Gene NvecPTP-sf5-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP063_AA protein Get Run
NvecP063_AA_4-281 phosphatase_domain Get Run
NvecP063_AA_293-570 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-316 7.3e-163 536.1 In-house 4-319 (319) alignment
Range on Protein: 1-316
Range on HMM: 4-319/319.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
.|.|..|.|......|||......||.......|...|.. |||||.|||||||.| |.|||..|||||..|||||||.|||||..|.||||||.|..||
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVESpaREIVQYHYTAWPDHGVPTHATSLL
..||||||||...|..||.|..||..|.|..||||..|.||||||.||..|||||..|.|||.......|.||.  ||.....||.||||.||..|||||
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevet..RevkhfqyteWpdhdvPekatsll

AFIRRIRNSVSR-DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKA
....|||.|... ..||||||||||||||||.|||||||.....||..|.| .||..|.|||.|||...||.||..||.||...|.||..||||.||.|.
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq

LQSRDPDSGETYIAKEFK
|.....|.|||....||.
laekvadtgetglerefq

subfamily_PTPRD_pd Subfamily PTPRD 1-320 1.4e-150 497.6 In-house 4-321 (564) alignment
Range on Protein: 1-320
Range on HMM: 4-321/564.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
||||..|.|...  ..... .|.||. .|... .|.|... |..||.||||.|||| ||.|| .|...| .|||||||.|||||..|...||||||...|
pipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaet

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIeIANSDVESpaREIVQYHYTAWPDHGVPTHATSLL
..||||||||. .|.|||.|...|.|| ||.||||. ..|.||.|.||. |||||..|.||.| .   ... ||  ||. |.|.|.|||||||..|||||
iedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkksses..reVrqFhFtsWPdhgvpesatslL

AFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKAL
..||..|.. ..||||||||||||||||||.||.||||... .|. |||...|.. | |||.||||| ||||||.|..|| .||||| ....|..... |
dlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkL

QSRDPDSGETYIAKEFKNLDI
.. ..|.. |....||..|  
aeveedtemtgleleFqrLat

subfamily_PTPRA_pd Subfamily PTPRA 1-314 9.1e-104 341.9 In-house 13-329 (330) alignment
Range on Protein: 1-314
Range on HMM: 13-329/330.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRT-PGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSN
|.||.|| |  .|. .  || |.||| .. . | . . . . ||||| |||. ||.  |..|| .|...|.. |||||| |||||....||||.||| ..
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee

TFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIE-IANSDVESPAREIVQYHYTAWPDHGVPTHATS
| .|||||.||.  . |||.|.. || . ||..|||.     || . |.  .|..| .| .|||... ....  | ..| . |.|.|.||| |||...  
tvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIK
.| .......   . |||||||||||||||||.|||||.|...  |. ||.|.||.. ||||  ||||. || ||. .|.|    |.||..|  |  ...
mlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlq

ALQSRDPDSGETYIAKE
 |... ..  .. . .|
klynkitgtdkigleee

subfamily_PTPRB_pd Subfamily PTPRB 1-282 1.4e-103 341.0 In-house 6-287 (293) alignment
Range on Protein: 1-282
Range on HMM: 6-287/293.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPG-NFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSN
|| ..|..|. .  ..  .  |.||.  ... | . . . . ...|. ||||.||.. ||.|| ...|.. .||||||||.|.||| ...|||||||. .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA-NPEEYGRLVVTPLEEEELSHYVIRKFCIEIansdvESPAREIVQYHYTAWPDHGVPTHATS
|.|||||||||. .| |||.|..||.|| ||..|||.  .|  || . || ..||||...|||.. ||      |.  |.. |||.|.||||||| ....
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvPektkt

LLAFIRRIRNSV--SRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKC
||.|.|..|...  . ...|||||||||||||||.| || .|.....|  |||||.|.. | .||..||||.||||||.....  . 
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

0051299 (Phosphotyrosine protein) phosphatases II 1-280 5.1e-102 336.4 In-house 4-286 (288) alignment
Range on Protein: 1-280
Range on HMM: 4-286/288.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPG-NFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSN
.|.|..|..... .. .|.. ..|||  ..    .... ..|..||..||||..|.. ||.|| .| |||..|||||||..|||||. .|||||||| .|
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIAN-SDVESPAREIVQYHYTAWPDHGVPTHATS
|..||||||||.....|||.|..||.|. || .|||. ....||...|| |.||.|..|..|.....  .  | ..  |.. ..|||.|||||||.....
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
||.|.|..|.. . . ||.|||||||||||||.|.|| .|.|. ||| ||....| . | ||..||||. ||.|...||.|..
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0043336 (Phosphotyrosine protein) phosphatases II 1-278 2.2e-95 314.6 In-house 1-275 (278) alignment
Range on Protein: 1-278
Range on HMM: 1-275/278.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
||.|..|.....  . .... ...||  ...   ......|..|||.|||| .|.  ||.|| .| |.| ..||||||...||||. .|||||||| ..|
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPsANPEEYGRLVVTPLEEEELSHYVIRKFCIEIansDVESPAREIVQYHYTAWPDHGVPTHATSLL
..||||||||.|...|||.|. ||.|. ||..|||  ....||...|| |.||.|..|..|.....      ... |....|||..|||||||.. ..||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn...lgdgesrtvthyhylgwpdhgvpeslslll

AFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
 |....|. .. . ||..||||||||||||.|.|. .|.|. ||| ||..  |.. | || ..|||. ||.|...||.|
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-315 1.5e-94 311.5 In-house 5-314 (315) alignment
Range on Protein: 1-315
Range on HMM: 5-314/315.0
PIPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
|||...|  |   .... .. ||...  |     .  | . | ||| |||| ||.| |..|| .  |.  |.|||.|||||||||.....||.|||  ..
pipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvas

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAnPEEYGRLVVTPLEEEELSHYVIRKFcieiaNSDVESPAREIVQYHYTAWPDHGVPTHATSLL
 .||||.|.|. .. |||.||.||. | |..||||      ||.. ||  .||  ..| .| .        ...  ||.||.|||.||| ||| ....|.
vkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl.....svvfgdnirevvqlhytswpdmgvpkytiplm

AFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKAL
 .||...     ..|.||||||||||||||.| |||.|||.  | |.|.. |.   | .|  |||. .|| ||.|||.|.  ||.|    .   .| ..|
nlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsl

QSRDPDSGETYIAKEF
 .  ||.| | . ..|
lapspdtgstllqeqf

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-317 1.1e-77 256.0 In-house 2-314 (315) alignment
Range on Protein: 1-317
Range on HMM: 2-314/315.0
PIPVNKLAEYCQIHHSTgnKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
|||| ..  . .  . |    | |||  .  |  .    . ...| .||||.||.  |..|| .  .| .| |||||| .| .... . .||.|||   .
pipvaqfpafvnknrht..alfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPS--ANPEEYGRLVVTPLEEEELSHYVIRKFciEIANSDVespAREIVQYHYTAWPDHGVPTHATS
 |||||||...  . |||||.  |  |.||..|||   |.  |.| . |. |. |  .  |.||.   . .|.     | . |...| |||.||. ...|
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrksee...srtvtqfqftewPdkGvdkqtss

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIK
|| .|. .. .  ..  ...|||||||||||  | .| ...|. .. .||.| ||   | .|  .|||| .| ||.||..|  .  ||  .|  . |...
llklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlq

ALQSRDPDSGETYIAKEFKN
 |..    || . ..|||..
dlhtsvdgsgrskmtkefet

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-290 1.4e-69 229.5 In-house 9-294 (297) alignment
Range on Protein: 1-290
Range on HMM: 9-294/297.0
PIPVNKLAEYCQIHHSTgnKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHrnKFIATQGPVSNT
|||. ..| . |  ..|  . |.||| |. .   ..   . |  | .|.||.||.  |  || .  ..  | |||.|| |. |..|  ..|.|| |  .|
piplsdfatlvqknrht..dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkat

FDDFWRMVWEHGCSCIVMVTNIVERGKlKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVespAREIVQYHYTAWPDHGVPT--HATS
 .|||.||...  | |||...  || | ||..||.     ..| ..|. |  .| . .. |.. ..  .. .    | . ||... |||. |.   .|.|
vadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkaka...rrvvkqyqfveWPdkaverkdsass

LLAFIRRIRNSVSRDAG-PIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQ
|| .|  .|.. |  |  |..|||.||||||| .. .| .. .. .| .|||||.|.. | .|  .|||. || |.. |..||  . .|. ...
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-319 3.1e-62 205.2 In-house 3-275 (392) alignment
Range on Protein: 1-319
Range on HMM: 3-275/392.0
PIPVNKLAEYCQihHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
|||| ..  . .  .   .  | |||  .  |  .    . || |..||||.||.  | .|| .  .| || |||.|| .|....  . .||.||| . .
pipvaqfpafve..knrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

FDDFWRMVWEHGCSCIVMVTNIVERGklkcqkywpsanpeeygrlvvtpleeeelshyvirkfcieiansdVESPAREIVQYHYTAWPDHGVPTHATSLL
.|||||||...  . |.|||.. |                                                   || . |.|.| |||..|| |..|||
lddfwrmvfqenvttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssll

AFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKAL
 ||. ..    . . |...||||||||||  | .|... .  |   ||.| ||.  | .| .||||. || ||. |..|     ||   |  . |... |
kfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdl

QSRDPDSGETYIAKEFKNLD
..     . .   |||..| 
stssdGdvrskqlkefrslk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1-85 1.7e-10 34.8 In-house 5-88 (440) alignment
Range on Protein: 1-85
Range on HMM: 5-88/440.0
PIPVNKLAEYCQIHHstGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNH
|| |  .|.| |  .    ..|..|.  . .      | .   .|| ||||.||.| ||.|| . |. |.| |||||| .|.| . 
piivadfadyvqnnr..rsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingies

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-318 1.2e-122 403.9 In-house 2-318 (318) alignment
Range on Protein: 2-318
Range on HMM: 2-318/318.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCI-RTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
|.|..|..  .  ...|.  ..||.  . |.. .... .||.. || ||||.||.| |||||....|.| .||||||||.||||......||.|.|...|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIanSDvESPAREIVQYHYTAWPDHGVPTHATSLL
..|||||||| ... |||.|...|||| |...|||| ....||.|||.  || |||.||.|.| ..   .. |.  |.. |||||.|||.|||....|||
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..te.eeesrqvrqyhytsWpdegvpesgasll

AFIRRIRNSV-SRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKA
...|....   . .||||||||||||||||..|..|..|... .|. ||.|..|.. | |||.||||| ||.||.|.|.|| ..|.|| . .||..||. 
dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrire

LQSRDPDSGETYIAKEFKNL
|. .||.||.|..  ||..|
lreqdpesgttemdaefqrl

subfamily_PTPRG_pd Subfamily PTPRG 2-294 1e-109 362.3 In-house 1-301 (563) alignment
Range on Protein: 2-294
Range on HMM: 1-301/563.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCI---RTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGS-DYINANFIDGYNHRNKFIATQGPV
.||...|..    |. |.. |.|||  .    .. ..  .|| |.||| |||| |||| |..|| .|.| |. .. ||||||.||||.. ..|||||||.
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

SNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEI---ANSDVESPAREIVQYHYTAWPDHGVPT
 .||||||||.||.  . |||.||.||||. ||. |||. ..|.|| | ||  ||| |. | .|.. |.     . .     ... ||||| |||||||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLH
|..  | |...   .  ..||||||||||||||||||||||..| |. .| ||..|||. | |.|||..|||| ||||.||||.|| . ..|| . ....
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

D
.
e

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-300 9.1e-98 322.1 In-house 4-303 (305) alignment
Range on Protein: 2-300
Range on HMM: 4-303/305.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPgNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTF
| ...||.| . .... .|......  . .  . | |   ||.|| |||...|.  |. |. ..| .  . ||||||...|||....|.|..|||. || 
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

DDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE--EYGRLVVTPLEEEELSHYVIRKFCIEIANSDVESpaREIVQYHYTAWPDHGVPTHATSL
.||||...|   | |||.|..|| || ||..||| .  |  |.|...|.  .|.. | |..||..| |...| ||  | ..||. | |||||||. ||||
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkes..rtvlqyqltdWPdhGvpqfatsl

LAFIRRIRNSVSRDAG-PIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIK
| .|.|.... ..| | |..|||||||||||..|..| .|... ||. ||.|. . . | .|  |||| .|| |.|||| |  .||.|.  ...|. |..
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvn

ALQ
 |.
klk

0039614 (Phosphotyrosine protein) phosphatases II 2-284 9.4e-94 309.4 In-house 14-293 (297) alignment
Range on Protein: 2-284
Range on HMM: 14-293/297.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNfSWDHSLKEENKPKNRYQN-IVADHTRVAISELDGI-PGSDYINANFIDGYNH-RNKFIATQGPVSN
||.. |. ...... ...  ...||. .      .. ..|..|||.||||.. .  ||.|| .. .||  ..||||||...|||..  .|||||||| ..
iplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe

TFDDFWRMVWEHGCSCIVMVTNIVERGKlKCQKYWPSANPeEYGRLVVTPLEEEELSHYVIRKFCIEIansdvESPAREIVQYHYTAWPDHGVPTHATSL
|..||||||||.|...|||.|. ||.|. ||..|||.    .||...|| |..|.|..|..|.....      ... |.. ...|| ||||||| ....|
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.....ngesrtvthfqytgwpdhgvppslell

LAFIRRIRNSVSR--DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGN
| |.. .|. ...  . ||..||||||||||||.|... ||.|. ||| ||..  |.. | ||...|||. ||.|..|||.|  |...
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

subfamily_Ptp69D_pd Subfamily Ptp69D 2-299 4.3e-93 306.8 In-house 4-305 (307) alignment
Range on Protein: 2-299
Range on HMM: 4-305/307.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCIR-TPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNT
|.. .|.|  . ..   .  ...|.  .  .  . |   | |.||. ||||..|.| |.||| .... |   ||||||.|| ||....|||| |.|| .|
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

FDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDV--ESPAREIVQYHYTAWPDHGVPTHATS
 .|||||..|     |||..|. |  . ||.||||  .  .|| ..|.. .||. |.|.||.. .   . ..  .   |..||||||.|.|  || .|..
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevarg

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIK
|| .|...|.  . . .||||||||||||.|... || .|.|. .|  |||| .| . | |||..||  .||.|.. ||..  . |.|. .|.||.|.|.
llklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie

AL
 |
rl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2-282 1.9e-81 268.1 In-house 2-285 (290) alignment
Range on Protein: 2-282
Range on HMM: 2-285/290.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCIRT-PGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPG--SDYINANFIDGYNHRNKFIATQGPVS
|||.|..|. . .|..||..|...|. . .   ...  . | ..||..||..|||  |  |. . .. | .    .|||| .|.||......||||||||
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

NTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDveSPAREIVQYHYTAWPDHG-VPTHAT
||  |||...|.. ...|||.|||.| || |||.|||... ..||   .. |.||.|..|..||. ..  ||.   ......||. |.|...| |. ..|
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqt

SLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKC
.||.. .....   |  ..||||||..|||........  .... .|| .|.|  . . | |.  .|||. || .|.. .... ..
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-286 1.7e-79 261.8 In-house 2-284 (287) alignment
Range on Protein: 2-286
Range on HMM: 2-284/287.0
IPVNKLAEYCQIHHSTGNKSFKEEFMCIRT--PGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISeldgIPGSDYINANFIDGYNHRNKFIATQGPVSN
|||.|..|. .  | .||. ||. |. .      . .  |.. ..||.|||...|.  |  || .         ||||| |||||.....||....|..|
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKfcIEIANSDVESPAREIVQYHYTAWPDHG-VPTHATS
|  .||......  . |||...  |  . .| .|||. .   .|   .. |.||  ..|..||  .|. |.. ... ....||..|.|...| |....|.
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierk..levknknkagdkqqvkqyqitnWdstgkvtepqti

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTE
|| . .....   |  ..||||||..|||.....  .  ...  .||..|.|  . . | |.  .||| .||.|| |...|  ....| 
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety

0045450 (Phosphotyrosine protein) phosphatases II 3-279 5.9e-92 303.9 In-house 10-303 (307) alignment
Range on Protein: 3-279
Range on HMM: 10-303/307.0
PVNKLAEYCQIHHSTGNKSFKEEFMCIRTPG---NFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGI-PGSDYINANFI--------DGYNHRNKF
.. ||  .... . ...  ...||  ..      .......|..|||.||||..|.  ||||| .| |||  ..||||||...        |||.. .||
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf

IATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE-EYGRLVVTPLEEEELSHYVIRKFCIEIAnsDVESPAREIVQYHYTAWPD
|||||| ..|..|||||.||.|...|||.|. ||.|. || .|||. . | .||...|| |.||.|..|..|.....    | ... |.. ..|||.|||
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl..dgtgesrtvthfhytgwpd

HGVPTHATSLLAFIRRIRNSVSR--DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGA---VDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
||||..  .||.||...|. ...  . ||..||||||||||||.|... ||.|. |||    ||..  |.. | ||  .||.. ||.|...||.| 
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-316 7.5e-76 250.3 In-house 6-324 (325) alignment
Range on Protein: 3-316
Range on HMM: 6-324/325.0
PVNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFD
 | .| |. . ...  . .|  ||  . . .  .   . | ||| |||..|.|| |..|| .  ..  | ||||||...  .  .. |.|.| | ..| .
avvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

DFWRMV--WEhgcSCIVMVTNIVERGKLKCQKYWPSA--NPEEYGRLVVTPLEEEELSHYVIRKFCIEIANsdvESPAREIVQYHYTAWPDHGVPTHATS
|.||.|  |.   . .|.|.|... || .| .|||    .  ..| | |     ||.| || |.. .  ..   .  .| . |... .|.| ||. . ..
dlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk...kGetrsvkqfqlqswddmGvqkrpat

LLAFIRRIR---NSV---SRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQD
|..... .    . |   .. ..||.|||||||||||..| | ..|... .|  ||||||| . | .|  ||.|  |||.|..||.||  .|||.  |  
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvss

LHDRIKALQSRDPDSGETYIAKEFK
.. .. .|| |.| . .  | |||.
feaklsslqernpltqklniekefe

0040438 (Phosphotyrosine protein) phosphatases II 4-316 9e-102 335.8 In-house 2-312 (317) alignment
Range on Protein: 4-316
Range on HMM: 2-312/317.0
VNKLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDD
|..| ....  .  ... ..|||. ...    ........|||.|||| .|.  ||.|| .| |.|...||||||...||.|...|||||||| .||..|
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIAnsdVESPAREIVQYHYTAWPDHGVPTHATSLLAFI
|||||||.|...|||.|. .|.|. ||..|||. .. .||...|| |.||||.....|....|      .|. |.. ..|||.||||||| . ..||.|.
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl...gdsesrtvthfhytgWpdhgvppspdllldfl

RRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKALQSR
...|.. ... ||..||||||||||||.|... ||.|. ||| ||..  | . | ||...|||..||.|..|||.|  |...|   ...|. ... |.  
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllip

DPDSGETYIAKEFK
.. .. ... ||.|
lalddvklkekelk

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 6-94 1.9e-13 44.4 In-house 9-95 (95) alignment
Range on Protein: 6-94
Range on HMM: 9-95/95.0
KLAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISEldgIPGSDYINANFIDGYNHRNKFIATQG
 .  .    ||  .. | .||  |      ..     | | ||||. ||.  | |||...       |||||| |.|||  .| .||.||
vfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 7-286 6.6e-94 309.5 In-house 14-296 (298) alignment
Range on Protein: 7-286
Range on HMM: 14-296/298.0
LAEYCQIHHSTGNKSFKEEFMCIRTPGN----FSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFD
| .. .......   ...||  ...  .    .... . |.||| ||||..|.| |..|| ... |.   |||||| |...|..|| |||||.|. .|. 
lqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetve

DFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDvesPAREIVQYHYTAWPDHGVPTHATSLLAF
||||||.|.  ..|||.||..| .|.|..||||. . |.||.. |. |..|| . ...||. .. ....     ||..| |.| |||.|||..|||.|..
dFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee...kerevrqlhftsWpdkgvpenatsvldl

IRRIRNsVSRDAG--PIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTE
.|..|    ..||  |..|.|||||||.||.|..|..|... ||  ||.|  |   | .|  .||||.||.||..| .|| ...|.|
lrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 7-279 3.8e-87 287.0 In-house 2-275 (281) alignment
Range on Protein: 7-279
Range on HMM: 2-275/281.0
LAEYCQIHHSTGNKSFKEEFMCIRTPGNFSWDH-SLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFW
| . .. ...  |. |.||.  ..  |. .  . | ..||. ||||.|||| |.||| ... .    .|||||||..||.  ...||||||| .....||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN-PEEYGRLVVTPLEEEELSHYVIRKFCIEIANsdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIR
.||||.  | |||||. .| ||||| .|||  |   .|| ..|. ..||| ..|. ||| .|  .    ...||..| .||||||||||. .. || | .
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleres....getreveqlaytaWPdhGvPattkellefrk

RIRNSVSRDA-GPIVVHCSAGVGRTGTYIVLDAMLDQMSK-EGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
 ...  ...   |.|.||||||||||||| || ....... .  .|.   | . | .||.|||| .|| |.. |...|
evlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 7-342 8.6e-77 253.4 In-house 4-340 (515) alignment
Range on Protein: 7-342
Range on HMM: 4-340/515.0
LAEYCQIHHSTGNK-SFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFW
||..   .   ..   | |||  .  |  .    . .| | .||||.||.  | .|| .  ..  | |||.|| .| ...  . .||.|||   . ||||
laqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfW

RMVWEHGCSCIVMVTNIVERGKLKCQKYWPS--ANPEEYGRLVVTPLEEEELSHYVIRKFCIeIANSDvespAREIVQYHYTAWPDHGVPTHATSLLAFI
|.|...  . |.|||.  |  | || ||||   ..  ..| . |  .  |  .  ..||. . . ..|    .| . |.|.| |||.||| |..||| .|
rlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv.lkgdd....srtvtqfhfteWPdkGvpkhtssllkli

RRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKALQSR
. .. . .. . |...|||||||||| .| .| .. .. .  .||.| ||   | .|  .|||. || ||..|..|  .  ||   |  . | .. |.| 
kevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhss

DPDSGETYIAKEFKNL--DIGDSDVETFDSASMPENKSKNRF
    | . ..|||. |   . |  .    |.   .|. |||.
gdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknry

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 10-280 2.6e-92 304.0 In-house 11-279 (288) alignment
Range on Protein: 10-280
Range on HMM: 11-279/288.0
YCQIHHSTGNKSFKEEFMCI-RTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMV
. .. . .... |.||.  .     . | . . . .|..||||.||.. |..|| . .|.  .|.|||||..|||.....|.||||||. .| .|||..|
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WEHGCSCIVMVTNIVERGKLKCQKYWPSAN-PEEYGRLVVTPLEEEELSHYVIRKFCIEiansdVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIR
.|.  | |||.|..||.|| ||..|||.|. |..|| . || .|..|| ..| ||. .|      .   .|| ||.|.||||||||  .. ||...| . 
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.....kkkteleitqyqylaWpdhgvPeskapllellrqvk

NSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
.. . |.|||.||||||||||||.|.|||..|.. .|  .|..|.|.. | ||...|||. ||.||...|.. .
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_PTPN6_pd Subfamily PTPN6 11-278 4.8e-86 283.5 In-house 17-295 (306) alignment
Range on Protein: 11-278
Range on HMM: 17-295/306.0
CQIHHSTGNKSFKEEFMCI---RTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISeLDGIPGSDYINANFIDG--YNHRNKFIATQGPVSNTFDDFW
 . ..|.... |.|||  .    .   .| ... | ||| ||||.||.  ||||| ..  ...|||||||||.|..   ......||||| ...|  |||
ekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

RMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN-PEEYGRLVVTPLEEEELSHYVIRKFCIEIAnsDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIR
||||.  .  |||.|. ||||| || .|||...  ||||.. || ..|..|..|..|.. ..    . .. .||..|||...|||||||..   .|.|..
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk..kkkkeerevfqyhfksWPdhgvpkdpgavLdfle

RIRNSVSR----DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEG---AVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
 ...  ..    .|||||||||||.|||||.||.|..|....|.|    .||  .|  .| ||. .||||.|| |.. |. .
dvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

subfamily_PTPN9_pd Subfamily PTPN9 12-281 2.3e-80 264.8 In-house 8-291 (297) alignment
Range on Protein: 12-281
Range on HMM: 8-291/297.0
QIHHSTGNKSFKEEFMCIRT-PGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWE
.  ...|..  ..|.. ||  | .   ..| .  |  ||||....  |.||| ....|. . ||||||||.|||.... |||||||. .|..||||||||
ayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWe

HGCSCIVMVTNIVERGKLKCQKYWP--SANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANsdvESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRN
. .  |||.| .||||.|||..|||  . . .|.| | |. .| || ..|..|.. |. ..   ..  |... . ...|||.|||  |.||| ... .|.
qevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk...teesrkvthfqflsWPdyGvPssaaslldvlekvre

SVSR-------------DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAK
  .              .  |||||||||.|||||.| ||  |... ..| ||..  |.. | ||  ..||. || | . |..| |.
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal

0049772 (Phosphotyrosine protein) phosphatases II 13-284 3.5e-49 163.6 In-house 14-284 (314) alignment
Range on Protein: 13-284
Range on HMM: 14-284/314.0
IHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIVADHTRVAISELDgIPGSDYINANFIDGYnhrNKFIATQGPVSNTFDDF---------
|| .  .  ..  .  .........  . ...|. ||||..|.   .|| .. |. . |||||||...||.   .|||||||| ..|..||         
ihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpadnrvilpglp.vsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyn

-WRMV--WEHGCSCIVM---------------------VTNIVERGklkcqKYWPSANPEEYGrlvvtpleeeelshyvirkfcieianS----DvESPA
 ||||  ... .  |||                      ... ..|      ... |..|..                           .    . | . 
gwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk..........................eelydp.elfe

REIVQYHYTAWPDHGVPtHATSLLAFIRRIRNSvsRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKeGAVDIFGFVSHTRLqRN---MMVQTEAQYIFI
|....|... .||...|     ...|.. |..   .. ||..|||.||.|||||..|.. .. ..    . ... .|  .|   |    ....  ||.||
rlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefi

HDALMEAAKCGN
..||.|. |   
lealleylkflk

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 13-280 6e-45 148.3 In-house 15-287 (305) alignment
Range on Protein: 13-280
Range on HMM: 15-287/305.0
IHHSTGNKSFKEEFMCIRTPGNFSWDHSLKEE-NKPKNRYQNIV-ADHTRVAIselDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEH
     | . ...||....   .|   ...||  .. ||||...   |. || .   .|    .|| ||..      ..|| || |. .|  ||| | ...
rtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqd

GCSCIVMVTNIVERGKLKCQKYWPSANP-----EEYGRLVVTPLEEEELSHYV-IRKFCIEIANSDVESP---AREIVQYHYTAWPDHGVPTHATSLLAF
    | |. |..|.|  ||..|..| .      || |. ..  .|  .  ...   |  .. .   .| |   || . .||.  ||| |||.  ...| .
kveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel

IRRIRNSvsrdAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDI-FGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
. . | |     ||||||||||.||||. ..|. .|||.     ..     . . | |||  .||.|||.|.|. ...  
lekarps....kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

0047943 (Phosphotyrosine protein) phosphatases II 15-279 5.6e-92 303.3 In-house 7-271 (273) alignment
Range on Protein: 15-279
Range on HMM: 7-271/273.0
HSTGNKSFKEEFMCIRTPG-NFSWDHSLKEENKPKNRYQNIV-ADHTRVAIseldGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGC
...|.. ..|||  ..    .... ..|..||| ||||..|.  ||.|| .    | .|||||||...||||. .|||||||| .||..||||||||...
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

SCIVMVTNIVERGKLKCQKYWPSAN---PEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVespAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSV
..|||.|..||.|. || .|||. .   ...||.. || |.||. ..|..|.....  ...     |.. ..||| |||||||.. .||| ||. .|.  
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge...srtvthfhytgwpdhgvppslesllefielvrkal

SR--DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
.   . ||.|||||||||||||.|.|| .|||. ||| ||..  | . | || .||||. ||.|...||.| 
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0050432 (Phosphotyrosine protein) phosphatases II 16-285 6.7e-99 326.4 In-house 38-304 (308) alignment
Range on Protein: 16-285
Range on HMM: 38-304/308.0
STGNKSFKEEFMCIRTPG-NFSWDHSLKEENKPKNRYQNIVA-DHTRVAIseldGiPGSDYINANFIDGY--NHRNKFIATQGPVSNTFDDFWRMVWEHG
 .... ..|||. ..    .......|..|||.|||| .|.. ||.|| .    . .|||||||...|||  ....|||||||| .||..||||||||..
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

CSCIVMVTNIVERGKLKCQKYWPSA---NPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDvesPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNS
...|||.|..||.|. || .|||.    ...|||...|| |.||.|..|..|.....  ...   . |.. ..|||.|||||||.....||.|....|.|
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg...esrtvthfhytnWpdhgvPpspeilldflelvrks

VsrDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNT
   . ||||||||||||||||.|.|| .|.|. ||| ||.|. | . | ||..||||. ||.|...||.| .|.  |
l..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 16-294 5.6e-63 207.5 In-house 5-280 (283) alignment
Range on Protein: 16-294
Range on HMM: 5-280/283.0
STGNKSFKEEFMCIRTPGNfSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGipgsDYINANFID---GYNHRNKFIATQGPVSNTFDDFWRMVWEHG
...|| |.| .  .  |   . | .  .|||.|||.|.|| ||  || .  .      ||||| ||     |.. .|.|..|.|. .|  |||.||... 
vnnnklfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

CSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIAnSDVESPAReIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSR
 ..|||.|.. |  . || .|||.   |.|| . ||  .|     ..|... .    |  .|    .  | .  | . |  .   ||. | . | .    
itaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn.ssakstll.lahyqvidWleygeqaiinslvkfnkvislqtes

DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHD
  ||||||||.|.|||...| . | ....  |  ||.|  |   | || |.|||  || ..|.. .| | ||.|.    ||..
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 16-285 3.3e-61 201.6 In-house 11-298 (301) alignment
Range on Protein: 16-285
Range on HMM: 11-298/301.0
STGNKSFKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDG--IPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGC
.. ...|.|..  ...  . | . .|.||||. ||..||.  |. |. ...     .   .||||..||||....||||.|||. .|  ||||..|..  
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

SCIVMVTNIVERGKLKCQKYWPS--ANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDV------------ESPAREIVQYHYTAWPDHGV-PTHATS
. ||||||  |. | ||..|||.  |. ||.| . ||  .|  .  .|||.... | ..              .  .....|.. | ||..|| . ..| 
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNT
| .    |    . . ||.|||||..|.|.|.|. ..  |.|   || ||.|. .   | ..  .|.|  ||..|.|.. .  .. .|
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst

subfamily_PTPRK_pd Subfamily PTPRK 18-316 4.3e-98 323.0 In-house 20-313 (314) alignment
Range on Protein: 18-316
Range on HMM: 20-313/314.0
GNKSFKEEFMCIRTPgnfsWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIV
 .  ||||. ..       || . |.||. |||...|.| |..|| .  .|| | ||||||..||.|.. ..||.||||. .|  ||||.|....|..||
egygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv

MVTNIVERGKLKCQKYWPSANPEeYGRLVVTPLEEEELSHYVIRKFCIEIANSDVeSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPI
|.|..|| |..|| ||||      || . |. .| | |. .|.| | .| ..  . .  ||. |.....||||.||..||.||...||. .|   .||.|
mltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargq.eeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGri

VVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKALQSRDPDSGETYIAKEFK
||||||| |||||.|..| .|| . .|| ||.|  |   | ..  ||.|| ||.||.|...||. ||.|   | ...   .  .  ||..  . . .||.
vvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefq





0036941 (Phosphotyrosine protein) phosphatases II 19-292 6.2e-95 313.2 In-house 12-289 (297) alignment
Range on Protein: 19-292
Range on HMM: 12-289/297.0
NKSFKEEFMCI-RTPGNFSWDHSLKEENKPKNRYQNI-VADHTRVAIselDGiPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIV
.  ...||. . .   ..|....|..||..|||| .|   ||||| .   |. .|||||||...|||.. .|||||||| .||..||||||||.....||
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MVTNIVERGKLKCQKYWPSA--NPEEYGRLVVTPLEEEE--LSHYVIRKFCIEIANSDvesPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVS--
|.|. ||.|. ||..|||.   .. .||...|| |..|.  |..|..|.....  ...   . |.. ..||| |||||||....|||.||...|.  .  
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng...esrtvthfhytgwpdhgvpespaslldfielvrkvlkll

RDAGPIVVHCSAGVGRTGTYIVLDAMLDQMS---KEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDL
.. ||..|||||||||.||.|..| ||.|.    ||| |||. .| . | ||...|||. ||.|...||.|  |...| . ...|
psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 20-296 4.8e-77 254.3 In-house 20-295 (439) alignment
Range on Protein: 20-296
Range on HMM: 20-295/439.0
KSFKEEFMCIR-TPGNFSWDHSL--KEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCI
. |||.|  |  |  ... . ||  .| ...||||....| |||||.. |. |.| | |||||.|.||   . .||||||  .| |||||.|.|. .. |
eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

VMVTNIVERGKlkcqkYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIeIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSV-SRDAG
||.||.||  |     |||| .   || ..|    . || .|||| | . . . |     | ..|.||.||||. ||..|. .| |.| |  .  ... |
vmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkv.fnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeyg

PIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRI
|.||||||||||||| | ||  |.|.  |  ||| | |.  | ||. |||. .||.||..|..|  . |..   ..... ..
pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkef

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 20-282 6.9e-72 236.8 In-house 5-270 (274) alignment
Range on Protein: 20-282
Range on HMM: 5-270/274.0
KSFKEEFMCIrtPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDG-IPGSDYINANFIDGYNHRNK-FIATQGPVSNTFDDFWRMVWEHGCSCIV
|....||. .  | ||. ..     .. ||||..|.  ...|| ... ..  . |.|||||.| ||....| ..|||||..|| .|||||.... .. ||
kdlekeflel..PlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MVTNIVERGKLKCQKYWPSANP----EEYGRLVVTPLEEEELSHYVIRKFCIEIANSdvespAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRD
|.|.. |. . ||..|.| |.     |.|| . ..  .  |  .| .||. .. ...      |... | ||.|||| .| .|..|| ... ...| ...
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.....ersvkhywytdWPdhksPddantlldlvleveesreee

---AGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKC
   ..|.|||||||.|||| .|  .  . |. .|. ||... |.. ||.|  ||||. || .|| ||.. .|.
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 20-278 1.4e-48 160.5 In-house 16-275 (307) alignment
Range on Protein: 20-278
Range on HMM: 16-275/307.0
KSFKEEFMCI--RTPGNFSWDhsLKEENKPKNRYQNIVA-DHTRVaISELDGIpGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIV
.....||  .  .||   . .    . |  |||||.. . |..|. . ..||.  |||| ||..    . .|||..|||  ||  .|| |. ..   ...
qalvdefrvlakktpegvtve..afsantdknryqdvkcqdkgri.vvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvi

MVTNIVERGKLKCQKYWPSANPEE--YGRLVVT-PLEEEELSHYVIRKFCIEIANSDVE--SPAREIVQYHYTAWPDHGVPTHATSLLAFIrrirNSVSR
|. ...| .|.||..|||  . ..  .|    |  ...    .    . .|.... .|.  . .| | .. .. |||.|||    . . ..    ..|  
mlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll....eavry

DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSK-EGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|  |.||||||||||.|| . .  . |.| . .   |.  .|   | ||.  .||||||...|  |.|
dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

subfamily_ptpA1_pd Subfamily ptpA1 20-239 2e-44 147.0 In-house 21-255 (418) alignment
Range on Protein: 20-239
Range on HMM: 21-255/418.0
KSFKEEFMCIRT-PGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYnHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVM
.  ||||  .    |        |. |  |||| ||.  .|||| . ...   ||||||||.|||  . ..||.||||. ||  ||||||||  |  |||
hkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivm

VTNIVERGKLKCQKYWPSANPEE----YG--RLVVTP--LEEEELSHYVIRKFCIEIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNS-
..   |  ..||..|||     |    ||    |.    .|  |. .   |.         .|  .|.| ||.|  |||| .| |.  .  ... | |  
lsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrq

--V---SRDAGPIVVHCSAGVGRTGTYIVLDAMLDQ
  .   |    ||.||||||||||||.     |. .
nqiipssdrnvpiivhcsagvgrtgtfctavimmkk

subfamily_PTPN1_pd Subfamily PTPN1 21-295 9.7e-65 213.1 In-house 7-286 (290) alignment
Range on Protein: 21-295
Range on HMM: 7-286/290.0
SFKEEFMCIRTP-GNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGipgsDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMV
..|| .. ||    .|.  .. ..||...|||...   ||.|. . . |     |||||....  . . ..| ||||..|| | ||.||||. . ..||.
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml

TNIVERGKLKCQKYWPSANPE-----EYGRLVVTPLEEEELSHYVIRKFCIEIANSdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNS--VSR
 ..||....||..|||. . |     |  .| |. ..||. |.|..|.. .|  ..     .|||...|||.||| |||   ...| |. ..|.|  .|.
nkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlkt...qetreilhfhyttwpdfgvpespaaflkflfkvresGslss

DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGA---VDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDR
| || |.|||||.||.||....|..| .. |..    |||   . . | .|  ..||  |  | . |..| ||. ...  ||. . .
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqkrwke

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 21-281 1.1e-48 160.5 In-house 7-260 (267) alignment
Range on Protein: 21-281
Range on HMM: 7-260/267.0
SFKEEFMCIRTPGNFSWD--HSLKEENKPKNRYQNI-VADHTRVAISELDgipgSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVM
....||  |.   . |     |. |.|. .||...    |.||| ... .     .|||| ...||. .|.||.||.|..||  ||. .. ..... ||.
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl

VTNIVErGKLkcQKYWPSA--NPEEYGRLVVTPLEEEELSHYVIRKFCIEIANsdvESpAREIVQYHYTAWPDHgvpTHATSLLA--FIRRIRNSVSRDA
.|.. . ...  ...||    . ..|  |.|    |.|   | |  . ... |   || |.... |.|  |      |     |   |    .| .    
ltkvft.dni..rlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn...es.ahnvtlyyykkwnin...tnnkpylkplfgilaknqlengn

GPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAK
 |.||.||.||||.||..|.|..|... .|| .||| |. . | ||  .|.|  .||.||. | | |.
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae

0045098 (Phosphotyrosine protein) phosphatases II 22-284 1.5e-86 285.5 In-house 10-276 (278) alignment
Range on Protein: 22-284
Range on HMM: 10-276/278.0
FKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNI-VADHTRVAiseldgipgsDYINANFIDGYnhRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTN
. | .  .... . .. ..|...|..|||| .|   ||.||           |||||..||||  ..||||||||  .|..|||||.||.|...|||.|.
llefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

IVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSD-VESPAREIVQYHYTAWPDHGVPTHA--TSLLAFIRRIRNSVSR------
 ||.|. || .|||. ....||...|| |.||.|..|..|.. ..  ..   . . |.. ..||. |||||||..   .|.| ....||. ...      
lvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------DAGPIVVHCSAGVGRTGTYIVLDAMLDQMskEGAVDIFGFVSHTRLQRNM-MVQTEAQYIFIHDALMEAAKCGN
       . ||..||||||||||||..... ||...  || ||..  |.. | ||.. .||.. ||.|....|.|  ..|.
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk

subfamily_CG7180_pd Subfamily CG7180 22-284 5.6e-66 217.2 In-house 19-294 (296) alignment
Range on Protein: 22-284
Range on HMM: 19-294/296.0
FKEEFMCIRTPGNFSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTN
.| |.  . .  .    . |..||. |||. ..|  |..|| ...|||   |||||| ..|.. . ...| |..|. .| |.|||.|.....|..|..|.
yklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk

IVERGKlKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIA-------NSDVESPAREIVQYHYTAWPD-HGVPTHATSLLAFIRRIRNSVSRD
  .  | ....|||    |.|| ..|  .||..... .||.| .          . .|. . | . ....| |.  . ||  ...|. ..||.|  . . 
tfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv

-----AGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGN
      ||.||..| |..|.| |. .|| |....||. ||.|..|   | .|. .|..  .| .| | | ||  |. 
dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

0046845 (Phosphotyrosine protein) phosphatases II 23-287 9.9e-96 315.7 In-house 3-281 (284) alignment
Range on Protein: 23-287
Range on HMM: 3-281/284.0
KEEFMCIRTPGN---FSWDHSLKEENKPKNRYQNIV-ADHTRVAISELDG-IPGSDYINANFIDGY-----NHRNKFIATQGPVSNTFDDFWRMVWEHGC
.|||. ..       .|....|..||. ||||..|.  ||.|| .. ||| ...||||||...|||     ....||||||||..||..||||||||...
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

SCIVMVTNIVERGKLKCQKYWPSAN-PEEYGRLVVTPLEEEELSHYVIRKFCIEIAnsDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVS-
..|||.|..||.|. || .|||. . . .||.. || |.||. ..|..|.....    ..... |.. ..|||.|||||||.....||.|.| .|.. . 
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-RDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEG---AVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEF
  . ||||||||||||||||.|.|| .|.|. |||    ||... |.. | ||..||||..||.|...||.|..|...| .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 25-117 6.2e-09 29.8 In-house 19-115 (347) alignment
Range on Protein: 25-117
Range on HMM: 19-115/347.0
EFMCIRTPGNFSWDHSLKeeNKPKNRYQNI-VADHTRVAISELDG-----IPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVM
| ..  .| .|.     |  .  ||| ..  . | ||| .|  .       .   ||||  |   | ....| || |. .|  |||.||     . .| 
enlanyspskftsvewek..slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 25-124 5e-06 19.5 In-house 10-80 (169) alignment
Range on Protein: 25-124
Range on HMM: 10-80/169.0
EFMCIRTPGNFSWDHSLkeeNKPKNRYQ-NIVADHTRVAISELDGIPGSDYINAnfidgynhrnkfiatqgpvsntfddfwRMVWEHGCSCIVMVTNIVE
||| .    ||  . .    |. |||    .   |||| .  .    |||||||                           ||.||   | ||.. .  .
efmktieynnfmaeltc...netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtdd

R
.
k

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 25-124 6.8e-06 19.0 In-house 9-79 (169) alignment
Range on Protein: 25-124
Range on HMM: 9-79/169.0
EFMCIRTPGNFSWDHSLkeeNKPKNRYQ-NIVADHTRVAISELDGIPGSDYINAnfidgynhrnkfiatqgpvsntfddfwRMVWEHGCSCIVMVTNIVE
||| .    ||  . .    |. |||    .   |||| .  .    |||||||                           ||.||   | ||.. .  .
efmktieynnfmaeltc...netknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtdd

R
.
k

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 26-201 4e-34 112.8 In-house 16-189 (297) alignment
Range on Protein: 26-201
Range on HMM: 16-189/297.0
FMCIRTPGNFSwdHSLKEENKPKNRYQNIVA-DHTRVAIseLDGIPGSDYINANFIDGY--NHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIV
..  . ...||   . ..    ||||..|.| | ||| .  | .|...|||||...     ..  |.| .|||.|.| ||||..|.|..   ||||... 
lldeargesfs..sakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklq

ERGKLKCQKYWPSANPEE--YGRLVVTPLEEEELShYViRKFCIEIANSDVeSPAREIVQYHYTAWPDHGVPTHATSLLAF
| |. ||  ||||.. |    | .||  | .     .  | .  |.      |  | .    . .|||||||.    |  |
edGrdkcapywpsvvqerlkagdvvveflsstsde.fd.rviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrf

subfamily_PTPN12_pd Subfamily PTPN12 27-279 1.6e-79 261.8 In-house 22-276 (290) alignment
Range on Protein: 27-279
Range on HMM: 22-276/290.0
MCIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERG
   ..   .| ... ||||. ||||..|.  |..|| .|. .. .|||||||||| | . . ..||.|||...| ||||||.||.  . .||. ..|| |
ekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelg

KLKCQKYWPSA--NPEEYGRLVVTPLEEEELS-HYVIRKFCIEIAnsdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSA
| ||..|||.   .. |.| . ||  ||. ..  ..|| . .|       .  |.. |.|||||||||||. |.|||..|. .|.  .... |.||||||
kkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsa

GVGRTGTYIVLDAMLDQMSKEGA---VDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
||||||| |..| . ... .|     .|.|  | . | ||. .|||. || ... |..| 
GvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

DSPc_SM00195 28-280 6e-90 296.5 In-house 8-262 (263) alignment
Range on Protein: 28-280
Range on HMM: 8-262/263.0
CIRTPG-NFSWDHSLKEENKPKNRYQNI-VADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERG
 ...   . . ... |..|| ||||.|| . ||||| ... .. .||||||||.|.|.|...|.|||||| ..|..||||||||.....|||.|. .|.|
kleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng

KLKCQKYWPSA--NPEEYGRLVVTPLEEEELS-HYVIRKFCIEIANSdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSA
| ||..|||.   ..|..|.. |.  |.|. . ....|.. ..  .    . .|.. ||.|..||||||| ...|.|...| ...| |.  |||||||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
|||||||....| .|.....|  ||||  |.. | || .||||..||.||..|..|..
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 28-280 6e-90 296.5 In-house 8-262 (263) alignment
Range on Protein: 28-280
Range on HMM: 8-262/263.0
CIRTPG-NFSWDHSLKEENKPKNRYQNI-VADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERG
 ...   . . ... |..|| ||||.|| . ||||| ... .. .||||||||.|.|.|...|.|||||| ..|..||||||||.....|||.|. .|.|
kleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng

KLKCQKYWPSA--NPEEYGRLVVTPLEEEELS-HYVIRKFCIEIANSdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSA
| ||..|||.   ..|..|.. |.  |.|. . ....|.. ..  .    . .|.. ||.|..||||||| ...|.|...| ...| |.  |||||||||
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
|||||||....| .|.....|  ||||  |.. | || .||||..||.||..|..|..
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 28-297 4.9e-86 283.9 In-house 44-308 (319) alignment
Range on Protein: 28-297
Range on HMM: 44-308/319.0
CIRTPGNFSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTnivergK
| ...     ...  ..|| |||. ||.| |...| .  |.|. .|||||| |..|| ...|.||.|||  || .|||||.||. || ||..|      |
cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......k

LKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFciEIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRD--AGPIVVHCSAGV
 || .|||    ....|  |     || . ||.|..  |...   |   |.| |.|.  |||.||| ... |. .....|   |.     .|||||||||
dkcsqywplkivikeerfkvkvdsveetaeyvvrdi..elsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGv

GRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIK
||||.|||||..||.| .|  ||.. ||   | ||| .||  .|| ||. ||.|    |...  . |.   ..
GrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 35-296 1.2e-84 279.2 In-house 15-271 (284) alignment
Range on Protein: 35-296
Range on HMM: 15-271/284.0
FSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTnivergKLKCQKYW
    ..  ..|| |||. .|.| |...| .  |.|. .|||||| || || ...|.||||||  || .|||||.||. || ||..|      | || .||
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PSANPEEYGRLVVTPLEEEELSHYVIRKFciEIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRD--AGPIVVHCSAGVGRTGTYI
|    ....|  |     || . ||.|..  |...   |   |.| |.|.  |||.||| ... |.......|   |.     .|||||||||||||.||
plkivikeerfkvkvdsveeseeyvvrdi..elsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

VLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRI
|||..||.| .|  ||.. ||   | ||| .||  .|| ||. ||.|    |...  . |.   .
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayl

subfamily_PTPN3_pd Subfamily PTPN3 35-280 5.8e-73 240.2 In-house 31-275 (280) alignment
Range on Protein: 35-280
Range on HMM: 31-275/280.0
FSWDHSLKEENKPKNRYQNIVA-DHTRVAISELDgipGsDYINANFI----DGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKC
 . ... | || .||||..|.. |.||| ..| .     ||||||..    .. .  |..||||||...|  |||.||||. .| |||.|..||||. ||
laisaarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

QKYWPSAN-PEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDvesPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTG
 .|||. .   |||.. |.  .|.| . ||.|..... ....     |.|.|  |.||||||||......| |..|.|.  | .  |.|||||||.||||
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketk...eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtG

TYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
 .|.|.  |  . .. .| .   |.. | || |.|||..|| |. .|.... 
vlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_egg_pd Subfamily egg 35-276 3e-32 106.5 In-house 30-266 (307) alignment
Range on Protein: 35-276
Range on HMM: 30-266/307.0
FSWDHSLKEENKPKNRYQNI-VADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERgkLKCQKYW
 |  ......|. | | . .  .| .||..    |    |.| || ..|    |.|| .| |. || |||||||..  .  |||.|  .|    .|. ||
islttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PSANpEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVESPAREIVQYHYTAWpDHGVPTHATSLLAFIRRIRNSvSRdagPIVVHCSAGVGRTGTYIVL
| |. ..  ..|   |. | |  .        ...  .  . .|     .  . |    ..  | |  .|..||  |.   |.||..  || ...| . .
pkae.sdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrnl.sk...pvvvqdilGvskaatlvai

DAMLDQMSKEGA--VDIFGFVSHTRLQRNMMVQTEAQYIFIHDAL
.  | .. .       .   |   ||.|.. |..  .|.|..  .
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv

0040439 (Phosphotyrosine protein) phosphatases II 36-279 1.3e-86 285.5 In-house 2-245 (249) alignment
Range on Protein: 36-279
Range on HMM: 2-245/249.0
SWDHSLKEENKPKNRYQN-IVADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWP
.....|..|||.||||.. .  ||.|| .| |.| ..||||||..||||.. ..||||||| ..|..|||||.||.|...|||.|. ||.|. ||..|||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SANPEEYGRLVVTPLEEEELSHYVIRKFCIEIAnsdVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSR--DAGPIVVHCSAGVGRTGTYIV
. .. |||...|| |..|....|..|.....      ... |.. ...|| ||||||| .  .||.||...|. ...  . ||..||||||||||||.|.
lggsleygdftvtllsvevkddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

LDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
.. ||.|. ||. ||..  |.. | ||...||.. ||.|...||.| 
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 36-280 3.5e-48 158.7 In-house 45-283 (290) alignment
Range on Protein: 36-280
Range on HMM: 45-283/290.0
SWDHSLKEENK--PKNRYQNIV-ADHTRVAISelDGIPGsDYINANFIDGYNhrNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKY
  . .. ..|    ||||...|  | ||| ..  || .| ||. ||...| .    || |||.. .|  |.|||| ... . |||. ...| || ||..|
ylerkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPSANPE--EYGRLVVTPLEEEELSHYVIRKFcIEIANSDVeSPAREIVQYHYTAWPDHGVPThatSLLAFIRRIRnSVSRDAGPIVVHCSAGVGRTGTY
.|  . |   .| . |.  ||..    .|.|  . . . |       .  ..  .|||. |.    | ||..| .| .. . .||.|||||||.|||||.
ypekeGevltfGeitvlcseeddkdaniikkt.lsvrdkds.Gkehklkhlkikswpdksval...stlallrtlr.ilrkasGpvvvhcsaGiGrtGtf

IVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
. ... |. . .  ..|. . |   |  |   || . ||. . ..|..  
vaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG

0037934 (Phosphotyrosine protein) phosphatases II 37-278 6e-80 263.5 In-house 2-240 (243) alignment
Range on Protein: 37-278
Range on HMM: 2-240/243.0
WDHSLKEENKPKNRYQNIV-ADHTRVAIseldgiPGSDYINANFIDGYNhrnKFIATQGPVSNTFDD----FWRMVWEHGCSCIVMVTNIVERGKLKCQK
. ..|..||..||||..|.  ||.|| .      .||||||||.|....   ..|||||| ..|..|    ||||.||.|...|||.|. ||.|..|| .
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPsaNPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVESpaREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNS--------VSRDAGPIVVHCSAG
|||  ....||...|| |.||.|..|..|....|  . | ..  |....|||..|||||||.. ..||.|.. .|.         .  . ||..||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddlt..rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTYIVLDAMLDQMskeGaVDIFGFVSHTRLQRNM-MVQTEAQYIFIHDALME
||||||.|... ||...   | ||..  | . | ||.. .|||. ||.|...||.|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPRN_pd Subfamily PTPRN 37-278 5.6e-59 194.3 In-house 48-290 (297) alignment
Range on Protein: 37-278
Range on HMM: 48-290/297.0
WDHSLKEENKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNHRN-KFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWP
 . . .|.|  |||.....  ||.|| ..|      |||||| .|   . |.  .||||||...|  |||.||||.|.  ||..|.. | |  .|..|||
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

SANPEEYGRLVVTPLEEEELS-HYVIRKFCIEIANsdvESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVL
    | |.   |  . |   .  |..| | .   .    | .| . |.|. .||..|||. | ||| | |..  |    . |||||||.|.||||.||..
deGsevyhiyevhlvsehiwcddylvrsfylknlq...tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyili

DAMLDQMSKE-GAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
| .|... |    .||   . | | ||. .|.|..|. |.  |. |
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

0042113 (Phosphotyrosine protein) phosphatases II 38-278 1.8e-85 281.5 In-house 2-241 (245) alignment
Range on Protein: 38-278
Range on HMM: 2-241/245.0
DHSLKEENKPKNRYQNI-VADHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA
...|..|||.|||| .|   ||||| .|. .| ..||||||...|||.. .|||||||| ..|..|||||.||.|...|||.|. .|.|. ||..|||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

NPEEYGRLVVTPLEEEELSHYVIRKFCIEIansDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVS-RDAGPIVVHCSAGVGRTGTYIVLDA
.. .||...|| |.|| |..|..|.....    . ... ||...|||. |||||||..  .|| |....|. ..  . ||..||||||||||||.|... 
esltygdftvtllseehlddytvrtlevtn...lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

MLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
||.|. ||. |...  | . | || ..|||. ||.|...||.|
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_PTPN14_pd Subfamily PTPN14 38-278 1.4e-52 173.5 In-house 42-294 (300) alignment
Range on Protein: 38-278
Range on HMM: 42-294/300.0
DHSLKEENKPKNRYQNIVA-DHTRVAISELDGIpGSDYINANFIDGY--NHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWP
. .  .||..|||.....  ...|| .|       ..||||  |      .. ..|..|||. .|  |||.||||.| . |||.|.. | || |. ||.|
staklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

SA----NPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVEspaREIVQYHYTAWPDHGVPTHATSLLAFIRRIR---NSVSR------DAGPIVVHCS
.     .  |.|.  ||    |. . .. ... ..   |  |   |...   || |||||||   .. | ......   . ...         |..||||
kleskkktvefgkfkvttkfsedsdsvittglklkhlpskee...rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

AGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|||||||  |. | ..  . ..  .||   ... | || ..||| ||| |....|..
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 39-191 2.2e-13 44.4 In-house 90-235 (244) alignment
Range on Protein: 39-191
Range on HMM: 90-235/244.0
HSLKEENKPKNRYQ-NIVADHTRVAISEldGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERgklkcQKYWPSAN
 ... .|  |||    .  |  || .|.  |  |  |||| |.       ..| || |...|  |||.|. |     .|..  . |      ..||| ..
dafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse

PEEYGR--LVVTPLEEEELSHyvIRKFCIEIaNSDVESPAREIVQYHYTAWPDHGV
| |.    . ||  . .|.    |.   .|| .||..   . .  .  . ||  | 
plewyeeditvtltdrdefkn..ikasnlei.esdmneshqaltmfqisnwpsdgt

subfamily_PTPN13_pd Subfamily PTPN13 40-279 6.8e-69 227.2 In-house 32-268 (273) alignment
Range on Protein: 40-279
Range on HMM: 32-268/273.0
SLKEENKPKNRYQNIV-ADHTRVAISELDGipgsdYINANFIDGYN--HRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA
. |.||| ||||.|..  |.||| ...  |     ||||..|      .. ..||.|||. .| .|||.||||  .. |.|||. .|.||.||..|||. 
gkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

NPEE---YGRLVVTPLEEEELSHYVIRKFCIEIANSdveSPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNsVSRDAGPIVVHCSAGVGRTGTYIVL
. ..   ..|| |. |. ..|. .|.|.. ..  .|   . .||... ....|||||||..|..|| |....|. . .||||||||||||.||.||.|..
knkklkvsnrlevellkvqkldgfvvralavkdses...gesrevahlnfvkwPdhgvPssaaellqfvaevrr.lqtdagPivvhcsaGiGrsGtliti

DAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
|..|. ....  .|.   | . | ||. .|||. ||||.. |..|.
dvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 42-289 3.8e-84 276.8 In-house 6-245 (250) alignment
Range on Protein: 42-289
Range on HMM: 6-245/250.0
KEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLkCQKYWPSANPEE
| .|| |||| .|.| |..|| . . .|   |||||| |..||. |. |||||||...|. ||||||.|.  . |||.||..| .|  ...|||  ..|.
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek

YGRLVVTPLEEEELSHYVIRKFCIEianSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSR-DAGPIVVHCSAGVGRTGTYIVLDAMLDQ
|| . |..|..|| . |..||. .    .  ..  | ..|.|...||| ||| .||. |....... |  . ...|..|.|||||||.|..|..||.|..
yGdvtvsllskeefadytkrklkls...kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCgntefkV
. ||  ||.| ..   | .|  .|....||.|.. ....| ..      |
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds......v

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 42-279 6.2e-67 220.2 In-house 4-239 (239) alignment
Range on Protein: 42-279
Range on HMM: 4-239/239.0
KEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNK-FIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANpE
|  || |||| |||. ||.|| . .|   | ||||||...  |.   | .||||| |. .  |||||.|.     |||.| ..|  | ||..||| .   
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.s

EYGRLVVTPLEEEELSHYVIRKFCIEIANsdvESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQ
.|  | ||  . | .. |.|| | .       ..  | . |||.| |||.||| .||..| . |.| .     | | |.||||||||||...|.|||| |
kycnlrvtlrktevfadyiirtfvmsqvg...qteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
  |. .|||| .|   | .|  ||||  ||.||| |..||
akkqktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 42-278 1.9e-66 218.7 In-house 5-239 (239) alignment
Range on Protein: 42-278
Range on HMM: 5-239/239.0
KEENKPKNRYQNIVA-DHTRVAISELDGIPGSDYINANFIDGYNHRNK-FIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANpE
|  || |||| |||. ||.|| . .|   | ||||||...  |.   | .||||| |. .  |||||.|.     |||.| ..|  | ||..||| .   
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst.s

EYGRLVVTPLEEEELSHYVIRKFCIEIANsdvESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQ
.|  | ||  . | .. |.|| | .       ..  | . |||.| |||.||| .||..| . |.| .     | | |.||||||||||...|.|||| |
kycnlrvtlrktevfadyiirtfvmsqvg...qteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
  |. .|||| .|   | .|  ||||  ||.||| |..|
akkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_PTPN23_pd Subfamily PTPN23 43-281 1.8e-56 186.1 In-house 41-281 (288) alignment
Range on Protein: 43-281
Range on HMM: 41-281/288.0
EENKPKNRYQNIV-ADHTRVAISeldgIPGSDYINANFIDGYNH-RNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA--NP
. .  |||...|.  ||.|| .         ||||| |. .      .|||||.|  .|  |||.||.|   | |||...  |.|| |...|||..  ..
klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

EEYGRLVVTPLEEEELSHYVIRKFCIEIANSDVespAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRN---SVSR-DAGPIVVHCSAGVGRTGTYIVLD
...| | ||  ...|....| |.. .|. ..|     ....  ..|.||..|||    .||.|.  ...   .| |    |.||||||||||||.. .. 
vkfgdlsvtlksvretethvervlkletldada...vksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvy

AMLDQ-MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAK
| . .   ..| .||   ||. | ||  |||...|. |  .| .|||.
aavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 43-278 6.9e-36 118.3 In-house 35-267 (281) alignment
Range on Protein: 43-278
Range on HMM: 35-267/281.0
EENKPKNRYQNIV-ADHTRVAISE-LDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANpee
  |. |||| ||   | .|| .   .     .||| ||.|     .  .| ||||  .|  |||||.|.   ..|||. ...|  . || .|.|      
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna...

YGRLVVTPLEEEELSHYVIRKFCIEIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNsvsRdAGPIVVHCSAGVGRTGTYIVLDAMLDQM
.  | .  |  .     | . .     |   |  .| | .. .  |||  ||  .  .|  .|.||    | . | |.||||||||.|| . ..  |. .
hcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira...r.stppvihcsagvgrsgtlmaveialqsi

SKE-GAVDIFGFVSHTRLQ-RNMMVQTEAQYIFIHDALME
       ||   ||| |.  |   |||  ||..|   |..
hshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 43-279 2.1e-28 94.1 In-house 33-269 (285) alignment
Range on Protein: 43-279
Range on HMM: 33-269/285.0
EENKPKNRYQNIV-ADHTRVAISELDgipgSDYINANFIDGY-NHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE-
| |   ||| ..   . ||| . . |     ||| |...    . .. .|.||||. .|. |||.|...   . ..|.  ..| |  ||  |.|    | 
eanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

-EYGRLVVT--PLEEEELSHYVIRKFCIeIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNsVSRDAGPIVVHCSAGVGRTGTYIVLDAM
 ..|.  .|    .|| ..  ..  . . |   |  |    . . .   |||.  |  |  .. . . ... |     ||.|||||||||| |.. .|  
vkfgkyeitlteckeeaiagtilnaltv.intedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidya

LDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
  .. ..  ....  |   |  |   ||.  |..|..  ||| 
tirimenpniemldivremramrfqavqshmqflflyvvlmey

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 44-278 7.6e-70 229.8 In-house 2-237 (237) alignment
Range on Protein: 44-278
Range on HMM: 2-237/237.0
ENKPKNRYQNIVA-DHTRVAISELDGipGSDYINANFIDGYNHR-NKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN-PEE
||| |||| |||| ||.|| .    .  |||||||....|..   .|.||.|||. .. ||||.|||.  || |||.| ..|. .||| |||||.. |. 
enkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGRLVVTPLEEEELSHYVIRKFCIEIANSDVesPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSR--DAGPIVVHCSAGVGRTGTYIVLDAMLD
|| | |.   .||.| | .| . .    .      | | ||..|.|||.||| ....|| | ..| |      ..|| ..|||||||||| ..|.|||| 
ygvltvslkkkeefsdytvrslllskrltlk..evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|  ..  |||. .|     .|  ..||. ||.|||....|
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 44-277 5.5e-41 135.2 In-house 54-286 (305) alignment
Range on Protein: 44-277
Range on HMM: 54-286/305.0
ENKPKNRYQNIVADHTrvAISELDGIPGSDYINANFIDGYN-HRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYG
 .. |||||.. ..    ..  ||  . |||| ||..       ..||..|||. .| |.|| || ..    |||. . || ||||| .||| |. |   
iaitknryqdvpcqdq..savkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

RLVVTPLEEEELSHYVIRKFCIEIANSDVES---PAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSvsrdAGPIVVHCSAGVGRTGTYIVLDAMLDQ
      .|.   |. . |   |.|.  ..         . . ..| ||| |||    . | ..  || |      |||||||||.||||| . .. .|..
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs....kvpivvhcsagigrtgtivaieyilek

MSKEGAV-DIFGFVSHTRLQRNMMVQTEAQYIFIHDALM
....  .  .  .|   | || . .|.. ||.|||  ..
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvml

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 44-285 1e-36 121.1 In-house 51-294 (310) alignment
Range on Protein: 44-285
Range on HMM: 51-294/310.0
ENKPKNRYQNIVA-DHTRVAIsELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN-PEEY
..  |||| ..|  | .|| . ..|     ||| ||..     |. || .|||.  |  |||||...  .  |... ...| |. ||  ||||    | |
kymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtety

GRLVVTPLEEEElSHYVIRKFCIEIANSDV---ESPAR----EIVQYHYTAWPDHGVPTHATSllAFIRRIRNSVSrdAGPIVVHCSAGVGRTGTYIVLD
| . || | |     . | .... .   .|   | ||      .   ..  ||| |||       .  .|.   |    || |||||||..|... . |.
gcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch..tvpqrllaqvr..hgpcvvhcsagkdrlyvvvalk

AMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKcGNT
  .|.. .   ||.   ... . .| . .||| ||..|.   .  |. |.|
lkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar.get

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 44-298 4.7e-18 60.3 In-house 18-277 (290) alignment
Range on Protein: 44-298
Range on HMM: 18-277/290.0
ENKPKNRYQNIVADHTRVAISELDGIPGSDYINANFIDgYNHRNKFIATQGPVSNT-------FDDFWRMVWEHGCSCIVMVTNIVERGKL----KCQKY
... ..|... .. .|||.. .      .||| ||..  . .  ..|.|| |  ..         .|| |. .     .||. .  |. .      |.||
khemdqRlevpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WPSANPEE--YGRLVVTPLEEEELSHYVIRKFCIEIANSdvesPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSvsrdAGPIVVHCSAGVGRTGTY
 | .  ||  .. | |   . |.     .|. ...  .         .  . .  | .  |. .  .||. |. ...|      |..|||  |. |  . 
vpesvgeelkfkgltvkCkskekeddvetRelvvkfdde....eeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAal

IVLDAMLDQMS-KEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFKVQDLHDRIKA
  ..     .  ..|.| .   ..  | ||....... .. |.  ...  |.    .|  .. . ..||
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkaka

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 44-278 1e-17 58.7 In-house 46-277 (303) alignment
Range on Protein: 44-278
Range on HMM: 46-277/303.0
ENKPKNRYQNI-VADHTRVAISEldgipgSDYINANFIDgYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANP---E
.|  |||. .. . ||..| .|.      | || |....  . ..| | || |.| |  |||.|. |    |....    |  ||  .  .|  .     
knmdknrfvdvicldhskvklsd......ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

EYGRLVVTPLEEEELSHYVIRKfCIEIANSDVESparEIVQYHYTAWPDHGVPTH-ATSLLAFIRRIRNSVSR--DAGPIVVHCSAGVGRTGTYIVLD-A
|   . |  . . ||..    |  . ..| |  |    .  .|| |||   .|.. .  ..  | ...  . .  |. | |    .|.||.||. ... |
eersirvgefkrvelgdgwvlk.vlsvsngdyks...flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

MLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
 |   |.. ..|.   .   |  |   ||  .|. ...  | |
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae

Y_phosphatase Protein-tyrosine phosphatase 45-278 1.6e-83 275.1 Pfam-A 1-235 (235) alignment
Range on Protein: 45-278
Range on HMM: 1-235/235.0
NKPKNRYQNIV-ADHTRVAIselDGIPG-SDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWP--SANPEE
|| ||||..|. .|.||| .   .| .| |||||||...||.. .||||||||...|..|||||||.. ...|||.|. .|.|. ||..|||  . ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGRLVVTPL-EEE-ELSHYVIRKFCIEiaNSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLD
||.. |.   .|. . ..|..||. ..  ... ||  ||. |.|||.|||||||....||| .||....| . . ||.|||||||||||||...||..|.
ygdikvelkekekedekeytlrklelk..kkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|...|. ||.. .|.. | ||..|||...||||...|..|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 45-278 1.6e-83 275.1 In-house 1-235 (235) alignment
Range on Protein: 45-278
Range on HMM: 1-235/235.0
NKPKNRYQNIV-ADHTRVAIselDGIPG-SDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWP--SANPEE
|| ||||..|. .|.||| .   .| .| |||||||...||.. .||||||||...|..|||||||.. ...|||.|. .|.|. ||..|||  . ....
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGRLVVTPL-EEE-ELSHYVIRKFCIEiaNSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLD
||.. |.   .|. . ..|..||. ..  ... ||  ||. |.|||.|||||||....||| .||....| . . ||.|||||||||||||...||..|.
ygdikvelkekekedekeytlrklelk..kkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|...|. ||.. .|.. | ||..|||...||||...|..|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 45-280 1e-63 209.8 In-house 20-264 (270) alignment
Range on Protein: 45-280
Range on HMM: 20-264/270.0
NKPKNRYQNIVAD-HTRVAISELDGIPGSDYINANFIDGYNHR-NKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE---
.|  |||..|. . .||| ..||.  . . |||||.. |.... .|.||..||. .|  .||||.||.  ..|||.|...|.|. ||..|||. . |   
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-EYGRLVVTPLEEEELSHYVIRKFCIEiANSDvespAREIVQYHYTAWPDHGVPTHAT------SLLAFIRRIRNSVSRD--AGPIVVHCSAGVGRTGTY
 |.| . |. |.||  . |....  .|  ...     |..| ..|..|||||||...       .||. .| .|.| ..   |.|..|||||||||||| 
ledgkikvlalseekeegyiltrlrle.ekge....errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

IVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
|.|| ..  ..... ||.   ... | .|  .||.  || |.. |..| |
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

0041856 (Phosphotyrosine protein) phosphatases II 45-288 9.1e-56 183.6 In-house 1-179 (182) alignment
Range on Protein: 45-288
Range on HMM: 1-179/182.0
NKPKNRYQNIVADHTRVaiseldgipGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTnivergklkCQKYWPsanpeeygrl
|..||||..|.  .            ..||||||...|. . ..|||||||  .|. ||.||..|.|...||..|         .  |||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

vvtpleeeelshyvirkfcieiansdvESPAREIVQYHYTAWPDHGVPThATSLLAFIRRIRNsvsrDAGPIVVHCSAGVGRTGTYIVLDAMLDQmskeG
                           |   |...||.|. |||||||.   .||.||.....    . ||..||||||||||||..... |. .    |
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g

aVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCGNTEFK
 |...  |.. | .|..||.|. ||.|...||.|  ....|. |
.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 45-281 1.5e-54 179.7 In-house 38-278 (287) alignment
Range on Protein: 45-281
Range on HMM: 38-278/287.0
NKPKNRYQNIV-ADHTRVAISElDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA-NPEEYG
.  |||| ...  |.||| .|. .|  ||||||||.. .|.. ..|||.|||.. |  ||||.|.|.  . ....|  || ..||| ||||    |   |
avkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

RLVVTPLEEEELS-HYVIRKFCIeiANSDVESpAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNS--VS---RDAGPIVVHCSAGVGRTGTYIVLDAM
   |. |. . .. .| .| . .  .. . .  || . |... .|||....  | .|. |.  ...   ..    ..||.|||...|.||.|... . ..
GysvvlldydikePeygvralrl..idletre.arvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAK
.... . | ||.   | . | .|. .||.  |. .. .||.   |
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 45-278 6.5e-37 122.1 In-house 43-269 (288) alignment
Range on Protein: 45-278
Range on HMM: 43-269/288.0
NKPKNRYQNIV-ADHTRVAISelDGipGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEE--Y
|  ..||.|.   | ||| .|  |      ||.|| .   ......| .| |.  | . .|.|. | .   |||.....|.|| | ..|.||   |.  .
nptrdryenlprcditrvkls..dd..pdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GRLVVTPLEEEELSHYVIRKFCIEIanSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSvsrdAGPIVVHCSAGVGRTGTYIVLDAMLDQMS
|||     .. .  . ...   . |  | .   .  . . |.  |.|.|||    | | .. ....       |||||.||||||||| |.   .|... 
grlctvvkkkradidklvkvsllri..skegeekvivkilhlleWdddgvPenylsplrllevlksl....qkPivvhssaGvGrtgtlililialeslr

KEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
 .  . |  .... | .|   .||| ||...|  ..|
lddflgirsllaklreerfkaiqtemqylyvhrcvle

subfamily_CG42327_pd Subfamily CG42327 45-209 8.9e-29 95.1 In-house 28-194 (319) alignment
Range on Protein: 45-209
Range on HMM: 28-194/319.0
NKPKNRYQNIV-ADHTRVAISELDGIPGSDYINANFIDGYNH-RNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSA----NP
 |.|.|. |.|   .|||   .    . . |..|... ||.  .| .||.| .  ..  ||||.|||     || .|.. | |  .| .|.|.     | 
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

EEYGRLVVTPLEEEELSHYVIRKFCIEiaNSDvESPAREIVQYHYtAWPDHGVPTHATSLLAFIRRIRNSV
. || . ||  . |   .|.|  . .   . | .. .||.  | |  |.. .||.. ..|.| . ..|.|.
slyGdilvtlkgrevkdryaistlllk..rvd.keesrelthywy.kwleaevPaeeaaliamllevrssl

subfamily_eak_pd Subfamily eak 45-203 1.5e-09 31.7 In-house 52-205 (332) alignment
Range on Protein: 45-203
Range on HMM: 52-205/332.0
NKPKNRYQNIVADHTRVAISELDGiPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE--EYG
.  .| .. .  |.  | ..         ||||  ..  .  .|.| |  .  .    ||.|| |    .||.. . || .  | .||.|    |  ..|
avnrnvvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfG

RLVVTPLEEEELSHYVIRKFCIEIANSdvespAREIVQYHYTAWPDHGVPTHaTSLLAFIR
 | |.  |  . . .  |.. ..  |      . ..  |..  | .  .|     .||. .
ildverkefvkrniletrllelskGne.....thrvlhykvfGwtettlpky.edflalrk

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 46-272 5.8e-38 125.3 In-house 51-273 (301) alignment
Range on Protein: 46-272
Range on HMM: 51-273/301.0
KPKNRYQNIVADhTRVAISEL---DGIPgsdyINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEE--
| |.||...  .    |.  .     .|    | ||.|.   | ..|||||||..|| .||| |.  .    |||... ||. . ||..| |.  .|.  
kdkhryptvPck.PstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

YGRLVVTPLEEEELSHYVIRKFCIEIANSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSvsrdAGPIVVHCSAGVGRTGTYIVLDAMLDQM
 ||  ..  ..| . .  | |  .|...|  . ..| .. | |. |.|.|||   . |  ..  ...|      |||||||||.||. ..|  . .  ..
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteylarev

SKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFI
  .  ...   . | | .|   |||. |  ..
eadptieltealkhlrehrwngvqtnsqlywm

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 46-279 1.5e-28 94.4 In-house 44-275 (312) alignment
Range on Protein: 46-279
Range on HMM: 44-275/312.0
KPKNRYQNIV-ADHTRVAISELDgipgSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN---PEEY
|  ||| ||   |  | ...  .      || |||.    . ..|..||||. ||   ||...   |...|.... .|| |  || ||          | 
kdlnrypniqcwdrgrftlagde....nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

GRLVVTPLEEEELSHYVIRKFCIEIANSDVESPARE--IVQYHYTAWPDHGVPTHATSllafIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQ
 |.      | |.      |    . .  | .  .|  . .| ...|||||.|    .      |.  .| .|  |.. ||||||||||| .....|.  
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdt....alrllsavkkdkkpviahcsagvgrtgtlaliesmiaa

MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEA
. .    ..       | .|   |.. .||..   ...| 
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 46-139 6.6e-20 66.1 In-house 48-156 (350) alignment
Range on Protein: 46-139
Range on HMM: 48-156/350.0
KPKNRYQNIVA-DHTRVAIS--------ELDGIPGSDYINANFIDGY------NHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQ
  ||||.||.  .|.|| .             . ..||||||..         |   |.||||.|. .|.|||.... . .   |...|. || .  ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

KYWPSANPE
.||.  . .
rYWqegsyd

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 47-277 3.5e-20 66.6 In-house 53-282 (302) alignment
Range on Protein: 47-277
Range on HMM: 53-282/302.0
PKNRYQNI-VADHTRVAISELDgipgSDYINANFIDGYNHRNKFIATQGPVSNTF---DDFWRMVWEHGCSCIVMVTNIVERGKlKCQKYWP--SANPEE
 ||. ... ..|...| ...       .|.||  ..  . ... | .| |....    ..|||||... .  .|..    |  |   ....|  | . .|
kknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyke

YGRLVVTPLEEEELSHYViRKFCIEIANSDVE-SPAREIvqYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQ
||.. |     |. .  .  ...||.   ..  |.  ..  |. | |... ||.. ..| . .  . .. .    ..|.    |.|| |. ..| . ...
ygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanv..yvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavek

MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALM
. |. .. |   |   | ||  .|..  ||.... ||.
lqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 50-166 3.5e-11 37.1 In-house 39-157 (332) alignment
Range on Protein: 50-166
Range on HMM: 39-157/332.0
RYQNI-VADHTRVAISELDGIpgSDYINANFIDGYNHRNKFIATQGPVSNTF-DDFWRMVWEHGCSCIVMVTNIVERGKLKCQkYWPSANPEEY---GRL
|   . . ||.|| ..  ||    |. ||...|||.... .| .| |. .     ||||| |.  | |... .| |. | |.  |  |    |      .
riphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap.ydisdrgfeksflhef

VVTPLEEEELSHYVIRKFCIEI
    ||| ||   . |||  | 
gaksleecelkakicrkfwpek

0044763 (Phosphotyrosine protein) phosphatases II 57-279 5.6e-42 138.7 In-house 3-170 (178) alignment
Range on Protein: 57-279
Range on HMM: 3-170/178.0
DHTRVAISELDGIPGSDYINANFIDGYnhrnKFIATQGPvsntfDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPeeygrlvvtpleeeelsh
|.||| .|.| |...||||||..|...     ......|      |......|.|...||..|. .|.|.||| .|||. .                   
drtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

yvirkfcieiansdvespareiVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLDQmskegAVDIFGFVSHTR
                      .||... .||||||.    .|.|.. |.. .... ||..|||||||||.|| .... |. .      ....  ... |
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

LQRNmMVQTEAQYIFIHDALMEA
 .|. .|... |. ....  .. 
erRp.ivpnpgqlrqLyefelrl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 62-137 2.5e-12 40.8 In-house 80-157 (349) alignment
Range on Protein: 62-137
Range on HMM: 80-157/349.0
AISELDGIPGSDYINANFID--GYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN
. || |.    ||||||..    ..  .|.|||| |.  | |||....   |   .. ...  | .  ||..||   .
stsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 65-191 8.1e-13 42.8 In-house 6-126 (130) alignment
Range on Protein: 65-191
Range on HMM: 6-126/130.0
ELDGIPGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERgklkcQKYWPSANPEE-YGRLVVTPLEEEELSHYvIRKFC
|.. ..| .||||.|.   .. .... || |...|  |||.|. |     .|..  . |      ..||| ..| | |   ..  | . . ... |.   
evsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefkn.ikasn

IEIaNSDVESPAREIVQYHYTAWPDHGV
.|| .||.    . .  .. . ||  | 
lei.esdlneshqaltmfqisnwpsdgt

0051429 (Phosphotyrosine protein) phosphatases II 69-280 1.5e-62 206.9 In-house 1-225 (272) alignment
Range on Protein: 69-280
Range on HMM: 1-225/272.0
IPGSDYINANFIDGYNH---RNKFIATQGPVSNTFDDFWRMvWEHGCSCIVMVTNIVERGKLKCQKYWP------------SANPEEYGRLVVTPLEEEE
.| |.||||....||..   ........||  .| .||||. .|.|...||.... .|||.||| .|||            || . .||.|.|| |.|| 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LSHYVIRKFCIEIANSDVESpaREIVQYHYTAWPDHGVPTHAtsLLAFIRRIRNsvsrdAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVD------
|..|..|......  |  |.  ||. ..|||.|||||||..|  ||.... ...      ||..||||||..||||...|. .| ..|.|  ||      
lldyilrellltlllsagea..revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--IFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
  ....|.. | ||  .||||.||.|...||.|..
lyleeaveelraqrpgavqteeqylflyeallell

0046846 (Phosphotyrosine protein) phosphatases II 69-278 3.2e-49 162.3 In-house 9-171 (176) alignment
Range on Protein: 69-278
Range on HMM: 9-171/176.0
IPGSDYINANFIDGYnhrnKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYgrlvvtpleeeelshyvirkfcieian
 ...||||||.|.|.    ..||||||. .|. ||..|..|.|....|..|. || |.|||  |||    ...                           
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

sdvespareivQYHYTAWPDHGVPTHaTSLLAFIRRIRNSVSRDaGPIVVHCSAGVGRTGTYIVLDamldQMSKEGAVDIFGFVSHTRLQRN-MMVQTEA
           ||... |||||||.. . || ... ||. .... ||..||||||.|||||.....     . .|  ....  ... | ||  ..|||..
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYIFIHDALME
|| |.......
Qyrflyefell

0043147 (Phosphotyrosine protein) phosphatases II 70-273 7.6e-51 167.5 In-house 3-154 (172) alignment
Range on Protein: 70-273
Range on HMM: 3-154/172.0
PGSDYINANFIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIvergklkcqkywpsanpeeygrlvvtpleeeelshyvirkfcieiaNS
.|||||||...|.| . ..||||||| .||..|||||..|.|...||..|.                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................ly

DVESPAREIVQYHYTAWPDHGVPtHATSLLAFIRRIRN-SVSRDAGPIVVHCSAGVGRTGTYIVLDAMLdqmskeGAVDIFGFVSHTRLQRNMMVQTEAQ
| |   |...||.|. ||||||| ..  || |.. |..  . .. ||..|||||||||||| .... ||        ....  |.. | .|...||.. |
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YIFIH
|.|..
yrfly

0036282 (Phosphotyrosine protein) phosphatases II 71-274 1.5e-55 182.9 In-house 1-164 (174) alignment
Range on Protein: 71-274
Range on HMM: 1-164/174.0
GSDYINANFIDGYNHRNKFIATQGPVSntfddFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSanpeeygrlvvtpleeeelshyvirkfcieiansD
|||||||...|..   ...||.||| .     ||.|..|.|....||... .|.|. ||  |||.                                  .
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................l

VESPAREIVQYHYTAWPDHGVPTHATsLLAFIRRIRNSVSR-DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSkEGAVDIFGFVSHTRLQRNMMVQTEAQY
 |.. |...||.|. |||||||. .. || |...... .|. . ||..|||||||||||| .... || ..  |..||.. .|   |||| .||||. ||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

IFIHD
.|...
rflyy

0051082 (Phosphotyrosine protein) phosphatases II 71-276 5.9e-41 134.9 In-house 2-149 (151) alignment
Range on Protein: 71-276
Range on HMM: 2-149/151.0
GSDYINANFIDGYnhrnkFIATQGPvsntFDDFWRMVWEHGCSCIVMVTNIVERGklKCQKYWPSANpeeygrlvvtpleeeelshyvirkfcieiansd
 |||||.....|.     .....||     .||.....|.|...||.... .|||  .| .|.|...                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

vespaREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNsvsRDAGPIVVHCSAGVGRTGTYIVLDAMLdQMskegaVDIFGFVSHTRLQRNMMVQTEAQYI
     .|....... |||.|.|..  ..|.|.. ...    . ||..||||||.||||| ..|. || ..     |...  ... ||.| ..||.. |..
.....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqfl

FIHDAL
|.. ||
fqlfal

0049260 (Phosphotyrosine protein) phosphatases II 79-274 1.3e-48 159.8 In-house 1-144 (152) alignment
Range on Protein: 79-274
Range on HMM: 1-144/152.0
FIDGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWpsanpeeygrlvvtpleeeelshyvirkfcieiansdvesparei
|||||.. ..||||||| .||..|||||..|.|...|||.|. .|.||||| .|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

vQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMLdqmskeGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHD
 ||... |||||||...  || ... |.    .. ||..||||||||||||..... ||        |... .|.. | .|...|... |..|...
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 80-274 1.2e-23 78.0 In-house 83-286 (302) alignment
Range on Protein: 80-274
Range on HMM: 83-286/302.0
IDGYNHRNKFIAT-QGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPE--EYGRLVVTPLE-EEELSHYVIRK----FCIEIANSDV
.|| ....|       |  .| . .| .. ..  . .| ....|| .. || .|.     .  ..||  |. .. ...|...  .|    . .|| |. .
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

ESPAREIVQ-YHYTAWPDHGVPTHATSLLAFIRRIrNSVSRDagpIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYI
..  .  |.  ...|||||| | .| . |  ..   .|  ..   ..|||||||||||| . .   ..  ||.   |.   |   |  |   ||.| | |
kkkvkktvdilafsawpdhGapkeaytaldilkfc.esykkn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

FI----HD
..      
ylllcvtk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 81-136 2.4e-10 34.4 In-house 230-282 (440) alignment
Range on Protein: 81-136
Range on HMM: 230-282/440.0
DGYNHRNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERgklKCQKYWPSA
.|| ..| ||||| |.  |  ||||.| ..  | |.|. .. ..    |  |||  
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvn

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 86-273 6.6e-25 82.4 In-house 4-197 (199) alignment
Range on Protein: 86-273
Range on HMM: 4-197/199.0
RNKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN--PEEYGRLVVTPLEEEELSHYVIRKFcIEIANSDVESPAREIVQYHY
. ..|||| |. .|. |||.|||| |   |||| .     .     |||...    .|| | ||       . |.|  . |   |.     .||| .| .
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital.iltnnttappstreishyqf

TAWPDHGVPTHATsLLAFIRRIRNS---VS-RDAGPIVVHCSAGVGRTGTYIVLDAML--DQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIH
|.| ..  |  |  .. |.   |.           |..|||| | | || .. ||  .   . ||   ||.|      |  |  .. .  .| ||.
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 87-273 7.7e-25 82.2 In-house 4-196 (198) alignment
Range on Protein: 87-273
Range on HMM: 4-196/198.0
NKFIATQGPVSNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSAN--PEEYGRLVVTPLEEEELSHYVIRKFcIEIANSDVESPAREIVQYHYT
 ..|||| |. .|. |||.|||| |   |||| .     .     |||...    .|| | ||       . |.|  . |   |.     .||| .| .|
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytital.iltnnttappstreishyqft

AWPDHGVPTHATsLLAFIRRIRNS---VS-RDAGPIVVHCSAGVGRTGTYIVLDAML--DQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIH
.| ..  |  |  .. |.   |.           |..|||| | | || .. ||  .   . ||   ||.|      |  |  .. .  .| ||.
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 97-271 3.7e-20 67.1 In-house 38-212 (255) alignment
Range on Protein: 97-271
Range on HMM: 38-212/255.0
SNTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDvESPAREIVQYHYTAWPDHGVPTHAT
| | | |....   . . .||...  | |. ||..|.|    |      |.    .  .. |.|   |    ..    ....  |.|. |...  |  | 
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlge.kkkthtvkhysykGWieknaPelar

SLLAFIRRIRNSvsRdagPIVVHCSAGVGRTGTYIVLDAMLDQM------SKEGAVDIFGFVSHTRLQRNMMVQTEAQYIF
 .|  .. .|.|  .   ..|||||.|.||. .... . .  .|      .. . .|   .. ..| .|.  ..|  |  |
eilnilkvvrds..k...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf

subfamily_hpo-7_pd Subfamily hpo-7 98-292 2.2e-16 54.5 In-house 45-243 (263) alignment
Range on Protein: 98-292
Range on HMM: 45-243/263.0
NTFDDFWRMVWEHGCSCIVMVTNIVERGKLKCQKYWPSANPEEYGRLVVTPLEEEELSHYVIRKFCIEIANSDvESPAREIVQYHYTAWPDHGVPTHATS
.| | |....   . . .||...  | |. ||..|.|    |      |.    .  |  ...   .    ..     ... .| |. |...  |. | .
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge.KkkthtvkhysykgWiekndpelare

LLAFIRRIRNSvsRdagPIVVHCSAGVGRTGTYIVLDAMLDQ------MSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIF----IHDALMEAAKCGNTEF
 |  ..  |||  .   ..|||||.|.||.  . | . .  .       .. . .|   .. ..| .|.  ..|  |  |    . | ....   |. | 
ilnilkvarns..k...slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgelea

KVQDL
| |..
kyqei

subfamily_PTEN_pd Subfamily PTEN 149-272 1.4e-08 29.9 In-house 54-172 (184) alignment
Range on Protein: 149-272
Range on HMM: 54-172/184.0
LEEEELSHYVIRKFCIEIaNSDVESPAREIVQYHYTawpDHGVPThATSLLAFIRRIRNSVSRDAGP-IVVHCSAGVGRTGTYIVLdAMLDQMSKEGAVD
||..   || |  .. |  . | ..   .. .|  .   ||  |.    | .... |.. ...|    .|||| || ||||. ||   .| ..  | | .
lekkhkdhykiynlrser.kydskkfdgrvavypfd...Dhnppp.lelleeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaee

IFGFVSHTRLQRNMMVQTEAQYIFI
.  . ...| . .  |.  .|  ..
alelfaeaRtknkkgvtiPsqrRYv

subfamily_VSP_pd Subfamily VSP 149-271 2.9e-07 24.6 In-house 68-190 (212) alignment
Range on Protein: 149-271
Range on HMM: 68-190/212.0
LEEEELSHYVIRKFCIEIANsDVESPAREIVQyhyTAWPDHGVPTHaTSLLAFIRRIRNSVSRDAGPIV-VHCSAGVGRTGTYIVLDAMLDQMSK--EGA
|..    || .   | | |  | .   .....       || ||.    || | ..... ...|   .. .||  | ||||| .    .  .. .  . .
ldtkhrdhykvvnlcseray.dekyfnnrvkr...iliddhnvpkl.eellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakes

VDIFGFVSHTRLQRN--MMVQTEAQYIF
.| ||     . . .    ||| .|. .
ldyfgerrtdktegekfqGvqtpsqkry

0048076 (Phosphotyrosine protein) phosphatases II 153-277 4.4e-29 96.4 In-house 24-140 (145) alignment
Range on Protein: 153-277
Range on HMM: 24-140/145.0
ELSHYVIRK-FCIeiaNSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDaGPIVVHCSAGVGRTGTYIVLDAMLDqmskEGaVDIFGF
.| .. |.  ...    |. | . |...||.|. |||||||. .  ||.|.. |.. .... ||..||||||||||||..... ||     .| |...  
llkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleea

VSHTRLQRNMMVQTEAQYIFIHDALM
. . | || ..|... |..|......
lelvrsqrpgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 156-274 6.3e-29 95.9 In-house 30-139 (144) alignment
Range on Protein: 156-274
Range on HMM: 30-139/144.0
HYVIRKFCIEianSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDaGPIVVHCSAGVGRTGTYIVLDAMLdqmsKEGaVDIFGFVSHT
.. .  .. |    . |.. ||..||... |||||||.... ||.|.. |.. .... ||..||||||||||||..... |.    |.| ....  . . 
ittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalv

RLQRNMMVQTEAQYIFIHD
| .| ..|... |..|...
rsrrpgavpnpgqlrfLle

PTEN_1 162-229 4.1e-10 34.8 In-house 74-146 (196) alignment
Range on Protein: 162-229
Range on HMM: 74-146/196.0
FCIEIAN----SDVESPAREIVQYHYTAWPDHGVPTHAtSLLAFIRRIRNSVSRD--AGPIVVHCSAGVGRTGT
.. | ..     | |.  .. |.|.   ..|||.|. . .|....... .....|   . ..||| ||.||.||
lseeeelsgrsydleeffksgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGt

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 165-277 1.2e-14 48.8 In-house 208-341 (350) alignment
Range on Protein: 165-277
Range on HMM: 208-341/350.0
EIANSDvespAREIVQYHYTAWPDHGVPTHATSLLAFIR----RI-----RNS-VSRDAGPIVVHCSAGVGRTGTYIVLDAMLD-----QMSKE------
..| ||      .. | ..  |.| ..  .  |.|  .      |     ..   .  . ||.||||||||||||.. || .|      .. ..      
tlaasd....PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkld

----GAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALM
        |.  | . | ||  |||.  |.|||..||.
vaaktrDlisiivnelrkqrismvqnldqfifiYeall

0038934 (Phosphotyrosine protein) phosphatases II 168-251 4.9e-11 38.1 In-house 69-154 (194) alignment
Range on Protein: 168-251
Range on HMM: 69-154/194.0
NSDVESPAREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDA-GPIVVHCSAGVGRTGTYIVLDAML-DQMSKEGAVDIFGF
  |.|   .  ..|.   .||.|..     || |.. .   ...|. | ..||| ||.||||| ..   .   .|| | |...| .
yYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfre

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 170-278 2.1e-10 34.5 In-house 213-342 (349) alignment
Range on Protein: 170-278
Range on HMM: 213-342/349.0
DVESPArEIVQYHYTAWPDHGVPTHATSLLAFIRrIRNSV-----------SRDAGPIVVHCSAGVGRTGTYIVLDAMLD--QMSKEGAVD---------
.||.|  |..|  .  |.| ..     |.|  .  ..| .           . .  ...|||||| ||||... || .|.  .. ..  .          
avekPy.ellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkD

-IFGFVSHTRLQRNMMVQTEAQYIFIHDALME
 |.  | . | ||  |||  ||.|.|..||..
lisiivnelrkqrismvqnlaqfiaiyealLk

subfamily_PTPDC1_pd Subfamily PTPDC1 172-274 1.7e-09 32.4 In-house 76-170 (182) alignment
Range on Protein: 172-274
Range on HMM: 76-170/182.0
ESPAREIVQYHYTAWPDHGVPTHaTSLLAFIRRIRNSVSRDagPIVVHCSAGVGRTGTYIVLDAML-DQMSKEGAVDIfgfvshTRLQRNMMVQTEAQYI
|. ... . ..  .|.|.||..  ...|  .. .  .....   . ||| || ||||  |    .  .... | |...       | .|   .||  |  
ealmeqgiyvynfgwkDygvasl.eriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaikl......vrskrpksiqtreqve

FIHD
....
lvke

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 175-317 1.5e-31 104.2 In-house 88-231 (440) alignment
Range on Protein: 175-317
Range on HMM: 88-231/440.0
AREIVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSR-DAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIH
.| . |||| .|||.|||  |  .| .|. . .|  .   ||..||||||.||||  |..|..| .  .   .||| |..  | .|  ||||  || |.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DALMEAAKCGNTEFKVQDLHDRIKALQSRDPDSGETYIAKEFKN
.|..|.  ||.|    .|. .|.. .|  .| . .. . .||. 
eavlegllcgdtliledditerveqiqwpnphtdksplqqefeg

PTPc_DSPc_SM00012 178-278 4.1e-37 121.9 In-house 2-105 (105) alignment
Range on Protein: 178-278
Range on HMM: 2-105/105.0
IVQYHYTAWPDHGVPTHATSLLAFIRRIRNSVSRDA--GPIVVHCSAGVGRTGTYIVLDAMLDQMSKE-GAVDIFGFVSHTRLQRNMMVQTEAQYIFIHD
. .||||.|||||||....|.| ..| .... .  .  .|.|||||||||||||...|| .|.|..|| . |||| .|.. | ||. |||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALME
||.|
alle

PTPlike_phytase Inositol hexakisphosphate 179-237 1.1e-06 23.3 Pfam-A 93-148 (149) alignment
Range on Protein: 179-237
Range on HMM: 93-148/149.0
VQYHYTAWPDHGVPTHAtSLLAFIRRIRNSvSRdAGPIVVHCSAGVGRTGTYIVLDAML
|.|.  . .|.  |...  . ||.| |... .|    .|..|.|| ||| |..|.  .|
vkYvRipitdeqapeee.dvDafvrliksl.pr.dtalvfnCqaGrgRTTtamviadLl

PTPlike_phytase Inositol hexakisphosphate 179-237 1.1e-06 23.3 In-house 93-148 (149) alignment
Range on Protein: 179-237
Range on HMM: 93-148/149.0
VQYHYTAWPDHGVPTHAtSLLAFIRRIRNSvSRdAGPIVVHCSAGVGRTGTYIVLDAML
|.|.  . .|.  |...  . ||.| |... .|    .|..|.|| ||| |..|.  .|
vkYvRipitdeqapeee.dvDafvrliksl.pr.dtalvfnCqaGrgRTTtamviadLl

0048567 (Phosphotyrosine protein) phosphatases II 181-237 3.1e-06 21.6 In-house 40-101 (157) alignment
Range on Protein: 181-237
Range on HMM: 40-101/157.0
YHYTAWPDHGvPTHATSLLAFIRRIRNS---VSRDAGPIVVHCSAGV---GRTGTYIVLDAML
.... . |.| | . . |  ||... .    ..   ..|.|||.||    |||.| | . ..|
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlil

PTPc_motif_SM00404 193-241 5.1e-06 21.4 In-house 64-109 (140) alignment
Range on Protein: 193-241
Range on HMM: 64-109/140.0
THATSLLAFIRRIrnsvSRDAGPIVVHCSAGVGRTGTYIVLDAMLD-QMS
 .  ..|.||...     .. | ..||| ||| |..| |.   |   |.|
kyldkvldfiena....ekkggkvlVHCqaGvSRSatliiaYlmryrqls

subfamily_CDC14_pd Subfamily CDC14 202-252 3.4e-06 21.1 In-house 252-300 (328) alignment
Range on Protein: 202-252
Range on HMM: 252-300/328.0
IRRIRNSVSRDAGPIVVHCSAGVGRTGTYIVLDAMldQMSKEGAVDIFGFV
...  . . .  | |.||| ||.||||| |    |  .  .  | .. ...
vkkfleiaekaeGaiavhCkaGLGrtGtLiacylm..khyrftaaeaiawl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 206-278 1.8e-14 48.3 In-house 222-293 (297) alignment
Range on Protein: 206-278
Range on HMM: 222-293/297.0
RNSVSRDAgPIVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALME
|    |.| ...|||||||||.|  .  |..|... |.   |.  ..|. | || ..|||  |. ...|| ..
raemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_CG42327_pd Subfamily CG42327 211-280 1.3e-14 48.6 In-house 245-315 (319) alignment
Range on Protein: 211-280
Range on HMM: 245-315/319.0
RDAGPIVVHCSAGVGRTGTYIVLDAMLDQMSKE-GAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAA
 . ||.||||| ||||||. |  |  . .. .   .|||   ||. | .|   |.|  || ||.  | | |
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 216-283 1.5e-20 67.4 In-house 1-68 (69) alignment
Range on Protein: 216-283
Range on HMM: 1-68/69.0
IVVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCG
.|||||.| |||||.| .   . ..  |  ||||  | . |  | |||  | .||||||||.|| | |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 217-283 1.3e-19 64.3 In-house 1-67 (69) alignment
Range on Protein: 217-283
Range on HMM: 1-67/69.0
VVHCSAGVGRTGTYIVLDAMLDQMSKEGAVDIFGFVSHTRLQRNMMVQTEAQYIFIHDALMEAAKCG
|||||.| |||||.| .   . ..  |  ||||  | . |  | |||  | .|.||||||.|| | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 274-480 2.6e-13 44.2 In-house 33-236 (244) alignment
Range on Protein: 274-480
Range on HMM: 33-236/244.0
DALMEAAKCGNTEFKVQDLhDRIKALQSRDPDSGETYIAKEFK--NLDIGDSDVETFDSASMPENKSKNRF-LVLPYDRTRVKLwpYPGVLGSDYINASF
.|.. |  . |   ..  . |  . . |     |  ||  ..   . .|   |   .  |  |.|  |||    ||.|  || |    | .|  ||||||
navlsanatknryinilpf.detrvilssskkegsdyinanyiqgsqniirpdpsvmkdafnpnnswknregaglpfdfnrvpl..skgsmgntyinasf

IDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIkvrlKQTPDKGEFVVYGLlMVEVESEERQEG-YIK-RQLKISNTKSSEVRNVFH
.    .   .. || ||  |  |||.|. |     .|.|    |.     .  ||   .  |    . |   .|.|   ||  .|.|        . .  
vgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyee.ditvtltdrdefknikasnleiesdmneshqaltm

FQYEDWPEDGVP
||  .|| ||  
fqisnwpsdgtt

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 283-576 5.9e-89 293.2 In-house 1-297 (298) alignment
Range on Protein: 283-576
Range on HMM: 1-297/298.0
GNTEFKVQDLHDRIKALQSRDPDSGETYIAKEFKNLDIGDS--DVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREA
|||| ...||.  .. |.. ... . |  |.||..|. . |  . |. . |. ||||.|||.  ....| .|| |    .   ||||||||...|..|.|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPDKGEfVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDG
|.||||||..|..|||||..|... |.|||..  |  |.. ..  ||.|.   || . |.. |.|..  .|.|.||.|..|... |.| ....  ||. |
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

VPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYA
||.  . |.|.|... . |||.|| |..|.||.| ||.|||.||.  ||||| . ..|.||.|. ||..|| .||| |||.|.||.| .....|.|..
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0051299 (Phosphotyrosine protein) phosphatases II 283-569 1.1e-88 292.8 In-house 1-286 (288) alignment
Range on Protein: 283-569
Range on HMM: 1-286/288.0
GNTEFKVQDLHDRIKALQsrdpDSGETYIAKEFKNLDIGDSDvETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFL
|.||..|..|......|.     .| |....||. |     |  |. .|..|||..|||.  .||||..|||| ...|| ||||||||.|| |..  .|.
gdteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

ATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNT----KSSEVRNVFHFQYEDWPED
|||.||..|..|||||.||... ..|||.|  |. ..   |    |....|| ..|.  ||| ...|..|.|...|.    ...|.|.| ||.| .||..
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVPQDGKLVIDMLKHIARAQQqTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
|||.. .|..|.|... .|..  |.||. ||||.| ||||||.|. ..||...   ..|....|. ||.||| ||||||||.|.||.. ...
gvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPN6_pd Subfamily PTPN6 285-571 4.4e-73 240.9 In-house 2-299 (306) alignment
Range on Protein: 285-571
Range on HMM: 2-299/306.0
TEFKVQDLHDRIKALQSRDPDSGETYIAKEFKNLDIG-DSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWpYPGVLGSDYINASFID--SYQQREAF
|..  .....|.. |.  . . . . . .||..|.    ... . . .. ||||.|||.  .||.| |||.|   |.| |||||||..|.  . ......
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksy

LATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVR-LKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKIS-NTKSSEVRNVFHFQYEDWPEDG
.|||  ||||..|||||.|. .|  .||. |. |  | .  .  ||. |   || . |.  ||.... || |.|..| ..|..| |.||......||. |
iatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhg

VPQDGKLVIDMLKHIARAQQQTG---NGPITVHCSDGSGRTGTFCAISIALERV---KLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEA
||.| . |.|.|... | |...    .||| ||||.| ||||||  | | |. .   .||| ||. ..|. .|.||  .||| .|||| |.......|.
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 297-578 6.2e-64 210.7 In-house 8-287 (287) alignment
Range on Protein: 297-578
Range on HMM: 8-287/287.0
KALQSRDPDSGETYIAKEFKNLDIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWpypgVLGSDYINASFIDSYQQREAFLATQAPLETTINDFW
  .  .... |..   . |. |.  . . .    .  ..|| |||.  .|..|  || |         |||||.|||.|... ||.....|.  |. .||
gefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfW

RMLWEYESYTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTK-SSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIA
..... .  ..||| .. || .    |   ... ||.|   .|. .||...|||.|.|.. |.. ... ..|  .|. .|.. |  .. . .. ....  
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy

RAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYANF
..|.. ||..| |||||. ||...|||. ......| . .||.|| ... | |.| .||| ||||| ...| .....|. |..|
ktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf

0039614 (Phosphotyrosine protein) phosphatases II 299-570 5.9e-82 270.8 In-house 22-290 (297) alignment
Range on Protein: 299-570
Range on HMM: 22-290/297.0
LQSRDPDSGETYIAKEFKNLDIGDSDvetFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGV-LGSDYINASFIDSYQQ-REAFLATQAPLETTINDFW
|. ... .. |.. .||..|     |   .  |  ||||.|||.  .||||..|||| |..|| |.|||||||..| | .   .|.|||.||. |..|||
llllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

RMLWEYESYTVVMLNKDSENIKVRLKQTPDKGEfvVYGLLMVEVESEERQEGYIKRQLKISNtkSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR
||.||. . ..|||.|  |. .   .  |..|.  .|| . |.. ..|  .||. |.|...|  ..|.| | |||| .||..|||.. .|....|. . .
rmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvre

AQQQT-GNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
|.... ..||. ||||.| ||||||.|. ..||...   ..|....|. || ||| .||||.||.|.|....... 
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

subfamily_PTPN9_pd Subfamily PTPN9 299-569 4.8e-72 237.5 In-house 6-290 (297) alignment
Range on Protein: 299-569
Range on HMM: 6-290/297.0
LQSRDPDSGETYIAKEFKNLDIgDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRM
| .   . |.  . ||....    . . ||. . .. | .|||.  || ||.|||.|   ..   ||||||.|.| |.|..||.||| ||. |..|||||
lvayvkekgkrGlskeyaeirn.epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrm

LWEYESYTVVMLNKDSENIKVRLKQTP--DKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR
.|| |  ..||  .  |. ... .|    ....   .| | |.. . | .| | .|.|.|.|.| .| |.| |||.  ||. |||.... ..|.|... .
vWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvre

AQQQ------------TGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
.| .            . . || |||| | ||||||... |.|.|..  .|.|...||. |||||  ..||||||.|||  |  . 
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

0050432 (Phosphotyrosine protein) phosphatases II 300-575 1.5e-85 282.5 In-house 33-305 (308) alignment
Range on Protein: 300-575
Range on HMM: 33-305/308.0
QSRDPDSGETYIAKEFKNLdIGDSDVETFDSASMPENKSKNR-FLVLPYDRTRVKLwpypGvLGSDYINASFIDSY--QQREAFLATQAPLETTINDFWR
.  ..  . ... .||. |     .......|..||||.|||   .||||..||||    .  ||||||||..| |   .. .|.|||.||..|..||||
kllekaldlglleeefeel.lsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MLWEYESYTVVMLNKDSENIKVRLKQ--TPDK-GEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHI
|.||... ..|||.|  || ..   |   ..  |....|| . |.. ||| ...|..|.|...|....|.| | ||.| .||..|||.. . ..|.|...
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

ARAQqqtGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDY
 . .   ..||| ||||.| ||||||.|. ..||... . ..|.|..|. ||.||| ||||||||.|.|... .... .  .
rksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 301-566 3.5e-69 228.5 In-house 26-288 (319) alignment
Range on Protein: 301-566
Range on HMM: 26-288/319.0
SRDPDSGETYIAKEFKNLDIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLW
 .| |   | .  ||...     .  . . | ...|| |||.  .|..|...||| .  |. .||||||||.. ||... ..|.| ||. |..|||||.|
ksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiw

EYESYTVVMLNKDSENikvrlKQTPDKGEfVVYGLLMVEVESEERQEGYIKRQLKISN-TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR-AQ
||.. |.|.| ||        .  | |.. . ..   |.|.| |  . |. |....|. .|  ..|..  | .  ||. |||. .  .. ..|..    .
eyncstivlltkdkcs.....qywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts

QQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
.. .. .| |||| |.||||.. .. . |.|.| .  .|....||.|| ||. .||   ||||.|  . 
kenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall

0047943 (Phosphotyrosine protein) phosphatases II 303-569 3.6e-81 267.9 In-house 6-272 (273) alignment
Range on Protein: 303-569
Range on HMM: 6-272/273.0
DPDSGETYIAKEFKNLdIGDSDVETFDSASMPENKSKNRF-LVLPYDRTRVKLwpypGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEY
.. .| |....||. | .   .. |.  |..||||.|||.  .||||..||||    |  ||||||||..| |..  .|.|||.||. |..|||||.||.
ekllgltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

ESYTVVMLNKDSEN--IKVRLKQTPDKGE-FVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQ
 . ..|||... |.  .|      .. || ...|| . |.. |||  ..|..|.|...|....|.| | ||.| .||..|||.. . ........ .|..
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

QT-GNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
.. .|||. ||||.| ||||||.|. ..|....   ..|....|. ||.||| ||||||||.|.||.. ...
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 303-569 6.1e-79 261.2 In-house 21-304 (307) alignment
Range on Protein: 303-569
Range on HMM: 21-304/307.0
DPDSGETYIAKEFKNLDIGDSD-VETFDSASMPENKSKNRF-LVLPYDRTRVKLWPYPGV-LGSDYINASFI--------DSYQQREAFLATQAPLETTI
.. .. | ..|||. |     . . ....|..||||.|||.  .||||.||||| ...|   .|||||||..        |.| .  .|.|||.||. |.
llldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

NDFWRMLWEYESYTVVMLNKDSEN-IKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNT-KSSEVRNVFHFQYEDWPEDGVPQDGKLVIDM
.||||||||. . ..|||... |.  .   .  ||.||...|| . |.. ||| ..||. |.|..... ...|.| | ||.| .||..|||.. . ..|.
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldf

LKHIARAQQQT-GNGPITVHCSDGSGRTGTFCAISIALERVKLDAT---IDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
.. . .|.... ..||. ||||.| ||||||.|. ..|.... . |   .|....|. || ||| .||.||||.|.||......
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0036941 (Phosphotyrosine protein) phosphatases II 304-570 5.1e-80 264.2 In-house 8-278 (297) alignment
Range on Protein: 304-570
Range on HMM: 8-278/297.0
PDSGETYIAKEFKNLdIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLwpypGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYE
. .. ... |||. |        ... |. |||..|||.  .||||.|||||    .  ||||||||..| |..  .|.|||.||..|..|||||.||. 
kllflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

SYTVVMLNKDSENIKVR-LKQTPDK-GEFVVYGLLMVEVESEER--QEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQ
. ..|||... |. ..   .  |.. ||...|| ..|.. |.|    ..|. |.|....|...|.| | ||.| .||..|||.. . ..|... . ....
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

QT-GNGPITVHCSDGSGRTGTFCAISIALERVK---LDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
.. ..||. ||||.| ||.|||.|. ..|....      ..|....|. ||.||| .|||.|||.|.||.. ... 
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk

subfamily_PTPN23_pd Subfamily PTPN23 305-570 9.9e-59 193.5 In-house 11-281 (288) alignment
Range on Protein: 305-570
Range on HMM: 11-281/288.0
DSGETYIAKEFKNLDIGD-SDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWpypgVLGSDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEY
 .|.| . |.||.|.  .  . . .  |    . .|||.  .||||..||||         |||||||. .       |.||||||..|.||||.|..| 
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

ESYTVVMLNKDSENIKVRLKQ--TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR---A
 | ..||| . .|  | . ..    |||| |..| | | ..|... | ...|.||..  ....|..| | |.. ||| |||.  . ....|. .     |
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayea

QQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDAT-IDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
.|.  . |. |||| |.||||.|. .  |.. .. .   .|. | |. ||.||  |||. ||.||.||.| . ..
vqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 305-572 1.4e-31 104.6 In-house 12-281 (307) alignment
Range on Protein: 305-572
Range on HMM: 12-281/307.0
DSGETYIAKEFKNLDigDSDVETFDSASMPENKSKNRFLVLP-YDRTRVKLwPYPGvLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYES
| | . .  ||..|   . . |.    ..  |  |||.  ..  |..|. .  ..| | |||| | ..    .   |...| |||.|. .|| |  . . 
dkgvqalvdefrvla..kktpegvtveafsantdknryqdvkcqdkgrivv.kfdg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekv

YTVVMLNKDSENIKVRLKQT--PDKGEFVVYGLLMVEVESE-------ERQEGYIK-RQLKISntKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHI
 .|.|| |  |  |.. .|    ..|.  |.|     .  .         .| .|.  .||.    ... | . |.|.|.||. ||||     |..|. .
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvd..waqksrtiqhlqwenwpdrgvpqinltainlleav

ARAQQqtgngPITVHCSDGSGRTGTFCAISIALERV-KLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV-RHFVEAF
   .      |. |||| | ||.||  |||.  ... .     || . |..||.||.  .||  || . . |.  .|.| .
rydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflely

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 306-569 1.1e-72 239.5 In-house 18-279 (288) alignment
Range on Protein: 306-569
Range on HMM: 18-279/288.0
SGETYIAKEFKNLDIGDSDVETfDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESY
...| . .|...|   ... .. . .. ..|..|||.  .|||| .||||   . . |.||||||.||.........|||.||  |.||||.. .|... 
rnrtgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

TVVMLNKDSENIKVRLKQ-TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISntKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTgNG
|.|||..  |. | . ..  ||... . || . |.. ... .| ...|.| .   |. . ... ..||  ||..|||.. . ....|. .  |.|.   |
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tg

PITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
||.||||.| |||||| |.  ....|. . .||.. || .|| ||. .||| .|| |.|||. . .
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 307-573 2.1e-132 436.0 In-house 21-287 (319) alignment
Range on Protein: 307-573
Range on HMM: 21-287/319.0
GETYIAKEFKNLDIGDSDveTFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYT
|||...||||.|.....|  ||||||..|||.|||.  .|.||||||.|....|| |||||||||||.||.||.|.|||||||.||.|||||.||.||..
getllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessi

VVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKIsNTKSSEV--RNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNG
||||.|..|..||.||..... .|..|| |.|..|.||..|.||.|.||. |.|||||  |.|.||||..||...||.......|.||.|......| .|
vvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

PITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFS
||.||||.|.||||||......|||||.....|.|.||..|||||.||||.||||||.||.....|||..
PivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 307-577 1.8e-93 308.1 In-house 18-288 (318) alignment
Range on Protein: 307-577
Range on HMM: 18-288/318.0
GETYIAKEFKNLDIGDSDVETFDSaSMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYT
||... .|...|.  .. | ...|   | || |||.  .|.||.||||| .  |. |||||||..|| |....|..|.||||  ||.|||||.|| .| .
Gelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

VVMLNKDSENIKVRLKQT-PDKGEfVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGP
.||| . .|. |.....  |.||    || |.||...| . . |. |..|...|...|.|.|  ..| .||. |||..|  ..|..... .|||..|.||
ivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

ITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYAN
|.|||| | ||||.|.|..| |||.| .|..|.||||..||.||..|||| .||.|.|.|.  .....  ...
ivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd

subfamily_PTPRB_pd Subfamily PTPRB 307-570 1.9e-70 232.2 In-house 23-286 (293) alignment
Range on Protein: 307-570
Range on HMM: 23-286/293.0
GETYIAKEFKNLDIGDSDVeTFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYT
 .. ...|...|   ..|  . ..|. ..|..|||.  .|||| .|||| .  .  |||||||..|. |...  |.||| || .|..|||||.|| .| .
sdlrfseeyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

VVMLNKDSENIKVRLKQ-TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNtkSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQ-QQTGNG
.||| .  |. ||. ..  |.. | |.|| . |.. .||..| .. |.|||..  ..| |.| ....  ||. |||.. | ..|..... .|. ... ..
ivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

PITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
||.|||| | |||||| |.   |.... . ..|.| .| .||..| ..||| .|| | ...| ....
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_PTPRG_pd Subfamily PTPRG 307-570 1.3e-69 229.9 In-house 17-288 (563) alignment
Range on Protein: 307-570
Range on HMM: 17-288/563.0
GETYIAKEFKNLDIGDSDV-ETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGS-DYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYES
|.. ...||..|     .   . .... |||| ||| | ...|||.|||| | ||. .. |||||..|| ||. .||.||| ||..|..|||||.|| ..
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

YTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTK-----S-SEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQ
 ..||. .  |. .   ..   | | . || | |  ..||.   | .|.|.| |.|     .  ....| ...| .||. |||.    |. . |. ..|.
aiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

QQTgNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
...  |||.|||| | |||||.....  |.... . ....|.... .|.||. .||| ||| | ....   . 
kae.aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 307-575 9.1e-66 216.7 In-house 18-289 (290) alignment
Range on Protein: 307-575
Range on HMM: 18-289/290.0
GETYIAKEFKNLDIGDSDVETfDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVL--GSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYES
|..   ..|| || |.|. ..   .  ..|| .|||  ...||  |. | | .|      .||||..|. |.......|||.|.. |. |||...|. ..
gnegfrnqfkmldsgesehtv.tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekv

YTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKS-SEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGN
  .||| .  |. ||. .|   . .   ||   ... .||  ..||.|.|.. |..|  . ..| ..|   |...|  .. . .. ..... . | ..||
tiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgn

GPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDY
..| |||||. ||...|||. ......| .  ||.|| ....|.|.| .||| .||.. ...| . .. |. |
tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

0040438 (Phosphotyrosine protein) phosphatases II 308-569 7.5e-85 280.3 In-house 17-276 (317) alignment
Range on Protein: 308-569
Range on HMM: 17-276/317.0
ETYIAKEFKNLDIGDSDveTFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTV
 |.. .||..|.  . |  |.. |..||||.|||.  .||||..|||| |..|.|.|||||||..| .... .|.|||.||. |..|||||.||. . ..
ftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

VMLNKDSEN-IKVRLKQTPDkGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqTGNGPI
|||..  |.  .   .  |. ||...|| ..|.. |||  .|.. |.|.......||.| | ||.| .||..|||.. .|..|.|. . .|..  ..||.
vmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpv

TVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
 ||||.| ||||||.|. ..||...   ..|....|. || ||| .|||||||.|.|.......
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0043336 (Phosphotyrosine protein) phosphatases II 308-568 4e-81 267.8 In-house 19-276 (278) alignment
Range on Protein: 308-568
Range on HMM: 19-276/278.0
ETYIAKEFKNLDIGDSdvETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTV
 | . .||..|.  .   .|.. |  ||||.|||.  .||||..||||....|.|.|||||||..| |.. ..|.|||.||. |..|||||.||. . |.
ktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VMLNKDSENIKVRLKQTPDkGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqTGNGPIT
|||... |. .|   |    |....|| . |.. .|| ...|. |.|...|....|.| | |..| .||..||| . .|..|.|| . .|.. . |||. 
vmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvl

VHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
||||.| ||||||.|. ..||...   ..|....|. ||.||| .||||.||.|.||.....
VHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Ptp69D_pd Subfamily Ptp69D 308-568 7.1e-73 240.4 In-house 21-285 (307) alignment
Range on Protein: 308-568
Range on HMM: 21-285/307.0
ETYIAKEFKNLDIGDSDVETFDsASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTV
.  .|||...|    .| .|   .   ||. |||.  . ..|.||||| . .|   ||||||||| .|.... |.| |.|.|.||.|||||..| |....
dfglakeyekLeareidkstkv.sekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLNKDSENIKVRL-KQTPDKgEFVVYGLLMVEVESEERQEGYIKRQLKISNTK-----SSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQT
||| . .|  . .  |  |.  . | || ..|.. |||... ||.|.|..|..|       . |.|  ..|  |..  ||.  . ........   ... 
vmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln

gNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
 ..||.|||| |.||.|.| |... |...|.. ..|.|.||..|| ||...||  |||.|.|  .  .
.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 308-569 8.6e-46 151.1 In-house 5-259 (267) alignment
Range on Protein: 308-569
Range on HMM: 5-259/267.0
ETYIAKEFKNLDIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYpgvlGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTV
|. | |||....   ..  |       .|. .||.  .|||| ||| |         .|||||....|....||..|| ||. || ||. .. ...  ..
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk....eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLNKDSENiKVRLKQTPDKGEFVVYGLLMVEVESEERQEGY--IKRQLKISNtksSEVRNVFHFQYEDWPEDGvpQDGKLVIDMLKHIARAQQQTGNGP
|.| |  .. ..||   |  |.   |  | ||   |. .. |  |  .||. |      .||  . |. |  .   ..   .  ..  .|. | . || |
vlltkvftd.nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn...esahnvtlyyykkwnint..nnkpylkplfgilaknqlengnrP

ITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
. |.|||| ||.|||  |   |||.| . . |.|. .|..| ||. .|.| |.| ...|.. .. 
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 308-569 8.3e-21 68.7 In-house 25-285 (302) alignment
Range on Protein: 308-569
Range on HMM: 25-285/302.0
ETYIAKEFKNLDIGDSDVETfdSASMPENKSKNRFLVLP-YDRTRVKLWPYPgvlgSDYINASFIDSYQQREAFLATQAPLETTI---NDFWRMLWEYES
.. . ||||..|    |.|     .  .| .||.   .| .| ..|||   |     .|.||| ..  . ..  . .| |  ..    ..|||| .. . 
taevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

YTVVMLNKDSENIKvRLKQ-TP-DKGEFVVYGLLMVEVESEERQEGYI-KRQLKI--SNTKSSEVRNVFHFQYedWPEDGVPQDGKLVIDMLKHIaRAQQ
 .||.| .. |  |  |..  |   |... || ..| .   |..|.   .  . .   .   | . || ....  |... ||.    .|   ...  |..
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakv.fakk

QTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
. .. .. .    |.|| |.| .  .|.|... ..   . ..|...|.||| .|.. .|| . | ..  ..
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_PTPRN_pd Subfamily PTPRN 309-571 1.3e-51 170.1 In-house 29-294 (297) alignment
Range on Protein: 309-571
Range on HMM: 29-294/297.0
TYIAKEFKNLDIGDSDVETFDSASMPENKSKNR-FLVLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQR-EAFLATQAPLETTINDFWRMLWEYESYTV
. ..||.. |   ... .| . |. ..| .|||   ||||| .||||        |||||||.|   . |  |..|||.|| .|. |||.|.||  .  .
drlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

VMLNKDSE-NIKVRLKQTPDKGEfVVYGLLMVEVESEE-RQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQtGNGP
|.| . .| ..|   .  ||.|.  ||..  |.. ||    . |. | . . | ..|| | |  | .  ||| |||   | .... . . .. .     |
vnltrleeegvkqckrywpdeGs.evyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscp

ITVHCSDGSGRTGTFCAISIALERVKLDA-TIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEA
| ||||||.||||....| . |.|..  .  ||.  |.  || ||| .|.| .|..|.. .| . |.|
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevna

DSPc_SM00195 311-569 1.1e-78 259.5 In-house 2-262 (263) alignment
Range on Protein: 311-569
Range on HMM: 2-262/263.0
IAKEFKNLDIGDSDVeTFDSASMPENKSKNRF-LVLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVML
. .||..|.  .|.  ....|  ..||||||.  .||||.||||| . ..  |||||||..|. ....... |||.||..|..||||| || .. ..|||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NKDSENIKVRLKQ-TPDK-GEFVVYGLLMVEVESEERQE-GYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTgNGPIT
....|| | . ..  |.. |.  ..| . |.. ..| ..  .|.|.|...... .| |.| ..||..||. |||.. | |...|. .   .... .||| 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
||||.| ||||||..|.|.|.... . ..|.|..|..||.||| |||| |||.|.||.. ...
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 311-569 1.1e-78 259.5 In-house 2-262 (263) alignment
Range on Protein: 311-569
Range on HMM: 2-262/263.0
IAKEFKNLDIGDSDVeTFDSASMPENKSKNRF-LVLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVML
. .||..|.  .|.  ....|  ..||||||.  .||||.||||| . ..  |||||||..|. ....... |||.||..|..||||| || .. ..|||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

NKDSENIKVRLKQ-TPDK-GEFVVYGLLMVEVESEERQE-GYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTgNGPIT
....|| | . ..  |.. |.  ..| . |.. ..| ..  .|.|.|...... .| |.| ..||..||. |||.. | |...|. .   .... .||| 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
||||.| ||||||..|.|.|.... . ..|.|..|..||.||| |||| |||.|.||.. ...
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 311-569 3e-65 215.1 In-house 17-276 (281) alignment
Range on Protein: 311-569
Range on HMM: 17-276/281.0
IAKEFKNLDigDSDVETFDSASM-PENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVM
 ..|...|   . .|.   .||  .||. |||.  .  || ||||. |      .|||||.|...|.. ....|||.|. .....||.|.||..  ..||
fieeyekla..aigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivm

LNKDSENIKVRLKQ-TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKIsNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITV
. .. |. |..  .  ||. . . || ..|. ..||... ||.|..|. ...|.| |.| ...|  ||. |||.. | ...  | . .....  . |. .
vtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSDGSGRTGTFCAISIALERVKLD-ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
||| | |||||. |.  ....|. . ...|. ..|..|| .| .||||  ||.| | .| . .
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 311-577 6.1e-58 190.9 In-house 17-301 (301) alignment
Range on Protein: 311-577
Range on HMM: 17-301/301.0
IAKEFKNLDIGDSDVETFDSASmpENKSKNRFL-VLPYDRTRVKLWPYP--GVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVV
.....|.|. |...  |    .  |||  |||  . .||  |. | | |   .   .|||||.||.|.....| |.|.|.. |. ||||..|..   ..|
feeqykelkegedksctvglse..enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQ-------------------EGYIKRQLKISNTKssEVRNVFHFQYEDWPEDGVPQDGKLVID
|. .  |..| . .|   ..|   .    ..|.  . |                   .|||.|..|....|  . ..|  .|  |||.||| .. . |. 
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLq

MLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYAN
 .  .  .||. | ||. |||||. .|.|..|..||.|| .| .  .|.|| .. .| ..| .|.| ||| . |.|.  ...  | |||
viddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 311-568 8e-50 164.2 In-house 12-276 (287) alignment
Range on Protein: 311-568
Range on HMM: 12-276/287.0
IAKEFKNLDI-GDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWpYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVM
. ||...|    .|   || .|    . .|||.  |||.| ||| |    | |||||||| .. ||.. |||.|.|.|. .|..||||...| .| .|..
vdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LNKDSENIKVR-LKQTPDKGE-FVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQD----GKLVIDMLKHIARAQQQTGN
. .. |. . .  |  |..     | |  .| .. . ..  |  | |.. . .. | | |  ... .||.....       ..|.|. .||  |.. .. 
mtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasev

GPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
||. ||.. | ||.|.. |. . ..| .    .|. ..|  || .|  .||.. |... || .  .
GPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty

subfamily_ptpA1_pd Subfamily ptpA1 311-529 2.7e-35 116.9 In-house 23-256 (418) alignment
Range on Protein: 311-529
Range on HMM: 23-256/418.0
IAKEFKNLDIGDSDVETFDSAsMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQReAFLATQAPLETTINDFWRMLWEYESYTVVML
| .||. |.      || .      | ||||.  .|| ..|||.|       ||||||| .||    .  |..|| ||  || |||||.||     .|||
ikeefrlleesvgpsetsegd.kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivml

NKDSENIKVRLKQ-TPDK--G-EFVVYG----------LLMVEVESEERQEgYIKRQLKIsnTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR
...||| ...  .  |..  | .| .||          . .|||  .  .|  | |....  |   | |.. ..||| ||.  .|.  . . ..|. |. 
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpere.iitrnirl..tfegetrditqyqyegwpdhnipdhtqpfrqllhsitn

AQQQT-----GNGPITVHCSDGSGRTGTFCAISIALERV
 |.|       | || |||| | |||||||.  | ....
rqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 311-570 6.1e-27 89.0 In-house 29-291 (310) alignment
Range on Protein: 311-570
Range on HMM: 29-291/310.0
IAKEFKNLDIGDSDVETFDSasMPENKSKNRFL-VLPYDRTRVKLWPYPgVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVML
..|....||  .    |...  . ..  |||.  |.  | .||||         ||| | .. .   |..|. .| ||. || |||||...  . ....|
lvkqyrkldakqdssltyea..ykkymhknrysdvvcldtsrvklkidk.sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilll

NKDSENIKVR-LKQTPDKGEFVVYGLLMVEVESEERQEGYIK--------RQLKISNTKS-SEVRNVFHFQYEDWPEDGVPQDGKLVIDmlkhiARAQQQ
 | .|. . . .   |  |    || . |   ||  .|  |          .. . .  .  .   |   .. .||. |||..    .       |   |
ckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.....qrllaq

TGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
   ||  |||| | .|... .|. .......    .|. . . .|. .| | .||. || .   |   |. 
vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar

subfamily_CG42327_pd Subfamily CG42327 311-493 5.7e-24 79.4 In-house 7-190 (319) alignment
Range on Protein: 311-493
Range on HMM: 7-190/319.0
IAKEFKNLD--IGDSDvetfdsASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQR-EAFLATQAPLETTINDFWRMLWEYESYTV
.|.||..|   |  .|      .  .  | |.|.. |.|   ||| |   .    . |..||..  |..    ..|.|..|| .  ||||..||  | ..
vaeefrdlPqliarad......evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvi

VMLNKDSENI-KVRLKQTPDKG---EFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYeDWPEDGVPQDGKLVIDMLKHI
| | . ||.  ||  .  | |    .  .|| ..| .   | .. |.   | . . . .| |.. |. | .|.| .|| . . .| || ..
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllev

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 311-384 6.2e-10 33.1 In-house 25-94 (95) alignment
Range on Protein: 311-384
Range on HMM: 25-94/95.0
IAKEFKNLDIGDSDVETfdSASMPENKSKNRFL-VLPYDRTRVKLWpypGVLGSDYINASFIDSYQQREAFLATQ
. .||| . .      |    |   |  ||||| ..||| ||| |        |||||| |.| | ......|.|
fdnefksismtsgapyt..vgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaq

0046845 (Phosphotyrosine protein) phosphatases II 312-576 1.8e-82 272.2 In-house 3-281 (284) alignment
Range on Protein: 312-576
Range on HMM: 3-281/284.0
AKEFKNLDIGDSDVE-TFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGV-LGSDYINASFIDSY-----QQREAFLATQAPLETTINDFWRMLWEYES
 .||. |     ... ... | .|||.||||.  .||||..|||| ...|   .|||||||..| |      .. .|.|||.||..|..|||||.||...
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

YTVVMLNKDSENIKVRLK-QTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTK-SSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQ-T
 ..|||..  || ..      |..||...|| ..|.. ||| ...|..| |...|.. ..|.| | ||.| .||..|||.. . ....|. . .....  
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GNGPITVHCSDGSGRTGTFCAISIALERVKLDA---TIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYA
|.||| ||||.| ||||||.|. ..||... .    ..|....|. ||.||| ||||.|||.|.||.. ...  .  ..
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll

subfamily_PTPRA_pd Subfamily PTPRA 312-568 3.4e-80 264.4 In-house 35-294 (330) alignment
Range on Protein: 312-568
Range on HMM: 35-294/330.0
AKEFKNLDIGDSDvETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLN
 .||..|  |. .  |.. ||  ||| |||.. .|||| .|| | .  ||  |||||||||| |.... |.|.| |.| |..|||||.||..| |.||| 
reefnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

KDSENIKVRLKQT-PDKGeFVVYGLLMVEVESEERQEGYIKRQLKIS----NTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNgPI
.  |  . . .|  ||.|  | || . |||| |.  . |  |.. .     .|.  ..| |  | .. ||. ||| ... ....||.. . .||... ||
elkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pi

TVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
.|||| | ||||||....  ||||| .  .|.|..|..||.||| |||| |||.|.|.|....
vvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_PTPN13_pd Subfamily PTPN13 312-566 2.1e-58 192.8 In-house 14-266 (273) alignment
Range on Protein: 312-566
Range on HMM: 14-266/273.0
AKEFKNLDIGDsDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGvlgsdYINASFIDSYQQRE--AFLATQAPLETTINDFWRMLWEYESYTVVM
|.|||.|      ..| ...   |||.|||.  |||||.|||||    |     |||||.|    . .   ..|.| || .|..|||.|.|| ..  ..|
aeefkelrelk.pldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LNKDSENIKVRLKQ-TPD--KGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqtGNGPI
. .. |. ||. ..  |.  . . .|.. | ||..  ....|.  |.|......|.|.|.| |... .||. |||.  . .. ......| |.   .|||
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPi

TVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
 |||| | ||.||. .| ..|. .. |  .|. ..||.|| ||  .||| .|| |.|... 
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail

subfamily_PTPN14_pd Subfamily PTPN14 312-570 1.7e-54 179.9 In-house 26-297 (300) alignment
Range on Protein: 312-570
Range on HMM: 26-297/300.0
AKEFKNLDIGDSDvETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVlGSDYINASFIDSY--QQREAFLATQAPLETTINDFWRMLWEYESYTVVM
 .|. ..     |  ....|..|||..||||  ||||. .||.| |      ..||||| |      ..  ....|.|||.|..|||.|.|| . . .||
fteyeripkkred.allstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LNKDSENIKVRL-KQTPDK---GEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIA---RAQQQT-
| .. |. | .  |  |..    . | .|   |  .  |  . .| ..||.    |.| |.|.|.|| |||..|||.| |  .. |...    |. ... 
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

----GNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
     . |. ||||.| ||||      . .. .. . .||. .... ||.|| ..|||  |||| |.|. ....
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 312-565 4e-54 178.4 In-house 12-262 (283) alignment
Range on Protein: 312-565
Range on HMM: 12-262/283.0
AKEFKNLDIGDSDVetfDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGvlgsDYINASFID---SYQQREAFLATQAPLETTINDFWRMLWEYESYTVV
 . .|.| . | |.   | ||  ||| |||.  ..|.|. ||.| . .     |||||.||    ||.| . ....|.||. |. |||.|... .  ..|
revlkrlsvpdlda...diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLNKDSENIKVRLKQT-PDKGeFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSE--VRnVFHFQYEDWpedgVPQDGKLVIDML---KHIARAQQQTG
|| |  |. ...  |  | .|  . || . | .. |  .. .|...| . .  |..  .  . |.|..||    .  . . .|. |     .   |..  
mltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidW....leygeqaiinslvkfnkvislqtesk

NGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
.||| |||| | |||..|.|.| ... .. .. .|.|..|...| ||. .||| .|||. .|.|
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 312-573 4.9e-31 102.4 In-house 14-273 (281) alignment
Range on Protein: 312-573
Range on HMM: 14-273/281.0
AKEFKNLDiGDSDVETFDSASMPENKSKNRFLVLP-YDRTRVKLWP-YPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVML
 .|| ||  ||   .       | |. |||.| .|  | .||.|    |    .||| | .| |   .  .. || | . |  |||||.|. .. ..|||
kqefsnlp.gdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

NKDSENIKVRLKQTPDKGEFV--VYGLLMVEVESEERQEGYIKRQLKISNtkSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIaRAQqqtgNGPITV
 .  |  . .  .   .   .   .  | |. |    ..  .  .|..|     | | . |. ...||.  ||.  .... .|..| ||.      |  .
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrki.rar....stppvi

HCSDGSGRTGTFCAISIALERVKLDATI-DMFQTVRNLR-TQRPIMVQTPEQYKFCYEVVRHFVEAFS
||| | ||.||. |. |||. ..   |. |. | |  || | |   ||| .|| . ..|.  |  |. 
hcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 313-572 1.6e-75 249.1 In-house 26-286 (305) alignment
Range on Protein: 313-572
Range on HMM: 26-286/305.0
KEFKNLDIGdsdVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLN-
...|.|       |..|  .  .||.|||.  . ..|  |..| . . .  |||||||..|.|.........|.||..|..||||...|.   |.|||  
aqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk

-KDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISN-TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITVH
 .. .. | |   .  |.| . .| ..||..||.  ..||.|.||||.  ...| |.| ..|  |||..||||    .....|.. ..|..  . |..||
lveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVh

CSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAF
||.| ||||.|.|..|||||.| . ..|.|. ...||..|. |||| .|| |.....   ....
CsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 319-568 3.2e-64 211.7 In-house 27-276 (315) alignment
Range on Protein: 319-568
Range on HMM: 27-276/315.0
DIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIK
|. | |.    .|  ..| .|||.  .||.|..||||        |||||||.| |... .|..|.|.||.....|||||.....  |.||..| .|. |
dlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdk

VRLKQT-PD-KGEFVVYGLLMVEVESEERQEGYIKRQLkiSNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIaRAQQQTGNGPITVHCSDGSGR
.. .|  || |.. | .| . ||. | | . . ..|.|     || | |.|  ||...||. ||...   .. ..| . .|.... . .. |||| | ||
ikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikev.kadngkkefsllvhcsaGvGr

TGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
|| ...|   ....|   ..|.|..|.|||..|| .||| |.| | |..|.  
tGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 319-565 1.2e-45 150.5 In-house 28-232 (392) alignment
Range on Protein: 319-565
Range on HMM: 28-232/392.0
DIGDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIk
|. . |.    .|  . |. |||.  .||||..||||     .  |||.|||.|.|... .|..|.|.|  ....|||||... .  |..|..|  |   
dlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.

vrlkqtpdkgefvvygllmveveseerqegyikrqlkisntKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIaRAQQQTGNGPITVHCSDGSGRTG
                                         |  ..| |  |.. .||...||.    .. ..| . .|.      |. .||| | ||||
.........................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtg

TFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
   .|   . . |    .|.|. | |.| .|| |||| ||| | |  |
vvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 321-566 2.4e-67 222.4 In-house 10-252 (284) alignment
Range on Protein: 321-566
Range on HMM: 10-252/284.0
GDSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENikvr
   .  .   | ...|| |||.  .|..|...||| .  |. .|||||||||  ||... ..||| ||. |..|||||.|||.. |.|.| ||       
lgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltkdkcs....

lKQTPDKGEfVVYGLLMVEVESEERQEGYIKRQLKISN-TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAR-AQQQTGNGPITVHCSDGSGRTG
 .  | |.. . ..   |.|.| |  | |. |....|. .|  ..|..  | .  ||. |||. .  .. ..|..    ... .. .| |||| |.||||
.qywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtg

TFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
.. .. . |.|.| .  .|....||.|| ||. .||   ||||.|  . 
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 322-484 1.9e-20 67.9 In-house 19-184 (297) alignment
Range on Protein: 322-484
Range on HMM: 19-184/297.0
DSDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPypGVLGSDYINASFIDSYQQRE--AFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKV
..  |.| ||  .    |||.  .| .| |||||    .. ..||||| ..   .. .   .. .| ||..|..|||....| .  ..||. |  |. . 
eargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

RLKQ-TP-DKGEFVVYGLLMVEVESEERQEgYIKRQL-KISNTKSSEVRNVFHFQYEDWPEDGVPQDGK
.     |  ..|    | ..||  |.  .| . . .| ..     || | | | |.  ||. ||| | .
kcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdle

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 323-569 2e-60 199.4 In-house 36-280 (315) alignment
Range on Protein: 323-569
Range on HMM: 36-280/315.0
SDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLK
 ..  .| |   ||| |||.  ...||..||.|       .|||.||.||| |.... ..|.|.|. ....||||...|..  ..|||..  |. | . .
gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkae

-QTPDKgeFVVYGLLMVEVESEERQEGYIKRQLkiSNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGnGPITVHCSDGSGRTGTFC
   |||   |.|| . |   ||| .. |  | |  | .  ...|.|. ..|  ||. |||.    .... ... . ....  |.| ||||.| ||||||.
kywpdk..kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfi

AISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV-RHFV
...  |.... .  ||... ....| .|  |||. |||.| |...   ||
tldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv

subfamily_egg_pd Subfamily egg 323-570 2.5e-24 80.5 In-house 27-271 (307) alignment
Range on Protein: 323-570
Range on HMM: 27-271/307.0
SDVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLN--KDSENIKVR
.| ...  |   .|. | |   |   | .||||    |    |.| |  ..     . |. .||||  | .|||||... |   .|||.  |.||. .  
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyy

LKQTPDKGEFVVYGLLMVEVES-EERQEG-YIKRQLKISNTKsSEVRNVFHFQYeDWPEDGvpqDGKLVIDMLkhiaRAQQQTgNGPITVHCSDGSGRTG
  .....   .| | | .|    ... .  .   .||.  ..  | | . |.|. |. . .   |    . .|    |  ..    |. |.. .|  ...
wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwqg.dvnnss...dvysplrvl....rklrnl.skpvvvqdilGvskaa

TFCAISIALERVKLDATI--DMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
|. || |||  .    .    . ..|  || .|.. |... .| | | .|  |. 
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr

0045098 (Phosphotyrosine protein) phosphatases II 324-570 3.8e-73 241.6 In-house 21-273 (278) alignment
Range on Protein: 324-570
Range on HMM: 21-273/278.0
DVETFDSASMPENKSKNRFL-VLPYDRTRVKlwpypgvlgsDYINASFIDSYqqREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ
.. ..  | ...|..|||.  .||||..|||          ||||||.||.|  . .|.|||.||..|..||||||||. . ..|||..  |. ..   |
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNT----KSSEVRNVFHFQYEDWPEDGVPQDG--KLVIDMLKHIARAQQ------------QTGNGP
    |....|| . |...|||. . |..| |.. |.    .. | |.|.|..|  ||. ||| .   | ....|. | .|..            . ..||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ITVHCSDGSGRTGTFCAISIALERVklDATIDMFQTVRNLRTQRPI-MVQTPEQYKFCYEVVRHFVE
. |||| | |||||..|. . ||..  . ..|....|. ||.|||. .||..|||.|.||.......
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_PTPRK_pd Subfamily PTPRK 324-565 5e-71 234.1 In-house 31-273 (314) alignment
Range on Protein: 324-565
Range on HMM: 31-273/314.0
DVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRL-K
 .| .|.|   ||..|||.  .|.|||.||.| .  |   ||||||..||||.. .||..|| ||. |..||||....... ..|||..  |. .|.  |
lfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClk

QTPDKGEFvvYGLLMVEVESEERQEGYIKRQLKISN--TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQtGNGPITVHCSDGSGRTGTF
  |...|   || . ||. . | .. ...| .....   . .|.| | .||.  ||. .||.  . ........   |.. ..|.| |||| |.||||||
yWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtf

CAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
.||.| |. .. . ..|.|..|..||.... ||.| |||||.|.|.
iaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 324-566 2.6e-58 192.7 In-house 36-285 (325) alignment
Range on Protein: 324-566
Range on HMM: 36-285/325.0
DVETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ
|  ..  |  ||||.||||  |...|..|| |        |||||||.. ...... |||.|||| .||||.||.. ....  ||.||.  .. .   . 
dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavy

TPDK-GEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQ-----QTGNGPITVHCSDGSGRT
 |.. |. . .| | |.. . |    |..|.|.. ..|  | | |  ||.  |.. ||..    .| .|. .   ..       . .|| ||||.| |||
wpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrt

GTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
|.| ..  ||..|  .. .|.|. |..|| .|| ||.| .|| ..|| . 
Gvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 324-570 8.1e-27 88.7 In-house 36-288 (305) alignment
Range on Protein: 324-570
Range on HMM: 36-288/305.0
DVETFDSASMPENKSKNRFL-VLPYDRTRVKLwpyPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENI-KVRLK
|.| . .    ... |||.  |   |. ||||    |    .|| | .. .  . . |. |||||| |  ||| | ..    .. || .  |   |  |.
dfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcle

QTP-DKGE---FVVYG-LLMVEVESEERQE------GYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHiARaqqqTGNGPITVHCS
  . ....   |   |  ..| .|| .. .        ...   . .   ...| | |. . |||. |||     ....|.. ||    .  |||.||||
yfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek.ar....pskgpivvhcs

DGSGRTGTFCAISIALERVKLDATIDMFQ-TVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
 | ||||.   .   |...     |.  .  .. .| ||   .|| .|| | ..|.  ...
agigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

subfamily_PTPRD_pd Subfamily PTPRD 325-575 4e-105 347.6 In-house 37-287 (564) alignment
Range on Protein: 325-575
Range on HMM: 37-287/564.0
VETFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQT
 .|...|..|.||.|||.  ...||..||.| ...|. |||||||||||.|..|.|..|||.||..||.|||||.||..| |.|||.| .|. ||.... 
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

-PDKGeFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQqQTGNGPITVHCSDGSGRTGTFCAI
 |.||    || |.|..|.||. . |. |..|....||||.|.| .|.. .||. |||. .. ..|..... ... ....|||.|||| | ||||||..|
WPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivi

SIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDY
.. |||.| ..|.|..|.|..||.||..||||.||| |..|.. ........ 
damlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 325-574 1.6e-27 91.0 In-house 43-295 (305) alignment
Range on Protein: 325-574
Range on HMM: 43-295/305.0
VETFDSASMP-ENKSKNRFLVLPYD-RTRVKLwPYPGvlGSDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLK
  .|..   .  ...|||.  .| . .. |||   |    |||| | ..         |...| ||. ||..|| |. .     .||| |  |  |..  
qvafnanqsadiaitknryqdvpcqdqsavkl.dkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkca

QTP--DKGEF--VVYGLLMVEVESEERQEGYIKRQLKISNTKS--SEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIaRaqqqTGNGPITVHCSDGSGR
|     .||   .  |... .|      |   . |. . |     ..   | |.|. .||. |||      ...|  | |      . || |||| | ||
qywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai.r....gskvpivvhcsagigr

TGTFCAISIALERVKLDA-TIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV-RHFVEAFSD
|||  ||   ||..  .     | . |. || ||   .|.  || | . |.  .|.| . .
tgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke

subfamily_PTPN3_pd Subfamily PTPN3 327-566 3.8e-59 194.9 In-house 32-272 (280) alignment
Range on Protein: 327-566
Range on HMM: 32-272/280.0
TFDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGvlgsDYINASFID----SYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLK
. . | .||| ||||.  .|||| |||||   .     |||||....    | ..   ..||| ||..| .|||.|.|| .| ..|||    |. .|. .
aisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

Q-TPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAqQQTGNGPITVHCSDGSGRTGTFC
|  |.... . || ..|..|.|.... |. |.| .......| |.....|| .||. |||.| . ........ .. ... . |. |||| | |||| . 
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl.rsgkeePvvvhCsaGigrtGvli

AISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
.. .||  .     . . . ||..| || ..|||..||||  | . 
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail

0040439 (Phosphotyrosine protein) phosphatases II 328-568 3.7e-77 254.6 In-house 3-245 (249) alignment
Range on Protein: 328-568
Range on HMM: 3-245/249.0
FDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDK
.. |..||||.|||.  .||||..|||| ..||. .|||||||.|| |..  .|.|||.||. |..||||||||. . ..|||... |. ..   |  . 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

GEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQT-GNGPITVHCSDGSGRTGTFCAISIA
|....|| ..|.. |.|  ..|. |.|...|.. .|.| | |.|| |||..|||.. . ..|... .  |....  .||. ||||.| ||||||.|. ..
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

LERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
||...   ..|....|. ||.||| .||.||||.|.||.....
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

subfamily_PTPN12_pd Subfamily PTPN12 328-570 1.9e-67 222.2 In-house 32-278 (290) alignment
Range on Protein: 328-570
Range on HMM: 32-278/290.0
FDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPD
 .... .||. |||.  .|||| .||.|    .. |||||||.||   ... ...|.|.|| .|..|||||.||..   |||. .  |. | . ..  |.
teagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpe

KGEFVV-YGLLMVEVESEERQE-GYIKRQLKISNTksSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqTGNGPITVHCSDGSGRTGTFCAIS
.||  . .| . |..|.|.. . ... |.||. .   .| |.|  |.|..||. |||.  | ........ . |. . . |. |||| | ||||| .|| 
egeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaid

IALERVKLDAT---IDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
.. | .| . .   .|.|. |..||.||. .||| |||.. |. | ..|.
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_PTPN1_pd Subfamily PTPN1 328-565 8.6e-49 160.8 In-house 24-267 (290) alignment
Range on Protein: 328-565
Range on HMM: 24-267/290.0
FDSASMPENKSKNRFL-VLPYDRTRVKLWPYPGvlgsDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPD
  .| .|||...||.  | ||| .|.||         ||||||...  . .  .. || ||  |.. ||.|.|| .| .||||||  |. ...  |  | 
treaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

KGE--FVVYG--LLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQ-QTGNGPITVHCSDGSGRTGTFC
. |   ...    | |.. ||||.. |. |.|.. | |. | |...|| |  ||. |||.     ...| .. ..   ..  ||  .||| | ||.||||
geeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc

AISIALERVKL---DATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
 .   | ...     ...|. ... .|| .|  ..||..| .| |  .
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai

0049772 (Phosphotyrosine protein) phosphatases II 328-572 4e-42 140.4 In-house 38-283 (314) alignment
Range on Protein: 328-572
Range on HMM: 38-283/314.0
FDSASMPENKSKNRFL-VLPYDrTRVKLwPYPGVLGSDYINASFIDSYqqrEAFLATQAPLETTINDF----------WRML--WEYESYTVVM------
.  |. ..|..|||.| .||.| .||.| |. .| ||||||||..|..    .|.|||.||| |..||          |||   ... . ..||      
ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LNKDSENIkvrlkqtpdkGEFVVYGLLMVEveseerqegyikrqlKISNTKSSEVRNVFHFQYEDWPEDGVPqDGKLVIDMLKHI
               |.. ..|           .| ..  | . .               .. . ..   |..... . ..| ...| . . . ..|..|
adelsrLdaAlgKtpllildgng..........neptaadlellk...............eelydpelferlgikylripvpDgsap.lledfdeflefi

ARAqqqTGNGPITVHCSDGSGRTGTFCAISIALERVKldatIDMFQTVRNLRTQRP-----IMVQTPEQYKFCYEVVRHFVEAF
 .|     .||. |||..| ||||||... . . . .    ... .... .| .||      .....||| |..|....... .
eea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl

0042113 (Phosphotyrosine protein) phosphatases II 329-569 1.1e-75 249.5 In-house 2-243 (245) alignment
Range on Protein: 329-569
Range on HMM: 2-243/245.0
DSASMPENKSKNRF-LVLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKG
..|. ||||.|||.  .||||.||||| |..| |.|||||||..| |.. . |.|||.||. |..||||||||. . |.|||... |. .|   |    |
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

EFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALE
|...|| ..|.. |||  ..|. |.|...|....|.|.|.|..| .||..||| . .|..|.|. . .|.....|||. ||||.| ||||||.|. ..||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
...   .......|. || ||| .||||.||.|.||......
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 329-568 1.7e-66 219.5 In-house 3-241 (243) alignment
Range on Protein: 329-568
Range on HMM: 3-241/243.0
DSASMPENKSKNRFL-VLPYDRTRVKLwpyPGvlgSDYINASFIDSYQQreaFLATQAPLETTIND----FWRMLWEYESYTVVMLNKDSENIKVRLKQT
  |..|||.||||.  .||||..||||   .|   ||||||..|. . .   . |||.||. |..|    |||||||. . ..|||... |. ..   | 
siallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

PDkGEFvVYGLLMVEVESEERQEGYIKRQLKISNTK-SSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQ-------TGNGPITVHCSDGSGR
   ||. .|| ..|.. |||  ..|. | |...|.. . ..|.|.|..|  ||. |||.. . ..|.|...   ...        ..||. |||| | ||
wp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTFCAISIALERVkldaTIDMFQTVRNLRTQRPI-MVQTPEQYKFCYEVVRHF
|||..|. . |...    ..|....|. ||.|||  .||||.||.|.||.....
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 329-570 1.3e-55 183.4 In-house 21-269 (274) alignment
Range on Protein: 329-570
Range on HMM: 21-269/274.0
DSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLG-SDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRL-KQTP
.  ... ...|||.  .|| ...|| | .  .    |.|||| .|  |..  .|..||| || .|..|||||... |.  .||| | .|. . .  .  |
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

DKGEF---VVYGLLMVEVESEERQEGYIKRQLKISNTKSseVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTG--NGPITVHCSDGSGRTGTF
|. ..     || . ..||.  ....|  |.| ......   |.| |. | |||.  .|.| . ..|..... ......    .|. |||| | |||| |
daedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

CAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVE
 |||||. ... . ..|....| ||| .|  |||| |||.. .... ....
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 329-565 9.2e-24 79.1 In-house 12-255 (290) alignment
Range on Protein: 329-565
Range on HMM: 12-255/290.0
DSASMPENKSKNRFLVLPYDRTRVKLWPYPGVLGSDYINASFIdSYQQREAFLATQAPLET-------TINDFWRMLWEYESYTVVMLNKDSENIKV-RL
..  . ... ..|  |     ||| |  |   . .||| |... .. .  ....||.|.|        ||..|| |  . ..  |||| . .|. .   |
ktdyvkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl

----KQTPDK-GEFVVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVrNVFHFQYEDWPEDGVPQDGKLVIDMLKHIAraQQQTgngPITVHCSDGSGR
    |  |.. || . .. | |.  | | ... ..|.| .   .  |   | | ....| .  |..| |.........   ...|   |. ||| ||  |
faCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvk..askt...pvivHcvdGiSr

TGTFCAISIALERVK-LDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
  .. || ..   .  .   . . . . .|| ||  ........ |   ..
sAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 329-375 3.1e-07 24.1 In-house 40-87 (440) alignment
Range on Protein: 329-375
Range on HMM: 40-87/440.0
DSASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQ
| ||.|.|| |||.  .| ||..|| |    ||  |||||||.|.. .
diaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 331-577 1.1e-77 255.7 In-house 4-250 (250) alignment
Range on Protein: 331-577
Range on HMM: 4-250/250.0
ASMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTP-DKGE
|  |.|| |||.  ....| .|| | .  |   ||||||||...|..|.||.|||.||..||.|||||..|..| |.|||.. .|. |.  .  | .| |
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

fvVYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALER
   || ..|.. |.|    |.||.||.|..| .. | | ....  ||. |||.  . |...||.. . |||.||.|. |.|| | ||.|.|.||.  |||
..kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

VKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFSDYAN
.| . ..|.|. .. ||..|| .|.. ||| |.||.. .......|||.
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 331-569 3.2e-60 198.8 In-house 43-284 (297) alignment
Range on Protein: 331-569
Range on HMM: 43-284/297.0
ASMPENK---SKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQreAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDK
. . |.|   .|.|.  .||||. ||||        |||.||||. ....   ...|| | ..|..|||.|.....  |.||||.|.|. |   .  .||
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk

GEFVvYGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQ--DGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISI
|    .| . |...| ...||.|||.|.... |.   | |  .|. .||.. |..  . . ...... .    .|. .||. |||. | |||| ...|  
gvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

ALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
 . ..| . ..|.|..|. || .|| .||| ||||| |..|  ..
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 331-417 3.1e-14 47.5 In-house 42-143 (350) alignment
Range on Protein: 331-417
Range on HMM: 42-143/350.0
ASMPENKSKNRFL-VLPYDRTRVKLW--PY------PGVLGSDYINASFIDSY----QQREAF--LATQAPLETTINDFWRMLWEYESYTVVMLNKDSEN
..  |  .|||.  .|||...||||   .         . ..|||||...       ..   |  .||||||  |..||.... . .   ...|..| |.
seGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvel

IK
  
nl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 332-571 5.3e-56 184.6 In-house 16-266 (270) alignment
Range on Protein: 332-571
Range on HMM: 16-266/270.0
SMPENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSY-QQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLK----QTPD
..  .|  ||.  .||  .|||.| .      . |||| ..  . .......|...||.||...||||.|| .. ..||. .  |. . . .    . |.
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

KGEFVVYGLLMVEVESEERQEGYIKRQLKISntKSSEVRNVFHFQYEDWPEDGVPQDGK------LVIDMLKHIARAQQQTGNG-PITVHCSDGSGRTGT
.   . .| . | ..|||..||||...|..   ...| |.. ||.|..||..|||..         .. ||... | .... .. |. ||||.| |||||
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

FCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEA
. |. ||.. .. .  .|. . ...|| .|. .||.||||.| |..|....| 
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

subfamily_eak_pd Subfamily eak 332-481 7.5e-17 55.7 In-house 48-196 (332) alignment
Range on Protein: 332-481
Range on HMM: 48-196/332.0
SMPENKSKNRFLVLPYDRTRVKLWPYPgVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSE-NIKVRLKQTPDKG-EF
.  |.  .| . ..||||  |.| .        ||||| ..  .  . .. | .. |. .  ||.|. |  | ..|.| .| | ...   |  |||. | 
arleavnrnvvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

VVYGLLMVEVESEERQEGYIKRQLKISntKSSEVRNVFHFQYEDWPEDGVPQ
. .| | ||  .  ... .  |.|..|  |  |  .|.|...  | |  .|.
lkfGildverkefvkrniletrllels..kGnethrvlhykvfGwtettlpk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 332-404 2.1e-07 24.8 In-house 37-111 (347) alignment
Range on Protein: 332-404
Range on HMM: 37-111/347.0
SMPENKSKNRFLVlpyDRTRVKLWPYPGVLG-----SDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESY
|.  |.||.  |.   | ||| | |     .       ||||| |   . .. .. || ||  |. |||.|.      
slsknrskdvkli...datrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvt

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 333-571 3.8e-33 109.4 In-house 51-285 (290) alignment
Range on Protein: 333-571
Range on HMM: 51-285/290.0
MPENK--SKNRFL-VLPYDRTRVKLWpyPGVLGsDYINASFIDSYQqrEAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPDK-G
. .|    |||.  |   |.||| |    |  | ||. | ...  .    |. || .|. |. |.|||. . .  ..||| .  |. | . .|  |.| |
fdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG

EFVVYGLLMVEVE-SEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAqqqtgNGPITVHCSDGSGRTGTFCAISIAL
| . .| . |    ......  ||. | . . .|     . |..   ||.  |..    .. .|. . .|     .||..|||| | |||||| || ..|
evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievgl

ERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEA
. .     .|. ..|| ||  |   ||   ||    |.. ..  .
qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkd

subfamily_CG7180_pd Subfamily CG7180 334-573 2.3e-55 182.4 In-house 40-294 (296) alignment
Range on Protein: 334-573
Range on HMM: 40-294/296.0
PENKSKNR-FLVLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKGeFVVY
 ||. |||   |.||| .|| |    |   ||||||...||. . .... |.|| . |...|||.... |. .||.| |  .  |  ..  | |.    |
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks.keqy

GLLMVEVESEERQEGYIKRQLKISNT----------KSSEVRNVFHFQYEDWPE-DGVPQDGKLVIDMLKHIARAQQQT----GNGPITVHCSDGSGRTG
| ..||. .|.      .|..|.  .           . |.| | .||.  |.  | ||   . .|.... .   ....     .||. |..|||..|.|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

TFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAFS
 ..|| ..|| |. .  .|.|. |. || .|| .|.. |.||..|.|. ..| .. 
vylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 335-563 1.6e-41 137.0 In-house 7-235 (239) alignment
Range on Protein: 335-563
Range on HMM: 7-235/239.0
ENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQT-PDKGefVV
 ||.|||.  .. ||..|| |        |||||||..  |.   .|..|||  .|..  |||||.|.     .|||    |  | . .|  ||      
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sk

YGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAqQQTGNGPITVHCSDGSGRTGTFCAISIALERVKL
|  | | .   |    || | . .|.   .| | |.....  ||. ||||    |. . ..|..     |  |  .||| | ||||.|  |   | . | 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtgaflvidamlrqakk

DATIDMFQTVRNLRTQRPIMVQTPEQYKFCYE
. |.|.|. |. .| .|| |||| ||| | . 
qktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 335-564 1.9e-41 136.8 In-house 6-235 (239) alignment
Range on Protein: 335-564
Range on HMM: 6-235/239.0
ENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQT-PDKGefVV
 ||.|||.  .. ||..|| |        |||||||..  |.   .|..|||  .|..  |||||.|.     .|||    |  | . .|  ||      
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sk

YGLLMVEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAqQQTGNGPITVHCSDGSGRTGTFCAISIALERVKL
|  | | .   |    || | . .|.   .| | |.....  ||. ||||    |. . ..|..     |  |  .||| | ||||.|  |   | . | 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtgaflvidamlrqakk

DATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
. |.|.|. |. .| .|| |||| ||| | .  
qktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 335-564 5.5e-41 135.3 In-house 2-234 (237) alignment
Range on Protein: 335-564
Range on HMM: 2-234/237.0
ENKSKNRFL-VLPYDRTRVKLWPyPGVlGSDYINASFIDSYQQ-REAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPDKGEFVV
||| |||.  .  || .|| |   .|  |||||||.......     ..|.| |||.. .|||.|.|.     .|||    |. ... ..  |.  .   
enkiknrygnivaydhsrvvlkg.ags.gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGLLMVEVESEERQEGYIKRQLKISN-TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIA-RAQQQTGNGPITVHCSDGSGRTGTFCAISIALERV
|| | | .  .|    |  | | .|. ..  ||| .. .|.  ||. ||||    .. . |.|  |..  .  ||  .||| | |||| |  |   | . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
|    .|... | ..  .|| ..|| .|| | ...
kekkvvdiynyvysieedrpyiiqtkdqyvfihqt

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 335-568 3.5e-27 90.2 In-house 42-270 (288) alignment
Range on Protein: 335-568
Range on HMM: 42-270/288.0
ENKSKNRFLVLPY-DRTRVKLWpypgVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TP-DKGEFVV
.| ...|.  ||  | |||||          ||.|  . | . .. .. .||||..||. .|.|| | .   .|||..  |  | . ..  |  .|| . 
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGLLMVEVESEErqeGYIKRQLKISN---TKSSEVRN-VFHFQYEDWPEDGVPQDGKLVIDMLKHIaraqqQTGNGPITVHCSDGSGRTGTFCAISIALE
.| |   |  .      |.. .|.|    .|  | .  | .  . .|..||||.. .  . .|. .     .. . || ||.| |.|||||.  | ||||
igrlctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililiale

RVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
 ..||  . . . . .|| .|   .||  || . . .| . 
slrlddflgirsllaklreerfkaiqtemqylyvhrcvlee

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 335-568 1.7e-20 67.9 In-house 46-278 (303) alignment
Range on Protein: 335-568
Range on HMM: 46-278/303.0
ENKSKNRFL-VLPYDRTRVKLwpypgvLGSDYINASFIDSYQQREAFLaTQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ-TPDKGEFVVY
.|  ||||  |.  | ..|||        | || ||...   .. | | || ||  |  |||.|. |     |..|  |||  |.  .   | . .|. .
knmdknrfvdvicldhskvkl......sdssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GLLMV---EVESEERQEGYIKRQLKISNTKSSEVRNVFHfqYEDWPEDGVPQD--GKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIAL-
   ..   |    |  .|.  . | .|| .      | |  |..|| . .| |   |.| .. .  .  .. . . |       | ||.|||. .  |  
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhh..ykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

ERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
   . .|..|. . . |.|  |   ||   |. . | ..   
slhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 335-492 3.4e-06 20.1 In-house 26-167 (169) alignment
Range on Protein: 335-492
Range on HMM: 26-167/169.0
ENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINAsfidsyqqreaflatqaplettindfwRMLWEYESYTVVMLN-KDSENI------KVRLKQTPDK
 |..|||    |   .|||||      ||||||||                           ||.|| ..  .|.|   |  |         .|. .   
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

GEFVVYGLLMVE--VESE-ERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKH
||.    | .    |..  .  || ..  . | . ...   ..  ..|  ||..||||    |  ...|
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvghlfhh

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 335-492 4.2e-06 19.7 In-house 25-166 (169) alignment
Range on Protein: 335-492
Range on HMM: 25-166/169.0
ENKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINAsfidsyqqreaflatqaplettindfwRMLWEYESYTVVMLN-KDSENIK------VRLKQTPDK
 |..|||    |   .|||||      ||||||||                           ||.|| ..  .|.|   |  |         .|. .   
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil

GEFVVYGLLmVEVESE----ERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKH
||.    |  |  .         || .. .| | . ...  ...  ..|  ||..||||    |  ...|
Gewytdsly.vrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvghlfhh

Y_phosphatase Protein-tyrosine phosphatase 336-565 7.9e-72 236.8 Pfam-A 1-233 (235) alignment
Range on Protein: 336-565
Range on HMM: 1-233/235.0
NKSKNRF-LVLPYDRTRVKLwpyPGVLG-SDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTP--DKGEFVV
||.|||.  .||||.|||||    |  | ||||||.....|.. ..|.|||.||. ||.|||||.|.... ..|||... |. .. ..|    ...|.. 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGLLMVEVE-SEE-RQEGYIKRQLKISNTKSS-EVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQqQTGNGPITVHCSDGSGRTGTFCAISIALER
|| . ||.. .|.  ...|. |.|.....|.. | | | ...|..||. |||.. | ..|... . . . .. .||..||||.|.||||||.|..|.||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

VKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
.. . ..|..|.|..||.||| |||. |||.|.|...
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 336-565 7.9e-72 236.8 In-house 1-233 (235) alignment
Range on Protein: 336-565
Range on HMM: 1-233/235.0
NKSKNRF-LVLPYDRTRVKLwpyPGVLG-SDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTP--DKGEFVV
||.|||.  .||||.|||||    |  | ||||||.....|.. ..|.|||.||. ||.|||||.|.... ..|||... |. .. ..|    ...|.. 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGLLMVEVE-SEE-RQEGYIKRQLKISNTKSS-EVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQqQTGNGPITVHCSDGSGRTGTFCAISIALER
|| . ||.. .|.  ...|. |.|.....|.. | | | ...|..||. |||.. | ..|... . . . .. .||..||||.|.||||||.|..|.||.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq

VKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
.. . ..|..|.|..||.||| |||. |||.|.|...
leaeeevdvlqivkelRkqRpgmvqsleqYiflykai

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 336-567 1.8e-62 206.1 In-house 43-274 (515) alignment
Range on Protein: 336-567
Range on HMM: 43-274/515.0
NKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRL-KQTPD-KGEFVVY
| .|||.  .||||..||||        |||.|||.| |..   |..|.|.|......||||......  |..|..| .|. |..  |  ||  |. | .
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GLLMVEVESEERQEGYIKRQLKIsnTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGnGPITVHCSDGSGRTGTFCAISIALERVKLD
| . ||. | |   | |||.|..  .|....| |  |....||. |||.. . .. ..| .   ..|    |. .||| | |||| ...|   . ..|  
Gsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahaktt

ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRH
 ..|.|..|.|.| .|| .||| ||| | |..|. 
rmvdvfnfvtnirqkrpylvqtqeqyafiygavle

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 336-566 2.2e-49 163.1 In-house 48-276 (439) alignment
Range on Protein: 336-566
Range on HMM: 48-276/439.0
NKSKNRFL-VLPYDRTRVKLWPYPGVLGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKvrlkQTPDKGEfVVYGL
...|||.  | ..| ||| |   |||  | |||| .|. | . . ..|||.| . | .||||...|  . |.||| .  |  |      | ..| |.|| 
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdae.vcygd

LMVEVESEERQEGYIKRQLKISNTKS--SEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLD
..| |. .     |. | .|. | .      | |..|.|  ||.  || .   |.|.|. |  |...   ||. |||| | |||||  |. ||||..||.
iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkle

ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
  .|.   |. || ||  |||.  || | |. | 
nkvdikgivkvlrkqrkqmvqalcqyvfiynavl

0041856 (Phosphotyrosine protein) phosphatases II 336-568 1.5e-42 140.6 In-house 1-170 (182) alignment
Range on Protein: 336-568
Range on HMM: 1-170/182.0
NKSKNRFL-VLPYDRTRvklwpypgvlGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNkdseN----Ikvrlkqtpdkgefv
|..|||.  .||||..|          ..|||||.......    |.|||.||  |..||.|||.|.   |.|.|.    .                   
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywp..............

vygllmveveseerqegyikrqlkisntkSSEVRNVFHFQYEDWPEDGVPQdgklVIDMLKHIARAQQqtGNGPITVHCSDGSGRTGTFCAISIALERvk
                             . . |......|  || .|||     . ..|. | ....   .||. |||| | |||||..|. . ...  
.............................ellerlgiqylylpwpDhgvpd....ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl..

ldaTIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
    ......|. .| .|| ||.||.|| |.. .....
...gvsleeavklvrsrRpgmvitpnqyfflqlallel

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 336-558 3e-31 103.3 In-house 50-270 (301) alignment
Range on Protein: 336-558
Range on HMM: 50-270/301.0
NKSKNRFLVLPYD-RTRVKLWPYpGVlgSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQ--TPDKGEFVVY
.| |.|.  .| .  | |..    |      | | .|..  . . |.|||.||. | .||| ||  |.  ..||| .  |. . . ..  . . .| .  
pkdkhryptvPckPstavevivd.Gk..rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi

GLLMVEVESEER--QEGYIKRQLKISN-TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqtgngPITVHCSDGSGRTGTFCAISIALERV
|  .......|   ..  .||.|.. . |.  . | | |.||..|.. |||.    . |... . ....     || ||||.| ||. .| .  .   .|
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigteylarev

KLDATIDMFQTVRNLRTQRPIMVQTPEQY
. | ||.. .....|| .|   ||| .| 
eadptieltealkhlrehrwngvqtnsql

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 336-571 2e-18 61.1 In-house 43-278 (312) alignment
Range on Protein: 336-571
Range on HMM: 43-278/312.0
NKSKNRFL-VLPYDRTRVKLWPYpgvlGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVR-LKQTPDKGEF----
 |  ||.  .  .|| |  |          || | |.    . | |..||.||| |.  ||..     | ....|    |.   .  |   |   |    
fkdlnrypniqcwdrgrftlagd....enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

--VVYGLLMVEVESEERQEGY-IKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqtgngPITVHCSDGSGRTGTFCAISIAL
   ||     |.|   .      .| ||.    . .  .. |.|.  ||. |.|.       .|  . . ..     |.  ||| | |||||.. |   .
dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmi

ERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEA
  ..     .. ..   || .|   |..  || ..  .| .|. .
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 344-411 1.5e-07 25.2 In-house 43-109 (332) alignment
Range on Protein: 344-411
Range on HMM: 43-109/332.0
VLPYDRTRVKLWPYPGVlgSDYINASFIDSYQQREAFLATQAPLET-TINDFWRMLWEYESYTVVMLNK
.  .|..||.| |  |    |. |||..| | .. |.. .|||..  |   ||||. | .   ....  
lycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 345-479 2.5e-10 34.8 In-house 3-126 (130) alignment
Range on Protein: 345-479
Range on HMM: 3-126/130.0
LPYDRTRVKlwpypgvlGSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIkvrlKQTPDKGEFVVYGLLMVEVESEER
|... .|..        | .||||||.   ..   .| ||.||  |  |||.|. |     .|.|    |.     .  ||   .  |   ..   ..  
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrd

QEGYIKR-QLKISNTKSSEVRNVFHFQYEDWPEDGV
.  .||  .|.|..      . .  ||  .|| || 
efknikasnleiesdlneshqaltmfqisnwpsdgt

0044763 (Phosphotyrosine protein) phosphatases II 346-567 1.1e-33 111.7 In-house 1-169 (178) alignment
Range on Protein: 346-567
Range on HMM: 1-169/178.0
PYDRTRVKLWPYPGVLGSDYINASFIDSYqqreaFLATQAPLettiNDFWRMLWEYESYTVVMLNKDSENIKVRL-KQTPDK-Gefvvygllmvevesee
|.|||||.|....|...|||||||.|. .     ......|      |....|.|.   ..|.|... |. .. . .. |.. |                
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

rqegyikrqlkisntkssevrnvFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqTGNGPITVHCSDGSGRTGTFCAISIALERvkldaTIDMFQTVRN
                       .....  .| .|||.  . . .... | .|.. . .||. |||| | ||.||..|. . ...      ..... .. 
.......................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

LRTQRPiMVQTPEQYKFCYEVVRH
.| .|| .|..|.|....||. ..
vrerRp.ivpnpgqlrqLyefelr

0046846 (Phosphotyrosine protein) phosphatases II 357-568 4.7e-38 126.0 In-house 6-172 (176) alignment
Range on Protein: 357-568
Range on HMM: 6-172/176.0
YPGVLGSDYINASFIDSYqqreAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDK-----Gefvvygllmveveseerqegyikr
.   |..|||||..|...    ...|||.||. |. ||..||.|.  ..||.|... |  .... . ..                               
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

qlkisntkssevrnvfHFQYEDWPEDGVPQDgKLVIDMLKHIARAQQQTgnGPITVHCSDGSGRTGTFCAISialeRVKLDATIDMFQTVRNLRTQRP-I
                .... .||. |||.. .|....|. | .|...   ||. |||| | |||||..|.      ..|.  ........ .| |||  
................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplg

MVQTPEQYKFCYEVVRHF
.|||||||.|.||.....
avqtpeQyrflyefelll

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 360-415 8.2e-07 22.6 In-house 87-144 (349) alignment
Range on Protein: 360-415
Range on HMM: 87-144/349.0
VLGSDYINASFIDS--YQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSEN
    ||||| ..    ..  . ..|||||| .|..||....   .   |. ||.| |.
gklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel

0036282 (Phosphotyrosine protein) phosphatases II 362-563 4.2e-44 145.6 In-house 1-164 (174) alignment
Range on Protein: 362-563
Range on HMM: 1-164/174.0
GSDYINASFIDSYQQREAFLATQAPLEttindFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKgefvvygllmveveseerqegyikrqlkisnTKSS
||||||||..| .   . ..|.|.||.     ||.||.|. . |||||..  |. ...  .                                   ....
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EVRNVFHFQYEDWPEDGVPQDGKlVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKlDATIDMFQTVRNLRTQRPIMVQTPEQYKFC
..|......|  || .||| . . .....| . .|... ..||. |||| | |||||..|. . | . .   ..| ...|| ||.||| |||||.||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YE
|.
yy

0043147 (Phosphotyrosine protein) phosphatases II 362-564 1.7e-43 143.6 In-house 4-156 (172) alignment
Range on Protein: 362-564
Range on HMM: 4-156/172.0
GSDYINASFIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDsenikvrlkqtpdkgefvvygllmveveseerqegyikrqlkiSNTKSS
||||||||..| |     |.|||.||  |..||||||.|.   ..|.|..                                             .... 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

EVRNVFHFQYEDWPEDGVPqDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALervkldATIDMFQTVRNLRTQRPIMVQTPEQYKFC
..|......|  ||  ||| . .|....|. | .....  .||. |||| | |||||..|. . |        ......|. .|..||..||.|.||.|.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl

YEV
|. 
yyf

0051429 (Phosphotyrosine protein) phosphatases II 363-572 1.6e-49 164.3 In-house 4-228 (272) alignment
Range on Protein: 363-572
Range on HMM: 4-228/272.0
SDYINASFIDSYQQ---REAFLATQAPLETTINDFWRMlWEYESYTVVMLNKDSENIKVR-LKQTP-----------DKGEFVVYGLLMVEVESEERQEG
|.||||.... | .   . .......||. |..||||. .|.   |.|.| ...|  ..   .  |           |  ... || |.| . ||| .. 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YIKRQLKISNT-KSSEVRNVFHFQYEDWPEDGVPQDGklVIDMLKHIARaqqqtgNGPITVHCSDGSGRTGTFCAISIALERVKLDATID--------MF
|| | | .... . .|.| |.|..| ||| .||||.   ....|.....      .||. |||| | .||||..|. . |..| |.. .|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QTVRNLRTQRPIMVQTPEQYKFCYEVVRHFVEAF
..|. || ||| .|||.|||.|.||.........
eaveelraqrpgavqteeqylflyeallellrsl

0051082 (Phosphotyrosine protein) phosphatases II 363-564 5.5e-35 115.5 In-house 3-148 (151) alignment
Range on Protein: 363-564
Range on HMM: 3-148/151.0
SDYINASFIDSYqqreaFLATQAPLEttinDFWRMLWEYESYTVVMLNKDSENIkVRLKQTPDKGefvvygllmveveseerqegyikrqlkisntksse
|||||.|.....     ......||.    ||...|.|.  .|.|.|... |.     .  |. |                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................

vRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARaqqqTGNGPITVHCSDGSGRTGTFCAISIALERvkldatIDMFQTVRNLRTQRPIMVQTPEQYKFCY
 ..|.|....|||. |.|.  . |...|.....    ..|||. |||| | |||||..|. . |..      ........ .| .|| .||...|. |..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

EV
 .
fa

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 363-567 1.1e-27 91.7 In-house 59-268 (285) alignment
Range on Protein: 363-567
Range on HMM: 59-268/285.0
SDYINASFIDSY-QQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSEN--IKVRLKQTPDKGEFVVYGLLMVEVE--SEERQEGYIKRQLKISN
 ||| ||..    ... ....|| ||  |..|||.|... .   |.||    |    |. |      || | .|   . .    ||   | |   | . |
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvin

TK--SSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQtgNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTP
|.  |||   . | |   ||..  |.| . .|.. | . . . .  . || |||| | ||| ||  |  |  |.  .  |.|.. ||..|. |   ||. 
tedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqsh

EQYKFCYEVVRH
 |. | | |.  
mqflflyvvlme

0049260 (Phosphotyrosine protein) phosphatases II 370-563 4.5e-37 122.4 In-house 1-144 (152) alignment
Range on Protein: 370-563
Range on HMM: 1-144/152.0
FIDSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPdkgefvvygllmveveseerqegyikrqlkisntkssevrnvfHF
||| | .  .|.|||.|.. |..||||||.|.   |.|||....|. |.  .| .                                           ..
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QYEDWPEDGVPQDGKLVIDMLKHIARAqQQTGNGPITVHCSDGSGRTGTFCAISIALervkldATIDMFQTVRNLRTQRPIMVQTPEQYKFCYE
..  || .|||..  |....|. | .. ..  .||. |||| | |||||..|. . |        ......|. .|..||..|..|.|..|.||
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 372-412 6.9e-10 32.8 In-house 230-270 (440) alignment
Range on Protein: 372-412
Range on HMM: 230-270/440.0
DSYQQREAFLATQAPLETTINDFWRMLWEYESYTVVMLNKD
. | ...||.||| ||..|. ||||.. .|.  |..|||. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnql

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 378-564 2.1e-24 80.8 In-house 5-199 (199) alignment
Range on Protein: 378-564
Range on HMM: 5-199/199.0
EAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKV--RLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISN--TKSSEVRNVFHFQYED
  ..||| ||  |. |||.|.||  |  .||.| |  | ..   .     .     || | | ...   .  |    | ..|  |     |.. |.|.  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEDGVPQDGKLVID--MLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKL--DATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
| |   |.   .|      . ...  .|  . |. |||||| | || | |. | .   .    . .|.|.  . ||  |  .. . ..|.| |.|
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 378-564 2.4e-24 80.6 In-house 4-198 (198) alignment
Range on Protein: 378-564
Range on HMM: 4-198/198.0
EAFLATQAPLETTINDFWRMLWEYESYTVVMLNKDSENIKV--RLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISN--TKSSEVRNVFHFQYED
  ..||| ||  |. |||.|.||  |  .||.| |  | ..   .     .     || | | ...   .  |    | ..|  |     |.. |.|.  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEDGVPQDGKLVID--MLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKL--DATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
| |   |.   .|      . ...  .|  . |. |||||| | || | |. | .   .    . .|.|.  . ||  |  .. . ..|.| |.|
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 386-560 4.2e-14 46.7 In-house 99-279 (302) alignment
Range on Protein: 386-560
Range on HMM: 99-279/302.0
PLETTINDFWRMLWEYESYTVVMLNK--DSENIKVRL---KQTPDKGEFVVYGLLMVEVESEERQ----EGYIKRQLKISNTKSSE--VRNVFHFQYEDW
|   |.. .| .. .|.   || | .  ..|. |.     ..  .. .|  | .  |.|. .  .    ...   ...| |.|  .   . |  ...  |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PEDGVPQDGKLVIDMLKHIARAQQQtgngpITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKF
|. | |.. .  .|.||.    ...     . |||| | |||||. ||   ..  . . . |. . |  .|. |   ||. .|  .
pdhGapkeaytaldilkfcesykkn.....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 386-569 6.6e-07 22.2 In-house 126-309 (346) alignment
Range on Protein: 386-569
Range on HMM: 126-309/346.0
PLETTINDFWRMLWEYESYTVVMLNKDS--ENIKVRLKqTPDKGEFVVYGLLMVEVESEER---QEGYIKRQLKISNTKSsEVRNVFHfqYEDWPEDGVP
  |. ..||| |... .   | ..  |    |    |    ..| .   | ....    .       |    |   |. |  . .| |  .  |     |
enesfvedfwymiyqeqihlvylmvpddklkntttslf.ndenggyqytgkmfinnrradvsgdpkeytievlpegnsds.vicqvhh..hapwkhlqqp

QDGKLVIDMLKHIaRAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
     .| |.. .  ...|  |  . |    |.||. .|     |....      .... ..|.. |||  |..  ||   | .|  ..
pktlpiikmihqf.lsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

subfamily_hpo-7_pd Subfamily hpo-7 387-569 2.5e-12 41.3 In-house 43-227 (263) alignment
Range on Protein: 387-569
Range on HMM: 43-227/263.0
LETTINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKS--SEVRNVFHFQYEDWPEDGVPQDGK
|  ||. |....   .. .||||    |. ... ..           |  |.| . . |.  ... |.. .| .   ....| |..|  |.|   |.. .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

LVIDMLKhIARAQQqtgngPITVHCSDGSGRTGTFCAISIALER--VKLDA----TIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
 .. .|| .||  .     .. |||| | ||.  |  . ..  .    ||      .|  . ...|| .|.  ..|| |  |   .|  ||
eilnilk.varnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 390-569 3.4e-14 47.6 In-house 40-221 (255) alignment
Range on Protein: 390-569
Range on HMM: 40-221/255.0
TINDFWRMLWEYESYTVVMLNKDSENIKVRLKQTPDKGEFVVYGLLMVEVESEERQEGYIKRQLKISNTKS--SEVRNVFHFQYEDWPEDGVPQDGKLVI
|.. |....   .. .||||    |. ... ..           |  |.| . .     . | |.|  | .   . ..| |..|. |.|   |.. . . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DMLKHIARAQqqtgngPITVHCSDGSGRTGTFCAISIALERV--KLD----ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
 .|| .  ..      .. |||| | ||. .|  . ..  ..   ||    . .|  . ...|| .|.  ..|| |  |.  .|  .|
nilkvvrdsk......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

0048076 (Phosphotyrosine protein) phosphatases II 437-567 7.3e-26 86.0 In-house 18-141 (145) alignment
Range on Protein: 437-567
Range on HMM: 18-141/145.0
VEVESEERQEGYIKRQLKISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQtgNGPITVHCSDGSGRTGTFCAISIALErvkldATID
. .. |. ..  |.. | ...... ..|......| .||  |||.. .|....|. | .|...  .||. |||| | |||||..|. . |.       ..
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll.....lgvs

MFQTVRNLRTQRPIMVQTPEQYKFCYEVVRH
...... .|.|||..|..|.|..|.||....
leealelvrsqrpgavpnpgqlrflyefele

Y_phosphatase3 Tyrosine phosphatase family 442-532 2.7e-06 22.5 Pfam-A 76-154 (164) alignment
Range on Protein: 442-532
Range on HMM: 76-154/164.0
EERQegyIKRQLKISNTKSSEVRNVFHFQYEDWPEDGvpqdGKLVIDMLKHIARaqqqTGnGPITVHCSDGSGRTGTFCAISIALERVKLD
||..    ...|. . ....| .. ..  |.. .||      | . ..|...|.    .  ||. .||. |  ||| ..|.  .|  |. .
eeae...speelaerlkeaeeaeeamaeayreilede....kkayrkvlealae....ee.gpvlfHCtaGKDRTGvvaalllsllgvdee

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 455-566 7.4e-25 82.2 In-house 80-191 (440) alignment
Range on Protein: 455-566
Range on HMM: 80-191/440.0
ISNTKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQT
 |  .. | | . ...|. ||. |||.    |. |.. .  .|...||||. |||| |.||||   |.   |  .|    ||.|  . ..| .|| ||||
asyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqt

PEQYKFCYEVVR
|||| | .|.| 
peqyafvheavl

0048179 (Phosphotyrosine protein) phosphatases II 458-563 1.8e-23 78.3 In-house 41-139 (144) alignment
Range on Protein: 458-563
Range on HMM: 41-139/144.0
TKSSEVRNVFHFQYEDWPEDGVPQDGKLVIDMLKHIARAQQqtGNGPITVHCSDGSGRTGTFCAISIALervklDATIDMFQTVRNLRTQRPIMVQTPEQ
 . .. |....... .||  |||.. .|....|. | .|..   .||. |||| | |||||..|. . .        ........ .|..||..|..|.|
epefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgq

YKFCYE
..|..|
lrfLle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 461-568 2.1e-15 51.3 In-house 212-343 (350) alignment
Range on Protein: 461-568
Range on HMM: 212-343/350.0
SEVRNVFHFQYEDWPEDGVPQDGKLVIDMLK--------HIARAQQQTGNG-PITVHCSDGSGRTGTFCAISIALE-----------RVKLDA---TID-
|.   |...|.. |.. ..  . . .. .|.         .|.   .. .. || |||| | |||||....   |.            .|||    | | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

MFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHF
....| .|| ||  |||. .|. |.|| ....
isiivnelrkqrismvqnldqfifiYeallfy

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 465-568 8.7e-10 32.4 In-house 219-343 (349) alignment
Range on Protein: 465-568
Range on HMM: 219-343/349.0
NVFHFQYEDWPEDGVPQDGKLVIDML---KH-----IARAQQQTGN-GPITVHCSDGSGRTGTFCAISIALE--------RVKLDA---TID-MFQTVRN
 .. .|. .|.. ..  . . ..  |   ..      ||   .| .  .. |||| | ||||... . . |.         .|..    . | .. .| .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRTQRPIMVQTPEQYKFCYEVVRHF
|| ||  |||   |. ..|| . ..
lrkqrismvqnlaqfiaiyealLky

subfamily_PTPDC1_pd Subfamily PTPDC1 465-568 9.6e-10 33.2 In-house 82-175 (182) alignment
Range on Protein: 465-568
Range on HMM: 82-175/182.0
NVFHFQYeDWPEDGVPQDgKLVIDMLKHIARAQQQtgnGPITVHCSDGSGRTGTFCAISIALERvkldaTIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
.......  |.. ||.   . ..|. | .| | |.   | ..|||  | ||||   |  .   .      ..  .... .| .||  .|| || ... | 
giyvynf.gwkDygvasl.eriLdivkvvafalqe...gkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvkef

VRHF
  . 
alfl

subfamily_PTEN_pd Subfamily PTEN 465-561 2.8e-06 22.5 In-house 81-172 (184) alignment
Range on Protein: 465-561
Range on HMM: 81-172/184.0
NVFHFQYEdwpeDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAiSIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFC
.| ... .    |  |   .|. .....| .  ..  .  . |||  | ||||.  . .  |.. .|. . .. .   . ||.    |. | | .. 
rvavypfd....DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvliv.ayllkslllekaeealelfaeaRtknkkgvtiPsqrRYv

PTPc_DSPc_SM00012 468-565 7.8e-34 111.4 In-house 4-103 (105) alignment
Range on Protein: 468-565
Range on HMM: 4-103/105.0
HFQYEDWPEDGVPQDGKLVIDMLKHIARAQQQTG-NGPITVHCSDGSGRTGTFCAISIALERVKLD-ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVV
|..| .||. |||.... ....|... . ... . ..|. ||||.| ||||||.|..|.|....    ..|.||.|. ||.||| |||| ||| |.|...
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral





0038934 (Phosphotyrosine protein) phosphatases II 469-567 5.1e-09 31.5 In-house 80-175 (194) alignment
Range on Protein: 469-567
Range on HMM: 80-175/194.0
FQYEDWP--EDGVPQDGKLVIDMLKHIARAQQQTGNGPITVHCSDGSGRTGTFCAISIAL-ERVKLDATIDMFQTVRnlrtqrPIMVQTPEQYKFCYEVV
..| ..|  .||.. . ... . |. . .  ..  .| . |||  | |||||..|  .    . .... |..|. .|      | .........  .. .
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR......pgaipnqdyleallkry

RH
..
ke

PTEN_1 476-562 1.2e-07 26.7 In-house 103-186 (196) alignment
Range on Protein: 476-562
Range on HMM: 103-186/196.0
EDGVPQDGKLVIDMLKHIARAQQQTG-NGPITVHCSDGSGRTG-TFCAISIALERVKLDATIDMFQTVR-NLRTQrpimvqTPEQYKFCY
||  ...   ..|..| .. . ..   .. . |||  | ||.|   .|  .....   | ......  | . . .      .|.| .. .
eDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapn......spsqerlle

subfamily_DSP23_pd Subfamily DSP23 487-563 1.1e-06 23.4 In-house 71-140 (148) alignment
Range on Protein: 487-563
Range on HMM: 71-140/148.0
IDMLKHIARAQQQtgNGPITVHCSDGSGRTGTFCAISIALERvKLDATidmfQTVRNLRTQRPIMVQTPEQYKFCYE
 .... .  |...  |  ..|||  | |||||. |  .  || || |.    ... ..| .||  |.| || |  ..
vefvrvveeaeek..neavsvhcllgrgrtgtmlacylvker.klaaa....eaiaevrrlrpgsvetveqeklvrd

subfamily_CDC14_pd Subfamily CDC14 490-562 8e-06 19.9 In-house 252-317 (328) alignment
Range on Protein: 490-562
Range on HMM: 252-317/328.0
LKHIARAQQQTgNGPITVHCSDGSGRTGTFCAISIaLERVKLDATidmfQTVRNLRTQRPIMVQTPEQyKFCY
.|.  .. ... .| |.|||  | |||||. |  . ... .. |.    ...  ||  || .| .| | ||..
vkkfleiaeka.eGaiavhCkaGLGrtGtLiacyl.mkhyrftaa....eaiawlricrPGsvigpqq.kfle

subfamily_CG42327_pd Subfamily CG42327 494-569 3.6e-18 60.3 In-house 239-315 (319) alignment
Range on Protein: 494-569
Range on HMM: 239-315/319.0
ARAQQQTGNGPITVHCSDGSGRTGTFCAISIALERVKLD-ATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVRHFV
.|. ..  .||..|||||| ||||.  |  ||.....    ..|. |.|  .| .|   |.| |||.| | |.  . 
srsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 501-566 1.3e-11 39.0 In-house 227-292 (297) alignment
Range on Protein: 501-566
Range on HMM: 227-292/297.0
GNGPITVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEVVR
 | .. |||| | ||.|      . |.... .   |.   .. || ||. .||| ||....|..| 
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 506-564 1.3e-14 48.3 In-house 2-60 (69) alignment
Range on Protein: 506-564
Range on HMM: 2-60/69.0
TVHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
 |||| |.|||||| || . . |.| .  .|.|  |. .|  ||.||    .| | .. 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 507-564 9.4e-15 48.7 In-house 2-59 (69) alignment
Range on Protein: 507-564
Range on HMM: 2-59/69.0
VHCSDGSGRTGTFCAISIALERVKLDATIDMFQTVRNLRTQRPIMVQTPEQYKFCYEV
|||| |.|||||| || . . |.| .  .|.|  |. .|  ||.||   ..| | .. 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda