Gene NvecPTP-sf5-3 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP064_AA protein Get Run
NvecP064_AA_1-154 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-189 3e-105 346.8 In-house 130-319 (319) alignment 
Range on Protein: 1-189
Range on HMM: 130-319/319.0
QVKCHKYWPEEN-EQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGR
.||..||||||| |.||..||||||.|||.|..|||..|.|.|...|||.||||..|.||||||||.||.||...||.|.|.|..|||||.|||||||||
kvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGR

TGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
||||||.|||.|..|||..|||.|.|||.|.|||.|||||.||.||..||||||..||||||||.||.||.|||||||.||.||||||||
tGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetglerefq
subfamily_PTPRD_pd Subfamily PTPRD 1-189 1.4e-97 322.7 In-house 130-317 (564) alignment 
Range on Protein: 1-189
Range on HMM: 130-317/564.0
QVKCHKYWPEE-NEQYGKIIVTLEEKEELADFEIRKFSLrKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWeGPQSGPITVHCSAGVGR
.|||||||||. .|.||...|||||.|||||.|||.|.| | ....|.|.|..|.|||||||.|||.||.||.....||...  |..|||.|||||||||
kvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGR

TGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
||||||||||.|.||||...|.|.||...|.|||.|||...||.|||.|.|||...|.||.|..||...|..|||....|.|||||.|||
TGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFq
subfamily_PTPRA_pd Subfamily PTPRA 1-188 9.4e-61 200.5 In-house 140-330 (330) alignment 
Range on Protein: 1-188
Range on HMM: 140-330/330.0
QVKCHKYWPEEN-EQYGKIIVTLEEKEELADFEIRKFSLRKLSNQM---ETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAG
. ||..|||.|    ||.| |..|....| |. .||| ...|....   ..|.|. |.||||||  ||  . |.|.. |.|..  .  ..|||.||||||
eekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl.nqqsagpivvhcsaG

VGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREF
|||||||||.||..|..| |...||.  |.|.|.||  |||   || ||. .|||   .||||..|  |  .| .| .|..||  .||| ||
vGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkigleeef
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-160 1.3e-58 193.6 In-house 138-297 (298) alignment 
Range on Protein: 1-160
Range on HMM: 138-297/298.0
QVKCHKYWPE-ENEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGR
..|.|||||. ..|.||.| |.| .||| ||...||. . | ... ..|.|... ||||||..|||.|| .|.. ..|| | .     |..|.|||||||
ktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgR

TGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
.||||.||...|..|.|. .||. .| ..|..|  .||  .||.||..| |||.. ...||
sGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-153 7.5e-48 158.0 In-house 123-276 (281) alignment 
Range on Protein: 1-153
Range on HMM: 123-276/281.0
QVKCHKYWPEEN--EQYGKIIVTLEEKEELADFEIRKFSLrkLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVG
..|||.|||..|   .||...|. ...|| | .  |||.|    .. ||| |... .|.|||| ||. .. |||| | |..  |  .  |. .|||||||
klkChrYWPddnselkygdvtvkstaeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvG

RTGTFIVIDAMMEQIKEE-NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
||||.| .| .......| . |||   |  .| .||.|||   ||.|.. |.|.|.
rtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN9_pd Subfamily PTPN9 1-152 4.3e-43 142.5 In-house 124-289 (297) alignment 
Range on Protein: 1-152
Range on HMM: 124-289/297.0
QVKCHKYWP---EENEQYGKIIVTLEEKEELADFEIRKFSLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRN-----------SWEGPQS
..|| .|||   |. ...|.. |.  | ||  |...|.. ...  .  |.| | || |.||||. ||. |. ||.. . ||.           .|.|. |
rlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghps

G-PITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
| || ||||||.||||||| .|  .....|.. .||   |...|.|| |..| | || | . |.|| 
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_PTPN3_pd Subfamily PTPN3 1-152 2.3e-39 130.0 In-house 123-274 (280) alignment 
Range on Protein: 1-152
Range on HMM: 123-274/280.0
QVKCHKYWPEENE--QYGKIIVTLEEKEELADFEIRKFSLRKlSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGpQSGPITVHCSAGVG
.||||.||||...  .||.. |..|...|   . .|.. |.. ... | |.. .. ...||||.||. .. .||| .|||.  .| .. |. ||||||.|
rvkChqyWPetedeleygefsvkcekedetksyvlrelvlkd.ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg.keePvvvhCsaGig

RTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
||| .|...  .  | ... . .   |...| ||  .|| .||| |.  |.|..
rtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN13_pd Subfamily PTPN13 1-153 2.8e-39 130.0 In-house 116-269 (273) alignment 
Range on Protein: 1-153
Range on HMM: 116-269/273.0
QVKCHKYWPEENEQ----YGKIIVTLEEKEELADFEIRKFSLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgpQSGPITVHCSAG
.||||.||||....    .... |.|.. ..| .| .|.. .... .  |.| | |. |..||||.||  |. ||.| ..||.  .  ..||| ||||||
kvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds.esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPivvhcsaG

VGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
.||.||.|.||.... |. .. .||   | ..| ||. .||   || |.. |.||..
iGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-154 6.2e-38 125.3 In-house 130-284 (290) alignment 
Range on Protein: 1-154
Range on HMM: 130-284/290.0
QVKCHKYWPEE-NEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHD-VPEYATGLLEFWKRVRNSWEGPqSGPITVHCSAGVG
.|||..|||.. ...||.. ..| . |.| .. .||..... ... ....|... .|.|.... |....| || . ..... .     ..| ||||..||
kvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.ntsivvHCSdtvg

RTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
|...|....  ... | |   ||.. . . | |.  .||   || .|.. .|....
rsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_PTPN1_pd Subfamily PTPN1 1-161 4.4e-34 112.5 In-house 110-281 (290) alignment 
Range on Protein: 1-161
Range on HMM: 110-281/290.0
QVKCHKYWPEENE----QYG--KIIVTLEEKEELADFEIRKFSLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWE-GPQSGPITVHC
|.||..|||...|    ..   |. |.| ..|.   . .|.. | .|. | ||| . ||..|.|||  |||  . .|.|  .||.|    .. ||  .||
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktq.etreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihc

SAGVGRTGTFIVIDAMMEQI---KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTF--GDTEIE
|||.||.|||...|... .|   .. . .|.   .  .| .|  ..| . |  | . |.|| . .  ||. ..
saGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1-151 2.8e-25 84.0 In-house 121-275 (307) alignment 
Range on Protein: 1-151
Range on HMM: 121-275/307.0
QVKCHKYWPEENEQ---YGKI-----IVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegpQSGPITVH
..||..||| |. |   .|.      .  |  |.   | .. . .  |.    ..| ..|. .. |||. ||.   . ... . ||      .  |. ||
kikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.....dtnpvvvh

CSAGVGRTGTFIVIDAMMEQ-IKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
|||||||.|| . |  .... |. .|  |.   |  .|.||.. .|   || ..|  |||
csaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-189 4.4e-64 211.5 In-house 129-316 (318) alignment 
Range on Protein: 2-189
Range on HMM: 129-316/318.0
VKCHKYWPEEN-EQYGKIIVTLEEKEELADFEIRKFSLRKlSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRT
.|.|.|||... ..|||. |.|.|. ||.|. .|.|.... ... |.|.|. . .|||||..||| ...||.. ..|..  . .. |||.||||||||||
akvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrt

GTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
|.||..|...|.||.|.|.||. .|...| ||| |||  .|| ||. .||||.. ||||.. ..|| |. .| |. . .|.| .. |||
GvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq
subfamily_PTPRK_pd Subfamily PTPRK 2-189 3.6e-57 188.6 In-house 126-313 (314) alignment 
Range on Protein: 2-189
Range on HMM: 126-313/314.0
VKCHKYWPEENEQYGKIIVTLEEKEELADFEIRKFSLRKL-SNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRnSWEGPQSGPITVHCSAGVGRT
||| |||||. |.||.| |.| | | ||.. .| |...||  .| |.|.|..| |..||||||| .|||||.. .||  ... .. |.| |||||| |||
vkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvk.ksqeeeaGrivvhCsaGaGrt

GTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
||||.|| ... |..|...||.  |  .|...  ||.   || ||. ..|||.  |.| | | ...   ..  .  . |  . |. |||
Gtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefq
0040438 (Phosphotyrosine protein) phosphatases II 2-189 5.3e-56 185.5 In-house 126-312 (317) alignment 
Range on Protein: 2-189
Range on HMM: 126-312/317.0
VKCHKYWP-EENEQYGKIIVTLEEKEELADFEIRKFSLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGVGRT
.||..||| .|  .||...||| . ||||....|.. . .| .  |.|.|.||..|.||||.||.. . ||.| ..||.. | ...||. ||||||||||
ekcaqYwplgetltygdftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRt

GTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
||||... |.||...|. .||.. | ..|.||. .|| |.|| |...|||| .....| .....| ..|..| ...|...... |.|..
GtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkekelk
subfamily_PTPRB_pd Subfamily PTPRB 2-154 1.6e-55 183.3 In-house 134-286 (293) alignment 
Range on Protein: 2-154
Range on HMM: 134-286/293.0
VKCHKYWPEE--NEQYGKIIVTLEEKEELADFEIRKFSLRKlsnQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSW-EGPQSGPITVHCSAGVG
|||..|||..  . .||.| ||| ..||| |. ||.....|   ..|.| |... |||||||.||| .. ||.|...||..  .  ...||.||||||||
vkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvG

RTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
|||||| .| ....|.||...|... |...| .||..||  .|| ||| ..|. ..
RtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
0050432 (Phosphotyrosine protein) phosphatases II 2-157 3e-55 183.1 In-house 148-303 (308) alignment 
Range on Protein: 2-157
Range on HMM: 148-303/308.0
VKCHKYWPEE----NEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWegpQSGPITVHCSAGV
.||..|||.|     ..|||. ||| . |.|.|. .|.. |..|... |.|.|.||..|.||||.||.... ||.|...||.|    ..||| |||||||
ekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGv

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGD
|||||||..| ..||...|. .||...| ..| ||..||| |.|| |...|||| . .  
GRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0046845 (Phosphotyrosine protein) phosphatases II 2-160 4.3e-54 179.2 In-house 117-281 (284) alignment 
Range on Protein: 2-160
Range on HMM: 117-281/284.0
VKCHKYWPEEN--EQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG-PQSGPITVHCSAGVG
.||..|||.|.   .||...||| ..|.  |. .|...|..|.   |.|.|.||..||||||.||.... ||||.. ||.. |  |..||| ||||||||
ekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

RTGTFIVIDAMMEQIKEEN---LLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
||||||..| ..||...|.    .||...|.|.| ||..||| ..|| |...||||.. .. | .
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
0051299 (Phosphotyrosine protein) phosphatases II 2-153 1.1e-53 178.0 In-house 132-286 (288) alignment 
Range on Protein: 2-153
Range on HMM: 132-286/288.0
VKCHKYWP-EENEQYGKIIVTLEEKEELADFEIRKFSLRKLS---NQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGV
.||..||| .. ..||.| ||| . |.|.|. .|.. ...|.    . |.|.|.||..|.||||.||.... ||.|...||.. . ...||. |||||||
ekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGv

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|||||||..| ..||...|. .||...| |.| ||..||| |.|| |...||||..
gRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 2-168 2.5e-52 173.4 In-house 118-292 (297) alignment 
Range on Protein: 2-168
Range on HMM: 118-292/297.0
VKCHKYWP---EENEQYGKIIVTLEEKEE--LADFEIRKFSLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSA
.||..|||   .|  .||...||| . |.  |.|. .|.. . .. |. |.|.|.||..|.||||.|||... ||.|...||.  .   ..||. |||||
ekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsa

GVGRTGTFIVIDAMMEQIK---EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMR
||||.||||..| |..|..   .|. .|....|  .| ||...|| ..|| |...|||| . ...| .....| ..
GvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll
0047943 (Phosphotyrosine protein) phosphatases II 2-152 8.2e-51 168.4 In-house 117-271 (273) alignment 
Range on Protein: 2-152
Range on HMM: 117-271/273.0
VKCHKYWPEE----NEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMeTRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSAG
.||..|||.|     ..|||..||| . |. .|. .|.. |..|...  .|.|.||..|.||||.||.. . ||||.. ||.  |   ..||. ||||||
ekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaG

VGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
||||||||..| ...|...|. .||...| ..| ||  ||| |.|| |...|||| 
vgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-188 1.2e-50 167.3 In-house 132-314 (315) alignment 
Range on Protein: 2-188
Range on HMM: 132-314/315.0
VKCHKYWPEENEQYGKIIVTLEEKEELADFEIRKFSLRKLSNqmeTRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNsWEGPQSGPITVHCSAGVGRTG
 |. ||||...  |||| ||. ..|   .. .| .|    .|    | |  . .||||| .||.|.. |... ..|.  ..  . |.| |||||||||||
rkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfgdn...irevvqlhytswpdmgvpkytiplmnlirtvkq.hhtnsvgaivvhcsaGvGrtG

TFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEvQNLRMRLMQ-LAEKVAGTGMTGLEREF
||| .||...|.. ||..||| .. ..|..|  |||   || ||. ||||..  ||| |  |.| .   . |      || | |. .|
tfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsia.qdlylqrydsllapspdtgstllqeqf
0045450 (Phosphotyrosine protein) phosphatases II 2-152 1.6e-49 164.7 In-house 147-303 (307) alignment 
Range on Protein: 2-152
Range on HMM: 147-303/307.0
VKCHKYWPEENE--QYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSAGVG
.||..|||.|.|  .||.. ||| ..|.|... .|.. .  |.   |.|.|.||..|.||||.||..   ||.|...||.  |   ..||. ||||||||
ekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvg

RTGTFIVIDAMMEQIKEENL---LDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
||||||... |..|...|.    .|... |...|.||  .|| |.|| |...|||| 
RtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 2-151 5.3e-49 162.5 In-house 128-275 (278) alignment 
Range on Protein: 2-151
Range on HMM: 128-275/278.0
VKCHKYWPEENEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMEtRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGVGRTG
|||..|||.. ..||.. ||| . |.|.|. .|.. . .| .  . |.| |.....||||.|||  . ||.| |.||.  | ...||. |||||||||||
vkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTG

TFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
|||... ..||.. |  .|... |...| ||  .|| |||| |...||||
tfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 2-151 5.7e-49 162.0 Pfam-A 82-235 (235) alignment 
Range on Protein: 2-151
Range on HMM: 82-235/235.0
VKCHKYWP---EENEQYGKIIVTLE--EKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWeGPQSGPITVHCSAG
.||..|||   || ..||.| |.|.  |||. ... .||..|.|  .. |.|.||.. .|.||||.||| ...||.. ..|..|   ..|||..||||||
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaG

VGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
|||||||...|...||...|. .||...|...|.||. |||. .|| |.. |.||
vgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2-152 5.7e-49 161.7 In-house 130-278 (288) alignment 
Range on Protein: 2-152
Range on HMM: 130-278/288.0
VKCHKYWPEENE--QYGKIIVTLEEKEELADFEIRKFSLRklsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqSGPITVHCSAGVGR
 ||..|||....  .||.. ||| |..|| ||  ||. |     ... . .... ...||||.||| .. |||. . | .. .   .|||.|||||||||
tkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.tgpiivhCsaGvGr

TGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
|||||..||......||. .|| . |...| ||...||  .|| ||. .||. 
tgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
Y_phosphatase Protein-tyrosine phosphatase 2-151 5.7e-49 162.0 In-house 82-235 (235) alignment 
Range on Protein: 2-151
Range on HMM: 82-235/235.0
VKCHKYWP---EENEQYGKIIVTLE--EKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWeGPQSGPITVHCSAG
.||..|||   || ..||.| |.|.  |||. ... .||..|.|  .. |.|.||.. .|.||||.||| ...||.. ..|..|   ..|||..||||||
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaG

VGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
|||||||...|...||...|. .||...|...|.||. |||. .|| |.. |.||
vgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2-151 3.4e-47 155.7 In-house 85-237 (237) alignment 
Range on Protein: 2-151
Range on HMM: 85-237/237.0
VKCHKYWPEEN--EQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG-PQSGPITVHCSAGVG
.|||||||. .  . ||.. |.|  |||..|. .| . | |  .. | |... . ||||||. ||.... || | |.. |  .  ..|||  .|||||||
lkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvg

RTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
||| |.|||||. | ||....|.| ||  |  .| ...|   || ||| ..||
rtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0045098 (Phosphotyrosine protein) phosphatases II 2-153 6.3e-47 155.6 In-house 104-272 (278) alignment 
Range on Protein: 2-153
Range on HMM: 104-272/278.0
VKCHKYWPEEN-EQYGKIIVTLEEKEELADFEIRKFSLRKL---SNQMETRMVKHFYFTSWPDHDVPEYA--TGLLEFWKRVRNSWE------------G
.||..||||.. ..||.. |||.. |.| |. .|.. .. |    .  |.| |.|.....||||.||..   . .||.....|.  .             
ekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

PQSGPITVHCSAGVGRTGTFIVIDAMMEQIkeENLLDVYSYVSRIRAQRNF-MVQRPSQYSFIHYALLEAV
...||. ||||||||||||..... |.|..  |. .|....|. .| ||.. .|| ..|| |....||| .
dsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
DSPc_SM00195 2-153 7.9e-47 155.2 In-house 109-262 (263) alignment 
Range on Protein: 2-153
Range on HMM: 109-262/263.0
VKCHKYWPEE---NEQYGKIIVTLEEKEELA-DFEIRKFSLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqSGPITVHCSAGV
 ||..|||||   .|..||| |.| |.|.   ....|...|.|  .  ||| |... ...||||.||. .. .||. . |..| .   |||| |||||||
ekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGv

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
||||||..|| ......||. .|. . |...| ||  |||   ||.||. |.||..
gRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2-153 7.9e-47 155.2 In-house 109-262 (263) alignment 
Range on Protein: 2-153
Range on HMM: 109-262/263.0
VKCHKYWPEE---NEQYGKIIVTLEEKEELA-DFEIRKFSLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqSGPITVHCSAGV
 ||..|||||   .|..||| |.| |.|.   ....|...|.|  .  ||| |... ...||||.||. .. .||. . |..| .   |||| |||||||
ekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGv

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
||||||..|| ......||. .|. . |...| ||  |||   ||.||. |.||..
gRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0037934 (Phosphotyrosine protein) phosphatases II 2-151 1.2e-46 154.6 In-house 88-240 (243) alignment 
Range on Protein: 2-151
Range on HMM: 88-240/243.0
VKCHKYWPeENEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG-------PQSGPITVHCS
.||..||| ....||...||| . |.|.|. .|...|. |. . .||.| |.....||||.||.  . ||.|.. ||.  |        ...||. ||||
ekcaqywp.gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

AGVGRTGTFIVIDAMMEQIkeeNlLDVYSYVSRIRAQRNF-MVQRPSQYSFIHYALLE
||||||||.|... |....   . .|....| ..|.||.. .|| |||| |...||||
aGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
0040439 (Phosphotyrosine protein) phosphatases II 2-152 2.7e-46 153.6 In-house 94-245 (249) alignment 
Range on Protein: 2-152
Range on HMM: 94-245/249.0
VKCHKYWP-EENEQYGKIIVTLEEKEELADFEIRKFSLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSAGVGR
.||..||| ..  .||.. ||| . |...|. .|.. | .|    |.|.|.|...|.||||.||..   ||.|...||.  |   ..||. |||||||||
ekcaqywplggsleygdftvtllsvevkddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgR

TGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
|||||... |.||...|. .|....|. .| ||. .|| |.|| |...|||| 
tGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 2-151 3.2e-45 149.8 In-house 92-241 (245) alignment 
Range on Protein: 2-151
Range on HMM: 92-241/245.0
VKCHKYWP-EENEQYGKIIVTLEEKEELADFEIRKFSLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRT
|||..||| .|  .||...||| . | |.|. .|.... .|    |.|.| |.....||||.||..   ||.| ..||.  . ...||. ||||||||||
vkcaqywplgesltygdftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt

GTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
||||... |.||...|  ..... | ..| ||  .|| |||| |...||||
GtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-189 4.6e-43 142.3 In-house 127-313 (315) alignment 
Range on Protein: 2-189
Range on HMM: 127-313/315.0
VKCHKYWPE---ENEQYGKIIVTLEEKEELADFEIRKFSLRKlsnQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAGVG
.|| .|||.   .  ..|.| |.| . |  .|  .||. .||     |.| |  | || |||. |.. .. ||.. | |. . .|..  .. ||||||||
ikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrk...seesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvG

RTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
||| .| || ...|||... .||. .|  .||.| ..||   .|.||. |.|| . . .| | | ..  .| .|   | |.| . . .||.
rtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefe
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2-151 2.7e-42 139.7 In-house 113-266 (274) alignment 
Range on Protein: 2-151
Range on HMM: 113-266/274.0
VKCHKYWPEENEQ-----YGKIIVTLEEKEELADFEIRKFSLRKLSNqmeTRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP--QSGPITVHCS
 ||..|.|....      ||.. .. |.. |  |...||..|..|..   .| |||...|.||||..|. |. ||.. . |..| |    . .|. ||||
qkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCs

AGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
||.|||| || |.  . |..||. .|| . |. .| .|  |||  .|| .|| || .
aGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPN12_pd Subfamily PTPN12 2-153 3.8e-42 139.1 In-house 123-277 (290) alignment 
Range on Protein: 2-153
Range on HMM: 123-277/290.0
VKCHKYWPEE---NEQYGKIIVTLEEKEELA-DFEIRKFslrKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGV
 ||..|||||   . ..|.. |||||.. .  || || .   |. .| |.|.|. | .|.||||.||. |. |||. . ||.  |  .. |. |||||||
kkCerYWpeegeeelefgefevtleeekavdddflirtL...kveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGv

GRTGTFIVIDAMMEQIKEENL---LDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
||||| |.|| . |..|.|..   |||.. | ..| ||. .||   ||.... |..| |
GrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2-167 1.5e-41 137.3 In-house 126-293 (439) alignment 
Range on Protein: 2-167
Range on HMM: 126-293/439.0
VKCHKYWPEENEQY-GKIIVTLEEKEELADFEIRKFSLR-KLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGR
|. .|||| ..| . | |.|  . . || .. || | .  .  .    | | .|....|||..||  |. .|.| . .  . .  . ||. |||||||||
vesykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGr

TGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRM
||| | .|  .||.| || .|.   |. .| ||. |||   || ||. |.|| . .||. . ..... 
tGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2-189 1.4e-40 133.8 In-house 126-312 (515) alignment 
Range on Protein: 2-189
Range on HMM: 126-312/515.0
VKCHKYWPE---ENEQYGKIIVTLEEKEELADFEIRKFSLRKLSNqmeTRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWeGPQSGPITVHCSAGVG
.|| ||||.   .  ..|.| | |   |  ..  .||. . | ..   .| |  | || |||. ||. .. || . | |. .  |  . |. .|||||||
ikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadh.gqythpliihcsaGvG

RTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
||| .| || .. ..|. . .||. .|  ||..| ..||   ||.||. |.|| . . .| | |  .   | .|     | | . . .|||
rtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-160 5.2e-39 128.9 In-house 126-285 (287) alignment 
Range on Protein: 2-160
Range on HMM: 126-285/287.0
VKCHKYWPEEN-EQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHD-VPEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGVGR
 .|..|||||.   .|.  ..| ..|  |.. .||. ... ... ....|| . .|.|...  |.|..| || . .....    .  ..| ||||..|||
evcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrk.rgntsivvhCsdtvGr

TGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
...|. ..  ... |.|  .||.. . . | |.  .||  .|| ||  ..|| .. ..|  
samfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
0051429 (Phosphotyrosine protein) phosphatases II 2-161 5.1e-37 123.4 In-house 61-232 (272) alignment 
Range on Protein: 2-161
Range on HMM: 61-232/272.0
VKCHKYWP-------------EENEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYAtgLLEFWKRVRNswegpqSGP
.||..|||             ..   ||.. ||| ..| | |. .|.. |..|..  |.|.| |...|.|||| ||. |  |||. . ...      .||
lkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggp

ITVHCSAGVGRTGTFIVIDAMMEQIKEENLLD--------VYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAvTFGDTEIE
. ||||||..||||..... ..... .|  .|        .. .|...||||  .|| . || |.. ||||.   . ....
vlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel.lrsllsvr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2-152 1.3e-35 117.7 In-house 104-263 (270) alignment 
Range on Protein: 2-152
Range on HMM: 104-263/270.0
VKCHKYWPEENEQ-----YGKIIVTLEEKEELADFEIRKFSLRklsNQMETRMVKHFYFTSWPDHDVPEYAT------GLLEFWKRVRNSWEGPQS-GPI
 || .|||.|...     .||| |. ...|    . ...  |.   .. |.| . ||....|||| ||. .        ||.  . ||.| .  .  .|.
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePl

TVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
 ||||||||||||.|..| ... ..|.. .|| . ....| .|  .|| | || |.. |..| 
lvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
0036282 (Phosphotyrosine protein) phosphatases II 2-147 2.9e-35 116.9 In-house 52-164 (174) alignment 
Range on Protein: 2-147
Range on HMM: 52-164/174.0
VKCHKYWPEeneqygkiivtleekeeladfeirkfslrklSNQMETRMVKHFYFTSWPDHDVPEYATgLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTG
.||. ||||                                 . ..|.. ..... |||| ||. .. |||| |.|..  . ...||. |||||||||||
ykcinywpe...............................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtG

TFIVIDAMMEQIKeENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHY
|..... |. ... |.| |....| ..| ||  |||.|||| |..|
tlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPN23_pd Subfamily PTPN23 2-153 1.6e-33 110.8 In-house 123-280 (288) alignment 
Range on Protein: 2-153
Range on HMM: 123-280/288.0
VKCHKYWPEENE---QYGKIIVTLEEKEELADFEIRKFSLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRN---SWEGPQSGPITVHCSA
 |...||||...   ..|.. |||....|.  .  |...|. | .. ....|.|  .||||.. ||.    ||.| . |..   . . .   |. |||||
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl.dadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsa

GVGRTGTFIVIDAMMEQIKEEN-LLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
||||||.| .. | .......| |||.   |||.|.|| ||||  .|. |   | |||.
GvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-165 2.6e-33 110.2 In-house 115-278 (283) alignment 
Range on Protein: 2-165
Range on HMM: 115-278/283.0
VKCHKYWPEE-NEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqSGPITVHCSAGVGRT
.|| .|||..  |.||.  |||..      | |... ||. |   .| .. |. .  | . .       |. | | . .  | .  ||| ||||.|.|||
ikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk.kgPivvhCstgiGrt

GTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNL
..|| . | ..... | ..||.. |  .| ||  .||   || ..| . ||    |||.|   .|
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl
subfamily_PTPN14_pd Subfamily PTPN14 2-151 9.6e-30 98.6 In-house 133-294 (300) alignment 
Range on Protein: 2-151
Range on HMM: 133-294/300.0
VKCHKYWPEE-----NEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRV---RNSWEGP-----QSGP
 |..||.|..     . ..||  || . .|.   .  ... |. |  . | | | |. .| ||||.|||  .| |.. ..|   |.  .       .. |
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk.eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

ITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
. |||||||||||  |. | ... .. .. .|. . ..|.| || ..||  .|| |.. .|..
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-158 2.6e-26 87.0 In-house 125-298 (301) alignment 
Range on Protein: 2-158
Range on HMM: 125-298/301.0
VKCHKYWPE---ENEQYGKIIVTLEEKEELADFEIRKFS--LRKLSN------------QMETRMVKHFYFTSWPDHDV-PEYATGLLEFWKRVRNSWEg
 ||..|||.   |.|..|.. ||| ..  . || ||...  ... ||            ..... |  .  |.||.. | .|..| |    . .   .  
skceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqk.

PQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDT
.  ||. ||||..|.|.|... ..  .|| | |   ||.  . ..| ..  .|.   ||..|. .. . ... .|
igggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2-150 6e-26 85.9 In-house 120-274 (287) alignment 
Range on Protein: 2-150
Range on HMM: 120-274/287.0
VKCHKYWPEENEQ---YGKIIVTLEEKEELADFEIRKFSLRKLSNqMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRV----RNSWEGPQSGPITVHCS
 ||.||||| .      |  .| |. .    .. .| . | .|    |.|.|| . . ||||. ..  | ||. |   |      . .. . ||. ||..
lkcykywPerevPmrvGGysvvlldydikePeygvralrlidlet.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhdd

AGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
.|.||.|... . ..... ..   .||   | |.| .|. .|| . |. ..  || 
vGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0044763 (Phosphotyrosine protein) phosphatases II 2-151 2.7e-25 84.5 In-house 64-169 (178) alignment 
Range on Protein: 2-151
Range on HMM: 64-169/178.0
VKCHKYWPEENEqygkiivtleekeeladfeirkfslrklsnqmetrmvKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgPQSGPITVHCSAGVGRTG
.||..|||||..                                      ..... .|||.||.    .||| . ...  . .. ||. |||||||||.|
lkcdpywpeeag.....................................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsg

TFIVIDAMMEQikeeNLlDVYSYVSRIRAQRNfMVQRPSQYSFIHYALLE
|..... |...    .| .... ....|..|. .|..|.|. ....  |.
tlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2-151 1.1e-23 78.3 In-house 134-281 (290) alignment 
Range on Protein: 2-151
Range on HMM: 134-281/290.0
VKCHKYWPEENEQ---YGKIIVTLEEK-EELADFEIRKFSLRKLSNQMEtRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGV
 ||..|.||.. .   .|.| |.  |. .. |.   . .|.|.  .  |  ..||.   ||||. |.  .  ||   . .|.      |||..||||||.
akceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGke.hklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGi

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
||||||. |.. .. . .   ||.   |  .|  |   ||   ||  .  .||.
GrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2-151 8.5e-22 72.1 In-house 136-287 (305) alignment 
Range on Protein: 2-151
Range on HMM: 136-287/305.0
VKCHKYWPEE----NEQYGKIIVT-L-EEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSA
.|| .|||       |  . |.|  .   |    | ||.   |.   .  ..  |.|. .| |||  ||      ||.   .| |       || |||||
lkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs.....kvpivvhcsa

GVGRTGTFIVIDAMMEQIKEENLL-DVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
|.||||| . |. ..|.| |..    .   |  .| || | .|   || |||  .|.
gigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2-168 5.2e-20 66.6 In-house 68-235 (255) alignment 
Range on Protein: 2-168
Range on HMM: 68-235/255.0
VKCHKYWPEENEQYGKII-VTLEEKEELADFEIRKFSL-RKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEgpqsgPITVHCSAGVGR
.||..|.| | ..  |.  |..   .  ||  .|   .  .|... .|. |||. .. |...  || |  .|. .| ||.|       .. ||||.|.||
ekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvrds.k.....svvvhCstGiGr

TGTFIVIDAM----MEQIKE--ENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVtFGDTEIEVQNLRMR
. .|.... .    . ....     ||  | .  .| .|.  .. | | .|  . .|. | |  .|.| .  ..|
saafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.fpkgeleakyqeir
subfamily_hpo-7_pd Subfamily hpo-7 2-166 1.3e-15 52.0 In-house 74-244 (263) alignment 
Range on Protein: 2-166
Range on HMM: 74-244/263.0
VKCHKYWPEENEQYGKII-VTLEEKEELADFEIRKFSLRK-LSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEgpqsgPITVHCSAGVGR
.|| .|.| | ..  |.  |..   .   |  ..   | . |... .|. |||. .. |...  || |   |.  | .|||       .. ||||.|.||
ekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarns.k.....slvvhcstGiGr

TGTFIVIDA----MMEQIKEE--NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG--DTEIE--VQNLR
.  | |..     |. ....     ||  | .  .| .|.  .. | | .|  . .|. |       |.|   |..|
saafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgeleakyqeir
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 3-172 2.9e-60 199.0 In-house 130-302 (305) alignment 
Range on Protein: 3-172
Range on HMM: 130-302/305.0
KCHKYWPEENEQ---YGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGR
||..||||.  .   .|...|.|..... .|. .||... . ... |.| | .. .|.|||| ||..|| ||.. |||.....  .  |..|||||||||
kCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgR

TGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQL
||.||..| ..|..|.|. .||. .. ..| .|  |||   || |.| || | .| |||.| ..|||.|. .|
tGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnkl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 3-154 3.3e-54 178.7 In-house 92-243 (250) alignment 
Range on Protein: 3-154
Range on HMM: 92-243/250.0
KCHKYWP-EENEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTG
..|.||| |. |.||.. |.| .||| ||...||. | | ... . |.|... |..|||  |||.||  ||. |.|. | .  ...|. |.|||||||.|
tyhqywPvekaekyGdvtvsllskeefadytkrklklskakka.derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG

TFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
.||.|||..|..|.|. .||. .. ..|..|  .|.  .||.|.. ..|.|..
afiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPRG_pd Subfamily PTPRG 3-166 7.4e-52 171.3 In-house 132-300 (563) alignment 
Range on Protein: 3-166
Range on HMM: 132-300/563.0
KCHKYWPEE-NEQYGKIIVTLEEKEELADFEIRKFSLRKL-----SNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAG
||. |||..  |.||.. |||.|.| ||   .|......|     ... . ..|... .|.||||.|||...  | | |.   . .  . |||.||||||
kcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa.nkaeaGPivvHcsaG

VGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLR
||||||.||.|....||..||  .|.  . .|||||||.||   || |.| |||||.. ..||.  ....
vgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve
subfamily_Ptp69D_pd Subfamily Ptp69D 3-171 1.8e-51 170.1 In-house 132-304 (307) alignment 
Range on Protein: 3-171
Range on HMM: 132-304/307.0
KCHKYWP-EENEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQM----ETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGpQSGPITVHCSAGV
||.|||| |.. |||.|.|.| ..|.  |. ||.... |  ..     ..| |  . .|.|.|  ||| |.|||.. ..||.  .  . .||.|||||||
kcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl.nrsPivvhCsaGv

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQ
||.|.|. .| ...|.|.|. .|..  |  .| |||..||.  ||.|.. |||.  ..|||...|..|  .. .
grsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaier
0039614 (Phosphotyrosine protein) phosphatases II 3-157 1.3e-50 167.9 In-house 141-293 (297) alignment 
Range on Protein: 3-157
Range on HMM: 141-293/297.0
KCHKYWPEENEQYGKIIVTLEEKEELADFEIRKFSLRKlsnQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSAGVGRTG
||..||||| ..||.. ||| . |.|... .|......     |.|.|.|| .|.||||.||.... |||| . ||.  .   ..||. |||||||||||
kcaqywpeeggtygdftvtllkvehldgytvrtlevtn...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtG

TFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGD
|||... |.||...|  .||.. |...| ||. .|| |||| |...|||| . ...
tfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 3-175 9.8e-47 154.8 In-house 139-313 (319) alignment 
Range on Protein: 3-175
Range on HMM: 139-313/319.0
KCHKYWPEE-NEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSAGVGRT
|| .||| . ......  | ..  || |.. .|.. | . ... . | .. |.|  |||. ||.|.. |. . |.||   .   .  .| ||||||||||
kcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

GTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEK
|..||.|......|||. .||| .|  .| ||| .||   || ||. ||||   || ... . ..   | .|..|
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnk
subfamily_PTPN6_pd Subfamily PTPN6 3-151 4.1e-46 152.4 In-house 139-295 (306) alignment 
Range on Protein: 3-151
Range on HMM: 139-295/306.0
KCHKYWPEEN--EQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQ---SGPITVHCSAGV
|| .|||.|.  |.|||| ||  ....|||...|..|. | ... |.| | .. |.|||||.||.    .|.|.. |..  |  .   .||| ||||||.
kCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGi

GRTGTFIVIDAMMEQIKEENL---LDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
||||||||||.....|... |   .|... |  .|.||. .||  .|| |...|. .
GRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 3-175 5.8e-46 152.3 In-house 103-277 (284) alignment 
Range on Protein: 3-175
Range on HMM: 103-277/284.0
KCHKYWPEE-NEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGP-QSGPITVHCSAGVGRT
|| .||| . ......  | ..  || ... .|.. | . ... . | .. |.|  |||. ||.|.. |. . |.||   .   .  .| ||||||||||
kcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEK
|..||.|......|||. .||| .|  .| ||| .||   || ||. ||||   || ... . ..   | .|..|
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 3-152 2.8e-44 146.0 In-house 92-239 (239) alignment 
Range on Protein: 3-152
Range on HMM: 92-239/239.0
KCHKYWPEENEQYGKIIVTLEEKEELADFEIRKFSLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGT
|||.|||.   .| .. ||| . | .||. || | . ..  | | | | ...|| |||. ||.||| .| . ... .    | . |  .||||||||||.
kchqywpdstskycnlrvtlrktevfadyiirtfvmsqv.gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtga

FIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
|.|||||. | |... .|.. ||  || .| .|||   || ||| |.|||
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 3-151 1.1e-43 144.1 In-house 93-239 (239) alignment 
Range on Protein: 3-151
Range on HMM: 93-239/239.0
KCHKYWPEENEQYGKIIVTLEEKEELADFEIRKFSLRKLsNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGRTGT
|||.|||.   .| .. ||| . | .||. || | . ..  | | | | ...|| |||. ||.||| .| . ... .    | . |  .||||||||||.
kchqywpdstskycnlrvtlrktevfadyiirtfvmsqv.gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.slpgarpwvihcsagvgrtga

FIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLE
|.|||||. | |... .|.. ||  || .| .|||   || ||| |.||
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-189 7.6e-43 141.9 In-house 131-324 (325) alignment 
Range on Protein: 3-189
Range on HMM: 131-324/325.0
KCHKYWPEE---NEQYGKIIVTLEEKEELADFEIRKFSLRKLSnQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG-----PQSGPITVHCS
.| .|||.|     ..| . | |   ||..|.  |.. ... . . ||| || | . ||.|  |... . |. . . | .  |        |.|| ||||
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

AGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
|||||||.|| . ...... ||  .|.. .| ..|..|  ||.   ||..|. || ||.  |.|.. | ..  .|  | |.   |    .|.||.
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekefe
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-163 1.2e-42 141.0 In-house 132-294 (297) alignment 
Range on Protein: 3-163
Range on HMM: 132-294/297.0
KCHKYWPEEN-EQYGKIIVTLEEKEELADFEIRKFSLRKlSNQMETRMVKHFYFTSWPDHDVPE--YATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGR
|| .||...   ..|.. |.|.  .|   |  |.....| ..   .|.|| . |..|||..|..   |. ||.. . ||..... ..||. |||.|||||
kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

TGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEIEVQ
|| .. || .. ..|.|. .|.. .|...| .| ..||   ||.|.. |.|||.   ||.|...
tgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_CG7180_pd Subfamily CG7180 3-154 4e-37 122.4 In-house 125-291 (296) alignment 
Range on Protein: 3-154
Range on HMM: 125-291/296.0
KCHKYWPEE-NEQYGKIIVTLEEKEELADFEIRKFSLRKL---------SNQMETRMVKHFYFTSWPD-HDVPEYATGLLEFWKRVRNSW----EGPQSG
....|||.. .||||.|.| . |....|...||.| | |            ..|||.||.| .| |.  . ||  ...|.|. .|||       | |. |
mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg

PITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVT
|. |..| |..|.| .. ||| .|....|. .||. .| ..| .|. .|.   .| .|   ||||| 
PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPRN_pd Subfamily PTPRN 3-153 2.1e-33 110.3 In-house 141-292 (297) alignment 
Range on Protein: 3-153
Range on HMM: 141-292/297.0
KCHKYWPEENE-QYGKIIVTL-EEKEELADFEIRKFSLRKLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGpQSGPITVHCSAGVGRT
.|..|||.| .  |.   | |  |.    |. .| | |. | .. ||| |  |.| |||...||  |  |||| ..|  |. | .| || ||||.|.|||
qckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqts.etrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrt

GTFIVIDAMMEQI-KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|..|.|| ..... |  . .|. . .  .| ||. .|.  .|. |.  |. | |
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
0046846 (Phosphotyrosine protein) phosphatases II 3-150 4.1e-28 93.7 In-house 64-170 (176) alignment 
Range on Protein: 3-150
Range on HMM: 64-170/176.0
KCHKYWPEENEQYGkiivtleekeeladfeirkfslrklsnqmetrmvkHFYFTSWPDHDVPEYaTGLLEFWKRVRNSWEGPqsGPITVHCSAGVGRTGT
||. ||||. .                                      ..... ||||.||.. . |||. . .|.  .    ||. ||||||.|||||
kcpnywpeleklgi...................................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgt

FIVIDAMMEqikeENLLDVYSYVSRIRAQRN-FMVQRPSQYSFIHYALL
..... ..     |. |.|.  ....|.||  ..|| |.|| |.....|
lvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefel
0051082 (Phosphotyrosine protein) phosphatases II 3-150 8.6e-26 85.7 In-house 48-150 (151) alignment 
Range on Protein: 3-150
Range on HMM: 48-150/151.0
KCHKYWPEENeqygkiivtleekeeladfeirkfslrklsnqmetRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegPQSGPITVHCSAGVGRTGT
.|..|.||..                                   . |.|.....|||...|..   .|||.. ...    ...||. ||||||.|||||
ycpeylpelg...................................ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGt

FIVIDAMMEQikeenlLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
..... |...      ..... .. .|..|  .|| . |. |...|||
lvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfall
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 3-153 2.3e-20 67.7 In-house 116-270 (285) alignment 
Range on Protein: 3-153
Range on HMM: 116-270/285.0
KCHKYWPEE---NEQYGKIIVTLEEKEELADFEIRKFSLRKL---SNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSweGPQSGPITVHCSAG
||  |.||.     ..||  .|| | .| |       .|  .       |   ..|     |||.  || |  ..|..| |..    |.  || ||||||
kcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv..npkekpicvhcsag

VGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAV
|||| ||. ||    .| |.  ...   |  .|| |   ||   |. |..  |.| .
vgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 3-145 1.8e-18 61.3 In-house 131-273 (301) alignment 
Range on Protein: 3-145
Range on HMM: 131-273/301.0
KCHKYWPEENE---QYGKIIVTLEEKEELADFEI--RKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGV
||..| | . .   . |.  .....|| . . .|  |.. ..  .....|| | |. ...|.|..||.  . | .. . |..|       || ||||||.
kceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsaGi

GRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFI
||. .||  . .  ... .. ...   . ..| .|   ||. ||  ..
Grsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 3-151 5.5e-18 59.6 In-house 122-267 (281) alignment 
Range on Protein: 3-151
Range on HMM: 122-267/281.0
KCHKYWPEENE---QYGKIIVTLEEKEELADFEIRKFslrKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegpQSGPITVHCSAGVGR
|| .|.| .     |. |. |. |.      .   ..   .|| . |||.. |. .  ||| .||| .  .|.  ...|      .| |  .||||||||
kcaeyfprnahcclqfdklsvsyedstvnkslvttrl...nlsyegetrlithwlwkewpdwqvpessevmlkilrkira.....rstppvihcsagvgr

TGTFIVIDAMMEQIKEE-NLLDVYSYVSRIRA-QRNFMVQRPSQYSFIHYALLE
.||.. ..  .. |.    | |.   ||..|   |   ||   || .|   ||.
sgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 3-175 7.6e-16 53.1 In-house 112-265 (290) alignment 
Range on Protein: 3-175
Range on HMM: 112-265/290.0
KCHKYWPEENE---QYGKIIVTLEEKEELADFEIRKFSLRkLSNQmETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGVGR
 | || ||. .   ... . |   .||.  |.|.|.  ..   .. |   |.|  . .| .  |.|    ||.  . |..|       |. |||  |. |
aCakYvpesvgeelkfkgltvkCkskekeddvetRelvvk.fdde.eeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSr

TGTFIVIDAMMEQIK-EENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLeavtfgdteievqnlrMRLMQLAEK
  ..  |.  .  |   .. . . . .. .| ||. ..... ...|. ....                .....  ..
sAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv................llaievldq
subfamily_ptpA1_pd Subfamily ptpA1 3-113 1.5e-13 45.3 In-house 130-256 (418) alignment 
Range on Protein: 3-113
Range on HMM: 130-256/418.0
KCHKYWPE------------ENEQYGKIIVTLEEKEELADFEIRKFSLRkLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEG--P---Q
|| .||||             || .|   | | |  .  . ||    .| |. . ||| . .. .  ||||..|...  . .. . . |  .   |   .
kcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnir.ltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdr

SGPITVHCSAGVGRTGTFIVIDAMMEQI
  || |||||||||||||     ||...
nvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 3-160 3.1e-11 37.4 In-house 135-296 (310) alignment 
Range on Protein: 3-160
Range on HMM: 135-296/310.0
KCHKYWPEE--NEQYGKIIVTlEEKEELADFEIRKFSLRKL---------SNQMETRMVKHFYFTSWPDHDVPEYATGLLEfwKRVRNSwegPQSGPITV
||  |||     | || | || .  |   .||| ....  .           ...   |.   .  |||  ||.     .   .|.       . ||  |
kcvgywpslgvtetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaq...vrhgpcvv

HCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLeAVTFGDTEI
|||||..|... . ..  ...... . .|.   .. .. .|   .| . || .|..  . . . |.||.
hcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetev
subfamily_CG42327_pd Subfamily CG42327 3-80 7.2e-09 29.7 In-house 113-193 (319) alignment 
Range on Protein: 3-80
Range on HMM: 113-193/319.0
KCHKYWPEE-----NEQYGKIIVTLEEKEELADFEIRKFSLRKLSnQMETRMVKHFYFtSWPDHDVPEYATGLLEFWKRVRNS
.| .|.| .     .. ||.| ||| ..|    . |  . |...  . |.| . |...  |.. .||   . |.    .||.|
vcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvd.keesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 3-73 5.6e-08 27.0 In-house 117-189 (297) alignment 
Range on Protein: 3-73
Range on HMM: 117-189/297.0
KCHKYWPEEN---EQYGKIIVTLEEKeELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEF
||  |||. .    . |...|    .    .|.  ...  .|  . |.|.|.|  | ||||| ||     |  |
kcapywpsvvqerlkagdvvveflss.tsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrf
subfamily_egg_pd Subfamily egg 3-154 6.6e-08 26.6 In-house 122-274 (307) alignment 
Range on Protein: 3-154
Range on HMM: 122-274/307.0
KCHKYWPEENEQ---Y--GKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMVKHFYFTSWPDHDVpeyaTGLLEFWKRVRNswegpQSGPITVHCSAGV
.|. |||  ...   .  | . ..  . .. ||   |   |. .  . | | ..|.        ||       |.  ...||      | |. |..  ||
rceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdv....ysplrvlrklrn.....lskpvvvqdilGv

GRTGTFIVID-AMMEQIKEEN-LLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL---EAVT
 ...|.. |. |... ..       |   |  .| .|.. |. . .| |..  .|     | 
skaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi
0041856 (Phosphotyrosine protein) phosphatases II 4-160 9.8e-33 108.6 In-house 67-178 (182) alignment 
Range on Protein: 4-160
Range on HMM: 67-178/182.0
CHKYWPeeneqygkiivtleekeeladfeirkfslrklsnQMETRMVKHFYFTSWPDHDVPEyATGLLEFWKRVRNswegpQSGPITVHCSAGVGRTGTF
.. |||                                  . ..|.. ......||||.||.    ||.| ..|..     ..||. ||||||||||||.
eelywp..................................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtl

IVIDAMMEQikeeNlLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTEI
.... |...    . ..... |. .| .|. ||..|.|| |...|||| . ...|..
vaaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
0043147 (Phosphotyrosine protein) phosphatases II 4-147 6.3e-31 102.8 In-house 33-155 (172) alignment 
Range on Protein: 4-147
Range on HMM: 33-155/172.0
CHKYWPEENEQYGKIIVTLEEKeeladfeirkfslrKLSNQMETRMVKHFYFTSWPDHDVPeYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTF
....|    |.  ..||.| |                .  . ..|.. ......||||.||  .  |||| . ...     ..||. ||||||||||||.
ladfwrmlkelgithivnltel..............lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

IVIDAMMeqikeeN-LlDVYSYVSRIRAQRNFMVQRPSQYSFIHY
.... |.        | ...  |. .|..|. .|| |||| |..|
vaaylml......lgl.sleeavalvrekRpgavqnpsqyrflyy
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 4-147 5.8e-09 29.9 In-house 150-296 (332) alignment 
Range on Protein: 4-147
Range on HMM: 150-296/332.0
CHKYWPEENEQYGKIIVTLEEKEELADFEIRKFSLRKLSNQMETRMV-KHFYftSWPDH-DVPEYATGLLEFWK--RVRNSW-EGPQSGPITVHCSAGVG
|.|.|||.. .     ....  .. ..  .. | |    .. . . |  |||   | |   .|||   .    |   .|.|   |   ||| . |..|| 
crkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfy..ewadasklpeymldmrasiklqyirsskktgvcigpimlvcatgve

RTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHY
.   .  || .. .| ||  . .   .| |. ||   ..    ||    
kcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystace
0049260 (Phosphotyrosine protein) phosphatases II 6-147 2.7e-27 90.7 In-house 24-144 (152) alignment 
Range on Protein: 6-147
Range on HMM: 24-144/152.0
KYWPEENEQYGKIIVTLEEKEELAD------FeirkfslrklsnqmetrmvkHFYFTSWPDHDVPEYATGLLEFWKRVRNSwEGPQSGPITVHCSAGVGR
..|    |.  ..||.| | .||.       .                    ..... |||| ||. .  ||.. . ..      ..||. |||||||||
dfwrmlkelgittivmltellelgklkceqyi....................qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgR

TGTFIVIDAMMeqikeeNLLDVYSYVSRIRAQRNFMVQRPSQYSFIHY
|||..... |.      . .... .|...|..|. .|. |.|. |...
tgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 7-152 4.5e-24 79.9 In-house 114-258 (267) alignment 
Range on Protein: 7-152
Range on HMM: 114-258/267.0
YWPEE---NEQYGKIIVTLEEKEELADFEIRKFSLrKLSNQMeTRMVKHFYFTSWPD-HDVPEYATGLLEFwkRVRNSWEGpQSGPITVHCSAGVGRTGT
.|| .    ..|  . |    ..|  |..|  . | |. |.  .. |  .|.  |    .   |   |.      .|  |   . |. |.||.||||.||
fwPPkmgqakkyqdltvehslekeendyqiitlel.kfknes.ahnvtlyyykkwnintnnkpylkplfgi..laknqlen.gnrPlvvacsdGvGrsGt

FIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
|.|||...|..|.|. .|.. .. .|| ||  .|.   .| .||  | | 
flvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 7-146 1.3e-13 45.6 In-house 50-197 (199) alignment 
Range on Protein: 7-146
Range on HMM: 50-197/199.0
YWPEE---NEQYGKIIVTLEEKEELADFEIRKFSLRK-LSNQMETRMVKHFYFTSWPDHDVPEYA--TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRT
|||       .|| . || .     .|. |  . | .  .    || . |. |||| ..  |. |   |..   . | . .|  .  |. |||| | | |
ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgft

GTFIVIDAMMEQIKEE--NLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
| |. .|  .   .|    ..|..    |.|  |  ..    .| ||.
gvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 7-146 1.3e-13 45.6 In-house 49-196 (198) alignment 
Range on Protein: 7-146
Range on HMM: 49-196/198.0
YWPEE---NEQYGKIIVTLEEKEELADFEIRKFSLRK-LSNQMETRMVKHFYFTSWPDHDVPEYA--TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRT
|||       .|| . || .     .|. |  . | .  .    || . |. |||| ..  |. |   |..   . | . .|  .  |. |||| | | |
ywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgft

GTFIVIDAMMEQIKEE--NLLDVYSYVSRIRAQRNFMVQRPSQYSFIH
| |. .|  .   .|    ..|..    |.|  |  ..    .| ||.
gvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 8-150 1.5e-11 38.2 In-house 138-282 (302) alignment 
Range on Protein: 8-150
Range on HMM: 138-282/302.0
WP---EENEQYGKIIVTLEEKEELADFEiRKFSLRKLSNQM-ETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVrNSWEGPQSGPITVHCSAGVGRTGTF
.|   .. ..|||. |     |.  . .  ....  | . . .. ...   .| |... ||.  . | .  . |    . . . .. .    |.|| |.|
fpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagaf

IVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
..  . .|......   .   |  ||.||  .|.  .|| ... |||
ltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
0048076 (Phosphotyrosine protein) phosphatases II 16-150 3.2e-28 93.6 In-house 14-140 (145) alignment 
Range on Protein: 16-150
Range on HMM: 14-140/145.0
GKIIvTLEEKEELADFEIRK-FSLrKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPqsGPITVHCSAGVGRTGTFIVIDAMMEqik
| .  | .. |.|.|. |.  ..|     . ..|.. ......||||.||. .  |||| . ...  . .  ||. ||||||||||||..... |..   
gslp.taldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll...

eENlLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALL
 .. ..... . ..|.|| ..|..|.|. |.....|
.lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 25-155 3.4e-19 64.0 In-house 146-273 (288) alignment 
Range on Protein: 25-155
Range on HMM: 146-273/288.0
KEELADFE-IRKFSLRKLSNQMETRM-VKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVY
|.. || . . | || . |...|... ||. ..  |.|. |||     | . .....        || ||.|||||||||.|.|  ..|... .. | . 
kkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlksl.....qkPivvhssaGvGrtgtlililialeslrlddflgir

SYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTF
| ... |..|   .|   || ..|  .|| . .
sllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 34-151 5.3e-23 76.2 In-house 172-285 (305) alignment 
Range on Protein: 34-151
Range on HMM: 172-285/305.0
RKFSLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRnswegPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLD-VYSYVSRIRAQR
..  |       ..| |.|...  |||  ||   . .||. .. |     |  |||.||||||.||||. .... ...|. . . ..     . .|| ||
tetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.....pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr

NFMVQRPSQYSFIHYALLE
|  .|   || |.|  .|.
nnsiqtdaqylfvhqviln
subfamily_PTEN_pd Subfamily PTEN 34-147 8.6e-12 40.4 In-house 65-174 (184) alignment 
Range on Protein: 34-147
Range on HMM: 65-174/184.0
RKF-SLRKLSNQMETRMVKHFYFTswpDHDVPEYATgLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIdAMMEQIKEENLLDVYSYVSRIRAQR
  . | || ...  . .|... |.   ||  |.    | |. . ...  |  ..  . ||| || ||||. ||   .... . |.  .. .. ...|.. 
ynlrserkydskkfdgrvavypfd...Dhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtkn

NFMVQRPSQYSFIHY
.  |. |||  ...|
kkgvtiPsqrRYveY
subfamily_DSP12_pd Subfamily DSP12 37-129 3.7e-06 21.4 In-house 38-123 (155) alignment 
Range on Protein: 37-129
Range on HMM: 38-123/155.0
SLRKLSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSwegpqSGPITVHCSAGVGRTGTFIViDAMMEQiKEENLLDVYSYVSRIR
.| . .... .   |. . .  |. |. ..    ..| .  ..       | . ||| ||| |  |...   .| . .. .| . .. |....
elpehklkkgkvstkfiqilDepeediLshldeavdFieealee.....egavlvHCqagvSRSvtivi.AYlmkk.eklslekAlklvkekk
0049772 (Phosphotyrosine protein) phosphatases II 38-161 3.4e-22 75.0 In-house 176-288 (314) alignment 
Range on Protein: 38-161
Range on HMM: 176-288/314.0
LrklsnqmeTRMVKHFYFTSWPDHDVPeYATGLLEFWKRVRNSwegPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEeNLLDVYSYVSRIRAqRN---F
.        .|.. ... . .||...|     ..|| . ...    .. ||. |||.||.||||||.|.. .| . .  .| .....| ..|   |    
f........erlgikylripvpDgsap.lledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpg

MVQRPSQYSFIHYALLEAVTFGDTEIE
... . || ||..||||.. |  ...|
fieqleqyefilealleylkflkkfye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 41-189 4.2e-31 102.7 In-house 82-230 (440) alignment 
Range on Protein: 41-189
Range on HMM: 82-230/440.0
LSNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPS
  | .|.| .|.... .|||. ||..|  .|.. . | .| |   .||. ||||||.||||  |..|... . |  . .|..|... .| .|  ||| | 
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYSFIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
||.|.| |.||..  ||| |  ...  |. |.      |  . |..||.
qyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
0048179 (Phosphotyrosine protein) phosphatases II 42-147 2.8e-27 90.6 In-house 41-139 (144) alignment 
Range on Protein: 42-147
Range on HMM: 41-139/144.0
SNQMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEgpQSGPITVHCSAGVGRTGTFIVIDAMMeqikEENlLDVYSYVSRIRAQRNFMVQRPSQ
 .. ..|.. ......||||.||.... |||| . ...  |  ..||. ||||||||||||..... |.    ... |.... . ..|..| ..|. |.|
epefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgq

YSFIHY
. |...
lrfLle
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 42-146 3.1e-15 50.4 In-house 181-281 (302) alignment 
Range on Protein: 42-146
Range on HMM: 181-281/302.0
SNQ-METRMVKHFYFTSWPDHDVPEYATGLLEFWKRVrNSWEgpqsGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPS
  .    . |. ..|..||||  |. |   |.  |   .|.       . ||||||||||||.. |   ..  ....  |. | |  .|. |   ||  .
kkkkkvkktvdilafsawpdhGapkeaytaldilkfc.esyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeq

QYSFIH
|  .. 
qliyll
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 42-153 1.5e-07 25.4 In-house 165-279 (303) alignment 
Range on Protein: 42-153
Range on HMM: 165-279/303.0
SNQMETRMVKHFYFTSWPDHDVPEYA--TGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVID-AMMEQIKEENLLDVYSYVSRIRAQRNFMVQR
||     ...  .. .||  ..|  .    . . |.         .| |      .|.||.||| ... | .   .|.. ||.   .  .|  |   || 
sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqn

PSQYSFIHYALLEAV
 ||.|...  | | |
lsqfsvvytllaehv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 44-189 7.8e-33 108.4 In-house 128-272 (392) alignment 
Range on Protein: 44-189
Range on HMM: 128-272/392.0
QMETRMVKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWeGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYS
  ..| |  |.|| |||.|||.... ||.| | |.  . |  . |. .||||||||||  | ||... . |.  ..||. .|. || .| .|||   ||.
gddartvaqfhftewPdkdvpkhtssllkfikevkadf.Gqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqya

FIHYALLEAVTFGDTEIEVQNLRMRLMQLAEKVAGTGMTGLEREFQ
||. |.|| . . .| | |  .  .| .|   . | . .   .||.
fiygavledllwrntlipvvhftdhlqdlstssdGdvrskqlkefr
subfamily_PTPDC1_pd Subfamily PTPDC1 48-145 3e-08 28.3 In-house 81-168 (182) alignment 
Range on Protein: 48-145
Range on HMM: 81-168/182.0
RMVkHFYFTSWPDHDVPEYaTGLLEFWKRVRNSWegpQSGPITVHCSAGVGRTGTFIVIDAMMEQikEenlLDVYSYVSRIRAQRNFMVQRPSQYSFI
. .  .|  .|.|..|.   . .|.  | |  .    | | ..||| || ||||  |    .  .  .   |.    .. .|..|   .|  .|  ..
qgi.yvynfgwkDygvasl.eriLdivkvvafal...qegkvavhChaGlGrtGvliacylvyak..r...ltaekaiklvrskrpksiqtreqvelv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 49-153 2.6e-14 47.7 In-house 177-276 (312) alignment 
Range on Protein: 49-153
Range on HMM: 177-276/312.0
MVKHFYFTSWPDHDVPEYATGLLEFWKRVRNswegpQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYA
 ..|. ..||||| .|.     | .   |..     .  |.  |||||||||||...|..|.  ..     .|      .| .|   |.   || .   .
klnhyqwaswpdhgmpdscdtalrllsavkk.....dkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrc

LLEAV
.|| .
vlefl
PTPc_DSPc_SM00012 50-151 5.3e-35 115.2 In-house 2-105 (105) alignment 
Range on Protein: 50-151
Range on HMM: 2-105/105.0
VKHFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQ-SGPITVHCSAGVGRTGTFIVIDAMMEQIKEE-NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHY
|||...|.|||| |||... .||. . |... .  . |.|. |||||||||||||...| ...|...| . .|.. .|...| ||. |||.  ||.|.. 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 50-150 6.6e-14 46.4 In-house 217-341 (350) alignment 
Range on Protein: 50-150
Range on HMM: 217-341/350.0
VKHFYFTSWPDH---DVPEYATGLLEF------WKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMME------QIKE-EN-------LLDV-YSYV
| ....  |.|      ||     ||           ..  .  .| || ||||||||||||.. .| ...      ....  .       . |.    |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

SRIRAQRNFMVQRPSQYSFIHYALL
 ..| ||  |||   |. ||. |||
nelrkqrismvqnldqfifiYeall
0038934 (Phosphotyrosine protein) phosphatases II 52-142 1.5e-10 36.5 In-house 81-166 (194) alignment 
Range on Protein: 52-142
Range on HMM: 81-166/194.0
HFYFTSWPDHDVPEYATGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIdAMMEQIKEeNLLDVYSYVSRIRaqrNFMVQRPSQY
...   .||. ..     ||.| . |    .  ..| . ||| ||.|||||...  ....  .  .. . . .....|   . ........
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm.saeeAialfrekR...pgaipnqdyl
PTEN_1 56-147 5.2e-08 27.9 In-house 100-187 (196) alignment 
Range on Protein: 56-147
Range on HMM: 100-187/196.0
TSWPDHDVPEYAtGLLEFWKRVRNSWE-GPQSGPITVHCSAGVGRTGTFIViDAMMEQIKeENLLDVYSYVSRIRAQRNFMvqRPSQYSFIHY
 ...|| .|  .  |... |.. ...   |. . . ||| ||.||.|| .    .|.  |  .  .  ..| . | ....    |||  ...|
fpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva.ayLmykgk.ltadeAlelvrekRppgapn..spsqerlley
subfamily_DSP19_pd Subfamily DSP19 58-129 3.3e-06 21.5 In-house 61-130 (152) alignment 
Range on Protein: 58-129
Range on HMM: 61-130/152.0
WP-----DHDVPEYATGLLEFWKRVRNSWegpqsGPITVHCSAGVGRTGTfIVIDAMMEqIKEENLLDVYSYVSRIR
 .     ..|. .|    |.| . .|..      | . |||.||| |. . .||  .|.  .| .| . ...|  .|
ieilDlpetdllsylkealdFieearskd.....gavlvHCnAGvSRsas.vviaylmk.keelsleealelvrear
subfamily_VSP_pd Subfamily VSP 59-148 1e-08 29.4 In-house 102-194 (212) alignment 
Range on Protein: 59-148
Range on HMM: 102-194/212.0
PDHDVPEYAtGLLEFWKRVRNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKE--ENLLDVYSY--VSRIRAQRNFMVQRPSQYSFIHYA
 ||.||.    || | |.|..  |  ..  ...||  | ||||| .    .. .| |  .. || ..     . ....   || |||. ...| 
ddhnvpkle.ellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 78-151 2.6e-10 34.2 In-house 257-342 (349) alignment 
Range on Protein: 78-151
Range on HMM: 257-342/349.0
RNSWEGPQSGPITVHCSAGVGRTGTFIVIDAMME----QIKEENLLDVYS--------YVSRIRAQRNFMVQRPSQYSFIHYALLE
|. ..  |. .. |||||| ||||... .| ...      .| | ... .         |  .| ||  |||  .|. .|. |||.
rlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 83-152 1.9e-14 48.3 In-house 225-294 (297) alignment 
Range on Protein: 83-152
Range on HMM: 225-294/297.0
GPQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEA
 |.. .. |||||||||.|  .  |....... . . || . .| .| ||  .||   |. ... | |. 
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_eak_pd Subfamily eak 83-174 1.2e-09 32.0 In-house 234-324 (332) alignment 
Range on Protein: 83-174
Range on HMM: 234-324/332.0
GPQSGPItVHCSAGVGRTGTFIVIDAMMEQI--KEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFGDTeiEVQNLRMRLMQLAE
 |   || . .. |  |.|.|.||| ... |  | .||  |  .. ... .|.  |    |.|||. ..|. .   .   ....|.  |.  ||
ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn..rlrdlkkyleayae
PTPc_motif_SM00404 83-130 7.8e-08 27.3 In-house 77-122 (140) alignment 
Range on Protein: 83-130
Range on HMM: 77-122/140.0
GPQSGPITVHCSAGVGRTGTFIVIDAMMEQikEENLLDVYSYVSRIRA
  . | . ||| ||| |..|.|.   |...  . .| ..|..|.. | 
ekkggkvlVHCqaGvSRSatliiaYlmryr..qlslaeayefvkerRp
subfamily_CG42327_pd Subfamily CG42327 84-149 1.3e-15 51.9 In-house 245-311 (319) alignment 
Range on Protein: 84-149
Range on HMM: 245-311/319.0
PQSGPITVHCSAGVGRTGTFIVIDAMMEQIKEE-NLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYAL
 . ||..|||| ||||||. |  |  .....|  . .|.   || .| .|   |.   || ||.  |
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
DSPc Dual specificity phosphatase, catalytic domain 85-131 4.4e-07 24.8 Pfam-A 72-116 (133) alignment 
Range on Protein: 85-131
Range on HMM: 72-116/133.0
QSGPITVHCSAGVGRTGTFIVIDAMMEqiKEENLLDVYSYVSRIRAQ
. . . ||| ||. |..|.|.   |..  |. .| . |..|.. | .
kgkkvlVHCqaGisRSatliiaYlmkt..knlslneAyefvkerrsk
DSPc Dual specificity phosphatase, catalytic domain 85-131 4.4e-07 24.8 In-house 72-116 (133) alignment 
Range on Protein: 85-131
Range on HMM: 72-116/133.0
QSGPITVHCSAGVGRTGTFIVIDAMMEqiKEENLLDVYSYVSRIRAQ
. . . ||| ||. |..|.|.   |..  |. .| . |..|.. | .
kgkkvlVHCqaGisRSatliiaYlmkt..knlslneAyefvkerrsk
subfamily_CDC14_pd Subfamily CDC14 86-111 4.1e-06 20.9 In-house 263-287 (328) alignment 
Range on Protein: 86-111
Range on HMM: 263-287/328.0
SGPITVHCSAGVGRTGTFIVIDaMME
.| |.||| ||.|||||.|    .|.
eGaiavhCkaGLGrtGtLiacy.lmk
subfamily_DSP10_pd Subfamily DSP10 88-130 1.6e-06 22.1 In-house 94-134 (159) alignment 
Range on Protein: 88-130
Range on HMM: 94-134/159.0
PITVHCSAGVGRTGTFiVIDAMMEQiKEENLLDVYSYVSRIRA
 . ||| ||. |  |. ||  .|.. .. .| | | .|.  |.
rvLvhCqaGisrsatv.viaYlmkh.lnlslndaykfvkekrp
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 90-156 2e-19 63.7 In-house 2-68 (69) alignment 
Range on Protein: 90-156
Range on HMM: 2-68/69.0
TVHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG
 ||||.| ||||||| |   | .|| | |.|..  |  .|  |  ||    .| ||| || ||. .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 91-156 2.7e-19 63.3 In-house 2-67 (69) alignment 
Range on Protein: 91-156
Range on HMM: 2-67/69.0
VHCSAGVGRTGTFIVIDAMMEQIKEENLLDVYSYVSRIRAQRNFMVQRPSQYSFIHYALLEAVTFG
||||.| ||||||| |   | .|| | |.|..  |  .|  |  ||    .| ||| || ||. .|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG