Gene PTPN12 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP072_AA protein Get Run
NvecP072_AA_11-290 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 6-293 9.8e-77 252.9 In-house 11-301 (306) alignment 
Range on Protein: 6-293
Range on HMM: 11-301/306.0
QHKSSLEPRNNPQGENGFAKEFQELKNISsrqkRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPeIKGVDGSDYINGNYIK--GPTKNIMYLAAQG
|. | ||  ..  . .|| .||.||..        | .| ..|.|  |..||||| |||.| .|..|   ..| ||||||.||||   ....  |.|.||
qrvselekeeeslekagfeeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqg

PLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLtFAGMKISLESEeAMGDGFTVRTLAVQ---AGKTKHNVTQFHYTAWPDHDVPR
 |..|| |||||.   | .|.||. .|.| || || ||||.. |..  .  ....  ||    . ...|.| |.    .|....| |.|...||||.||.
clettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk

SATPLI----ELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYART-LLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEEL
.   ..    ...|  ...  ..  |..|||||| |||||.  .|     . ..|   .. . ..|  .|.||  .|||..|| .||||... .... 
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 11-289 8.8e-75 246.7 In-house 17-290 (298) alignment 
Range on Protein: 11-289
Range on HMM: 17-290/298.0
LEPRNNPQGENGFAKEFQELKNISSrqkRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVD
|.  .. ..  |.|.|||.|...||   . ...... ..|..|. |||| ||...|.||.|| .... . |||||  .... ...  ..|.|.||..|| 
laavkkkkkltgyalefqrlnsvss...eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetve

DFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEEtlTFAGMKISLESEEAMGDgFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPRSATPLIEL
|||||.. ..|...||     ||.|.|...|||.. .|  |.  ...|| |.| ..| ..||.|.|.  |  ....| |.|.| |||..||. || ...|
dFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefad.livrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

TRSFRTFVG-SQDTPVLVHCSAGCGRTGTICALDyaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
 |  |.    . ..||.|.|||| ||.|| .|.|    | .  . . . ||..|  ||..|...|||.|||. .|.|| | .
lrkvrasqqqagnkpvivqCsaGvgRsGtfiaid..svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
0039614 (Phosphotyrosine protein) phosphatases II 12-290 2.4e-83 275.3 In-house 23-290 (297) alignment 
Range on Protein: 12-290
Range on HMM: 23-290/297.0
EPRNNPQGENGFAKEFQELKNISSrqkrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGV-DGSDYINGNYIKGPTK-NIMYLAAQGPLPKTV
  .... . ... .||.||...          .. ..... |..|||||||||||.||..|  ..||  .||||| .|..|. . .  ..|.|||||.||
lllekansktllllefeellslkp........dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

DDFWRMMISHNIQVVVMACREYELGKlKCKRYWPESMEetlTFAGMKISLESEEAmGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELT
.|||||.  ....|.|| ... |||. || .||||...   |. .... | ..|   ||.||||| |. ..  . ||.|.|| ||||.|| |.. |.|. 
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefl

RSFRTFVGS--QDTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
.  |... .  ...|||||||||.|||||..|.... ..|...   ...|...|. ||.||  .||| .||  .|.|. ||..
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke..ggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 13-290 9.3e-78 256.5 In-house 19-284 (319) alignment 
Range on Protein: 13-290
Range on HMM: 19-284/319.0
PrnnpQGENGFAKEFQELKNISSRqkrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDF
     .||....|||..||. ..        .... .|| |..||||..||.|| .|.||.|..||.|||||| ..| |  ..  ..|.|.|| .|..||
s....tgetllekefkllkeavnd.......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedf

WRMMISHNIQVVVMACREYELGKLKCKRYWPESMeeTLTFAGMKISLESEEAMgDGFTVRTLAVQAGKTKH---NVTQFHYTAWPDHDVPRSATPLIELT
|||.  ... .||| ..  | .|.|.|.||||      ..  . . ||.|| . ... .| | ..  ...    .|..|.||.|||||||..|| |..| 
WrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeel.edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

RSFRTFVGS-QDTPVLVHCSAGCGRTGTICALDYarTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
.  |  .   |. |. |||||| ||||| ..||   .| .  . . | || .| .|| ||  |||..|||...|.|. | |.
krirksrektqsgPivvhCsaGvGRtGtfivlda..mlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
0050432 (Phosphotyrosine protein) phosphatases II 14-290 2.8e-90 298.0 In-house 35-300 (308) alignment 
Range on Protein: 14-290
Range on HMM: 35-300/308.0
RNNPQGENGFAKEFQELKNISSrqkrdkAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLpeikGvDGSDYINGNYIKGP--TKNIMYLAAQGPLPKTVDD
 ... .  .. .||.|| ..         ......... |..|||||||||||.||..|    . .|||||| .|..|.   ..  ..|.|||||.||.|
lekaldlglleeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntved

FWRMMISHNIQVVVMACREYELGKLKCKRYWPESME-ETLTFAGMKISLESEEAmGDGFTVRTLAVQA--GKTKHNVTQFHYTAWPDHDVPRSATPLIEL
||||.  .|..|.|| ....| |. || .|||.... ..|.. .... | |||   |..||||| ..   ..  . ||.||||.||||.|| |...|...
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldf

TRSFRTFVgsQDTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
 .  |..   .. |..||||||.|||||..|||..  .|...   ...||..|. ||.||  ||||.||| ..|.|. |...
lelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_PTPN23_pd Subfamily PTPN23 14-295 9.6e-59 193.5 In-house 8-286 (288) alignment 
Range on Protein: 14-295
Range on HMM: 8-286/288.0
RNNPQGENGFAKEFQELKNISSRQKRDKAFSTNhgekEYNRTKNRYKDILPYDYSRIVLPeikgVDGSDYINGNYIKGPTKN-IMYLAAQGPLPKTVDDF
|. ..|. .. |.|.||..   .. |... .      . . .|||..|||||| .|..|         ||||  ..|. .     ..|.|.||..|. ||
rkmldgktaldkkfkeleqkqdkearkrsiaia....klyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMgDGFTVRTLAVQAGKT--KHNVTQFHYTAWPDHDVPRSATPLIELTR
|.|. .   .|.||   . |||| |..|||||. .|| .|  ....|.|.. . . .  |.| ..  ..  ...|.  ..|.||.. || |   |...  
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret.ethvervlkletldadavksvshlqltsWpelGvPasPetllqfld

SFRT----FVGSQDTPVLVHCSAGCGRTGTICALDYARTLLqTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEELRK
  ..         .||..|||||| ||||... .  | . | . .   | . ..|  ||.||  |||.|||.  .|.|| | ... | |
evesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldk
subfamily_PTPN12_pd Subfamily PTPN12 15-296 4e-135 444.3 In-house 2-284 (290) alignment 
Range on Protein: 15-296
Range on HMM: 2-284/290.0
NNPQGENGFAKEFQELKNISSRQKRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWR
.. .||. ||||||.||..|...|..|..||..||||.|..|||||||||||.||..| .|....||||||.|.|||......|.|||||||||.|||||
eekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWr

MMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRT
|....|...|||||||.|||| ||.|||||..||.|.|. ....||.|.|. |.|..|||.|.| |....|.||||||||||.||.||..|.||....|.
miweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvre

FVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRT-EELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEELRKQ
.  |.|.|..||||||.||||||.|.||.|.||..... |||.|||.|..||.||.|.|||||||.||||||.|||..||.  
lqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleii
0047943 (Phosphotyrosine protein) phosphatases II 15-287 5.6e-86 283.7 In-house 6-270 (273) alignment 
Range on Protein: 15-287
Range on HMM: 6-270/273.0
NNPQGENGFAKEFQELKNISSrqkrdkAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLpeikGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWR
... | .....||..|...         ......... |..|||||||||||.||..|    | .|||||| .|..|. ..  ..|.|||||.||.||||
ekllgltllleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwr

MMISHNIQVVVMACREYELGKLKCKRYWPESMEE-TLTFAGMKISLESEEAmGDGFTVRTLAVQA--GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRS
|.  .|..|.|| ....|||. || .|||....| .||.  ... | |||   |..||||| ..    . .. ||.|||| ||||.|| | ..|.|. . 
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

FRTFVGS--QDTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
 |..  .  ...||.||||||.|||||..|||..  .|...   ...|...|. ||.||  |||| ||| ..|.|. |
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke..ggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 15-290 1.1e-60 200.0 In-house 14-284 (290) alignment 
Range on Protein: 15-290
Range on HMM: 14-284/290.0
NNPQGENGFAKEFQELKNISSrqkrdkAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGV-D-GSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDF
.. .|..|| ..|. |.. .|       .....|  . |...||...|..||  ||.| .| |  |   .|||  ||||  ..  |.|.|||...|. ||
ghakgnegfrnqfkmldsges......ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdF

WRMMISHNIQVVVMACREYELGKLKCKRYWPESmE-ETltFAGMKISLESEEAMGdGFTVRTLAVQAGKT---KHNVTQFHYTAWPDHD-VPRSATPLIE
|...  ... ..|| . . | || ||. |||.| . ..  .  ..| | .||..  ... |.| |.  ..   |..|||.. |.|.... |.  .| |. 
WkliwqekvtiivmltniieegkvkCqqYWpds.dtka..ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

LTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALdyARTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
...  .|   . .|...||||.. ||... ||.  | |. ..  .    ||... ..| |.  .|||..|| .... | . ..
ieemyktqrkrgntsivvHCSdtvgrsavfcaa..attinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 16-293 1.7e-75 248.8 In-house 16-283 (288) alignment 
Range on Protein: 16-293
Range on HMM: 16-283/288.0
NPQGENGFAKEFQELKNISSRQkrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
. ....|| .|.. | .. . .      |.. |..  | .||||..|||||. |. | . . ..|.|||| .||.|  |.  |.|.||||..||.|||..
sarnrtgfseeynsLaalektk......svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

MISHNIQVVVMACREYELGKLKCKRYWPESMEeTLTFAGMKISLESEEAMGDgFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTF
.  .... .||     | || ||..|||.. .    .  ... | ... ..| |..|.| ..  ||. ..||..|.|||||.||.|..||.|| |   . 
vyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeled.fvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkva

VGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTgrTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEEL
  ..  |..|||||| |||||  ||| .   ...  .. . |...||.||.||  .|||..||  .|... .|..|. 
nqadtgpiivhCsaGvGrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 16-293 3.4e-74 244.5 In-house 10-280 (281) alignment 
Range on Protein: 16-293
Range on HMM: 10-280/281.0
NPQGENGFAKEFQELKNISSRQKRDKAfstnhgEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
. . ..||..|...|..|  ..    .      ... |..||||..|  || .|... . .    .|||| |...| ...  |.|.|||.|.....||.|
sqndnaGfieeyeklaaigvdntatas......kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

MISHNIQVVVMACREYELGKLKCKRYWPESMEeTLTFAGMKISLESEEAMgDGFTVRTLAV-QAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRT
.........||  || | ||||| ||||.  . .|... .... ..||.    .  |.. . . .  . .|.|..||||||| || ... |.|  .  . 
vweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaeeek.atyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlk

FVGSQD-TPVLVHCSAGCGRTGTICALDYARTLLQtGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEEL
.  ..  .|...||||| |||||  ||| .   ..  ..|||.| ..||.||..|  ||||  ||. ||||| . ...||
ltekktkaplvihCsaGvGrtGtyialDrlvkave.aeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_PTPN9_pd Subfamily PTPN9 16-289 3.5e-67 221.5 In-house 11-290 (297) alignment 
Range on Protein: 16-289
Range on HMM: 11-290/297.0
NPQGENGFAKEFQELKNISSRQKrdkafsTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
. .|..|  ||..|..| .   .       .. ..  | .||||.|.| || .|.||..... . ||||| |.. |  ..  ..|.||||.|||.|||||
kekgkrGlskeyaeirnepveGt......flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrm

MISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDgFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPRSATPLIELTRSFR
.  ... |.||. |  | |.|||..|||.. |..  |. ...|  . | . | ..||.| ..  |   . .|| | ...|||. ||.||. |... .  |
vWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeed.ykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvr

TFV-------G------SQDTPVLVHCSAGCGRTGTICALDYARTLLQTgrTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
          |       .. |..|||||| ||||| ..||.. . |..  .. . |.. |  || ||  ..|| |||.. |.|| |  
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee..vgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 16-290 1.6e-60 199.5 In-house 15-279 (287) alignment 
Range on Protein: 16-290
Range on HMM: 15-279/287.0
NPQGENGFAKEFQELKNISSRQKrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPeikgVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
. .|..|| . |. |.... |..     .  |.  . |. |||...||..|  |..|         ||||  .|.|  ..  ...|..|. .|. .||..
hakgnegfknqftvleqvtqred.....evthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkl

MISHNIQVVVMACREYELGKLKCKRYWPESMEetLTFAGMKISLESEEaMGDGFTVRTLAVQAGK---TKHNVTQFHYTAWPDHD-VPRSATPLIELTRS
.  .|....|| |.| |  . .| .||||.    ...   .|.| .|| . .|...|.| |.  .   .|..|.|...|.|...  |.. .| |. . . 
iddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem

FRTFVGSQDTPVLVHCSAGCGRTGTICALDyaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
..|   . .|...||||.. ||... || .   |. .. .   . ||... . | |.  .||| |||. ....| | ..
yktqrkrgntsivvhCsdtvGrsamfcaaa..ttinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 16-289 7.6e-59 194.4 In-house 18-288 (325) alignment 
Range on Protein: 16-289
Range on HMM: 18-288/325.0
NPQGENGFAKEFQELKNISSRqkrdkAFstNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
. | ..|||.||. | .  .      |.  .   |  |. |||.|.....| ||.||   |    ||||| .|..   |  ..|||| ||..|..|.||.
kaqdqdgfahefgllpsddgi.....ak..kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrl

MISHNIQVVVMaCREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDgFTVRTLAVQAGKTK--HNVTQFHYTAWPDHDVPRSATPLIELTRSFR
..  .  |||.   | .||| .|  |||. | .. || |....| . | . | .  | | |.  |      | ||.. .|.|  |..  . || ...   
vldWrcsvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieeisd.yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvk

T---FVGS---QDTPVLVHCSAGCGRTGTICALDYArtLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
.    | .     ||.||||||| ||||.  .|  |  | .     .. .|. | .||..| .||.| .||.|.|.|. | .
avservtantkastpilvhcsaGvGrtGvfislysa..lakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
0051299 (Phosphotyrosine protein) phosphatases II 17-288 6.5e-91 300.0 In-house 19-285 (288) alignment 
Range on Protein: 17-288
Range on HMM: 19-285/288.0
PQGENGFAKEFQELKNISSRqkrdkaFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMM
. | .|...||.|| ..         ...... .. |..||||.||||||.||..|  ..||.|||||| .||.|. ..  ..|.|||||.||.|||||.
angltglleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmv

ISHNIQVVVMACREYELGKLKCKRYWPEsmEETLTFAGMKISLESEEAmGDGFTVRTLAVQ------AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTR
  .|..|.|| ....|||. || .|||.  ...||.  ... | |||   |..||||| |.       ......||.||||.||||.|| |...|... |
weqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflr

SFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
 .|..  |.. ||.||||||.|||||..|||..  .|...  ....|...|. ||.||  |||| ||| .||.|. |.
lvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0045450 (Phosphotyrosine protein) phosphatases II 17-289 6.3e-85 280.9 In-house 23-304 (307) alignment 
Range on Protein: 17-289
Range on HMM: 23-304/307.0
PQGENGFAKEFQELKNISSRQkrdkAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGV-DGSDYINGNYI--------KGPTKNIMYLAAQGPLPK
. . .|..|||..|...  .      ......... |..|||||||||||..|..|  ..|  ..|||||..|.        .|. ..  ..|.|||||.
ldfltgllkefekllsvtvfl....lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESmEETLTFAGMKISLESEEAmGDGFTVRTLAVQ---AGKTKHNVTQFHYTAWPDHDVPRSATP
||.|||||.  ....|.|| ... |||. || .|||.. .|.||.  ... | |||   ||.||||| |.     .  . ||.||||.||||.|| |  .
tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

LIELTRSFRTFVGS--QDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEE-LSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
|... .  |.....  ...|||||||||.|||||..|.... ..|... | . ......|. ||.||  .||. |||  .|.|. ||.
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPRB_pd Subfamily PTPRB 17-292 2.6e-84 277.7 In-house 21-288 (293) alignment 
Range on Protein: 17-292
Range on HMM: 21-288/293.0
PQGENGFAKEFQELKNISSRQKRDKAfstnhgEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMM
 . . .|..|..|||.. . |. ..|      |.. ||.||||..|||||.||. | ..|. .|||||| |||.| . .  ..|.|||||.||||||||.
adsdlrfseeyeelkavgkdqavkaa......elavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmv

ISHNIQVVVMACREYELGKLKCKRYWPESMEETlTFAGMKISLESEEAMgDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFV
  .. ...||  .  | || ||..|||.  |.. ..  .|..| .|| . . ...|.|... .|....|.|.|.|.||||.|| ....|....| .|. .
wekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeel.edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

--GSQDTPVLVHCSAGCGRTGTICALDyaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEE
   ....|..|||||| |||||  |||  | | .  ... . .| |||.||..|. .|||..||  ....| .|....
ektaskrPivvhCsaGvGRtGtfiald..rllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_PTPRG_pd Subfamily PTPRG 17-291 1.4e-71 236.5 In-house 15-289 (563) alignment 
Range on Protein: 17-291
Range on HMM: 15-289/563.0
PQGENGFAKEFQELKNissrQKRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGS-DYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRM
 .|. ||..||..|..    .  .| . ..| .|. |. |||| .|..|| ||. | .. |.... |||| |||.|  |.  ..|.||||..|.||||||
adgdigfseefealqs....etiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrm

MISHNIQVVVMACREYELGKLKCKRYWPEsmEETLTFAGMKISLESEEAMGDgFTVRTLAVQA-----GK---TKHNVTQFHYTAWPDHDVPRSATPLIE
.  .| ...||     | |. ||..|||.  .|..|.  ... |..|| .    ||||| ..      .|   |...|.|.||| ||||.|| ...| . 
iWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlal.ytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLi

LTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTllQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
  .   .   ..  |..|||||| ||||| ..||      |  . .   ||...  .| ||  .|||.|||. ...|. |... 
fvkkssaankaeaGPivvHcsaGvgrtGtyivldtllk..qiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Ptp69D_pd Subfamily Ptp69D 17-288 2.4e-71 235.4 In-house 18-285 (307) alignment 
Range on Protein: 17-288
Range on HMM: 18-285/307.0
PQGENGFAKEFQELKNIssrqkrDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMM
 . . |.|||...|..           ||. .||. |  ||||.|| ..|  |..|..|.| . ||||| ..|||  ..  ..|||.|.  |..|||||.
rdtdfglakeyekLear......eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

ISHNIQVVVMACREYELGKLKCKRYWPESmeETLTFAGMKISLESEEAMGDgFTVRTLAVQAGK-------TKHNVTQFHYTAWPDHDVPRSATPLIELT
   .....||   . |  . ||..|||.   ..  .  . . | ||| ..| .. |.| |   |        ...|.|.|||.|.|  ||..|. |..| 
aeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsd.yiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkli

RSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYartLLQT-GRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
.  |     . .|..|||||| ||.|.. |||    |||     .....|..| .||.||  .||  |||. .|.|. . 
eqvrelyklnrsPivvhCsaGvgrsgifvalds...llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
0036941 (Phosphotyrosine protein) phosphatases II 18-290 1.4e-87 289.0 In-house 10-278 (297) alignment 
Range on Protein: 18-290
Range on HMM: 10-278/297.0
QGENGFAKEFQELknissrQKRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLpeikGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMI
 . ... |||.||      ... . .|....... |..|||||||||||..|..|    . .||||||..|..|.  .  ..|.|||||.||.|||||. 
lflalllkefeel......lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

SHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAM-GDGFTVRTLAVQA--GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRT
 .|..|.|| ....|||. || .|||. ..|.||. .... | |.| .  |..|.||| |.   .. .. ||.|||| ||||.|| |...|... . .|.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

FVGS--QDTPVLVHCSAGCGRTGTICALDYARTLLQTG-RTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
.     ...|||||||||.||.||..|.|..  .|... ..........|  ||.||  .||| |||  .| |. ||..
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 18-291 3.1e-80 264.6 In-house 17-282 (318) alignment 
Range on Protein: 18-291
Range on HMM: 17-282/318.0
QGENGFAKEFQELknissrQKRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMI
.||  . .|...|      .. .. ... .  .. |..|||| .||.|| .|. | ...|. |||||| ||| | ...  |.|||.|||.|..|||||. 
sGelllseeyerl......srseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvW

SHNIQVVVMACREYELGKLKCKRYWPESmeETLTFAGMKISLESEEAMGDgFTVRTLAVQAGKT--KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTF
  | .|.||  .| | || |..||||..  .. ..  ... |..|  ..| ...|.. |.  ..  . .| |.|||.|||..|| |.. |..| |. .. 
eqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsd.yvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska

V-GSQDTPVLVHCSAGCGRTGTICALDYartLLQTGRT-EELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
   |. .|..|||||| ||||. .|.|    ||.  .  . . ||..| .||.|| .||||..||...|... | .. 
qqksgagpivvhCsaGvGrtGvfiavdi...llerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
0040438 (Phosphotyrosine protein) phosphatases II 19-290 8.5e-88 289.9 In-house 16-277 (317) alignment 
Range on Protein: 19-290
Range on HMM: 16-277/317.0
GENGFAKEFQELKNIssrqkrdKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMIS
. ... .||..| ..       |  .....|.. |. ||||.||||||.||..|  ..|. .||||| .|..|| ..  ..|.|||||.||.|||||.  
dftalleefedllsl.......kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

HNIQVVVMACREYELGKLKCKRYWPEsmEETLTFAGMKISLESEEAmGDGFTVRTLAVQ--AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFV
....|.|| ... |||. || .|||.  .||||. .... | |||   .|.|.||| |.   ..... ||.||||.||||.|| | ..|... .  |.. 
qgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

GSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
 ....|||||||||.|||||..|....  .|....  ...|...|. ||.||  .||| |||  .|.|. |...
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeg..gvdveeavkelreqRpgavqtpeqyrflydalleylk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 20-289 1.1e-47 157.2 In-house 14-293 (301) alignment 
Range on Protein: 20-289
Range on HMM: 14-293/301.0
ENGFAKEFQELKNISSRQkrdkafsTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVD--GSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMI
.|.|.....|||. ....       .. | .| |.. ||.|.| .||  ||.| . . .|    .||| .||.| ...  . |||||. ||. ||||...
snkfeeqykelkegedks.......ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliw

SHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEE----------------AMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDV-PR
 .  . .|| . . |  | ||..|||.| .|. .|  ... | .|                 . ..|.. |...|.. |. ..|.|.. | ||.. | . 
qekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre

SATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYArtLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
 .| |  .     .       ||.||||.. .|.|. |... .  | |  .     ||...  .||..  .|.| |||| .|..... .
prtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsig..lEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 20-289 9.8e-42 137.7 In-house 21-287 (305) alignment 
Range on Protein: 20-289
Range on HMM: 21-287/305.0
ENGFAKEFQELKNISSRQKRdKAFStnhgeKEYNRTKNRYKDILPYDYSRIVLpeiKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISH
 .|. .||. .| .   .|  |||      .  .. ||||||.   |  |. |   .|    .||  ||.  ||.   .. .| || ||  ||| | . .
paglraefvamkrfndfekm.kafk.....eaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqd

NIQVVVMACREYELGKLKCKRYWPESMEETLTFA--GMKISLESEEAMGDGFTVRTLA--------V-QAGKTKHNVTQFHYTAWPDHDVPRSATPLIEL
... . | |   | |  ||  |..   ...|.|   | |||.  | .    |.  . |        .  .|.... ||..|.  |||  || . . ..||
kveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel

TRSFRTFVGsqdtPVLVHCSAGCGRTGTICALDYARTLLQTGRTEELSvFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
    |.  |    |. |||||| ||||..  |.|    | .|.  | .   |.  .| ||   .|| .|| .|.. . . .
lekarpskg....pivvhcsagigrtgsvvmleyildqllagqiiedt.dkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 20-294 1.3e-36 121.0 In-house 5-264 (267) alignment 
Range on Protein: 20-294
Range on HMM: 5-264/267.0
ENGFAKEFQELKNISSRQKRdkaFSTNHGEKeyNRTKNRYKDILPYDYSRIVLPEIKgvdgSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISH
|  . |||...|.||. . .    |.  .||  |. .||. | |||| .|..| . .     .|||  |..|  .. .... |.|| .|. ||. ... .
eceiekefelikkisdtsst...isqsiaek..nqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdq

NIQVVVMACREyelGKLKCKRYWPESMEETLTFAGMKI--SLESEEamgDGFTVRTLAVQA-GKTKHNVTQFHYTAWPDHDVP-RSATPLIELTRsfRTF
.. |.|.  .    .. . ...||  | ..  .  . .  ||| ||   . . . || ..   .. |||| ..|  |           ||. .    .  
kvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekee...ndyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgila..knq

VGSQDTPVLVHCSAGCGRTGTICALDyarTLLQTGRTEEL-SVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEELR
.   . |..|.||.| ||.||   .|   . |.  .||.   .|| . ..| ||...|.|||.|  ... . |  .  |.
lengnrPlvvacsdGvGrsGtflvid...sqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlk
0043336 (Phosphotyrosine protein) phosphatases II 21-288 2.4e-82 271.8 In-house 20-276 (278) alignment 
Range on Protein: 21-288
Range on HMM: 20-276/278.0
NGFAKEFQELKNISSrqkrdkaFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHN
 .. .||.|| ..         ......... |..|||||||||||.||..|  ..|. .||||| .|..|. ..  ..|.|||||.||.|||||.  ..
tllllefeellsfkl.......dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

IQVVVMACREYELGKLKCKRYWPesmEETLTFAGMKISLESEEAmGDGFTVRTLAVQ--AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGS
....|| ... |||. || .|||   ...||. .... | .||   |..||||| |     . .. ||..||..||||.|| | ..|... . .|... .
vttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealed

QDTPVLVHCSAGCGRTGTICALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
...|||||||||.|||||..||... ..|....  .......|. ||.||  .||| .||  .|.|. |.
sngpvlVHCsaGvgRTGtfialyllleqlekeg..gvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 21-286 8.9e-56 183.8 In-house 10-274 (287) alignment 
Range on Protein: 21-286
Range on HMM: 10-274/287.0
NGFAKEFQELKNISsrqkRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPeIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHN
.   ||.. ||. |    .  ..     |. ..  |||| |.||.| .|..|   .|  |||||| ||. . |..  ..|||||.. || ||||... ..
ddvdkevdalkeds....esstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletr

IQVVVMACREYELGKLKCKRYWPESmEETLTFAGMKISLESEEAMGDGFTVRTLAVQAGKTK--HNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFV--
  .|..  || | ..||| .||||  |  .   |  . | . . .   ..||.| .   .|.  . | |... .|||. .. .|  || .. . . ..  
sasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

---GSQDTPVLVHCSAGCGRTGTICAL-DYARTLLQTGRTEelsVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
   .|.  |..||...| ||.|.. |.    . |...|| .   |  .|. || .| |.||.  |. |.|.|. 
ardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvd...vaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 21-292 1.2e-44 147.2 In-house 24-292 (305) alignment 
Range on Protein: 21-292
Range on HMM: 24-292/305.0
NGFAKEFQELKNISSRQKRDKAFSTNHGeKEYNRTKNRYKDILPYDYSRIVLPEIKgvdGSDYINGNYIKGPT-KNIMYLAAQGPLPKTVDDFWRMMISH
. . .||..| . .  .  ..|| .|.   . . |||||.|.   | | . | .      ||||  ||.  |   .  ...||||| .|.|.|| |.| .
dklreefrglakytrpdmtqvafnanqs.adiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqn

NIQVVVMACREYELGKLKCKRYWPESMEETLTFAGM-KIS-LESEEAMG--DGFTVRTLAVQA-GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRt
... .|| |.  ||||||| .||| .. | |.. .   .  .     |       . .| .   |. |  | ....| |||  ||      .||  . | 
kveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair.

fvGSQdTPVLVHCSAGCGRTGTICALDYARTLLQTGRtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEE
  ||.  |..|||||| |||||| |..|    .   . .   . ..|  || ||   .|.  ||  ... . . . | 
..gsk.vpivvhcsagigrtgtivaieyilekiaenk.pcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 21-284 3e-32 106.4 In-house 27-285 (310) alignment 
Range on Protein: 21-284
Range on HMM: 27-285/310.0
NGFAKEFQELKnisSRQKRDKAFSTNhgekEYNRTKNRYKDILPYDYSRIVLpEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHN
.|..|... |    ..|    .. .     . .  |||| |..  | ||. | .|      |||  ||.|       .. .|||| .|. |||||..   
eglvkqyrkld...akqdssltyeay....kkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqer

IQVVVMACREYELGKLKCKRYWPeSMEETLTFAGMKISLESEEAmgDGFTVRTLAVQ------------AGKTKHNVTQFHYTAWPDHDVPRSATPliel
 . ... |.  | |. ||  ||| |.  | |.  ....  || .  . | .  |||             |   .  |.  ..  |||  ||         
aesilllckvgeegrpkcvgywp.slgvtetygcirvtnlsess..eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch....

TRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKA
|   | .   .  |..|||||| .|.....||...   |. |  ... . .....|...|.  .||. ||... . 
tvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrg..lkvdaeevktellksraiciqtelqyliidrv
subfamily_PTPRD_pd Subfamily PTPRD 22-291 4.4e-92 304.5 In-house 21-283 (564) alignment 
Range on Protein: 22-291
Range on HMM: 21-283/564.0
GFAKEFQELKNISSRqkrdKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNI
. .| ..| |.|...    . |.... .|. |. ||||..|..|| ||.|| ...|..|||||| ..|.| .|.  |.|.||||..|..|||||.  .|.
sdlkfeeeykkieeg....qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqns

QVVVMACREYELGKLKCKRYWPESmEeTLTFAGMKISLESEEAMGDgFTVRTLAVQAG--KTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQ
...||  .  | || ||..||||. . | |. .....||.|| . | ...||. ..    . ...|.|||.|.||||.|| |||.|..| |  |.   ..
stiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeelad.yeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepd

DTPVLVHCSAGCGRTGTICALDYArtLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
  |..|||||| ||||| ...|.   | .    . . .. .|..||.|| |||||.|||  ...|. | .. 
agPivVhCSaGVGRTGtfividam..lerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
0046845 (Phosphotyrosine protein) phosphatases II 22-290 4.8e-88 290.5 In-house 1-275 (284) alignment 
Range on Protein: 22-290
Range on HMM: 1-275/284.0
GFAKEFQELKNISSRQKrdkaFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGV-DGSDYINGNYIKGP-----TKNIMYLAAQGPLPKTVDDFWRM
|. .||.|| ..   .     .|.... .. |..|||||||||||.||..|  ..|  ..||||| .|..|.      ..  ..|.|||||.||.|||||
gleeefeellsltvkll....lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrm

MISHNIQVVVMACREYELGKLKCKRYWPESmEETLTFAGMKISLESEEAmGDGFTVRTLAVQA---GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSF
.  .|..|.|| ... | |. || .|||.. .|.||. .... | |||   |..||||| ..    ..  . ||.||||.||||.|| |...|.|. |  
vweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlv

RTFVG--SQDTPVLVHCSAGCGRTGTICALDYARTLLQTGR-TEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
|..    ... |..||||||.|||||..|||.. ..|.... . ...|...|. ||.||  |||| ||| .||.|. |...
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 22-289 7e-46 151.6 In-house 17-277 (307) alignment 
Range on Protein: 22-289
Range on HMM: 17-277/307.0
GFAKEFQELKNISSRQKRDKAFSTNhgekeynRTKNRYKDILPYDYSRIVLpEIKGVdGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNI
 .  ||..| . .      .|||.|         ||||.|.   | .|||. ...|.  ||||  ||.   .|   ...||||| .|. .|| |.| ...
alvdefrvlakktpegvtveafsan.......tdknryqdvkcqdkgrivv.kfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekv

QVVVMACREYELGKLKCKRYWPESMEETLTFA--GMKISLESEEA--M---GDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRt
. |.| |.  ||.|.||..|||    ..|.|.  .  ||..   |  .    |   | || |. ..    .... .. |||. ||.     |.|  . | 
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr.

fvgSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTeELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
    .  ||.|||||| ||.||| |. . .  . .|     .. ..| .|| ||   .||. ||  ... . |  
...ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGin.ckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 22-287 1.1e-42 141.0 In-house 7-264 (283) alignment 
Range on Protein: 22-287
Range on HMM: 7-264/283.0
GFAKEFQELKNISSRQKRdkafsTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGvdgsDYINGNYIK---GPTKNIMYLAAQGPLPKTVDDFWRMMIS
..   .. ||..|  ..      ..    . |..|||...|.|.|  |. |         ||||  .|       ..  |..||.|| .|| |||.|.  
nnklfrevlkrlsvpdld.....adiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfd

HNIQVVVMACREYELGKLKCKRYWPEsmEETLTFAGMKISLEsEEAMGDGFTVRTLAVQAG---KTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTF
..|  .||  .  |  . || .|||.  . .  .  . ..|. .|   . |... | ..     |..  .. . .  | . .       |. . .     
ekitaivmltklqedlrikCsqyWPk..rGsedyGeftvtlr.kettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislq

VGSQDTPVLVHCSAGCGRTGTICALDyaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
  |...|..||||.| |||.. .|.    .. .      . || .| ..| ||. .|||..|| ||...| |
teskkgPivvhCstgiGrtavfiaas..asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
DSPc_SM00195 23-289 7.6e-86 283.1 In-house 2-262 (263) alignment 
Range on Protein: 23-289
Range on HMM: 2-262/263.0
FAKEFQELKNISSRQkrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQ
. .||..|..  | .      .|...||. |..|||||.||||| .|. |..... .|||||| |||||..|.  | |.|||||.||.|||||.. ....
lkeefekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

VVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDGFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQD
..|| ..| | || ||.|||||..... ||  ... | ..| . | ...||| ... .  ....|||..|..||||.|| |.....|| |....   ...
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

TPVLVHCSAGCGRTGTICALDYARTLLQTGRTeeLSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
.|..||||||.|||||....|..   |... .  ...|.|| .|| ||  ||||.|||. .|.|. |..
gpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 23-289 7.6e-86 283.1 In-house 2-262 (263) alignment 
Range on Protein: 23-289
Range on HMM: 2-262/263.0
FAKEFQELKNISSRQkrdkafSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQ
. .||..|..  | .      .|...||. |..|||||.||||| .|. |..... .|||||| |||||..|.  | |.|||||.||.|||||.. ....
lkeefekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

VVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDGFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQD
..|| ..| | || ||.|||||..... ||  ... | ..| . | ...||| ... .  ....|||..|..||||.|| |.....|| |....   ...
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

TPVLVHCSAGCGRTGTICALDYARTLLQTGRTeeLSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
.|..||||||.|||||....|..   |... .  ...|.|| .|| ||  ||||.|||. .|.|. |..
gpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 23-287 1.8e-52 173.3 In-house 22-277 (439) alignment 
Range on Protein: 23-287
Range on HMM: 22-277/439.0
FAKEFQELKNISsrqkRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQ
| ..|.... .|     | |  ..   .||..|||||||. ..|..|..| || ||  | ||| |||||  .. .|.|.|||  .|.|||||..| ..  
fkeifekinsts....pdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktv

VVVMACREYELGKlkckrYWPESMEETLTFAGMKI--SLESEEAMGDGFTVRTLaVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQD
 .|| .   |  |     ||| . |       ...   .|  . .  || |     . .. .. | ||||.||||..||  |. .... |.  .   ...
tivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfne.rdttekertvlqfhyiawpdknvpaqashvldflrainsandkee

-TPVLVHCSAGCGRTGTICALDYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
  ||.|||||| |||||| ||| |   |.    ... .  ||  ||.||  |||.  || ..|.|| |
ygpvvvhcsagvGrtGtiialdialeqlk..lenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
0049772 (Phosphotyrosine protein) phosphatases II 23-293 2.2e-44 147.8 In-house 18-284 (314) alignment 
Range on Protein: 23-293
Range on HMM: 18-284/314.0
FAKEFQELKNISSRQKRDKAfsTNHGEKEYNRTKNRYKDILPYDySRIVLpEIKGVDGSDYINGNYIKGPtknIMYLAAQGPLPKTVDDF----------
. |....|...| .. ...   .  . .. ||.||||.||||.| .| .|    .|.|||||| .|..|.     ..|.||||. ||.||          
llklllvlnrrslsvlpelt..ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyng

WRMMI--SHNIQVVVM---------------------ACREYELGklkckRYWPESMEETLTfagmkisleSEEAMGDGFtvrtlavqagktKHNVTQFH
|||..   .|. ..||                      ..  ..|      .....  |.|          .|   .. |            .... ...
wrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk.........eelydpelf............erlgikyl

YTAWPDHDVPrSATPLIELTRSFRTFvgSQDTPVLVHCSAGCGRTGTICALDYARTLLQtgrteeLSVFDIVANLRRQRV-----AMVQTKEQYTLVYKA
.. .||...| .   . |. . ....  ....||||||.||.||||| ....|   ||.      .|. .... .|..|       .... |||  ...|
ripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg......vsleealedvrlkRpinpnpgfieqleqyefilea

VEELVNEEL
..|...  .
lleylkflk
subfamily_PTPN13_pd Subfamily PTPN13 24-289 4.1e-73 241.0 In-house 14-269 (273) alignment 
Range on Protein: 24-289
Range on HMM: 14-269/273.0
AKEFQELKNISSRQKrdkafsTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGvdgsdYINGNYIKGPT--KNIMYLAAQGPLPKTVDDFWRMMISHNI
|.||.||... . ..      .. |.|. |..||||...|||| .|. | .  |     ||| ..|| |   ..  |.|.|||||.||.|||.|.   . 
aeefkelrelkpldt......cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqka

QVVVMACREYELGKLKCKRYWPESMEETLTFAG-MKISLESEEAMgDGFTVRTLAVQAGKT--KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGs
.|..|   | | ||.||.||||||....|.  . ....|.  . . |||.||.|||.  ..   ..|.......||||.||.||..|... .  |..   
eviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkl.dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.

QDTPVLVHCSAGCGRTGTICALDYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
. .|..|||||| ||.||. ..| .  |..  | .|. | .|| .||.|| ..||||.|| .||||. |..
dagPivvhcsaGiGrsGtlitidvvlglie..rdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN14_pd Subfamily PTPN14 26-289 3.2e-52 172.4 In-house 25-296 (300) alignment 
Range on Protein: 26-289
Range on HMM: 25-296/300.0
EFQELKNISSRQKrDKAFSTnhGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVdGSDYINGNYIKGP--TKNIMYLAAQGPLPKTVDDFWRMMISHNIQV
 |.|  .|. ... |  .||  .. . |  |||.||.|||. .|. |   |    ..|||   || .  .|.  |..|||||..|| |||.|.  ...|.
vfteyeripkkre.dallst..aklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

VVMACREYELGKLKCKRYWPES--MEETLTFAGMKISLESEEAMGDgFTVRTLAVQ--AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTR---SFRTFV
.||  .| | || |. .|.|..   ..|..|   |.. .  |  .  .. ..| ..    | . .|  . || ||||.||.  .. ..  .   | |  .
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsds.vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

GSQ------DTPVLVHCSAGCGRTGTICALDYARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
 |.      . ||||||||| |||| .   |   . |...  ||. .  ..| ||.||  .|||  ||. |||.. . .
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn..eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 28-285 1e-39 130.9 In-house 15-265 (281) alignment 
Range on Protein: 28-285
Range on HMM: 15-265/281.0
QELKNISSRQKRDKAFSTNHgekEYNRTKNRYKDILPYDYSRIVLPE-IKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVM
||. |.      | .   |.     |  |||| .|   | ||. |   .   . .|||  |||. |  .  |. .|||  .|  |||||.   |   .||
qefsnlpgdppsdlctvfnq...pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

ACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDGFTVRTLAVQAGKTKhNVTQFHYTAWPDHDVPRSATPLIELTRSFRTfvgsQDTPVLVH
 |.  |  . ||  |.|      | |  . .| |         | |      |.|.  .|.. .  ||| .|| |.  .... |  |.    . || ..|
lcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetr.lithwlwkewpdwqvpessevmlkilrkira....rstppvih

CSAGCGRTGTICALDYARTLLQTGRTEElSVFDIVANLRR-QRVAMVQTKEQYTLVYKAV
|||| ||.||. |.. |   ...  |    . .||. ||   | | ||| .|| |..| .
csagvgrsgtlmaveialqsihshftlp.dikqivshlrvtgraasvqtlqqymliwkvl
subfamily_eak_pd Subfamily eak 30-200 1.7e-12 41.4 In-house 29-196 (332) alignment 
Range on Protein: 30-200
Range on HMM: 29-196/332.0
LKNISSRQKRDKAFSTNHGEKEYNRTKNrYKDILPYDYSRIVLPEIKgVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACR
.. ..  ..  .. | . ...  .  .|   .|.|||.  . |   .  .   |||   .. .     |. .  .  . |  ||.|..  .   .|.   
inivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlle

EYELGKLKCKRYWPESMEETLTFAGMKISLESEeAMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPR
. ||.  |  .|.|.   | | |  ...   .     . . .| | .. |   |.|  ...  | . ..|.
dvelkleksdkyfpdktreelkfGildverkef.vkrniletrllelskGnethrvlhykvfGwtettlpk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 32-201 1.8e-32 107.4 In-house 14-182 (297) alignment 
Range on Protein: 32-201
Range on HMM: 14-182/297.0
NISSRQKRDKAFSTNHgeKEYNRTKNRYKDILPYDYSRIVLpeIKGVDGSDYINGNYIKGPT--KNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACR
..  ...| ..||. .  ..    ||||.||| .| .|. |   ... ..|||| .|.  |   ... |. ||||| .||||||...  ....|.|| ..
dllldeargesfssak..rnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak

EYELGKLKCKRYWPESMEETLTFAGMKIS---LESEEamGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRS
  | |. ||  |||.. .| |. . . .      |.|   |   .  | .   . .  |.   . .|||| ||  
lqedGrdkcapywpsvvqerlkagdvvveflsstsde..fdrviltelqliyrsesrvvrhvqflswpdhGvpsd
subfamily_egg_pd Subfamily egg 36-291 6.8e-31 102.1 In-house 25-272 (307) alignment 
Range on Protein: 36-291
Range on HMM: 25-272/307.0
RQKRDKAFstNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELgk
    ....  ..  .. |..| | | .   |.||. |   .|    |.|  |..||      .. || ||  ||||||||.   ..| .||     |   
esvdeisl..ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..

LKCKRYWPESMEETLTF--AGMKIS-LESEEAMGDGFTVRTLAVqAGKTKHNVTQFHYTaWPDHDVPRSATPLiELTRSFRtfvgSQDTPVLVHCSAGCG
 .|. ||| . ...| .   ...|  |. ...    |.|  | .  |  . .    |.  .  . .    .|| .. |  |       .||.|..  |. 
erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwq.gdvnnssdvyspl.rvlrklr....nlskpvvvqdilGvs

RTGTICALDYARTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
...|. |.. |   |  | .    |   |  ||..|   |..  .| .||. |  .. .
kaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_PTPN1_pd Subfamily PTPN1 37-287 5.6e-57 187.7 In-house 16-269 (290) alignment 
Range on Protein: 37-287
Range on HMM: 16-269/290.0
QKRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGvdgsDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKL
.|  . |.|.. ... ||..|||.|. |||.|||.| . .     |||| . .. .  .  |. .|||||.||| ||.|.  .. . |||  .  | ...
rkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

KCKRYWPESME-ETLTFA--GMKISLESEEAMgDGFTVRTLAVQAGKTK--HNVTQFHYTAWPDHDVPRSATPLIELTRSFRT--FVGSQDTPVLVHCSA
|| .|||.  | ..|..    .|. | |||   . .|||.| ..  ||.  .....||||.|||  ||.| . ....    |    . |.  |...||||
kcaqywPqgeeekellledtklkvkliseerk.syytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

GCGRTGTICALDYARTLLQTG-RTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
| ||.||.| .|    |..    .. . . . . .||..|. ..||..|  . | |. |
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN3_pd Subfamily PTPN3 38-289 2e-67 222.1 In-house 26-275 (280) alignment 
Range on Protein: 38-289
Range on HMM: 26-275/280.0
KRDKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKgvdGsDYINGNYIK--GPTKNIM--YLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYEL
....  ....  |  | .||||.||||||  |. | | .     |||| ||..   |.....  |.|.||||.||. |||.|.  ......||     | 
rkkpglaisaarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlver

GKLKCKRYWPEsMEETLTFAGMKISLESEeAMGDGFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGC
|. ||..|||| .|..|....... .|.| .    . .| | ..  .   .....|. |.|||||.|| ... ..|.... |.   ....||.|||||| 
GrvkChqyWPe.tedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGi

GRTGTICALDYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
|||| . .|. | .|..  ..|.. . ||| ..| || ..|||..||..| .|. .. 
grtGvlilletalalie..aaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_PTPRN_pd Subfamily PTPRN 40-292 8.6e-57 187.1 In-house 43-295 (297) alignment 
Range on Protein: 40-292
Range on HMM: 43-295/297.0
DKAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKG-PTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKC
 .  ... ...| | .|||.|..|||| ||. | |    . |||||   |     .. .|.|.||||..|| |||.|.  . . |.|. .|  | |  .|
aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

KRYWPESMEETltFAGMKISLESEEAMGDGFTVRTLAVQAGKTK--HNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGT
|||||.  .|.  .   .. | ||    | . ||.. ..  .|.    |||||. .||...|| || .|.|. |        . .|..||||.|.||||.
krywpdeGsev..yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGv

ICALDYARTLLQTGrTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEE
 ...|   . |. |   |. .   .  || ||  .|.||.|. ....|| | ||. 
yilidlvlnrllkG.vkeidiaatlehlrdqrpglvktkdqfefaltavaeevnai
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 41-287 1.9e-52 173.0 In-house 33-234 (392) alignment 
Range on Protein: 41-287
Range on HMM: 33-234/392.0
KAFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGklkckr
... .. ..|| |  |||||.||||| .|..|  |  .  |||.|  ||..   .  |.|.||| . ..||||||.  .|.  ..|  .  |        
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywpesmeetltfagmkisleseeamgdgftvrtlavqAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICAL
                                      |. .. |.|||.| |||.|||. .. |... .  ..  |.   |...||||| |||| . ..
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

DYARTllQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
|   .  .. .|  . ||..|.|.||.|  ||||||||...| || |
dsvva..hakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 42-302 3.2e-70 231.4 In-house 33-286 (315) alignment 
Range on Protein: 42-302
Range on HMM: 33-286/315.0
AFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRY
.. .. . .. | .|||||.|||.| .|..|  |     |||||  |||.  ..  |.|.||||. .|||||||.. ...  .||     |  |.||..|
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPESMEETLTFAGMKISLESEEAMGDGfTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALD
||.   ..  |  .|..| | || .|| ..| | .. ......||||..| |||. |.. .. |..| .  ..  |... ..||||||| |||| ....|
wPdrkadsvefGsikvellsleadtdg.varklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisid

yaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEElvneELRKQNHLYVN
    . |  ||. . ||..| |||..|. .|||.|.|...| || |    .|  .| | . 
..evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle....dllwrntlilv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 42-287 3.5e-59 195.7 In-house 50-289 (319) alignment 
Range on Protein: 42-287
Range on HMM: 50-289/319.0
AFSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACreyelgKLKCKRY
    .. . . |. |||. .||..| ... |  . |...|||||  ...|  .. .|.||||||. |..|||||.  .|.  .|.        | || .|
ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPESMEETLTFAGMKISLESEEAMgdgFTVRTLAVQA-GKT--KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVG--SQDTPVLVHCSAGCGRTGT
||  ....     .|...  | |    ..|| . .   ||   . ..||||.  |||. || ....|. | .  | .     . ....||||||.||||.
wplkivikeerfkvkvdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGv

ICALDYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
  .||     ..  . . . |...| .||.||  .||   || ..| |. |
yivldvlldrmk..eekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 43-294 5.3e-66 217.7 In-house 41-290 (297) alignment 
Range on Protein: 43-294
Range on HMM: 41-290/297.0
FSTNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKniMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKlKCKRYW
...   ||  |  |.|||.||||| ||. |  .     |||.|  ..||  .   ... | | . ||.|||.|.. ......||   . |  | ||.|||
qpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryW

PESMEETltFAGMKISLESEEAMgDGFTVRTLAVQAGK--TKHNVTQFHYTAWPDHDVPR--SATPLIELTRSFRTFV-GSQDTPVLVHCSAGCGRTGTI
...   |  |  . . |.| .    ||  |.| |. ||  ... | |.... |||..|.|  ||. |..|    |    . ...|.||||.|| |||| .
sdkgvtt..fGdvsvvllsvser.eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvl

CALDyaRTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE-LVNEELR
...|    . .  |..|. .|..|  ||..|. .|||||||..||.|| | |. |. |
ltid..svvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 44-290 7.1e-71 233.8 In-house 37-284 (305) alignment 
Range on Protein: 44-290
Range on HMM: 37-284/305.0
STNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWP
|.. |.|| |..|||.|.| ..| .|| | | . .| ||||| .|..|  ..  |..|||||..||.||||...   ....|| ..  | || ||..|||
sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWp

ESMEETLTFAGMKISLESEEAMGDgFTVRTLAVQA---GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFR-TFVGSQDTPVLVHCSAGCGRTGTICA
||. |.  |  ... |.||... | .. | | .      | ...|.|.. | |||| ||..|| |..| .  . .   ....|.||||||| ||||. .|
esktekkefgefsvelksektasd.yieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfia

LDYArtLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
.| |  | .  . |.. ||... .||..|. ||||..||. .. |..||..
vdia..lerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 44-287 2e-58 193.1 In-house 16-253 (284) alignment 
Range on Protein: 44-287
Range on HMM: 16-253/284.0
STNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACreyelgKLKCKRYWP
  .. . . |. |||. .||..| ... |  . |...|||||  .|.|  .. .|.|.||||. |..|||||.  .|.  .|.        | || .|||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

ESMEETLTFAGMKISLESEEAMgdgFTVRTLAVQA-GKT--KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVG--SQDTPVLVHCSAGCGRTGTIC
  ....     .|... .| .    ..|| . .   ||   . ...|||.  |||. || ....|. | .  | .     . ....||||||.||||.  
lkivikeerfkvkvdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

ALDYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
.||     ..  . . . |...| .||.||  .||   || ..| |. |
vldvlldrmk..eekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_CG7180_pd Subfamily CG7180 44-289 5.3e-51 168.0 In-house 33-290 (296) alignment 
Range on Protein: 44-289
Range on HMM: 33-290/296.0
STNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKlKCKRYWP
   .| .. || |||. ...|||| |.||....| . |||||  |. . .|.  |.  ..|  .|||.|||..  ..|. ||. ... .  | ... |||
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

ESMeeTLTFAGMKISLESEEAMGDgFTVRTLAVQAG------------KTKHNVTQFHYTAWPD-HDVPRSATPLIELTRSFRTFVGSQ-----DTPVLV
. .     .  . . . .|. . . .. ||. ..                .  |..|..| |.  . || |.. |||| |  |....         ||.|
nks..keqygeifveiveekqyan.lkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvv

HCSAGCGRTGTICALDYArtLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
..| | .|.|  .|.| .  | .  ..||. ||. |  |||.|  .|...|.|  .|  ..| |
vssdGasRsGvylaidan..lelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_ptpA1_pd Subfamily ptpA1 44-239 3.1e-42 139.8 In-house 38-248 (418) alignment 
Range on Protein: 44-239
Range on HMM: 38-248/418.0
STNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNiMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWP
 |. |.|..| .|||| .||| ...|. | .|.  .|||||| ||| |   .  ....|||||.|. |||||.     ...||  || |  ..|| ||||
etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywp

ESME-ETLTFAGM------KISLESEEAMGDG---FTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFR----TFVGSQD--TPVLVHC
| .  | ..  |         |.|  | . |       | . .      ...||..|  ||||..|  . |. .| .|        . | |   |..|||
eqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

SAGCGRTGTICA
||| |||||.|.
sagvgrtgtfct
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 44-103 1.1e-09 32.3 In-house 39-95 (95) alignment 
Range on Protein: 44-103
Range on HMM: 39-95/95.0
STNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKgvdGSDYINGNYIKGPTKNIMYLAAQG
.   |  | |  |||. .|.||| .|.||   .    |||||  .. | ...  |.||||
pytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
0040439 (Phosphotyrosine protein) phosphatases II 45-290 2.9e-77 254.9 In-house 3-247 (249) alignment 
Range on Protein: 45-290
Range on HMM: 3-247/249.0
TNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPE
....... |. ||||.||||||.||..|  ..|. .||||| .||.|.  .  ..|.|||||.||.|||||.  ..|.|.||.... |||. || .|||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

smEETLTFAGMKISLESEEAmGDGFTVRTLAVQ--AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGS--QDTPVLVHCSAGCGRTGTICAL
  ...|.. .... | |.|   |..||||| ..    .... |....|| ||||.|| |  .|... .  |... .  ...|||||||||.|||||..|.
..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DYARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
... ..|.  .. .......|. ||.||  .||. |||  .|.|. ||..
ylmleqle..kelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_PTPRA_pd Subfamily PTPRA 45-288 3.5e-69 228.2 In-house 50-294 (330) alignment 
Range on Protein: 45-288
Range on HMM: 50-294/330.0
TNHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPE
 .  .|| |. |||. .|||||.||..|....||. |||||  .|.|  .   ..|||||. .||.|||||.  .. . .||     |  . ||..|||.
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

smEETLTFAGMKISLESEEAMGDgFTVRTLAVQ------AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTIC
  | ..|.  .....| |. . | .||| . ||        |..  |.|||.|.|||  ||  .  ...| .  ..    .  |. |||||| ||||| .
..eGlvtyGnirvevedetvlvd.ytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfi

ALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
.||     ... |   . ||..| .|| ||  ||||.|||...||.. | 
vldavlervkaer..kvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
0045098 (Phosphotyrosine protein) phosphatases II 46-290 8.7e-78 256.8 In-house 26-273 (278) alignment 
Range on Protein: 46-290
Range on HMM: 26-273/278.0
NHGEKEYNRTKNRYKDILPYDYSRIVlpeikgvdgsDYINGNYIKGPtkNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPEs
... .. |. |||||||||||.||..          |||| .||.|.  .  ..|.|||||.||.|||||. ...|.|.||.....|||. || .|||| 
tpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.

mEETLTFAGMKISLESEEAMgDGFTVRTLAVQ------AGKTKHNVTQFHYTAWPDHDVPRSA--TPLIELTRSFRTFVG-------------SQDTPVL
 ...||. .... |.||| . | .|.||| |.      .. ....||..||. ||||.|| .   ....||..  | ..              ....|||
.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCSAGCGRTGTICALDYARTLLqtgrTEELSVFDIVANLRRQRVA-MVQTKEQYTLVYKAVEELVN
||||||.|||||..|... ..||     . ......|. ||.||   .||..|||  .|... ||..
VHCsaGvgRtGtlvaaylmlell....eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0042113 (Phosphotyrosine protein) phosphatases II 46-289 2.5e-75 248.3 In-house 2-243 (245) alignment 
Range on Protein: 46-289
Range on HMM: 2-243/245.0
NHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPEs
...... |..||||.||||||..|..|....|  .||||| .|..|.  .  ..|.|||||.||.|||||. ...|...|| ..| |||. || .|||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

mEETLTFAGMKISLESEEAmGDGFTVRTLAVQ--AGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVG-SQDTPVLVHCSAGCGRTGTICALDY
 .|.||. .... | |||   |..||||| |.    . ...|...||. ||||.|| .   |... .  |...  ....|||||||||.|||||..|...
.gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ARTLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
. ..|..    ..|....|. ||.||  .||| .||  .|.|. ||.
mleqleke..lgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 46-288 7.8e-74 243.6 In-house 3-241 (243) alignment 
Range on Protein: 46-288
Range on HMM: 3-241/243.0
NHGEKEYNRTKNRYKDILPYDYSRIVLpeikgvDGSDYINGNYIKGPtKNimYLAAQGPLPKTVDD----FWRMMISHNIQVVVMACREYELGKLKCKRY
... ...|..||||.||||||.||..|      .||||||.|.|... ..  . | |||||.||.|    ||||. ...|.|.|| ....|||..|| .|
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPesmEETlTFAGMKISLESEEAMGDgFTVRTLAVQA---GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTF--------VGSQDTPVLVHCSAG
||   .|. |. .... | ||| ..| .||||| ..    .. ...|...||..||||.|| | ..|... .  |.|        . ... |||||||||
wp...gev.tygdftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

CGRTGTICALDYARTLLqtgrteELSVFDIVANLRRQRVA-MVQTKEQYTLVYKAVEEL
.|||||..|...  .||      .......|. ||.||   .||| .||  .|.|. ||
vgRtGtliaaylmllll......gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRK_pd Subfamily PTPRK 46-288 3.8e-64 211.5 In-house 36-278 (314) alignment 
Range on Protein: 46-288
Range on HMM: 36-278/314.0
NHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPES
.   |. ||.|||..|||.|| ||..|  |.|   |||||...| . ..   ....||||..|| ||||..  .|   .||     | |..|| .|||| 
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

MEEtltFAGMKISLESEEAMGDgFTVRTLAVQA----GKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALD
 |    .  .|. | . |.  . . ||...|.      . .. | ||....||||||| ||| |..| |   .    .. ...||||||.||||| .|.|
tev...ygdikvelvetellae.lvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaid

YARTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE--L
    ...  | . . || .| .|| ..| ||.|.|||...| .. |  |
ivldmie..regvvdvfnavktlrsrkvnmveteeqykfiydvileacl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 46-289 6.1e-64 210.6 In-house 2-242 (250) alignment 
Range on Protein: 46-289
Range on HMM: 2-242/250.0
NHGEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLkCKRYWPes
. ..|  |. |||| ||...| ||.|| . || . |||||  ...| ... ...|.||||..|. |||||.. ......||     | .|  ...|||  
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..

MEETLTFAGMKISLESEEAMGDgFTVRTLAVQAGKTKHN--VTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGS-QDTPVLVHCSAGCGRTGTICALDY
.|.. .. ....|| |.| ..| .|.|.| .   | ...  | |.|...|||  ||. ||  .|| .  ..     ...||.|.|||| ||.|. .|.| 
vekaekyGdvtvsllskeefad.ytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

arTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
   | .  . . . ||...  ||..|. .|...|||  ||... . .
..vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 46-94 3.1e-09 30.8 In-house 32-79 (244) alignment 
Range on Protein: 46-94
Range on HMM: 32-79/244.0
NHGEKEYNRTKNRYKDILPYDYSRIVLPEIKgVDGSDYINGNYIKGPTK
       | ||||| .|||.| .|..|   |  .|||||| |||.|  .
tnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsqn
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 48-290 1.9e-69 229.1 In-house 38-277 (515) alignment 
Range on Protein: 48-290
Range on HMM: 38-277/515.0
GEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESME
 ..| | .|||||.||||| .|. |  |.    |||.|  ||..   .  |.|.|||.. .||||||... .|.  ..|  .  |  | || .|||.   
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

ETLTFAGMKISLESEEAMGDGfTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYArtLL
... |  .|..| | || ..| . |.| |  |.  . |||||.| |||. ||. .. |. | .  ..  |    |...||||| |||| ....|    . 
dsvkfGsikvelvsleactgg.ikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsv..va

QTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVN
.   |. . ||..| |.|..|. .|||.|||...| || | . 
hakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 48-301 1.3e-67 223.0 In-house 44-292 (315) alignment 
Range on Protein: 48-301
Range on HMM: 44-292/315.0
GEKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESme
  |  |. |||| .|..|| ||. || ..  ..|||.| |.|.| .|. .|.|||||.. .|.||||..  ..|  .||     |  | |...|||.   
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..

eTLTFAGMKISLESEEAMgDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDyaRTLL
  ...  . ... |||   . .|||||.|  |.  ..| |.|||.||| .||....||..| |  . .  .. ....|||||| ||||| ..||    | 
.kviyGkitvtrkseevn.teytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitld..avld

QTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAV-EELVNEELRKQNHLYV
|    . . |.... ..|..|. |||. ||| ..|.|. | .|  .    ..||.
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlyl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 48-125 1.6e-09 31.8 In-house 32-115 (347) alignment 
Range on Protein: 48-125
Range on HMM: 32-115/347.0
GEKEYNRTKNRYKDILPYDYSRIVL-PEIKG----VDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNI-QVVV
 | | . .||| ||    | .|.|| ||        |   |||  .||    .  |. .| |||.|| |||.|.   .. ||| 
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 49-291 3.8e-69 227.7 In-house 16-266 (270) alignment 
Range on Protein: 49-291
Range on HMM: 16-266/270.0
EKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTKN-IMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESME
|   ... |||.||||   .|..|.|..  . . ||| ||..| ...   |.||.|||| |. .||||..... . .||.    | |. ||.||||.. .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

ETLTFAGMKISLESE-EAMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSAT------PLIELTRSFRTFVGSQD--TPVLVHCSAGCGRTGTIC
|..... .||.  .. |.  .|. .. | ..   ...... |.|..|||| |||..        |... |  | .  ..|  .|.||||||| |||||. 
ekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

ALDYARTLLQTgrTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
|||.|  ||..  |... |  |...||..|.|.||. |||...|||| | .. 
alDiavrlLee..tkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 49-286 4.9e-50 164.8 In-house 52-280 (290) alignment 
Range on Protein: 49-286
Range on HMM: 52-280/290.0
EKEYNRTKNRYKDILPYDYSRIVLPEikGVDGsDYINGNYIKGptKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEE
.|. . .||||||.   | .|..| .  | || ||.  ||.||   . |.. .||.| .|| |.|||.. ... ..|| |   | || ||..|.||   |
dkntefkknrykdvvcndktrvilkd..GydG.dyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

TLTFAGMKISLESEEAMGDGFTVRTLAVQAGKT--KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGsqdtPVLVHCSAGCGRTGTICALDYARTL
.|||  . .    |.   .    .||.|.  ..  .| .  ..  .|||. |. |.  |. . |. |.  |    || |||||| |||||. |.. .  .
vltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqi

LQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
|  |.  || . |.|  ||. |.. ||   || .. ... 
lldGk..eldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 49-287 1.4e-46 153.6 In-house 3-238 (239) alignment 
Range on Protein: 49-287
Range on HMM: 3-238/239.0
EKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGP-TKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESme
.|  |..|||| .|. ||.||.|| ..     ||||| .|..        |.|.|| .  .  ||||||      |.||     |  | ||..|||.|  
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

eTLTFAGMKISLESEEAMGDgFTVRTLA-VQAGKTKH-NVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYarT
 |  .. ....|   | . | . .||.   | |.|.   | |.|.| |||. ||. || .. | |           | ..||||| ||||..  .|    
.tskycnlrvtlrktevfad.yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida..m

LLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
| |. . . . .|. |  .| .|  |||| ||| ... || |
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 49-286 1.6e-46 153.5 In-house 4-238 (239) alignment 
Range on Protein: 49-286
Range on HMM: 4-238/239.0
EKEYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGP-TKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESme
.|  |..|||| .|. ||.||.|| ..     ||||| .|..        |.|.|| .  .  ||||||      |.||     |  | ||..|||.|  
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

eTLTFAGMKISLESEEAMGDgFTVRTLA-VQAGKTKH-NVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYarT
 |  .. ....|   | . | . .||.   | |.|.   | |.|.| |||. ||. || .. | |           | ..||||| ||||..  .|    
.tskycnlrvtlrktevfad.yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida..m

LLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
| |. . . . .|. |  .| .|  |||| ||| ... || 
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 51-287 2.3e-38 126.8 In-house 33-268 (285) alignment 
Range on Protein: 51-287
Range on HMM: 33-268/285.0
EYNRTKNRYKDILPYDYSRIVLpeiKGVDgSDYINGNYIKGPTKN-IMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEET
| |   ||| |.   . .|.||   |  |  |||  .... | |.   |...|||||.|. |||.|.   .|  |.| |  .| |  ||  |.|| . | 
eanpdlnryadvrcieetrvvl...knhd.rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

LTFAGMKISLE-S-EEAMgDGFTVRTLAVQAGK----TKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTfVGSQDTPVLVHCSAGCGRTGTICALDYA
. |   .|.|    |||.  |  . .|.|   .        . . .   |||.  |  | |.||| .  .  |  ...|. |||||| ||| |.  .|||
vkfgkyeitlteckeeai.agtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidya

RTLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
   .      .. ..||| ..|  |.  ||.. |. ..|  . |
tirim..enpniemldivremramrfqavqshmqflflyvvlme
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 51-91 3.5e-10 33.8 In-house 45-85 (440) alignment 
Range on Protein: 51-91
Range on HMM: 45-85/440.0
EYNRTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKG
  |. ||||..|| ||.||..| |.|||  |||||  ||.|
pnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 52-287 2.2e-65 215.5 In-house 27-266 (274) alignment 
Range on Protein: 52-287
Range on HMM: 27-266/274.0
YNRTKNRYKDILPYDYSRIVLPEIKG-VDGSDYINGNYIKGPTKN-IMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEE-
 . ||||||.||| . ||..| . ..  . |.||| |||||. ..  .|.|.|||||.||.|||||.  ...||.||  .  |  . ||..|.|.. .  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

-TLTFAGMKISLESEeAMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQD---TPVLVHCSAGCGRTGTICALDYAR
 . .. ...|  |.     ....||.| ..  . ...|. . ||.||||..|..|..|..| .  ..   ...   .||.|||||| ||||   | . | 
iserygdveikveki.verndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav

TLLQtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
  |.  ... . |. ||.||| .|  ||||.||| |...|. .
rqlr..eeivvdvlkivcnlrldrGGmvqtseqyelihralcl
Y_phosphatase Protein-tyrosine phosphatase 53-286 6.9e-80 263.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 53-286
Range on HMM: 1-234/235.0
NRTKNRYKDILPYDYSRIVLpeiKGVDG-SDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLT
|..||||||||||| .|. |   || .| ||||| ||.|| ... ...|.||||..|..|||||.. ....|.|| ... | |. ||..||||..||.||
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FAGMKISLE-SEEAMGDGFTVRTLAVQAGKTKH---NVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLL
.  .|. |. .|..  ...|.|.| ..  |...    |.|.|||.||||.||.|...|..| |....   ....||.||||||.|||||..|||..   |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

QTGRTeeLSVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
.....  ..|..|| .||.||  |||. |||  .|||. 
eaeee..vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 53-286 6.9e-80 263.2 In-house 1-234 (235) alignment 
Range on Protein: 53-286
Range on HMM: 1-234/235.0
NRTKNRYKDILPYDYSRIVLpeiKGVDG-SDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLT
|..||||||||||| .|. |   || .| ||||| ||.|| ... ...|.||||..|..|||||.. ....|.|| ... | |. ||..||||..||.||
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FAGMKISLE-SEEAMGDGFTVRTLAVQAGKTKH---NVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLL
.  .|. |. .|..  ...|.|.| ..  |...    |.|.|||.||||.||.|...|..| |....   ....||.||||||.|||||..|||..   |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

QTGRTeeLSVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
.....  ..|..|| .||.||  |||. |||  .|||. 
eaeee..vdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 53-289 1.6e-52 173.0 In-house 1-171 (182) alignment 
Range on Protein: 53-289
Range on HMM: 1-171/182.0
NRTKNRYKDILPYDYSRivlpeikgvdGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACreyelgklkCKRYWPESMeetltf
|..||||.||||||.||          ..|||| |.. |. ..  ..|.||||..|| ||.||. ...|...|...         . .||||        
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

agmkisleseeamgdgftvrtlavqagktKHNVTQFHYTAWPDHDVPRsatplIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLlqtgrt
                             .....|..|. ||||.||      .. . .|   | ... |||||||||.|||||..|... ..|      
.............................erlgiqylylpwpDhgvpd.....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl......

eELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
 ..|....|. .|..|  ||.| .|| ... |. ||.
.gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 53-285 1.4e-45 150.4 In-house 3-235 (237) alignment 
Range on Protein: 53-285
Range on HMM: 3-235/237.0
NRTKNRYKDILPYDYSRIVLPEIKgvDGSDYINGNYIKGPT-KNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESmEETLT
|. |||| .|  ||.||.||       |||||| .|.||       |.||||||  . ||||.|.   .  |.||     |  .|||..|||.. ..  .
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaa

FAGMKISLESEEAMGDgFTVRTLAVQAGKTKHNV---TQFHYTAWPDHDVPRSATPLIELTRSF--RTFVGSQDTPVLVHCSAGCGRTGTICALDYarTL
.  . .||  .|.. | .|||.| ..   |...|    |...|.|||. ||. .. |. . .    |.   |. .| ..||||| |||| .  .|    |
ygvltvslkkkeefsd.ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvida..ml

LQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAV
 |.   . . ... | ..  .|  ..|||.|| ......
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 53-301 1.4e-34 114.4 In-house 43-284 (288) alignment 
Range on Protein: 53-301
Range on HMM: 43-284/288.0
NRTKNRYKDILPYDYSRIVLPeikgVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTF
| |..||...   |..|. |      |   ||. | .     .   . || ||  |.. .|.|... ... .|| |.  |.|| | . |.|  . |.  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

AGMKI-SLESEEAMGDGFTVRTLAV-QAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFrtfvGSQDTPVLVHCSAGCGRTGTICALDYARTLLQtg
  .     .. . .    .| .| . . |..|  | . |.  |.|. || .  . . |   .     | . |..||.||| |||||.     | . |.  
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslr..

RTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAV-EELVNEELRKQNHLYV
 .. |..  ..|.|| .|   .||. ||  |.. | |||.    ... ...|
lddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlredfv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 53-289 6.7e-27 88.9 In-house 47-279 (303) alignment 
Range on Protein: 53-289
Range on HMM: 47-279/303.0
NRTKNRYKDILPYDYSRIVLPEikgvdgSDYINGNYIKGPTKNIMYLaAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESmEETLTF
|  |||. |..  |.|.. | .      | ||  .|..  ...   | .| ||..|  |||.|.|  ....|..   . |  ||  .  .|.  .. | |
nmdknrfvdvicldhskvklsd......ssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflkf

AGMKISLES--EEAMGDGFTVRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATP-----LIELTRSFRTFvgSQDTPVLVHCSAGCGRTGTICALDYART
    | .    .  .|||.... |.|  |. |  .   || |||  ..|  ..|     . .|   .| .  |. || .    .||||.||.. .. |  
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrky..sdstptvymslsgcgragtfalfetahl

LLQTGRtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
 |.. .   | .   . |.|  |.  ||   |...||  . | |
slhseq.asldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 53-295 5.1e-24 79.2 In-house 51-291 (302) alignment 
Range on Protein: 53-295
Range on HMM: 51-291/302.0
NRTKNRYKDILPYDYSRIVLPEIKgvdgSDYINGNYIKGPT-KNIMYLaAQGPLPKTV---DDFWRMMISHNIQVVVMACREYELGKlKCKRYWPESMEE
|  ||. .|.  .|  .. |.. .     .|.|.  .. |  .. ..| || |  ...   ..||||. ...|. ||.. .| || |   . ..|. ...
nlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiil.aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

TLTFAGMKIS---LESEEAMGDGFTVRTLAVQAGKTK-HNVTqfHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYAR
 ...  | .     |. |.. . ...  |      .   ||.  . | |... || . . ||.   .  .   . | ....    |.|| |.. .|  | 
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvy..vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

TLLQTGrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNEELRK
. ||.|  .|  . .||...| || ..|.. .||. .| |.  .. ....|
eklqkg..kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 54-151 1.8e-26 87.7 In-house 48-159 (350) alignment 
Range on Protein: 54-151
Range on HMM: 48-159/350.0
RTKNRYKDILPYDYSRIVLP--------EIKGVDGSDYINGNYIKGP----TK--NIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCK
 .|||||.||||. ||. |.          . . ..|||| ||.| .        .  |.|.|.|||.|||||.....  ...|...   . ||.  || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPESMEETLT
|||.|   .  |
rYWqegsyddit
subfamily_CG42327_pd Subfamily CG42327 54-208 5.4e-25 82.7 In-house 29-186 (319) alignment 
Range on Protein: 54-208
Range on HMM: 29-186/319.0
RTKNRYKDILPYDYSRIVLPEIKGVDGSDYINGNYIKGPTK-NIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPES--MEETL
. |.|. ...|   .|.||..|   | . |.. .|..|. . .  |.||| .| ..  ||||..   . .|.| ..  .|||  .| .|.| .  ...| 
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

TFAGMKISLESEEaMGDGFTVRTLAVQA--GKTKHNVTQFHYtAWPDHDVPRSATPLIEL
..  ....|   |  .| . . || ..   ..   ..| . |  |.. .|| . ..|| .
lyGdilvtlkgre.vkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 54-147 1.8e-18 61.0 In-house 49-158 (349) alignment 
Range on Protein: 54-147
Range on HMM: 49-158/349.0
RTKNRYKDILPYDYSRIVLPE--------------IKGVDGSDYINGNYIKGPTKN--IMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLK
 .||||||||||..||..|..               ..    |||| ||.| .  .    |.| | ||| |||||.....  ....|.    . ||.  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CKRYWPESME
|..|| |   
cdiywqelsy
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 55-297 2.7e-27 90.3 In-house 45-285 (312) alignment 
Range on Protein: 55-297
Range on HMM: 45-285/312.0
TKNRYKDILPYDYSRIVLpeikGVDGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPE-----SMEET
  ||| .|  .|  |. |      |   ||  |..|  ||   ....|||| .|.  ||.. .|     ... |   | |  || .|  .      .|. 
dlnrypniqcwdrgrftl....agdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

LTFAGMKISLESEEAMGDGFTVRTLAV--QAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTrsfrTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLL
  .. .   .|      |  | | | |  .|   . .. .. ...|||| .| |      |     . |  .  ||. ||||| |||||.. ..   . |
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll....savkkdkkpviahcsagvgrtgtlaliesmiaal

QTGRTEElsVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV-NEELRKQN
.  | ..  | |.   ||..|   |..  ||  . ..| |.. .. | |.|
rhprkqn..vkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrn
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 63-161 1.3e-08 29.2 In-house 3-86 (130) alignment 
Range on Protein: 63-161
Range on HMM: 3-86/130.0
LPYDYSRIVlpeikgvdGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVM-ACREYElgklkcKRYWPESmeETLTFAGMKISLES
|....||.         | .||| ...    .   || .| || .|  |||.||.   . |.|.    | |        |||.|  | | .   .| . .
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee......deywpds..ePlewyeediivtl
0044763 (Phosphotyrosine protein) phosphatases II 64-290 3e-38 126.6 In-house 1-172 (178) alignment 
Range on Protein: 64-290
Range on HMM: 1-172/178.0
PYDYSRIVLPEIKGVDGSDYINGNYIKGPtkniMYLAAQGPlpktvDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEetltfagmkislesee
|.| .| .|... |. .||||| ..| .     .||....|      |.....  ..|...|. . |.|||.||| .||||...                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

amgdgftvrtlavqagktkhnvTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLlqtgrteELSVFDIVAN
                       |.... .|||.|| .   . |...  .... ... ||||||||| ||.||..|... ..|        ||...... 
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.......glsleeaiel

LRRQRVaMVQTKEQYTLVYKAVEELVN
.|..|  .|.. .|.  .|.  ..| .
vrerRp.ivpnpgqlrqLyefelrllk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 68-286 3.2e-27 90.4 In-house 33-256 (290) alignment 
Range on Protein: 68-286
Range on HMM: 33-256/290.0
SRIVLPEIKGVDGSDYINGNYIKGPTkNIMYLAAQGPLPKT-------VDDFWRMMISHNIQVVVMACREYE----LGKLKCKRYWPESMEETLTFAGMK
.|.|| . .    .|||  |... |  ..  .. | |. |.       . .|| |.   ... ||| |   |    ...  |..| |||..| |.| |..
trvvLkgygkrfnddyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

ISLESEEaMGDGFTVRTLAVQAGK-TKHNVTQFHYTAWPDHDVPRSATPLIELTRsfrtFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQtGRTEEL
..  | |   |.. .|.| |. ..  .. ||   .  | .  |...   |..| .    .|  ..|||.|||  |  |  .. |.. .  ..  . ....
vkCkske.keddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliq....kvkasktpvivHcvdGiSrsAalaaiilgyQkia.etsgsv

SVFDIVANLRRQRVAMVQTKEQYTLVYKAVE
.. |.. .||.||  ......... |  .. 
kledvlkalrkqralaitsalelafvdagiv
0051429 (Phosphotyrosine protein) phosphatases II 79-291 1.7e-47 157.7 In-house 2-227 (272) alignment 
Range on Protein: 79-291
Range on HMM: 2-227/272.0
DGSDYINGNYIKGPtknIM------YLAAQGPLPKTVDDFWRMmISHNIQVVVMACREYELGKLKCKRYWP----------ESMEETLTFAGMKISLESE
. |.||| ....|.           .....|||| |..||||.  ...| ..|. ..|.|.|.||| ||||          .....| ..  . . | ||
plsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

EAMGDgFTVRTLAVQ---AGKTKHNVTQFHYTAWPDHDVPRSAtpLIELTRSFRTfvgsqDTPVLVHCSAGCGRTGTICALDYARtlLQTGRTEELS---
| . | ...|.| .      .. . |...|||.|||| ||..|  |.|| . ...     . |||||||||..||||..||..    |. ...  .    
ellld.yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvalllll..lgvsletivddYl

-----VFDIVANLRRQRVAMVQTKEQYTLVYKAVEELVNE
     ....|. ||.|| ..||| |||  .|.|. ||...
ltnlyleeaveelraqrpgavqteeqylflyeallellrs
0046846 (Phosphotyrosine protein) phosphatases II 79-289 8e-45 148.0 In-house 10-173 (176) alignment 
Range on Protein: 79-289
Range on HMM: 10-173/176.0
DGSDYINGNYIKGPtkniMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLtfagmkisleseeamgdgftvrtlavqa
 ..||||.|.| |.    ...| |||||.|. ||..|. ...|..||. . |.|||.||| .|||| ... .                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

gktkhnvtQFHYTAWPDHDVPRSaTPLIELTRSFRTFVGSQdTPVLVHCSAGCGRTGTICALDyartLLQTgrTEELSVFDIVANLRRQRV-AMVQTKEQ
        |.... ||||.|| . . |.|| .  |... .   |||||||||.|||||..|..    ||..     |||....| .|.||   .||| ||
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llel..ekglsveealalvreqRplgavqtpeQ

YTLVYKAVEELV
|  .|... .| 
yrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 79-283 1e-42 141.1 In-house 3-155 (172) alignment 
Range on Protein: 79-283
Range on HMM: 3-155/172.0
DGSDYINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREyelgklkckrywpesmeetltfagmkisleseeamgdgftvrtlAVQA
.|||||| .|.... .   ..| ||||. |..|||||. ...|...|.....                                             . .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

GKTKHNVTQFHYTAWPDHDVPrSATPLIELTRSFRT-FVGSQDTPVLVHCSAGCGRTGTICALDYARtllqtgrtEELSVFDIVANLRRQRVAMVQTKEQ
 . .... |..|. ||||.|| ..  |.|. .  .. .. |.. |||||||||.|||||..|... .        . ||....|| .|..|  .||...|
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml........lglsleeavalvrekRpgavqnpsq

YTLVYK
| ..|.
yrflyy
0036282 (Phosphotyrosine protein) phosphatases II 80-283 3.2e-43 142.8 In-house 1-164 (174) alignment 
Range on Protein: 80-283
Range on HMM: 1-164/174.0
GSDYINGNYIKGPTKNIMYLAAQGPLPktvddFWRMMISHNIQVVVMACREYELGKLKCKRYWPEsmeetltfagmkisleseeamgdgftvrtlavQAG
|||||| .....   .  ..| ||||.     ||.|. ...|..||| ..|.|||. || .||||                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

KTKHNVTQFHYTAWPDHDVPRSATpLIELTRSFRTFVGS-QDTPVLVHCSAGCGRTGTICALDYARTLLQtgrTEELSVFDIVANLRRQRVAMVQTKEQY
  .... |..|. |||| || ... |.|. .  .... . .. |||||||||.|||||..|...  ..|    .    ..|.|. ||.||  |||| .||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvdaldlvrelRlqrpgmvqtpsQy

TLVYK
  .|.
rflyy
0051082 (Phosphotyrosine protein) phosphatases II 81-286 1.5e-34 114.1 In-house 3-150 (151) alignment 
Range on Protein: 81-286
Range on HMM: 3-150/151.0
SDYINGNYIKGPtknimYLAAQGPLPktvdDFWRMMISHNIQVVVMACREYELGklKCKRYWPESMeetltfagmkisleseeamgdgftvrtlavqagk
||||| .|. |      ... .|||.    ||.... ...|...|. . |.| |  .|..|.||                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

tkHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTfvgSQDTPVLVHCSAGCGRTGTICALDYARtlLQtgrteeLSVFDIVANLRRQRVAMVQTKEQYTL
  ..|...... |||...| |   ..|. . ..     .. |||||||||.|||||..||.     |.      .|...... .|..|  .||...|. .
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml..lg......vsleealeeyrlkrpgvvqpnqqflf

VYKAVE
...|..
qlfall
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 83-282 1.1e-33 111.3 In-house 77-275 (301) alignment 
Range on Protein: 83-282
Range on HMM: 77-275/301.0
YINGNYIKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEE-AMGDGFTVRTLAVQAGKT
 |  |.|. . .   ..|.||||..| .||| |.. .... .|| ... |  . ||. | | ...|.|     || ....|  . .  . ||| |.    
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

K---HNVTQFHYTAWPDHDVPRSATPLIELTRsfrtFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEELSvfDIVANLRRQRVAMVQTKEQ-
|   . || . |. |.|..||.| . | .|      .|   . |..|||||| ||. .  . .|    ... .| ||.  . ...|| .|   |||..| 
kfatrtvthyqysewtdrgvPkshaelfdlme....lvkksekPivvhcsaGiGrsvafigteylareveadptielt..ealkhlrehrwngvqtnsql

YTLVY
| .  
ywmtl
0049260 (Phosphotyrosine protein) phosphatases II 89-283 3.3e-42 139.1 In-house 2-144 (152) alignment 
Range on Protein: 89-283
Range on HMM: 2-144/152.0
IKGPTKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWpesmeetltfagmkisleseeamgdgftvrtlavqagktkhnvtQF
|.|  .. ...|.|||.| |..|||||. ...|...|| ....|||||||..|.                                            |.
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qy

HYTAWPDHDVPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARtllqtgrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYK
... |||| || ..  |..| .  . .  ... |||||||||.|||||..|... .          .|....|| .|..|  .|....|. ..|.
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 93-188 5.8e-09 29.8 In-house 233-323 (440) alignment 
Range on Protein: 93-188
Range on HMM: 233-323/440.0
TKNIMYLAAQGPLPKTVDDFWRMMISHNIQVVVMACreyELGKLKCKRYWPESMeETLTFAGMKISLESEEAMgDGFTVRTLAVQAGKTKHNVTQF
.|.  ..|.| ||  || ||||..  ..|  ..|     .|    |  |||     ..||  . .     | | .   |||| ..  .  |.. ||
skknafiatqmpldstvldfwrlvhdyristiimln...qlndktcsiywpvnt.rsvtfgpftvghkgsenm.nrvkvrtlelkykeevheirqf
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 97-283 7e-18 59.5 In-house 5-197 (198) alignment 
Range on Protein: 97-283
Range on HMM: 5-197/198.0
MYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDgFTVRTLA----VQAGKTKHNVTQFHYTA
 |.|.| || .|. |||.|.       .||   .    .     ||| .   |  .. . .. ..  .  | .|. .|     . |  .  ..... .|.
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpd.ytitaliltnnttappstreishyqfts

WPDHDVPRSATPL--IELTRS-FRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYK
| ..  |  |  .  .  .|   . .   .|.||.|||| | | || . |||      .  .|  . .|..   ||. |. .. . ..| ..|.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 97-283 7.5e-18 59.4 In-house 6-198 (199) alignment 
Range on Protein: 97-283
Range on HMM: 6-198/199.0
MYLAAQGPLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMGDgFTVRTLA----VQAGKTKHNVTQFHYTA
 |.|.| || .|. |||.|.       .||   .    .     ||| .   |  .. . .. ..  .  | .|. .|     . |  .  ..... .|.
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpd.ytitaliltnnttappstreishyqfts

WPDHDVPRSATPL--IELTRS-FRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYK
| ..  |  |  .  .  .|   . .   .|.||.|||| | | || . |||      .  .|  . .|..   ||. |. .. . ..| ..|.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_hpo-7_pd Subfamily hpo-7 98-295 2e-19 64.5 In-house 41-233 (263) alignment 
Range on Protein: 98-295
Range on HMM: 41-233/263.0
YLaaqgpLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAmgdGFTVRTLAVQA----GKTKHNVTQFHYTAW
 |     | .|.| |....   . .|||| |  .| |. ||..|.|   .| . .| ....            ..|| .       |. |.|... |. |
sl.....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgW

PDHDVPRSATPLIELtrsFRTFVGSqdTPVLVHCSAGCGRTGTICALDYART----LLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
...  |. |   ...   ..   .|   .. ||||.| ||.      . .       |.|  | ||    .. .|| .| . ..|  |       | ..|
iekndpelareilni...lkvarns..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv

NEELRK
 ..  |
lnnfak
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 99-289 1.7e-22 74.7 In-house 39-221 (255) alignment 
Range on Protein: 99-289
Range on HMM: 39-221/255.0
LaaqgplpkTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESeeAMGDgFTVRTLA--VQAG--KTKHNVTQFHYTAWP
|        ||| |.....  . .|||| |  .| |. ||..|.|   .| | .| ....     .. |   .|||    . |  |  |.|. ..|. |.
l........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssad.vvlrtleitstlgekkkthtvkhysykGWi

DHDVPRSATPLIELtrsFRTFVGSqdTPVLVHCSAGCGRTGTICALDYART----LLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEELV
..  |. |  . ..   ..    |   .|.||||.| ||. .    ...       |.|  | ||    .. .|| .| . ..|  | ..    | .||
eknaPelareilni...lkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 104-282 2.7e-26 86.8 In-house 99-281 (302) alignment 
Range on Protein: 104-282
Range on HMM: 99-281/302.0
PLPKTVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTFAGMKISLESEEAMG------DGFTVRTLAVQAG----KTKHNVTQFHYTAW
|  .|.. .| ..  .|. .||  |   | .. ||  |. . ....|.|    .   | .          .|.. |. ..      |.|. |  ....||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHDVPRSATPLIELTRsfrtFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEELsvFDIVANLRRQRVAMVQTKEQYTLVY
|||  |. | . ... .    |  |  . |||||||| |||||. |. |   | .. .. .|   .||  .|. |   ||...| . . 
pdhGapkeaytaldilk....fcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdl..lsivlpvrqcryGavqdeqqliyll
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 108-288 2.3e-11 36.9 In-house 130-308 (346) alignment 
Range on Protein: 108-288
Range on HMM: 130-308/346.0
TVDDFWRMMISHNIQVVVMACREYELGKLKCKRYWPESMEETLTfAGMKISLESEEAMGDGFTVRTLAVQAGKTKHNVTQFHYT-AWPDHDVPRSATPLI
 |.||| |.   .|..| .   .  | .     .  |      |   | |     .  ||        .  |..   . | |.   |   . |  . |.|
fvedfwymiyqeqihlvylmvpddklkntttslfndenggyqyt.gkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpii

ELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
 .   | .    |.. | |    ||||. ..    ||   |. |   |  ...|. |...||   |..  ||. .|  | . 
kmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngi..epniceimknikqqrpggvesfaqyasiyaivfdy
0048179 (Phosphotyrosine protein) phosphatases II 114-283 2.9e-25 84.1 In-house 23-139 (144) alignment 
Range on Protein: 114-283
Range on HMM: 23-139/144.0
RMMISHNIQVVVMACREYELGKLKCKrywpesmeetltfagmkisleseeamgdgftvrtlavqagktkhnVTQFHYTAWPDHDVPRSATPLIELTRSFR
 .. ...|  |.  . |||   |..                                              ..|.... ||||.|| ... |.|. . ..
ellkklgittvinlteeyepeflere.............................................giqylhlpwpDhgvpdllellleflefie

TFVGsQDTPVLVHCSAGCGRTGTICALDYARtllqtgrTEELSVFDIVANLRRQRVAMVQTKEQYTLVYK
...  .. |||||||||.|||||..|..  .       .. ||.....| .|..|  .|.. .|.  ...
eale.eggpvlVHCsaGvgRtgtlvaaylmk.......klglsleealalvrsrrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 141-288 8.7e-27 89.0 In-house 2-142 (145) alignment 
Range on Protein: 141-288
Range on HMM: 2-142/145.0
YWPESMEETLTFAGMKISLESEEAMGDGFT-VRTLAVQAGKTKHNVTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQdTPVLVHCSAGCGRTGTICA
|||    . | . ..   |. |.    |.| | .|.      .....|..|. ||||.|| ..  |.|. .  .... .   |||||||||.|||||..|
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlva

LDYARTllqtgrtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEEL
..  ..       . .|...... .|.||  .|.. .|.  .|....||
aylmll.......lgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 182-287 1.7e-20 67.8 In-house 88-192 (440) alignment 
Range on Protein: 182-287
Range on HMM: 88-192/440.0
KHNVTQFHYTAWPDHDVPRSATPLIELTRSFRT-FVGSQDTPVLVHCSAGCGRTGTICALDYarTLLQTGRTEELSVFDIVANLRRQRVAMVQTKEQYTL
 . . |.|| .|||. ||. | |.... .        . . |.|||||||.|||| | |.|    | .. |.... .| .. ..| .|  |||| |||..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavds..ilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

VYKAVEE
|..|| |
vheavle
PTEN_1 182-283 1.4e-09 33.0 In-house 91-187 (196) alignment 
Range on Protein: 182-283
Range on HMM: 91-187/196.0
KHNVTQFHYTAWPDHDVPRSAtPLIELTRSFRTFVGS--QDTPVLVHCSAGCGRTGTICAldyaRTLLQTGRteeLSVFDIVANLRRQR-VAMVQTKEQY
...  ...   ..|| .|  .  |..  .||   . |  .   ||||| || ||.||..|      |...|.   |.. . .. .|..| ...... .| 
fksgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva....ayLmykgk...ltadeAlelvrekRppgapnspsqe

TLVYK
 |.. 
rlley
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 183-288 8.7e-19 62.4 In-house 215-343 (350) alignment 
Range on Protein: 183-288
Range on HMM: 215-343/350.0
HNVTQFHYTAWPDH---DVPRSATPLIE-------LTRSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYART---LLQ--TGRTEEL--------SVFD
. | |...  |.|      |.|  . .|          .   .  .. .|.|||||||.|||||...||.       |.  | . ..|         .. 
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

IVANLRRQRVAMVQTKEQYTLVYKAVEEL
|| .||.||. |||...|.  .|.|.  .
ivnelrkqrismvqnldqfifiYeallfy
subfamily_PTPDC1_pd Subfamily PTPDC1 183-282 3.4e-08 28.2 In-house 80-169 (182) alignment 
Range on Protein: 183-282
Range on HMM: 80-169/182.0
HNVTQFHYTAWPDHDVPrSATPLIELTRSFRTFVGSQdtPVLVHCSAGCGRTGTICAldyaRTLLQTgrtEELSVFDIVANLRRQRVAMVQTKEQYTLVY
..   ..  .|.|..|. | . .... .     .  .   | ||| || |||| . |      |. .   ..|.  . .  .| .|   .||.||  || 
eqgiyvynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvlia....cylvya...krltaekaiklvrskrpksiqtreqvelvk
DSPc Dual specificity phosphatase, catalytic domain 184-239 4.8e-06 21.5 Pfam-A 36-92 (133) alignment 
Range on Protein: 184-239
Range on HMM: 36-92/133.0
NVTQFHYTAWPDHD-VPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICA
. ....|.  | .|      .. .| . .|   . ..   ||||| ||  |..|...
kkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 184-239 4.8e-06 21.5 In-house 36-92 (133) alignment 
Range on Protein: 184-239
Range on HMM: 36-92/133.0
NVTQFHYTAWPDHD-VPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICA
. ....|.  | .|      .. .| . .|   . ..   ||||| ||  |..|...
kkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
PTPc_DSPc_SM00012 185-285 2.8e-32 106.4 In-house 2-103 (105) alignment 
Range on Protein: 185-285
Range on HMM: 2-103/105.0
VTQFHYTAWPDHDVPRSATPLIELTRSFRTFVGSQD--TPVLVHCSAGCGRTGTICALDYARTLLQTGRtEELSVFDIVANLRRQRVAMVQTKEQYTLVY
|...|||.|||| ||.......|| |.....   ..  .||.||||||.|||||..|||..   |.... .|...|.||  ||.||  ||||.|||  .|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeqylfly

KAV
.|.
ral
PTPc_motif_SM00404 185-240 4.3e-06 21.6 In-house 44-100 (140) alignment 
Range on Protein: 185-240
Range on HMM: 44-100/140.0
VTQFHYTAWPDHD-VPRSATPLIELTRSFRTFVGSQDTPVLVHCSAGCGRTGTICAL
  .|..   | .|      .. .. . .|   . .. . ||||| ||  |..|... 
nsgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia
0038934 (Phosphotyrosine protein) phosphatases II 186-290 1.5e-08 30.0 In-house 80-178 (194) alignment 
Range on Protein: 186-290
Range on HMM: 80-178/194.0
TQFHYTAWPDHDvprsATPLIELTRSFRTFV-----GSQDTPVLVHCSAGCGRTGTICALDYARTllqtgrtEELSVFDIVANLRRQRVAMVQTKEQYTL
 ...   .||.     ..| .|....|  .|      ...  |.||| || |||||..|     .         .|. . .| .|. |  .... ...  
ieylklpfpddg....tvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.......lgmsaeeAialfrekRpgaipnqdylea

VYKAVEELVN
..| ..|| .
llkrykelrk
subfamily_VSP_pd Subfamily VSP 191-259 9.6e-07 22.9 In-house 99-167 (212) alignment 
Range on Protein: 191-259
Range on HMM: 99-167/212.0
TAWPDHDVPRSaTPLIELTRSFRTFVGSQDTPV-LVHCSAGCGRTGT-ICALDYARTLLQTGRtEELSVFD
    ||.||.    |. .|. .. ..  .   |  .||  | ||||| .|||  |  ...| . | |  | 
iliddhnvpkl.eellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetak.esldyfg
subfamily_PTEN_pd Subfamily PTEN 192-263 9.2e-06 20.8 In-house 86-157 (184) alignment 
Range on Protein: 192-263
Range on HMM: 86-157/184.0
AWPDHDVPRsATPLIELTRSFRTFVGSQDTPV-LVHCSAGCGRTGTIC-ALDYARTLLqTGRTEELSVFDIVAN
   ||  |.    | |. .. .... .... |  ||| || ||||..  |. . ..|| .  .| |..|. .  
pfdDhnppp.lelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslll.ekaeealelfaeaRt
Y_phosphatase3 Tyrosine phosphatase family 208-240 3.2e-06 22.2 Pfam-A 113-144 (164) alignment 
Range on Protein: 208-240
Range on HMM: 113-144/164.0
LTRSFRTFVGSQdTPVLVHCSAGCGRTGTICAL
... ....  .. .|||.||.||  ||| ..||
yrkvlealaeee.gpvlfHCtaGKDRTGvvaal
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 210-285 2.1e-13 44.3 In-house 255-340 (349) alignment 
Range on Protein: 210-285
Range on HMM: 255-340/349.0
RSFRTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEE--L--------SVFDIVANLRRQRVAMVQTKEQYTLVYKAV
 .   .  .| ...||||||||||||... ||.   .|.  . |   .         .. || .||.||..|||   |.  .|.|.
farlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal
subfamily_CG42327_pd Subfamily CG42327 213-287 1.5e-15 51.7 In-house 240-313 (319) alignment 
Range on Protein: 213-287
Range on HMM: 240-313/319.0
RTFVGSQDTPVLVHCSAGCGRTGTICALDYARTLLQTGRtEELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
|.   ..  |. |||| | ||||.. | | |   |.. . . . . ..|  .||.|   |.||||| ..|| . |
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleesk.rsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 219-287 4.9e-13 43.6 In-house 227-293 (297) alignment 
Range on Protein: 219-287
Range on HMM: 227-293/297.0
QDTPVLVHCSAGCGRTGTICALDYARTLLQTGRTEElsVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
.....||||||| ||.| .   |   . |. .|  .  |  |.  || ||  .||| ||..|.|.|| .
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripd..vaailsilreqrarlvqtleqfellydavlk
subfamily_DSP23_pd Subfamily DSP23 219-283 1e-07 26.7 In-house 83-140 (148) alignment 
Range on Protein: 219-283
Range on HMM: 83-140/148.0
QDTPVLVHCSAGCGRTGTICALDYArtllqtgRTEELSVFDIVANLRRQRVAMVQTKEQYTLVYK
..  | |||  | |||||. |  .        . ..|.  . .|..||.|   |.| ||  ||..
kneavsvhcllgrgrtgtmlacylv.......kerklaaaeaiaevrrlrpgsvetveqeklvrd
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 224-287 4.5e-07 24.2 In-house 2-63 (69) alignment 
Range on Protein: 224-287
Range on HMM: 2-63/69.0
LVHCSAGCGRTGTICALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
.||||.| |||||. |.    . ... .   . .|. |  .|. |  ||  . .| ... |. |
vvhcssgtgrtgtfiaimvemariksek..lvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 225-287 5.5e-07 23.8 In-house 2-62 (69) alignment 
Range on Protein: 225-287
Range on HMM: 2-62/69.0
VHCSAGCGRTGTICALDYARTLLQTGRteELSVFDIVANLRRQRVAMVQTKEQYTLVYKAVEE
||||.| |||||  |.    . ... .   . .|. |  .|. |  ||  ...| ... |. |
vhcssGtGrtGtfiaimvemariksek..lvdifnnvqymrkcrpmmvmneneymfihdalve