Gene NvecPTP-sf2-13 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily NvecPTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP069_AA protein Get Run
NvecP069_AA_0-244 phosphatase_domain Get Run
NvecP069_AA_256-535 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1-282 1.1e-130 431.9 In-house 43-320 (564) alignment 
Range on Protein: 1-282
Range on HMM: 43-320/564.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
|.||.|| |||| ||| |||.||||.   |.    ||||||||..|.. ..|.|||.|||......|||.|||....|.||||| | | .|.|||||||.
ankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPe

TNqPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAML
.. .. ||..||.| ..| .|||..||| .. . |.|.| . |.||| |||.|||..||..|....|. . ..... |..|||||||||||.||||||||
kg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividaml

RQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVMTKLEKIRPREQVSGYESEFQRLS
...||.|.||||.||.| | .|. ||||..||.|||.|.|||| ||.|.... ||.. ..||..... ....|.| |||||.
erikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLa
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1-242 3.6e-111 365.0 In-house 2-239 (239) alignment 
Range on Protein: 1-242
Range on HMM: 2-239/239.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
|||  || |||| |||||||.||||.    . | .|||||||.|. .||.|| |||.|| ||.|. |||.|.||||  ||||||||||| |.|||.||||
akkrvnkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

TNQpkPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAML
.     | .  |.| | | |||| .|||...     |.|..||||||||||||||||||||| .|.|| ..|   . ||..||||||||||||.||||||
sts..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

RQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEA
||||..| |||.|||.| | ||| |||| .|||||| |||||
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1-241 1.5e-110 363.0 In-house 3-239 (239) alignment 
Range on Protein: 1-241
Range on HMM: 3-239/239.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
|||  || |||| |||||||.||||.    . | .|||||||.|. .||.|| |||.|| ||.|. |||.|.||||  ||||||||||| |.|||.||||
akkrvnkaknryanivtydhsrvvlekl..sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

TNQpkPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAML
.     | .  |.| | | |||| .|||...     |.|..||||||||||||||||||||| .|.|| ..|   . ||..||||||||||||.||||||
sts..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

RQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
||||..| |||.|||.| | ||| |||| .|||||| ||||
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-251 2e-98 324.3 In-house 51-298 (298) alignment 
Range on Protein: 1-251
Range on HMM: 51-298/298.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASFLQGFDGTPkKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
|.||||| |||| .|...|..||||.      |  |||||||||....|..  .||.|.|....  |||.||..|  ..||||| | |  | |.||||||
arkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPd

TNqPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT-APWIVHCSAGVGRTGAFIVIDAM
..  . ||. |||| ..| |||..||.. |... ....| . | |||.|||||||..||.|| ...|.    ...  .| ||.|||||||.|.||.||..
eg.ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsv

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQ
| ..|...|||....|.. | .||..|||..|||||. |||||| .....|.
lervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndeie
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-247 2.1e-97 320.2 In-house 4-245 (250) alignment 
Range on Protein: 1-247
Range on HMM: 4-245/250.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASFLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEkCHKYWPd
||||.|| |||| .|...|..||||.      |  |||||||||.|.|.. | .||.|||....  |||.||..|  ..||||| | |  |. .|.||| 
akkpqnkeknryadiialdssrvvLekek..gdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.

TNQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH-NTAPWIVHCSAGVGRTGAFIVIDAM
..... ||. |||| ..| |||||.|.. ...|  ...| . |.||.||||||||..||||| ..||.  . .. ..|| ||.|||||||.||||.|||.
vekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCgS
| ..|..||||....... | |||..|....||||.....|.||.. .
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds.v
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1-279 3.2e-93 307.3 In-house 43-319 (319) alignment 
Range on Protein: 1-279
Range on HMM: 43-319/319.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASFLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
|.|.||| |||| ||..||.|||||.   |  .  ||||||||..|..   .|.||.|.|.|   .|||.|||.|..|..||||.| |  | |..||||.
askeenkkknryqnilaydrtrvvlseldgveg..sdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpe

TNqPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSN-EQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR-HNTAPWIVHCSAGVGRTGAFIVIDA
.| .. ||...| | ..|  .|| .| . .  . |. | | . ....| |||..||..||..| . |.| .  . ..  | .|||||||||||.|||.||
en.feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivlda

MLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVMTKLEKIRPREQVSGYESEFQ
|| . ||  |.|....|. .|  |. |||...|| ||. |.|||. .|.|.|.  .||. . .|..  .    .| | |||
mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetglerefq
0036941 (Phosphotyrosine protein) phosphatases II 1-255 2.1e-89 295.0 In-house 34-289 (297) alignment 
Range on Protein: 1-255
Range on HMM: 34-289/297.0
AKKPENKIKNRYGNIVTYDHTRVVLkgpggnRDGRSDYINASFLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
|..|||. |||| .|. ||||||.|       |. |||||||...|. . ..|.||.||| . ...|||.|||.....|||||| |.|  .|||..|||.
allpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgy.dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpl

T-NQPKPYGQYTVSLCKNEA--FADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHCSAGVGRTGAFIV
. .... ||..|| | . |   ..|||.||. ||   ..|.|.....|.| ||| |||.... .|.| ... .  ..  .  | .|||||||||.|.||.
eegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfia

IDAMLRQAK---EKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNL
.| ||.| .   . . |||...|.  |  ||..||| .||.|...|.|| | .. |.... .|
adlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
subfamily_PTPRB_pd Subfamily PTPRB 1-244 1.2e-88 292.0 In-house 46-286 (293) alignment 
Range on Protein: 1-244
Range on HMM: 46-286/293.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
|....|. |||| ||..|||.|| |.    . .  ||||||....|.  .|...||.|||.  . ||||.|||....|.||||| |.|. |.||..|||.
aelavnraknrytnilpydhsrvkLaal..kdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa

TNQPKPYGQYTVSLCKNEAFADYTVRTFLVTSapSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINES--RHNTAPWIVHCSAGVGRTGAFIVIDA
...|  ||. .|.| ..|   |...|.....   ..|.| . ||||| ||| |||. ....|.| ... ..    ....| .|||||||||||.|| .| 
deepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdr

MLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALV
.|.. .|. .|||.  | . | .| ..|||..||.|||..||. | 
llqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPRG_pd Subfamily PTPRG 1-258 1.6e-87 289.0 In-house 42-302 (563) alignment 
Range on Protein: 1-258
Range on HMM: 42-302/563.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
..||||| |||| |||.||..|| |..  |. ... |||||....|.    |..||.|||..  .||||.|.|... ..|||.| | |  ..||. ||| 
sqkpenkrKnRylnivaydrsRvklsplpgk.kkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk

tNQPKPYGQYTVSLCKNEAFADYTVRTFLVTS------APSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFI
 .... ||. .| | ..| .| |||||. .           .... ..|||.| |||.|||.... || | ||     .... | .||||||||||| .|
.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyi

VIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNV
|.|..|.| .....|.... ..  |  |...|||..||.|.| |.|||.  . |...| .....
vldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveel
subfamily_PTPRK_pd Subfamily PTPRK 1-279 5.2e-86 283.3 In-house 38-313 (314) alignment 
Range on Protein: 1-279
Range on HMM: 38-313/314.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
||| ||. |||.|.|..||..||.|.   |  |  ||||||... ..   |...|..|||..    |||..|..|.|. ||||| |.| .. || ||||.
akkdenreknrsgdilaydrsrvflitidg..dpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

TNQPkpYGQYTVSLCKNEAFADYTVRTFLVTS--APSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDA
  .   ||.  | | . |. |.. ||.| |.    . .|.| . |..|. ||| .||..||..|.. ... . . ..  . .|||||| ||||.||.|| 
dtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi

MLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVMTKLEKIRPREQVSGYESEFQ
.|  .....|||..| |.. |  ..|||.|..||.||. ..||| .|| | | . .....  .  .. |. . |  . |||
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefq
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-241 5.5e-85 279.9 In-house 42-277 (288) alignment 
Range on Protein: 1-241
Range on HMM: 42-277/288.0
AKKPENKIKNRYGNIVTYDHTRVVLKGpgGNRDGRSDYINASFLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
.....|. |||| ||..||..|| ||.  ..    .||||||...| ..  |||||.|||.  . .|||..|.... | |||||.|.|| |.||..||||
grlavnakknRyrnilpyDekrvklkk..leeeagaDYinasyidg.ekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd

TNQPKPYGQYTVSLCKNEAFADYTVRTFLVTsaPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAML
...|| ||. || | ...   |...|..|.    ..... | ||....|||.|||. .. .| ..... . .  .| | |||||||||||| ||..||..
adkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdali

RQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
 . .|....|. . |   |  |...|||. ||.||....|.
daveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPRA_pd Subfamily PTPRA 1-278 5.1e-84 277.0 In-house 53-330 (330) alignment 
Range on Protein: 1-278
Range on HMM: 53-330/330.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASFLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
|.| ||| |||. ||. ||..||.|    |. .  ||||||||..|.    .|.|||||| | . .|||.|.|. . . ||||| | |  .|||..||||
askeenkeknrvvnilPydfsrvilsvkeGvee..sdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

TNQpKPYGQYTVSLCKNEAFADYTVRTFLVTSAPS----NEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVI
      ||. .|.. ...   ||||| |||.  |     ...| . |.||| ||| |||  .  .|.. ||. .  . .. | .|||||||||||.|||.
eGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivl

DAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVMTKLEKIRPREQVSGYESEF
||.| . | ...||... |.  |  ||.||||. ||.||....||  . | |....  | . . || .  .. .  | | ||
davlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkigleeef
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1-251 1.8e-83 275.1 In-house 44-287 (315) alignment 
Range on Protein: 1-251
Range on HMM: 44-287/315.0
AKKPENKIKNRYGNIVTYDHTRVVLkgPGGNRDGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
||| ||| |||| ||..||..|| |  |  . |  |||.||.|..|..  ...|||||||   | .|||..|..| .. |||||.|.|| |.|. |||||
akkienkqknryiniiaydksrvql..pllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpd

TnqPKPYGQYTVSLCKNEAFADYTVRTFLVTSApsNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAML
      ||..||.. ..| . .|||||. |..   .. | ..|.|.| ||| |||.|..... . ...      . .. .|||||||||||.|| .||.|
k..kviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl

RQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQ
 ||. ....|.||...  |  | .|||. .|| ||. |.||..||| | | 
dqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsia
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1-255 7.2e-76 250.0 In-house 39-289 (315) alignment 
Range on Protein: 1-255
Range on HMM: 39-289/315.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASFLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
|....|  ||||.||. .|..||.|.    . .  |||||||.....|   | |||.||| . | ||||.||.||. . |||.| . || | || .||||
aretinfkknryknilPldsarvklevi..ddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd

-TNQPKPYGQYTVSLCKNEAFADYTVRTFlVTsAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAM
   .   .|.. |.| . || .| ..| . ||   |.|.| . |..|| ||||||.. ....|.. |..  . .... . .||||||||||| .| || .
rkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidev

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNL
. |.|....||..|.|.  | .|| .|||...| ||. |||| |    | |   ..
vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihf
subfamily_PTPN3_pd Subfamily PTPN3 1-242 3.6e-73 240.9 In-house 36-274 (280) alignment 
Range on Protein: 1-242
Range on HMM: 36-274/280.0
AKKPENKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASFLQ-GFDG--TPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKY
|.||||  |||| .|..||.||| ||      ....|||||....   ..  . ..|||.|||.. .. |||||||....|.||||| |.|  . |||.|
arkpenlsknryrdilpydatrvklk......esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPDTNQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVID
||.|..   ||...| . |...   | .| .... . ..|.| | |  .. |||.|||. .. .|.| ... .  . .. | .||||||.|||| .|...
WPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille

AMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEA
  |    ... | . . ||  |  | ..|||..|| |.  |.|..
talalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-279 2.1e-71 235.7 In-house 43-324 (325) alignment 
Range on Protein: 1-279
Range on HMM: 43-324/325.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASFLQGFDGTpKKYIAAQGPVEPSCDDFWQMV--WQerCSVIVMLTgLIEGSKEKCHKYW
| ||||| |||. |.|..|..||||.  .   |. |||||||.|. . .  . ..||| |   . .|.|..|  |.  |||.|.|   ... |..| .||
amkpenkaknrfknvvaldksrvvletkk..ddpssdyinasylrddkkk.dvflaaqaPltatindlWrlvldWr..csvvvvln.eldlgkdrcavyw

PDT-NQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKII--NE----SRHNTAPWIVHCSAGVGRTG
|.   . | .|   |.|   | ..||  | . |  .   | | . |...  |.| ||... .... . . .   .|      . ..| .|||||||||||
pkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

AFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVMTKLEKIRPREQVSGYESEFQ
.|| . ..| .  |.  |||...|.  | |||.||.| |||..|. |. ||...| ||.   ..   .. |..  |  |    | ||.
vfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekefe
subfamily_PTPRN_pd Subfamily PTPRN 1-241 4.1e-63 207.8 In-house 51-290 (297) alignment 
Range on Protein: 1-241
Range on HMM: 51-290/297.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
||...|  |||. ....|||.|| ||    . . .|||||||..   |     |||.|||.  .  |||||||.. . |||.|| | | . ..|..||||
akaeknvkknrskavlpydhsrvklkee..asaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

TNQpKPYGQYTVSLCKNEAFA-DYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAM
. . . |. | | |  .  .. || ||.| .    ..| | . |.||  ||..|||  | ..| ||.|.    |  ..| .||||.|.||||..|.|| .
eGs.evyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlv

LR-QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
|   .|  | .||   .   | .||..|.||||. |.  || |
lnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1-256 2.9e-61 202.0 In-house 40-249 (392) alignment 
Range on Protein: 1-256
Range on HMM: 40-249/392.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASFLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSkekchkywpd
|.|. |. ||||.||. || .||.|.    .    |||.|||....||   | |||.|||   | ||||.||.||. . |.|.| | ||           
aqkeinlkknryknilpydsarvklevi..ddipdsdylnasyipsfdn.ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

tnqpkpygqytvslckneafadytvrtflvtsaPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAML
                                   ...| . |.||| ||||.||......|.| |..  .  . | | |.||||||||||  | ||...
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvv

RQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLR
 .||. ..||..|.|   |  || |||||.|| ||. |||| |.   | |    . 
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhft
subfamily_PTPN1_pd Subfamily PTPN1 1-245 3.6e-61 201.4 In-house 27-273 (290) alignment 
Range on Protein: 1-245
Range on HMM: 27-273/290.0
AKKPENKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASFLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
||.|||. .||| ..  |||.|..|.      ..  ||||||... ..   ..|| .|||.   .| ||||||....  .|||  ..| .. ||..||| 
aklpenrnlnryrdvspydhsrikle......radndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

TNQP----KPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINES--RHNTAPWIVHCSAGVGRTGAFI
 ..         ...| | ..|    ||||.. ..   ..| | |...|.| ||| |||.  .| |.|  |. .     ..  | ..|||||.||.|.|.
geeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc

VIDAMLRQAKEKKV---VDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVC
..|..| . ..|.    ||| . . . |  |  ..||.||  | . |.||   .
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_PTPN14_pd Subfamily PTPN14 1-242 3.7e-58 191.9 In-house 44-295 (300) alignment 
Range on Protein: 1-242
Range on HMM: 44-295/300.0
AKKPENKIKNRYGNIVTYDHTRVVLKGpggNRDGRSDYINASFLQGF-DGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWP
|| |||. |||. ... |...|| |.    ... ...||||| ..    |. ..||.||||.|  . |||||||..  ..|||||  .|. |||..||.|
aklpenaeknrfkdvlPyednrvelsp...tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

DT---NQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKII------N---ESRHNTAPWIVHCSAGV
..   ..   .|.. |.   .|    .. ... .   ||.|.| ..   .| |||.|||.  .  | . ...       |   ||...  | .|||||||
kleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGv

GRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEA
||||  |. | ..   .  ...|| . ..  |  |  .|||  || |....... 
GrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1-168 4.3e-32 106.2 In-house 28-193 (297) alignment 
Range on Protein: 1-168
Range on HMM: 28-193/297.0
AKKPENKIKNRYGNIVTYDHTRVVLKGPGGNrdgrSDYINASFLQGFD-GTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWP
||..    |||| .|...| ||| |..   .    .||||| ..   |  .. ||| ||||.. . ||||..|...   ||||.. | |. ..||  |||
akrnsslrknryrdilatddtrvkllrvite....rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

DTNQPKPY-GQYTVSLCKNEAfADY-TVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKI
...| .   |.. |    . .  .. .|    ..    .|.| .    |  |||.|||     . ||. ..
svvqerlkagdvvveflssts.defdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
0050432 (Phosphotyrosine protein) phosphatases II 2-247 2.7e-94 311.3 In-house 64-303 (308) alignment 
Range on Protein: 2-247
Range on HMM: 64-303/308.0
KKPENKIKNRYGNIVTYDHTRVVLkgpggnrDGRSDYINASFLQGFD-GTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
..|||| |||| .|. |||.||.|       |. |||||||. .|.. . |.|.||.||| . ...|||.|||.....|||||| |.| ..|||..|||.
llpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwpl

T--NQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESrhNTAPWIVHCSAGVGRTGAFIVIDA
.  .... ||..|| | . | ..||||||. .|   ..| |.....|.| ||| |||......|.| ... .    .  | .|||||||||||.||..| 
elgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdl

MLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGS
.|.| .... ||....|.  |  ||.||||..||.|..||.|| | .  
lleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 2-243 1.2e-92 305.7 In-house 45-286 (288) alignment 
Range on Protein: 2-243
Range on HMM: 45-286/288.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASFLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDt
..|||. |||| .|. |||.||.|. ..|  .. |||||||...|.. . | .||.||| . ...|||.|||.....||||||.|.| ..|||..|||. 
llpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.

NQPKPYGQYTVSLCKNEAFADYTVRTFLVTSA----PSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVID
.... ||..|| | . | ..||||||. ||      ...| |.....|.| ||| |||......|.| .....  ...  | .|||||||||||.||..|
ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfiald

AMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEAL
 .|.| .....||....|.  |  ||.|||| .||.|...|.||.|
llleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 2-248 2.6e-92 304.5 In-house 24-279 (284) alignment 
Range on Protein: 2-248
Range on HMM: 24-279/284.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASFLQGFD----GTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKY
..|||. |||| .|. |||.||.|| ..|. .. |||||||...|.|     ..||.||.|||.. ...|||.|||.....||||||.|.| ..|||..|
llpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqY

WPDTNQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAP-SNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR--HNTAPWIVHCSAGVGRTGAFI
||...... ||..|| | . | . ||||||. .|    ..| |.....|.| ||| |||.... .|.| ... .  .  ..  | .|||||||||||.||
wplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfi

VIDAMLRQAKEKK---VVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGST
..| .|.| ....   .||....|.  |  ||.|||| .||.|...|.||.| .. |
aldllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0040438 (Phosphotyrosine protein) phosphatases II 2-281 2.7e-91 301.4 In-house 39-314 (317) alignment 
Range on Protein: 2-281
Range on HMM: 39-314/317.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASFLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDt
..|||| |||| .|. |||.||.|. .||  |  |||||||. .|.. ..| .||.||| . ...|||.|||.....|||||| | | ..|||..|||. 
elpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.

NQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLR
.... ||..|| |.. |  |..|.||. |.   ..|.|.....|.| ||| |||.. . .|.| ... .  ...  | .|||||||||||.||... ||.
getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmle

QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVMTKLEKIRPREQVSGYESEFQRL
| .... ||... |.  |  ||..||| .||.|...|.|| | .. |.. |..| . . ||  . . ..|...|.|...|
qlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkekelkll
0047943 (Phosphotyrosine protein) phosphatases II 2-243 5.5e-86 283.7 In-house 34-272 (273) alignment 
Range on Protein: 2-243
Range on HMM: 34-272/273.0
KKPENKIKNRYGNIVTYDHTRVVLkgpggnRDGRSDYINASFLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDT
..|||| |||| .|. |||.||.|       || |||||||...|.. ..| .||.||| . ...|||.|||.....|||||| |.| ..|||..|||..
llpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwple

NQ--PKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHCSAGVGRTGAFIVID
..  .. ||..|| | . | ..||||||. .|.  ..| |.....|.| ||| |||.. . .|.| ... .  ..  .  | .|||||||||||.||..|
ggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfiald

AMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEAL
 .|.| .... ||....|.  |  ||.|||| .||.|...|.|| |
llldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 2-243 9.8e-85 280.2 In-house 51-304 (307) alignment 
Range on Protein: 2-243
Range on HMM: 51-304/307.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASFL--------QGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEK
..|||| |||| .|. ||||||.|. ..|. .. |||||||.         .|.|  ..|.||.||| . ...|||.|.|.....||||||.|.|  .||
llpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrek

CHKYWPDTNQPKPYGQYTVSLCKNEAFADYTVRTFLVTSA-PSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN--ESRHNTAPWIVHCSAGVGRT
|..||||..... ||..|| | . |  ..|||||. ||   ...| |.....|.| ||| |||..   .|.| ... .  |.  .  | .||||||||||
caqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRt

GAFIVIDAMLRQAKEKKV---VDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEAL
|.||... |||| .. ..   ||... |.  |  ||..||. .||.|...|.|| |
GtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 2-242 1.1e-84 279.2 In-house 22-261 (263) alignment 
Range on Protein: 2-242
Range on HMM: 22-261/263.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASFLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDT
.|..|| |||| ||. |||||| || . ..    ||||||....|    .|||||.||| .  ..|||.|||.|....|||||   |  ||||..|||..
ekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

-NQPKPYGQYTVSLCKNEAFA-DYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAM
 .... .|...| | ..|    ....||. .|    .|.|...||... |||.|||. .. ||.. ... ........| .|||||||||||.|..|| .
sggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEA
|.. .|.| ||| . |.. |  ||.||||..|| ||..|.||.
lskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 2-242 1.1e-84 279.2 In-house 22-261 (263) alignment 
Range on Protein: 2-242
Range on HMM: 22-261/263.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASFLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDT
.|..|| |||| ||. |||||| || . ..    ||||||....|    .|||||.||| .  ..|||.|||.|....|||||   |  ||||..|||..
ekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

-NQPKPYGQYTVSLCKNEAFA-DYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAM
 .... .|...| | ..|    ....||. .|    .|.|...||... |||.|||. .. ||.. ... ........| .|||||||||||.|..|| .
sggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEA
|.. .|.| ||| . |.. |  ||.||||..|| ||..|.||.
lskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0039614 (Phosphotyrosine protein) phosphatases II 2-245 3.7e-83 274.7 In-house 52-291 (297) alignment 
Range on Protein: 2-245
Range on HMM: 52-291/297.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKeKCHKYWPDT
..|||| |||| .|. |||.||.||...|  |  |||||||...|.| ...|.||.||| . ...|||.|||.....|||||| |.| .. ||..|||..
llpenkdknrykdilpydhsrvklkpedgv.dldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpee

NQpkPYGQYTVSLCKNEAFADYTVRTFLVTSapSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHCSAGVGRTGAFIVIDAM
 .   ||..|| | | |  ..|||||. ||   ..| |.......| ||| |||.... .|.| ... .  ..  .  | .|||||||||||.||... |
gg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylm

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVC
|.| .... ||... |.  |  ||..||| .||.|...|.|| | .
leqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-243 1.3e-82 272.1 In-house 37-276 (281) alignment 
Range on Protein: 2-243
Range on HMM: 37-276/281.0
KKPENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASFLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDT
|..||. |||| ||| ||.|||...    ...  .|||||.|..|..| .|.|||.||||  |...||||||... |.|||.|  ||..| |||.|||| 
kadenvlknrYsnivaYDatrvkvtpn..eenkntDYinanfvpgykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

NQPKPYGQYTVSLCKNEAFADYTVRTFLVtSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT-APWIVHCSAGVGRTGAFIVIDAML
|.   ||..||.  ..|. | |  |.| . .. |.|.| . | ..| |||.|||. ....| |||.. . ....| || ..||||||||||..| .| ..
nselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlv

RQAKE-KKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEAL
..... .. .|. . |.  | .|  ||||  || |...|||.||
kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN6_pd Subfamily PTPN6 2-240 1.9e-82 271.7 In-house 50-294 (306) alignment 
Range on Protein: 2-240
Range on HMM: 50-294/306.0
KKPENKIKNRYGNIVTYDHTRVVLKgpgGNRDGRSDYINASFLQ-GFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
.||||| |||| ||. .|||||.||    .    ||||||....  . |. |.|||.|| .|    |||.||||| . ||||.|  .| .|||| .||||
akpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPd

TNQPKPYGQYTVSLCKNEAFADYTVRTFLVT-SAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT----APWIVHCSAGVGRTGAFIV
... . ||...|. ..... |||..|...|.    ..|.| ..||||..|||.|||.   ||| | ... ..... .     | .||||||.||||.|||
eeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiv

IDAMLRQAKEKKV---VDIYNYVRATRGDRPNMVQTKDQYVFIHRAVL
||..|.. ..|..   .||.. |. .|  |  .|||..|| |...|. 
iDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
0043336 (Phosphotyrosine protein) phosphatases II 2-241 3e-82 271.5 In-house 41-275 (278) alignment 
Range on Protein: 2-241
Range on HMM: 41-275/278.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASFLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPdt
..|||| |||| .|. |||.||.|.  ||  |  |||||||.. |.. ..| .||.||| . ...|||.|||......|||||.| | ...||..|||  
llpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..

NQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLR
.... ||..|| | | | ..||||||. ||   ..| |....||.. ||| |||   . .|.| |....  ...  | .|||||||||||.||... .|.
ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllle

QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
|..  . ||... |.  |  ||..||| .||.|...|.||
qlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 2-262 2.3e-80 265.0 In-house 44-305 (307) alignment 
Range on Protein: 2-262
Range on HMM: 44-305/307.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASFLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDT
.| ||..|||| .|...|.|||.||   |  .  ||||||||..|.. . ||.||||.|||   .|||.|...    .||||. | | ...||.||||. 
ekkenalknRyedikafDktRvkLkking..kedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie

nQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAP-----SNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVI
 . . ||.  | | ..|   ||. |.. |.         ...| . |||.| |.|  ||. |...|.. ... .  ..| .| .|||||||||.| |. .
.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifval

DAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVMTKL
| .| | |. . |||.. |.  | .|. .||  .||||..||.|.    | ||..  .| . . .|
dsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
0040439 (Phosphotyrosine protein) phosphatases II 2-243 5.8e-78 257.2 In-house 7-246 (249) alignment 
Range on Protein: 2-243
Range on HMM: 7-246/249.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGnrDGRSDYINASFLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDt
..|||| |||| .|. |||.||.|.  .|     |||||||.. |.. ... .||.||| . ...|||.|.|.....|||||| | |  .|||..|||. 
llpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

NQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHCSAGVGRTGAFIVIDAM
.... ||..|| | . | ..||||||. .|    .| | ......| ||| |||..   .|.| ... .  ..  .  | .|||||||||||.||... |
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEAL
|.| .... ||....|.  |  ||..||. .||.|...|.|| |
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 2-241 1.2e-77 255.9 In-house 5-241 (245) alignment 
Range on Protein: 2-241
Range on HMM: 5-241/245.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASFLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDt
..|||| |||| .|. ||||||.|. .||. |  |||||||.  |.. ||| .||.||| . ...|||.|.|......||||| . | ...||..|||. 
llpenkdknrysdilpydhtrvklspdggdld..sdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

NQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESR-HNTAPWIVHCSAGVGRTGAFIVIDAML
.... ||..|| | . | ..||||||. ||  ...|.|....||.. ||| ||| .   .|.| . . .  . ..  | .|||||||||||.||... ||
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

RQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
.|... . |.... |.  |  ||..||| .||.|...|.||
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN12_pd Subfamily PTPN12 2-242 2.6e-75 248.0 In-house 36-276 (290) alignment 
Range on Protein: 2-242
Range on HMM: 36-276/290.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASFLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDT
.|.||. |||| .|. ||..||.|.   ..    ||||||.|..| .| ...|||||||.    ||||.|.|. . ...||.  ..|  | ||..|||..
ekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpee

NQPKP-YGQYTVSLCKNEAFA-DYTVRTFLVTSApsNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAM
.. .  .|...|.| ...|.  |...||. |.    .|.| .||.|.| |||.|||. |. .|.. ... .  ... || .|||||||||||. |.|| .
geeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyv

LRQAKEKKV---VDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEA
 .. |..|.   .|... |.  | .|. .||||.||.....||.| 
rellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
0037934 (Phosphotyrosine protein) phosphatases II 2-241 1.3e-74 246.0 In-house 6-240 (243) alignment 
Range on Protein: 2-241
Range on HMM: 6-240/243.0
KKPENKIKNRYGNIVTYDHTRVVLkgpggnrDGrSDYINASFLQGFDgtpkKYIAAQGPVEPSCDD----FWQMVWQERCSVIVMLTGLIEGSKEKCHKY
..|||. |||| .|..|||.||.|       .| ||||||.. ....    ..|| ||| . ...|    ||.|.|.....|||||| |.| ..|||..|
llpenlsknrysdilpydhsrvkl.......eg.sdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPdtNQPkPYGQYTVSLCKNEAFADYTVRTFLVTSAP-SNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINE--------SRHNTAPWIVHCSAGVG
||  ..   ||..|| | . | ..||||||.|..  . ....|....||.. ||| |||.  . .|.| .....          ...  | .||||||||
wp..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGAFIVIDAMLRQAkekKvVDIYNYVRATRGDRPN-MVQTKDQYVFIHRAVLE
|||..|... ||..    . ||....|.  |  ||. .||| .||.|...|.||
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN9_pd Subfamily PTPN9 2-241 1.3e-67 223.0 In-house 38-288 (297) alignment 
Range on Protein: 2-241
Range on HMM: 38-288/297.0
KKPENKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWP-D
|.. |  |||| ... ||.|||||.    . |  ||||||.|..|.   .| .||.|||..  ..|||.|||.... |||| | ..|  . || .||| .
klranleknrytdvlcydetrvvlakv..dedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

TNQPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINE-------------SRHNTAPWIVHCSAGV
... . .|...||  . |   ||.||.. .. .  .|.| .  . |. ||| |||. |...| ...|. ..              . .  | .||||||.
eessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
||||.|| .|  | . .|. .||. . |.  |  |  ..|| .||.| . ||||
GrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPN13_pd Subfamily PTPN13 2-243 5.7e-66 217.6 In-house 33-269 (273) alignment 
Range on Protein: 2-243
Range on HMM: 33-269/273.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGnrdgrsdYINASFLQGFDG-TPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD
|| ||| |||| |.. ||.||| |.. ||       |||||...   |    .|||.|||.  ...|||||||. ...||.|.|   |. | |||.|||.
kkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPe

TNQP--KPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRhNTAPWIVHCSAGVGRTGAFIVIDA
...   | .....|.| | .   ...||.. |.   |.| | . . .|. ||| |||. |. .|.| ... .  . ...| .||||||.||.|..|.||.
sknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidv

MLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEAL
.|   . .| .|. . ||  |  |  .|||||||.|...|.||.|
vlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
0049772 (Phosphotyrosine protein) phosphatases II 2-243 4.7e-43 143.5 In-house 42-280 (314) alignment 
Range on Protein: 2-243
Range on HMM: 42-280/314.0
KKPENKIKNRYGNIVTYDhTRVVLkgPGGNRDGrSDYINASFLQGFdgtpKKYIAAQGPVEPSCDDF----------WQMV--WQERCSVIVM-------
....|. |||| .|. .| .||.|  || . .| |||||||.. ||    .|.||.||| |  ..||          |.||  .. .. .|||       
dlflnrdknryldilpad.nrvil..pglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LTGLIEGSKEKCHKYWPDTNqpkpygqytvslckneafadytvrtfLVTSAPSNEQRFIYQYHFTVWPDKGVPqYATAVLRFRKKI
              |..| ..  | . ..... .                           ..  |.  .| ...|. . .|| ..|     ...| . |
delsrLdaAlgKtpllildgngneptaadlellk..........................eelydpelferlgikylripvpDgsap.lledfdeflefi

INEsrHNTAPWIVHCSAGVGRTGAFIVIDAMLRQAKEkKVVDIYNYVRATRG--DRPNMVQTKDQYVFIHRAVLEAL
 .   ..  | .|||.||.|||| |.|.. .... .   . .....||..|    .|..... .||.||..|.||.|
eea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2-241 6.4e-42 138.3 In-house 44-285 (305) alignment 
Range on Protein: 2-241
Range on HMM: 44-285/305.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGnrdgrSDYINASFLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDT
|. ... |||| ..   |. || |.||        .|| | ..      ||..| .| |.| .| ||| | .|..   | ||  |.|   .||..|..  
keaqeagknrykdvgcldnnrvklegpwp.....heyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask

NQPK----PYGQYTVSLCK---NEAFADY----TVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRfrkkIINESRHNTAPWIVHCSAGVGRT
....      ||  .  ..   .  | .       .| ||   | ...| . .||.  |||.|||   .|.|     .....|    | .||||||.|||
dkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlaile....llekarpskgpivvhcsagigrt

GAFIVIDAMLRQAKEKKVVD-IYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
|. .... .| |  . ....     ..  | .| | .|| .||.|.|. .|.
gsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2-49 1.1e-09 32.2 In-house 43-88 (440) alignment 
Range on Protein: 2-49
Range on HMM: 43-88/440.0
KKPENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASFLQGFDG
  |.||.|||| ||..|||.||.|.   |  |  |||||||...| . 
slpnnkvknryrnilaydhsrvmleevkgvpd..sdyinasyingies
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 3-281 2.3e-97 320.9 In-house 43-318 (318) alignment 
Range on Protein: 3-281
Range on HMM: 43-318/318.0
KPENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDtN
.| || |||| ||..|||||| |.   |.    ||||||....|.    |.|||||.|.   ..|||.|||.  ..|||||| . | .|.|.|.|||. .
epvnkaknryanilaydhtrvkLqmlegee..gsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs.k

QPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINES-RHNTAPWIVHCSAGVGRTGAFIVIDAMLR
... ||. .| | ..  ..||..|.| ||   ..|.| . |||.| |||.|||. .. .| . ... .   .... | .||||||||||| ||..|..|.
gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdille

QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVMTKLEKIRPREQVSGYESEFQRL
..|. ..||....|.  |  |. ||||.|||.||. ..|||| .| |...| .||. . .|..  |    .  . |||||
rikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefqrl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 3-264 1.9e-88 291.6 In-house 43-304 (305) alignment 
Range on Protein: 3-264
Range on HMM: 43-304/305.0
KPENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASFLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTN
| .|| |||. .|...|. |. |.    .    |||||||...|...  ||||.||||..   .|||.....|. |.|||||.|.|| |.||..|||.. 
keankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesk

QP-KPYGQYTVSLCKNEAFADYTVRTFLVTS-APSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT-APWIVHCSAGVGRTGAFIVIDAM
.  | .|...| |  .....||. | . ..    ..|.| . ||..| |||.||||.||..|.. |.. .. ...   | .|||||||||||.||..| .
tekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdia

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVMTKLEK
| ..|. .|||....... |  |..||||.|||||.| |. | . || |.|   |||  . ||.|
lerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnklkk
0045098 (Phosphotyrosine protein) phosphatases II 3-245 2.6e-79 261.7 In-house 30-274 (278) alignment 
Range on Protein: 3-245
Range on HMM: 30-274/278.0
KPENKIKNRYGNIVTYDHTRVVlkgpggnrdgrsDYINASFLQGFdgtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDtN
...|. |||| .|. |||.||.            ||||||...|.   |||.||.||| .  ..|||.|.|.....||||||.|.|...|||..|||. .
ylgnldknRykdilpydhsrVk............dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.g

QPKPYGQYTVSLCKNEAFADYTVRTFLVTSA----PSNEQRFIYQYHFTVWPDKGVPQYA--TAVLRFRKKIINESRH-------------NTAPWIVHC
... ||..|| | . | . |||.||.|||      ...|.|.....|.. ||| ||| .   . .|.. . | .  ..             .  | .|||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

SAGVGRTGAFIVIDAMLRQAkeKKVVDIYNYVRATRGDRPN-MVQTKDQYVFIHRAVLEALVC
||||||||...... ||..   ...||....|.  |  ||. .||...||.|.....|| | .
saGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_CG7180_pd Subfamily CG7180 3-247 8.4e-57 187.1 In-house 39-294 (296) alignment 
Range on Protein: 3-247
Range on HMM: 39-294/296.0
KPENKIKNRYGNIVTYDHTRVVLKGPGGNRDgrSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKeKCHKYWPDTN
. ||. |||. ..| ||..||||.  .|. .  ||||||.. ..|   .|.||  ..|.. . |.||..|..| .| .|.||   . .| ....||| . 
rkenreknrdvkvvPyDynRvvLekldGeek..sdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

qPKPYGQYTVSLCKNEAFADYTVRTFLVTSA----------PSNEQRFIYQYHFTVWPD-KGVPQYATAVLRFRKKIIN---ES--RHNTAPWIVHCSAG
  . ||.  | . ... .|. . ||| .|             . |.| . ....|.|.  . ||  ..|.. .|...     .   . ...| .|..| |
.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

VGRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGS
..|.|... ||| | ...... ||....|.  | .||..|.....| .|   .|||..|. 
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_ptpA1_pd Subfamily ptpA1 3-202 5.1e-37 122.6 In-house 44-255 (418) alignment 
Range on Protein: 3-202
Range on HMM: 44-255/418.0
KPENKIKNRYGNIVTYDHTRVVLKGPGgNRDGrSDYINASFLQGfdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTN
|  |  |||| ||.  .|||| ||    ...| |||||| ...|    ||..|..|||.  .  |||.|||..|| .||||.   |  . || .|||.  
kkhntsknrytnilpvnhtrvqlkkiq.dkeg.sdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

QPKpygQYTVSLCKNEAFADYTVRTFLVTSAP-------------SNEQRFIYQYHFTVWPDKGVPQYATAVLRF------RKKIINESRHNTAPWIVHC
  .   |...    || |  |.|    |   |               | | | ||..  |||. .|...  . ..      |.. |  |     | ||||
gge...qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

SAGVGRTGAFIVIDAMLRQ
||||||||.|     |...
sagvgrtgtfctavimmkk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 3-242 1.9e-36 120.2 In-house 34-268 (281) alignment 
Range on Protein: 3-242
Range on HMM: 34-268/281.0
KPENKIKNRYGNIVTYDHTRVVLKGPGGNRDgRSDYINASFLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTN
.| |. |||| ||   | .|| ||    |..  .||| | ...      . || .||| . .  |||.|.|||  . ||||  ..|  .||| .|.|   
qpvnnkknrylnipcldisrvqlkvkmpnkn.stdyihanyirs.pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

QP-KPYGQYTVSlcKNEAFAD-YTVRTFLvTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHCSAGVGRTGAFIVIDAML
.    . ...||   ...  .   | | |   .   | |.| .. .  |||  ||. .  .|.  .||    |  ..| ..||||||||.|... ..  |
hcclqfdklsvs..yedstvnkslvttrl.nlsyegetrlithwlwkewpdwqvpessevmlkilrki....rarstppvihcsagvgrsgtlmaveial

RQAKEK-KVVDIYNYVRATR-GDRPNMVQTKDQYVFIHRAVLEA
.  . .  . || . |   |   |   ||| .||..| . .|. 
qsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 3-153 1.7e-14 48.0 In-house 93-234 (244) alignment 
Range on Protein: 3-153
Range on HMM: 93-234/244.0
KPENKIKNRYGNIVTYDHTRVVL-KGPGGNrdgrsDYINASFLqGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLtglieGSKEKCHKYWPDT
.|.|  ||| |  . .|  || | ||  ||      ||||||. |  |   .|| .| |.  .  |||.|. .    |.|.|     || |.  .||||.
npnnswknregaglpfdfnrvplskgsmgn.....tyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvl.....gsveeedeywpds

NQPKPYG-QYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKG
.  . |  . ||.|   . | .     . . |   .  . .  .  . ||  |
eplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 4-241 1.1e-138 455.1 In-house 1-237 (237) alignment 
Range on Protein: 4-241
Range on HMM: 1-237/237.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNrdgrSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQ
.||||||||||||.|||.||||||.|..    ||||||..|.|||||||||||||||.|.||||||||||||.||||||||||||| ..|||||||.|.|
senkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq

PKPYGQYTVSLCKNEAFADYTVRTFLVTSA-PSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRH--NTAPWIVHCSAGVGRTGAFIVIDAML
|..||..||||.|.|.|.|||||..|..     .| |.|.||.||.|||.||||...|.|||||.|||.|.|  ...|||.|||||||||| |.||||||
paaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

RQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
||||||||||||||| .   ||| ..||||||||||...||
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 4-259 5.6e-78 257.4 In-house 59-307 (319) alignment 
Range on Protein: 4-259
Range on HMM: 59-307/319.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTgliegsKEKCHKYWPDTNQ
..|| |||..||...|...| |.   |     ||||||||..|.   ..|||||||| . . .|||.|.|. .|| ||.||      |.|| .|||   .
dqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

PKpYGQYTVSLCKNEAFADYTVRTFLVTS-APSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKK--IINESRHNTAPWIVHCSAGVGRTGAFIVIDAML
 | .... |..   |  |.|.|| . ..  .  ...| | |.||  |||.|||.|.. ..|. ||   ...  .. |. .|||||||||||..||.|..|
ik.eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvll

RQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVM
 . ||.| ||.||.||  | .|...||   || ||. |.||  . | .|.  |..   .
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 4-259 6.5e-77 253.8 In-house 23-271 (284) alignment 
Range on Protein: 4-259
Range on HMM: 23-271/284.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRdgRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTgliegsKEKCHKYWPDTNQ
..|| |||.|.|...|...| |.   |.    ||||||||..|.   ..||||.||| . . .|||.|.|. .|| ||.||      |.|| .|||   .
dqnkdknrighilafdknvvklerliGee..fsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

PKpYGQYTVSLCKNEAFADYTVRTFLVTS-APSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKK--IINESRHNTAPWIVHCSAGVGRTGAFIVIDAML
 | .... |..   |  ..|.|| . ..  .  ...| | |.||  |||.|||.|.. ..|. ||   ...  .. |. .|||||||||||..||.|..|
ik.eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvll

RQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVM
 . ||.| ||.||.||  | .|...||   || ||. |.||  . | .|.  |..   .
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 4-244 6.1e-74 243.5 In-house 44-284 (290) alignment 
Range on Protein: 4-244
Range on HMM: 44-284/290.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDGRSDYINASFLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQ
..|| .||. ||| ||  |..|.  .|..|   .||||....|.    |.|||.||||.    |||...|||....|||||  ||  |.||..||||...
ssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdt

PKpYGQYTVSLCKNEAFADYTVRTFLVTSAPS-NEQRFIYQYHFTVWPDKG-VPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLR
 . ||.... | ..|.. .|. |.. |..  | .... . ||..| |...| |....| .| ... . .. ..   . .||||..|||.. |....  . 
ka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin

QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALV
..| . |.|... ..  |  .|..|||..|| .|.. ||..| 
kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 4-249 5.2e-72 237.2 In-house 45-284 (287) alignment 
Range on Protein: 4-249
Range on HMM: 45-284/287.0
PENKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASFLQGFDGTpKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQ
..|| |||. .|. .|  ||.||      . . |||||.|..|.    |..|.|..|.     .||....... ..||||. . |  .|.|..|||... 
sqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks

pKPYGQYTVSLCKNEAFADYTVRTFLVTSAP-SNEQRFIYQYHFTVWPDKG-VPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLR
   .|.|...| ..|  |.|..|.. |.    ..... . ||..| |...| |....| .| . ... .. ..  .. .||||..|||.. |. ..  ..
.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattin

QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTD
..|.  |.|... ..  |  .|..||| .|| ||  .||| | ...| 
kckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 4-249 3.6e-55 181.8 In-house 38-299 (301) alignment 
Range on Protein: 4-249
Range on HMM: 38-299/301.0
PENKIKNRYGNIVTYDHTRVVLKGPGGNRDGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTN-
 |||  ||. ||..||. |..||        . .|||||...|.    ||.||||||..    |||...|||. . |||.|.| ||.|.||..|||... 
eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea

QPKPYGQYTVSLCKNEAFADYTVRTFLVTSA-PSN--------------EQRFIYQYHFTVWPDKGV-PQYATAVLRFRKKIINESRHNTAPWIVHCSAG
. . .|. || | .. .. |...| . |.    ||              . . . |.. | ||. || ....| .    . |. . . . .| .||||..
eseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdt

VGRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTD
|.|.| .. ..  | |.|   |||... ..| |  .| .|.| .||..|. .. . | . || 
VsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnsty
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 5-253 1.4e-71 236.1 In-house 50-294 (297) alignment 
Range on Protein: 5-253
Range on HMM: 50-294/297.0
ENKIKNRYGNIVTYDHTRVVLKGpgGNRDGRSDYINASFLQGFDGtpkKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKeKCHKYWPDTNQp
 |  |.|| ||. ||  || |.    | |  |||.||||..|.     ..|. | | . . .|||.||..|. |.||||. . |. | || .||.|.   
vnfeksRYkniLPydssRvkLai..vnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv.

KPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQ--YATAVLRFRKKIINESRHNTA-PWIVHCSAGVGRTGAFIVIDAMLR
...|. .| |   .    .  |.. ||   .  .|.. ||.|. |||| |..   |...| . . . ..  .|.  | .|||.||||||| .. || .. 
ttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvva

QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAP
.||..| |||...|.  | .||..||||.|| |.. ||||||..  |.||| 
eakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 5-258 4.4e-64 211.1 In-house 32-281 (283) alignment 
Range on Protein: 5-258
Range on HMM: 32-281/283.0
ENKIKNRYGNIVTYDHTRVVLKGPGGnrdgrsDYINASFLQ--GFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTN
||| |||. .||..|  || ||          |||||.|.     .   ||||.||.|..    |||.||..|. . ||||| | |. ..|| .|||   
enkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

QpKPYGQYTVSLCKNEAFADYTVRTFLVTSAPS-NEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLR
  . ||..||.| |. .   .... .|.    | ... ..  | .  | . |      ....| | | .  ... .| .||||.|.|||..|| . | . 
s.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvk

QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNV
.|. . |||... |.  | .|. .|||.||| ..| .|||  .|| |.| | .| . 
daltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqst
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 5-241 2.2e-42 139.9 In-house 32-257 (267) alignment 
Range on Protein: 5-241
Range on HMM: 32-257/267.0
ENKIKNRYGNIVTYDHTRVVLkgpggnRDGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGskeKCHKYWPDT-NQ
.|. .||. . . ||.|||.|      |.   .|||||...|.  | ...|. |.|.. .  ||.... .....|||.||   ..   . ...||    |
knqernrlddnlpyddtrvil......rtkeeeyinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgq

PKPYGQYTVSLCKNEAFADYTVRTFLVTSApSNEQRFIYQYHFTVWPDKGV-PQYATAVLRFRKKiiNESRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQ
 | | . ||  . ..   || . |. .     .  . .  |..  |  .     |   ..    |  |.      | .|.||.||||.|.|.|||..|..
akkyqdltvehslekeendyqiitlelkfk.nesahnvtlyyykkwnintnnkpylkplfgilak..nqlengnrPlvvacsdGvGrsGtflvidsqler

AKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
||.  |.||....|  |  |. .|.||..|..||. . |
aktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_egg_pd Subfamily egg 5-240 3.1e-27 90.1 In-house 39-267 (307) alignment 
Range on Protein: 5-240
Range on HMM: 39-267/307.0
ENKIKNRYGNIVTYDHTRVVLKGPGGNRDGrsDYINASFLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGskEKCHKYWPDT-NQ
.|. | |   .   | .|| |. . |   .  |.| |  ..| .    ..| || |.  . ||||.||.||..  |||||   |   |.|. ||| . ..
nnlekarskrvhckdssrvklelrrGqyld..dfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesd

PKPY--GQYTVSLCKNEAFADYTVR-TFLVTSAPSNEQRFIYQYHFTVwpdkgvpQYATAVlRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDA--
.  .  | . .   | .  ||   | | |    . .|.||.  .   |       .... |  .  ...   |. . | .|..  || ...... |.   
slvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdv.......nnssdv.ysplrvlrklrnlskpvvvqdilGvskaatlvaieial

--MLRQAKEKKVvdIYNYVRATRGDRPNMVQTKDQYVFIHRAVL
  .||    | .  . . |   |  |.  |..  .|.|..| ||
lsllrGpitksl..vlravvflrlrrrlsvesvllylfvyrlvl
Y_phosphatase Protein-tyrosine phosphatase 6-241 5.3e-83 273.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 6-241
Range on HMM: 1-235/235.0
NKIKNRYGNIVTYDHTRVVLkgpgGNRDGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWP-DTNQP
|| |||| .|. ||.||| |     ...|.||||||....|.. ..||.||.|||.. ...|||.|||||...|||||| | | ..|||..||| .....
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

KPYGQYTVSLC-KNE-AFADYTVRTFLVTSAPSN-EQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLR
. ||...| |  |.. . ..||.|.. ...  .. |.| ..|.|.| |||.|||. ....|.. .|. ........| .||||||||||| |...|..|.
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
|..... ||....|.  |  ||.|||. .||.|...|.||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 6-241 5.3e-83 273.4 In-house 1-235 (235) alignment 
Range on Protein: 6-241
Range on HMM: 1-235/235.0
NKIKNRYGNIVTYDHTRVVLkgpgGNRDGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWP-DTNQP
|| |||| .|. ||.||| |     ...|.||||||....|.. ..||.||.|||.. ...|||.|||||...|||||| | | ..|||..||| .....
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

KPYGQYTVSLC-KNE-AFADYTVRTFLVTSAPSN-EQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLR
. ||...| |  |.. . ..||.|.. ...  .. |.| ..|.|.| |||.|||. ....|.. .|. ........| .||||||||||| |...|..|.
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
|..... ||....|.  |  ||.|||. .||.|...|.||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 6-279 4.3e-77 254.3 In-house 43-312 (515) alignment 
Range on Protein: 6-279
Range on HMM: 43-312/515.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINASFLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD-TNQP
|  ||||.||. || .|| |.    | .  |||.|||....||   | |||.||| . | ||||..|.||. . |.|.| | || | || |||||   . 
nfkknryknilPydsvrvklevi..ndnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

KPYGQYTVSLCKNEAFADYTVRTFLVTSApsNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQAK
  .|.. |.|   || .. . |.. |.    .. | . |.||| |||||||. ....|.. |..  .  . | | |.|||||||||| .| || .. .||
vkfGsikvelvsleactggikrkltvlkg..ddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahak

EKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNLRNVMTKLEKIRPREQVSGYESEFQ
. ..||..|.|.  | .|| .|||..|| ||. |||| |    | |    . . .  |      .  |    |||
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 6-241 2.4e-69 228.5 In-house 28-266 (274) alignment 
Range on Protein: 6-241
Range on HMM: 28-266/274.0
NKIKNRYGNIVTYDHTRVVLKGPGGNrDGRSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQP-
.. |||| .|.  ...||.|.   .. |  |.|||| ...|.|.. | |.|.|||.    .|||.|..||...|||||| | |  ..||..|.||...  
sqtknryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

--KPYGQYTVSLCKNEAFADYTVRTFLVTSAPSneQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN---ESRHNTAPWIVHCSAGVGRTGAFIVIDAM
  . ||.  .   |     ||.||.... .. .  .| .. | .| |||. .|. |...|.. ... .   |. ...|| .||||||.||||.|| |.  
iserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
.|| .|..|||. . |   | ||  ||||..|| .||||. .
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 6-241 4.6e-62 204.5 In-house 20-262 (270) alignment 
Range on Protein: 6-241
Range on HMM: 20-262/270.0
NKIKNRYGNIVTYDHTRVVLkgPGGNRDGRSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQP-
.|  ||| .|.   .|||.|  .  . | .. |||| ...|||| .||||||.||.. .  .||.|.|.|. . |||.||| |  ..|| .|||  ..  
gkklnRyadiLPsPatRvrl..eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

--KPYGQYTVSLCKNEAFADYTVRTFLVTsAPSNEQRFIyQYHFTVWPDKGVPQYAT------AVLRFRKKI---INESRHNTaPWIVHCSAGVGRTGAF
    .|. .|  ...|    | ..   ..   ..|.| .  .... |||.|||. .        .|.  ...    .| .... |..||||||||||| .
vkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtl

IVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
|..| ..|  .|.| ||. . ... | ||...||. .|| |...||.|
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN23_pd Subfamily PTPN23 6-242 1.2e-61 203.0 In-house 43-279 (288) alignment 
Range on Protein: 6-242
Range on HMM: 43-279/288.0
NKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD-TNQP
.  |||. .|. |||.||.|.      ... |||||||...   .  ..||.|.| ...  |||.||.... ||||||.   |  |.|...|||  ....
yseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

KPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIIN----ESRHNTAPWIVHCSAGVGRTGAFIVIDAML
. .|...|.| ...    .  |.. ..  .... . .   ..| ||. |||.    .|.| ... .    . |.  .| .|||||||||||.| .. | .
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

RQAKE-KKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEA
|. .. . ..|| . |.  | .| .|||.|.|. |   |||||
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 6-255 1.8e-61 203.0 In-house 48-291 (439) alignment 
Range on Protein: 6-255
Range on HMM: 48-291/439.0
NKIKNRYGNIVTYDHTRVVLKGPGGNrdGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKekchkYWPDTNQpK
.. |||| .....|||||.|.   |     | |||| ...|.  ..| |||.||| . ..||||..|...... ||||| |.|  |     |||  ..  
dqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.v

PYGQYTVSLCKNEAFADYTVRTFLVTSA--PSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKI-INESRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQ
 ||. .|   .|  . .|..| | |      .. .| . |.|.. |||| ||  |. || | . |   . .... | .|||||||||||. | .|  | |
cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq

AKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCGSTDIQAPNL
 | .. |||   |.  | .| .|||.  |||||. |||| .| | . ..  ..
lklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 6-240 3.4e-53 175.3 In-house 38-274 (287) alignment 
Range on Protein: 6-240
Range on HMM: 38-274/287.0
NKIKNRYGNIVTYDHTRVVLKGPGgnrDGRSDYINASFLQGFDGtPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQPK
.  ||||.... .|.|||.|   |   .  |||||| .. ..    ...||||||.  .  |||..|...| ......|  .| .. ||.||||. ..| 
avkknryadvlPiddtrvllsaeg...elGsdyinanyvasytd.deafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPm

PYGQYTVSLCKN-EAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKI---INE--SRHNTAPWIVHCSAGVGRTGAFIVIDAM
  | |.| | .      .|.||.. .  . ..| | . |...  ||||...  | ...||  ..   |.   .  .. | .||...|.||.| .. . ..
rvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVL
... ..   ||. . |   |  |  .||.  |. ..  |. 
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0041856 (Phosphotyrosine protein) phosphatases II 6-248 1.8e-47 156.6 In-house 1-176 (182) alignment 
Range on Protein: 6-248
Range on HMM: 1-176/182.0
NKIKNRYGNIVTYDHTRvvlkgpggnrdgRSDYINASFLQGFDGTPKkYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTgliegskekCHKYWPdtnqpk
|. |||| .|. |||.|             .|||||... |   . . .||.|||   .. ||..|........||.||         .. |||      
nldknrysdilpydhsr............dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp......

pygqytvslckneafadytvrtflvtsapSNEQRFIYQYHFTVWPDKGVPQyATAVLRFRKKIINesrhNTAPWIVHCSAGVGRTGAFIVIDAMLRQakE
                             ....| ..||... ||| |||     .|.| .....    .  | .|||||||||||...... |...  .
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl..g

KKVVDIYNYVRATRgdrPNMVQTKDQYVFIHRAVLEALVCGST
  . .....||  |   |.||.| .||.|...|.|| | .. |
vsleeavklvrsrR...pgmvitpnqyfflqlallellllkkt
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 6-242 9.9e-45 147.8 In-house 41-276 (307) alignment 
Range on Protein: 6-242
Range on HMM: 41-276/307.0
NKIKNRYGNIVTYDHTRVVLKGPGGNrdgrSDYINASFLqGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDT-NQP
|  |||| ..   |..|.|.| .|      |||| | .| |    |||.|.|||| | .  .|| |. ||.   ..||  .|| .| ||..|||    | 
ntdknryqdvkcqdkgrivvkfdgla....sdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

KPYGQY--TVSLC----KNEAFADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLrfrkKIINESRHNTAPWIVHCSAGVGRTGAFIVIDA
. .|.   |.|.     |. |  .  .    .    ... | | .. .. |||.||||   . .     ...  | .| | .|||||||||.|. . |  
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltai....nlleavrydtnpvvvhcsaGvGrsGtivaisl

MLR-QAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEA
.     . .   |. . |.  | .|.  .||. ||...|| .|| 
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 6-243 8.5e-37 121.4 In-house 55-289 (305) alignment 
Range on Protein: 6-243
Range on HMM: 55-289/305.0
NKIKNRYGNIVTYDHTRVVLKGPGgnrdgRSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQPK
.. |||| ..   |.. | |. |       |||| | ..       |..|.||||.. . |.|| || |..   ||||   .|  | || .||| ..  |
aitknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

PYGQY-----TVSLCKNEAfADYTVR-TFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFrkkiINESRHNTAPWIVHCSAGVGRTGAFIVIDAM
   .       || .|     |  .. | |  .   ...  . . ..| |||.|||    . | .    .   |    | .||||||.||||. . |. .
lelksgivvenvsgskpme.rdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslel....lsairgskvpivvhcsagigrtgtivaieyi

LRQ-AKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEAL
| . |..|..  . . |.| | .|   .|.  ||.|||| .|. .
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 6-245 1.7e-35 117.4 In-house 43-273 (288) alignment 
Range on Protein: 6-245
Range on HMM: 43-273/288.0
NKIKNRYGNIVTYDHTRVVLKgpggnrDGRSDYINASFLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTN-QP
|  ..|| |.   | ||| |.      |    ||.|  .      ... | || |..   . .|.|. ..    ||||. |.|  |||  .|.|    . 
nptrdryenlprcditrvkls......ddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

KPYGQYTVSLCKNEAFADYTVRTFLV-TSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQA
  .|..     |. |  | .|.  |.  | . .|. .. . |.  |.|.|||.   . ||. . .    .  . | .||.||||||||..|.|  .|...
arigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialesl

KEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVC
. .  . | . .   | .| . .||. ||...|| ||| |. 
rlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_CG42327_pd Subfamily CG42327 6-162 1.2e-29 98.0 In-house 28-184 (319) alignment 
Range on Protein: 6-162
Range on HMM: 28-184/319.0
NKIKNRYGNIVTYDHTRVVLKGPGgnRDGRSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTN---
 | |.|. |.|   .|||||.  |   | .. |..||...|.| .|  ||||| . | |  |||..||. .  ||| || | |   ..| .|.|  .   
skdksrvinvvPlPetrvvlqrig..dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

QPKPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRFIYQYHFtVWPDKGVPQYATAVL
. . ||.. |.| ..|.   | . |.|.     .| | .  | .  |.. .||   .|..
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaali
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 6-249 2.3e-29 97.0 In-house 52-295 (310) alignment 
Range on Protein: 6-249
Range on HMM: 52-295/310.0
NKIKNRYGNIVTYDHTRVVLKGpggNRDGRSDYINASFLQGfDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQPK
.  |||| ..|  | .|| ||    ..    ||| | ...  .   . .| .|||.. .  |||.|..|||.  |..|    |  . ||  |||     .
ymhknrysdvvcldtsrvklki...dksryedyihanyvkt.nylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte

PYGQYTVSLCkNEAFADYTVR----TFLVTSAPSNEQRF------IYQYHFTVWPDKGVPQYATAVLrfRKKIINESRHntAPWIVHCSAGVGRTGAFIV
 ||   |.   .|.  .. .     ||.    | .||        .   ..  |||.|||.     .   .... . ||   | .||||||..|... . 
tygcirvtnl.sesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv..pqrllaqvrh..gpcvvhcsagkdrlyvvva

IDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLeALVCGSTD
..  . .... . ||. . .   . .|   .||. ||..|.|  . ... | |.
lklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargete
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 6-240 7.1e-25 82.0 In-house 51-282 (302) alignment 
Range on Protein: 6-240
Range on HMM: 51-282/302.0
NKIKNRYGNIVTYDHTRVVLKGpggnrdGRSDYINASFLQGFDGTpKKYIAAQGPVEPSC---DDFWQMVWQERCSVIVMLTGLIEGSKeKCHKYWP-DT
|  ||.  ..  .|...| |..         .|.||| ..  . | .. | || |.  |    ..||.||.||..  .|.| |  | .|   ....|  .
nlkknqsedvpildsnlvklea......epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

NQPKPYGQYTVSLCKNEAFADYTvRTFLVTSAPSN--EQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAM
.. | ||.  |   | |   . .   . .   | .  .  ..  |..| |..| ||.  ... .  .|. ... . ... ..    |.|| |||..  . 
gdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

LRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVL
. . ...| . | . |.. | .||..|.. .|||....|.|
veklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_eak_pd Subfamily eak 6-166 2.1e-17 57.5 In-house 52-205 (332) alignment 
Range on Protein: 6-166
Range on HMM: 52-205/332.0
NKIKNrYGNIVTYDHTRVVLKGPGGNRDGrsdYINASFLqGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTN-QP
.  .|   .|| ||.  | |     ||.|   ||||| .  |    .||| .  . |     ||||| ...   ||.|   .|   ||  ||.||   . 
avnrn.vvkivpydrylvrltssqlnrlG...yinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

KPYGQYTVSLCKNEAFADYTVRTFLVTSapSNEQRFIYQYHFTVWPDKGVPQYATaVLRFRK
  .|.. |   .    . . .| . ..    ||   .. |..  | .  .|.|    | .||
lkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpkyed.flalrk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 6-244 2e-14 47.9 In-house 47-280 (303) alignment 
Range on Protein: 6-244
Range on HMM: 47-280/303.0
NKIKNRYGNIVTYDHTRVVLKgpggnrDgrSDYINASFLQgFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQPK
|  |||. ...  ||..| |       |  | || ||.|. .| . || | .| |.  .. |||||. ...  ....|    |  |   .  .|  ..  
nmdknrfvdvicldhskvkls......d..ssyihasyle.ld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

PYGQYTVSLC--KNEAFADYTVRTFLVTsAPSNEQRFIYQYHFTVWPDKGVPQYATAvlRFRKKII---NESR--HNTAPWIVHCSAGVGRTGAFIVID-
 . . .. .   |.  ..|  |   |   .  . . |.. .|.  || . .|  ...  .| |.|       |   .. | .    .|.||.|.| ... 
kfeersirvgefkrvelgdgwvlkvlsv.sngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet

AMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALV
| |   .|.  .|. . .   |  |   ||   |. ...  . | ..
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 6-59 1.1e-08 29.1 In-house 48-95 (95) alignment 
Range on Protein: 6-59
Range on HMM: 48-95/95.0
NKIKNRYGNIVTYDHTRVVLKgpgGNRDgrSDYINASFLQGFDGtPKKYIAAQG
|  |||. ||. || |||||     .||  |||||| |..|.    . ||||||
nipknrflnifpydatrvvlt...tkrd..sdyinacfvdgyar.kncyiaaqg
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 6-115 3.2e-06 20.1 In-house 27-107 (169) alignment 
Range on Protein: 6-115
Range on HMM: 27-107/169.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINAsflqgfdgtpkkyiaaqgpvepscddfwQMVWQERCSVIVMLtglieGSKEKCHKYWPDTNQ--
|. |||    ..  |||| |.      |  ||||||                            .|.|.   ||||.|     |  .    .||. ..  
netknrpagplapshtrvklqrv..medlgsdyina............................rmiwetnasvivvl.....gdtddknnfwpekedyq

PKPY---G-QYTVSLC
 .|    |  || || 
lhpavilgewytdsly
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 6-114 4.3e-06 19.7 In-house 26-105 (169) alignment 
Range on Protein: 6-114
Range on HMM: 26-105/169.0
NKIKNRYGNIVTYDHTRVVLKGPggNRDGRSDYINAsflqgfdgtpkkyiaaqgpvepscddfwQMVWQERCSVIVMLtglieGSKEKCHKYWPDTNQ--
|. |||    ..  |||| |.      |  ||||||                            .|.|.   ||||.|     |  .    .||. ..  
netknrpagplapshtrvklqrv..medlgsdyina............................rmiwetnasvivvl.....Gdtddknnfwpekedyq

PKPY---G-QYTVSL
 .|    |  || ||
lhpavilGewytdsl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 7-102 6.3e-23 76.0 In-house 48-154 (350) alignment 
Range on Protein: 7-102
Range on HMM: 48-154/350.0
KIKNRYGNIVTYDHTRVVLK----GPGGNRD--GRSDYINASFLQGF----DGTPK-KYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCH
  |||| ||. |.|.|| ||     . . .     .|||||..|.      .  |. ||||.|.|.    |||.... .    ||..|| ..|   |||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

KYWPDTN
.||.. .
rYWqegs
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 7-102 2.5e-14 47.4 In-house 49-157 (349) alignment 
Range on Protein: 7-102
Range on HMM: 49-157/349.0
KIKNRYGNIVTYDHTRVVLKG----PGGNRDG--------RSDYINASFLQGFDGT-PKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEK
  |||| .|. |.|.||.||     . . .            ||||| .|.    .  ||||| | |.  . |||....  ..  ... |.   | | ||
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHKYWPDTN
|..|| . .
cdiywqels
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 7-83 1.5e-09 31.9 In-house 38-116 (347) alignment 
Range on Protein: 7-83
Range on HMM: 38-116/347.0
KIKNRYGNIVTYDHTRVVLKgPGGNRDGRSD----YINASFLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVML
  |||  .    | |||||  |   . .|.|    ||||| .. || . |.|| .| |.  .  |||.||   . . .| .
lsknrskdvklidatrvvls.peksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 8-241 2.3e-47 156.0 In-house 58-281 (290) alignment 
Range on Protein: 8-241
Range on HMM: 58-281/290.0
IKNRYGNIVTYDHTRVVLKGpGgnrdGRSDYINASFLQGfdgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTN-QPKP
 |||| ..|  | |||.||  |    .  ||. | ...|   .   .| .||... .  |.|.|| ||. ..||||  |||  | ||..|.|... .   
kknrykdvvcndktrvilkd.G....ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGQYTVsLCKNEAFAD--YTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQAK
.|..|| || .|   |     .|. |    |  .  .. ..   |||| |.. . |.||  . .    |. . | .||||||.||||.|. |.. |.   
fGeitv.lcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril....rkasGpvvvhcsaGiGrtGtfvaievglqill

EKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLE
. | .|. . ||| |  | | ||   ||. . ...|.
dGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 8-244 8.5e-38 124.9 In-house 37-271 (285) alignment 
Range on Protein: 8-244
Range on HMM: 37-271/285.0
IKNRYGNIVTYDHTRVVLKgpggNRDgrSDYINASFLQGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTN-QPKP
  ||| ..   . ||||||    |.|   ||| ||...        ||..|||.  .  |||.|..||. . ..||  |.||  |||  |.|.   .   
dlnryadvrcieetrvvlk....nhd..rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGQYTVSL--CKNEAFADYTVRTFLVTSAPSNEQRFIYQYHF--TVWPDKGVPQYATAVLRFRKKiINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQ
.|.| ..|  ||.|| |   . .. |. .       .|  |     |||.  |. |  .. . |  ...   .  |  |||||||||| .|. ||    .
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykw.vkkvnpkekpicvhcsagvgrtatfvgidyatir

AKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALV
  |.  ... . ||  |  | . ||.. |..|..  ..| ..
imenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 8-93 3.3e-08 27.4 In-house 36-117 (332) alignment 
Range on Protein: 8-93
Range on HMM: 36-117/332.0
IKNRYGNIVTYDHTRVVLKgpggNRDGRSDYINASFLQGFDGTpKKYIAAQGPVEPSCDD-FWQMVWQERCSVIVMLTGLIEGSKEK
  ||   .  .||.|| |      .||. |. |||...|.      || || |..   .  ||.|| . . |.|...  . |  | |
dmnriphlycfdhsrvela....pqdgkddfynaswvdgyskk.sayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 9-245 1.7e-32 107.4 In-house 46-278 (312) alignment 
Range on Protein: 9-245
Range on HMM: 46-278/312.0
KNRYGNIVTYDHTRVVLKGpggnrDgRSDYINASFLQgFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDT------N
 ||| ||  .|  |  | |     |    || | |..     |......|||.| .|  |||..    .. |..|.|..| . ||| ||  |       .
lnrypniqcwdrgrftlag.....d.enfyihanfvk.ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

QPKPYGQYTVSLCKNEAF-ADYTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFrkkiINESRHNTAPWIVHCSAGVGRTGAFIVIDAM--
. . | .|   .          | | . |    . ..  . .| .. |||.|.|.   . ||.    .   ...  | | ||||||||||....|..|  
dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrl....lsavkkdkkpviahcsagvgrtgtlaliesmia

-LRQAKEKKVVDIYNYVratRGDRPNMVQTKDQYVFIHRAVLEALVC
 ||. . ..| |..  .   | ||   |..  |||.  |.||| | .
alrhprkqnvkdsfvll...rkdrarsvrvfpqyvyalrcvleflys
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 17-250 1.1e-17 59.1 In-house 29-257 (290) alignment 
Range on Protein: 17-250
Range on HMM: 29-257/290.0
TYDHTRVVLKGPGGNrdGRSDYINASFLQGFDGTpkKYIAAQGPVEPS-------CDDFWQMVWQERCSVIVMLTGLIEGSKE----KCHKYWPDTNQ-P
   .||||||| |      .||| |....  .|   . |. | | |           .|| |. ||.   .|||    | |..     | || |..    
LveatrvvLkgygkr..fnddyiHAnrvtcpngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee

KPYGQYTVSLCKNEAFADYTVRTFLVTSAPSNEQRfIYQYHFTVWPDKGVPQYATAVLRFRKKIinesRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQAK
  ..  ||. .. |.  |  .|. .|.    .|   .  . .  | .  |..    .|   .|.    . ...| ||||  |. |  |.  |.       
lkfkgltvkCkskekeddvetRelvvkfddeeeft.vtHsllkgWnklnvqedtktllsliqkv....kasktpvivHcvdGiSrsAalaaiilgyQkia

-EKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLealvcgstdI
  .. | . . . | |  | ...... .. |.  ...         .
etsgsvkledvlkalrkqralaitsalelafvdagiv.........l
0044763 (Phosphotyrosine protein) phosphatases II 18-239 2.8e-32 107.2 In-house 2-167 (178) alignment 
Range on Protein: 18-239
Range on HMM: 2-167/178.0
YDHTRVVLKGPggNRDGRSDYINASFLQGFdgtpkKYIAAQGPvepscDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQpkpygqytvslckn
.|.|||.|  .   .  ||||||||.  ..      |.....|      |........ ...||.||. .|. ..||..|||. .               
ldrtrvllsnl..eglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............

eafadytvrtflvtsapsneqrfiYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQakEKKVVDIYNYVRA
                        .||... .|| |||.    .|.| . | .    .  | .|||||||||.|...... |...     . .....||.
........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl..glsleeaielvre

TRgdrPnMVQTKDQYVFIHRAV
 |   | .|.. .|. ....  
rR...p.ivpnpgqlrqLyefe
0043147 (Phosphotyrosine protein) phosphatases II 33-236 5.2e-40 132.3 In-house 2-154 (172) alignment 
Range on Protein: 33-236
Range on HMM: 2-154/172.0
DGRSDYINASFLQGFDgTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLiegskekchkywpdtnqpkpygqytvslckneafadytvrtflvTS
|..|||||||.| .    |...|| |||    ..|||.|.... ...||.||.|                                            . 
degsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel............................................ly

APSNEQRFIYQYHFTVWPDKGVPqYATAVLRFRKKIIN-ESRHNTAPWIVHCSAGVGRTGAFIVIDAMLrqaKEKKVVDIYNYVRATRgdrPNMVQTKDQ
 |....|...||... ||| |||  .  .|.| . | .   . .  | .|||||||||||...... ||   .  .. .....||. |   |..||...|
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml...lglsleeavalvrekR...pgavqnpsq

YVFIH
| |..
yrfly
0046846 (Phosphotyrosine protein) phosphatases II 33-241 6.9e-40 132.0 In-house 9-171 (176) alignment 
Range on Protein: 33-241
Range on HMM: 9-171/176.0
DGRSDYINASFLQGFdgtpkKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQPKPygqytvslckneafadytvrtflvts
|. .|||||... |      ..|| |||.. .. ||..|.........|.|| ..| .. ||. |||.  ...                           
dldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

apsneqrfiyQYHFTVWPDKGVPQYaTAVLRFRKKIINESRHNtAPWIVHCSAGVGRTGAFIVIDAMLRqakeKKVVDIYNYVRATRGDRP-NMVQTKDQ
          ||... ||| |||.. ...|.. . | .  ...  | .||||||.||||...... . .    .| ..... ..  |  || ..||| .|
..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQ

YVFIHRAVLE
| |.....|.
yrflyefell
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 33-235 1.4e-32 107.7 In-house 72-273 (301) alignment 
Range on Protein: 33-235
Range on HMM: 72-273/301.0
DGRSDYINASFLQGFdGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPD-TNQPKPYGQYTVSLCKNEAFADYT--VRTFL
||.   | | ...   | |...||.|||.. ...||| |. |     ||||.  .|  .|||..| |  ...    |.... . ..|   .     ||. 
dGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtle

VTS-APSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRkKIINESrhnTAPWIVHCSAGVGRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQT
|.  .   . | .  | .. |.|.|||.  . .  .  ... .|     | .||||||.||. |||  . . |. . .. ... . ..  | .| | |||
vedstgkfatrtvthyqysewtdrgvPkshaelfdlm.elvkks...ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt

KDQYVFI
. |  ..
nsqlywm
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 35-153 1.2e-09 32.5 In-house 12-125 (130) alignment 
Range on Protein: 35-153
Range on HMM: 12-125/130.0
RSDYINASFLqGFDGTPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLtglieGSKEKCHKYWPDTNQPKPYG-QYTVSLCKNEAFADYTVRTFLVTSA
  .||||||. |  |  ..|. .| |.  .. |||.|. .    |.|.|     || |.  .||||..  . |  . .|.| . . |       . . | 
gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.....gsveeedeywpdsePlewyeediivtltdrdefknikasnleiesd

PSNEQRFIYQYHFTVWPDKG
  . .. .  .. . ||  |
lneshqaltmfqisnwpsdg
0051429 (Phosphotyrosine protein) phosphatases II 36-246 6e-53 175.5 In-house 4-227 (272) alignment 
Range on Protein: 36-246
Range on HMM: 4-227/272.0
SDYINASFLQGFdGT---PKKYIAAQGPVEPSCDDFWQMvWQERCSVIVMLTGLIEGSKEKCHKYWP-----------DTNQPKPYGQYTVSLCKNEAFA
|.||||... |. |    |.......|| . ...|||.. .......||.|... |  ..||..|||           |. ..  ||...| | . | . 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DYTVRTFLVTSA-PSNEQRFIYQYHFTVWPDKGVPQYAtaVLRFRKKIINesrhnTAPWIVHCSAGVGRTGAFIVIDAMLRQAKEKKVVD--------IY
||..|..|.|   . .| | ....|.| ||| |||| |  .|.. . . .       | .||||||..||| ..... .|..  .  .||        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

NYVRATRGDRPNMVQTKDQYVFIHRAVLEAlVCG
..|.  |  ||..||| .||.|...|.||. ...
eaveelraqrpgavqteeqylflyeallel.lrs
0036282 (Phosphotyrosine protein) phosphatases II 36-236 6.1e-44 145.1 In-house 2-163 (174) alignment 
Range on Protein: 36-236
Range on HMM: 2-163/174.0
SDYINASFLQGFDGTPkKYIAAQGPVEpscddFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDtnqpkpygqytvslckneafadytvrtflvtsAPS
|||||||.| ..  || ..|| ||| .     ||.|.........|||. ..|  ..||. |||.                                 ..
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

NEQRFIYQYHFTVWPDKGVPQYATaVLRFRKKIINESRH-NTAPWIVHCSAGVGRTGAFIVIDAMLRQAKeKKVVDIYNYVRATRGDRPNMVQTKDQYVF
 . |...||... ||| |||  .. .|.| | . .   . .  | .|||||||||||...... |||. .  ..||....||. |  ||.|||| .|| |
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IH
..
ly
0051082 (Phosphotyrosine protein) phosphatases II 36-240 4.9e-34 112.5 In-house 3-150 (151) alignment 
Range on Protein: 36-240
Range on HMM: 3-150/151.0
SDYINASFLQGFdgtpkkYIAAQGPVEpscdDFWQMVWQERCSVIVMLTGLIEGSkeKCHKYWPDTNqpkpygqytvslckneafadytvrtflvtsaps
|||||.|.. |.      ... .|| .    ||....... ...||.|... |    .|..|.|...                                 
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

neqRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINesrHNTAPWIVHCSAGVGRTGAFIVIDAMLRQakeKKVVDIYNYVRATRGdrpNMVQTKDQYVFI
   . ....... ||| |.|..  |||.| .....   ..  | .||||||.||||...... ||..     . ......|..|.   ..||...|..|.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg...vsleealeeyrlkrp...gvvqpnqqflfq

HRAVL
..|.|
lfall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 46-128 1.4e-08 28.5 In-house 228-309 (440) alignment 
Range on Protein: 46-128
Range on HMM: 228-309/440.0
GFDGTPKK--YIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEgskEKCHKYWPDTNQPKPYGQYTVSLCKNEAFADYTVRTF
 |.|  ||  .||.| |.. .  |||..| . | | |.||  | .     |  |||   .   .| .||     | .    |||.
efegyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 47-243 1.2e-21 71.5 In-house 83-288 (302) alignment 
Range on Protein: 47-243
Range on HMM: 83-288/302.0
FDGTPKKYIAAQGPVEP---SCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQP-KPYGQYTVSLCK-NEAFADYTV------RTFLVTSA--
 ||| ||   .. |. |   ... .| .. | . ...| |....|. ..|| .|. |  .    .|.|||   . .. ....|        |  ..    
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

PSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKkIInESrhNTAPWIVHCSAGVGRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYV
 .. .. .   .|. |||.| |. | . |   |    ||       .|||||||||||... |   .   ..||| |. . |   |  |   ||...| .
kkkvkktvdilafsawpdhGapkeaytaldilk.fc.es..ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

FIHRAVLEAL
..   |  .|
ylllcvtkgl
0049260 (Phosphotyrosine protein) phosphatases II 50-236 1.9e-37 123.6 In-house 7-143 (152) alignment 
Range on Protein: 50-236
Range on HMM: 7-143/152.0
TPKKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWpdtnqpkpygqytvslckneafadytvrtflvtsapsneqrfiyQYHFTVW
 |...||.||| . ...|||.|...  ...||||| | |  |.||..|.                                            ||... |
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpw

PDKGVPQYATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLrqaKEKKVVDIYNYVRATRgdrPNMVQTKDQYVFIH
|| |||. .  .| . . |    ...  | .|||||||||||...... ||   .  .. .....||. |   |..|....|. |..
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml...lgvsleeavalvrekR...pgavpnpgqlrfly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 52-236 1.5e-25 84.6 In-house 5-197 (199) alignment 
Range on Protein: 52-236
Range on HMM: 5-197/199.0
KKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQP-KPYGQYTVSLCKNEAFADYTVRTFLVTS---APSnEQRFIYQYHFT
..|||.| |.  .  |||||||.     |||.       .     ||| |.     ||  .|.     . .|||. ....|.   ||    | | .| ||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttapp.streishyqft

VWPDKGVPQYATA---VLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQAKEKK--VVDIYNYVRATRGDRPNMVQTKDQYVFIH
 | .|  |. |     |.  |.   .  . . || ||||| | | || |. .|  .|  .| |  |||...  .  |  |  .. . ..| ||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 52-236 1.5e-25 84.5 In-house 4-196 (198) alignment 
Range on Protein: 52-236
Range on HMM: 4-196/198.0
KKYIAAQGPVEPSCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQP-KPYGQYTVSLCKNEAFADYTVRTFLVTS---APSnEQRFIYQYHFT
..|||.| |.  .  |||||||.     |||.       .     ||| |.     ||  .|.     . .|||. ....|.   ||    | | .| ||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttapp.streishyqft

VWPDKGVPQYATA---VLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQAKEKK--VVDIYNYVRATRGDRPNMVQTKDQYVFIH
 | .|  |. |     |.  |.   .  . . || ||||| | | || |. .|  .|  .| |  |||...  .  |  |  .. . ..| ||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 62-244 6.6e-07 22.2 In-house 128-310 (346) alignment 
Range on Protein: 62-244
Range on HMM: 128-310/346.0
EPSCDDFWQMVWQERCSVIVMLTgLIEGSKEKCHKYWPDTNQPKpygQYTVSLCKNEAFADYTV--RTFLVTSAP-SNEQRFIYQY-HFTVWPDKGVPQY
|   .||| |..||.  .. ..    .  |.     . | |      |||  .  |.  || .   . . .   |  | .  | |  | . |     |  
esfvedfwymiyqeqihlvylmv.pddklkntttslfndenggy...qytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppk

ATAVLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALV
.  .... ...  | . ..|   |    | ||. .||     ..|  .    .|.. ... . .||  |..  ||  |.  |.. . 
tlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 64-242 1.8e-22 74.7 In-house 40-220 (255) alignment 
Range on Protein: 64-242
Range on HMM: 40-220/255.0
SCDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQPKPYgQYTVSLCKNEAFADYTVRTFLVTSAPS--NEQRFIYQYHFTVWPDKGVPQYATAV
. | |.|.. | . .|.|||. . | ..|||..|.|   . |      |...  .. ||  .||  .||  .   . . .  |... |..|  |. |  .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklk.ladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LRFRkKIINESRhntaPWIVHCSAGVGRTGAFIVIDA----MLRQAKEKKVVD--IYNYVRATRGDRPNMVQTKDQYVFIHRAVLEA
|    |.. .|.    . .||||.|.||. ||....     |.|. .. . |.    . .. .|  |.  ..|  |  |    ||. 
lnil.kvvrdsk....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_hpo-7_pd Subfamily hpo-7 65-241 5.5e-18 59.8 In-house 47-225 (263) alignment 
Range on Protein: 65-241
Range on HMM: 47-225/263.0
CDDFWQMVWQERCSVIVMLTGLIEGSKEKCHKYWPDTNQPKPyGQYTVSLCKNEAFADYTVRTFLVTSAPS--NEQRFIYQYHFTVWPDKGVPQYATAVL
 | |.|.. | . .|.|||.   | ..||| .|.|     |      |..|  ..  |  ..|  ..|  .   . . . .| .. |..|  |. |  .|
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekq.klanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

RfrkkIINESRHNtAPWIVHCSAGVGRTGAFIVIDA----MLRQAKEKKVVDI--YNYVRATRGDRPNMVQTKDQYVFIHRAVLE
.    |..  |.   . .||||.|.||. || |..     |.|. .. . |..   . .. .|  |.  ..|  |  |    ||.
n....ilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
0048076 (Phosphotyrosine protein) phosphatases II 97-240 1.5e-24 81.8 In-house 2-140 (145) alignment 
Range on Protein: 97-240
Range on HMM: 2-140/145.0
YWPDTNQPKPYGQYTVSLCKNEAFADYTVRT-FLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNtAPWIVHCSAGVGRTGAFIV
|||.   |. |     . .. | ..|. ..| . .|| .... |...||... ||| |||. .  .|.| . | .  ...  | .|||||||||||....
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

IDAMLRqaKEKKVVDIYNYVRATRgdrPNMVQTKDQYVFIHRAVL
.. ||.  .   . .....||. |   |..|.. .|. |.....|
aylmll..lgvsleealelvrsqr...pgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 117-237 2.9e-23 77.6 In-house 22-139 (144) alignment 
Range on Protein: 117-237
Range on HMM: 22-139/144.0
NEAFAD---YTVRTFLVTSAPSNEQRFIYQYHFTVWPDKGVPQYATAVLRFRKKIINESRhNTAPWIVHCSAGVGRTGAFIVIDAMLrqakEKKvVDIYN
 | ...   .|| ..  .  |  . |...||... ||| |||.... .|.| . | .  . .  | .|||||||||||...... |.    ... .....
lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lslee

YVRATRGDRPNMVQTKDQYVFIHR
 ..  |  ||..|.. .|. |...
alalvrsrrpgavpnpgqlrfLle
0038934 (Phosphotyrosine protein) phosphatases II 129-236 1.2e-08 30.4 In-house 21-170 (194) alignment 
Range on Protein: 129-236
Range on HMM: 21-170/194.0
LVTSAPSNEQR-------------------------------------------F---IYQYHFTVWPDKGV-P--QYATAVLRFRKKIINESRHNTApw
.... |...                                             |    ..|.   .||.|. |  .  .  |.. ....||. ...   
iafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv..

IVHCSAGVGRTGAFIVIDAMLRQAKekKVVDIYNYVRATRgdrPNMVQTKDQYVFIH
 ||| ||.|||| ...   . |.    .. . ....|  |   |..... |..  ..
aVHCkaGlgRtGtlvaaYLiyrlgm..saeeAialfrekR...pgaipnqdyleall
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 130-240 1.5e-14 48.5 In-house 207-341 (350) alignment 
Range on Protein: 130-240
Range on HMM: 207-341/350.0
VTSAPSNEQRfIYQYHFTVWPDKG---VPQYATAVLRFRKKIINES-------RHNTAPWIVHCSAGVGRTGAFIVIDAMLRQ-------AKEK------
.| |.|.    .|| ..  |.| .    |.    .|  ....|..          ...| .||||||||||| .. .| .| .        ||       
itlaasdPyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldva

-KVVD-IYNYVRATRGDRPNMVQTKDQYVFIHRAVL
 |. | |   |   |  | .|||..||..||. |.|
aktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 137-280 1.8e-34 113.8 In-house 87-231 (440) alignment 
Range on Protein: 137-280
Range on HMM: 87-231/440.0
EQRFIYQYHFTVWPDKGVPQYATAVLRFRKKiINESRH--NTAPWIVHCSAGVGRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVF
| | . |||.  |||||||..|  ||.. .  .|||..    .| .||||||.||||  |..|..||.||    .||.... . | .||.|||| .||.|
esrtlkqyhyqgwpdkgvpkfagpvlkmiqd.vnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IHRAVLEALVCGSTDIQAPNLRNVMTKLEKIRPREQVSGYESEFQR
.| ||||.|.|| | |   .. . . ...   |. . |  . ||. 
vheavlegllcgdtliledditerveqiqwpnphtdksplqqefeg
subfamily_PTPDC1_pd Subfamily PTPDC1 139-236 7e-08 27.1 In-house 81-169 (182) alignment 
Range on Protein: 139-236
Range on HMM: 81-169/182.0
RFIYQYHFTvWPDKGVPQYATaVLRFRkKIINESRHNTaPWIVHCSAGVGRTGAFIVidAMLRQAKEkkvVDIYNYVRATRGDRPNMVQTKDQYVFIH
. || | |. |.| ||.   . .|    |... . ..     ||| || ||||  |   ..|  ||.   ..  . ..  |  ||. .||..|  ...
qgiyvynfg.wkDygvasler.iLdiv.kvvafalqeg.kvavhChaGlGrtGvlia..cylvyakr...ltaekaiklvrskrpksiqtreqvelvk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 140-240 1.2e-08 28.7 In-house 219-341 (349) alignment 
Range on Protein: 140-240
Range on HMM: 219-341/349.0
FIYQYHFTVWPDKGV---PQYATAVLRFRKKIINES-------RHNTAPWIVHCSAGVGRTGAFIVIDAMLR--QAKEKKV----------VDIYNYVRA
 ..|  .  |.| ..   |.     |  ....|..          .... .|||||| |||| .. .| .|   .  ...             |.  |  
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

TRGDRPNMVQTKDQYVFIHRAVL
 |  | .|||   |...|. |.|
lrkqrismvqnlaqfiaiyealL
PTPc_DSPc_SM00012 141-241 2.8e-33 109.6 In-house 2-105 (105) alignment 
Range on Protein: 141-241
Range on HMM: 2-105/105.0
IYQYHFTVWPDKGVPQYATAVLRFRKKIINESRHNT--APWIVHCSAGVGRTGAFIVIDAMLRQAKEK-KVVDIYNYVRATRGDRPNMVQTKDQYVFIHR
...||.| |||.|||......|.. ... .. ....  .| .||||||||||| |...| .|.| ... | |||...|.. |  ||.||||..||.|..|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
PTEN_1 143-225 3.4e-06 22.0 In-house 96-178 (196) alignment 
Range on Protein: 143-225
Range on HMM: 96-178/196.0
QYHFTVWPDKGVPQYAtAVLRFRKKIINESR-HN-TAPWIVHCSAGVGRTGafIVIDAMLRQAKEKKVVDIYNYVRATR-GDRPNM
.|.   ..| |.|  .  .... |..|.  . ..     .||| ||.||.|   |. | | ...   . .   .||. |   .||.
eylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsG..tvvaayLmykgkltadeAlelvrekRppgapns
DSPc Dual specificity phosphatase, catalytic domain 161-224 9.7e-07 23.7 Pfam-A 58-120 (133) alignment 
Range on Protein: 161-224
Range on HMM: 58-120/133.0
VLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMlrQAKEKKVVDIYNYVRATRGD-RPN
 |.  ...|.. . .    .||| ||. |....|.   |  . |. .. . |..|.  |.  .||
eleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm..ktknlslneAyefvkerrskispn
DSPc Dual specificity phosphatase, catalytic domain 161-224 9.7e-07 23.7 In-house 58-120 (133) alignment 
Range on Protein: 161-224
Range on HMM: 58-120/133.0
VLRFRKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMlrQAKEKKVVDIYNYVRATRGD-RPN
 |.  ...|.. . .    .||| ||. |....|.   |  . |. .. . |..|.  |.  .||
eleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm..ktknlslneAyefvkerrskispn
PTPc_motif_SM00404 165-222 2.6e-07 25.6 In-house 69-125 (140) alignment 
Range on Protein: 165-222
Range on HMM: 69-125/140.0
RKKIINESRHNTAPWIVHCSAGVGRTGAFIVIDAMlrQAKEKKVVDIYNYVRATRGD-R
 ...|.... .    .||| ||| |....|.   |  . .. .. . |..|.  |   .
vldfienaekkggkvlVHCqaGvSRSatliiaYlm..ryrqlslaeayefvkerRpiis
subfamily_DSP19_pd Subfamily DSP19 166-224 8.4e-07 23.4 In-house 79-136 (152) alignment 
Range on Protein: 166-224
Range on HMM: 79-136/152.0
KKIINESRHNTAPWIVHCSAGVGRTGAfIVIDAMLRqAKEKKVVDIYNYVRATR-GDRPN
 . |.|.|..    .|||.||| |. . .||  ...  .|... . ...||..|   .||
ldFieearskdgavlvHCnAGvSRsas.vviaylmk.keelsleealelvrearpcikPn
subfamily_DSP6_pd Subfamily DSP6 167-221 8.4e-06 19.4 In-house 84-136 (158) alignment 
Range on Protein: 167-221
Range on HMM: 84-136/158.0
KIINESRHNTAPWIVHCSAGVGRTGAFIVidAMLRQAKEKKVVDIYNYVRATRGD
. |.|.|.. .  .||| ||. |. . ..  | | . ..  . | |..|.. . .
efidearskkskvlvhClaGisrsvtvtl..aylmkklalslndaydlvkkrksn
subfamily_DSP10_pd Subfamily DSP10 168-220 9.9e-07 22.8 In-house 84-134 (159) alignment 
Range on Protein: 168-220
Range on HMM: 84-134/159.0
IINESRHNTAPWIVHCSAGVGRTGAFIVidAMLRQAKEKKVVDIYNYVRATRG
 |.| |.. .  .||| ||. |  ....  | | . .. .. | |..|. .| 
fieearkkgsrvLvhCqaGisrsatvvi..aYlmkhlnlslndaykfvkekrp
subfamily_CG42327_pd Subfamily CG42327 172-239 4e-16 53.6 In-house 243-311 (319) alignment 
Range on Protein: 172-239
Range on HMM: 243-311/319.0
SRHNTAPWIVHCSAGVGRTGAFIVIDAMLRQAKEK-KVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAV
 |..  | .|||| ||||||  |  |  .|. .|  . ||| . |   | || . |.||.|| ||.. .
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 176-243 6.1e-15 49.9 In-house 228-295 (297) alignment 
Range on Protein: 176-243
Range on HMM: 228-295/297.0
TAPWIVHCSAGVGRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEAL
 |. .|||||||||.|  .  |..| . . |.. |.   ..  |  |. .||| .|. ... |||. |
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_eak_pd Subfamily eak 176-245 2.4e-07 24.5 In-house 237-307 (332) alignment 
Range on Protein: 176-245
Range on HMM: 237-307/332.0
TAPwIVHCSAGVGRTGAFIVIDAMLRQ--AKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVC
 || |. .. |  |.|.|.||| ..|   .| | .  . ...   .  |   | .. |. ||. .||. |  
fap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 180-246 3.4e-19 63.0 In-house 2-68 (69) alignment 
Range on Protein: 180-246
Range on HMM: 2-68/69.0
IVHCSAGVGRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCG
.||||.| ||||.|| |   . . | .|.|||.| |.  |  || ||  . .|.||| |. |||  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 180-246 8.3e-19 61.7 In-house 1-67 (69) alignment 
Range on Protein: 180-246
Range on HMM: 1-67/69.0
IVHCSAGVGRTGAFIVIDAMLRQAKEKKVVDIYNYVRATRGDRPNMVQTKDQYVFIHRAVLEALVCG
.||||.| ||||.|| |   . . | .|.|||.| |.  |  || ||  ...|.||| |. |||  |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 246-536 6.6e-105 345.6 In-house 1-292 (298) alignment 
Range on Protein: 246-536
Range on HMM: 1-292/298.0
GSTDIQAPNLRNVMTKLEKIRPREQVSGYESEFQRLSIFWL-SPDVRVESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERN
|.|.|.|..|.. ..||..........||..|||||.      ..   | |..  | .|||..||..||| || |. ..|.|  .|||||||.|||..||
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLe.kedadeesdYiNAsflhaykgrn

AFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDE-HFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHS
|||.|||||. |.. |||||...| ||||||..| | |. ....|||..|.|.|| |.|.|....... .|.|.. .. | ... ........|.|.|..
afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkg

VPDKPLDLLPLLNDIQTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLDS
|| .   .| ||.....|||..|.|...||||.||||||| .|| ||.|||| |.||||||.|| ||..|||||.| |||.|.|...| .|||
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
0051299 (Phosphotyrosine protein) phosphatases II 247-534 5.1e-82 270.9 In-house 2-286 (288) alignment 
Range on Protein: 247-534
Range on HMM: 2-286/288.0
STDIQAPNLRNVMTKLEkirpREQVSGYESEFQRLSIFWLSpdVRVESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAF
.|.|.. .|.... ||     . ...|.. ||..|  .. .  . . .|.. .| .|||..||||.|. || |. ..|...| ||||||. . |.  ..|
dteisveellklvlkll....angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLs.vldgvegsdYinAsyidgynlkrkf

ILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTK----GKSTPQRICHFQVTNWSD
|.||.||..|...||||| ...  .||||..|.| . | ...|||..| ..|| |.|.| .|. .. .. | . .| .    |....... ||..||| |
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpd

HSVPDKPLDLLPLLNDIQTSQQkSGDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
|.||| | .|| .|........ ||.. .|| ||.||||.||..|.  ..|... |..|||..||| ||  |||.|.|.|||.|.|.. | ||
hgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 248-535 3e-59 195.5 In-house 2-298 (306) alignment 
Range on Protein: 248-535
Range on HMM: 2-298/306.0
TDIQAPNLRNVMTKLEKIRPREQVSGYESEFQRLSIFWLSPDVRVESASRACNASKNRFPDILPLDSHRVALHlsVDKDPGADYINASFAH--AYRERNA
|.. | .... ...||| . . . .|.| ||..|.    .  .  . .... |..|||.  ||| |  || |.   .. ||.|||||.. .  .  ....
tsllakeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdks

FILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWPSQGA-EEYGGIKVELQEEDDKSFFISRRFDIT-TKGKSTPQRICHFQVTNWSDH
.| ||  ||.|.. |||||.. .   |||.    |   |.  ||||.. . |||| |.|.  .|.... .| |.. .. .| |.. ... ... ..| ||
yiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdh

SVPDKPLDLLPLLNDIQTSQQKSG---DKAIVVQCSDGVGRSGTLCAI---MSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLD
.|| .|  .| .|.|... |...      .||| ||.|.|| ||.  |   ...||. ...  .|. ..|| .|  | | | | .|||| | .  .|..
gvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
0039614 (Phosphotyrosine protein) phosphatases II 258-534 1.8e-77 256.0 In-house 18-289 (297) alignment 
Range on Protein: 258-534
Range on HMM: 18-289/297.0
VMTKLEKIRPREQVSGYESEFQRLSIFWLSpdvrVESASRACNASKNRFPDILPLDSHRVALHLSVDKDPGADYINASFAHAYRE-RNAFILTQAPLEDT
|.. | ..... . .... ||..|  .  .     . | . .| .|||..||||.|..|| |.   . |.. ||||||.   |.   ..||.||.||..|
vldlllllekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

IASFWRMVVDYDLGTIVMLNSLDEEDEHFPRYWPSQGAeEYGGIKVELQEEDDKSFFISRRFDITTkgKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLN
...||||| ...  .||||..|.| . ....|||. |  .||...|.| ... .. .. | . .|   .. .  . |||.|.| ||.||. . .|| .|.
vedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefle

DIQTSQQKS-GDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
 ... .... ... ..| ||.||||.||..|.  ..|... |. |||..||| ||  |||||.|..||.|.||. | .|
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0045450 (Phosphotyrosine protein) phosphatases II 260-533 3e-75 249.1 In-house 15-303 (307) alignment 
Range on Protein: 260-533
Range on HMM: 15-303/307.0
TKLEKIRPREQVSGYESEFQRLSIFWLSPDVRVESASRACNASKNRFPDILPLDSHRVALHLSVDKDPGADYINASFA--------HAYRERNAFILTQA
 .| ...... ..|.. ||..|  ..  .    ..|.. .| .|||..||||.|..|| |.   ..... ||||||.         . |.  ..||.||.
lllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWPSQGAE-EYGGIKVELQEEDDKSFFISRRFDITTK-GKSTPQRICHFQVTNWSDHSVPDKP
||..|...||||. ... ..||||..|.|  .|  ..|||. | | .|| ..|.| .|. .. .. |.. .| . |.. . ...||. |.| ||.||. .
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsf

LDLLPLLNDIQTSQQKS-GDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHV---VDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
 .|| ... ... .... ... ..| ||.||||.||..|.  ...... |..   ||...||| ||  |||||...|||.|.|.. | .
eelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0050432 (Phosphotyrosine protein) phosphatases II 261-534 8.4e-83 273.5 In-house 31-299 (308) alignment 
Range on Protein: 261-534
Range on HMM: 31-299/308.0
KLEKIRPREQVSGYESEFQRLSIFWLspDVRVESASRACNASKNRFPDILPLDSHRVALhlsvdkDPGADYINASFAHAY--RERNAFILTQAPLEDTIA
 |... .  . ...| ||..|  .    .   ..|.. .| .|||..||||.|. || |      |.| ||||||. . |  . ...||.||.||..|..
llkllekaldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqgPlpntve

SFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWPSQ---GAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPL
.||||| ...  .||||..|.| . | ...|||.    | .|||...|.| .|. .. .. | . .| .|..   .. ||. ||| ||.||..| .|| .
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldf

LNDIQTSQqksGDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
|. ...|.   ... ||| ||.||||.||..|.  ..|... |. ||||.||| ||  |||.|.|.|||.|.|.. | ||
lelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 265-533 1e-67 223.4 In-house 15-285 (307) alignment 
Range on Protein: 265-533
Range on HMM: 15-285/307.0
IRPREQVSGYESEFQRLSIFwlSPDVRVESASRACNASKNRFPDILPLDSHRVALHLsVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMV
 | |.   |.. |...|       |   . . .  || |||..|| . |..|| |.  .  .  .||||||| ..|.|.. ||  |.|.| ||  ||||.
srkrdtdfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkk.ingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

VDYDLGTIVMLNSLDEEDE-HFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKST-----PQRICHFQVTNWSDHSVPDKPLDLLPLLNDI
 . .. .||||  |.| .. . ..||| .   .|| | |.| .|. .| .| | .|...|....      ...  .. |.| |  ||. .  || |.. .
aeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqv

QTSQQKSgDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
.  ....    ||| || ||||||.. |. |.....| |. ||.|. ||.||  |.  |. ||||.|.|   | |
relykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 266-532 1.9e-71 235.4 In-house 15-277 (288) alignment 
Range on Protein: 266-532
Range on HMM: 15-277/288.0
RPREQVSGYESEFQRLSIfwLSPDVRVESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVV
  ... .|...|.. |.   |  .  |. ...| ||.|||...|||.| .|| |.  ... .||||||||. . .......| ||.|| ||.  ||..| 
ksarnrtgfseeynsLaa..lektksvtagrlavnakknRyrnilpyDekrvklk.kleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvy

DYDLGTIVMLNSL-DEEDEHFPRYWPSQGA-EEYGGIKVELQEEDDKSFFISRRFDITtkGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQ
...  |||||..| ......  .|||...  ..|| ..|.|.|. ..  |. |.. .    | |  .| ..| . |.||.||.   .|| ||. .....|
enktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

KSgDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLA
.   . |.|.||.||||.||  |.  .|..|. | ..||. .|..|| .|.  |.||.|| |.|.| | 
ad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 266-535 4.3e-57 188.4 In-house 9-277 (281) alignment 
Range on Protein: 266-535
Range on HMM: 9-277/281.0
RPREQVSGYESEFQRLSIfwLSPDVRVESASRACNASKNRFPDILPLDSHRVALHLSvDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVV
. ... .|. .|.. |.   .  |   ... .  |  |||. .|   |  || .. . ...  .|||||.|  .|.. ...| ||.|. .....||.||.
lsqndnaGfieeyeklaa..igvdntataskadenvlknrYsnivaYDatrvkvtpn.eenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvw

DYDLGTIVMLN-SLDEEDEHFPRYWPSQG-AEEYGGIKVELQEEDDKSFFISRRFDItTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQ
...  .|||.   ....  .  |||| .  . .|| ..|. ..| .|. .|.|.| . .. .. .... ... |.| || ||... .||   ....  ..
eqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklte

KSGDKAIVVQCSDGVGRSGTLCAIMSVIERVKVE-HVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLD
|. . ..|. || ||||.||  |.  ....|. | . .|| . |..|| .|   | |. ||.| | . | .||
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0036941 (Phosphotyrosine protein) phosphatases II 269-534 1.9e-77 255.8 In-house 10-277 (297) alignment 
Range on Protein: 269-534
Range on HMM: 10-277/297.0
EQVSGYESEFQRLsiFWLSPDVRVESASRACNASKNRFPDILPLDSHRVALhlsvdKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYD
 . .....||..|  . | ..   . |.. .| .|||..||||.|. || |     .|.| ||||||.   |.  ..||.||.||..|...||||| ...
lflalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

LGTIVMLNSLDEE-DEHFPRYWPSQ--GAEEYGGIKVELQEEDD--KSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQ
  .||||..|.|   | ...|||.   .  .||...|.|....   .. .. | . .| .|.. . .. ||..|.| ||.||. | .|| ... ... ..
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

KS-GDKAIVVQCSDGVGRSGTLCAIMSVIERVK---VEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
.. ... ..| ||.|||||||..|.  ......    |. ||...||| ||  |||||.|||||.|.|.. | .|
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 270-534 2.6e-76 252.0 In-house 10-272 (273) alignment 
Range on Protein: 270-534
Range on HMM: 10-272/273.0
QVSGYESEFQRLsiFWLSPDVRVESASRACNASKNRFPDILPLDSHRVALhlsvdKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDL
...... ||..|  . | |..  . |.. .| .|||..||||.|. || |     .|.| ||||||.   |.  ..||.||.||..|...||||| ... 
gltllleefell..lslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

GTIVMLNSLDEE-DEHFPRYWPSQG---AEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKS
 .||||..|.|   | ...|||. |    ..|| ..|.| .|. |. .. | . .| .| . .  ..||..|.| ||.||. . .|| ....... ....
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-GDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
 ... .|| ||.||||.||..|.  ...... |. |||..||| ||  |||.|.|.|||.|.|.. | ||
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 271-536 1.3e-68 226.0 In-house 19-285 (290) alignment 
Range on Protein: 271-536
Range on HMM: 19-285/290.0
VSGYESEFQRLSIFWLSPDVRVEsaSRACNASKNRFPDILPLDSHRVALH-LSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDL
 .|....|..|  .  .  | |.      |  .||| .|.. | .|. |. .| .||   .||||.. . |.|....|.||.|...|.. ||..... . 
negfrnqfkmldsgesehtvtvg..ltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekv

GTIVMLNSLDEEDE-HFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGK-STPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGD
  |||| .  ||.. .   |||......|| ....|..|   . .| |..... | .  ..| . ..|.||| ..    .|   | ... ..  | |.|.
tiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgn

KAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLDS
..||| |||.||||...||..  |...| | |.|||| .|..|| .|| |.| .||.. ... | ||||
tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0043336 (Phosphotyrosine protein) phosphatases II 272-533 2e-74 245.9 In-house 20-276 (278) alignment 
Range on Protein: 272-533
Range on HMM: 20-276/278.0
SGYESEFQRLSIFWLspdVRVESASRACNASKNRFPDILPLDSHRVALHLsVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGT
.... ||..|  |.|      . | . .| .|||..||||.|..|| |.| ...|.. ||||||.   |.  ..||.||.||..|.. ||||| ...  |
tllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsl.lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMLNSLDEED-EHFPRYWPsQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQkSGDKAI
||||..|.| . . . .||| .| ..||...|.|..|. .. .. | . .| .|.. .. ..|.. ..| ||.||. . .|| .|..... .. . ....
ivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpv

VVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
.| ||.||||.||..|.  ..|... |. ||...||| ||  |||||.|..||.|.|.. | |
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 272-534 6e-73 240.7 In-house 22-283 (305) alignment 
Range on Protein: 272-534
Range on HMM: 22-283/305.0
SGYESEFQRLSIFwlSPDVRVEsaSRACNASKNRFPDILPLDSHRVALHLSVDKDpGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGT
.|.| ... |     .  . |.  ..  |..|||. .| .|| .|. |  . ..|  .||||||. ..|......|..|.||..|.| |||..|..   |
kgleaqykslyee..eesidvg..kkeankaknrlkeitlldddriiltekesld.dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvst

IVMLNSLDEEDEH-FPRYWPSQGAE--EYGGIKVELQEEDDKSFFISRRFDITT-KGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGD
||||  | |....   .||| . .|  |.| ..|||..|   | .| |.. |.. ....  . . ..|.|.| || ||...  || |....| .|.|. .
ivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

KAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
....| ||.||||.|. .|.   .||.| | |||||. .|.|| .|...|.||.|| |..|.   ..
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 272-536 1.9e-64 212.4 In-house 20-280 (287) alignment 
Range on Protein: 272-536
Range on HMM: 20-280/287.0
SGYESEFQRLSIFWLSPDVRVESASrACNASKNRFPDILPLDSHRVALHlsvdkDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGT
 |..  |. |     ..|    . .   |  |||. .||. | .|| |.     .   |||||.|  .|.|..|||....|. .|.  ||... |    .
egfknqftvleqvtqredevthnia.sqnkdknRltqilvpdnyrvllk.....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvta

IVMLNSLDEEDEH-FPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGK-STPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDKA
||||  . |.||.   .|||.. .  .|  ..|| .|. .. .| |..... |.| ...|..  .|.||| ..    .|   | ....   .|.|.|. .
ivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnts

IVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLDS
||| |||.||||...||.   |...| | |.|||| .|. || .||.| | ||||| .|. |.||||
ivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPRG_pd Subfamily PTPRG 272-533 3.9e-64 211.8 In-house 19-286 (563) alignment 
Range on Protein: 272-533
Range on HMM: 19-286/563.0
SGYESEFQRLSIFWLSPDVRVESASRACNASKNRFPDILPLDSHRVALHLSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGT
 |.. ||. |     | |. .|.... .|  |||  .|.. |. || |.   .|.   |||||.. . |.  .||| || ||.||.  ||||. .    .
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVMLNSLDEE-DEHFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITT----KGKS--TPQRICHFQVTNWSDHSVPDKPLdllPLLNDIQTSQQK
|||.  | |.  .. ..|||....|.|| ..| |.||. ..   .|.. |      |.|.  | ... ... |.| ||.||...|   | |. .. |.. 
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl...pvLifvkkssaa

SGD--KAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
  .    ||| || ||||.||.... ....... |..|.||. .| .|  |.  |.| ||| | .|. |  
nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_PTPRB_pd Subfamily PTPRB 272-534 9.3e-61 200.4 In-house 25-285 (293) alignment 
Range on Protein: 272-534
Range on HMM: 25-285/293.0
SGYESEFQRLSIfwLSPDVRVESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGT
 ..  |...|.   .  |  |..|..|.|..|||. .||| |  || |. ......|.|||||.. . |. .. || || || .|.  ||||| .    .
lrfseeyeelka..vgkdqavkaaelavnraknrytnilpydhsrvkLa.alkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

IVMLNSLDEEDE-HFPRYWPSQ-GAEEYGGIKVELQEEDDKSFFISRRFDITTkgKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQ-QKSGDK
||||  | |.   .  .|||..  .  || |||.|..|.... .. | . |.   ... ... ... | |.|| ||.|.  || ... ..... ... ..
ivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

AIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
 ||| || ||||.||. |.  ...... | .||.|  | .|| .|   | | .|| | ... |..|
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPN23_pd Subfamily PTPN23 272-533 3.4e-56 185.2 In-house 15-279 (288) alignment 
Range on Protein: 272-533
Range on HMM: 15-279/288.0
SGYESEFQRLSIFWLSpDVRVES-ASRACNASKNRFPDILPLDSHRVALHlsVDKDpgaDYINASFAHAYRE-RNAFILTQAPLEDTIASFWRMVVDYDL
.. . .|. |       . |  | |   ....|||. |||| |. || |.    ||   ||||||| .        || |||||. |.. ||.||..   
taldkkfkeleqkqdk.earkrsiaiaklyseknrsrdilPyDhnRvklr..gskD...DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

GTIVMLNSLDEEDEH-FPRYWPSQG--AEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQT---SQQ
 .|||| | .| ...   ||||..   ....| ..| |... . . .. | . ..|..... . ..| |.|.|... ||. | .|| .|. ...   ..|
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavq

KSGDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEH-VVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
.  .. .||.|| ||||.|... ...... ..... ..|. | |. ||  |   |.. ||.||.|.. | .
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 273-534 5.2e-25 82.8 In-house 23-287 (305) alignment 
Range on Protein: 273-534
Range on HMM: 23-287/305.0
GYESEFQRLSIFWlsPDVRVESASRACNASKNRFPDILPLDSHRVALHLSVDkdpgADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTI
|  .||. .  |      ....   | .| |||. |.  ||  || |. .       .|| | .  .  . . || ||||||.| | || | ..  . .|
glraefvamkrfn..dfekmkafkeaqeagknrykdvgcldnnrvklegpwp....heyihanyvstptnpkrfictqaplektcadfwymclqdkveai

VMLNSLDEE-DEHFPRYWPSQGAEE----YGGIKVELQEEDDKS--FFISRR-----FDITTKGKS-TPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQ
 ||  | |   ..   |..|.  ..     .| |. .. |  ..  |  . .       .. .|   . ... |.   .| |  ||   | .| ||.. .
fmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar

TSQqksGdkAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVD-VFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
.|.   |   ||| || |.||.|..  .  .....   ....   . .. .|  |  ...| .|| | ..| | |.
psk...g..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 274-535 1.9e-78 258.8 In-house 25-284 (319) alignment 
Range on Protein: 274-535
Range on HMM: 25-284/319.0
YESEFQRLSIFWLSpdvRVESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIV
 | ||. |..        ..|||.  | .|||...||. |  ||.|  ..|  .|.|||||||  .|.||..|| ||||||.||  ||||| ...  ..|
lekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvls.eldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivv

MLNSLDEEDE-HFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKST-PQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDKAIV
||. | |. . .. .|||..  |||| . |.|.||. .. .| |.. . .|       .. ||| |.|.|| ||.| . || ||..|. |..|. .. ||
mltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPiv

VQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLD
| ||.|||| || ...  ..|||| | |.|||. |..||. |.  |.. |||||.|.. |....
vhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 274-530 1.5e-58 193.6 In-house 36-287 (319) alignment 
Range on Protein: 274-530
Range on HMM: 36-287/319.0
YESEFQRLSIFWlSPDVRVESASRACNASKNRFPDILPLDSHRVALHLsVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIV
.| ||.|..     .    . |    |  |||. .||. |  .| |.  ..   ..|||||||   |. .. .| .| ||..|.| ||||. .|.  |||
levefrracklg.vnladqtfanldqnkdknriinilafdknvvkler.liGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLNsldeeDEHFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQR-ICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQ-KSGDKAIV
.|       ..  .||| .. ....  ||...  .. . .. | .... .|| . .| |  |    | |. ||| | ||. |.. ..  .. . . . ||
llt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhraniv

VQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVT
| || ||||.|.  ..  ...|.| |. |||.. |..||  |.  |. | ||||.|   
vhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
0046845 (Phosphotyrosine protein) phosphatases II 275-534 1.1e-79 263.1 In-house 3-274 (284) alignment 
Range on Protein: 275-534
Range on HMM: 3-274/284.0
ESEFQRLSIFWLSPDVRVESASRACNASKNRFPDILPLDSHRVALHLSVDKDPGADYINASFAHAY-----RERNAFILTQAPLEDTIASFWRMVVDYDL
| ||..|  .. .. . .. | . .| ||||..||||.|. || |.   ..... ||||||. . |     . ...||.||.||..|...||||| ... 
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnv

GTIVMLNSLDEED-EHFPRYWPSQG-AEEYGGIKVELQEEDDKSFFISRRFDITTKG-KSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQK-S
 .||||..|.| . | ...|||. |   .||...|.| .|. |. .. |.. .| .| .. . .. ||..|.| ||.||. | ||| .|......... .
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

GDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEH---VVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
|.. ||| ||.||||.||..|.. ..|... |.   .|||..||| ||  |||.|.|||||.|.|.. | ||
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 276-536 5.4e-76 250.7 In-house 24-282 (318) alignment 
Range on Protein: 276-536
Range on HMM: 24-282/318.0
SEFQRLSIFWlSPDVRVESaSRACNASKNRFPDILPLDSHRVALHLSVdKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVML
.|..|||    .   ...|    .|. |||. .||. |. ||.|.  . ...|.|||||..   ||...|.| .|||| .||  ||||| . .  .||||
eeyerlsrse.etvtslks.lepvnkaknryanilaydhtrvkLqmle.geegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml

NSLDEED-EHFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDKAIVVQC
  . |.  .   |||||.|...|| ..|||.|| . | .. |.| .| ....  . .  ...|.|.|..||... .|| |. .... ||||| ..||| |
tqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC

SDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLDS
| |||| |. .|. ...||.| | .||||| ||.||  |.  | | .||.|.||| | .| |
saGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 276-533 1.5e-37 124.0 In-house 14-276 (287) alignment 
Range on Protein: 276-533
Range on HMM: 14-276/287.0
SEFQRLSIFWLSPDVRVESASRACNASKNRFPDILPLDSHRVAlhLSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVML
 |...|     |  .   .|    ...|||. |.||.|  ||   || . . |.||||| .  .|.. .||| .|.|.  |. .|||.|..    .....
kevdalkedsesstatfkaaeelaavkknryadvlPiddtrvl..lsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm

-NSLDEEDEHFPRYWPSQGA-EEYGGIKVELQEEDDKSF-FISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDI----QTSQQKSGDK
   ..|   .  .||| .      ||  | | . | |.  .  | . .        . .  ... .| |....   . |. .  |.    . ... |.  
treveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevG

AIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
 .|| .. |.||||.| |.. ...| .    ||| ..|  ||  | . | .  |... |.   .|
PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 276-534 2.9e-29 97.0 In-house 20-277 (307) alignment 
Range on Protein: 276-534
Range on HMM: 20-277/307.0
SEFQRLSIfWlSPD-VRVESASraCNASKNRFPDILPLDSHRVALHLSvdkDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVM
 ||. |.  . .|. | ||. |  .|. |||. |.   |  |. ....      .||| | .     . . || .| |||.|. ||| |... .. ...|
defrvlak.k.tpegvtveafs..antdknryqdvkcqdkgrivvkfd...glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LNSL-DEEDEHFPRYWPSQ-GAE-EYG----GIKVEL----QEEDDKSFFISRRFDITTKGKStpQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQq
|  . .    .  .||| . | .  .|     | |.     .   |. .     ...   .||  . | |.| .|| |. ||.  |  . ||. ..  . 
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqks..rtiqhlqwenwpdrgvpqinltainlleavrydt.

ksgdKAIVVQCSDGVGRSGTLCAIMSVIER-VKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
      .|| || |||||||. ||  | .. .. .   |. . |..||  |. |..|  || . . | | |.
....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0040438 (Phosphotyrosine protein) phosphatases II 277-534 1.6e-77 256.2 In-house 23-276 (317) alignment 
Range on Protein: 277-534
Range on HMM: 23-276/317.0
EFQRLSIFwlSPDvRVESASRACNASKNRFPDILPLDSHRVALhLSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLN
||..|  .  ..|   . |.. .| .|||.|||||.|. || |  ....|.. ||||||. . ......||.||.||..|...||||| ......||||.
efedllsl..kld.tysvaelpenkdknrypdilpydhsRVkL.splggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

SLDEE-DEHFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQkSGDKAIVVQCS
.|.|  .| . .|||...  .||...|.|..|. .. .. |.. .. .|.|.. .. ||. |.| ||.||. | .|| .|. ...... .... ..| ||
eleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCs

DGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
.||||.||..|.  ..|... |. |||..||| ||  |||||.|.|||.|.||. | ||
aGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_PTPN13_pd Subfamily PTPN13 277-535 7.7e-50 164.7 In-house 16-270 (273) alignment 
Range on Protein: 277-535
Range on HMM: 16-270/273.0
EFQRLSifWLSPDVRVESASRACNASKNRFPDILPLDSHRVALHLSVDkdpgadYINASFAHAYR--ERNAFILTQAPLEDTIASFWRMVVDYDLGTIVM
||. |    | |  ..|.. .. | .|||. ..|| |  || |  .        |||||. ..    ..  .|..| || .|.. ||.|| . .   |.|
efkelr..elkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LNSlDEEDEH--FPRYWPSQGAEE---YGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQksGDKA
. . . |...    ||||..  ..   .. ..||| .  ... |  |.. .. .  .  ... |.. ..| ||.|| ....|| ..  ... |.      
vtl.ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagP

IVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLD
||| || |.|||||| .|  |.. .. .. .|| . |..||  | | | | .|| |.| ..|  | 
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 278-531 1e-58 193.5 In-house 15-263 (283) alignment 
Range on Protein: 278-531
Range on HMM: 15-263/283.0
FQRLSIfwlsPDVRVESASRACNASKNRFPDILPLDSHRVALHLSVDkdpgaDYINASFAH---AYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVM
..|||.    ||  .. ||   |  |||. .|.| | .|| |.         |||||.|      |.. . .| .|.||..|.  ||.|| | .  .|||
lkrlsv....pdldadiasadenkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm

LNSLDEED-EHFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTK--GKSTPQrICHFQVTNWSDHsVPDKPLDLLPLLNDIQTSQQKSGDKAIV
|  | |.  ..  .|||..|.|.||   | |..|  .  || . . . ..   |||   ..|.|| .| .   .. ... |  .| ... |..| .  ||
ltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWley.geqaiinslvkfnkvislqteskkgPiv

VQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTL
| || |.||.....|... .. .. | |||||. ||..|  |..|| ||.|||. ... |
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
0045098 (Phosphotyrosine protein) phosphatases II 281-533 1.8e-69 229.5 In-house 14-271 (278) alignment 
Range on Protein: 281-533
Range on HMM: 14-271/278.0
LSIFWLSPDVRVESASRACNASKNRFPDILPLDSHRVAlhlsvdkdpgaDYINASFAHAYreRNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDE
  ...|..  ... | . .|..|||..||||.|. ||            ||||||. . |  ...||.||.||..|.|.||||. ...  .||||..| |
efllllgipseitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelve

E-DEHFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTK----GKSTPQRICHFQVTNWSDHSVPDKP--LDLLPLLNDIQTSQQ----------
   |....|||..| ..||...|.|..|.  . .. |.. .|         ..  ..|.. ..| ||.||. |    .| ||. |.  ..          
lgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

--KSGDKAIVVQCSDGVGRSGTLCAIMSVIERVkvEHVVDVFQAVKNLRISRPG-AVETLEQYKFCYDVTLAY
   .... ..| || ||||.|||.|.. ..|..  |..||...||| ||  ||| ||..||||.|.|.. | .
llldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 283-531 4.6e-40 132.4 In-house 29-276 (439) alignment 
Range on Protein: 283-531
Range on HMM: 29-276/439.0
IFWLSPDVRVES--ASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDE
|   ||| ....  |..  . .|||. |. ..|  ||.|.  .   | . |||| . . | . . .| ||.| ..|  .|||.|..    |||||  | |
instspdyaciaslaaqeydqtknrykdvgafdhtrvtlq.eipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve

EDEhfprYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTP--QRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDKAIVVQCSDGV
       ||||..   || | |  . . .   .. | | .  .  .|   . . .|. . | |. || .   .| .|  |.....|     .||.|| ||
syk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagv

GRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTL
||.||. |.   .|..|.|  ||.   || ||  |   |..| || | |.  |
GrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_PTPN3_pd Subfamily PTPN3 285-532 2.3e-49 162.8 In-house 26-273 (280) alignment 
Range on Protein: 285-532
Range on HMM: 26-273/280.0
WLSPDVRVESASRACNASKNRFPDILPLDSHRVALHLSVDkdpgaDYINASFAH----AYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDE
   |.. .. | .. |.||||. |||| |. || |. |       |||||..      .    | .| || ||..| . ||.|| . .  .|||| .| |
rkkpglaisaarkpenlsknryrdilpydatrvklkeset.....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlve

ED-EHFPRYWPSQGA-EEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQkSGDKAIVVQCSDGV
.      .|||...   |||...|....|| .. .. | . .. | ..  ..| ..| ..|.||.|||.. |.| ... ... .. . .. .|| || |.
rGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs.gkeePvvvhCsaGi

GRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLA
||.| | ..   .  .  .. | . . |...|  |   |.| .||||  . .|.
grtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
0049772 (Phosphotyrosine protein) phosphatases II 286-535 8.7e-40 132.7 In-house 32-281 (314) alignment 
Range on Protein: 286-535
Range on HMM: 32-281/314.0
LSPDVRVESASRACNASKNRFPDILPLDsHRVALhlSVDKDPGADYINASFAHAYrerNAFILTQAPLEDTIASF----------WRMVV--DYDLGTIV
. |.  .  |.  .| .|||..|||| | .|| |  .     | ||||||. . .   ..|| ||.||| |. .|          ||||.  |... .||
vlpeltilvadlflnrdknryldilpad.nrvil..pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------LNSLDEEDehfpRYWPSQGAEEYGgikvelqeeddksffisrrfDITTKGKSTPQRICHFQVTNWSDHSVPdKPLDLL
|                     |..||.       ... .  |..                     .... ..  .... ..  ....|.|.|  . |..
msrdevladelsrLdaAlgKtpllildgng....neptaadlellk....................eelydpelferlgikylripvpDgsap.lledfd

PLLNDIQTSqqkSGDKAIVVQCSDGVGRSGTLCAIMSVIERVKvehvVDVFQAVKNLRISRP-----GAVETLEQYKFCYDVTLAYLD
 .|. |..    . .....| |..|.||.||..... .. . .    |.. .|.. .|  ||     |..|.|||| |.... | ||.
eflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 286-529 5e-13 43.3 In-house 35-274 (303) alignment 
Range on Protein: 286-529
Range on HMM: 35-274/303.0
LSPDVRVEsaSRACNASKNRFPDILPLDSHRVALHlsvdkDpgADYINASFAHAYRERNAfILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEE----
| |.|  .      |  |||| |.. ||  .| |      |  . || ||. .   ...| |||| ||  | | ||.|...  .  ...| .  |     
lppsvskn..qfvknmdknrfvdvicldhskvkls.....d..ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklg

-DEHFPRYWPSQGAEEYGgIKV-ELQEEDDKSFFISRRFDITTKGKSTPQRICHFqvTNWSDHSVPDK-PLDLLPLLNDIQTSQQKSGDKAIVVQC-SDG
 |  |||       ||   |.| |... .    .  .   ..     .   . |.   .|   |.| .    ..  . ..|.  .|  |    |     |
gdsvfprnqdflkfeers.irvgefkrvelgdgwvlkvlsvsngdyksflhvhhy..kawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsg

VGRSGTLCAIMSVIERVKVE-HVVDVFQAVKNLRISRPGAVETLEQYKFCYDV
.||.||.. . .    .. |   .|. . ..|.|  |  ||. | |. . | .
cgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 287-445 7.9e-21 68.8 In-house 82-237 (244) alignment 
Range on Protein: 287-445
Range on HMM: 82-237/244.0
SPDVRV-ESASRACNASKNRFPDILPLDSHRVALHlsvDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEHF
 ||  | . |    |. |||    ||.|  || |        |  ||||||         .|||| || ||   ||.|...  .  .|.| |..||||..
rpdpsvmkdafnpnnswknregaglpfdfnrvpls...kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeyw

PRYWPSQGAEEygGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNW-SDHSVP
|   | .  ||   | | | . |.     .  ..| .  . . | .  ||..|| || . |
pdseplewyee..ditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttp
DSPc_SM00195 288-534 1.3e-76 252.7 In-house 16-262 (263) alignment 
Range on Protein: 288-534
Range on HMM: 16-262/263.0
PdvRVESASRACNASKNRFPDILPLDSHRVALHLSVDKdPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDE-EDEHFP
   ....| .  | ||||. .||| |. || |. . .| .| |||||..   .......|.||.||..|...|||||.. .  .||||.. .| . |.  
k..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

RYWPSQ--GAEEYGGIKVELQEEDDKS-FFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSgDKAIVVQCSDGVGRSGT
||||..  | |..| |.|.|.|.. |.  .| | . .| .||...... ..|..|| ||.|||.. ..| ||. ...|...| .. |||.||.||||.||
rywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgt

LCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
...| ....... |. ||.|. ||.|| .|||.|.|||||.|.|.. |.|.
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 288-534 1.3e-76 252.7 In-house 16-262 (263) alignment 
Range on Protein: 288-534
Range on HMM: 16-262/263.0
PdvRVESASRACNASKNRFPDILPLDSHRVALHLSVDKdPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDE-EDEHFP
   ....| .  | ||||. .||| |. || |. . .| .| |||||..   .......|.||.||..|...|||||.. .  .||||.. .| . |.  
k..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

RYWPSQ--GAEEYGGIKVELQEEDDKS-FFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSgDKAIVVQCSDGVGRSGT
||||..  | |..| |.|.|.|.. |.  .| | . .| .||...... ..|..|| ||.|||.. ..| ||. ...|...| .. |||.||.||||.||
rywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgt

LCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
...| ....... |. ||.|. ||.|| .|||.|.|||||.|.|.. |.|.
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 288-534 1.3e-62 206.5 In-house 31-277 (315) alignment 
Range on Protein: 288-534
Range on HMM: 31-277/315.0
PDV-RVESASRACNASKNRFPDILPLDSHRVALHLsVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDE-HF
||. |  .|    | .|||. .|||||| || | . .|..|  ||||||. ... . .|.| .|.||. ..  |||||....  ||||.. ..|.|  . 
PdiyrqrvaretinfkknryknilPldsarvklev.iddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc

PRYWPSQGA--EEYGGIKVELQEEDDKSFFISRRFdITTKGKSTpQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSqQKSGDKAIVVQCSDGVGRSGT
 .||| . |   |.| ||||| . .  .  . |.. .| |.... ...  || |.| |. |. .   || |. ..... ... . ...| || ||||.| 
rqywPdrkadsvefGsikvellsleadtdgvarkl.vtrksees.rtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGv

LCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
...|..|....| ...||||. |||||  ||  | | |.| | ||. | .|
visidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_PTPN14_pd Subfamily PTPN14 288-535 9.2e-43 141.3 In-house 37-297 (300) alignment 
Range on Protein: 288-535
Range on HMM: 37-297/300.0
PDVRVESASRACNASKNRFPDILPLDSHRVALHLSvdKDPGADYINASFAHAY--RERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEH
 |  ...|.   ||.||||.|.|| .  || |  .  |.   .|||||  ..    ..  .| .|.||| |.  ||.|| . ..  |||| .  |.  |.
edallstaklpenaeknrfkdvlPyednrvelspt..kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

FPRYWPSQG----AEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDKA--------IVV
  .|.|...      |.|  ||  .  .| . .| . . .     .  . . |.| |.|.|| ||. . . |  |...|  ..|. ..         ..|
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlv

QCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLD
 ||.||||.| |     .|. .. ....|. .... ||  |   |.|| |||| |.| . ||.
hCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 288-531 9.7e-43 141.0 In-house 32-233 (392) alignment 
Range on Protein: 288-531
Range on HMM: 32-233/392.0
PDVR-VESASRACNASKNRFPDILPLDSHRVALHLsVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDehfp
||.    .| .  |  |||. .|||.|| || | . .|  |  ||.|||. ...   .|.| .|.|   ..  ||||| . .  ||.|.. |.| |    
pdiypqtvaqkeinlkknryknilpydsarvklev.iddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd....

rywpsqgaeeyggikvelqeeddksffisrrfdittKGKSTpQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQqKSGDKAIVVQCSDGVGRSGTLCA
                                    ||... . .. |..|.| |. || .   || .......    .  . ....|| ||||.| . .
....................................kgdda.rtvaqfhftewPdkdvpkhtssllkfikevkadf.Gqythpliihcsagvgrtgvvis

IMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTL
| ||. . |  ..||||. | |.|  ||  |.| ||| | |   |
idsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_PTPRD_pd Subfamily PTPRD 289-535 4.5e-88 291.3 In-house 37-282 (564) alignment 
Range on Protein: 289-535
Range on HMM: 37-282/564.0
DVRVESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDE-HFPR
 ...|.|.  .| .|||. .|.. |. || |. .|..|.| ||||||| ..||.|.|.| ||.||..||. ||||| ...  |||||..| |...  . .
qftweaankpaNkaKNRyanivaYdhsRVvLs.kvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQqKSGDKAIVVQCSDGVGRSGTLCAI
|||..| |.||...|.|.|| ... .. | | ...| .|  . . .|. |.| || ||... .|| |........ ... . |||.|| ||||.|| ..|
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivi

MSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLD
 ...||.| |..||..| ||.||  |.  |.| ||| |.... | .|.
damlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
subfamily_PTPN12_pd Subfamily PTPN12 289-532 2.4e-56 185.7 In-house 29-275 (290) alignment 
Range on Protein: 289-532
Range on HMM: 29-275/290.0
DVRVESASRACNASKNRFPDILPLDSHRVALHLSVDKDpGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPR
 .. |....  |  |||. |||| |  || |.   ... | |||||.| .   .. ..| .|.|| .|.  ||||. ....  .||.  . | .  .  |
vysteagekeenvkknrykDilPydksrvelskieeee.gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPSQGAEE--YGGIKVELQEEDDKS-FFISRRFDITTKgkSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQkSGDKAIVVQCSDGVGRSGTL
|||..| ||  .| ..|.|.||.  .  |. | . ....  .. ...  |. |.| || || .. .|| |...... |. | |. .|| || |||| ||.
YWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGti

CAIMSVIERVKVEHV---VDVFQAVKNLRISRPGAVETLEQYKFCYDVTLA
.||  | | .| |..   .|||. | .||  |. .| | |||.. |   . 
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_PTPN9_pd Subfamily PTPN9 289-533 6.9e-54 177.9 In-house 31-289 (297) alignment 
Range on Protein: 289-533
Range on HMM: 31-289/297.0
DVRVESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDE-HFPR
  ... .   .| .|||. |.| .|. || |  .||.|. .|||||.|   |....||| || ||. |.  ||||| . .  .|||   . |.      .
eGtflasklranleknrytdvlcydetrvvla.kvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgq

YWP--SQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKS------------GDKAIVVQ
|||  .. ..|.| ..|.  | . .. .  | . |.   ..  ... |||.. | |. ||.   .|| .|. ..  | ..             .  ||| 
yWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvh

CSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
|| |.||.||....   ..|.. . .|||...|| ||  |  .. | |||.|||   | |
csaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_PTPN1_pd Subfamily PTPN1 289-528 3.1e-45 149.1 In-house 21-265 (290) alignment 
Range on Protein: 289-528
Range on HMM: 21-265/290.0
DVRVESASRACNASKNRFPDILPLDSHRVALHLSVDkdpgaDYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPR
|.....| .  | ..||. |. | |  |. |. .       ||||||. .. . .  .|||| || .|.. ||.|| . .  ..|||| . |..     .
dfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaq

YWPSQGA---E--EYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDK-AIVVQCSDGVGRS
|||..        |   .||.| .|..||... | .... .     . | ||  | |.| .||. |  .| .| ... |   | |.   |. || |.|||
ywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GTLCAIMSVIERV---KVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYD
||.| . ... ..   .    ||. . . .||  | | . | .| .| | 
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl
subfamily_egg_pd Subfamily egg 289-533 9e-26 85.2 In-house 29-269 (307) alignment 
Range on Protein: 289-533
Range on HMM: 29-269/307.0
DVRVESASRACNASKNRFPDILPLDSHRVALHLSVDKDPGaDYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEdEHFPRY
.. .. |  . |  | | . .   || ||.|.|   .  . |.| |   .     | |||.|||| .|   |||||   .   ||||.|  |  |. . |
eislttaasdnnlekarskrvhckdssrvklelrrGqyld.dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyy

WPSQGAEE----YGGIKVELQEEDDKSFFISR--RFDItTKGKSTPQRICHFQvTNWSDHSVPDKPLDLLPLLNDIQtsqqksgdKAIVVQCSDGVGRSG
||   ..      |....|  . |.|.  . |  .. .   |.   . . |.|  ..   |    || .| .| ..         | .|||. .|| ...
wpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwq.gdvnnssdvysplrvlrklrnls........kpvvvqdilGvskaa

TLCAI----MSVIERvKVeHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
|| ||    .|..    .     | .||. ||  |. .||.  .| | | . | .
tlvaieiallsllrG.pi.tkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_PTPRA_pd Subfamily PTPRA 291-533 7.9e-70 230.3 In-house 49-294 (330) alignment 
Range on Protein: 291-533
Range on HMM: 49-294/330.0
RVESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYW
 .| ||.  |  |||...||| |  || |   ..  . .||||||| . |.|.. || .| |.|.|.  ||||. ...  |||||  |.| . |   .||
tlelaskeenkeknrvvnilPydfsrvils.vkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PSQGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKST----PQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDkAIVVQCSDGVGRSGTLC
|..|.  || |.||...|     .  | | .. ....|    .. .  |  | | |  || .|  .| ||. ... .|.|.. .||| || ||||.||..
PdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfi

AIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
.. .|.|||| |..||||..||.||  ||  | |.|||.|.| | | |
vldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 292-531 3.9e-59 195.1 In-house 41-276 (315) alignment 
Range on Protein: 292-531
Range on HMM: 41-276/315.0
VESASRACNASKNRFPDILPLDSHRVALHLsVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEHFPR-YWP
.. | .  |  |||. .|.. |  || | | ...||..||.||.|   |  .. .| .|.|.  ..  |||.| ..|.|.||||..| |....    |||
ldvakkienkqknryiniiaydksrvqlpl.lendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

SQgAEEYGGIKVELQEEDDKSFFISRRFDITTkgKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGdKAIVVQCSDGVGRSGTLCAIMSV
 .    || | | ...|. .. .  | . ..   ..  . .  ...| | |  ||   . |. |   ..  ...|   |||| ||.||||.||.... .|
dk.kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldav

IERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTL
......|...||.......|  | ..|...|||.| ||. |
ldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_PTPRN_pd Subfamily PTPRN 292-528 1.9e-39 130.2 In-house 48-286 (297) alignment 
Range on Protein: 292-528
Range on HMM: 48-286/297.0
VESASRACNASKNRFPDILPLDSHRVALHLSVDKDpGADYINASFAHAYRERN-AFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEH-FPRYW
 | |..  |..|||  ..|| |  || |. . ...   ||||||.      |. |.| ||.|| .|.|.||.|| .     ||.| .|.||. .   |||
kevakaeknvkknrskavlpydhsrvklkeeasae.ksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PSQGAEEYGGIKVELQEEDDK-SFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKsGDKAIVVQCSDGVGRSGTLCAIM
| .|.| |.  .|.|  |      .. | | .    .|  . .  |    | ...|| ..  || .   .. | .     .||| ||||.||.|. ..| 
pdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilid

SVIERV-KVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYD
 |..|. |  . .|.  ... ||  ||| |.| .|..|.. 
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 292-531 5.8e-31 102.2 In-house 46-280 (290) alignment 
Range on Protein: 292-531
Range on HMM: 46-280/290.0
VESASRACNA--SKNRFPDILPLDSHRVALHlsvDKDPGaDYINASFAHAYreRNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRY
.|      |.   |||. |.   |  || |.   |  .| ||. | . .    .  ||||| .|.||.  .||||.. .  .||||  | |.   .  .|
lerkifdkntefkknrykdvvcndktrvilk...dGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPSQGAE--EYGGIKVELQEEDDKSFFISR-RFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSqqkSGdkAIVVQCSDGVGRSGTLC
.| .  |   .| | |   |||||   | .  . .  | .    .. |...  | |.||.   | || .|  ...    ||   .|| || |.||.||. 
ypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka...sG..pvvvhcsaGiGrtGtfv

AIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTL
||   .. .   . .|. . |. || || ..|.   ||    .. |
aievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 292-350 5.1e-09 30.2 In-house 40-94 (95) alignment 
Range on Protein: 292-350
Range on HMM: 40-94/95.0
VESASRACNASKNRFPDILPLDSHRVALHLSVDkdpgADYINASFAHAYRERNAFILTQ
    |  .|  |||| .|.| |. ||.|    |    .||||| |   |  .|..| .|
ytvgsseanipknrflnifpydatrvvlttkrd....sdyinacfvdgyarkncyiaaq
subfamily_PTPRK_pd Subfamily PTPRK 293-531 1.8e-68 225.7 In-house 36-274 (314) alignment 
Range on Protein: 293-531
Range on HMM: 36-274/314.0
ESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWPS
..| .  | .|||. |||. | .|| |. ..| || .|||||..  .|.  .||| || ||..|.. |||.| |..  .||||. | |.   .  .||| 
daakkdenreknrsgdilaydrsrvfli.tidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

QGAEeYGGIKVELQEEDDKSFFISRRFDITT--KGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKsGDKAIVVQCSDGVGRSGTLCAIMS
..   || ||||| | . .. ...| | ..   .|..  . . .|| ..|.|| || .   || |.  ...||.. ..  ||| || | ||.|| .|| .
dtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidi

VIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTL
|.. .. |.|||||.|||.|| ...  ||| |||||.||| |
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvil
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 293-532 2.6e-58 192.7 In-house 41-286 (325) alignment 
Range on Protein: 293-532
Range on HMM: 41-286/325.0
ESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEHFPRYWPSQ
. | .  | .||||.....||  || |  . ..|| .||||||. . ..... |. .|||| .||  .||.|.|.    .|.|| ||.....   ||| .
kvamkpenkaknrfknvvaldksrvvle.tkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpke

--GAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQ-----KSGDKAIVVQCSDGVGRSGTLC
   . ..||..|.|.  .. | .. |..|.    |   . .  ||.  | |  |. .|  |...|. ... ..       .   |.| ||.||||.|.. 
mgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfi

AIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLA
.. |....|  |  ||.|. ||.||  ||  ||| .|| ..|.    
slysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 293-527 1.8e-36 120.5 In-house 1-234 (239) alignment 
Range on Protein: 293-527
Range on HMM: 1-234/239.0
ESASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRE-RNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWP
|.| .  | .|||. .|.  |  || |   . .|| .||||||. . |    .|.| ||  .| .   ||||. .     ||||  | |   ..  .|||
eaakkrvnkaknryanivtydhsrvvle.klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp

SQgAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIqTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSV
   . .|  ..| |.. .  . .| | | ..  |..  . . ....| | |. ||.    .| |   | | .   | .  |..|| ||||.|..  | ..
ds.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihcsagvgrtgaflvidam

IERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCY
. . | .. ||.|. || .|  ||  |.| ||| | .
lrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 293-450 4.1e-21 70.1 In-house 26-185 (297) alignment 
Range on Protein: 293-450
Range on HMM: 26-185/297.0
ESASRACNASKNRFPDILPLDSHRVALHLSVdkdPGADYINASFAHAYRERN--AFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYW
 || |     |||. |||  |. || |  ..   .. ||||| .     | .   .||.| ||..|.  ||..|.. |...|||.  | |.  .    ||
ssakrnsslrknryrdilatddtrvkllrvi...terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PSQ--GAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLD
||   .  . | . ||   .    |      ...   .|  . . | |  .| || ||    |
psvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdled
0042113 (Phosphotyrosine protein) phosphatases II 294-534 3.9e-69 228.1 In-house 3-243 (245) alignment 
Range on Protein: 294-534
Range on HMM: 3-243/245.0
SASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWPSQ
.|.. .| .|||..||||.|. || |  ... |.. ||||||. . ||  . ||.||.||..|.. ||||. .... |||||....| . . ...|||..
vallpenkdknrysdilpydhtrvkls.pdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSVIE
.  .||...|.| .|. .. .. | . .| .|.. .. ..|.. ..| ||.||| . .|| .|. ... ....... ..| ||.||||.||..|.  ..|
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
... |. |....||| ||  |||||.|..||.|.|.. | .|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 294-533 4.4e-69 228.1 In-house 5-245 (249) alignment 
Range on Protein: 294-533
Range on HMM: 5-245/249.0
SASRACNASKNRFPDILPLDSHRVALHLsVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWPSQ
 |.. .| .|||.|||||.|..|| |.  ... .. ||||||. . |.  ..||.||.||..|...||||. ... ..||||.||.|   |.. .|||..
vallpenkdknrypdilpydhsrvklsi.lpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKS-GDKAIVVQCSDGVGRSGTLCAIMSVI
|  |||...|.| ... |. .. | . .| ...... .. |.|.|.| ||.||. . ||| ... ... ...   .. ..| ||.||||.||..|.  ..
gsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

ERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
|... |. ||...||| ||  |||||...|||.|.|.. | .
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 294-533 2.8e-62 205.7 In-house 4-241 (243) alignment 
Range on Protein: 294-533
Range on HMM: 4-241/243.0
SASRACNASKNRFPDILPLDSHRVALhlsvdkdPGADYINASFAHAYrERnaFILTQAPLEDTIAS----FWRMVVDYDLGTIVMLNSLD-EEDEHFPRY
 |.. .| ||||..||||.|  || |       .| |||||..   . .|  .|.||.||..|...    ||||. ... ..||||..|.  . |  ..|
iallpenlsknrysdilpydhsrvkl.......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPsqGAEEYGGIKVELQEEDDKSFFISRRFDITTKG-KSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQK-------SGDKAIVVQCSDGVGR
||  | ..||...|.| .|  .. .. | . .. .. .  .. ..|.. ..| ||.||| | ||| .|..... ...       .... ..| || ||||
wp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

SGTLCAIMSVIERVkveHvVDVFQAVKNLRISRPG-AVETLEQYKFCYDVTLAY
.|||.|.  .....   . ||...||| ||  ||| ||.|..||.|.|.. | .
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_CG7180_pd Subfamily CG7180 294-533 2.5e-58 192.1 In-house 36-289 (296) alignment 
Range on Protein: 294-533
Range on HMM: 36-289/296.0
SASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEHFPRYWPSQG
 . |. |  ||| ....| |  || |. ..| .   |||||..  ..   ...| |.|| ..|. .|||.| | .  ..|.|    .  . .| ||| ..
gglrkenreknrdvkvvPyDynRvvLe.kldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks

AEEYGGIKVELQEEDDKSFFISRRFDITTK---------GKSTPQRI-CHFQVTNWSD-HSVPDKPLDLLPLLNDIQTSQQKS----GDKAIVVQCSDGV
 |.|| | ||. ||.  . . .| | .| |         . ....|| ..||.| |   ..||     |. |.. ... ..|       . .|| .|||.
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
.|||  .||   .| |. |. ||||.||| ||.|||. ||. |.||..||| | .
sRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 294-530 1.8e-45 150.0 In-house 26-255 (267) alignment 
Range on Protein: 294-530
Range on HMM: 26-255/267.0
SASR-ACNASKNRFPDILPLDSHRVALHLSVDKdpgadYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDehFPRYWPSQ
| |    |. .||. | || |  || |  . .      |||||. ..|. .||||.|| ||. ||. |. .. |... .||.|    ...   ...|| .
sqsiaeknqernrlddnlpyddtrvilrtkeee.....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..irlfwPPk

--GAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTpQRICHFQVTNWSDhSVPDKPLdLLPLLNDIQTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSV
   |..|  . ||   | ..  .    ...  | .|. . .  .   .|    . .||  | ||.  .   | . |.. .||.||||||||||.  | | 
mgqakkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwni.ntnnkpy.lkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsq

IERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVT
.||.| | |.|.|. ....|  |.| |.|.|.| ..... 
leraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_eak_pd Subfamily eak 294-447 1.8e-17 57.8 In-house 46-197 (332) alignment 
Range on Protein: 294-447
Range on HMM: 46-197/332.0
SASRACNASKNrFPDILPLDSHRVALHLSVDKDPGadYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVML-NSLDEEDEHFPRYWPSQ
 ..|  .  .|   .|.| | . | |  |     |  ||||| |      . .||| .. || .  ||.||..    .||.| . .... |.. .|.| .
etarleavnrn.vvkivpydrylvrltssqlnrlG..yinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

GAE--EYGGIKVELQEEDDKSFFISRRFDItTKGKSTpQRICHFQVTNWSDHSVPDK
. |  ..| ..|| .|   .. .  | . . .||  |  |. |..|  |.. ..|  
treelkfGildverkefvkrniletrllel.skGnet.hrvlhykvfGwtettlpky
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 295-536 2.2e-86 284.1 In-house 4-244 (250) alignment 
Range on Protein: 295-536
Range on HMM: 4-244/250.0
ASRACNASKNRFPDILPLDSHRVALHLSVdKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEHFPRYWPSQGA
| .  |  |||. ||..||| || |. .   |  .|||||||.|.|.||.||| ||.||..||  |||||.... ||||||..| |... ...||| ..|
akkpqnkeknryadiialdssrvvLekek.gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka

EEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSVIERV
|.||...|.| ... .. ...|.. .. . |.  . . ... ..| | .||..    | ||...|.|||..|.. ..|||| ||||||. .|| .|.||.
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

KVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLDS
| |.|||||. .| ||. ||.|||.|||| |.| . | .|||
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 295-535 4.4e-61 201.6 In-house 46-285 (297) alignment 
Range on Protein: 295-535
Range on HMM: 46-285/297.0
ASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRErnAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEHFPRYWPSQGA
| .  | .|.|. .||| || || |. .|..|| .||.|||| .....   .| || | ..|.| ||.||.|..  |||||| ..|.|..  |||. .| 
aekkvnfeksRYkniLPydssRvkLa.ivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgv

EEYGGIKVELQEEDDKSFFISRRFDITtKGK-STPQRICHFQVTNWSDHSVPD--KPLDLLPLLNDIQTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSVI
 ..| . |.|.  .... || | ...| |||  . . .  .| ..| |..|.   .   || |..... . ..  .  ..| |. |||| | |..| ||.
ttfGdvsvvllsvsereGfikrelevt.kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

ERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYLD
 ..| |. ||.|. || || .||  | | ||||| | . | .| 
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 295-527 3.6e-36 119.5 In-house 2-233 (239) alignment 
Range on Protein: 295-527
Range on HMM: 2-233/239.0
ASRACNASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRE-RNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWPSQ
| .  | .|||. .|.  |  || |   . .|| .||||||. . |    .|.| ||  .| .   ||||. .     ||||  | |   ..  .|||  
akkrvnkaknryanivtydhsrvvle.klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

gAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIqTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSVIE
 . .|  ..| |.. .  . .| | | ..  |..  . . ....| | |. ||.    .| |   | | .   | .  |..|| ||||.|..  | ... 
.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.tkdslpgarpwvihcsagvgrtgaflvidamlr

RVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCY
. | .. ||.|. || .|  ||  |.| ||| | .
qakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 296-534 5.4e-58 191.3 In-house 39-276 (515) alignment 
Range on Protein: 296-534
Range on HMM: 39-276/515.0
SRACNASKNRFPDILPLDSHRVALHLsVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEH-FPRYWPSQGA
    | .|||. .|||.|| || | . .. .|  ||.|||. ...   .|.| .|.|.. ..  |||.|....  ||.|.. | |.|     .||| . .
qeeinfkknryknilPydsvrvklev.indnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

E--EYGGIKVELQEEDDKSFFISRRFDITTKGKstPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGdKAIVVQCSDGVGRSGTLCAIMSVIE
.  ..| |||||   .  .  | |.. ..   .   . .  |. |.| |. || .   || |. ........    .... || |||| | ...|.||. 
dsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvva

RVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
..|  ..||||. |.|.|  ||  | | ||| | |.. | .|
hakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_ptpA1_pd Subfamily ptpA1 296-498 3.8e-30 99.9 In-house 43-258 (418) alignment 
Range on Protein: 296-498
Range on HMM: 43-258/418.0
SRACNASKNRFPDILPLDSHRVALHLSVDKDpGADYINASFAHAYRErNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWPSQ--
 .  |.||||. .|||..  || |.   ||. |.||||| .       . || || || .||| ||||| .     ||||.   |.   .  |||| |  
dkkhntsknrytnilpvnhtrvqlkkiqdke.gsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

---------GAEEYGGIKVELQE--EDDKSFFISRRFDITTKGKStpQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQK---SGDK--AIVVQCSD
         | | .|   ||| |  .| .   |.|   .| .|..  . | ..|   | || .||.   .  ||  |   |..   | |.   |.|.|| 
geqfsiygngnevfgtysvelveviqdpereiitrnirltfeget..rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsa

GVGRSGTLCAImsVIERVKVEH
||||.||.|.   ||   |..|
gvgrtgtfcta..vimmkkldh
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 296-532 5e-29 95.8 In-house 33-267 (281) alignment 
Range on Protein: 296-532
Range on HMM: 33-267/281.0
SRACNASKNRFPDILPLDSHRVALHLSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDE-EDEHFPRYWPSQGA
 .  |  |||. .|  ||  || |.. . .   .||| | . ..   .  .|||| | ..| | ||||. . .  .||||  . | . |.   |.| .  
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

--EEYGGIKVELQEEDDKSFFISRRFDITTKGKStpQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSqqkSgdKAIVVQCSDGVGRSGTLCAIMSVIE
   ..  . |. ..   .  ... |.... .|..  . | |.   .| |  ||.    .| .|  |..    |     |..|| |||||||| |.   ..
cclqfdklsvsyedstvnkslvttrlnlsyeget..rlithwlwkewpdwqvpessevmlkilrkirar...s..tppvihcsagvgrsgtlmaveialq

RVKVEH-VVDVFQAVKNLRIS-RPGAVETLEQYKFCYDVTLA
 ..    . |. | |  ||.. |  .|.||.|| . . | | 
sihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 296-534 2e-26 87.3 In-house 51-289 (305) alignment 
Range on Protein: 296-534
Range on HMM: 51-289/305.0
SRACNASKNRFPDILPLDSHRValhlSVDKDPGADYINASFAHAY-RERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNS-LDEEDEHFPRYWPSQG
|   . .|||. |.   |   |     .|| . .||| | .  .     . || .| ||..||  || ||..  .  ||||   ..    .  .|||   
sadiaitknryqdvpcqdqsav....kldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

AEE---YGGIKVELQEeDDKSFFISRR-----FDITTKGKSTpQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQksgdkAIVVQCSDGVGRSGTLC
 |     .|| ||      | .          ...|  |. .   . |.| |.| |  ||   |  | ||  |. |.       |||.|| |.||.||. 
geklelksgivvenvs.gskpmerdaeiqitllnltysgdqk.msvrhlqwtewpdrgvppckltslellsairgskv.....pivvhcsagigrtgtiv

AIMSVIERVKVEH-VVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
||  ..|..  .. .  . . || ||  |  ....  || | . | | |.
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 297-534 3.2e-55 181.9 In-house 37-293 (301) alignment 
Range on Protein: 297-534
Range on HMM: 37-293/301.0
RACNASKNRFPDILPLDSHRVALHLSVDKD-PGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWPSQ--
.  |.  ||| .| ..| .|. |.   . |    .|||||. ..|.|...|| .|.|.. |.. |||.....   .|||.  |.|.  ..  .|||.   
seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea

GAEEYGGIKVELQEEDDKSFFISRRFD-----------------ITTKGksTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDKAIVVQCS
  ||.| ..|.|..|     |. |..                  ....   ... .  .|||.| .. |   |   |  ..|.   ||| |   .|| ||
eseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCS

DGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
|.|.|||. |..   .| .| | |||||| .| .| |.|||| ||||| . |||   ||
dtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 297-534 2.6e-49 162.6 In-house 17-264 (270) alignment 
Range on Protein: 297-534
Range on HMM: 17-264/270.0
RACNASKNRFPDILPLDSHRVALhLSVDKDPGADYINASFAH-AYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWPSQGA
 | ..  ||. ||||    || |  ....|. . |||| . . .  |....| ...||. |. |||||...    .|||.  | |.  ..  ||||..  
aargkklnRyadiLPsPatRvrl.eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

E----EYGGIKVELQEEDDKSFFISRRFDITTKGKStpQRICHFQVTNWSDHSVPDKPL------DLLPLLNDIQTSQQKSGD-KAIVVQCSDGVGRSGT
|    |.| |||  ..|  ....| .|  ...||..  .|..||. ..| ||.|| ..       .|| .|.... |...  . . ..| ||.||||.||
ekvkledgkikvlalseekeegyiltrlrleekgee..rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

LCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
| |.  ... .. .. ||| . ...||  |.  |.. |||.| | . . | 
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 298-530 8.3e-58 191.1 In-house 23-251 (284) alignment 
Range on Protein: 298-530
Range on HMM: 23-251/284.0
ACNASKNRFPDILPLDSHRVALHLsVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNsldeeDEHFPRYWPSQGAEEY
  |  |||. .||. |  .| |.  ..   ..|||||||   |. .. .| || ||..|.| ||||. .|.  |||.|      ...  .||| .. ...
dqnkdknrighilafdknvvkler.liGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivike

GGIKVELQEEDDKSFFISRRFDITTKGKSTPQR-ICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQ-KSGDKAIVVQCSDGVGRSGTLCAIMSVIERVK
.  ||...  .. . .. | .... .|| . .| |  |    | |. ||| | ||. |.. ..  .. . . . ||| || ||||.|.  ..  ...|.|
erfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmk

VEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVT
 |. |||.. |..||  |.  |. | ||||.|   
eekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 298-534 4.7e-54 178.3 In-house 26-268 (274) alignment 
Range on Protein: 298-534
Range on HMM: 26-268/274.0
ACNASKNRFPDILPLDSHRVALHLSVDKDPGADYINASFAHAYRE-RNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDE-HFPRYWPSQG--
. ...|||. .||| .  || |. .  .|. ..|||| . . |.|  .|.. || ||  |.| ||||.   .   ||||  | |..|    .|.| .   
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--AEEYGGIKVELQEEDDKSFFISRRFDITTKGKstPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDK--AIVVQCSDGVGRSGTLCAIMS
  .|.||..... ..  ..  .  |.. .    .  .... |.  |.| || .||..  || |......|....  |  ..|| || |.|| |   ||  
eiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

VIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
 . ... |.||||.. | |||. | | |.| |||.. . .   ||
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 298-533 4.8e-22 73.2 In-house 33-269 (285) alignment 
Range on Protein: 298-533
Range on HMM: 33-269/285.0
ACNASKNRFPDILPLDSHRVALhlsvdKDPGADYINASFAHA-YRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWPSQGAE
 .|   ||. |.  ..  || |     |.   ||| ||. .   ......| || || .|.. ||.|. .  .  ..|| .| |   |.   |.| .  |
eanpdlnryadvrcieetrvvl.....knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

--EYGGIKVELQEEDDKSF----FISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKsgDKAIVVQCSDGVGRSGTLCAIMS
  ..|  .. | |  ...     . .     |    | |  . | ||  | |.  |.    .. | . ..  . |  .| |.|.|| ||||. |.  |  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidy

VIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
   |.  .  ..... |...|  |  ||..  |. | | | . |
atirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 298-406 1.4e-15 51.9 In-house 45-164 (350) alignment 
Range on Protein: 298-406
Range on HMM: 45-164/350.0
ACNASKNRFPDILPLDSHRVALHLSVDK-------DPGADYINASFAHAY----RERNAF--ILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-E
    .|||. .||| .  || |. |.           . |||||.. .      .    |  | |||||  |.  |.....  .   |..|.|..| . |
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnle

HFPRYWPSQGaeeYGGIKVELQE
 . |||.  .   | .|.| |..
kcyrYWqegs...ydditvklas
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 299-534 1.6e-30 101.1 In-house 42-271 (288) alignment 
Range on Protein: 299-534
Range on HMM: 42-271/288.0
CNASKNRFPDILPLDSHRVALHlsvdkDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWPSQGAEEY
 |....|. ..   |  || |.     |    ||.|    . . .. .| .||||. ||  .|.|... |.  ||||. | |   |.   |.||.  |. 
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

GgIKVELQEEDDKSFFISRRFDIT----TKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIqtsqqKSGDKAIVVQCSDGVGRSGTLCAIMSVIER
  |.   .   .|   | .   ..    .|   ... . .  . .| |..||.. |  | ||. .     || .| |||..| ||||.|||  |. ..| 
r.igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililiales

VKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
....  . . . ...|| .|  |..|  || . . . | .|
lrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 299-374 5.6e-09 30.0 In-house 36-115 (347) alignment 
Range on Protein: 299-374
Range on HMM: 36-115/347.0
CNASKNRFPDILPLDSHRVALHLSV----DKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVM
 . ||||  |    |. || |          |.   |||||  .    .. .|||| || ||.  ||.||    .  .| 
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
Y_phosphatase Protein-tyrosine phosphatase 300-531 6.7e-73 240.3 Pfam-A 1-234 (235) alignment 
Range on Protein: 300-531
Range on HMM: 1-234/235.0
NASKNRFPDILPLDSHRVALhlsvDKDPG-ADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWP--SQGAE
| .|||..|||| |. || |    ....|  |||||.. . |.| ..||.||.||..||..|||||....  .||||.||.|. .|....|||  ... .
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGGIKVELQ--EEDDKSFFISRRFDITTKGKS-TPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQqKSGDKAIVVQCSDGVGRSGTLCAIMSVIE
.|| |||||.  |..|.. .. | .... |...  .... ....||| ||.||..| .|| |......|. .. .. .||.||.||||.||..|.. ..|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

RVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTL
... |. |||.|.||.|| .|||.|..||||.|.|.. |
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 300-531 6.7e-73 240.3 In-house 1-234 (235) alignment 
Range on Protein: 300-531
Range on HMM: 1-234/235.0
NASKNRFPDILPLDSHRVALhlsvDKDPG-ADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWP--SQGAE
| .|||..|||| |. || |    ....|  |||||.. . |.| ..||.||.||..||..|||||....  .||||.||.|. .|....|||  ... .
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGGIKVELQ--EEDDKSFFISRRFDITTKGKS-TPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQqKSGDKAIVVQCSDGVGRSGTLCAIMSVIE
.|| |||||.  |..|.. .. | .... |...  .... ....||| ||.||..| .|| |......|. .. .. .||.||.||||.||..|.. ..|
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

RVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTL
... |. |||.|.||.|| .|||.|..||||.|.|.. |
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 300-533 5.1e-42 138.9 In-house 1-170 (182) alignment 
Range on Protein: 300-533
Range on HMM: 1-170/182.0
NASKNRFPDILPLDSHRvalhlsvdkdpGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNsldeedehFPRYWPsqgaeeygg
| .|||..|||| |  |           . |||||..   ..  . ||.||.|| .|.|.|.||. ... .|||.|.         ..|||         
nldknrysdilpydhsr...........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp.........

ikvelqeeddkS-FfisrrfdittkgkstPQRICHFQVTNWSDHSVPDkPLDLLPLLNDIQTsqqksGDKAIVVQCSDGVGRSGTLCAIMSVIERvkveH
           . .               .. ..... ..| ||.||| . .|| ......       .....| || ||||.|||.|.  ....    .
...........ell...............erlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g

vVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
 |....||| .|  |||.|.|..|| |.... | .
.vsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 300-529 5.3e-33 109.2 In-house 3-234 (237) alignment 
Range on Protein: 300-529
Range on HMM: 3-234/237.0
NASKNRFPDILPLDSHRVALHLSVDKdpgADYINASFAHAYRE-RNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDE-HFPRYWPSQG-AEE
|  |||. .|   |  || |. .  .   .|||||.. . .    . .| .| ||| .   ||.|| .     ||||  | | .| .  .||||    . 
nkiknrygnivaydhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICH-FQVTNWSDHSVPDKPLDLLPLLNDI-QTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSVIERV
|| . | |. ... | .  | . ......    |. | .| | | |. ||..   || .  .| . |.  |     .. || ||||.| .  | ... . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDV
| ..|||... |...   ||  ..| .|| | ...
kekkvvdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 300-533 2.4e-26 87.0 In-house 52-289 (310) alignment 
Range on Protein: 300-533
Range on HMM: 52-289/310.0
NASKNRFPDILPLDSHRVALhlSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEhfPR---YWPSQGA-E
.  |||. |.. ||. || |   .||    ||| | . ..   |..|| .| ||. ||  ||||. .    .|..|    ||    |.   |||| |  |
ymhknrysdvvcldtsrvkl..kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegr..pkcvgywpslgvte

EYGGIKVELQEEDDKSFFISRrFDITTKGKS----------TPQRICHFQVTNWSDHSVPDKPLDLLPllnDIQTSQQKSGdkAIVVQCSDGVGRSGTLC
 || |.|    |  . | |   . .|                  |.   .  || |  |||.    .|   .   .| . |    ||.|| |..| ....
tygcirvtnlsesseefeicn.lavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp...qrllaqvrhg..pcvvhcsagkdrlyvvv

AIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
|.   |....  . ||. . . .|. ||   ..|  || .   | ...
alklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 300-534 4.4e-23 76.2 In-house 51-285 (302) alignment 
Range on Protein: 300-534
Range on HMM: 51-285/302.0
NASKNRFPDILPLDSHRVALHLSVDkdpgaDYINASFAHAYRERNAFILTQAPLEDTI---ASFWRMVVDYDLGTIVMLNSLDEEDEHFPRYWP--SQGA
| .||. .|.  |||..| |. . |     .|.|||  .    ..  ||.| |  |.    ..||||| .    ..|.|   .| .. .  ..|  |.  
nlkknqsedvpildsnlvkleaepd.....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdy

EEYGGIKV-----ELQEEDDKSFFIsrrfDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIqTSQQKSGDKAIVVQCSDGVGRSGTLCAIMS
.||| . |     | .||. . . |    ..  .| |    .    .||| ...||.|  .|     ..   .. ..|. .|.    |.|| |.. . . 
keygkmfvNnrkVekaeeektryvi....EvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.fakkikadentvivSknGaGRagafltlav

VIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
..|... .. . . . ||..|  || ||..|.|| . | ..| |.
aveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_CG42327_pd Subfamily CG42327 300-461 3.3e-21 70.3 In-house 28-193 (319) alignment 
Range on Protein: 300-461
Range on HMM: 28-193/319.0
NASKNRFPDILPLDSHRVALHlSVDKDPGADYINASFAHAYRE-RNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWPSQ----G
   |.|. ...||   || |. .. .|.   |..||.   |.. .| .| .|..|||. ..|||.| .    .|| | .| |   .  ..|.|..    .
skdksrvinvvPlPetrvvlq.rigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

AEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVtNWSDHSVPDKPLDLLPLLNDIQTS
 . || |.| |.. . |  ..   . .    |.  . . |.   .| .  || ..  |. .| ....|
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 300-383 3.6e-10 33.8 In-house 34-115 (332) alignment 
Range on Protein: 300-383
Range on HMM: 34-115/332.0
NASKNRFPDILPLDSHRVALHLSVDKDpgaDYINASFAHAYRERNAFILTQAPLEDT-IASFWRMVVDYDLGTIVMLNSLDEEDE
|   || | .  .|  || |     ||   |. |||.   | ...|.|..|||..|     ||||| .     |...  .||...
nmdmnriphlycfdhsrvelapqdgkd...dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 300-408 3e-08 27.4 In-house 48-169 (349) alignment 
Range on Protein: 300-408
Range on HMM: 48-169/349.0
NASKNRFPDILPLDSHRVALHLSVDKDPG-------------ADYINASFAHAYR--ERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEED-E
  .|||. |||| .  || |. |.    .              ||||| . .  |    . .| |||||  |.  |.....   .  .. ||. .|.. |
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

HFPRYWPSQgaeEYGGIKVELQEED
 . .||      .| .|.| ||.  
kcdiywqel...sysnitvklqnss
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 302-523 1.5e-26 87.8 In-house 52-270 (301) alignment 
Range on Protein: 302-523
Range on HMM: 52-270/301.0
SKNRFPDIlPLDSHrVALHLSVDkdPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLD-EEDEHFPRYWPSQGAEEYGG-
 |.|.| . | . .  |... ||       | | .  .  . . || ||.||..|   || |.| ||. .||||     .. |.   | |.. .|.    
dkhryptv.PckPs.tavevivd..GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

---IKVELQEEDDKSFFISRRFDIT-TKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSqqksgDKAIVVQCSDGVGRSGTLCAIMSVIERVK
   ||.. .|   .   . |..... . || ... . |.| ..|.|. ||    .|  |.. .. |     .| |||.||.|.||| .. .   .  .|.
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsaGiGrsvafigteylareve

VEHVVDVFQAVKNLRISRPGAVETLEQY
 .  ... .|.|.||  |  .| | .| 
adptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 303-534 1.2e-19 65.1 In-house 46-276 (312) alignment 
Range on Protein: 303-534
Range on HMM: 46-276/312.0
KNRFPDILPLDSHRVALhlSVDKDpgaDYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWPSQ-G------A
 ||.|.|   |  | .|  . |..    || | | .     . |. ||.|||.|.. ||....     .|..| .. |.  |.  .|     |       
lnrypniqcwdrgrftl..agden...fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

EEYGGIKVELQE-EDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIqtsqqKSGDKAIVVQCSDGVGRSGTLCAIMSVIER
  |     |..     |     | . .  |      .. |.| . | || .||     | ||  .     |   | .. .|| ||||.|||. | |.|  
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaa

VKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
..     .| ..   ||  |  .|... || ..  . | .|
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 318-443 9.1e-17 55.6 In-house 2-126 (130) alignment 
Range on Protein: 318-443
Range on HMM: 2-126/130.0
ALHLSVDKDPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEHFPRYWPSQGAEEygGIKVELQEEDDKSFFISRR
||.  |.. .| .||||||       . ..|||.|| ||   ||.|...  .  .|.| |..||||..|   | .  ||   | | | . |.  .  .  
alefevsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyee..diivtltdrdefknikasn

FDITTKGKSTPQRICHFQVTNWS-DHS
..|  . . . | .  ||..||  | .
leiesdlneshqaltmfqisnwpsdgt
0044763 (Phosphotyrosine protein) phosphatases II 324-529 1.8e-25 85.0 In-house 13-166 (178) alignment 
Range on Protein: 324-529
Range on HMM: 13-166/178.0
DKDPGADYINASFAHAYrernaFILTQAPLedtiASFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWPSQGAeeyggikvelqeeddksffisrrfditt
   ...||||||.   .     ..|...|     |...... ......||.|.. .|   .. ..|||..                              
eglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag............................

kgkstpqriCHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGdKAIVVQCSDGVGRSGTLCAIMSVIERvkveHVvDVFQAVKNLRISRPgAVETLEQ
         .... ....||.||| .  .| ... |.. ....| ....| || ||||||||.|.  ....    .. ....|.. .|  || .|.. .|
.........iqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgq

YKFCYDV
....|..
lrqLyef
0046846 (Phosphotyrosine protein) phosphatases II 325-534 6.7e-38 125.5 In-house 8-173 (176) alignment 
Range on Protein: 325-534
Range on HMM: 8-173/176.0
KDPGADYINASFAHAYRernaFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDEH-FPRYWPSqgAEEYGGikvelqeeddksffisrrfdittk
 |.. |||||...  .|    .| ||.||..|.|.|..|. ... ...|.|... | . . .|.|||    |..|                         
ldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi........................

gkstpqricHFQVTNWSDHSVPDKpLDLLPLLNDIQTSQQKSgdKAIVVQCSDGVGRSGTLCAIMsvieRVKVEHVVDVFQAVKNLRISRP-GAVETLEQ
         ......| ||.|||   .|| ||. |.. ...   . ..| || |.||.|||.|.      .. |. ..|..|.. .|  || |||.| ||
.........qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YKFCYDVTLAYL
|.|.|.. | .|
yrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 326-528 3.7e-38 126.3 In-house 2-155 (172) alignment 
Range on Protein: 326-528
Range on HMM: 2-155/172.0
DPGADYINASFAHAYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLdeedehfprywpsqgaeeyggikvelqeeddksffisrrfdiTTKGK
|.| ||||||. . |.  . || ||.||  |.|.||||. ... ..||.|..|                                          .. ..
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

STPQRICHFQVTNWSDHSVPdKPLDLLPLLNDIQTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSVIervkveHVVDVFQAVKNLRISRPGAVETLEQYKF
   . ..... ..| ||.||  .  || .|. |.. ...| .....| || ||||.|||.|.  ..      . .....||. .|  |||||.. .||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

CYD
.|.
lyy
0051429 (Phosphotyrosine protein) phosphatases II 328-535 4.8e-41 136.5 In-house 3-226 (272) alignment 
Range on Protein: 328-535
Range on HMM: 3-226/272.0
GADYINASFAHAYRE---RNAFILTQAPLEDTIASFWRMvVDYDLGTIVMLNSLDEEDEHF-PRYWP------------SQGAEEYGGIKVELQEEDDKS
  .||||..   |     .........||. |.|.|||.  .... |||.| |..| . .  .||||            |    .|| . | |..|  ..
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

FFISRRFDITTK-GKSTPQRICHFQVTNWSDHSVPDKPldLLPLLNDIQTsqqksgDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVD--------V
..| |.. .| . . ... .. |.. |.| ||.||...  || ||. ...      .....| || |..|.||..|.  ....|  | .||        .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FQAVKNLRISRPGAVETLEQYKFCYDVTLAYLD
..||. ||  |||||.| |||.|.|.. |..|.
eeaveelraqrpgavqteeqylflyeallellr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 328-528 2e-17 58.2 In-house 45-253 (290) alignment 
Range on Protein: 328-528
Range on HMM: 45-253/290.0
GADYINASFAHaYRERNAFILTQAPLEDT-------IASFWRMVVDYDLGTIVMLNSLDEEDEHF-----PRYWPSQGAE--EYGGIKVELQEEDDKSFF
  ||| |..   . .  ..||||.|.|..       | .|| |. .     .|||   .|....       .| | .  |   ..|..|. ..   .  .
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

ISRRFDITTkGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQqksgdKAIVVQCSDGVGRSGTLCAIMSVIERVK-VEHVVDVFQAVKNLRIS
. |.  ..  ..  .  . | .. .|.. .|..... || |.. ...|.      ...| | ||. || .| ||      .   .. | . ...|.||  
etRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

RPGAVETLEQYKFCYD
|  |. . ... |   
ralaitsalelafvda
0036282 (Phosphotyrosine protein) phosphatases II 329-529 2.4e-41 136.7 In-house 2-165 (174) alignment 
Range on Protein: 329-529
Range on HMM: 2-165/174.0
ADYINASFAHAYRERNAFILTQAPLEdtiasFWRMVVDYDLGTIVMLNSLDEED-EHFPRYWPSqgaeeyggikvelqeeddksffisrrfdittKGKST
 ||||||. . ..  . .|..|.||.     ||.|. .... |.|||... | . . ...|||.                               . .. 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

PQRICHFQVTNWSDHSVPDKPLdLLPLLNDIQTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSVIERVKvEHVVDVFQAVKNLRISRPGAVETLEQYKFCY
 . ..... ..| ||.||| .  || ... ... ....... ..| || ||||.|||.|.. .. . . | .||... |. ||  |||.|.| .||.|.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

DV
..
yf
0051082 (Phosphotyrosine protein) phosphatases II 329-529 3.8e-30 99.9 In-house 3-148 (151) alignment 
Range on Protein: 329-529
Range on HMM: 3-148/151.0
ADYINASFAHAYrernaFILTQAPLEdtiaSFWRMVVDYDLGTIVMLNSLDEEDeHFPRYWPSQGaeeyggikvelqeeddksffisrrfdittkgkstp
 ||||.|.   .     ......||.     |.... .... |||.|.|..| . ..|.|.|..|                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................

QRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTsqqkSGDKAIVVQCSDGVGRSGTLCAIMSVIERvkvehvVDVFQAVKNLRISRPGAVETLEQYKFCYD
 ...|.....|.|...|. .  .| .|. ..      ... ..| || |.||.|||.|.. ....      |....|.. .|..|||.| . .|. |.. 
ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

V
.
a
0049260 (Phosphotyrosine protein) phosphatases II 339-528 8.6e-34 111.8 In-house 4-144 (152) alignment 
Range on Protein: 339-528
Range on HMM: 4-144/152.0
AYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDE-HFPRYWpsqgaeeyggikvelqeeddksffisrrfdittkgkstpqricHFQVT
 |.  ..|| ||.|.. |.|.||||. ... .|||||..|.| ..  ...|.                                           ... .
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhl

NWSDHSVPDKPLDLLPLLNDIQTSqQKSGDKAIVVQCSDGVGRSGTLCAIMSVIervkveHVVDVFQAVKNLRISRPGAVETLEQYKFCYD
.| ||.||| .  || ||  |.   ... .. ..| || ||||.|||.|.  ..      . |....||. .|  |||||.. .|..|.|.
pwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 339-529 4.4e-28 92.8 In-house 231-433 (440) alignment 
Range on Protein: 339-529
Range on HMM: 231-433/440.0
AYRERNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDeeDEHFPRYWPSQG-AEEYGGIKVELQEEDDKSFFISRRFDIttKGKSTPQRICHFQVT
 |  .|||| || ||. |.  |||.| || . ||.||| |.  |     ||| .  .  .| . |  .  ..      | ...  | |   . |  |.| 
gyskknafiatqmpldstvldfwrlvhdyristiimlnqln..dktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel..kykeevheirqfevq

NWS----------DHSVPDKPLDLLPLLN--DIQTS--QQKSGDK-AIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQ
 |           .  . |  |.|.  |.  .|| |  | . ||   |.|.|  |.  || .|..| ..|... .  .|||| .. ||.|||  | || .
twptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltd

YKFCYDV
| .|| .
yllcykl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 342-533 2.7e-15 51.2 In-house 33-220 (255) alignment 
Range on Protein: 342-533
Range on HMM: 33-220/255.0
ERNAFILtqapledTIASFWRMVVDYDLGTIVMLNSLDE-EDEHFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITTK-G-KSTPQRICHFQVTN
 .| ..|       |.. |....|  .  ..|||  . | . |.  .|.| .  |     .|..   .  .  . |  .||.. | |   . . |.. . 
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykG

WSDHSVPDKPLDLLPLLNDIQTSqqksgdKAIVVQCSDGVGRSGTLCAIMSVIE----RVKVEHV--VDVFQAVKNLRISRPGAVETLEQYKFCYDVTLA
| ..  |. . ..| .|  .. |      |..||.|| |.||| ..  . .|       ..  .   .|  . ...|| .|..|..|  |  |.  ..| 
WieknaPelareilnilkvvrds......ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

Y
.
l
subfamily_hpo-7_pd Subfamily hpo-7 342-532 3e-12 41.0 In-house 36-225 (263) alignment 
Range on Protein: 342-532
Range on HMM: 36-225/263.0
ERNAFILtqapLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWPSQGAEEYGGIKVELQEEDDKSFFISRRFDITT--KGKSTPQRICHFQVTN
 .| ..|    | .||..|....|     ..|||    ||  |.  .|.| .  |     .|..   . .|  . .  ...   . | . . . |.. . 
rknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykg

WSDHSVPDKPLDLLPLLNdIqtsQQKSgdKAIVVQCSDGVGRSGTLCAIMSVIE----RVKVEHV--VDVFQAVKNLRISRPGAVETLEQYKFCYDVTLA
| ..  | .. . | .|. .    ..|  | .|| || |.|||     . .|       ..  .   .|  . ...|| ||..|..|  |  |   ..| 
Wiekndpelareilnilk.v...arns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 343-529 1.9e-24 81.0 In-house 4-199 (199) alignment 
Range on Protein: 343-529
Range on HMM: 4-199/199.0
RNAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDE-HFPRYWPS--QGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTP--QRICHFQVT
.  .| || || .|.| ||.|| .   | |||.|  . . |  .| |||.   |. .|| . |  .    |. .    . .| .  . |  . | |.| |
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

NWSDHSVPDKPLDLLPLLNDIQTSQ--QKSGDKAIVVQCSDGVGRSGTLCAIMSVI---ERVKvEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDV
 | ... |.  | .  ..   . |.  ..  |  ..|.|||| | .| . |.   .   |  |   |||.|.  | || .| | . .|..|.| |.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 344-529 2.2e-24 80.7 In-house 4-198 (198) alignment 
Range on Protein: 344-529
Range on HMM: 4-198/198.0
NAFILTQAPLEDTIASFWRMVVDYDLGTIVMLNSLDEEDE-HFPRYWPS--QGAEEYGGIKVELQEEDDKSFFISRRFDITTKGKSTP--QRICHFQVTN
  .| || || .|.| ||.|| .   | |||.|  . . |  .| |||.   |. .|| . |  .    |. .    . .| .  . |  . | |.| | 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WSDHSVPDKPLDLLPLLNDIQTSQ--QKSGDKAIVVQCSDGVGRSGTLCAIMSVI---ERVKvEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDV
| ... |.  | .  ..   . |.  ..  |  ..|.|||| | .| . |.   .   |  |   |||.|.  | || .| | . .|..|.| |.|
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 351-523 3.9e-16 53.4 In-house 98-277 (302) alignment 
Range on Protein: 351-523
Range on HMM: 98-277/302.0
APLEDTIASFWRMVVDYDLGTIVMLNSLDEE-DEHFPRYWPSQGAEE--YG-------GIKVELQEEDDKSFFISRRFDITTKGK--STPQRICHFQVTN
 |  .|.  .| .. .|. . .| | |. |. .. .  |.  .  .|  .|        .| .|.|  ||  |     .|. . |   ... .  .. . 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WSDHSVPDKPLDLLPLLNDIQtsqqkSGDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQY
| ||  |...   | .|.  .     |  |...| || ||||.||| ||   |.  . ..| |. . |. .|  | ||| . .| 
wpdhGapkeaytaldilkfce.....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 387-527 4.4e-06 20.4 In-house 152-295 (332) alignment 
Range on Protein: 387-527
Range on HMM: 152-295/332.0
RYWPSQGAEEYGgIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHS-VPDKPLDLLPL--LNDIQTSqQKSGD--KAIVVQCSDGVGRS
..|| .....     . .|  ||.|    . |..|   |   ..   ... .|.| | .|.  ||.     |. |..| .|.|     |.. |. || . 
kfwpekrskkdf.palsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadasklpeymldmrasiklqyirss.kktgvcigpimlvcatgvekc

GTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCY
   ..|  .. |.  || | . ...  ... | |.. |.  |  . 
aisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystac
0048076 (Phosphotyrosine protein) phosphatases II 388-531 2.1e-22 74.8 In-house 2-140 (145) alignment 
Range on Protein: 388-531
Range on HMM: 2-140/145.0
YWPSQGAEE--YGGIKVELQEEDDKSFFISRRFDITTKGKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSgdKAIVVQCSDGVGRSGTLC
||||.  .   .|.. . |. |  |.. | . ...|.  .   . ..... ..| ||.||| . .|| .|. |.. ...   . ..| || ||||.|||.
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

AIMSVIErvkvEHvVDVFQAVKNLRISRPGAVETLEQYKFCYDVTL
|.. ...    .. |....|.. .|  |||||.. .|..|.|.. |
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 416-528 7.4e-21 69.8 In-house 48-139 (144) alignment 
Range on Protein: 416-528
Range on HMM: 48-139/144.0
RrfdittkgkstpqrICHFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQksGDKAIVVQCSDGVGRSGTLCAIMSVIervkVEHvVDVFQAVKNLRISRPG
               ..... ..| ||.||| . .|| .|. |.. ..   .. ..| || ||||.|||.|.  ..    ... .....|.. .|  |||
e..............giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpg

AVETLEQYKFCYD
||.. .|..|...
avpnpgqlrfLle
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 423-534 1e-07 24.9 In-house 199-309 (346) alignment 
Range on Protein: 423-534
Range on HMM: 199-309/346.0
KGKSTpQRICHF-QVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSgDKAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLE
.|.|    ||.  . . |     | | | .. .. .. . .|   .  . |    | ||. ..   .  |...      .... .||..  |||.||.. 
egnsd.svicqvhhhapwkhlqqppktlpiikmihqflsekqvq.nagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfa

QYKFCYDVTLAYL
||   | . . |.
qyasiyaivfdyi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 424-533 1.2e-12 42.3 In-house 210-343 (350) alignment 
Range on Protein: 424-533
Range on HMM: 210-343/350.0
GKSTPQRICHFQVTNWSDHSVPDKPLDLLPLLN------DIQTS---QQKSGDKAIVVQCSDGVGRSGTLCAIMSVIE-----------RVKVEH---VV
  | |  . ..|| || | |.  .| ..|. |.      |  ..    ...  ..|.| || |||| |||... |...            .|..    . 
aasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktr

D-VFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
| ... |..||  |   | .|.|. |.|.  | |
DlisiivnelrkqrismvqnldqfifiYeallfy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 425-534 6.4e-08 26.3 In-house 214-344 (349) alignment 
Range on Protein: 425-534
Range on HMM: 214-344/349.0
KSTPQRICHFQVTNWSDHSVPDKPLDLLPLLN---D---IQT---SQQKSGDKAIVVQCSDGVGRSGTLCAIMSVIE--------RVKVEH---VVD-VF
.. |  .  .|| || | |.   |  .|  |.   |    .      ...   ...| || | ||.|.|. . ....         .|..      | ..
vekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlis

QAVKNLRISRPGAVETLEQYKFCYDVTLAYL
 .| .||  |   |. | |. ..|.  | |.
iivnelrkqrismvqnlaqfiaiyealLkyf
PTPc_DSPc_SM00012 433-531 3.7e-30 99.6 In-house 4-104 (105) alignment 
Range on Protein: 433-531
Range on HMM: 4-104/105.0
HFQVTNWSDHSVPDKPLDLLPLLNDIQTSQQKSG-DKAIVVQCSDGVGRSGTLCAIMSVIERVKVE-HVVDVFQAVKNLRISRPGAVETLEQYKFCYDVT
|...|.|.||.||... ..| ||........||.  | .||.||.||||.||..|.  ...... | . ||.|| || || .|||.|.|.||| |.|.. 
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral

L
|
l
subfamily_PTPDC1_pd Subfamily PTPDC1 435-529 8.6e-06 20.3 In-house 86-171 (182) alignment 
Range on Protein: 435-529
Range on HMM: 86-171/182.0
QVTNWSDHSVPDkPLDLLPLLNdIQTSQQKSGdkAIVVQCSDGVGRSGTLCAIMSVIErvkveHVVDVFQAVKNLRISRPGAVETLEQYKFCYDV
    |.|..|.     .| .   . ..  . |  .. | |  | || | | | . |       . ..  .|.| .|  || ...| || ... . 
ynfgwkDygvas.leriLdivk.vvafalqeg..kvavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvelvkef
PTEN_1 436-525 7.4e-07 24.2 In-house 99-184 (196) alignment 
Range on Protein: 436-525
Range on HMM: 99-184/196.0
VTNWSDHSVPDKPLDLLPLLNDIQTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSVIERVkvehvVDVFQAVKNLRISR-PGAVETLEQYKF
   . || .|.    .  . . |.  ....  ....| |  |.|||||..|   .  .       .. .|.. .|. | |||... .| ..
hfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.....ltadeAlelvrekRppgapnspsqerl
0038934 (Phosphotyrosine protein) phosphatases II 437-527 6.1e-07 24.8 In-house 86-170 (194) alignment 
Range on Protein: 437-527
Range on HMM: 86-170/194.0
TNWSDHSVPDKPlDLLPLLNDIQTSQQKSGDKAIVVQCSDGVGRSGTLCAIMSvIERvkvEHVvDVFQAVKNLRISRPGAVETLEQYKFCY
   .|..||.    ||  |. ...  ... .....| |  |.||.|||.|    |.|    .  .. .|.. .|. ||||... ....  .
pfpddgtvPsle.illrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.iyr...lgm.saeeAialfrekRpgaipnqdyleall
subfamily_CG42327_pd Subfamily CG42327 461-533 3.1e-13 44.1 In-house 241-314 (319) alignment 
Range on Protein: 461-533
Range on HMM: 241-314/319.0
SQQKSGDKAIVVQCSDGVGRSGTLCAIMSVIERVKVE-HVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAY
| ...    .|| |||||||.|.. |    |....   . ||. | |  .|  |  || | |||.| | |   |
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_DSP23_pd Subfamily DSP23 466-528 4.6e-08 27.8 In-house 83-140 (148) alignment 
Range on Protein: 466-528
Range on HMM: 83-140/148.0
GDKAIVVQCSDGVGRSGTLCAIMSVIERvkveHvVDVFQAVKNLRISRPGAVETLEQYKFCYD
 ..|. | |  | ||.||. |   | ||    . .   .|. ..|  |||.|||.|| |  .|
kneavsvhcllgrgrtgtmlacylvker....k.laaaeaiaevrrlrpgsvetveqeklvrd
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 468-534 1e-12 42.5 In-house 229-295 (297) alignment 
Range on Protein: 468-534
Range on HMM: 229-295/297.0
KAIVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDVTLAYL
  ..| || |||||| .   . ...... ... ||   .. ||  |.  |.||||....||..|. |
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 470-529 2.5e-13 44.2 In-house 1-60 (69) alignment 
Range on Protein: 470-529
Range on HMM: 1-60/69.0
IVVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDV
.||.|| | ||.||. |||  . |.| | .||.|  |. .|  ||  |    .| | .| 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 471-529 2.9e-13 43.9 In-house 1-59 (69) alignment 
Range on Protein: 471-529
Range on HMM: 1-59/69.0
VVQCSDGVGRSGTLCAIMSVIERVKVEHVVDVFQAVKNLRISRPGAVETLEQYKFCYDV
||.|| | ||.||. |||  . |.| | .||.|  |. .|  ||  |   ..| | .| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihda