...|| |||    ..|||.|.... ...||.||.|                                              
degsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel..............................................

rlqqQRVGDEGLRFIYQYHFTVWPDKGVPqYATAVLRFRKKIIN-ESRHNTAPWIVHC
    .  ..   |...||... ||| |||  .  .|.| . | .   . .  | .|||
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHC
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 32-119 6.7e-09 30.1 In-house 12-94 (130) alignment 
Range on Protein: 32-119
Range on HMM: 12-94/130.0
RSDYINASYLqGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLtglieGNKEKCHKYWPDTNQPKPYG-QYTVSLCKNEAFAD
  .|||||.. |  |  ..|. .| |.  .. |||.|. .    |.|.|     |  |.  .||||..  . |  . .|.| . . |  
gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.....gsveeedeywpdsePlewyeediivtltdrdefkn
0051429 (Phosphotyrosine protein) phosphatases II 33-186 1.8e-31 105.2 In-house 4-157 (272) alignment 
Range on Protein: 33-186
Range on HMM: 4-157/272.0
SDYINASYLQGFdGT---PKKYIAAQGPVEPSCDDFWQMvWQERCSVIVMLTGLIEGNKEKCHKYWP-----------DTNQPKPYGQYTVSLCKNEAFA
|.||||... |. |    |.......|| . ...|||.. .......||.|... | ...||..|||           |. ..  ||...| | . | . 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYTVRTFLVTVRLQQQRVgdeglRFIYQYHFTVWPDKGVPQYAtaVLRFRKKIINesrhnTAPWIVHC
||..|..|.|  |. . .     | ....|.| ||| |||| |  .|.. . . .       | .|||
dyilrellltlllsagea.....revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHC
0036282 (Phosphotyrosine protein) phosphatases II 33-186 9.2e-24 79.5 In-house 2-111 (174) alignment 
Range on Protein: 33-186
Range on HMM: 2-111/174.0
SDYINASYLQGFDGTPkKYIAAQGPVEpscddFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDtnqpkpygqytvslckneafadytvrtflvtvrlq
|||||||.| ..  || ..|| ||| .     ||.|.........|||. ..| ...||. |||.                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

qqrVGDEGLRFIYQYHFTVWPDKGVPQYATaVLRFRKKIINESRH-NTAPWIVHC
     .   |...||... ||| |||  .. .|.| | . .   . .  | .|||
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC
0051082 (Phosphotyrosine protein) phosphatases II 33-186 2.6e-19 64.8 In-house 3-99 (151) alignment 
Range on Protein: 33-186
Range on HMM: 3-99/151.0
SDYINASYLQGFdgtpkkYIAAQGPVEpscdDFWQMVWQERCSVIVMLTGLIEGNkeKCHKYWPDTNqpkpygqytvslckneafadytvrtflvtvrlq
|||||.||. |.      ... .|| .    ||....... ...||.|... | .  .|..|.|...                                 
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qqrvgdeglRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINesrHNTAPWIVHC
         . ....... ||| |.|..  |||.| .....   ..  | .|||
.........ievlhipildwpdpglplsfdavleflellld...kkngpvlvHC
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 43-125 4.7e-10 33.4 In-house 228-309 (440) alignment 
Range on Protein: 43-125
Range on HMM: 228-309/440.0
GFDGTPKK--YIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLiegNKEKCHKYWPDTNQPKPYGQYTVSLCKNEAFADYTVRTF
 |.|  ||  .||.| |.. .  |||..| . | | |.||  |   |   |  |||   .   .| .||     | .    |||.
efegyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 44-167 5.9e-14 46.2 In-house 83-213 (302) alignment 
Range on Protein: 44-167
Range on HMM: 83-213/302.0
FDGTPKKYIAAQGPVEP---SCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQP-KPYGQYTVSLCK-NEAFADYTVR--TFLVTVRLQQQRV
 ||| ||   .. |. |   ... .| .. | . ...| |....|....|| .|. |  .    .|.|||   . .. ....| .    | || .. ...
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

GDEGLRFIYQYHFTVWPDKGVPQYATAVLRF
 ..  . .   .|. |||.| |. | . |  
kkkvkktvdilafsawpdhGapkeaytaldi
0049260 (Phosphotyrosine protein) phosphatases II 47-186 1.2e-20 69.2 In-house 7-96 (152) alignment 
Range on Protein: 47-186
Range on HMM: 7-96/152.0
TPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWpdtnqpkpygqytvslckneafadytvrtflvtvrlqqqrvgdeglrfiyQ
 |...||.||| . ...|||.|...  ...||||| | | .|.||..|.                                                  |
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................q

YHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHC
|... ||| |||. .  .| . . |    ...  | .|||
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHC
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 49-186 8.5e-16 52.7 In-house 5-142 (199) alignment 
Range on Protein: 49-186
Range on HMM: 5-142/199.0
KKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLiEGNKE-KCHKYWPDTNQP-KPYGQYTVSLCKNEAFADYTVRTFLVTvrlqQQRVGDEGLRFIYQ
..|||.| |.  .  |||||||.     |||.    . |||     ||| |.     ||  .|.     . .|||. ....|    ..       | | .
rryiatqhplretmadfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitalilt....nnttappstreish

YHFTVWPDKGVPQYATA---VLRFRKKIINESRHNTAPWIVHC
| || | .|  |. |     |.  |.   .  . . || ||||
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhc
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 49-186 8.8e-16 52.7 In-house 4-141 (198) alignment 
Range on Protein: 49-186
Range on HMM: 4-141/198.0
KKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLiEGNKE-KCHKYWPDTNQP-KPYGQYTVSLCKNEAFADYTVRTFLVTvrlqQQRVGDEGLRFIYQ
..|||.| |.  .  |||||||.     |||.    . |||     ||| |.     ||  .|.     . .|||. ....|    ..       | | .
rryiatqhplretladfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitalilt....nnttappstreish

YHFTVWPDKGVPQYATA---VLRFRKKIINESRHNTAPWIVHC
| || | .|  |. |     |.  |.   .  . . || ||||
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhc
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 61-186 1.1e-14 49.1 In-house 40-155 (255) alignment 
Range on Protein: 61-186
Range on HMM: 40-155/255.0
SCDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKPYgQYTVSLCKNEAFADYTVRTFLVTVRLQQQRVGDEglrfIYQYHFTVWPDKGVPQY
. | |.|.. | . .|.|||. . | ..|||..|.|   . |      |...  .. ||  .||  .|  | ...  ..    .  |... |..|  |. 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklk.ladvnvtttkssadvvlrtleitstlgekkktht....vkhysykGWieknaPel

ATAVLRFRKkIINESRhntaPWIVHC
|  .|   | .. .|.    . .|||
areilnilk.vvrdsk....svvvhC
subfamily_hpo-7_pd Subfamily hpo-7 62-168 9.7e-12 39.3 In-house 47-148 (263) alignment 
Range on Protein: 62-168
Range on HMM: 47-148/263.0
CDDFWQMVWQERCSVIVMLTGLIEGNKEKCHKYWPDTNQPKPyGQYTVSLCKNEAFADYTVRTFLVTVRLQQqRVGdegLRFIYQYHFTVWPDKGVPQYA
 | |.|.. | . .|.|||.   | ..||| .|.|     |      |..|  ..  |  ..|  ..  |.. .     .. . .| .. |..|  |. |
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekq.klanvnvcttkvqsdvllktlellstlge.Kkk...thtvkhysykgWiekndpela

TAVLRFR
  .|.  
reilnil
0048076 (Phosphotyrosine protein) phosphatases II 94-186 3.8e-07 25.4 In-house 2-88 (145) alignment 
Range on Protein: 94-186
Range on HMM: 2-88/145.0
YWPDTNQPKPYGQYTVSLCKNEAFADYTVRTFLVTvrlqqQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNtAPWIVHC
|||.   |. |     . .. | ..|. ..| |        .  .   |...||... ||| |||. .  .|.| . | .  ...  | .|||
ywpseilpglylgslptaldlellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHC
0048179 (Phosphotyrosine protein) phosphatases II 95-186 2.1e-07 26.3 In-house 3-90 (144) alignment 
Range on Protein: 95-186
Range on HMM: 3-90/144.0
WPDTNQPKPYGQYTVSLCKNEAFADYTVRTflvTVRLQQQRVGDEGLRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRhNTAPWIVHC
.|.   |. |     .... | .... ..|    ..|. ..  ..  |...||... ||| |||.... .|.| . | .  . .  | .|||
npseilpglylgslptaldlellkklgitt...vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHC
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 142-186 5.9e-07 23.2 In-house 89-134 (440) alignment 
Range on Protein: 142-186
Range on HMM: 89-134/440.0
RFIYQYHFTVWPDKGVPQYATAVLRFRKKiINESRHN--TAPWIVHC
| . |||.  |||||||..|  ||.. .  .|||...   .| .|||
rtlkqyhyqgwpdkgvpkfagpvlkmiqd.vnesqekagngpllvhc
PTPc_DSPc_SM00012 144-186 3.1e-08 29.1 In-house 2-46 (105) alignment 
Range on Protein: 144-186
Range on HMM: 2-46/105.0
IYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT--APWIVHC
...||.| |||.|||......|.. ... .. ....  .| .|||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhC