Gene NvecPTP-sf5-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP063_AA protein Get Run
NvecP063_AA_4-281 phosphatase_domain Get Run
NvecP063_AA_293-570 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-316 7.3e-163 536.1 In-house 4-319 (319) alignment 
Range on Protein: 1-316
Range on HMM: 4-319/319.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
.|.|..|.|......|||......||.......|...|.. |||||.|||||||.| |.|||..|||||..|||||||.|||||..|.||||||.|..||
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVESpaREIVQYHYTAWPDHGVPTHATSLL
..||||||||...|..||.|..||..|.|..||||..|.||||||.||..|||||..|.|||.......|.||.  ||.....||.||||.||..|||||
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevet..RevkhfqyteWpdhdvPekatsll

AFIRRIRNSVSR-DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKA
....|||.|... ..||||||||||||||||.|||||||.....||..|.| .||..|.|||.|||...||.||..||.||...|.||..||||.||.|.
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LQSRDPDSGETYIAKEFK
|.....|.|||....||.
laekvadtgetglerefq
subfamily_PTPRD_pd Subfamily PTPRD 1-320 1.4e-150 497.6 In-house 4-321 (564) alignment 
Range on Protein: 1-320
Range on HMM: 4-321/564.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
||||..|.|...  ..... .|.||. .|... .|.|... |..||.||||.|||| ||.|| .|...| .|||||||.|||||..|...||||||...|
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaet

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIeIANSDVESpaREIVQYHYTAWPDHGVPTHATSLL
..||||||||. .|.|||.|...|.|| ||.||||. ..|.||.|.||. |||||..|.||.| .   ... ||  ||. |.|.|.|||||||..|||||
iedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkksses..reVrqFhFtsWPdhgvpesatslL

AFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKAL
..||..|.. ..||||||||||||||||||.||.||||... .|. |||...|.. | |||.||||| ||||||.|..|| .||||| ....|..... |
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

QSRDPDSGETYIAKEFKNLDI
.. ..|.. |....||..|  
aeveedtemtgleleFqrLat
subfamily_PTPRA_pd Subfamily PTPRA 1-314 9.1e-104 341.9 In-house 13-329 (330) alignment 
Range on Protein: 1-314
Range on HMM: 13-329/330.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRT-PGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSN
|.||.|| |  .|. .  || |.||| .. . | . . . . ||||| |||. ||.  |..|| .|...|.. |||||| |||||....||||.||| ..
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee

TFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIE-IANSDVESPAREIVQYHYTAWPDHGVPTHATS
| .|||||.||.  . |||.|.. || . ||..|||.     || . |.  .|..| .| .|||... ....  | ..| . |.|.|.||| |||...  
tvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIK
.| .......   . |||||||||||||||||.|||||.|...  |. ||.|.||.. ||||  ||||. || ||. .|.|    |.||..|  |  ...
mlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlq

ALQSRDPDSGETYIAKE
 |... ..  .. . .|
klynkitgtdkigleee
subfamily_PTPRB_pd Subfamily PTPRB 1-282 1.4e-103 341.0 In-house 6-287 (293) alignment 
Range on Protein: 1-282
Range on HMM: 6-287/293.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPG-NFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSN
|| ..|..|. .  ..  .  |.||.  ... | . . . . ...|. ||||.||.. ||.|| ...|.. .||||||||.|.||| ...|||||||. .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA-NPEEYGRLVVTPLEEEELSHYVIRKFCIEIansdvESPAREIVQYHYTAWPDHGVPTHATS
|.|||||||||. .| |||.|..||.|| ||..|||.  .|  || . || ..||||...|||.. ||      |.  |.. |||.|.||||||| ....
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvPektkt

LLAFIRRIRNSV--SRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKC
||.|.|..|...  . ...|||||||||||||||.| || .|.....|  |||||.|.. | .||..||||.||||||.....  . 
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0051299 (Phosphotyrosine protein) phosphatases II 1-280 5.1e-102 336.4 In-house 4-286 (288) alignment 
Range on Protein: 1-280
Range on HMM: 4-286/288.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPG-NFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSN
.|.|..|..... .. .|.. ..|||  ..    .... ..|..||..||||..|.. ||.|| .| |||..|||||||..|||||. .|||||||| .|
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIAN-SDVESPAREIVQYHYTAWPDHGVPTHATS
|..||||||||.....|||.|..||.|. || .|||. ....||...|| |.||.|..|..|.....  .  | ..  |.. ..|||.|||||||.....
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
||.|.|..|.. . . ||.|||||||||||||.|.|| .|.|. ||| ||....| . | ||..||||. ||.|...||.|..
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 1-278 2.2e-95 314.6 In-house 1-275 (278) alignment 
Range on Protein: 1-278
Range on HMM: 1-275/278.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
||.|..|.....  . .... ...||  ...   ......|..|||.|||| .|.  ||.|| .| |.| ..||||||...||||. .|||||||| ..|
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPsANPEEYGRLVVTPLEEEELSHYVIRKFCIEIansDVESPAREIVQYHYTAWPDHGVPTHATSLL
..||||||||.|...|||.|. ||.|. ||..|||  ....||...|| |.||.|..|..|.....      ... |....|||..|||||||.. ..||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn...lgdgesrtvthyhylgwpdhgvpeslslll

AFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
 |....|. .. . ||..||||||||||||.|.|. .|.|. ||| ||..  |.. | || ..|||. ||.|...||.|
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-315 1.5e-94 311.5 In-house 5-314 (315) alignment 
Range on Protein: 1-315
Range on HMM: 5-314/315.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
|||...|  |   .... .. ||...  |     .  | . | ||| |||| ||.| |..|| .  |.  |.|||.|||||||||.....||.|||  ..
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvas

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAnPEEYGRLVVTPLEEEELSHYVIRKFcieiaNSDVESPAREIVQYHYTAWPDHGVPTHATSLL
 .||||.|.|. .. |||.||.||. | |..||||      ||.. ||  .||  ..| .| .        ...  ||.||.|||.||| ||| ....|.
vkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl.....svvfgdnirevvqlhytswpdmgvpkytiplm

AFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKAL
 .||...     ..|.||||||||||||||.| |||.|||.  | |.|.. |.   | .|  |||. .|| ||.|||.|.  ||.|    .   .| ..|
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl

QSRDPDSGETYIAKEF
 .  ||.| | . ..|
lapspdtgstllqeqf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-317 1.1e-77 256.0 In-house 2-314 (315) alignment 
Range on Protein: 1-317
Range on HMM: 2-314/315.0
PIPVNKLAEYCQIHHSTgnKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
|||| ..  . .  . |    | |||  .  |  .    . ...| .||||.||.  |..|| .  .| .| |||||| .| .... . .||.|||   .
pipvaqfpafvnknrht..alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPS--ANPEEYGRLVVTPLEEEELSHYVIRKFciEIANSDVespAREIVQYHYTAWPDHGVPTHATS
 |||||||...  . |||||.  |  |.||..|||   |.  |.| . |. |. |  .  |.||.   . .|.     | . |...| |||.||. ...|
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrksee...srtvtqfqftewPdkGvdkqtss

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIK
|| .|. .. .  ..  ...|||||||||||  | .| ...|. .. .||.| ||   | .|  .|||| .| ||.||..|  .  ||  .|  . |...
llklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlq

ALQSRDPDSGETYIAKEFKN
 |..    || . ..|||..
dlhtsvdgsgrskmtkefet
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-290 1.4e-69 229.5 In-house 9-294 (297) alignment 
Range on Protein: 1-290
Range on HMM: 9-294/297.0
PIPVNKLAEYCQIHHSTgnKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHrnKFIATQGPVSNT
|||. ..| . |  ..|  . |.||| |. .   ..   . |  | .|.||.||.  |  || .  ..  | |||.|| |. |..|  ..|.|| |  .|
piplsdfatlvqknrht..dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkat

FDDFWRMVWEHGCSCIVMVTNIVERGKlKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVespAREIVQYHYTAWPDHGVPT--HATS
 .|||.||...  | |||...  || | ||..||.     ..| ..|. |  .| . .. |.. ..  .. .    | . ||... |||. |.   .|.|
vadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkaka...rrvvkqyqfveWPdkaverkdsass

LLAFIRRIRNSVSRDAG-PIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQ
|| .|  .|.. |  |  |..|||.||||||| .. .| .. .. .| .|||||.|.. | .|  .|||. || |.. |..||  . .|. ...
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-319 3.1e-62 205.2 In-house 3-275 (392) alignment 
Range on Protein: 1-319
Range on HMM: 3-275/392.0
PIPVNKLAEYCQihHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
|||| ..  . .  .   .  | |||  .  |  .    . || |..||||.||.  | .|| .  .| || |||.|| .|....  . .||.||| . .
pipvaqfpafve..knrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

FDDFWRMVWEHGCSCIVMVTNIVERGklkcqkywpsanpeeygrlvvtpleeeelshyvirkfcieiansdVESPAREIVQYHYTAWPDHGVPTHATSLL
.|||||||...  . |.|||.. |                                                   || . |.|.| |||..|| |..|||
lddfwrmvfqenvttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssll

AFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKAL
 ||. ..    . . |...||||||||||  | .|... .  |   ||.| ||.  | .| .||||. || ||. |..|     ||   |  . |... |
kfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdl

QSRDPDSGETYIAKEFKNLD
..     . .   |||..| 
stssdGdvrskqlkefrslk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1-85 1.7e-10 34.8 In-house 5-88 (440) alignment 
Range on Protein: 1-85
Range on HMM: 5-88/440.0
PIPVNKLAEYCQIHHstGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNH
|| |  .|.| |  .    ..|..|.  . .      | .   .|| ||||.||.| ||.|| . |. |.| |||||| .|.| . 
piivadfadyvqnnr..rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-318 1.2e-122 403.9 In-house 2-318 (318) alignment 
Range on Protein: 2-318
Range on HMM: 2-318/318.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCI-RTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
|.|..|..  .  ...|.  ..||.  . |.. .... .||.. || ||||.||.| |||||....|.| .||||||||.||||......||.|.|...|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIanSDvESPAREIVQYHYTAWPDHGVPTHATSLL
..|||||||| ... |||.|...|||| |...|||| ....||.|||.  || |||.||.|.| ..   .. |.  |.. |||||.|||.|||....|||
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..te.eeesrqvrqyhytsWpdegvpesgasll

AFIRRIRNSV-SRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKA
...|....   . .||||||||||||||||..|..|..|... .|. ||.|..|.. | |||.||||| ||.||.|.|.|| ..|.|| . .||..||. 
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

LQSRDPDSGETYIAKEFKNL
|. .||.||.|..  ||..|
lreqdpesgttemdaefqrl
subfamily_PTPRG_pd Subfamily PTPRG 2-294 1e-109 362.3 In-house 1-301 (563) alignment 
Range on Protein: 2-294
Range on HMM: 1-301/563.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCI---RTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGS-DYINANFIDGYNHRNKFIATQGPV
.||...|..    |. |.. |.|||  .    .. ..  .|| |.||| |||| |||| |..|| .|.| |. .. ||||||.||||.. ..|||||||.
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

SNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEI---ANSDVESPAREIVQYHYTAWPDHGVPT
 .||||||||.||.  . |||.||.||||. ||. |||. ..|.|| | ||  ||| |. | .|.. |.     . .     ... ||||| |||||||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLH
|..  | |...   .  ..||||||||||||||||||||||..| |. .| ||..|||. | |.|||..|||| ||||.||||.|| . ..|| . ....
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

D
.
e
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-300 9.1e-98 322.1 In-house 4-303 (305) alignment 
Range on Protein: 2-300
Range on HMM: 4-303/305.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPgNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTF
| ...||.| . .... .|......  . .  . | |   ||.|| |||...|.  |. |. ..| .  . ||||||...|||....|.|..|||. || 
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

DDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE--EYGRLVVTPLEEEELSHYVIRKFCIEIANSDVESpaREIVQYHYTAWPDHGVPTHATSL
.||||...|   | |||.|..|| || ||..||| .  |  |.|...|.  .|.. | |..||..| |...| ||  | ..||. | |||||||. ||||
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkes..rtvlqyqltdWPdhGvpqfatsl

LAFIRRIRNSVSRDAG-PIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIK
| .|.|.... ..| | |..|||||||||||..|..| .|... ||. ||.|. . . | .|  |||| .|| |.|||| |  .||.|.  ...|. |..
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvn

ALQ
 |.
klk
0039614 (Phosphotyrosine protein) phosphatases II 2-284 9.4e-94 309.4 In-house 14-293 (297) alignment 
Range on Protein: 2-284
Range on HMM: 14-293/297.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNfSWDHSLKEENKPKNRYQN-IVADHTRVAISELDGI-PGSDYINANFIDGYNH-RNKFIATQGPVSN
||.. |. ...... ...  ...||. .      .. ..|..|||.||||.. .  ||.|| .. .||  ..||||||...|||..  .|||||||| ..
iplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe

TFDDFWRMVWEHGCSCIVMVTNIVERGKlKCQKYWPSANPeEYGRLVVTPLEEEELSHYVIRKFCIEIansdvESPAREIVQYHYTAWPDHGVPTHATSL
|..||||||||.|...|||.|. ||.|. ||..|||.    .||...|| |..|.|..|..|.....      ... |.. ...|| ||||||| ....|
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.....ngesrtvthfqytgwpdhgvppslell

LAFIRRIRNSVSR--DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGN
| |.. .|. ...  . ||..||||||||||||.|... ||.|. ||| ||..  |.. | ||...|||. ||.|..|||.|  |...
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Ptp69D_pd Subfamily Ptp69D 2-299 4.3e-93 306.8 In-house 4-305 (307) alignment 
Range on Protein: 2-299
Range on HMM: 4-305/307.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCIR-TPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
|.. .|.|  . ..   .  ...|.  .  .  . |   | |.||. ||||..|.| |.||| .... |   ||||||.|| ||....|||| |.|| .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDV--ESPAREIVQYHYTAWPDHGVPTHATS
 .|||||..|     |||..|. |  . ||.||||  .  .|| ..|.. .||. |.|.||.. .   . ..  .   |..||||||.|.|  || .|..
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIK
|| .|...|.  . . .||||||||||||.|... || .|.|. .|  |||| .| . | |||..||  .||.|.. ||..  . |.|. .|.||.|.|.
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie

AL
 |
rl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-282 1.9e-81 268.1 In-house 2-285 (290) alignment 
Range on Protein: 2-282
Range on HMM: 2-285/290.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCIRT-PGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPG--SDYINANFIDGYNHRNKFIATQGPVS
|||.|..|. . .|..||..|...|. . .   ...  . | ..||..||..|||  |  |. . .. | .    .|||| .|.||......||||||||
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

NTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDveSPAREIVQYHYTAWPDHG-VPTHAT
||  |||...|.. ...|||.|||.| || |||.|||... ..||   .. |.||.|..|..||. ..  ||.   ......||. |.|...| |. ..|
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqt

SLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKC
.||.. .....   |  ..||||||..|||........  .... .|| .|.|  . . | |.  .|||. || .|.. .... ..
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-286 1.7e-79 261.8 In-house 2-284 (287) alignment 
Range on Protein: 2-286
Range on HMM: 2-284/287.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCIRT--PGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISeldgIPGSDYINANFIDGYNHRNKFIATQGPVSN
|||.|..|. .  | .||. ||. |. .      . .  |.. ..||.|||...|.  |  || .         ||||| |||||.....||....|..|
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKfcIEIANSDVESPAREIVQYHYTAWPDHG-VPTHATS
|  .||......  . |||...  |  . .| .|||. .   .|   .. |.||  ..|..||  .|. |.. ... ....||..|.|...| |....|.
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierk..levknknkagdkqqvkqyqitnWdstgkvtepqti

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTE
|| . .....   |  ..||||||..|||.....  .  ...  .||..|.|  . . | |.  .||| .||.|| |...|  ....| 
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
0045450 (Phosphotyrosine protein) phosphatases II 3-279 5.9e-92 303.9 In-house 10-303 (307) alignment 
Range on Protein: 3-279
Range on HMM: 10-303/307.0
PVNKLAEYCQIHHSTGNKSFKEEFMCIRTPG---NFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGI-PGSDYINANFI--------DGYNHRNKF
.. ||  .... . ...  ...||  ..      .......|..|||.||||..|.  ||||| .| |||  ..||||||...        |||.. .||
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf

IATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE-EYGRLVVTPLEEEELSHYVIRKFCIEIAnsDVESPAREIVQYHYTAWPD
|||||| ..|..|||||.||.|...|||.|. ||.|. || .|||. . | .||...|| |.||.|..|..|.....    | ... |.. ..|||.|||
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl..dgtgesrtvthfhytgwpd

HGVPTHATSLLAFIRRIRNSVSR--DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGA---VDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
||||..  .||.||...|. ...  . ||..||||||||||||.|... ||.|. |||    ||..  |.. | ||  .||.. ||.|...||.| 
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-316 7.5e-76 250.3 In-house 6-324 (325) alignment 
Range on Protein: 3-316
Range on HMM: 6-324/325.0
PVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFD
 | .| |. . ...  . .|  ||  . . .  .   . | ||| |||..|.|| |..|| .  ..  | ||||||...  .  .. |.|.| | ..| .
avvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

DFWRMV--WEhgcSCIVMVTNIVERGKLKCQKYWPSA--NPEEYGRLVVTPLEEEELSHYVIRKFCIEIANsdvESPAREIVQYHYTAWPDHGVPTHATS
|.||.|  |.   . .|.|.|... || .| .|||    .  ..| | |     ||.| || |.. .  ..   .  .| . |... .|.| ||. . ..
dlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk...kGetrsvkqfqlqswddmGvqkrpat

LLAFIRRIR---NSV---SRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQD
|..... .    . |   .. ..||.|||||||||||..| | ..|... .|  ||||||| . | .|  ||.|  |||.|..||.||  .|||.  |  
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvss

LHDRIKALQSRDPDSGETYIAKEFK
.. .. .|| |.| . .  | |||.
feaklsslqernpltqklniekefe
0040438 (Phosphotyrosine protein) phosphatases II 4-316 9e-102 335.8 In-house 2-312 (317) alignment 
Range on Protein: 4-316
Range on HMM: 2-312/317.0
VNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDD
|..| ....  .  ... ..|||. ...    ........|||.|||| .|.  ||.|| .| |.|...||||||...||.|...|||||||| .||..|
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIAnsdVESPAREIVQYHYTAWPDHGVPTHATSLLAFI
|||||||.|...|||.|. .|.|. ||..|||. .. .||...|| |.||||.....|....|      .|. |.. ..|||.||||||| . ..||.|.
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl...gdsesrtvthfhytgWpdhgvppspdllldfl

RRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKALQSR
...|.. ... ||..||||||||||||.|... ||.|. ||| ||..  | . | ||...|||..||.|..|||.|  |...|   ...|. ... |.  
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllip

DPDSGETYIAKEFK
.. .. ... ||.|
lalddvklkekelk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 6-94 1.9e-13 44.4 In-house 9-95 (95) alignment 
Range on Protein: 6-94
Range on HMM: 9-95/95.0
KLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISEldgIPGSDYINANFIDGYNHRNKFIATQG
 .  .    ||  .. | .||  |      ..     | | ||||. ||.  | |||...       |||||| |.|||  .| .||.||
vfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 7-286 6.6e-94 309.5 In-house 14-296 (298) alignment 
Range on Protein: 7-286
Range on HMM: 14-296/298.0
LAEYCQIHHSTGNKSFKEEFMCIRTPGN----FSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFD
| .. .......   ...||  ...  .    .... . |.||| ||||..|.| |..|| ... |.   |||||| |...|..|| |||||.|. .|. 
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetve

DFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDvesPAREIVQYHYTAWPDHGVPTHATSLLAF
||||||.|.  ..|||.||..| .|.|..||||. . |.||.. |. |..|| . ...||. .. ....     ||..| |.| |||.|||..|||.|..
dFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee...kerevrqlhftsWpdkgvpenatsvldl

IRRIRNsVSRDAG--PIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTE
.|..|    ..||  |..|.|||||||.||.|..|..|... ||  ||.|  |   | .|  .||||.||.||..| .|| ...|.|
lrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 7-279 3.8e-87 287.0 In-house 2-275 (281) alignment 
Range on Protein: 7-279
Range on HMM: 2-275/281.0
LAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDH-SLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFW
| . .. ...  |. |.||.  ..  |. .  . | ..||. ||||.|||| |.||| ... .    .|||||||..||.  ...||||||| .....||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN-PEEYGRLVVTPLEEEELSHYVIRKFCIEIANsdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIR
.||||.  | |||||. .| ||||| .|||  |   .|| ..|. ..||| ..|. ||| .|  .    ...||..| .||||||||||. .. || | .
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleres....getreveqlaytaWPdhGvPattkellefrk

RIRNSVSRDA-GPIVVHCSAGVGRTGTYIVLDAMLDQMSK-EGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
 ...  ...   |.|.||||||||||||| || ....... .  .|.   | . | .||.|||| .|| |.. |...|
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 7-342 8.6e-77 253.4 In-house 4-340 (515) alignment 
Range on Protein: 7-342
Range on HMM: 4-340/515.0
LAEYCQIHHSTGNK-SFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFW
||..   .   ..   | |||  .  |  .    . .| | .||||.||.  | .|| .  ..  | |||.|| .| ...  . .||.|||   . ||||
laqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfW

RMVWEHGCSCIVMVTNIVERGKLKCQKYWPS--ANPEEYGRLVVTPLEEEELSHYVIRKFCIeIANSDvespAREIVQYHYTAWPDHGVPTHATSLLAFI
|.|...  . |.|||.  |  | || ||||   ..  ..| . |  .  |  .  ..||. . . ..|    .| . |.|.| |||.||| |..||| .|
rlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv.lkgdd....srtvtqfhfteWPdkGvpkhtssllkli

RRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKALQSR
. .. . .. . |...|||||||||| .| .| .. .. .  .||.| ||   | .|  .|||. || ||..|..|  .  ||   |  . | .. |.| 
kevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhss

DPDSGETYIAKEFKNL--DIGDSDVETFDSASMPENKSKNRF
    | . ..|||. |   . |  .    |.   .|. |||.
gdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknry
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 10-280 2.6e-92 304.0 In-house 11-279 (288) alignment 
Range on Protein: 10-280
Range on HMM: 11-279/288.0
YCQIHHSTGNKSFKEEFMCI-RTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMV
. .. . .... |.||.  .     . | . . . .|..||||.||.. |..|| . .|.  .|.|||||..|||.....|.||||||. .| .|||..|
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WEHGCSCIVMVTNIVERGKLKCQKYWPSAN-PEEYGRLVVTPLEEEELSHYVIRKFCIEiansdVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIR
.|.  | |||.|..||.|| ||..|||.|. |..|| . || .|..|| ..| ||. .|      .   .|| ||.|.||||||||  .. ||...| . 
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.....kkkteleitqyqylaWpdhgvPeskapllellrqvk

NSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
.. . |.|||.||||||||||||.|.|||..|.. .|  .|..|.|.. | ||...|||. ||.||...|.. .
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN6_pd Subfamily PTPN6 11-278 4.8e-86 283.5 In-house 17-295 (306) alignment 
Range on Protein: 11-278
Range on HMM: 17-295/306.0
CQIHHSTGNKSFKEEFMCI---RTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISeLDGIPGSDYINANFIDG--YNHRNKFIATQGPVSNTFDDFW
 . ..|.... |.|||  .    .   .| ... | ||| ||||.||.  ||||| ..  ...|||||||||.|..   ......||||| ...|  |||
ekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

RMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN-PEEYGRLVVTPLEEEELSHYVIRKFCIEIAnsDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIR
||||.  .  |||.|. ||||| || .|||...  ||||.. || ..|..|..|..|.. ..    . .. .||..|||...|||||||..   .|.|..
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk..kkkkeerevfqyhfksWPdhgvpkdpgavLdfle

RIRNSVSR----DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEG---AVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
 ...  ..    .|||||||||||.|||||.||.|..|....|.|    .||  .|  .| ||. .||||.|| |.. |. .
dvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_PTPN9_pd Subfamily PTPN9 12-281 2.3e-80 264.8 In-house 8-291 (297) alignment 
Range on Protein: 12-281
Range on HMM: 8-291/297.0
QIHHSTGNKSFKEEFMCIRT-PGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWE
.  ...|..  ..|.. ||  | .   ..| .  |  ||||....  |.||| ....|. . ||||||||.|||.... |||||||. .|..||||||||
ayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWe

HGCSCIVMVTNIVERGKLKCQKYWP--SANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANsdvESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRN
. .  |||.| .||||.|||..|||  . . .|.| | |. .| || ..|..|.. |. ..   ..  |... . ...|||.|||  |.||| ... .|.
qevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk...teesrkvthfqflsWPdyGvPssaaslldvlekvre

SVSR-------------DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAK
  .              .  |||||||||.|||||.| ||  |... ..| ||..  |.. | ||  ..||. || | . |..| |.
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
0049772 (Phosphotyrosine protein) phosphatases II 13-284 3.5e-49 163.6 In-house 14-284 (314) alignment 
Range on Protein: 13-284
Range on HMM: 14-284/314.0
IHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVADHTRVAISELDgIPGSDYINANFIDGYnhrNKFIATQGPVSNTFDDF---------
|| .  .  ..  .  .........  . ...|. ||||..|.   .|| .. |. . |||||||...||.   .|||||||| ..|..||         
ihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpadnrvilpglp.vsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyn

-WRMV--WEHGCSCIVM---------------------VTNIVERGklkcqKYWPSANPEEYGrlvvtpleeeelshyvirkfcieianS----DvESPA
 ||||  ... .  |||                      ... ..|      ... |..|..                           .    . | . 
gwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk..........................eelydp.elfe

REIVQYHYTAWPDHGVPtHATSLLAFIRRIRNSvsRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKeGAVDIFGFVSHTRLqRN---MMVQTEAQYIFI
|....|... .||...|     ...|.. |..   .. ||..|||.||.|||||..|.. .. ..    . ... .|  .|   |    ....  ||.||
rlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefi

HDALMEAAKCGN
..||.|. |   
lealleylkflk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 13-280 6e-45 148.3 In-house 15-287 (305) alignment 
Range on Protein: 13-280
Range on HMM: 15-287/305.0
IHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEE-NKPKNRYQNIV-ADHTRVAIselDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEH
     | . ...||....   .|   ...||  .. ||||...   |. || .   .|    .|| ||..      ..|| || |. .|  ||| | ...
rtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqd

GCSCIVMVTNIVERGKLKCQKYWPSANP-----EEYGRLVVTPLEEEELSHYV-IRKFCIEIANSDVESP---AREIVQYHYTAWPDHGVPTHATSLLAF
    | |. |..|.|  ||..|..| .      || |. ..  .|  .  ...   |  .. .   .| |   || . .||.  ||| |||.  ...| .
kveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel

IRRIRNSvsrdAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDI-FGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
. . | |     ||||||||||.||||. ..|. .|||.     ..     . . | |||  .||.|||.|.|. ...  
lekarps....kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
0047943 (Phosphotyrosine protein) phosphatases II 15-279 5.6e-92 303.3 In-house 7-271 (273) alignment 
Range on Protein: 15-279
Range on HMM: 7-271/273.0
HSTGNKSFKEEFMCIRTPG-NFSWDHSLKEENKPKNRYQNIV-ADHTRVAIseldGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGC
...|.. ..|||  ..    .... ..|..||| ||||..|.  ||.|| .    | .|||||||...||||. .|||||||| .||..||||||||...
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

SCIVMVTNIVERGKLKCQKYWPSAN---PEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVespAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSV
..|||.|..||.|. || .|||. .   ...||.. || |.||. ..|..|.....  ...     |.. ..||| |||||||.. .||| ||. .|.  
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge...srtvthfhytgwpdhgvppslesllefielvrkal

SR--DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
.   . ||.|||||||||||||.|.|| .|||. ||| ||..  | . | || .||||. ||.|...||.| 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0050432 (Phosphotyrosine protein) phosphatases II 16-285 6.7e-99 326.4 In-house 38-304 (308) alignment 
Range on Protein: 16-285
Range on HMM: 38-304/308.0
STGNKSFKEEFMCIRTPG-NFSWDHSLKEENKPKNRYQNIVA-DHTRVAIseldGiPGSDYINANFIDGY--NHRNKFIATQGPVSNTFDDFWRMVWEHG
 .... ..|||. ..    .......|..|||.|||| .|.. ||.|| .    . .|||||||...|||  ....|||||||| .||..||||||||..
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

CSCIVMVTNIVERGKLKCQKYWPSA---NPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDvesPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNS
...|||.|..||.|. || .|||.    ...|||...|| |.||.|..|..|.....  ...   . |.. ..|||.|||||||.....||.|....|.|
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg...esrtvthfhytnWpdhgvPpspeilldflelvrks

VsrDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNT
   . ||||||||||||||||.|.|| .|.|. ||| ||.|. | . | ||..||||. ||.|...||.| .|.  |
l..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 16-294 5.6e-63 207.5 In-house 5-280 (283) alignment 
Range on Protein: 16-294
Range on HMM: 5-280/283.0
STGNKSFKEEFMCIRTPGNfSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGipgsDYINANFID---GYNHRNKFIATQGPVSNTFDDFWRMVWEHG
...|| |.| .  .  |   . | .  .|||.|||.|.|| ||  || .  .      ||||| ||     |.. .|.|..|.|. .|  |||.||... 
vnnnklfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

CSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIAnSDVESPAReIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSR
 ..|||.|.. |  . || .|||.   |.|| . ||  .|     ..|... .    |  .|    .  | .  | . |  .   ||. | . | .    
itaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn.ssakstll.lahyqvidWleygeqaiinslvkfnkvislqtes

DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHD
  ||||||||.|.|||...| . | ....  |  ||.|  |   | || |.|||  || ..|.. .| | ||.|.    ||..
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 16-285 3.3e-61 201.6 In-house 11-298 (301) alignment 
Range on Protein: 16-285
Range on HMM: 11-298/301.0
STGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDG--IPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGC
.. ...|.|..  ...  . | . .|.||||. ||..||.  |. |. ...     .   .||||..||||....||||.|||. .|  ||||..|..  
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

SCIVMVTNIVERGKLKCQKYWPS--ANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDV------------ESPAREIVQYHYTAWPDHGV-PTHATS
. ||||||  |. | ||..|||.  |. ||.| . ||  .|  .  .|||.... | ..              .  .....|.. | ||..|| . ..| 
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNT
| .    |    . . ||.|||||..|.|.|.|. ..  |.|   || ||.|. .   | ..  .|.|  ||..|.|.. .  .. .|
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_PTPRK_pd Subfamily PTPRK 18-316 4.3e-98 323.0 In-house 20-313 (314) alignment 
Range on Protein: 18-316
Range on HMM: 20-313/314.0
GNKSFKEEFMCIRTPgnfsWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIV
 .  ||||. ..       || . |.||. |||...|.| |..|| .  .|| | ||||||..||.|.. ..||.||||. .|  ||||.|....|..||
egygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv

MVTNIVERGKLKCQKYWPSANPEeYGRLVVTPLEEEELSHYVIRKFCIEIANSDVeSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPI
|.|..|| |..|| ||||      || . |. .| | |. .|.| | .| ..  . .  ||. |.....||||.||..||.||...||. .|   .||.|
mltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargq.eeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGri

VVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKALQSRDPDSGETYIAKEFK
||||||| |||||.|..| .|| . .|| ||.|  |   | ..  ||.|| ||.||.|...||. ||.|   | ...   .  .  ||..  . . .||.
vvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefq
0036941 (Phosphotyrosine protein) phosphatases II 19-292 6.2e-95 313.2 In-house 12-289 (297) alignment 
Range on Protein: 19-292
Range on HMM: 12-289/297.0
NKSFKEEFMCI-RTPGNFSWDHSLKEENKPKNRYQNI-VADHTRVAIselDGiPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIV
.  ...||. . .   ..|....|..||..|||| .|   ||||| .   |. .|||||||...|||.. .|||||||| .||..||||||||.....||
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MVTNIVERGKLKCQKYWPSA--NPEEYGRLVVTPLEEEE--LSHYVIRKFCIEIANSDvesPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVS--
|.|. ||.|. ||..|||.   .. .||...|| |..|.  |..|..|.....  ...   . |.. ..||| |||||||....|||.||...|.  .  
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng...esrtvthfhytgwpdhgvpespaslldfielvrkvlkll

RDAGPIVVHCSAGVGRTGTYIVLDAMLDQMS---KEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDL
.. ||..|||||||||.||.|..| ||.|.    ||| |||. .| . | ||...|||. ||.|...||.|  |...| . ...|
psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 20-296 4.8e-77 254.3 In-house 20-295 (439) alignment 
Range on Protein: 20-296
Range on HMM: 20-295/439.0
KSFKEEFMCIR-TPGNFSWDHSL--KEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCI
. |||.|  |  |  ... . ||  .| ...||||....| |||||.. |. |.| | |||||.|.||   . .||||||  .| |||||.|.|. .. |
eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

VMVTNIVERGKlkcqkYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIeIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSV-SRDAG
||.||.||  |     |||| .   || ..|    . || .|||| | . . . |     | ..|.||.||||. ||..|. .| |.| |  .  ... |
vmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkv.fnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeyg

PIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRI
|.||||||||||||| | ||  |.|.  |  ||| | |.  | ||. |||. .||.||..|..|  . |..   ..... ..
pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkef
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 20-282 6.9e-72 236.8 In-house 5-270 (274) alignment 
Range on Protein: 20-282
Range on HMM: 5-270/274.0
KSFKEEFMCIrtPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDG-IPGSDYINANFIDGYNHRNK-FIATQGPVSNTFDDFWRMVWEHGCSCIV
|....||. .  | ||. ..     .. ||||..|.  ...|| ... ..  . |.|||||.| ||....| ..|||||..|| .|||||.... .. ||
kdlekeflel..PlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MVTNIVERGKLKCQKYWPSANP----EEYGRLVVTPLEEEELSHYVIRKFCIEIANSdvespAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRD
|.|.. |. . ||..|.| |.     |.|| . ..  .  |  .| .||. .. ...      |... | ||.|||| .| .|..|| ... ...| ...
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.....ersvkhywytdWPdhksPddantlldlvleveesreee

---AGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKC
   ..|.|||||||.|||| .|  .  . |. .|. ||... |.. ||.|  ||||. || .|| ||.. .|.
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 20-278 1.4e-48 160.5 In-house 16-275 (307) alignment 
Range on Protein: 20-278
Range on HMM: 16-275/307.0
KSFKEEFMCI--RTPGNFSWDhsLKEENKPKNRYQNIVA-DHTRVaISELDGIpGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIV
.....||  .  .||   . .    . |  |||||.. . |..|. . ..||.  |||| ||..    . .|||..|||  ||  .|| |. ..   ...
qalvdefrvlakktpegvtve..afsantdknryqdvkcqdkgri.vvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvi

MVTNIVERGKLKCQKYWPSANPEE--YGRLVVT-PLEEEELSHYVIRKFCIEIANSDVE--SPAREIVQYHYTAWPDHGVPTHATSLLAFIrrirNSVSR
|. ...| .|.||..|||  . ..  .|    |  ...    .    . .|.... .|.  . .| | .. .. |||.|||    . . ..    ..|  
mlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll....eavry

DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSK-EGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|  |.||||||||||.|| . .  . |.| . .   |.  .|   | ||.  .||||||...|  |.|
dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_ptpA1_pd Subfamily ptpA1 20-239 2e-44 147.0 In-house 21-255 (418) alignment 
Range on Protein: 20-239
Range on HMM: 21-255/418.0
KSFKEEFMCIRT-PGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYnHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVM
.  ||||  .    |        |. |  |||| ||.  .|||| . ...   ||||||||.|||  . ..||.||||. ||  ||||||||  |  |||
hkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivm

VTNIVERGKLKCQKYWPSANPEE----YG--RLVVTP--LEEEELSHYVIRKFCIEIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNS-
..   |  ..||..|||     |    ||    |.    .|  |. .   |.         .|  .|.| ||.|  |||| .| |.  .  ... | |  
lsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

--V---SRDAGPIVVHCSAGVGRTGTYIVLDAMLDQ
  .   |    ||.||||||||||||.     |. .
nqiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_PTPN1_pd Subfamily PTPN1 21-295 9.7e-65 213.1 In-house 7-286 (290) alignment 
Range on Protein: 21-295
Range on HMM: 7-286/290.0
SFKEEFMCIRTP-GNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGipgsDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMV
..|| .. ||    .|.  .. ..||...|||...   ||.|. . . |     |||||....  . . ..| ||||..|| | ||.||||. . ..||.
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml

TNIVERGKLKCQKYWPSANPE-----EYGRLVVTPLEEEELSHYVIRKFCIEIANSdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNS--VSR
 ..||....||..|||. . |     |  .| |. ..||. |.|..|.. .|  ..     .|||...|||.||| |||   ...| |. ..|.|  .|.
nkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlkt...qetreilhfhyttwpdfgvpespaaflkflfkvresGslss

DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGA---VDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDR
| || |.|||||.||.||....|..| .. |..    |||   . . | .|  ..||  |  | . |..| ||. ...  ||. . .
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqkrwke
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 21-281 1.1e-48 160.5 In-house 7-260 (267) alignment 
Range on Protein: 21-281
Range on HMM: 7-260/267.0
SFKEEFMCIRTPGNFSWD--HSLKEENKPKNRYQNI-VADHTRVAISELDgipgSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVM
....||  |.   . |     |. |.|. .||...    |.||| ... .     .|||| ...||. .|.||.||.|..||  ||. .. ..... ||.
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

VTNIVErGKLkcQKYWPSA--NPEEYGRLVVTPLEEEELSHYVIRKFCIEIANsdvESpAREIVQYHYTAWPDHgvpTHATSLLA--FIRRIRNSVSRDA
.|.. . ...  ...||    . ..|  |.|    |.|   | |  . ... |   || |.... |.|  |      |     |   |    .| .    
ltkvft.dni..rlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn...es.ahnvtlyyykkwnin...tnnkpylkplfgilaknqlengn

GPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAK
 |.||.||.||||.||..|.|..|... .|| .||| |. . | ||  .|.|  .||.||. | | |.
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
0045098 (Phosphotyrosine protein) phosphatases II 22-284 1.5e-86 285.5 In-house 10-276 (278) alignment 
Range on Protein: 22-284
Range on HMM: 10-276/278.0
FKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNI-VADHTRVAiseldgipgsDYINANFIDGYnhRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTN
. | .  .... . .. ..|...|..|||| .|   ||.||           |||||..||||  ..||||||||  .|..|||||.||.|...|||.|.
llefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

IVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSD-VESPAREIVQYHYTAWPDHGVPTHA--TSLLAFIRRIRNSVSR------
 ||.|. || .|||. ....||...|| |.||.|..|..|.. ..  ..   . . |.. ..||. |||||||..   .|.| ....||. ...      
lvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------DAGPIVVHCSAGVGRTGTYIVLDAMLDQMskEGAVDIFGFVSHTRLQRNM-MVQTEAQYIFIHDALMEAAKCGN
       . ||..||||||||||||..... ||...  || ||..  |.. | ||.. .||.. ||.|....|.|  ..|.
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_CG7180_pd Subfamily CG7180 22-284 5.6e-66 217.2 In-house 19-294 (296) alignment 
Range on Protein: 22-284
Range on HMM: 19-294/296.0
FKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTN
.| |.  . .  .    . |..||. |||. ..|  |..|| ...|||   |||||| ..|.. . ...| |..|. .| |.|||.|.....|..|..|.
yklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk

IVERGKlKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIA-------NSDVESPAREIVQYHYTAWPD-HGVPTHATSLLAFIRRIRNSVSRD
  .  | ....|||    |.|| ..|  .||..... .||.| .          . .|. . | . ....| |.  . ||  ...|. ..||.|  . . 
tfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv

-----AGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGN
      ||.||..| |..|.| |. .|| |....||. ||.|..|   | .|. .|..  .| .| | | ||  |. 
dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
0046845 (Phosphotyrosine protein) phosphatases II 23-287 9.9e-96 315.7 In-house 3-281 (284) alignment 
Range on Protein: 23-287
Range on HMM: 3-281/284.0
KEEFMCIRTPGN---FSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDG-IPGSDYINANFIDGY-----NHRNKFIATQGPVSNTFDDFWRMVWEHGC
.|||. ..       .|....|..||. ||||..|.  ||.|| .. ||| ...||||||...|||     ....||||||||..||..||||||||...
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

SCIVMVTNIVERGKLKCQKYWPSAN-PEEYGRLVVTPLEEEELSHYVIRKFCIEIAnsDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVS-
..|||.|..||.|. || .|||. . . .||.. || |.||. ..|..|.....    ..... |.. ..|||.|||||||.....||.|.| .|.. . 
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-RDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEG---AVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEF
  . ||||||||||||||||.|.|| .|.|. |||    ||... |.. | ||..||||..||.|...||.|..|...| .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 25-117 6.2e-09 29.8 In-house 19-115 (347) alignment 
Range on Protein: 25-117
Range on HMM: 19-115/347.0
EFMCIRTPGNFSWDHSLKeeNKPKNRYQNI-VADHTRVAISELDG-----IPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVM
| ..  .| .|.     |  .  ||| ..  . | ||| .|  .       .   ||||  |   | ....| || |. .|  |||.||     . .| 
enlanyspskftsvewek..slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 25-124 5e-06 19.5 In-house 10-80 (169) alignment 
Range on Protein: 25-124
Range on HMM: 10-80/169.0
EFMCIRTPGNFSWDHSLkeeNKPKNRYQ-NIVADHTRVAISELDGIPGSDYINAnfidgynhrnkfiatqgpvsntfddfwRMVWEHGCSCIVMVTNIVE
||| .    ||  . .    |. |||    .   |||| .  .    |||||||                           ||.||   | ||.. .  .
efmktieynnfmaeltc...netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtdd

R
.
k
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 25-124 6.8e-06 19.0 In-house 9-79 (169) alignment 
Range on Protein: 25-124
Range on HMM: 9-79/169.0
EFMCIRTPGNFSWDHSLkeeNKPKNRYQ-NIVADHTRVAISELDGIPGSDYINAnfidgynhrnkfiatqgpvsntfddfwRMVWEHGCSCIVMVTNIVE
||| .    ||  . .    |. |||    .   |||| .  .    |||||||                           ||.||   | ||.. .  .
efmktieynnfmaeltc...netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtdd

R
.
k
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 26-201 4e-34 112.8 In-house 16-189 (297) alignment 
Range on Protein: 26-201
Range on HMM: 16-189/297.0
FMCIRTPGNFSwdHSLKEENKPKNRYQNIVA-DHTRVAIseLDGIPGSDYINANFIDGY--NHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIV
..  . ...||   . ..    ||||..|.| | ||| .  | .|...|||||...     ..  |.| .|||.|.| ||||..|.|..   ||||... 
lldeargesfs..sakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklq

ERGKLKCQKYWPSANPEE--YGRLVVTPLEEEELShYViRKFCIEIANSDVeSPAREIVQYHYTAWPDHGVPTHATSLLAF
| |. ||  ||||.. |    | .||  | .     .  | .  |.      |  | .    . .|||||||.    |  |
edGrdkcapywpsvvqerlkagdvvveflsstsde.fd.rviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_PTPN12_pd Subfamily PTPN12 27-279 1.6e-79 261.8 In-house 22-276 (290) alignment 
Range on Protein: 27-279
Range on HMM: 22-276/290.0
MCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERG
   ..   .| ... ||||. ||||..|.  |..|| .|. .. .|||||||||| | . . ..||.|||...| ||||||.||.  . .||. ..|| |
ekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelg

KLKCQKYWPSA--NPEEYGRLVVTPLEEEELS-HYVIRKFCIEIAnsdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSA
| ||..|||.   .. |.| . ||  ||. ..  ..|| . .|       .  |.. |.|||||||||||. |.|||..|. .|.  .... |.||||||
kkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsa

GVGRTGTYIVLDAMLDQMSKEGA---VDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
||||||| |..| . ... .|     .|.|  | . | ||. .|||. || ... |..| 
GvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
DSPc_SM00195 28-280 6e-90 296.5 In-house 8-262 (263) alignment 
Range on Protein: 28-280
Range on HMM: 8-262/263.0
CIRTPG-NFSWDHSLKEENKPKNRYQNI-VADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERG
 ...   . . ... |..|| ||||.|| . ||||| ... .. .||||||||.|.|.|...|.|||||| ..|..||||||||.....|||.|. .|.|
kleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng

KLKCQKYWPSA--NPEEYGRLVVTPLEEEELS-HYVIRKFCIEIANSdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSA
| ||..|||.   ..|..|.. |.  |.|. . ....|.. ..  .    . .|.. ||.|..||||||| ...|.|...| ...| |.  |||||||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
|||||||....| .|.....|  ||||  |.. | || .||||..||.||..|..|..
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 28-280 6e-90 296.5 In-house 8-262 (263) alignment 
Range on Protein: 28-280
Range on HMM: 8-262/263.0
CIRTPG-NFSWDHSLKEENKPKNRYQNI-VADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERG
 ...   . . ... |..|| ||||.|| . ||||| ... .. .||||||||.|.|.|...|.|||||| ..|..||||||||.....|||.|. .|.|
kleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng

KLKCQKYWPSA--NPEEYGRLVVTPLEEEELS-HYVIRKFCIEIANSdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSA
| ||..|||.   ..|..|.. |.  |.|. . ....|.. ..  .    . .|.. ||.|..||||||| ...|.|...| ...| |.  |||||||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
|||||||....| .|.....|  ||||  |.. | || .||||..||.||..|..|..
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 28-297 4.9e-86 283.9 In-house 44-308 (319) alignment 
Range on Protein: 28-297
Range on HMM: 44-308/319.0
CIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTnivergK
| ...     ...  ..|| |||. ||.| |...| .  |.|. .|||||| |..|| ...|.||.|||  || .|||||.||. || ||..|      |
cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......k

LKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFciEIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRD--AGPIVVHCSAGV
 || .|||    ....|  |     || . ||.|..  |...   |   |.| |.|.  |||.||| ... |. .....|   |.     .|||||||||
dkcsqywplkivikeerfkvkvdsveetaeyvvrdi..elsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGv

GRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIK
||||.|||||..||.| .|  ||.. ||   | ||| .||  .|| ||. ||.|    |...  . |.   ..
GrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 35-296 1.2e-84 279.2 In-house 15-271 (284) alignment 
Range on Protein: 35-296
Range on HMM: 15-271/284.0
FSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTnivergKLKCQKYW
    ..  ..|| |||. .|.| |...| .  |.|. .|||||| || || ...|.||||||  || .|||||.||. || ||..|      | || .||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PSANPEEYGRLVVTPLEEEELSHYVIRKFciEIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRD--AGPIVVHCSAGVGRTGTYI
|    ....|  |     || . ||.|..  |...   |   |.| |.|.  |||.||| ... |.......|   |.     .|||||||||||||.||
plkivikeerfkvkvdsveeseeyvvrdi..elsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

VLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRI
|||..||.| .|  ||.. ||   | ||| .||  .|| ||. ||.|    |...  . |.   .
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayl
subfamily_PTPN3_pd Subfamily PTPN3 35-280 5.8e-73 240.2 In-house 31-275 (280) alignment 
Range on Protein: 35-280
Range on HMM: 31-275/280.0
FSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDgipGsDYINANFI----DGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKC
 . ... | || .||||..|.. |.||| ..| .     ||||||..    .. .  |..||||||...|  |||.||||. .| |||.|..||||. ||
laisaarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

QKYWPSAN-PEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDvesPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTG
 .|||. .   |||.. |.  .|.| . ||.|..... ....     |.|.|  |.||||||||......| |..|.|.  | .  |.|||||||.||||
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketk...eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtG

TYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
 .|.|.  |  . .. .| .   |.. | || |.|||..|| |. .|.... 
vlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_egg_pd Subfamily egg 35-276 3e-32 106.5 In-house 30-266 (307) alignment 
Range on Protein: 35-276
Range on HMM: 30-266/307.0
FSWDHSLKEENKPKNRYQNI-VADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERgkLKCQKYW
 |  ......|. | | . .  .| .||..    |    |.| || ..|    |.|| .| |. || |||||||..  .  |||.|  .|    .|. ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PSANpEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVESPAREIVQYHYTAWpDHGVPTHATSLLAFIRRIRNSvSRdagPIVVHCSAGVGRTGTYIVL
| |. ..  ..|   |. | |  .        ...  .  . .|     .  . |    ..  | |  .|..||  |.   |.||..  || ...| . .
pkae.sdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnl.sk...pvvvqdilGvskaatlvai

DAMLDQMSKEGA--VDIFGFVSHTRLQRNMMVQTEAQYIFIHDAL
.  | .. .       .   |   ||.|.. |..  .|.|..  .
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv
0040439 (Phosphotyrosine protein) phosphatases II 36-279 1.3e-86 285.5 In-house 2-245 (249) alignment 
Range on Protein: 36-279
Range on HMM: 2-245/249.0
SWDHSLKEENKPKNRYQN-IVADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWP
.....|..|||.||||.. .  ||.|| .| |.| ..||||||..||||.. ..||||||| ..|..|||||.||.|...|||.|. ||.|. ||..|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SANPEEYGRLVVTPLEEEELSHYVIRKFCIEIAnsdVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSR--DAGPIVVHCSAGVGRTGTYIV
. .. |||...|| |..|....|..|.....      ... |.. ...|| ||||||| .  .||.||...|. ...  . ||..||||||||||||.|.
lggsleygdftvtllsvevkddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

LDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
.. ||.|. ||. ||..  |.. | ||...||.. ||.|...||.| 
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 36-280 3.5e-48 158.7 In-house 45-283 (290) alignment 
Range on Protein: 36-280
Range on HMM: 45-283/290.0
SWDHSLKEENK--PKNRYQNIV-ADHTRVAISelDGIPGsDYINANFIDGYNhrNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKY
  . .. ..|    ||||...|  | ||| ..  || .| ||. ||...| .    || |||.. .|  |.|||| ... . |||. ...| || ||..|
ylerkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPSANPE--EYGRLVVTPLEEEELSHYVIRKFcIEIANSDVeSPAREIVQYHYTAWPDHGVPThatSLLAFIRRIRnSVSRDAGPIVVHCSAGVGRTGTY
.|  . |   .| . |.  ||..    .|.|  . . . |       .  ..  .|||. |.    | ||..| .| .. . .||.|||||||.|||||.
ypekeGevltfGeitvlcseeddkdaniikkt.lsvrdkds.Gkehklkhlkikswpdksval...stlallrtlr.ilrkasGpvvvhcsaGiGrtGtf

IVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
. ... |. . .  ..|. . |   |  |   || . ||. . ..|..  
vaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
0037934 (Phosphotyrosine protein) phosphatases II 37-278 6e-80 263.5 In-house 2-240 (243) alignment 
Range on Protein: 37-278
Range on HMM: 2-240/243.0
WDHSLKEENKPKNRYQNIV-ADHTRVAIseldgiPGSDYINANFIDGYNhrnKFIATQGPVSNTFDD----FWRMVWEHGCSCIVMVTNIVERGKLKCQK
. ..|..||..||||..|.  ||.|| .      .||||||||.|....   ..|||||| ..|..|    ||||.||.|...|||.|. ||.|..|| .
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPsaNPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVESpaREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNS--------VSRDAGPIVVHCSAG
|||  ....||...|| |.||.|..|..|....|  . | ..  |....|||..|||||||.. ..||.|.. .|.         .  . ||..||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddlt..rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTYIVLDAMLDQMskeGaVDIFGFVSHTRLQRNM-MVQTEAQYIFIHDALME
||||||.|... ||...   | ||..  | . | ||.. .|||. ||.|...||.|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPRN_pd Subfamily PTPRN 37-278 5.6e-59 194.3 In-house 48-290 (297) alignment 
Range on Protein: 37-278
Range on HMM: 48-290/297.0
WDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRN-KFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWP
 . . .|.|  |||.....  ||.|| ..|      |||||| .|   . |.  .||||||...|  |||.||||.|.  ||..|.. | |  .|..|||
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

SANPEEYGRLVVTPLEEEELS-HYVIRKFCIEIANsdvESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVL
    | |.   |  . |   .  |..| | .   .    | .| . |.|. .||..|||. | ||| | |..  |    . |||||||.|.||||.||..
deGsevyhiyevhlvsehiwcddylvrsfylknlq...tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyili

DAMLDQMSKE-GAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
| .|... |    .||   . | | ||. .|.|..|. |.  |. |
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0042113 (Phosphotyrosine protein) phosphatases II 38-278 1.8e-85 281.5 In-house 2-241 (245) alignment 
Range on Protein: 38-278
Range on HMM: 2-241/245.0
DHSLKEENKPKNRYQNI-VADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA
...|..|||.|||| .|   ||||| .|. .| ..||||||...|||.. .|||||||| ..|..|||||.||.|...|||.|. .|.|. ||..|||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

NPEEYGRLVVTPLEEEELSHYVIRKFCIEIansDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVS-RDAGPIVVHCSAGVGRTGTYIVLDA
.. .||...|| |.|| |..|..|.....    . ... ||...|||. |||||||..  .|| |....|. ..  . ||..||||||||||||.|... 
esltygdftvtllseehlddytvrtlevtn...lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

MLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
||.|. ||. |...  | . | || ..|||. ||.|...||.|
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN14_pd Subfamily PTPN14 38-278 1.4e-52 173.5 In-house 42-294 (300) alignment 
Range on Protein: 38-278
Range on HMM: 42-294/300.0
DHSLKEENKPKNRYQNIVA-DHTRVAISELDGIpGSDYINANFIDGY--NHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWP
. .  .||..|||.....  ...|| .|       ..||||  |      .. ..|..|||. .|  |||.||||.| . |||.|.. | || |. ||.|
staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

SA----NPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVEspaREIVQYHYTAWPDHGVPTHATSLLAFIRRIR---NSVSR------DAGPIVVHCS
.     .  |.|.  ||    |. . .. ... ..   |  |   |...   || |||||||   .. | ......   . ...         |..||||
kleskkktvefgkfkvttkfsedsdsvittglklkhlpskee...rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

AGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|||||||  |. | ..  . ..  .||   ... | || ..||| ||| |....|..
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 39-191 2.2e-13 44.4 In-house 90-235 (244) alignment 
Range on Protein: 39-191
Range on HMM: 90-235/244.0
HSLKEENKPKNRYQ-NIVADHTRVAISEldGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERgklkcQKYWPSAN
 ... .|  |||    .  |  || .|.  |  |  |||| |.       ..| || |...|  |||.|. |     .|..  . |      ..||| ..
dafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse

PEEYGR--LVVTPLEEEELSHyvIRKFCIEIaNSDVESPAREIVQYHYTAWPDHGV
| |.    . ||  . .|.    |.   .|| .||..   . .  .  . ||  | 
plewyeeditvtltdrdefkn..ikasnlei.esdmneshqaltmfqisnwpsdgt
subfamily_PTPN13_pd Subfamily PTPN13 40-279 6.8e-69 227.2 In-house 32-268 (273) alignment 
Range on Protein: 40-279
Range on HMM: 32-268/273.0
SLKEENKPKNRYQNIV-ADHTRVAISELDGipgsdYINANFIDGYN--HRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA
. |.||| ||||.|..  |.||| ...  |     ||||..|      .. ..||.|||. .| .|||.||||  .. |.|||. .|.||.||..|||. 
gkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

NPEE---YGRLVVTPLEEEELSHYVIRKFCIEIANSdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNsVSRDAGPIVVHCSAGVGRTGTYIVL
. ..   ..|| |. |. ..|. .|.|.. ..  .|   . .||... ....|||||||..|..|| |....|. . .||||||||||||.||.||.|..
knkklkvsnrlevellkvqkldgfvvralavkdses...gesrevahlnfvkwPdhgvPssaaellqfvaevrr.lqtdagPivvhcsaGiGrsGtliti

DAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
|..|. ....  .|.   | . | ||. .|||. ||||.. |..|.
dvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 42-289 3.8e-84 276.8 In-house 6-245 (250) alignment 
Range on Protein: 42-289
Range on HMM: 6-245/250.0
KEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLkCQKYWPSANPEE
| .|| |||| .|.| |..|| . . .|   |||||| |..||. |. |||||||...|. ||||||.|.  . |||.||..| .|  ...|||  ..|.
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YGRLVVTPLEEEELSHYVIRKFCIEianSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSR-DAGPIVVHCSAGVGRTGTYIVLDAMLDQ
|| . |..|..|| . |..||. .    .  ..  | ..|.|...||| ||| .||. |....... |  . ...|..|.|||||||.|..|..||.|..
yGdvtvsllskeefadytkrklkls...kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCgntefkV
. ||  ||.| ..   | .|  .|....||.|.. ....| ..      |
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......v
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 42-279 6.2e-67 220.2 In-house 4-239 (239) alignment 
Range on Protein: 42-279
Range on HMM: 4-239/239.0
KEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNK-FIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANpE
|  || |||| |||. ||.|| . .|   | ||||||...  |.   | .||||| |. .  |||||.|.     |||.| ..|  | ||..||| .   
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.s

EYGRLVVTPLEEEELSHYVIRKFCIEIANsdvESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQ
.|  | ||  . | .. |.|| | .       ..  | . |||.| |||.||| .||..| . |.| .     | | |.||||||||||...|.|||| |
kycnlrvtlrktevfadyiirtfvmsqvg...qteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
  |. .|||| .|   | .|  ||||  ||.||| |..||
akkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 42-278 1.9e-66 218.7 In-house 5-239 (239) alignment 
Range on Protein: 42-278
Range on HMM: 5-239/239.0
KEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNK-FIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANpE
|  || |||| |||. ||.|| . .|   | ||||||...  |.   | .||||| |. .  |||||.|.     |||.| ..|  | ||..||| .   
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.s

EYGRLVVTPLEEEELSHYVIRKFCIEIANsdvESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQ
.|  | ||  . | .. |.|| | .       ..  | . |||.| |||.||| .||..| . |.| .     | | |.||||||||||...|.|||| |
kycnlrvtlrktevfadyiirtfvmsqvg...qteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
  |. .|||| .|   | .|  ||||  ||.||| |..|
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN23_pd Subfamily PTPN23 43-281 1.8e-56 186.1 In-house 41-281 (288) alignment 
Range on Protein: 43-281
Range on HMM: 41-281/288.0
EENKPKNRYQNIV-ADHTRVAISeldgIPGSDYINANFIDGYNH-RNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA--NP
. .  |||...|.  ||.|| .         ||||| |. .      .|||||.|  .|  |||.||.|   | |||...  |.|| |...|||..  ..
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

EEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVespAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRN---SVSR-DAGPIVVHCSAGVGRTGTYIVLD
...| | ||  ...|....| |.. .|. ..|     ....  ..|.||..|||    .||.|.  ...   .| |    |.||||||||||||.. .. 
vkfgdlsvtlksvretethvervlkletldada...vksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvy

AMLDQ-MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAK
| . .   ..| .||   ||. | ||  |||...|. |  .| .|||.
aavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 43-278 6.9e-36 118.3 In-house 35-267 (281) alignment 
Range on Protein: 43-278
Range on HMM: 35-267/281.0
EENKPKNRYQNIV-ADHTRVAISE-LDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANpee
  |. |||| ||   | .|| .   .     .||| ||.|     .  .| ||||  .|  |||||.|.   ..|||. ...|  . || .|.|      
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna...

YGRLVVTPLEEEELSHYVIRKFCIEIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNsvsRdAGPIVVHCSAGVGRTGTYIVLDAMLDQM
.  | .  |  .     | . .     |   |  .| | .. .  |||  ||  .  .|  .|.||    | . | |.||||||||.|| . ..  |. .
hcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira...r.stppvihcsagvgrsgtlmaveialqsi

SKE-GAVDIFGFVSHTRLQ-RNMMVQTEAQYIFIHDALME
       ||   ||| |.  |   |||  ||..|   |..
hshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 43-279 2.1e-28 94.1 In-house 33-269 (285) alignment 
Range on Protein: 43-279
Range on HMM: 33-269/285.0
EENKPKNRYQNIV-ADHTRVAISELDgipgSDYINANFIDGY-NHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE-
| |   ||| ..   . ||| . . |     ||| |...    . .. .|.||||. .|. |||.|...   . ..|.  ..| |  ||  |.|    | 
eanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-EYGRLVVT--PLEEEELSHYVIRKFCIeIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNsVSRDAGPIVVHCSAGVGRTGTYIVLDAM
 ..|.  .|    .|| ..  ..  . . |   |  |    . . .   |||.  |  |  .. . . ... |     ||.|||||||||| |.. .|  
vkfgkyeitlteckeeaiagtilnaltv.intedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidya

LDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
  .. ..  ....  |   |  |   ||.  |..|..  ||| 
tirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 44-278 7.6e-70 229.8 In-house 2-237 (237) alignment 
Range on Protein: 44-278
Range on HMM: 2-237/237.0
ENKPKNRYQNIVA-DHTRVAISELDGipGSDYINANFIDGYNHR-NKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN-PEE
||| |||| |||| ||.|| .    .  |||||||....|..   .|.||.|||. .. ||||.|||.  || |||.| ..|. .||| |||||.. |. 
enkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGRLVVTPLEEEELSHYVIRKFCIEIANSDVesPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSR--DAGPIVVHCSAGVGRTGTYIVLDAMLD
|| | |.   .||.| | .| . .    .      | | ||..|.|||.||| ....|| | ..| |      ..|| ..|||||||||| ..|.|||| 
ygvltvslkkkeefsdytvrslllskrltlk..evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|  ..  |||. .|     .|  ..||. ||.|||....|
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 44-277 5.5e-41 135.2 In-house 54-286 (305) alignment 
Range on Protein: 44-277
Range on HMM: 54-286/305.0
ENKPKNRYQNIVADHTrvAISELDGIPGSDYINANFIDGYN-HRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYG
 .. |||||.. ..    ..  ||  . |||| ||..       ..||..|||. .| |.|| || ..    |||. . || ||||| .||| |. |   
iaitknryqdvpcqdq..savkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

RLVVTPLEEEELSHYVIRKFCIEIANSDVES---PAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSvsrdAGPIVVHCSAGVGRTGTYIVLDAMLDQ
      .|.   |. . |   |.|.  ..         . . ..| ||| |||    . | ..  || |      |||||||||.||||| . .. .|..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs....kvpivvhcsagigrtgtivaieyilek

MSKEGAV-DIFGFVSHTRLQRNMMVQTEAQYIFIHDALM
....  .  .  .|   | || . .|.. ||.|||  ..
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvml
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 44-285 1e-36 121.1 In-house 51-294 (310) alignment 
Range on Protein: 44-285
Range on HMM: 51-294/310.0
ENKPKNRYQNIVA-DHTRVAIsELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN-PEEY
..  |||| ..|  | .|| . ..|     ||| ||..     |. || .|||.  |  |||||...  .  |... ...| |. ||  ||||    | |
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GRLVVTPLEEEElSHYVIRKFCIEIANSDV---ESPAR----EIVQYHYTAWPDHGVPTHATSllAFIRRIRNSVSrdAGPIVVHCSAGVGRTGTYIVLD
| . || | |     . | .... .   .|   | ||      .   ..  ||| |||       .  .|.   |    || |||||||..|... . |.
gcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch..tvpqrllaqvr..hgpcvvhcsagkdrlyvvvalk

AMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKcGNT
  .|.. .   ||.   ... . .| . .||| ||..|.   .  |. |.|
lkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar.get
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 44-298 4.7e-18 60.3 In-house 18-277 (290) alignment 
Range on Protein: 44-298
Range on HMM: 18-277/290.0
ENKPKNRYQNIVADHTRVAISELDGIPGSDYINANFIDgYNHRNKFIATQGPVSNT-------FDDFWRMVWEHGCSCIVMVTNIVERGKL----KCQKY
... ..|... .. .|||.. .      .||| ||..  . .  ..|.|| |  ..         .|| |. .     .||. .  |. .      |.||
khemdqRlevpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WPSANPEE--YGRLVVTPLEEEELSHYVIRKFCIEIANSdvesPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSvsrdAGPIVVHCSAGVGRTGTY
 | .  ||  .. | |   . |.     .|. ...  .         .  . .  | .  |. .  .||. |. ...|      |..|||  |. |  . 
vpesvgeelkfkgltvkCkskekeddvetRelvvkfdde....eeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAal

IVLDAMLDQMS-KEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKA
  ..     .  ..|.| .   ..  | ||....... .. |.  ...  |.    .|  .. . ..||
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkaka
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 44-278 1e-17 58.7 In-house 46-277 (303) alignment 
Range on Protein: 44-278
Range on HMM: 46-277/303.0
ENKPKNRYQNI-VADHTRVAISEldgipgSDYINANFIDgYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANP---E
.|  |||. .. . ||..| .|.      | || |....  . ..| | || |.| |  |||.|. |    |....    |  ||  .  .|  .     
knmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

EYGRLVVTPLEEEELSHYVIRKfCIEIANSDVESparEIVQYHYTAWPDHGVPTH-ATSLLAFIRRIRNSVSR--DAGPIVVHCSAGVGRTGTYIVLD-A
|   . |  . . ||..    |  . ..| |  |    .  .|| |||   .|.. .  ..  | ...  . .  |. | |    .|.||.||. ... |
eersirvgefkrvelgdgwvlk.vlsvsngdyks...flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

MLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
 |   |.. ..|.   .   |  |   ||  .|. ...  | |
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
Y_phosphatase Protein-tyrosine phosphatase 45-278 1.6e-83 275.1 Pfam-A 1-235 (235) alignment 
Range on Protein: 45-278
Range on HMM: 1-235/235.0
NKPKNRYQNIV-ADHTRVAIselDGIPG-SDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWP--SANPEE
|| ||||..|. .|.||| .   .| .| |||||||...||.. .||||||||...|..|||||||.. ...|||.|. .|.|. ||..|||  . ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGRLVVTPL-EEE-ELSHYVIRKFCIEiaNSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLD
||.. |.   .|. . ..|..||. ..  ... ||  ||. |.|||.|||||||....||| .||....| . . ||.|||||||||||||...||..|.
ygdikvelkekekedekeytlrklelk..kkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|...|. ||.. .|.. | ||..|||...||||...|..|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 45-278 1.6e-83 275.1 In-house 1-235 (235) alignment 
Range on Protein: 45-278
Range on HMM: 1-235/235.0
NKPKNRYQNIV-ADHTRVAIselDGIPG-SDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWP--SANPEE
|| ||||..|. .|.||| .   .| .| |||||||...||.. .||||||||...|..|||||||.. ...|||.|. .|.|. ||..|||  . ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGRLVVTPL-EEE-ELSHYVIRKFCIEiaNSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLD
||.. |.   .|. . ..|..||. ..  ... ||  ||. |.|||.|||||||....||| .||....| . . ||.|||||||||||||...||..|.
ygdikvelkekekedekeytlrklelk..kkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|...|. ||.. .|.. | ||..|||...||||...|..|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 45-280 1e-63 209.8 In-house 20-264 (270) alignment 
Range on Protein: 45-280
Range on HMM: 20-264/270.0
NKPKNRYQNIVAD-HTRVAISELDGIPGSDYINANFIDGYNHR-NKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE---
.|  |||..|. . .||| ..||.  . . |||||.. |.... .|.||..||. .|  .||||.||.  ..|||.|...|.|. ||..|||. . |   
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-EYGRLVVTPLEEEELSHYVIRKFCIEiANSDvespAREIVQYHYTAWPDHGVPTHAT------SLLAFIRRIRNSVSRD--AGPIVVHCSAGVGRTGTY
 |.| . |. |.||  . |....  .|  ...     |..| ..|..|||||||...       .||. .| .|.| ..   |.|..|||||||||||| 
ledgkikvlalseekeegyiltrlrle.ekge....errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

IVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
|.|| ..  ..... ||.   ... | .|  .||.  || |.. |..| |
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
0041856 (Phosphotyrosine protein) phosphatases II 45-288 9.1e-56 183.6 In-house 1-179 (182) alignment 
Range on Protein: 45-288
Range on HMM: 1-179/182.0
NKPKNRYQNIVADHTRVaiseldgipGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTnivergklkCQKYWPsanpeeygrl
|..||||..|.  .            ..||||||...|. . ..|||||||  .|. ||.||..|.|...||..|         .  |||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

vvtpleeeelshyvirkfcieiansdvESPAREIVQYHYTAWPDHGVPThATSLLAFIRRIRNsvsrDAGPIVVHCSAGVGRTGTYIVLDAMLDQmskeG
                           |   |...||.|. |||||||.   .||.||.....    . ||..||||||||||||..... |. .    |
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g

aVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFK
 |...  |.. | .|..||.|. ||.|...||.|  ....|. |
.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 45-281 1.5e-54 179.7 In-house 38-278 (287) alignment 
Range on Protein: 45-281
Range on HMM: 38-278/287.0
NKPKNRYQNIV-ADHTRVAISElDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA-NPEEYG
.  |||| ...  |.||| .|. .|  ||||||||.. .|.. ..|||.|||.. |  ||||.|.|.  . ....|  || ..||| ||||    |   |
avkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

RLVVTPLEEEELS-HYVIRKFCIeiANSDVESpAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNS--VS---RDAGPIVVHCSAGVGRTGTYIVLDAM
   |. |. . .. .| .| . .  .. . .  || . |... .|||....  | .|. |.  ...   ..    ..||.|||...|.||.|... . ..
GysvvlldydikePeygvralrl..idletre.arvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAK
.... . | ||.   | . | .|. .||.  |. .. .||.   |
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 45-278 6.5e-37 122.1 In-house 43-269 (288) alignment 
Range on Protein: 45-278
Range on HMM: 43-269/288.0
NKPKNRYQNIV-ADHTRVAISelDGipGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEE--Y
|  ..||.|.   | ||| .|  |      ||.|| .   ......| .| |.  | . .|.|. | .   |||.....|.|| | ..|.||   |.  .
nptrdryenlprcditrvkls..dd..pdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GRLVVTPLEEEELSHYVIRKFCIEIanSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSvsrdAGPIVVHCSAGVGRTGTYIVLDAMLDQMS
|||     .. .  . ...   . |  | .   .  . . |.  |.|.|||    | | .. ....       |||||.||||||||| |.   .|... 
grlctvvkkkradidklvkvsllri..skegeekvivkilhlleWdddgvPenylsplrllevlksl....qkPivvhssaGvGrtgtlililialeslr

KEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
 .  . |  .... | .|   .||| ||...|  ..|
lddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_CG42327_pd Subfamily CG42327 45-209 8.9e-29 95.1 In-house 28-194 (319) alignment 
Range on Protein: 45-209
Range on HMM: 28-194/319.0
NKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNH-RNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA----NP
 |.|.|. |.|   .|||   .    . . |..|... ||.  .| .||.| .  ..  ||||.|||     || .|.. | |  .| .|.|.     | 
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

EEYGRLVVTPLEEEELSHYVIRKFCIEiaNSDvESPAREIVQYHYtAWPDHGVPTHATSLLAFIRRIRNSV
. || . ||  . |   .|.|  . .   . | .. .||.  | |  |.. .||.. ..|.| . ..|.|.
slyGdilvtlkgrevkdryaistlllk..rvd.keesrelthywy.kwleaevPaeeaaliamllevrssl
subfamily_eak_pd Subfamily eak 45-203 1.5e-09 31.7 In-house 52-205 (332) alignment 
Range on Protein: 45-203
Range on HMM: 52-205/332.0
NKPKNRYQNIVADHTRVAISELDGiPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE--EYG
.  .| .. .  |.  | ..         ||||  ..  .  .|.| |  .  .    ||.|| |    .||.. . || .  | .||.|    |  ..|
avnrnvvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfG

RLVVTPLEEEELSHYVIRKFCIEIANSdvespAREIVQYHYTAWPDHGVPTHaTSLLAFIR
 | |.  |  . . .  |.. ..  |      . ..  |..  | .  .|     .||. .
ildverkefvkrniletrllelskGne.....thrvlhykvfGwtettlpky.edflalrk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 46-272 5.8e-38 125.3 In-house 51-273 (301) alignment 
Range on Protein: 46-272
Range on HMM: 51-273/301.0
KPKNRYQNIVADhTRVAISEL---DGIPgsdyINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEE--
| |.||...  .    |.  .     .|    | ||.|.   | ..|||||||..|| .||| |.  .    |||... ||. . ||..| |.  .|.  
kdkhryptvPck.PstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGRLVVTPLEEEELSHYVIRKFCIEIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSvsrdAGPIVVHCSAGVGRTGTYIVLDAMLDQM
 ||  ..  ..| . .  | |  .|...|  . ..| .. | |. |.|.|||   . |  ..  ...|      |||||||||.||. ..|  . .  ..
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteylarev

SKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFI
  .  ...   . | | .|   |||. |  ..
eadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 46-279 1.5e-28 94.4 In-house 44-275 (312) alignment 
Range on Protein: 46-279
Range on HMM: 44-275/312.0
KPKNRYQNIV-ADHTRVAISELDgipgSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN---PEEY
|  ||| ||   |  | ...  .      || |||.    . ..|..||||. ||   ||...   |...|.... .|| |  || ||          | 
kdlnrypniqcwdrgrftlagde....nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

GRLVVTPLEEEELSHYVIRKFCIEIANSDVESPARE--IVQYHYTAWPDHGVPTHATSllafIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQ
 |.      | |.      |    . .  | .  .|  . .| ...|||||.|    .      |.  .| .|  |.. ||||||||||| .....|.  
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdt....alrllsavkkdkkpviahcsagvgrtgtlaliesmiaa

MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
. .    ..       | .|   |.. .||..   ...| 
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 46-139 6.6e-20 66.1 In-house 48-156 (350) alignment 
Range on Protein: 46-139
Range on HMM: 48-156/350.0
KPKNRYQNIVA-DHTRVAIS--------ELDGIPGSDYINANFIDGY------NHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQ
  ||||.||.  .|.|| .             . ..||||||..         |   |.||||.|. .|.|||.... . .   |...|. || .  ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

KYWPSANPE
.||.  . .
rYWqegsyd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 47-277 3.5e-20 66.6 In-house 53-282 (302) alignment 
Range on Protein: 47-277
Range on HMM: 53-282/302.0
PKNRYQNI-VADHTRVAISELDgipgSDYINANFIDGYNHRNKFIATQGPVSNTF---DDFWRMVWEHGCSCIVMVTNIVERGKlKCQKYWP--SANPEE
 ||. ... ..|...| ...       .|.||  ..  . ... | .| |....    ..|||||... .  .|..    |  |   ....|  | . .|
kknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyke

YGRLVVTPLEEEELSHYViRKFCIEIANSDVE-SPAREIvqYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQ
||.. |     |. .  .  ...||.   ..  |.  ..  |. | |... ||.. ..| . .  . .. .    ..|.    |.|| |. ..| . ...
ygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanv..yvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavek

MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALM
. |. .. |   |   | ||  .|..  ||.... ||.
lqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 50-166 3.5e-11 37.1 In-house 39-157 (332) alignment 
Range on Protein: 50-166
Range on HMM: 39-157/332.0
RYQNI-VADHTRVAISELDGIpgSDYINANFIDGYNHRNKFIATQGPVSNTF-DDFWRMVWEHGCSCIVMVTNIVERGKLKCQkYWPSANPEEY---GRL
|   . . ||.|| ..  ||    |. ||...|||.... .| .| |. .     ||||| |.  | |... .| |. | |.  |  |    |      .
riphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap.ydisdrgfeksflhef

VVTPLEEEELSHYVIRKFCIEI
    ||| ||   . |||  | 
gaksleecelkakicrkfwpek
0044763 (Phosphotyrosine protein) phosphatases II 57-279 5.6e-42 138.7 In-house 3-170 (178) alignment 
Range on Protein: 57-279
Range on HMM: 3-170/178.0
DHTRVAISELDGIPGSDYINANFIDGYnhrnKFIATQGPvsntfDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPeeygrlvvtpleeeelsh
|.||| .|.| |...||||||..|...     ......|      |......|.|...||..|. .|.|.||| .|||. .                   
drtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

yvirkfcieiansdvespareiVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQmskegAVDIFGFVSHTR
                      .||... .||||||.    .|.|.. |.. .... ||..|||||||||.|| .... |. .      ....  ... |
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

LQRNmMVQTEAQYIFIHDALMEA
 .|. .|... |. ....  .. 
erRp.ivpnpgqlrqLyefelrl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 62-137 2.5e-12 40.8 In-house 80-157 (349) alignment 
Range on Protein: 62-137
Range on HMM: 80-157/349.0
AISELDGIPGSDYINANFID--GYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN
. || |.    ||||||..    ..  .|.|||| |.  | |||....   |   .. ...  | .  ||..||   .
stsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 65-191 8.1e-13 42.8 In-house 6-126 (130) alignment 
Range on Protein: 65-191
Range on HMM: 6-126/130.0
ELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERgklkcQKYWPSANPEE-YGRLVVTPLEEEELSHYvIRKFC
|.. ..| .||||.|.   .. .... || |...|  |||.|. |     .|..  . |      ..||| ..| | |   ..  | . . ... |.   
evsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkn.ikasn

IEIaNSDVESPAREIVQYHYTAWPDHGV
.|| .||.    . .  .. . ||  | 
lei.esdlneshqaltmfqisnwpsdgt
0051429 (Phosphotyrosine protein) phosphatases II 69-280 1.5e-62 206.9 In-house 1-225 (272) alignment 
Range on Protein: 69-280
Range on HMM: 1-225/272.0
IPGSDYINANFIDGYNH---RNKFIATQGPVSNTFDDFWRMvWEHGCSCIVMVTNIVERGKLKCQKYWP------------SANPEEYGRLVVTPLEEEE
.| |.||||....||..   ........||  .| .||||. .|.|...||.... .|||.||| .|||            || . .||.|.|| |.|| 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LSHYVIRKFCIEIANSDVESpaREIVQYHYTAWPDHGVPTHAtsLLAFIRRIRNsvsrdAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVD------
|..|..|......  |  |.  ||. ..|||.|||||||..|  ||.... ...      ||..||||||..||||...|. .| ..|.|  ||      
lldyilrellltlllsagea..revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--IFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
  ....|.. | ||  .||||.||.|...||.|..
lyleeaveelraqrpgavqteeqylflyeallell
0046846 (Phosphotyrosine protein) phosphatases II 69-278 3.2e-49 162.3 In-house 9-171 (176) alignment 
Range on Protein: 69-278
Range on HMM: 9-171/176.0
IPGSDYINANFIDGYnhrnKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYgrlvvtpleeeelshyvirkfcieian
 ...||||||.|.|.    ..||||||. .|. ||..|..|.|....|..|. || |.|||  |||    ...                           
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

sdvespareivQYHYTAWPDHGVPTHaTSLLAFIRRIRNSVSRDaGPIVVHCSAGVGRTGTYIVLDamldQMSKEGAVDIFGFVSHTRLQRN-MMVQTEA
           ||... |||||||.. . || ... ||. .... ||..||||||.|||||.....     . .|  ....  ... | ||  ..|||..
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYIFIHDALME
|| |.......
Qyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 70-273 7.6e-51 167.5 In-house 3-154 (172) alignment 
Range on Protein: 70-273
Range on HMM: 3-154/172.0
PGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIvergklkcqkywpsanpeeygrlvvtpleeeelshyvirkfcieiaNS
.|||||||...|.| . ..||||||| .||..|||||..|.|...||..|.                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................ly

DVESPAREIVQYHYTAWPDHGVPtHATSLLAFIRRIRN-SVSRDAGPIVVHCSAGVGRTGTYIVLDAMLdqmskeGAVDIFGFVSHTRLQRNMMVQTEAQ
| |   |...||.|. ||||||| ..  || |.. |..  . .. ||..|||||||||||| .... ||        ....  |.. | .|...||.. |
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YIFIH
|.|..
yrfly
0036282 (Phosphotyrosine protein) phosphatases II 71-274 1.5e-55 182.9 In-house 1-164 (174) alignment 
Range on Protein: 71-274
Range on HMM: 1-164/174.0
GSDYINANFIDGYNHRNKFIATQGPVSntfddFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSanpeeygrlvvtpleeeelshyvirkfcieiansD
|||||||...|..   ...||.||| .     ||.|..|.|....||... .|.|. ||  |||.                                  .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................l

VESPAREIVQYHYTAWPDHGVPTHATsLLAFIRRIRNSVSR-DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSkEGAVDIFGFVSHTRLQRNMMVQTEAQY
 |.. |...||.|. |||||||. .. || |...... .|. . ||..|||||||||||| .... || ..  |..||.. .|   |||| .||||. ||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

IFIHD
.|...
rflyy
0051082 (Phosphotyrosine protein) phosphatases II 71-276 5.9e-41 134.9 In-house 2-149 (151) alignment 
Range on Protein: 71-276
Range on HMM: 2-149/151.0
GSDYINANFIDGYnhrnkFIATQGPvsntFDDFWRMVWEHGCSCIVMVTNIVERGklKCQKYWPSANpeeygrlvvtpleeeelshyvirkfcieiansd
 |||||.....|.     .....||     .||.....|.|...||.... .|||  .| .|.|...                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

vespaREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNsvsRDAGPIVVHCSAGVGRTGTYIVLDAMLdQMskegaVDIFGFVSHTRLQRNMMVQTEAQYI
     .|....... |||.|.|..  ..|.|.. ...    . ||..||||||.||||| ..|. || ..     |...  ... ||.| ..||.. |..
.....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqfl

FIHDAL
|.. ||
fqlfal
0049260 (Phosphotyrosine protein) phosphatases II 79-274 1.3e-48 159.8 In-house 1-144 (152) alignment 
Range on Protein: 79-274
Range on HMM: 1-144/152.0
FIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWpsanpeeygrlvvtpleeeelshyvirkfcieiansdvesparei
|||||.. ..||||||| .||..|||||..|.|...|||.|. .|.||||| .|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

vQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLdqmskeGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHD
 ||... |||||||...  || ... |.    .. ||..||||||||||||..... ||        |... .|.. | .|...|... |..|...
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 80-274 1.2e-23 78.0 In-house 83-286 (302) alignment 
Range on Protein: 80-274
Range on HMM: 83-286/302.0
IDGYNHRNKFIAT-QGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE--EYGRLVVTPLE-EEELSHYVIRK----FCIEIANSDV
.|| ....|       |  .| . .| .. ..  . .| ....|| .. || .|.     .  ..||  |. .. ...|...  .|    . .|| |. .
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

ESPAREIVQ-YHYTAWPDHGVPTHATSLLAFIRRIrNSVSRDagpIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYI
..  .  |.  ...|||||| | .| . |  ..   .|  ..   ..|||||||||||| . .   ..  ||.   |.   |   |  |   ||.| | |
kkkvkktvdilafsawpdhGapkeaytaldilkfc.esykkn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

FI----HD
..      
ylllcvtk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 81-136 2.4e-10 34.4 In-house 230-282 (440) alignment 
Range on Protein: 81-136
Range on HMM: 230-282/440.0
DGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERgklKCQKYWPSA
.|| ..| ||||| |.  |  ||||.| ..  | |.|. .. ..    |  |||  
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvn
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 86-273 6.6e-25 82.4 In-house 4-197 (199) alignment 
Range on Protein: 86-273
Range on HMM: 4-197/199.0
RNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN--PEEYGRLVVTPLEEEELSHYVIRKFcIEIANSDVESPAREIVQYHY
. ..|||| |. .|. |||.|||| |   |||| .     .     |||...    .|| | ||       . |.|  . |   |.     .||| .| .
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital.iltnnttappstreishyqf

TAWPDHGVPTHATsLLAFIRRIRNS---VS-RDAGPIVVHCSAGVGRTGTYIVLDAML--DQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIH
|.| ..  |  |  .. |.   |.           |..|||| | | || .. ||  .   . ||   ||.|      |  |  .. .  .| ||.
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 87-273 7.7e-25 82.2 In-house 4-196 (198) alignment 
Range on Protein: 87-273
Range on HMM: 4-196/198.0
NKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN--PEEYGRLVVTPLEEEELSHYVIRKFcIEIANSDVESPAREIVQYHYT
 ..|||| |. .|. |||.|||| |   |||| .     .     |||...    .|| | ||       . |.|  . |   |.     .||| .| .|
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital.iltnnttappstreishyqft

AWPDHGVPTHATsLLAFIRRIRNS---VS-RDAGPIVVHCSAGVGRTGTYIVLDAML--DQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIH
.| ..  |  |  .. |.   |.           |..|||| | | || .. ||  .   . ||   ||.|      |  |  .. .  .| ||.
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 97-271 3.7e-20 67.1 In-house 38-212 (255) alignment 
Range on Protein: 97-271
Range on HMM: 38-212/255.0
SNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDvESPAREIVQYHYTAWPDHGVPTHAT
| | | |....   . . .||...  | |. ||..|.|    |      |.    .  .. |.|   |    ..    ....  |.|. |...  |  | 
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlge.kkkthtvkhysykGWieknaPelar

SLLAFIRRIRNSvsRdagPIVVHCSAGVGRTGTYIVLDAMLDQM------SKEGAVDIFGFVSHTRLQRNMMVQTEAQYIF
 .|  .. .|.|  .   ..|||||.|.||. .... . .  .|      .. . .|   .. ..| .|.  ..|  |  |
eilnilkvvrds..k...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_hpo-7_pd Subfamily hpo-7 98-292 2.2e-16 54.5 In-house 45-243 (263) alignment 
Range on Protein: 98-292
Range on HMM: 45-243/263.0
NTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDvESPAREIVQYHYTAWPDHGVPTHATS
.| | |....   . . .||...  | |. ||..|.|    |      |.    .  |  ...   .    ..     ... .| |. |...  |. | .
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekndpelare

LLAFIRRIRNSvsRdagPIVVHCSAGVGRTGTYIVLDAMLDQ------MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIF----IHDALMEAAKCGNTEF
 |  ..  |||  .   ..|||||.|.||.  . | . .  .       .. . .|   .. ..| .|.  ..|  |  |    . | ....   |. | 
ilnilkvarns..k...slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgelea

KVQDL
| |..
kyqei
subfamily_PTEN_pd Subfamily PTEN 149-272 1.4e-08 29.9 In-house 54-172 (184) alignment 
Range on Protein: 149-272
Range on HMM: 54-172/184.0
LEEEELSHYVIRKFCIEIaNSDVESPAREIVQYHYTawpDHGVPThATSLLAFIRRIRNSVSRDAGP-IVVHCSAGVGRTGTYIVLdAMLDQMSKEGAVD
||..   || |  .. |  . | ..   .. .|  .   ||  |.    | .... |.. ...|    .|||| || ||||. ||   .| ..  | | .
lekkhkdhykiynlrser.kydskkfdgrvavypfd...Dhnppp.lelleeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaee

IFGFVSHTRLQRNMMVQTEAQYIFI
.  . ...| . .  |.  .|  ..
alelfaeaRtknkkgvtiPsqrRYv
subfamily_VSP_pd Subfamily VSP 149-271 2.9e-07 24.6 In-house 68-190 (212) alignment 
Range on Protein: 149-271
Range on HMM: 68-190/212.0
LEEEELSHYVIRKFCIEIANsDVESPAREIVQyhyTAWPDHGVPTHaTSLLAFIRRIRNSVSRDAGPIV-VHCSAGVGRTGTYIVLDAMLDQMSK--EGA
|..    || .   | | |  | .   .....       || ||.    || | ..... ...|   .. .||  | ||||| .    .  .. .  . .
ldtkhrdhykvvnlcseray.dekyfnnrvkr...iliddhnvpkl.eellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakes

VDIFGFVSHTRLQRN--MMVQTEAQYIF
.| ||     . . .    ||| .|. .
ldyfgerrtdktegekfqGvqtpsqkry
0048076 (Phosphotyrosine protein) phosphatases II 153-277 4.4e-29 96.4 In-house 24-140 (145) alignment 
Range on Protein: 153-277
Range on HMM: 24-140/145.0
ELSHYVIRK-FCIeiaNSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDaGPIVVHCSAGVGRTGTYIVLDAMLDqmskEGaVDIFGF
.| .. |.  ...    |. | . |...||.|. |||||||. .  ||.|.. |.. .... ||..||||||||||||..... ||     .| |...  
llkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleea

VSHTRLQRNMMVQTEAQYIFIHDALM
. . | || ..|... |..|......
lelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 156-274 6.3e-29 95.9 In-house 30-139 (144) alignment 
Range on Protein: 156-274
Range on HMM: 30-139/144.0
HYVIRKFCIEianSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDaGPIVVHCSAGVGRTGTYIVLDAMLdqmsKEGaVDIFGFVSHT
.. .  .. |    . |.. ||..||... |||||||.... ||.|.. |.. .... ||..||||||||||||..... |.    |.| ....  . . 
ittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalv

RLQRNMMVQTEAQYIFIHD
| .| ..|... |..|...
rsrrpgavpnpgqlrfLle
PTEN_1 162-229 4.1e-10 34.8 In-house 74-146 (196) alignment 
Range on Protein: 162-229
Range on HMM: 74-146/196.0
FCIEIAN----SDVESPAREIVQYHYTAWPDHGVPTHAtSLLAFIRRIRNSVSRD--AGPIVVHCSAGVGRTGT
.. | ..     | |.  .. |.|.   ..|||.|. . .|....... .....|   . ..||| ||.||.||
lseeeelsgrsydleeffksgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 165-277 1.2e-14 48.8 In-house 208-341 (350) alignment 
Range on Protein: 165-277
Range on HMM: 208-341/350.0
EIANSDvespAREIVQYHYTAWPDHGVPTHATSLLAFIR----RI-----RNS-VSRDAGPIVVHCSAGVGRTGTYIVLDAMLD-----QMSKE------
..| ||      .. | ..  |.| ..  .  |.|  .      |     ..   .  . ||.||||||||||||.. || .|      .. ..      
tlaasd....PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkld

----GAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALM
        |.  | . | ||  |||.  |.|||..||.
vaaktrDlisiivnelrkqrismvqnldqfifiYeall
0038934 (Phosphotyrosine protein) phosphatases II 168-251 4.9e-11 38.1 In-house 69-154 (194) alignment 
Range on Protein: 168-251
Range on HMM: 69-154/194.0
NSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDA-GPIVVHCSAGVGRTGTYIVLDAML-DQMSKEGAVDIFGF
  |.|   .  ..|.   .||.|..     || |.. .   ...|. | ..||| ||.||||| ..   .   .|| | |...| .
yYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfre
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 170-278 2.1e-10 34.5 In-house 213-342 (349) alignment 
Range on Protein: 170-278
Range on HMM: 213-342/349.0
DVESPArEIVQYHYTAWPDHGVPTHATSLLAFIRrIRNSV-----------SRDAGPIVVHCSAGVGRTGTYIVLDAMLD--QMSKEGAVD---------
.||.|  |..|  .  |.| ..     |.|  .  ..| .           . .  ...|||||| ||||... || .|.  .. ..  .          
avekPy.ellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkD

-IFGFVSHTRLQRNMMVQTEAQYIFIHDALME
 |.  | . | ||  |||  ||.|.|..||..
lisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_PTPDC1_pd Subfamily PTPDC1 172-274 1.7e-09 32.4 In-house 76-170 (182) alignment 
Range on Protein: 172-274
Range on HMM: 76-170/182.0
ESPAREIVQYHYTAWPDHGVPTHaTSLLAFIRRIRNSVSRDagPIVVHCSAGVGRTGTYIVLDAML-DQMSKEGAVDIfgfvshTRLQRNMMVQTEAQYI
|. ... . ..  .|.|.||..  ...|  .. .  .....   . ||| || ||||  |    .  .... | |...       | .|   .||  |  
ealmeqgiyvynfgwkDygvasl.eriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaikl......vrskrpksiqtreqve

FIHD
....
lvke
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 175-317 1.5e-31 104.2 In-house 88-231 (440) alignment 
Range on Protein: 175-317
Range on HMM: 88-231/440.0
AREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSR-DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIH
.| . |||| .|||.|||  |  .| .|. . .|  .   ||..||||||.||||  |..|..| .  .   .||| |..  | .|  ||||  || |.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DALMEAAKCGNTEFKVQDLHDRIKALQSRDPDSGETYIAKEFKN
.|..|.  ||.|    .|. .|.. .|  .| . .. . .||. 
eavlegllcgdtliledditerveqiqwpnphtdksplqqefeg
PTPc_DSPc_SM00012 178-278 4.1e-37 121.9 In-house 2-105 (105) alignment 
Range on Protein: 178-278
Range on HMM: 2-105/105.0
IVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDA--GPIVVHCSAGVGRTGTYIVLDAMLDQMSKE-GAVDIFGFVSHTRLQRNMMVQTEAQYIFIHD
. .||||.|||||||....|.| ..| .... .  .  .|.|||||||||||||...|| .|.|..|| . |||| .|.. | ||. |||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALME
||.|
alle
PTPlike_phytase Inositol hexakisphosphate 179-237 1.1e-06 23.3 Pfam-A 93-148 (149) alignment 
Range on Protein: 179-237
Range on HMM: 93-148/149.0
VQYHYTAWPDHGVPTHAtSLLAFIRRIRNSvSRdAGPIVVHCSAGVGRTGTYIVLDAML
|.|.  . .|.  |...  . ||.| |... .|    .|..|.|| ||| |..|.  .|
vkYvRipitdeqapeee.dvDafvrliksl.pr.dtalvfnCqaGrgRTTtamviadLl
PTPlike_phytase Inositol hexakisphosphate 179-237 1.1e-06 23.3 In-house 93-148 (149) alignment 
Range on Protein: 179-237
Range on HMM: 93-148/149.0
VQYHYTAWPDHGVPTHAtSLLAFIRRIRNSvSRdAGPIVVHCSAGVGRTGTYIVLDAML
|.|.  . .|.  |...  . ||.| |... .|    .|..|.|| ||| |..|.  .|
vkYvRipitdeqapeee.dvDafvrliksl.pr.dtalvfnCqaGrgRTTtamviadLl
0048567 (Phosphotyrosine protein) phosphatases II 181-237 3.1e-06 21.6 In-house 40-101 (157) alignment 
Range on Protein: 181-237
Range on HMM: 40-101/157.0
YHYTAWPDHGvPTHATSLLAFIRRIRNS---VSRDAGPIVVHCSAGV---GRTGTYIVLDAML
.... . |.| | . . |  ||... .    ..   ..|.|||.||    |||.| | . ..|
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlil
PTPc_motif_SM00404 193-241 5.1e-06 21.4 In-house 64-109 (140) alignment 
Range on Protein: 193-241
Range on HMM: 64-109/140.0
THATSLLAFIRRIrnsvSRDAGPIVVHCSAGVGRTGTYIVLDAMLD-QMS
 .  ..|.||...     .. | ..||| ||| |..| |.   |   |.|
kyldkvldfiena....ekkggkvlVHCqaGvSRSatliiaYlmryrqls
subfamily_CDC14_pd Subfamily CDC14 202-252 3.4e-06 21.1 In-house 252-300 (328) alignment 
Range on Protein: 202-252
Range on HMM: 252-300/328.0
IRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMldQMSKEGAVDIFGFV
...  . . .  | |.||| ||.||||| |    |  .  .  | .. ...
vkkfleiaekaeGaiavhCkaGLGrtGtLiacylm..khyrftaaeaiawl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 206-278 1.8e-14 48.3 In-house 222-293 (297) alignment 
Range on Protein: 206-278
Range on HMM: 222-293/297.0
RNSVSRDAgPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|    |.| ...|||||||||.|  .  |..|... |.   |.  ..|. | || ..|||  |. ...|| ..
raemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 211-280 1.3e-14 48.6 In-house 245-315 (319) alignment 
Range on Protein: 211-280
Range on HMM: 245-315/319.0
RDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKE-GAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
 . ||.||||| ||||||. |  |  . .. .   .|||   ||. | .|   |.|  || ||.  | | |
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 216-283 1.5e-20 67.4 In-house 1-68 (69) alignment 
Range on Protein: 216-283
Range on HMM: 1-68/69.0
IVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCG
.|||||.| |||||.| .   . ..  |  ||||  | . |  | |||  | .||||||||.|| | |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 217-283 1.3e-19 64.3 In-house 1-67 (69) alignment 
Range on Protein: 217-283
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCG
|||||.| |||||.| .   . ..  |  ||||  | . |  | |||  | .|.||||||.|| | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 274-480 2.6e-13 44.2 In-house 33-236 (244) alignment 
Range on Protein: 274-480
Range on HMM: 33-236/244.0
DALMEAAKCGNTEFKVQDLhDRIKALQSRDPDSGETYIAKEFK--NLDIGDSDVETFDSASMPENKSKNRF-LVLPYDRTRVKLwpYPGVLGSDYINASF
.|.. |  . |   ..  . |  . . |     |  ||  ..   . .|   |   .  |  |.|  |||    ||.|  || |    | .|  ||||||
navlsanatknryinilpf.detrvilssskkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvpl..skgsmgntyinasf

IDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIkvrlKQTPDKGEFVVYGLlMVEVESEERQEG-YIK-RQLKISNTKSSEVRNVFH
.    .   .. || ||  |  |||.|. |     .|.|    |.     .  ||   .  |    . |   .|.|   ||  .|.|        . .  
vgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyee.ditvtltdrdefknikasnleiesdmneshqaltm

FQYEDWPEDGVP
||  .|| ||  
fqisnwpsdgtt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 283-576 5.9e-89 293.2 In-house 1-297 (298) alignment 
Range on Protein: 283-576
Range on HMM: 1-297/298.0
GNTEFKVQDLHDRIKALQSRDPDSGETYIAKEFKNLDIGDS--DVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREA
|||| ...||.  .. |.. ... . |  |.||..|. . |  . |. . |. ||||.|||.  ....| .|| |    .   ||||||||...|..|.|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPDKGEfVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDG
|.||||||..|..|||||..|... |.|||..  |  |.. ..  ||.|.   || . |.. |.|..  .|.|.||.|..|... |.| ....  ||. |
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

VPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYA
||.  . |.|.|... . |||.|| |..|.||.| ||.|||.||.  ||||| . ..|.||.|. ||..|| .||| |||.|.||.| .....|.|..
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0051299 (Phosphotyrosine protein) phosphatases II 283-569 1.1e-88 292.8 In-house 1-286 (288) alignment 
Range on Protein: 283-569
Range on HMM: 1-286/288.0
GNTEFKVQDLHDRIKALQsrdpDSGETYIAKEFKNLDIGDSDvETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFL
|.||..|..|......|.     .| |....||. |     |  |. .|..|||..|||.  .||||..|||| ...|| ||||||||.|| |..  .|.
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNT----KSSEVRNVFHFQYEDWPED
|||.||..|..|||||.||... ..|||.|  |. ..   |    |....|| ..|.  ||| ...|..|.|...|.    ...|.|.| ||.| .||..
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVPQDGKLVIDMLKHIARAQQqTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
|||.. .|..|.|... .|..  |.||. ||||.| ||||||.|. ..||...   ..|....|. ||.||| ||||||||.|.||.. ...
gvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 285-571 4.4e-73 240.9 In-house 2-299 (306) alignment 
Range on Protein: 285-571
Range on HMM: 2-299/306.0
TEFKVQDLHDRIKALQSRDPDSGETYIAKEFKNLDIG-DSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWpYPGVLGSDYINASFID--SYQQREAF
|..  .....|.. |.  . . . . . .||..|.    ... . . .. ||||.|||.  .||.| |||.|   |.| |||||||..|.  . ......
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksy

LATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVR-LKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKIS-NTKSSEVRNVFHFQYEDWPEDG
.|||  ||||..|||||.|. .|  .||. |. |  | .  .  ||. |   || . |.  ||.... || |.|..| ..|..| |.||......||. |
iatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhg

VPQDGKLVIDMLKHIARAQQQTG---NGPITVHCSDGSGRTGTFCAISIALERV---KLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEA
||.| . |.|.|... | |...    .||| ||||.| ||||||  | | |. .   .||| ||. ..|. .|.||  .||| .|||| |.......|.
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 297-578 6.2e-64 210.7 In-house 8-287 (287) alignment 
Range on Protein: 297-578
Range on HMM: 8-287/287.0
KALQSRDPDSGETYIAKEFKNLDIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWpypgVLGSDYINASFIDSYQQREAFLATQAPLETTINDFW
  .  .... |..   . |. |.  . . .    .  ..|| |||.  .|..|  || |         |||||.|||.|... ||.....|.  |. .||
gefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfW

RMLWEYESYTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTK-SSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIA
..... .  ..||| .. || .    |   ... ||.|   .|. .||...|||.|.|.. |.. ... ..|  .|. .|.. |  .. . .. ....  
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy

RAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYANF
..|.. ||..| |||||. ||...|||. ......| . .||.|| ... | |.| .||| ||||| ...| .....|. |..|
ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
0039614 (Phosphotyrosine protein) phosphatases II 299-570 5.9e-82 270.8 In-house 22-290 (297) alignment 
Range on Protein: 299-570
Range on HMM: 22-290/297.0
LQSRDPDSGETYIAKEFKNLDIGDSDvetFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGV-LGSDYINASFIDSYQQ-REAFLATQAPLETTINDFW
|. ... .. |.. .||..|     |   .  |  ||||.|||.  .||||..|||| |..|| |.|||||||..| | .   .|.|||.||. |..|||
llllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

RMLWEYESYTVVMLNKDSENIKVRLKQTPDKGEfvVYGLLMVEVESEERQEGYIKRQLKISNtkSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR
||.||. . ..|||.|  |. .   .  |..|.  .|| . |.. ..|  .||. |.|...|  ..|.| | |||| .||..|||.. .|....|. . .
rmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvre

AQQQT-GNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
|.... ..||. ||||.| ||||||.|. ..||...   ..|....|. || ||| .||||.||.|.|....... 
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_PTPN9_pd Subfamily PTPN9 299-569 4.8e-72 237.5 In-house 6-290 (297) alignment 
Range on Protein: 299-569
Range on HMM: 6-290/297.0
LQSRDPDSGETYIAKEFKNLDIgDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRM
| .   . |.  . ||....    . . ||. . .. | .|||.  || ||.|||.|   ..   ||||||.|.| |.|..||.||| ||. |..|||||
lvayvkekgkrGlskeyaeirn.epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrm

LWEYESYTVVMLNKDSENIKVRLKQTP--DKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR
.|| |  ..||  .  |. ... .|    ....   .| | |.. . | .| | .|.|.|.|.| .| |.| |||.  ||. |||.... ..|.|... .
vWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvre

AQQQ------------TGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
.| .            . . || |||| | ||||||... |.|.|..  .|.|...||. |||||  ..||||||.|||  |  . 
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0050432 (Phosphotyrosine protein) phosphatases II 300-575 1.5e-85 282.5 In-house 33-305 (308) alignment 
Range on Protein: 300-575
Range on HMM: 33-305/308.0
QSRDPDSGETYIAKEFKNLdIGDSDVETFDSASMPENKSKNR-FLVLPYDRTRVKLwpypGvLGSDYINASFIDSY--QQREAFLATQAPLETTINDFWR
.  ..  . ... .||. |     .......|..||||.|||   .||||..||||    .  ||||||||..| |   .. .|.|||.||..|..||||
kllekaldlglleeefeel.lsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MLWEYESYTVVMLNKDSENIKVRLKQ--TPDK-GEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHI
|.||... ..|||.|  || ..   |   ..  |....|| . |.. ||| ...|..|.|...|....|.| | ||.| .||..|||.. . ..|.|...
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

ARAQqqtGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDY
 . .   ..||| ||||.| ||||||.|. ..||... . ..|.|..|. ||.||| ||||||||.|.|... .... .  .
rksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 301-566 3.5e-69 228.5 In-house 26-288 (319) alignment 
Range on Protein: 301-566
Range on HMM: 26-288/319.0
SRDPDSGETYIAKEFKNLDIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLW
 .| |   | .  ||...     .  . . | ...|| |||.  .|..|...||| .  |. .||||||||.. ||... ..|.| ||. |..|||||.|
ksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiw

EYESYTVVMLNKDSENikvrlKQTPDKGEfVVYGLLMVEVESEERQEGYIKRQLKISN-TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR-AQ
||.. |.|.| ||        .  | |.. . ..   |.|.| |  . |. |....|. .|  ..|..  | .  ||. |||. .  .. ..|..    .
eyncstivlltkdkcs.....qywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts

QQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
.. .. .| |||| |.||||.. .. . |.|.| .  .|....||.|| ||. .||   ||||.|  . 
kenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
0047943 (Phosphotyrosine protein) phosphatases II 303-569 3.6e-81 267.9 In-house 6-272 (273) alignment 
Range on Protein: 303-569
Range on HMM: 6-272/273.0
DPDSGETYIAKEFKNLdIGDSDVETFDSASMPENKSKNRF-LVLPYDRTRVKLwpypGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEY
.. .| |....||. | .   .. |.  |..||||.|||.  .||||..||||    |  ||||||||..| |..  .|.|||.||. |..|||||.||.
ekllgltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

ESYTVVMLNKDSEN--IKVRLKQTPDKGE-FVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQ
 . ..|||... |.  .|      .. || ...|| . |.. |||  ..|..|.|...|....|.| | ||.| .||..|||.. . ........ .|..
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

QT-GNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
.. .|||. ||||.| ||||||.|. ..|....   ..|....|. ||.||| ||||||||.|.||.. ...
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 303-569 6.1e-79 261.2 In-house 21-304 (307) alignment 
Range on Protein: 303-569
Range on HMM: 21-304/307.0
DPDSGETYIAKEFKNLDIGDSD-VETFDSASMPENKSKNRF-LVLPYDRTRVKLWPYPGV-LGSDYINASFI--------DSYQQREAFLATQAPLETTI
.. .. | ..|||. |     . . ....|..||||.|||.  .||||.||||| ...|   .|||||||..        |.| .  .|.|||.||. |.
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

NDFWRMLWEYESYTVVMLNKDSEN-IKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNT-KSSEVRNVFHFQYEDWPEDGVPQDGKLVIDM
.||||||||. . ..|||... |.  .   .  ||.||...|| . |.. ||| ..||. |.|..... ...|.| | ||.| .||..|||.. . ..|.
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldf

LKHIARAQQQT-GNGPITVHCSDGSGRTGTFCAISIALERVKLDAT---IDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
.. . .|.... ..||. ||||.| ||||||.|. ..|.... . |   .|....|. || ||| .||.||||.|.||......
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0036941 (Phosphotyrosine protein) phosphatases II 304-570 5.1e-80 264.2 In-house 8-278 (297) alignment 
Range on Protein: 304-570
Range on HMM: 8-278/297.0
PDSGETYIAKEFKNLdIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLwpypGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYE
. .. ... |||. |        ... |. |||..|||.  .||||.|||||    .  ||||||||..| |..  .|.|||.||..|..|||||.||. 
kllflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

SYTVVMLNKDSENIKVR-LKQTPDK-GEFVVYGLLMVEVESEER--QEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQ
. ..|||... |. ..   .  |.. ||...|| ..|.. |.|    ..|. |.|....|...|.| | ||.| .||..|||.. . ..|... . ....
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

QT-GNGPITVHCSDGSGRTGTFCAISIALERVK---LDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
.. ..||. ||||.| ||.|||.|. ..|....      ..|....|. ||.||| .|||.|||.|.||.. ... 
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_PTPN23_pd Subfamily PTPN23 305-570 9.9e-59 193.5 In-house 11-281 (288) alignment 
Range on Protein: 305-570
Range on HMM: 11-281/288.0
DSGETYIAKEFKNLDIGD-SDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWpypgVLGSDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEY
 .|.| . |.||.|.  .  . . .  |    . .|||.  .||||..||||         |||||||. .       |.||||||..|.||||.|..| 
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

ESYTVVMLNKDSENIKVRLKQ--TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR---A
 | ..||| . .|  | . ..    |||| |..| | | ..|... | ...|.||..  ....|..| | |.. ||| |||.  . ....|. .     |
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayea

QQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDAT-IDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
.|.  . |. |||| |.||||.|. .  |.. .. .   .|. | |. ||.||  |||. ||.||.||.| . ..
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 305-572 1.4e-31 104.6 In-house 12-281 (307) alignment 
Range on Protein: 305-572
Range on HMM: 12-281/307.0
DSGETYIAKEFKNLDigDSDVETFDSASMPENKSKNRFLVLP-YDRTRVKLwPYPGvLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYES
| | . .  ||..|   . . |.    ..  |  |||.  ..  |..|. .  ..| | |||| | ..    .   |...| |||.|. .|| |  . . 
dkgvqalvdefrvla..kktpegvtveafsantdknryqdvkcqdkgrivv.kfdg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekv

YTVVMLNKDSENIKVRLKQT--PDKGEFVVYGLLMVEVESE-------ERQEGYIK-RQLKISntKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHI
 .|.|| |  |  |.. .|    ..|.  |.|     .  .         .| .|.  .||.    ... | . |.|.|.||. ||||     |..|. .
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvd..waqksrtiqhlqwenwpdrgvpqinltainlleav

ARAQQqtgngPITVHCSDGSGRTGTFCAISIALERV-KLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV-RHFVEAF
   .      |. |||| | ||.||  |||.  ... .     || . |..||.||.  .||  || . . |.  .|.| .
rydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflely
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 306-569 1.1e-72 239.5 In-house 18-279 (288) alignment 
Range on Protein: 306-569
Range on HMM: 18-279/288.0
SGETYIAKEFKNLDIGDSDVETfDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESY
...| . .|...|   ... .. . .. ..|..|||.  .|||| .||||   . . |.||||||.||.........|||.||  |.||||.. .|... 
rnrtgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

TVVMLNKDSENIKVRLKQ-TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISntKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTgNG
|.|||..  |. | . ..  ||... . || . |.. ... .| ...|.| .   |. . ... ..||  ||..|||.. . ....|. .  |.|.   |
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tg

PITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
||.||||.| |||||| |.  ....|. . .||.. || .|| ||. .||| .|| |.|||. . .
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 307-573 2.1e-132 436.0 In-house 21-287 (319) alignment 
Range on Protein: 307-573
Range on HMM: 21-287/319.0
GETYIAKEFKNLDIGDSDveTFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYT
|||...||||.|.....|  ||||||..|||.|||.  .|.||||||.|....|| |||||||||||.||.||.|.|||||||.||.|||||.||.||..
getllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessi

VVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKIsNTKSSEV--RNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNG
||||.|..|..||.||..... .|..|| |.|..|.||..|.||.|.||. |.|||||  |.|.||||..||...||.......|.||.|......| .|
vvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

PITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFS
||.||||.|.||||||......|||||.....|.|.||..|||||.||||.||||||.||.....|||..
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 307-577 1.8e-93 308.1 In-house 18-288 (318) alignment 
Range on Protein: 307-577
Range on HMM: 18-288/318.0
GETYIAKEFKNLDIGDSDVETFDSaSMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYT
||... .|...|.  .. | ...|   | || |||.  .|.||.||||| .  |. |||||||..|| |....|..|.||||  ||.|||||.|| .| .
Gelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

VVMLNKDSENIKVRLKQT-PDKGEfVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGP
.||| . .|. |.....  |.||    || |.||...| . . |. |..|...|...|.|.|  ..| .||. |||..|  ..|..... .|||..|.||
ivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

ITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYAN
|.|||| | ||||.|.|..| |||.| .|..|.||||..||.||..|||| .||.|.|.|.  .....  ...
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_PTPRB_pd Subfamily PTPRB 307-570 1.9e-70 232.2 In-house 23-286 (293) alignment 
Range on Protein: 307-570
Range on HMM: 23-286/293.0
GETYIAKEFKNLDIGDSDVeTFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYT
 .. ...|...|   ..|  . ..|. ..|..|||.  .|||| .|||| .  .  |||||||..|. |...  |.||| || .|..|||||.|| .| .
sdlrfseeyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

VVMLNKDSENIKVRLKQ-TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNtkSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQ-QQTGNG
.||| .  |. ||. ..  |.. | |.|| . |.. .||..| .. |.|||..  ..| |.| ....  ||. |||.. | ..|..... .|. ... ..
ivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

PITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
||.|||| | |||||| |.   |.... . ..|.| .| .||..| ..||| .|| | ...| ....
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPRG_pd Subfamily PTPRG 307-570 1.3e-69 229.9 In-house 17-288 (563) alignment 
Range on Protein: 307-570
Range on HMM: 17-288/563.0
GETYIAKEFKNLDIGDSDV-ETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGS-DYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYES
|.. ...||..|     .   . .... |||| ||| | ...|||.|||| | ||. .. |||||..|| ||. .||.||| ||..|..|||||.|| ..
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

YTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTK-----S-SEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQ
 ..||. .  |. .   ..   | | . || | |  ..||.   | .|.|.| |.|     .  ....| ...| .||. |||.    |. . |. ..|.
aiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

QQTgNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
...  |||.|||| | |||||.....  |.... . ....|.... .|.||. .||| ||| | ....   . 
kae.aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 307-575 9.1e-66 216.7 In-house 18-289 (290) alignment 
Range on Protein: 307-575
Range on HMM: 18-289/290.0
GETYIAKEFKNLDIGDSDVETfDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVL--GSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYES
|..   ..|| || |.|. ..   .  ..|| .|||  ...||  |. | | .|      .||||..|. |.......|||.|.. |. |||...|. ..
gnegfrnqfkmldsgesehtv.tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekv

YTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKS-SEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGN
  .||| .  |. ||. .|   . .   ||   ... .||  ..||.|.|.. |..|  . ..| ..|   |...|  .. . .. ..... . | ..||
tiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgn

GPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDY
..| |||||. ||...|||. ......| .  ||.|| ....|.|.| .||| .||.. ...| . .. |. |
tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
0040438 (Phosphotyrosine protein) phosphatases II 308-569 7.5e-85 280.3 In-house 17-276 (317) alignment 
Range on Protein: 308-569
Range on HMM: 17-276/317.0
ETYIAKEFKNLDIGDSDveTFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTV
 |.. .||..|.  . |  |.. |..||||.|||.  .||||..|||| |..|.|.|||||||..| .... .|.|||.||. |..|||||.||. . ..
ftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

VMLNKDSEN-IKVRLKQTPDkGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqTGNGPI
|||..  |.  .   .  |. ||...|| ..|.. |||  .|.. |.|.......||.| | ||.| .||..|||.. .|..|.|. . .|..  ..||.
vmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpv

TVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
 ||||.| ||||||.|. ..||...   ..|....|. || ||| .|||||||.|.|.......
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0043336 (Phosphotyrosine protein) phosphatases II 308-568 4e-81 267.8 In-house 19-276 (278) alignment 
Range on Protein: 308-568
Range on HMM: 19-276/278.0
ETYIAKEFKNLDIGDSdvETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTV
 | . .||..|.  .   .|.. |  ||||.|||.  .||||..||||....|.|.|||||||..| |.. ..|.|||.||. |..|||||.||. . |.
ktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VMLNKDSENIKVRLKQTPDkGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqTGNGPIT
|||... |. .|   |    |....|| . |.. .|| ...|. |.|...|....|.| | |..| .||..||| . .|..|.|| . .|.. . |||. 
vmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvl

VHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
||||.| ||||||.|. ..||...   ..|....|. ||.||| .||||.||.|.||.....
VHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Ptp69D_pd Subfamily Ptp69D 308-568 7.1e-73 240.4 In-house 21-285 (307) alignment 
Range on Protein: 308-568
Range on HMM: 21-285/307.0
ETYIAKEFKNLDIGDSDVETFDsASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTV
.  .|||...|    .| .|   .   ||. |||.  . ..|.||||| . .|   ||||||||| .|.... |.| |.|.|.||.|||||..| |....
dfglakeyekLeareidkstkv.sekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLNKDSENIKVRL-KQTPDKgEFVVYGLLMVEVESEERQEGYIKRQLKISNTK-----SSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQT
||| . .|  . .  |  |.  . | || ..|.. |||... ||.|.|..|..|       . |.|  ..|  |..  ||.  . ........   ... 
vmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln

gNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
 ..||.|||| |.||.|.| |... |...|.. ..|.|.||..|| ||...||  |||.|.|  .  .
.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 308-569 8.6e-46 151.1 In-house 5-259 (267) alignment 
Range on Protein: 308-569
Range on HMM: 5-259/267.0
ETYIAKEFKNLDIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYpgvlGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTV
|. | |||....   ..  |       .|. .||.  .|||| ||| |         .|||||....|....||..|| ||. || ||. .. ...  ..
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk....eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLNKDSENiKVRLKQTPDKGEFVVYGLLMVEVESEERQEGY--IKRQLKISNtksSEVRNVFHFQYEDWPEDGvpQDGKLVIDMLKHIARAQQQTGNGP
|.| |  .. ..||   |  |.   |  | ||   |. .. |  |  .||. |      .||  . |. |  .   ..   .  ..  .|. | . || |
vlltkvftd.nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn...esahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrP

ITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
. |.|||| ||.|||  |   |||.| . . |.|. .|..| ||. .|.| |.| ...|.. .. 
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 308-569 8.3e-21 68.7 In-house 25-285 (302) alignment 
Range on Protein: 308-569
Range on HMM: 25-285/302.0
ETYIAKEFKNLDIGDSDVETfdSASMPENKSKNRFLVLP-YDRTRVKLWPYPgvlgSDYINASFIDSYQQREAFLATQAPLETTI---NDFWRMLWEYES
.. . ||||..|    |.|     .  .| .||.   .| .| ..|||   |     .|.||| ..  . ..  . .| |  ..    ..|||| .. . 
taevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

YTVVMLNKDSENIKvRLKQ-TP-DKGEFVVYGLLMVEVESEERQEGYI-KRQLKI--SNTKSSEVRNVFHFQYedWPEDGVPQDGKLVIDMLKHIaRAQQ
 .||.| .. |  |  |..  |   |... || ..| .   |..|.   .  . .   .   | . || ....  |... ||.    .|   ...  |..
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakv.fakk

QTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
. .. .. .    |.|| |.| .  .|.|... ..   . ..|...|.||| .|.. .|| . | ..  ..
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_PTPRN_pd Subfamily PTPRN 309-571 1.3e-51 170.1 In-house 29-294 (297) alignment 
Range on Protein: 309-571
Range on HMM: 29-294/297.0
TYIAKEFKNLDIGDSDVETFDSASMPENKSKNR-FLVLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQR-EAFLATQAPLETTINDFWRMLWEYESYTV
. ..||.. |   ... .| . |. ..| .|||   ||||| .||||        |||||||.|   . |  |..|||.|| .|. |||.|.||  .  .
drlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

VMLNKDSE-NIKVRLKQTPDKGEfVVYGLLMVEVESEE-RQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQtGNGP
|.| . .| ..|   .  ||.|.  ||..  |.. ||    . |. | . . | ..|| | |  | .  ||| |||   | .... . . .. .     |
vnltrleeegvkqckrywpdeGs.evyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscp

ITVHCSDGSGRTGTFCAISIALERVKLDA-TIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEA
| ||||||.||||....| . |.|..  .  ||.  |.  || ||| .|.| .|..|.. .| . |.|
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevna
DSPc_SM00195 311-569 1.1e-78 259.5 In-house 2-262 (263) alignment 
Range on Protein: 311-569
Range on HMM: 2-262/263.0
IAKEFKNLDIGDSDVeTFDSASMPENKSKNRF-LVLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVML
. .||..|.  .|.  ....|  ..||||||.  .||||.||||| . ..  |||||||..|. ....... |||.||..|..||||| || .. ..|||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NKDSENIKVRLKQ-TPDK-GEFVVYGLLMVEVESEERQE-GYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTgNGPIT
....|| | . ..  |.. |.  ..| . |.. ..| ..  .|.|.|...... .| |.| ..||..||. |||.. | |...|. .   .... .||| 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
||||.| ||||||..|.|.|.... . ..|.|..|..||.||| |||| |||.|.||.. ...
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 311-569 1.1e-78 259.5 In-house 2-262 (263) alignment 
Range on Protein: 311-569
Range on HMM: 2-262/263.0
IAKEFKNLDIGDSDVeTFDSASMPENKSKNRF-LVLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVML
. .||..|.  .|.  ....|  ..||||||.  .||||.||||| . ..  |||||||..|. ....... |||.||..|..||||| || .. ..|||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NKDSENIKVRLKQ-TPDK-GEFVVYGLLMVEVESEERQE-GYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTgNGPIT
....|| | . ..  |.. |.  ..| . |.. ..| ..  .|.|.|...... .| |.| ..||..||. |||.. | |...|. .   .... .||| 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
||||.| ||||||..|.|.|.... . ..|.|..|..||.||| |||| |||.|.||.. ...
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 311-569 3e-65 215.1 In-house 17-276 (281) alignment 
Range on Protein: 311-569
Range on HMM: 17-276/281.0
IAKEFKNLDigDSDVETFDSASM-PENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVM
 ..|...|   . .|.   .||  .||. |||.  .  || ||||. |      .|||||.|...|.. ....|||.|. .....||.|.||..  ..||
fieeyekla..aigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivm

LNKDSENIKVRLKQ-TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKIsNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITV
. .. |. |..  .  ||. . . || ..|. ..||... ||.|..|. ...|.| |.| ...|  ||. |||.. | ...  | . .....  . |. .
vtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSDGSGRTGTFCAISIALERVKLD-ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
||| | |||||. |.  ....|. . ...|. ..|..|| .| .||||  ||.| | .| . .
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 311-577 6.1e-58 190.9 In-house 17-301 (301) alignment 
Range on Protein: 311-577
Range on HMM: 17-301/301.0
IAKEFKNLDIGDSDVETFDSASmpENKSKNRFL-VLPYDRTRVKLWPYP--GVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVV
.....|.|. |...  |    .  |||  |||  . .||  |. | | |   .   .|||||.||.|.....| |.|.|.. |. ||||..|..   ..|
feeqykelkegedksctvglse..enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQ-------------------EGYIKRQLKISNTKssEVRNVFHFQYEDWPEDGVPQDGKLVID
|. .  |..| . .|   ..|   .    ..|.  . |                   .|||.|..|....|  . ..|  .|  |||.||| .. . |. 
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLq

MLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYAN
 .  .  .||. | ||. |||||. .|.|..|..||.|| .| .  .|.|| .. .| ..| .|.| ||| . |.|.  ...  | |||
viddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 311-568 8e-50 164.2 In-house 12-276 (287) alignment 
Range on Protein: 311-568
Range on HMM: 12-276/287.0
IAKEFKNLDI-GDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWpYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVM
. ||...|    .|   || .|    . .|||.  |||.| ||| |    | |||||||| .. ||.. |||.|.|.|. .|..||||...| .| .|..
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LNKDSENIKVR-LKQTPDKGE-FVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQD----GKLVIDMLKHIARAQQQTGN
. .. |. . .  |  |..     | |  .| .. . ..  |  | |.. . .. | | |  ... .||.....       ..|.|. .||  |.. .. 
mtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasev

GPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
||. ||.. | ||.|.. |. . ..| .    .|. ..|  || .|  .||.. |... || .  .
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_ptpA1_pd Subfamily ptpA1 311-529 2.7e-35 116.9 In-house 23-256 (418) alignment 
Range on Protein: 311-529
Range on HMM: 23-256/418.0
IAKEFKNLDIGDSDVETFDSAsMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQReAFLATQAPLETTINDFWRMLWEYESYTVVML
| .||. |.      || .      | ||||.  .|| ..|||.|       ||||||| .||    .  |..|| ||  || |||||.||     .|||
ikeefrlleesvgpsetsegd.kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivml

NKDSENIKVRLKQ-TPDK--G-EFVVYG----------LLMVEVESEERQEgYIKRQLKIsnTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR
...||| ...  .  |..  | .| .||          . .|||  .  .|  | |....  |   | |.. ..||| ||.  .|.  . . ..|. |. 
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpere.iitrnirl..tfegetrditqyqyegwpdhnipdhtqpfrqllhsitn

AQQQT-----GNGPITVHCSDGSGRTGTFCAISIALERV
 |.|       | || |||| | |||||||.  | ....
rqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 311-570 6.1e-27 89.0 In-house 29-291 (310) alignment 
Range on Protein: 311-570
Range on HMM: 29-291/310.0
IAKEFKNLDIGDSDVETFDSasMPENKSKNRFL-VLPYDRTRVKLWPYPgVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVML
..|....||  .    |...  . ..  |||.  |.  | .||||         ||| | .. .   |..|. .| ||. || |||||...  . ....|
lvkqyrkldakqdssltyea..ykkymhknrysdvvcldtsrvklkidk.sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll

NKDSENIKVR-LKQTPDKGEFVVYGLLMVEVESEERQEGYIK--------RQLKISNTKS-SEVRNVFHFQYEDWPEDGVPQDGKLVIDmlkhiARAQQQ
 | .|. . . .   |  |    || . |   ||  .|  |          .. . .  .  .   |   .. .||. |||..    .       |   |
ckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.....qrllaq

TGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
   ||  |||| | .|... .|. .......    .|. . . .|. .| | .||. || .   |   |. 
vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar
subfamily_CG42327_pd Subfamily CG42327 311-493 5.7e-24 79.4 In-house 7-190 (319) alignment 
Range on Protein: 311-493
Range on HMM: 7-190/319.0
IAKEFKNLD--IGDSDvetfdsASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQR-EAFLATQAPLETTINDFWRMLWEYESYTV
.|.||..|   |  .|      .  .  | |.|.. |.|   ||| |   .    . |..||..  |..    ..|.|..|| .  ||||..||  | ..
vaeefrdlPqliarad......evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvi

VMLNKDSENI-KVRLKQTPDKG---EFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYeDWPEDGVPQDGKLVIDMLKHI
| | . ||.  ||  .  | |    .  .|| ..| .   | .. |.   | . . . .| |.. |. | .|.| .|| . . .| || ..
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 311-384 6.2e-10 33.1 In-house 25-94 (95) alignment 
Range on Protein: 311-384
Range on HMM: 25-94/95.0
IAKEFKNLDIGDSDVETfdSASMPENKSKNRFL-VLPYDRTRVKLWpypGVLGSDYINASFIDSYQQREAFLATQ
. .||| . .      |    |   |  ||||| ..||| ||| |        |||||| |.| | ......|.|
fdnefksismtsgapyt..vgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaq
0046845 (Phosphotyrosine protein) phosphatases II 312-576 1.8e-82 272.2 In-house 3-281 (284) alignment 
Range on Protein: 312-576
Range on HMM: 3-281/284.0
AKEFKNLDIGDSDVE-TFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGV-LGSDYINASFIDSY-----QQREAFLATQAPLETTINDFWRMLWEYES
 .||. |     ... ... | .|||.||||.  .||||..|||| ...|   .|||||||..| |      .. .|.|||.||..|..|||||.||...
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

YTVVMLNKDSENIKVRLK-QTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTK-SSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQ-T
 ..|||..  || ..      |..||...|| ..|.. ||| ...|..| |...|.. ..|.| | ||.| .||..|||.. . ....|. . .....  
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GNGPITVHCSDGSGRTGTFCAISIALERVKLDA---TIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYA
|.||| ||||.| ||||||.|. ..||... .    ..|....|. ||.||| ||||.|||.|.||.. ...  .  ..
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
subfamily_PTPRA_pd Subfamily PTPRA 312-568 3.4e-80 264.4 In-house 35-294 (330) alignment 
Range on Protein: 312-568
Range on HMM: 35-294/330.0
AKEFKNLDIGDSDvETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLN
 .||..|  |. .  |.. ||  ||| |||.. .|||| .|| | .  ||  |||||||||| |.... |.|.| |.| |..|||||.||..| |.||| 
reefnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

KDSENIKVRLKQT-PDKGeFVVYGLLMVEVESEERQEGYIKRQLKIS----NTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNgPI
.  |  . . .|  ||.|  | || . |||| |.  . |  |.. .     .|.  ..| |  | .. ||. ||| ... ....||.. . .||... ||
elkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pi

TVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
.|||| | ||||||....  ||||| .  .|.|..|..||.||| |||| |||.|.|.|....
vvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPN13_pd Subfamily PTPN13 312-566 2.1e-58 192.8 In-house 14-266 (273) alignment 
Range on Protein: 312-566
Range on HMM: 14-266/273.0
AKEFKNLDIGDsDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGvlgsdYINASFIDSYQQRE--AFLATQAPLETTINDFWRMLWEYESYTVVM
|.|||.|      ..| ...   |||.|||.  |||||.|||||    |     |||||.|    . .   ..|.| || .|..|||.|.|| ..  ..|
aeefkelrelk.pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LNKDSENIKVRLKQ-TPD--KGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqtGNGPI
. .. |. ||. ..  |.  . . .|.. | ||..  ....|.  |.|......|.|.|.| |... .||. |||.  . .. ......| |.   .|||
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPi

TVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
 |||| | ||.||. .| ..|. .. |  .|. ..||.|| ||  .||| .|| |.|... 
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail
subfamily_PTPN14_pd Subfamily PTPN14 312-570 1.7e-54 179.9 In-house 26-297 (300) alignment 
Range on Protein: 312-570
Range on HMM: 26-297/300.0
AKEFKNLDIGDSDvETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVlGSDYINASFIDSY--QQREAFLATQAPLETTINDFWRMLWEYESYTVVM
 .|. ..     |  ....|..|||..||||  ||||. .||.| |      ..||||| |      ..  ....|.|||.|..|||.|.|| . . .||
fteyeripkkred.allstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LNKDSENIKVRL-KQTPDK---GEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIA---RAQQQT-
| .. |. | .  |  |..    . | .|   |  .  |  . .| ..||.    |.| |.|.|.|| |||..|||.| |  .. |...    |. ... 
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

----GNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
     . |. ||||.| ||||      . .. .. . .||. .... ||.|| ..|||  |||| |.|. ....
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 312-565 4e-54 178.4 In-house 12-262 (283) alignment 
Range on Protein: 312-565
Range on HMM: 12-262/283.0
AKEFKNLDIGDSDVetfDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGvlgsDYINASFID---SYQQREAFLATQAPLETTINDFWRMLWEYESYTVV
 . .|.| . | |.   | ||  ||| |||.  ..|.|. ||.| . .     |||||.||    ||.| . ....|.||. |. |||.|... .  ..|
revlkrlsvpdlda...diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLNKDSENIKVRLKQT-PDKGeFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSE--VRnVFHFQYEDWpedgVPQDGKLVIDML---KHIARAQQQTG
|| |  |. ...  |  | .|  . || . | .. |  .. .|...| . .  |..  .  . |.|..||    .  . . .|. |     .   |..  
mltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidW....leygeqaiinslvkfnkvislqtesk

NGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
.||| |||| | |||..|.|.| ... .. .. .|.|..|...| ||. .||| .|||. .|.|
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 312-573 4.9e-31 102.4 In-house 14-273 (281) alignment 
Range on Protein: 312-573
Range on HMM: 14-273/281.0
AKEFKNLDiGDSDVETFDSASMPENKSKNRFLVLP-YDRTRVKLWP-YPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVML
 .|| ||  ||   .       | |. |||.| .|  | .||.|    |    .||| | .| |   .  .. || | . |  |||||.|. .. ..|||
kqefsnlp.gdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

NKDSENIKVRLKQTPDKGEFV--VYGLLMVEVESEERQEGYIKRQLKISNtkSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIaRAQqqtgNGPITV
 .  |  . .  .   .   .   .  | |. |    ..  .  .|..|     | | . |. ...||.  ||.  .... .|..| ||.      |  .
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrki.rar....stppvi

HCSDGSGRTGTFCAISIALERVKLDATI-DMFQTVRNLR-TQRPIMVQTPEQYKFCYEVVRHFVEAFS
||| | ||.||. |. |||. ..   |. |. | |  || | |   ||| .|| . ..|.  |  |. 
hcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 313-572 1.6e-75 249.1 In-house 26-286 (305) alignment 
Range on Protein: 313-572
Range on HMM: 26-286/305.0
KEFKNLDIGdsdVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLN-
...|.|       |..|  .  .||.|||.  . ..|  |..| . . .  |||||||..|.|.........|.||..|..||||...|.   |.|||  
aqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk

-KDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISN-TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITVH
 .. .. | |   .  |.| . .| ..||..||.  ..||.|.||||.  ...| |.| ..|  |||..||||    .....|.. ..|..  . |..||
lveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVh

CSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAF
||.| ||||.|.|..|||||.| . ..|.|. ...||..|. |||| .|| |.....   ....
CsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 319-568 3.2e-64 211.7 In-house 27-276 (315) alignment 
Range on Protein: 319-568
Range on HMM: 27-276/315.0
DIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIK
|. | |.    .|  ..| .|||.  .||.|..||||        |||||||.| |... .|..|.|.||.....|||||.....  |.||..| .|. |
dlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdk

VRLKQT-PD-KGEFVVYGLLMVEVESEERQEGYIKRQLkiSNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIaRAQQQTGNGPITVHCSDGSGR
.. .|  || |.. | .| . ||. | | . . ..|.|     || | |.|  ||...||. ||...   .. ..| . .|.... . .. |||| | ||
ikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikev.kadngkkefsllvhcsaGvGr

TGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
|| ...|   ....|   ..|.|..|.|||..|| .||| |.| | |..|.  
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 319-565 1.2e-45 150.5 In-house 28-232 (392) alignment 
Range on Protein: 319-565
Range on HMM: 28-232/392.0
DIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIk
|. . |.    .|  . |. |||.  .||||..||||     .  |||.|||.|.|... .|..|.|.|  ....|||||... .  |..|..|  |   
dlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.

vrlkqtpdkgefvvygllmveveseerqegyikrqlkisntKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIaRAQQQTGNGPITVHCSDGSGRTG
                                         |  ..| |  |.. .||...||.    .. ..| . .|.      |. .||| | ||||
.........................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtg

TFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
   .|   . . |    .|.|. | |.| .|| |||| ||| | |  |
vvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 321-566 2.4e-67 222.4 In-house 10-252 (284) alignment 
Range on Protein: 321-566
Range on HMM: 10-252/284.0
GDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENikvr
   .  .   | ...|| |||.  .|..|...||| .  |. .|||||||||  ||... ..||| ||. |..|||||.|||.. |.|.| ||       
lgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltkdkcs....

lKQTPDKGEfVVYGLLMVEVESEERQEGYIKRQLKISN-TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR-AQQQTGNGPITVHCSDGSGRTG
 .  | |.. . ..   |.|.| |  | |. |....|. .|  ..|..  | .  ||. |||. .  .. ..|..    ... .. .| |||| |.||||
.qywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtg

TFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
.. .. . |.|.| .  .|....||.|| ||. .||   ||||.|  . 
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 322-484 1.9e-20 67.9 In-house 19-184 (297) alignment 
Range on Protein: 322-484
Range on HMM: 19-184/297.0
DSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPypGVLGSDYINASFIDSYQQRE--AFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKV
..  |.| ||  .    |||.  .| .| |||||    .. ..||||| ..   .. .   .. .| ||..|..|||....| .  ..||. |  |. . 
eargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

RLKQ-TP-DKGEFVVYGLLMVEVESEERQEgYIKRQL-KISNTKSSEVRNVFHFQYEDWPEDGVPQDGK
.     |  ..|    | ..||  |.  .| . . .| ..     || | | | |.  ||. ||| | .
kcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 323-569 2e-60 199.4 In-house 36-280 (315) alignment 
Range on Protein: 323-569
Range on HMM: 36-280/315.0
SDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLK
 ..  .| |   ||| |||.  ...||..||.|       .|||.||.||| |.... ..|.|.|. ....||||...|..  ..|||..  |. | . .
gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkae

-QTPDKgeFVVYGLLMVEVESEERQEGYIKRQLkiSNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGnGPITVHCSDGSGRTGTFC
   |||   |.|| . |   ||| .. |  | |  | .  ...|.|. ..|  ||. |||.    .... ... . ....  |.| ||||.| ||||||.
kywpdk..kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfi

AISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV-RHFV
...  |.... .  ||... ....| .|  |||. |||.| |...   ||
tldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_egg_pd Subfamily egg 323-570 2.5e-24 80.5 In-house 27-271 (307) alignment 
Range on Protein: 323-570
Range on HMM: 27-271/307.0
SDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLN--KDSENIKVR
.| ...  |   .|. | |   |   | .||||    |    |.| |  ..     . |. .||||  | .|||||... |   .|||.  |.||. .  
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyy

LKQTPDKGEFVVYGLLMVEVES-EERQEG-YIKRQLKISNTKsSEVRNVFHFQYeDWPEDGvpqDGKLVIDMLkhiaRAQQQTgNGPITVHCSDGSGRTG
  .....   .| | | .|    ... .  .   .||.  ..  | | . |.|. |. . .   |    . .|    |  ..    |. |.. .|  ...
wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwqg.dvnnss...dvysplrvl....rklrnl.skpvvvqdilGvskaa

TFCAISIALERVKLDATI--DMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
|. || |||  .    .    . ..|  || .|.. |... .| | | .|  |. 
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
0045098 (Phosphotyrosine protein) phosphatases II 324-570 3.8e-73 241.6 In-house 21-273 (278) alignment 
Range on Protein: 324-570
Range on HMM: 21-273/278.0
DVETFDSASMPENKSKNRFL-VLPYDRTRVKlwpypgvlgsDYINASFIDSYqqREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ
.. ..  | ...|..|||.  .||||..|||          ||||||.||.|  . .|.|||.||..|..||||||||. . ..|||..  |. ..   |
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNT----KSSEVRNVFHFQYEDWPEDGVPQDG--KLVIDMLKHIARAQQ------------QTGNGP
    |....|| . |...|||. . |..| |.. |.    .. | |.|.|..|  ||. ||| .   | ....|. | .|..            . ..||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ITVHCSDGSGRTGTFCAISIALERVklDATIDMFQTVRNLRTQRPI-MVQTPEQYKFCYEVVRHFVE
. |||| | |||||..|. . ||..  . ..|....|. ||.|||. .||..|||.|.||.......
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPRK_pd Subfamily PTPRK 324-565 5e-71 234.1 In-house 31-273 (314) alignment 
Range on Protein: 324-565
Range on HMM: 31-273/314.0
DVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRL-K
 .| .|.|   ||..|||.  .|.|||.||.| .  |   ||||||..||||.. .||..|| ||. |..||||....... ..|||..  |. .|.  |
lfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClk

QTPDKGEFvvYGLLMVEVESEERQEGYIKRQLKISN--TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQtGNGPITVHCSDGSGRTGTF
  |...|   || . ||. . | .. ...| .....   . .|.| | .||.  ||. .||.  . ........   |.. ..|.| |||| |.||||||
yWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtf

CAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
.||.| |. .. . ..|.|..|..||.... ||.| |||||.|.|.
iaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 324-566 2.6e-58 192.7 In-house 36-285 (325) alignment 
Range on Protein: 324-566
Range on HMM: 36-285/325.0
DVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ
|  ..  |  ||||.||||  |...|..|| |        |||||||.. ...... |||.|||| .||||.||.. ....  ||.||.  .. .   . 
dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavy

TPDK-GEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQ-----QTGNGPITVHCSDGSGRT
 |.. |. . .| | |.. . |    |..|.|.. ..|  | | |  ||.  |.. ||..    .| .|. .   ..       . .|| ||||.| |||
wpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrt

GTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
|.| ..  ||..|  .. .|.|. |..|| .|| ||.| .|| ..|| . 
Gvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 324-570 8.1e-27 88.7 In-house 36-288 (305) alignment 
Range on Protein: 324-570
Range on HMM: 36-288/305.0
DVETFDSASMPENKSKNRFL-VLPYDRTRVKLwpyPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENI-KVRLK
|.| . .    ... |||.  |   |. ||||    |    .|| | .. .  . . |. |||||| |  ||| | ..    .. || .  |   |  |.
dfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcle

QTP-DKGE---FVVYG-LLMVEVESEERQE------GYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHiARaqqqTGNGPITVHCS
  . ....   |   |  ..| .|| .. .        ...   . .   ...| | |. . |||. |||     ....|.. ||    .  |||.||||
yfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek.ar....pskgpivvhcs

DGSGRTGTFCAISIALERVKLDATIDMFQ-TVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
 | ||||.   .   |...     |.  .  .. .| ||   .|| .|| | ..|.  ...
agigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_PTPRD_pd Subfamily PTPRD 325-575 4e-105 347.6 In-house 37-287 (564) alignment 
Range on Protein: 325-575
Range on HMM: 37-287/564.0
VETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQT
 .|...|..|.||.|||.  ...||..||.| ...|. |||||||||||.|..|.|..|||.||..||.|||||.||..| |.|||.| .|. ||.... 
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

-PDKGeFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQqQTGNGPITVHCSDGSGRTGTFCAI
 |.||    || |.|..|.||. . |. |..|....||||.|.| .|.. .||. |||. .. ..|..... ... ....|||.|||| | ||||||..|
WPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivi

SIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDY
.. |||.| ..|.|..|.|..||.||..||||.||| |..|.. ........ 
damlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 325-574 1.6e-27 91.0 In-house 43-295 (305) alignment 
Range on Protein: 325-574
Range on HMM: 43-295/305.0
VETFDSASMP-ENKSKNRFLVLPYD-RTRVKLwPYPGvlGSDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLK
  .|..   .  ...|||.  .| . .. |||   |    |||| | ..         |...| ||. ||..|| |. .     .||| |  |  |..  
qvafnanqsadiaitknryqdvpcqdqsavkl.dkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

QTP--DKGEF--VVYGLLMVEVESEERQEGYIKRQLKISNTKS--SEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIaRaqqqTGNGPITVHCSDGSGR
|     .||   .  |... .|      |   . |. . |     ..   | |.|. .||. |||      ...|  | |      . || |||| | ||
qywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai.r....gskvpivvhcsagigr

TGTFCAISIALERVKLDA-TIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV-RHFVEAFSD
|||  ||   ||..  .     | . |. || ||   .|.  || | . |.  .|.| . .
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke
subfamily_PTPN3_pd Subfamily PTPN3 327-566 3.8e-59 194.9 In-house 32-272 (280) alignment 
Range on Protein: 327-566
Range on HMM: 32-272/280.0
TFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGvlgsDYINASFID----SYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLK
. . | .||| ||||.  .|||| |||||   .     |||||....    | ..   ..||| ||..| .|||.|.|| .| ..|||    |. .|. .
aisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

Q-TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAqQQTGNGPITVHCSDGSGRTGTFC
|  |.... . || ..|..|.|.... |. |.| .......| |.....|| .||. |||.| . ........ .. ... . |. |||| | |||| . 
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl.rsgkeePvvvhCsaGigrtGvli

AISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
.. .||  .     . . . ||..| || ..|||..||||  | . 
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
0040439 (Phosphotyrosine protein) phosphatases II 328-568 3.7e-77 254.6 In-house 3-245 (249) alignment 
Range on Protein: 328-568
Range on HMM: 3-245/249.0
FDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDK
.. |..||||.|||.  .||||..|||| ..||. .|||||||.|| |..  .|.|||.||. |..||||||||. . ..|||... |. ..   |  . 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

GEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQT-GNGPITVHCSDGSGRTGTFCAISIA
|....|| ..|.. |.|  ..|. |.|...|.. .|.| | |.|| |||..|||.. . ..|... .  |....  .||. ||||.| ||||||.|. ..
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

LERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
||...   ..|....|. ||.||| .||.||||.|.||.....
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPN12_pd Subfamily PTPN12 328-570 1.9e-67 222.2 In-house 32-278 (290) alignment 
Range on Protein: 328-570
Range on HMM: 32-278/290.0
FDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPD
 .... .||. |||.  .|||| .||.|    .. |||||||.||   ... ...|.|.|| .|..|||||.||..   |||. .  |. | . ..  |.
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

KGEFVV-YGLLMVEVESEERQE-GYIKRQLKISNTksSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqTGNGPITVHCSDGSGRTGTFCAIS
.||  . .| . |..|.|.. . ... |.||. .   .| |.|  |.|..||. |||.  | ........ . |. . . |. |||| | ||||| .|| 
egeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaid

IALERVKLDAT---IDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
.. | .| . .   .|.|. |..||.||. .||| |||.. |. | ..|.
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN1_pd Subfamily PTPN1 328-565 8.6e-49 160.8 In-house 24-267 (290) alignment 
Range on Protein: 328-565
Range on HMM: 24-267/290.0
FDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGvlgsDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPD
  .| .|||...||.  | ||| .|.||         ||||||...  . .  .. || ||  |.. ||.|.|| .| .||||||  |. ...  |  | 
treaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

KGE--FVVYG--LLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQ-QTGNGPITVHCSDGSGRTGTFC
. |   ...    | |.. ||||.. |. |.|.. | |. | |...|| |  ||. |||.     ...| .. ..   ..  ||  .||| | ||.||||
geeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc

AISIALERVKL---DATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
 .   | ...     ...|. ... .|| .|  ..||..| .| |  .
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
0049772 (Phosphotyrosine protein) phosphatases II 328-572 4e-42 140.4 In-house 38-283 (314) alignment 
Range on Protein: 328-572
Range on HMM: 38-283/314.0
FDSASMPENKSKNRFL-VLPYDrTRVKLwPYPGVLGSDYINASFIDSYqqrEAFLATQAPLETTINDF----------WRML--WEYESYTVVM------
.  |. ..|..|||.| .||.| .||.| |. .| ||||||||..|..    .|.|||.||| |..||          |||   ... . ..||      
ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LNKDSENIkvrlkqtpdkGEFVVYGLLMVEveseerqegyikrqlKISNTKSSEVRNVFHFQYEDWPEDGVPqDGKLVIDMLKHI
               |.. ..|           .| ..  | . .               .. . ..   |..... . ..| ...| . . . ..|..|
adelsrLdaAlgKtpllildgng..........neptaadlellk...............eelydpelferlgikylripvpDgsap.lledfdeflefi

ARAqqqTGNGPITVHCSDGSGRTGTFCAISIALERVKldatIDMFQTVRNLRTQRP-----IMVQTPEQYKFCYEVVRHFVEAF
 .|     .||. |||..| ||||||... . . . .    ... .... .| .||      .....||| |..|....... .
eea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
0042113 (Phosphotyrosine protein) phosphatases II 329-569 1.1e-75 249.5 In-house 2-243 (245) alignment 
Range on Protein: 329-569
Range on HMM: 2-243/245.0
DSASMPENKSKNRF-LVLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKG
..|. ||||.|||.  .||||.||||| |..| |.|||||||..| |.. . |.|||.||. |..||||||||. . |.|||... |. .|   |    |
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

EFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALE
|...|| ..|.. |||  ..|. |.|...|....|.|.|.|..| .||..||| . .|..|.|. . .|.....|||. ||||.| ||||||.|. ..||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
...   .......|. || ||| .||||.||.|.||......
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 329-568 1.7e-66 219.5 In-house 3-241 (243) alignment 
Range on Protein: 329-568
Range on HMM: 3-241/243.0
DSASMPENKSKNRFL-VLPYDRTRVKLwpyPGvlgSDYINASFIDSYQQreaFLATQAPLETTIND----FWRMLWEYESYTVVMLNKDSENIKVRLKQT
  |..|||.||||.  .||||..||||   .|   ||||||..|. . .   . |||.||. |..|    |||||||. . ..|||... |. ..   | 
siallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

PDkGEFvVYGLLMVEVESEERQEGYIKRQLKISNTK-SSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQ-------TGNGPITVHCSDGSGR
   ||. .|| ..|.. |||  ..|. | |...|.. . ..|.|.|..|  ||. |||.. . ..|.|...   ...        ..||. |||| | ||
wp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTFCAISIALERVkldaTIDMFQTVRNLRTQRPI-MVQTPEQYKFCYEVVRHF
|||..|. . |...    ..|....|. ||.|||  .||||.||.|.||.....
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 329-570 1.3e-55 183.4 In-house 21-269 (274) alignment 
Range on Protein: 329-570
Range on HMM: 21-269/274.0
DSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLG-SDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRL-KQTP
.  ... ...|||.  .|| ...|| | .  .    |.|||| .|  |..  .|..||| || .|..|||||... |.  .||| | .|. . .  .  |
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

DKGEF---VVYGLLMVEVESEERQEGYIKRQLKISNTKSseVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTG--NGPITVHCSDGSGRTGTF
|. ..     || . ..||.  ....|  |.| ......   |.| |. | |||.  .|.| . ..|..... ......    .|. |||| | |||| |
daedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

CAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
 |||||. ... . ..|....| ||| .|  |||| |||.. .... ....
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 329-565 9.2e-24 79.1 In-house 12-255 (290) alignment 
Range on Protein: 329-565
Range on HMM: 12-255/290.0
DSASMPENKSKNRFLVLPYDRTRVKLWPYPGVLGSDYINASFIdSYQQREAFLATQAPLET-------TINDFWRMLWEYESYTVVMLNKDSENIKV-RL
..  . ... ..|  |     ||| |  |   . .||| |... .. .  ....||.|.|        ||..|| |  . ..  |||| . .|. .   |
ktdyvkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl

----KQTPDK-GEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVrNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAraQQQTgngPITVHCSDGSGR
    |  |.. || . .. | |.  | | ... ..|.| .   .  |   | | ....| .  |..| |.........   ...|   |. ||| ||  |
faCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvk..askt...pvivHcvdGiSr

TGTFCAISIALERVK-LDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
  .. || ..   .  .   . . . . .|| ||  ........ |   ..
sAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 329-375 3.1e-07 24.1 In-house 40-87 (440) alignment 
Range on Protein: 329-375
Range on HMM: 40-87/440.0
DSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQ
| ||.|.|| |||.  .| ||..|| |    ||  |||||||.|.. .
diaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 331-577 1.1e-77 255.7 In-house 4-250 (250) alignment 
Range on Protein: 331-577
Range on HMM: 4-250/250.0
ASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTP-DKGE
|  |.|| |||.  ....| .|| | .  |   ||||||||...|..|.||.|||.||..||.|||||..|..| |.|||.. .|. |.  .  | .| |
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

fvVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALER
   || ..|.. |.|    |.||.||.|..| .. | | ....  ||. |||.  . |...||.. . |||.||.|. |.|| | ||.|.|.||.  |||
..kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

VKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYAN
.| . ..|.|. .. ||..|| .|.. ||| |.||.. .......|||.
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 331-569 3.2e-60 198.8 In-house 43-284 (297) alignment 
Range on Protein: 331-569
Range on HMM: 43-284/297.0
ASMPENK---SKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQreAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDK
. . |.|   .|.|.  .||||. ||||        |||.||||. ....   ...|| | ..|..|||.|.....  |.||||.|.|. |   .  .||
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk

GEFVvYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQ--DGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISI
|    .| . |...| ...||.|||.|.... |.   | |  .|. .||.. |..  . . ...... .    .|. .||. |||. | |||| ...|  
gvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

ALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
 . ..| . ..|.|..|. || .|| .||| ||||| |..|  ..
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 331-417 3.1e-14 47.5 In-house 42-143 (350) alignment 
Range on Protein: 331-417
Range on HMM: 42-143/350.0
ASMPENKSKNRFL-VLPYDRTRVKLW--PY------PGVLGSDYINASFIDSY----QQREAF--LATQAPLETTINDFWRMLWEYESYTVVMLNKDSEN
..  |  .|||.  .|||...||||   .         . ..|||||...       ..   |  .||||||  |..||.... . .   ...|..| |.
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

IK
  
nl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 332-571 5.3e-56 184.6 In-house 16-266 (270) alignment 
Range on Protein: 332-571
Range on HMM: 16-266/270.0
SMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSY-QQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLK----QTPD
..  .|  ||.  .||  .|||.| .      . |||| ..  . .......|...||.||...||||.|| .. ..||. .  |. . . .    . |.
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

KGEFVVYGLLMVEVESEERQEGYIKRQLKISntKSSEVRNVFHFQYEDWPEDGVPQDGK------LVIDMLKHIARAQQQTGNG-PITVHCSDGSGRTGT
.   . .| . | ..|||..||||...|..   ...| |.. ||.|..||..|||..         .. ||... | .... .. |. ||||.| |||||
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

FCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEA
. |. ||.. .. .  .|. . ...|| .|. .||.||||.| |..|....| 
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_eak_pd Subfamily eak 332-481 7.5e-17 55.7 In-house 48-196 (332) alignment 
Range on Protein: 332-481
Range on HMM: 48-196/332.0
SMPENKSKNRFLVLPYDRTRVKLWPYPgVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSE-NIKVRLKQTPDKG-EF
.  |.  .| . ..||||  |.| .        ||||| ..  .  . .. | .. |. .  ||.|. |  | ..|.| .| | ...   |  |||. | 
arleavnrnvvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

VVYGLLMVEVESEERQEGYIKRQLKISntKSSEVRNVFHFQYEDWPEDGVPQ
. .| | ||  .  ... .  |.|..|  |  |  .|.|...  | |  .|.
lkfGildverkefvkrniletrllels..kGnethrvlhykvfGwtettlpk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 332-404 2.1e-07 24.8 In-house 37-111 (347) alignment 
Range on Protein: 332-404
Range on HMM: 37-111/347.0
SMPENKSKNRFLVlpyDRTRVKLWPYPGVLG-----SDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESY
|.  |.||.  |.   | ||| | |     .       ||||| |   . .. .. || ||  |. |||.|.      
slsknrskdvkli...datrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 333-571 3.8e-33 109.4 In-house 51-285 (290) alignment 
Range on Protein: 333-571
Range on HMM: 51-285/290.0
MPENK--SKNRFL-VLPYDRTRVKLWpyPGVLGsDYINASFIDSYQqrEAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPDK-G
. .|    |||.  |   |.||| |    |  | ||. | ...  .    |. || .|. |. |.|||. . .  ..||| .  |. | . .|  |.| |
fdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

EFVVYGLLMVEVE-SEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAqqqtgNGPITVHCSDGSGRTGTFCAISIAL
| . .| . |    ......  ||. | . . .|     . |..   ||.  |..    .. .|. . .|     .||..|||| | |||||| || ..|
evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievgl

ERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEA
. .     .|. ..|| ||  |   ||   ||    |.. ..  .
qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkd
subfamily_CG7180_pd Subfamily CG7180 334-573 2.3e-55 182.4 In-house 40-294 (296) alignment 
Range on Protein: 334-573
Range on HMM: 40-294/296.0
PENKSKNR-FLVLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKGeFVVY
 ||. |||   |.||| .|| |    |   ||||||...||. . .... |.|| . |...|||.... |. .||.| |  .  |  ..  | |.    |
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks.keqy

GLLMVEVESEERQEGYIKRQLKISNT----------KSSEVRNVFHFQYEDWPE-DGVPQDGKLVIDMLKHIARAQQQT----GNGPITVHCSDGSGRTG
| ..||. .|.      .|..|.  .           . |.| | .||.  |.  | ||   . .|.... .   ....     .||. |..|||..|.|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

TFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFS
 ..|| ..|| |. .  .|.|. |. || .|| .|.. |.||..|.|. ..| .. 
vylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 335-563 1.6e-41 137.0 In-house 7-235 (239) alignment 
Range on Protein: 335-563
Range on HMM: 7-235/239.0
ENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQT-PDKGefVV
 ||.|||.  .. ||..|| |        |||||||..  |.   .|..|||  .|..  |||||.|.     .|||    |  | . .|  ||      
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sk

YGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAqQQTGNGPITVHCSDGSGRTGTFCAISIALERVKL
|  | | .   |    || | . .|.   .| | |.....  ||. ||||    |. . ..|..     |  |  .||| | ||||.|  |   | . | 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtgaflvidamlrqakk

DATIDMFQTVRNLRTQRPIMVQTPEQYKFCYE
. |.|.|. |. .| .|| |||| ||| | . 
qktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 335-564 1.9e-41 136.8 In-house 6-235 (239) alignment 
Range on Protein: 335-564
Range on HMM: 6-235/239.0
ENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQT-PDKGefVV
 ||.|||.  .. ||..|| |        |||||||..  |.   .|..|||  .|..  |||||.|.     .|||    |  | . .|  ||      
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sk

YGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAqQQTGNGPITVHCSDGSGRTGTFCAISIALERVKL
|  | | .   |    || | . .|.   .| | |.....  ||. ||||    |. . ..|..     |  |  .||| | ||||.|  |   | . | 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtgaflvidamlrqakk

DATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
. |.|.|. |. .| .|| |||| ||| | .  
qktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 335-564 5.5e-41 135.3 In-house 2-234 (237) alignment 
Range on Protein: 335-564
Range on HMM: 2-234/237.0
ENKSKNRFL-VLPYDRTRVKLWPyPGVlGSDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPDKGEFVV
||| |||.  .  || .|| |   .|  |||||||.......     ..|.| |||.. .|||.|.|.     .|||    |. ... ..  |.  .   
enkiknrygnivaydhsrvvlkg.ags.gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGLLMVEVESEERQEGYIKRQLKISN-TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIA-RAQQQTGNGPITVHCSDGSGRTGTFCAISIALERV
|| | | .  .|    |  | | .|. ..  ||| .. .|.  ||. ||||    .. . |.|  |..  .  ||  .||| | |||| |  |   | . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
|    .|... | ..  .|| ..|| .|| | ...
kekkvvdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 335-568 3.5e-27 90.2 In-house 42-270 (288) alignment 
Range on Protein: 335-568
Range on HMM: 42-270/288.0
ENKSKNRFLVLPY-DRTRVKLWpypgVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TP-DKGEFVV
.| ...|.  ||  | |||||          ||.|  . | . .. .. .||||..||. .|.|| | .   .|||..  |  | . ..  |  .|| . 
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGLLMVEVESEErqeGYIKRQLKISN---TKSSEVRN-VFHFQYEDWPEDGVPQDGKLVIDMLKHIaraqqQTGNGPITVHCSDGSGRTGTFCAISIALE
.| |   |  .      |.. .|.|    .|  | .  | .  . .|..||||.. .  . .|. .     .. . || ||.| |.|||||.  | ||||
igrlctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililiale

RVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
 ..||  . . . . .|| .|   .||  || . . .| . 
slrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 335-568 1.7e-20 67.9 In-house 46-278 (303) alignment 
Range on Protein: 335-568
Range on HMM: 46-278/303.0
ENKSKNRFL-VLPYDRTRVKLwpypgvLGSDYINASFIDSYQQREAFLaTQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPDKGEFVVY
.|  ||||  |.  | ..|||        | || ||...   .. | | || ||  |  |||.|. |     |..|  |||  |.  .   | . .|. .
knmdknrfvdvicldhskvkl......sdssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GLLMV---EVESEERQEGYIKRQLKISNTKSSEVRNVFHfqYEDWPEDGVPQD--GKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIAL-
   ..   |    |  .|.  . | .|| .      | |  |..|| . .| |   |.| .. .  .  .. . . |       | ||.|||. .  |  
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhh..ykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

ERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
   . .|..|. . . |.|  |   ||   |. . | ..   
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 335-492 3.4e-06 20.1 In-house 26-167 (169) alignment 
Range on Protein: 335-492
Range on HMM: 26-167/169.0
ENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINAsfidsyqqreaflatqaplettindfwRMLWEYESYTVVMLN-KDSENI------KVRLKQTPDK
 |..|||    |   .|||||      ||||||||                           ||.|| ..  .|.|   |  |         .|. .   
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

GEFVVYGLLMVE--VESE-ERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKH
||.    | .    |..  .  || ..  . | . ...   ..  ..|  ||..||||    |  ...|
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvghlfhh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 335-492 4.2e-06 19.7 In-house 25-166 (169) alignment 
Range on Protein: 335-492
Range on HMM: 25-166/169.0
ENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINAsfidsyqqreaflatqaplettindfwRMLWEYESYTVVMLN-KDSENIK------VRLKQTPDK
 |..|||    |   .|||||      ||||||||                           ||.|| ..  .|.|   |  |         .|. .   
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil

GEFVVYGLLmVEVESE----ERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKH
||.    |  |  .         || .. .| | . ...  ...  ..|  ||..||||    |  ...|
Gewytdsly.vrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvghlfhh
Y_phosphatase Protein-tyrosine phosphatase 336-565 7.9e-72 236.8 Pfam-A 1-233 (235) alignment 
Range on Protein: 336-565
Range on HMM: 1-233/235.0
NKSKNRF-LVLPYDRTRVKLwpyPGVLG-SDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTP--DKGEFVV
||.|||.  .||||.|||||    |  | ||||||.....|.. ..|.|||.||. ||.|||||.|.... ..|||... |. .. ..|    ...|.. 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGLLMVEVE-SEE-RQEGYIKRQLKISNTKSS-EVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQqQTGNGPITVHCSDGSGRTGTFCAISIALER
|| . ||.. .|.  ...|. |.|.....|.. | | | ...|..||. |||.. | ..|... . . . .. .||..||||.|.||||||.|..|.||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

VKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
.. . ..|..|.|..||.||| |||. |||.|.|...
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 336-565 7.9e-72 236.8 In-house 1-233 (235) alignment 
Range on Protein: 336-565
Range on HMM: 1-233/235.0
NKSKNRF-LVLPYDRTRVKLwpyPGVLG-SDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTP--DKGEFVV
||.|||.  .||||.|||||    |  | ||||||.....|.. ..|.|||.||. ||.|||||.|.... ..|||... |. .. ..|    ...|.. 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGLLMVEVE-SEE-RQEGYIKRQLKISNTKSS-EVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQqQTGNGPITVHCSDGSGRTGTFCAISIALER
|| . ||.. .|.  ...|. |.|.....|.. | | | ...|..||. |||.. | ..|... . . . .. .||..||||.|.||||||.|..|.||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

VKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
.. . ..|..|.|..||.||| |||. |||.|.|...
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 336-567 1.8e-62 206.1 In-house 43-274 (515) alignment 
Range on Protein: 336-567
Range on HMM: 43-274/515.0
NKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRL-KQTPD-KGEFVVY
| .|||.  .||||..||||        |||.|||.| |..   |..|.|.|......||||......  |..|..| .|. |..  |  ||  |. | .
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GLLMVEVESEERQEGYIKRQLKIsnTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGnGPITVHCSDGSGRTGTFCAISIALERVKLD
| . ||. | |   | |||.|..  .|....| |  |....||. |||.. . .. ..| .   ..|    |. .||| | |||| ...|   . ..|  
Gsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahaktt

ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRH
 ..|.|..|.|.| .|| .||| ||| | |..|. 
rmvdvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 336-566 2.2e-49 163.1 In-house 48-276 (439) alignment 
Range on Protein: 336-566
Range on HMM: 48-276/439.0
NKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKvrlkQTPDKGEfVVYGL
...|||.  | ..| ||| |   |||  | |||| .|. | . . ..|||.| . | .||||...|  . |.||| .  |  |      | ..| |.|| 
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdae.vcygd

LMVEVESEERQEGYIKRQLKISNTKS--SEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLD
..| |. .     |. | .|. | .      | |..|.|  ||.  || .   |.|.|. |  |...   ||. |||| | |||||  |. ||||..||.
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkle

ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
  .|.   |. || ||  |||.  || | |. | 
nkvdikgivkvlrkqrkqmvqalcqyvfiynavl
0041856 (Phosphotyrosine protein) phosphatases II 336-568 1.5e-42 140.6 In-house 1-170 (182) alignment 
Range on Protein: 336-568
Range on HMM: 1-170/182.0
NKSKNRFL-VLPYDRTRvklwpypgvlGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNkdseN----Ikvrlkqtpdkgefv
|..|||.  .||||..|          ..|||||.......    |.|||.||  |..||.|||.|.   |.|.|.    .                   
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywp..............

vygllmveveseerqegyikrqlkisntkSSEVRNVFHFQYEDWPEDGVPQdgklVIDMLKHIARAQQqtGNGPITVHCSDGSGRTGTFCAISIALERvk
                             . . |......|  || .|||     . ..|. | ....   .||. |||| | |||||..|. . ...  
.............................ellerlgiqylylpwpDhgvpd....ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl..

ldaTIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
    ......|. .| .|| ||.||.|| |.. .....
...gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 336-558 3e-31 103.3 In-house 50-270 (301) alignment 
Range on Protein: 336-558
Range on HMM: 50-270/301.0
NKSKNRFLVLPYD-RTRVKLWPYpGVlgSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ--TPDKGEFVVY
.| |.|.  .| .  | |..    |      | | .|..  . . |.|||.||. | .||| ||  |.  ..||| .  |. . . ..  . . .| .  
pkdkhryptvPckPstavevivd.Gk..rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GLLMVEVESEER--QEGYIKRQLKISN-TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqtgngPITVHCSDGSGRTGTFCAISIALERV
|  .......|   ..  .||.|.. . |.  . | | |.||..|.. |||.    . |... . ....     || ||||.| ||. .| .  .   .|
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylarev

KLDATIDMFQTVRNLRTQRPIMVQTPEQY
. | ||.. .....|| .|   ||| .| 
eadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 336-571 2e-18 61.1 In-house 43-278 (312) alignment 
Range on Protein: 336-571
Range on HMM: 43-278/312.0
NKSKNRFL-VLPYDRTRVKLWPYpgvlGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVR-LKQTPDKGEF----
 |  ||.  .  .|| |  |          || | |.    . | |..||.||| |.  ||..     | ....|    |.   .  |   |   |    
fkdlnrypniqcwdrgrftlagd....enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

--VVYGLLMVEVESEERQEGY-IKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqtgngPITVHCSDGSGRTGTFCAISIAL
   ||     |.|   .      .| ||.    . .  .. |.|.  ||. |.|.       .|  . . ..     |.  ||| | |||||.. |   .
dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmi

ERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEA
  ..     .. ..   || .|   |..  || ..  .| .|. .
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 344-411 1.5e-07 25.2 In-house 43-109 (332) alignment 
Range on Protein: 344-411
Range on HMM: 43-109/332.0
VLPYDRTRVKLWPYPGVlgSDYINASFIDSYQQREAFLATQAPLET-TINDFWRMLWEYESYTVVMLNK
.  .|..||.| |  |    |. |||..| | .. |.. .|||..  |   ||||. | .   ....  
lycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 345-479 2.5e-10 34.8 In-house 3-126 (130) alignment 
Range on Protein: 345-479
Range on HMM: 3-126/130.0
LPYDRTRVKlwpypgvlGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIkvrlKQTPDKGEFVVYGLLMVEVESEER
|... .|..        | .||||||.   ..   .| ||.||  |  |||.|. |     .|.|    |.     .  ||   .  |   ..   ..  
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrd

QEGYIKR-QLKISNTKSSEVRNVFHFQYEDWPEDGV
.  .||  .|.|..      . .  ||  .|| || 
efknikasnleiesdlneshqaltmfqisnwpsdgt
0044763 (Phosphotyrosine protein) phosphatases II 346-567 1.1e-33 111.7 In-house 1-169 (178) alignment 
Range on Protein: 346-567
Range on HMM: 1-169/178.0
PYDRTRVKLWPYPGVLGSDYINASFIDSYqqreaFLATQAPLettiNDFWRMLWEYESYTVVMLNKDSENIKVRL-KQTPDK-Gefvvygllmvevesee
|.|||||.|....|...|||||||.|. .     ......|      |....|.|.   ..|.|... |. .. . .. |.. |                
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

rqegyikrqlkisntkssevrnvFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqTGNGPITVHCSDGSGRTGTFCAISIALERvkldaTIDMFQTVRN
                       .....  .| .|||.  . . .... | .|.. . .||. |||| | ||.||..|. . ...      ..... .. 
.......................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

LRTQRPiMVQTPEQYKFCYEVVRH
.| .|| .|..|.|....||. ..
vrerRp.ivpnpgqlrqLyefelr
0046846 (Phosphotyrosine protein) phosphatases II 357-568 4.7e-38 126.0 In-house 6-172 (176) alignment 
Range on Protein: 357-568
Range on HMM: 6-172/176.0
YPGVLGSDYINASFIDSYqqreAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDK-----Gefvvygllmveveseerqegyikr
.   |..|||||..|...    ...|||.||. |. ||..||.|.  ..||.|... |  .... . ..                               
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

qlkisntkssevrnvfHFQYEDWPEDGVPQDgKLVIDMLKHIARAQQQTgnGPITVHCSDGSGRTGTFCAISialeRVKLDATIDMFQTVRNLRTQRP-I
                .... .||. |||.. .|....|. | .|...   ||. |||| | |||||..|.      ..|.  ........ .| |||  
................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplg

MVQTPEQYKFCYEVVRHF
.|||||||.|.||.....
avqtpeQyrflyefelll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 360-415 8.2e-07 22.6 In-house 87-144 (349) alignment 
Range on Protein: 360-415
Range on HMM: 87-144/349.0
VLGSDYINASFIDS--YQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSEN
    ||||| ..    ..  . ..|||||| .|..||....   .   |. ||.| |.
gklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel
0036282 (Phosphotyrosine protein) phosphatases II 362-563 4.2e-44 145.6 In-house 1-164 (174) alignment 
Range on Protein: 362-563
Range on HMM: 1-164/174.0
GSDYINASFIDSYQQREAFLATQAPLEttindFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKgefvvygllmveveseerqegyikrqlkisnTKSS
||||||||..| .   . ..|.|.||.     ||.||.|. . |||||..  |. ...  .                                   ....
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EVRNVFHFQYEDWPEDGVPQDGKlVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKlDATIDMFQTVRNLRTQRPIMVQTPEQYKFC
..|......|  || .||| . . .....| . .|... ..||. |||| | |||||..|. . | . .   ..| ...|| ||.||| |||||.||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YE
|.
yy
0043147 (Phosphotyrosine protein) phosphatases II 362-564 1.7e-43 143.6 In-house 4-156 (172) alignment 
Range on Protein: 362-564
Range on HMM: 4-156/172.0
GSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDsenikvrlkqtpdkgefvvygllmveveseerqegyikrqlkiSNTKSS
||||||||..| |     |.|||.||  |..||||||.|.   ..|.|..                                             .... 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

EVRNVFHFQYEDWPEDGVPqDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALervkldATIDMFQTVRNLRTQRPIMVQTPEQYKFC
..|......|  ||  ||| . .|....|. | .....  .||. |||| | |||||..|. . |        ......|. .|..||..||.|.||.|.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

YEV
|. 
yyf
0051429 (Phosphotyrosine protein) phosphatases II 363-572 1.6e-49 164.3 In-house 4-228 (272) alignment 
Range on Protein: 363-572
Range on HMM: 4-228/272.0
SDYINASFIDSYQQ---REAFLATQAPLETTINDFWRMlWEYESYTVVMLNKDSENIKVR-LKQTP-----------DKGEFVVYGLLMVEVESEERQEG
|.||||.... | .   . .......||. |..||||. .|.   |.|.| ...|  ..   .  |           |  ... || |.| . ||| .. 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YIKRQLKISNT-KSSEVRNVFHFQYEDWPEDGVPQDGklVIDMLKHIARaqqqtgNGPITVHCSDGSGRTGTFCAISIALERVKLDATID--------MF
|| | | .... . .|.| |.|..| ||| .||||.   ....|.....      .||. |||| | .||||..|. . |..| |.. .|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAF
..|. || ||| .|||.|||.|.||.........
eaveelraqrpgavqteeqylflyeallellrsl
0051082 (Phosphotyrosine protein) phosphatases II 363-564 5.5e-35 115.5 In-house 3-148 (151) alignment 
Range on Protein: 363-564
Range on HMM: 3-148/151.0
SDYINASFIDSYqqreaFLATQAPLEttinDFWRMLWEYESYTVVMLNKDSENIkVRLKQTPDKGefvvygllmveveseerqegyikrqlkisntksse
|||||.|.....     ......||.    ||...|.|.  .|.|.|... |.     .  |. |                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................

vRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARaqqqTGNGPITVHCSDGSGRTGTFCAISIALERvkldatIDMFQTVRNLRTQRPIMVQTPEQYKFCY
 ..|.|....|||. |.|.  . |...|.....    ..|||. |||| | |||||..|. . |..      ........ .| .|| .||...|. |..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

EV
 .
fa
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 363-567 1.1e-27 91.7 In-house 59-268 (285) alignment 
Range on Protein: 363-567
Range on HMM: 59-268/285.0
SDYINASFIDSY-QQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSEN--IKVRLKQTPDKGEFVVYGLLMVEVE--SEERQEGYIKRQLKISN
 ||| ||..    ... ....|| ||  |..|||.|... .   |.||    |    |. |      || | .|   . .    ||   | |   | . |
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvin

TK--SSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQtgNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTP
|.  |||   . | |   ||..  |.| . .|.. | . . . .  . || |||| | ||| ||  |  |  |.  .  |.|.. ||..|. |   ||. 
tedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqsh

EQYKFCYEVVRH
 |. | | |.  
mqflflyvvlme
0049260 (Phosphotyrosine protein) phosphatases II 370-563 4.5e-37 122.4 In-house 1-144 (152) alignment 
Range on Protein: 370-563
Range on HMM: 1-144/152.0
FIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPdkgefvvygllmveveseerqegyikrqlkisntkssevrnvfHF
||| | .  .|.|||.|.. |..||||||.|.   |.|||....|. |.  .| .                                           ..
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QYEDWPEDGVPQDGKLVIDMLKHIARAqQQTGNGPITVHCSDGSGRTGTFCAISIALervkldATIDMFQTVRNLRTQRPIMVQTPEQYKFCYE
..  || .|||..  |....|. | .. ..  .||. |||| | |||||..|. . |        ......|. .|..||..|..|.|..|.||
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 372-412 6.9e-10 32.8 In-house 230-270 (440) alignment 
Range on Protein: 372-412
Range on HMM: 230-270/440.0
DSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKD
. | ...||.||| ||..|. ||||.. .|.  |..|||. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnql
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 378-564 2.1e-24 80.8 In-house 5-199 (199) alignment 
Range on Protein: 378-564
Range on HMM: 5-199/199.0
EAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKV--RLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISN--TKSSEVRNVFHFQYED
  ..||| ||  |. |||.|.||  |  .||.| |  | ..   .     .     || | | ...   .  |    | ..|  |     |.. |.|.  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEDGVPQDGKLVID--MLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKL--DATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
| |   |.   .|      . ...  .|  . |. |||||| | || | |. | .   .    . .|.|.  . ||  |  .. . ..|.| |.|
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 378-564 2.4e-24 80.6 In-house 4-198 (198) alignment 
Range on Protein: 378-564
Range on HMM: 4-198/198.0
EAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKV--RLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISN--TKSSEVRNVFHFQYED
  ..||| ||  |. |||.|.||  |  .||.| |  | ..   .     .     || | | ...   .  |    | ..|  |     |.. |.|.  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEDGVPQDGKLVID--MLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKL--DATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
| |   |.   .|      . ...  .|  . |. |||||| | || | |. | .   .    . .|.|.  . ||  |  .. . ..|.| |.|
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 386-560 4.2e-14 46.7 In-house 99-279 (302) alignment 
Range on Protein: 386-560
Range on HMM: 99-279/302.0
PLETTINDFWRMLWEYESYTVVMLNK--DSENIKVRL---KQTPDKGEFVVYGLLMVEVESEERQ----EGYIKRQLKISNTKSSE--VRNVFHFQYEDW
|   |.. .| .. .|.   || | .  ..|. |.     ..  .. .|  | .  |.|. .  .    ...   ...| |.|  .   . |  ...  |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PEDGVPQDGKLVIDMLKHIARAQQQtgngpITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKF
|. | |.. .  .|.||.    ...     . |||| | |||||. ||   ..  . . . |. . |  .|. |   ||. .|  .
pdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 386-569 6.6e-07 22.2 In-house 126-309 (346) alignment 
Range on Protein: 386-569
Range on HMM: 126-309/346.0
PLETTINDFWRMLWEYESYTVVMLNKDS--ENIKVRLKqTPDKGEFVVYGLLMVEVESEER---QEGYIKRQLKISNTKSsEVRNVFHfqYEDWPEDGVP
  |. ..||| |... .   | ..  |    |    |    ..| .   | ....    .       |    |   |. |  . .| |  .  |     |
enesfvedfwymiyqeqihlvylmvpddklkntttslf.ndenggyqytgkmfinnrradvsgdpkeytievlpegnsds.vicqvhh..hapwkhlqqp

QDGKLVIDMLKHIaRAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
     .| |.. .  ...|  |  . |    |.||. .|     |....      .... ..|.. |||  |..  ||   | .|  ..
pktlpiikmihqf.lsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_hpo-7_pd Subfamily hpo-7 387-569 2.5e-12 41.3 In-house 43-227 (263) alignment 
Range on Protein: 387-569
Range on HMM: 43-227/263.0
LETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKS--SEVRNVFHFQYEDWPEDGVPQDGK
|  ||. |....   .. .||||    |. ... ..           |  |.| . . |.  ... |.. .| .   ....| |..|  |.|   |.. .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

LVIDMLKhIARAQQqtgngPITVHCSDGSGRTGTFCAISIALER--VKLDA----TIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
 .. .|| .||  .     .. |||| | ||.  |  . ..  .    ||      .|  . ...|| .|.  ..|| |  |   .|  ||
eilnilk.varnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 390-569 3.4e-14 47.6 In-house 40-221 (255) alignment 
Range on Protein: 390-569
Range on HMM: 40-221/255.0
TINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKS--SEVRNVFHFQYEDWPEDGVPQDGKLVI
|.. |....   .. .||||    |. ... ..           |  |.| . .     . | |.|  | .   . ..| |..|. |.|   |.. . . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DMLKHIARAQqqtgngPITVHCSDGSGRTGTFCAISIALERV--KLD----ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
 .|| .  ..      .. |||| | ||. .|  . ..  ..   ||    . .|  . ...|| .|.  ..|| |  |.  .|  .|
nilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048076 (Phosphotyrosine protein) phosphatases II 437-567 7.3e-26 86.0 In-house 18-141 (145) alignment 
Range on Protein: 437-567
Range on HMM: 18-141/145.0
VEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQtgNGPITVHCSDGSGRTGTFCAISIALErvkldATID
. .. |. ..  |.. | ...... ..|......| .||  |||.. .|....|. | .|...  .||. |||| | |||||..|. . |.       ..
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll.....lgvs

MFQTVRNLRTQRPIMVQTPEQYKFCYEVVRH
...... .|.|||..|..|.|..|.||....
leealelvrsqrpgavpnpgqlrflyefele
Y_phosphatase3 Tyrosine phosphatase family 442-532 2.7e-06 22.5 Pfam-A 76-154 (164) alignment 
Range on Protein: 442-532
Range on HMM: 76-154/164.0
EERQegyIKRQLKISNTKSSEVRNVFHFQYEDWPEDGvpqdGKLVIDMLKHIARaqqqTGnGPITVHCSDGSGRTGTFCAISIALERVKLD
||..    ...|. . ....| .. ..  |.. .||      | . ..|...|.    .  ||. .||. |  ||| ..|.  .|  |. .
eeae...speelaerlkeaeeaeeamaeayreilede....kkayrkvlealae....ee.gpvlfHCtaGKDRTGvvaalllsllgvdee
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 455-566 7.4e-25 82.2 In-house 80-191 (440) alignment 
Range on Protein: 455-566
Range on HMM: 80-191/440.0
ISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQT
 |  .. | | . ...|. ||. |||.    |. |.. .  .|...||||. |||| |.||||   |.   |  .|    ||.|  . ..| .|| ||||
asyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqt

PEQYKFCYEVVR
|||| | .|.| 
peqyafvheavl
0048179 (Phosphotyrosine protein) phosphatases II 458-563 1.8e-23 78.3 In-house 41-139 (144) alignment 
Range on Protein: 458-563
Range on HMM: 41-139/144.0
TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqtGNGPITVHCSDGSGRTGTFCAISIALervklDATIDMFQTVRNLRTQRPIMVQTPEQ
 . .. |....... .||  |||.. .|....|. | .|..   .||. |||| | |||||..|. . .        ........ .|..||..|..|.|
epefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgq

YKFCYE
..|..|
lrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 461-568 2.1e-15 51.3 In-house 212-343 (350) alignment 
Range on Protein: 461-568
Range on HMM: 212-343/350.0
SEVRNVFHFQYEDWPEDGVPQDGKLVIDMLK--------HIARAQQQTGNG-PITVHCSDGSGRTGTFCAISIALE-----------RVKLDA---TID-
|.   |...|.. |.. ..  . . .. .|.         .|.   .. .. || |||| | |||||....   |.            .|||    | | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

MFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
....| .|| ||  |||. .|. |.|| ....
isiivnelrkqrismvqnldqfifiYeallfy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 465-568 8.7e-10 32.4 In-house 219-343 (349) alignment 
Range on Protein: 465-568
Range on HMM: 219-343/349.0
NVFHFQYEDWPEDGVPQDGKLVIDML---KH-----IARAQQQTGN-GPITVHCSDGSGRTGTFCAISIALE--------RVKLDA---TID-MFQTVRN
 .. .|. .|.. ..  . . ..  |   ..      ||   .| .  .. |||| | ||||... . . |.         .|..    . | .. .| .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRTQRPIMVQTPEQYKFCYEVVRHF
|| ||  |||   |. ..|| . ..
lrkqrismvqnlaqfiaiyealLky
subfamily_PTPDC1_pd Subfamily PTPDC1 465-568 9.6e-10 33.2 In-house 82-175 (182) alignment 
Range on Protein: 465-568
Range on HMM: 82-175/182.0
NVFHFQYeDWPEDGVPQDgKLVIDMLKHIARAQQQtgnGPITVHCSDGSGRTGTFCAISIALERvkldaTIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
.......  |.. ||.   . ..|. | .| | |.   | ..|||  | ||||   |  .   .      ..  .... .| .||  .|| || ... | 
giyvynf.gwkDygvasl.eriLdivkvvafalqe...gkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvkef

VRHF
  . 
alfl
subfamily_PTEN_pd Subfamily PTEN 465-561 2.8e-06 22.5 In-house 81-172 (184) alignment 
Range on Protein: 465-561
Range on HMM: 81-172/184.0
NVFHFQYEdwpeDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAiSIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFC
.| ... .    |  |   .|. .....| .  ..  .  . |||  | ||||.  . .  |.. .|. . .. .   . ||.    |. | | .. 
rvavypfd....DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvliv.ayllkslllekaeealelfaeaRtknkkgvtiPsqrRYv
PTPc_DSPc_SM00012 468-565 7.8e-34 111.4 In-house 4-103 (105) alignment 
Range on Protein: 468-565
Range on HMM: 4-103/105.0
HFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTG-NGPITVHCSDGSGRTGTFCAISIALERVKLD-ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
|..| .||. |||.... ....|... . ... . ..|. ||||.| ||||||.|..|.|....    ..|.||.|. ||.||| |||| ||| |.|...
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
0038934 (Phosphotyrosine protein) phosphatases II 469-567 5.1e-09 31.5 In-house 80-175 (194) alignment 
Range on Protein: 469-567
Range on HMM: 80-175/194.0
FQYEDWP--EDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIAL-ERVKLDATIDMFQTVRnlrtqrPIMVQTPEQYKFCYEVV
..| ..|  .||.. . ... . |. . .  ..  .| . |||  | |||||..|  .    . .... |..|. .|      | .........  .. .
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR......pgaipnqdyleallkry

RH
..
ke
PTEN_1 476-562 1.2e-07 26.7 In-house 103-186 (196) alignment 
Range on Protein: 476-562
Range on HMM: 103-186/196.0
EDGVPQDGKLVIDMLKHIARAQQQTG-NGPITVHCSDGSGRTG-TFCAISIALERVKLDATIDMFQTVR-NLRTQrpimvqTPEQYKFCY
||  ...   ..|..| .. . ..   .. . |||  | ||.|   .|  .....   | ......  | . . .      .|.| .. .
eDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapn......spsqerlle
subfamily_DSP23_pd Subfamily DSP23 487-563 1.1e-06 23.4 In-house 71-140 (148) alignment 
Range on Protein: 487-563
Range on HMM: 71-140/148.0
IDMLKHIARAQQQtgNGPITVHCSDGSGRTGTFCAISIALERvKLDATidmfQTVRNLRTQRPIMVQTPEQYKFCYE
 .... .  |...  |  ..|||  | |||||. |  .  || || |.    ... ..| .||  |.| || |  ..
vefvrvveeaeek..neavsvhcllgrgrtgtmlacylvker.klaaa....eaiaevrrlrpgsvetveqeklvrd
subfamily_CDC14_pd Subfamily CDC14 490-562 8e-06 19.9 In-house 252-317 (328) alignment 
Range on Protein: 490-562
Range on HMM: 252-317/328.0
LKHIARAQQQTgNGPITVHCSDGSGRTGTFCAISIaLERVKLDATidmfQTVRNLRTQRPIMVQTPEQyKFCY
.|.  .. ... .| |.|||  | |||||. |  . ... .. |.    ...  ||  || .| .| | ||..
vkkfleiaeka.eGaiavhCkaGLGrtGtLiacyl.mkhyrftaa....eaiawlricrPGsvigpqq.kfle
subfamily_CG42327_pd Subfamily CG42327 494-569 3.6e-18 60.3 In-house 239-315 (319) alignment 
Range on Protein: 494-569
Range on HMM: 239-315/319.0
ARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLD-ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
.|. ..  .||..|||||| ||||.  |  ||.....    ..|. |.|  .| .|   |.| |||.| | |.  . 
srsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 501-566 1.3e-11 39.0 In-house 227-292 (297) alignment 
Range on Protein: 501-566
Range on HMM: 227-292/297.0
GNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
 | .. |||| | ||.|      . |.... .   |.   .. || ||. .||| ||....|..| 
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 506-564 1.3e-14 48.3 In-house 2-60 (69) alignment 
Range on Protein: 506-564
Range on HMM: 2-60/69.0
TVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
 |||| |.|||||| || . . |.| .  .|.|  |. .|  ||.||    .| | .. 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 507-564 9.4e-15 48.7 In-house 2-59 (69) alignment 
Range on Protein: 507-564
Range on HMM: 2-59/69.0
VHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
|||| |.|||||| || . . |.| .  .|.|  |. .|  ||.||   ..| | .. 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda