Gene PTPN13 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN13
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP073_AA protein Get Run
NvecP073_AA_18-291 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 19-292 9.4e-98 322.6 In-house 31-301 (308) alignment 
Range on Protein: 19-292
Range on HMM: 31-301/308.0
LTGALQTKLDSGMPEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLsgSSGEDYINANHIRVLVDDDTYHYIATQGPLPNTTKDFWQMI
|  .|. .||.|. ||||..|...||   ..... ..| |||||...|||. .||.|  ..| |||||..... . . . ..||||||||||..|||.|.
llkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmv

WEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRS
|||.|.|. |.|   | |..||..|||.....  .  |.| | ||.....|....| . ...|..|.|... |. .  ||||||| || ....|. ..|.
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrk

LAtSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
   .. |.|||||||.||||..||.|..| ..|... .|. .... ||||| ||.||..||.|.|.|.|| ||.
sl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_PTPN13_pd Subfamily PTPN13 21-293 1.1e-145 479.0 In-house 2-272 (273) alignment 
Range on Protein: 21-293
Range on HMM: 2-272/273.0
GALQTKLDSGMPEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSGedYINANHIRVLVDDDTYHYIATQGPLPNTTKDFWQMIWE
 |||.|||...|.||||.|||.||.| |..||...|.|||||||||||..|||.|....|  ||||..|.| |..|.|.|||.|||||.|.||||||.||
aalqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvwe

QGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLA
| .||.|||||.||.||||||||||...|..||. .|.||.|||....|.||.|..|||...||.|.|.||||||||||||||.|..|..||||..|.|.
qkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq

TSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSL
|...|.||||||||||.|.||..||.|||.||||.||.....|.|||||||..||||||||.|||.|||||||
tdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlksl
subfamily_PTPN3_pd Subfamily PTPN3 22-290 1.5e-87 288.1 In-house 7-275 (280) alignment 
Range on Protein: 22-290
Range on HMM: 7-275/280.0
ALQTKLDSGMPEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSGeDYINANHIRVLVDDDT--YHYIATQGPLPNTTKDFWQMIW
 |.  |.||.   .|. |   ||   ..  .  .| .|||||..|||.||||.|. |.  ||||||.. . ..  .   .||||||||..|..|||||.|
llkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvw

EQGVEVVAMVTLDKEGGKVKCHRYWPDnTNQPLKLGgRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSL
|| .... |.|   | |.||||.|||. |.. |..| .|.| . |. .  |.| |.. .|. .. .. .| .| .. ||||||| .. ....||  .|.|
eqksslivmlttlverGrvkChqyWPe.tedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl

A-TSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
  ... |||||||||||||| ||....|| |.|. .|. . . .| .|.||. ..||..|| |  .| |.| 
rsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_PTPN14_pd Subfamily PTPN14 22-292 1.1e-76 252.7 In-house 15-298 (300) alignment 
Range on Protein: 22-292
Range on HMM: 15-298/300.0
ALQTKLDSGMPEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSS--GEDYINANHIRVLVDDDTYHYIATQGPLPNTTKDFWQMIW
 |. ||..|.   |.  . . .    ....|.. |..|||...||||| .||.|| .    ..|||| .|.| |   ...||..||||..| .|||||.|
ilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvW

EQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKL-GGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRS
||||....|.| ..|.|| |...|.|.....  ..  |.|.|.   ... ||.. . . .||| |..  .. || .. |||||||. . ......  ..|
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

LAT----------SQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
.            |. ||.||||||.|||| || .|. .  .| ..  ||..... |||||. ..||  || | ||. .. ||.
vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
0039614 (Phosphotyrosine protein) phosphatases II 23-292 3.9e-84 277.9 In-house 25-291 (297) alignment 
Range on Protein: 23-292
Range on HMM: 25-291/297.0
LQTKLDSGMPEEEFKDLREIKPtDgCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG----EDYINANHIrvLVDDD-TYHYIATQGPLPNTTKDFWQM
| ....... ..||..| ..|| | .  .. ..| |||||...|||. .||.|..  |     |||||...   . |  | ..||||||||.|..|||.|
lekansktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlpetvedFwrm

IWEQGVEVVAMVTLDKEGGKvKCHRYWPDNTNqplkLGGRFEVSLLKQTNYDSFVQRDIAVKHlqSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMR
.|||||.|. |.|  .| |. ||..|||....      |.| | ||| . .| ...| . |..  .|.| .. |. ...||||||| |.  . .|. ..|
vweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvr

SLAT---SQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
.      .. ||.||||||.||||..|| . .| ..|. . .|. .... ||||| |..|| .||.|.|.| || || 
ealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 23-292 5.2e-81 266.8 In-house 9-278 (281) alignment 
Range on Protein: 23-292
Range on HMM: 9-278/281.0
LQTKLDSGMpEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLS---GSSGEDYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIW
|... ..|.  ||...|..|   .   . |...|. ||||.|.  |.||||...    ..  ||||||..  . ..   .|||||||.|.. ..||||.|
lsqndnaGf.ieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgek..eyiatqgPvPaslvafWqmvw

EQGVEVVAMVTLDKEGGKVKCHRYWPDNTnQPLKLGgRFEVSLLKQTNYDSFVQRDIAVkHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSL
|| |....||| . |.||.||||||||.. . ||.|  . |. .....  ....| . . . .||.. |...|....||||||| .. |...| . ...|
eqkvsaivmvtreieagklkChrYWPddn.selkyg.dvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkl

ATSQA--PVVVHCSAGIGRTGALIAVDVALGLMERD-KPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
 ...   |.|.|||||.||||. ||.| ..  .|.. .. |.......||..|. |.||  || | |||.|..|. 
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 23-292 1.9e-62 206.1 In-house 19-286 (297) alignment 
Range on Protein: 23-292
Range on HMM: 19-286/297.0
LQTKLDSGMPEEEFKDLREIKPTDGcDSGKNQANTDKNRYRNVLPYEATRVRLSGSSGE---DYINANHIRVLVDddtyHYIATQGPLPNTTKDFWQMIW
.|.. .. . .|||..| | . . .    ... | .|.||.|.|||.  ||.|     .   ||.|| ....       ..|.|| | ..| .|||.|..
vqknrhtdvfseeflclpeaniqpq.tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvl

EQGVEVVAMVTLDKEGGKvKCHRYWPDNTNQPlklGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPR--SPVEMVQFVAYMR
.. | ...|.. |.|. | || |||.|.. ..    |   | ||  ..   |..|.. |.. .. .   .   .||.|||. |.|  |   .....  .|
deqvstivmlnddnerdk.kcaryWsdkgvtt...fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevr

SLAT--SQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
      ...|..|||.||.|||| |...|  .  ..|.|  || .... ||..|  ..|||.|| | |.| ||.| |
kdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
0047943 (Phosphotyrosine protein) phosphatases II 24-290 2.4e-89 294.7 In-house 6-272 (273) alignment 
Range on Protein: 24-290
Range on HMM: 6-272/273.0
QTKLDSGMPEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLsGSSGEDYINANHIRVlvDDDTYHYIATQGPLPNTTKDFWQMIWEQGV
...|.... .|||..|...||   .  .. ..| |||||...|||. .||.| |..| |||||.....   . . ..||||||||||..|||.|.|||.|
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdg..ynlkrkfiatqgPlpntvedfwrmvweqnv

EVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT--
.|. |.| . | |..||..|||.. ..  .  |.| | ||.....|....| . ...|..|.| .. |. . .||||||| |. ....|. ..|.     
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-SQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
 |. |||||||||.||||..||.|..| ..|. . .|. .... ||.|| ||.|| .||.|.|.| || |
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 24-289 2.4e-23 77.0 In-house 20-284 (302) alignment 
Range on Protein: 24-289
Range on HMM: 20-284/302.0
QTKLDSGMPEEEFKDLREIK-PTDGCDSGKNqaNTDKNRYRNVLPYEATRVRLSGSsGEDYINANHIRVlvDDDTYHYIATQGPLPNTT---KDFWQMIW
 ..||..  ..||| . ..| ... | . |.  |..||.  .|  .....|.|...  ..|.|| .. |   . |.  | .| |  ...    .||.|..
vksldtaevkkefkkidtmkvdlekCkafkk..nlkknqsedvpildsnlvkleae.pdsyvnaskvev..PeltrsiilaQlpkvdsedsveeFWrmvf

EQGVEVVAMVTLDKEGGKvKCHRYWPDNTNQPLKLGgRFEVSLLKQTNYDSFVqRDIAVKHLQSGKS--IEIAHLNFVKWPDHGVPRSPVEMVQFVAYM-
.. .  | ..  ..|  |   . ..| .... .. | .. |   |  . .  .    ..  |  | |  . .    .  |... || .  |... .| . 
qekivsvvilvgeeelkk.tlselfpkksgdykeyg.kmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvf

RSLATSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
 . . .....|.    |.|| ||.... ||.  ....|   |..... .|.||  .... .||.. | | |  
akkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
0040438 (Phosphotyrosine protein) phosphatases II 25-292 1.1e-87 289.5 In-house 13-278 (317) alignment 
Range on Protein: 25-292
Range on HMM: 13-278/317.0
TKLDSGMPEEEFKDLREIKPTdGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG---EDYINANHIRVlvDDDTYHYIATQGPLPNTTKDFWQMIWEQ
 |.| ....|||.||...|.   .. .. ..| |||||...|||...||.||  .|    |||||... .   . . ..||||||||||. |||.|.|||
lksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdg..pnlkrkfIatqgPlpntvedFwrmvweq

GVEVVAMVTLDKEGGKVKCHRYWPDntNQPLKLgGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT
||.|. |.|  .| |..||..|||.  ...|.  |.| | ||. . ..... | . |..|....| .. |. .  ||||||| || ....|. ..|.   
gvtvivmLteleelgrekcaqYwpl..getlty.gdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

S-QAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
. . ||.||||||.||||..||....| ..|. . .|. .... ||||| |..|| .||.|.|.| || || 
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_PTPN9_pd Subfamily PTPN9 25-290 1.6e-73 242.3 In-house 12-290 (297) alignment 
Range on Protein: 25-290
Range on HMM: 12-290/297.0
TKLDSGMpEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSS---GEDYINANHIRVLVDDDTyhYIATQGPLPNTTKDFWQMIWEQ
 |  .|.  .|....|. ...   .  | .||  |||| .|| |. ||| |.  .     ||||||..      ..  .|||||||..|..|||.|.|||
ekgkrGl.skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkka..fiatqGplkktvsdfWrmvWeq

GVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLgGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLA-
 | |. |.|   | |..|| .|||.....  .  | ..|| ... ... ...| . .|. . ..| .. |  |. |||.|||.|  ......  .|.   
evlvivmttrvvergrlkcgqyWpleeessaef.gdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

-------------TSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
             .|. |.||||||||||||..|..|..|  .|.    |. .|.. ||.||  .||| .|| |||.| ||  
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0036941 (Phosphotyrosine protein) phosphatases II 26-292 1.2e-88 292.6 In-house 9-279 (297) alignment 
Range on Protein: 26-292
Range on HMM: 9-279/297.0
KLDSGMPEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLsGSSGEDYINANHIrvLVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEV
.|.. . ..||..| ....   .. .....| .||||...|||. |||.| ...| |||||...   . | ....||||||||||. |||.|.|||.|.|
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmvweqnvtv

VAMVTLDKEGGKVKCHRYWPDNTNQPLKLgGRFEVSLLKQTN--YDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT--
. |.| . | |..||..|||......|.  |.| | ||. .   .|....| . |.....|.| .. |. . .||||||| || ....|. ..|.     
Ivmltelvelgrekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

-SQAPVVVHCSAGIGRTGALIAVDVALGLME---RDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
 |. ||.||||||.||.|..||.|..| ..|   . . .|| .... ||||| |..|| .||.|.| | || ||.
psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_Ptp69D_pd Subfamily Ptp69D 27-289 3e-65 215.3 In-house 20-285 (307) alignment 
Range on Protein: 27-289
Range on HMM: 20-285/307.0
LDSGMpEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLS---GSSGEDYINANHIRVLvdDDTYHYIATQGPLPNTTKDFWQMIWEQGV
 | |. ..|.. | . .    .  .... |. |||| .. ... |||.|.   |.   |||||..|.    ... ..|| |.|. .| .|||.||.|| |
tdfgl.akeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgy..kekkkfiaaqdPveatigDfWRmiaeqev

EVVAMVTLDKEGGKVKCHRYWPDNtnQPLKLGgRFEVSLLKQTNYDSFVQRDIAVKHLQ-----SGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRS
... |..  .|  . ||..|||..  .  . |    | | .. . . ...|.. | . .       .| ..   ..  |.|  ||...  .....  .|.
tlivmlsnlteknrkkcakYWpie..devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre

LA-TSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
|  ....|.||||||| ||.| ..|.|. |  .. ..  || .|..|||.||. ..|  .||.|.|.| |. 
lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 27-289 6.2e-47 155.1 In-house 11-276 (307) alignment 
Range on Protein: 27-289
Range on HMM: 11-276/307.0
LDSGMP--EEEFKDLREIKPtDGCDSGKNQANTDKNRYRNVLPYEATRVRLSG-SSGEDYINANHIRVLVDDdtYHYIATQGPLPNTTKDFWQMIWEQGV
|| |.    .||. | . .| .|      .||||||||..|   . .|. .       ||| ||.. . ..    ..|..|||| ||  .|| |. .. |
ldkgvqalvdefrvlakktp.egvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp..kkficaqgplentqysfwamaiqekv

EVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLGGRFEVSLLKQTN-----YDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVaymRS
| | |.    | .|.||..||| .  | |  | . .   ...        |  .    ..|   ..||  | ||.. .|||.|||.  .  . ..    .
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainll...ea

LATSQAPVVVHCSAGIGRTGALIAVDVALG-LMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
    . |||||||||.||.|...|. .    ...     |... ...||.||.  |||. ||.. ..  || 
vrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
0043336 (Phosphotyrosine protein) phosphatases II 28-289 1e-82 273.0 In-house 18-276 (278) alignment 
Range on Protein: 28-289
Range on HMM: 18-276/278.0
DSGMPEEEFKDLREIKPtDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG---EDYINANHIRVlvDDDTYHYIATQGPLPNTTKDFWQMIWEQGVE
.  . ..||..|...|. | .. .. ..| |||||...|||. .||.||  .|    |||||... .   . . ..||||||||.|..|||.|.||.||.
lktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdg..ynvprkfiatqgPlpetvedFwrmvwelgvt

VVAMVTLDKEGGKVKCHRYWPdntNQPLKLgGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT-SQ
.. |.| ..| |.|||..|||   ...|.  |.| | |||.. .| ...|.. |..|..|.| .. |. ...||||||| |.  ...|. ..|.    |.
tivmLtelvelgrvkcaqYwp...ggslty.gdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsn

APVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
 ||.||||||.||||..||....| ..|. . .|. .....||||| |..|| .||.|.|.| || 
gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPRG_pd Subfamily PTPRG 28-292 1.3e-64 213.4 In-house 18-289 (563) alignment 
Range on Protein: 28-292
Range on HMM: 18-289/563.0
DSGMpEEEFKDLREIKPTD--GCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG---E-DYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQ
| |. .|||..| .   ..   ... ... |  |||| |...|. .||.||. .|   . ||||||.|      .   .|||||||..|..|||.|||||
digf.seefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqksk..afiatqgplkdtfddFWrmiWeq

GVEVVAMVTLDKEGGKVKCHRYWPDntNQPLKLgGRFEVSLLKQTNYDSFVQRDIAVKH--LQSGKS----IEIAHLNFVKWPDHGVPRSPVEMVQFVAY
 |... |.|  .| |. ||..|||   ...... | ..| | ..    .  .| . .|.  |. .|.     .. . .. |||||||| ...  ..||  
nvaiivmitnlvergrrkcdvYWPk..desety.galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkk

MRSLATS-QAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
      .   |.|||||||.|||| .|..|  |  .....  .. .... .| ||. ..||..|||| ..| ||...|
ssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 28-289 3.2e-40 132.7 In-house 21-286 (305) alignment 
Range on Protein: 28-289
Range on HMM: 21-286/305.0
DSGMpEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSGEDYINANHIRVlvDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVA
  |.  .||. .. ..  .   . |.  ...||||..|   .  ||.| |.   .|| ||..      ..  .| || || .|  ||| | ... || . 
pagl.raefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvst..ptnpkrfictqaplektcadfwymclqdkveaif

MVTLDKEGGKVKCHRYWPDNTNQPLKL-------GGRFEVSLLK--QTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRs
|.   .| |  ||. |.. . .. |..         .|| |     ... .. |.. . |     .|.  ..|  .. ||| ||| . . ......  | 
mlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.

laTSQAPVVVHCSAGIGRTGALIAVDVALG-LMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
  .|. |.||||||||||||... ..  |  |.. ..  | .. .. .||||.  ||| .||.| ..  |. 
..pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
0051299 (Phosphotyrosine protein) phosphatases II 29-290 2.2e-88 291.8 In-house 22-286 (288) alignment 
Range on Protein: 29-290
Range on HMM: 22-286/288.0
SGMPEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG---EDYINANHIRVlvDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEV
  . .|||..|....|.  . ... ..| .||||...|||. .||.||  .|    |||||..|..   . . ..||||||||||..|||.|.|||.|.|
ltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg..ynlkrkfIatqgPlpntvedFWrmvweqnvrv

VAMVTLDKEGGKVKCHRYWPDntNQPLKLGGrFEVSLLKQTNYDSFVQRDIAVKHL----QSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLA-
. |.|   | |..||..|||.  ...|..|  . | ||. . .|....| . |..|    ..|.|... |. . .||||||| || ....|. ..|.   
IvmltklvelgrekcaqYwpl..ggsltygd.itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

TSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
 .. |||||||||.||||..||.|..| ..|. . .|. .... ||||| ||.|| .||.|.|.| || |
sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 29-291 1.9e-68 225.9 In-house 21-284 (305) alignment 
Range on Protein: 29-291
Range on HMM: 21-284/305.0
SGMPEEEFKDLREIkpTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSGED---YINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQGVEV
.   |...| | |    . .| ||..||. |||.... ...  |..|. .. .|   ||||...      .  .||..||||.|| .|||..|.|  |..
dkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk..kyivaqgPlkntvadfWrliveekvst

VAMVTLDKEGGKVKCHRYWPDNTNQPLKLgGRFEVSLLKQTNYDSFVQRDIAVKH-LQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQ-
. |.|  .|||| ||..|||...... .. |.|.| |  ....  ...|.. .    .. .|  . .... .|||||||...  .....  ..    .. 
ivmltklveggkdkCrqYWpesktekkef.gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

-APVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
  |..||||||.||||. ||||.||  .....  |. . .. ||..| .|.||.||| |.. |  | ..
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 29-291 3.5e-44 146.0 In-house 19-280 (439) alignment 
Range on Protein: 29-291
Range on HMM: 19-280/439.0
SGMPEEEFKDLREIKPTDGCDSGKN--QANTDKNRYRNVLPYEATRVRL---SGSSGEDYINANHIRVLVDDDTyhYIATQGPLPNTTKDFWQMIWEQGV
  . .|.|. .  ..|   |..     . .  ||||..| ... ||| |    |     |||||.|.   ||.   |||||||  .||.|||....|. .
qeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddkl..yiatqgpkkettddfwrlviekkt

EVVAMVTLDkeggkVKCHRYWPDNTNQplkLGGRFEVSLLKQTNYDSFVQRDIAV--KHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT
  . |.|       |. ..||| ...      |   |   .. .   .| | . |  .. .. |   . .. .. |||. ||     ...|.  . |   
vtivmltnl.....vesykywpsdaev...cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand

S--QAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
.    |||||||||.||||..||.|.||  .  ..  ||.  .. ||.||. |.|.  ||.| |.| || ..
keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 30-290 2.6e-46 152.8 In-house 20-236 (392) alignment 
Range on Protein: 30-290
Range on HMM: 20-236/392.0
GMPEEEFKDLREIKpTDGCDSGKNQANTDKNRYRNVLPYEATRVRL---SGSSGEDYINANHIRVLVDDDTyhYIATQGPLPNTTKDFWQMIWEQGVEVV
 .  |||.|| . .      ..... |  ||||.|.|||...||.|     .. .||.|| .|. .  . .  |||.||| . . .|||.|.... |  .
alffeefhdlpgpd.iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdneka..yiasqgpnaaslddfwrmvfqenvtti

AMVTLDKEGGkvkchrywpdntnqplklggrfevsllkqtnydsfvqrdiavkhlQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQA-P
||||  |||                                              .  .   .|   |..|||..||.    ...|.  ...   . . |
amvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythp

VVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
...|||||.|||| .|..|  .   .. .  |. . . ..|..|  |.|||.|| | | | || |
liihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_PTPRA_pd Subfamily PTPRA 31-289 3.6e-65 215.0 In-house 33-294 (330) alignment 
Range on Protein: 31-289
Range on HMM: 33-294/330.0
MPEEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG---EDYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQGVEVVA
.  |||. |   .    ..  ... | .|||. |.|||. .|| ||  .|    ||||| .|    . |  ..||.|||. .| .|||.|||||    . 
lfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd..kfiaaqGPkeetvedfwrmiweqksativ

MVTLDKEGGKVKCHRYWPDNTNqplKLGGRFEVSLLKQTNYDSFVQRDIAVKHL----QSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQ
|.|  ||  . ||..||||.        |   |.. ..|   ..  |.. |..|    .  ||  .. . |  ||| |||  |. |..... ...|   .
mltelkerkeekcaqywPdeGl...vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs

-APVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
  |.|||||||.||||..|..|  |  .. ..  |. .... || ||  |.||. || |.||. || 
agpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
0045450 (Phosphotyrosine protein) phosphatases II 32-290 3e-85 281.9 In-house 29-304 (307) alignment 
Range on Protein: 32-290
Range on HMM: 29-304/307.0
PEEEFKDLREIKP--TDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG----EDYINANHIRV------LVDDDTYHYIATQGPLPNTTKDFWQMIW
 ..||..|.....   . ..... ..| |||||...|||. |||.||  .|     |||||...||       . | . ..||||||||.| .|||.|.|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlw

EQGVEVVAMVTLDKEGGKVKCHRYWPDNtNQPLKLGGrFEVSLLKQTNYDSFVQRDIAVKHL-QSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRS
||||.|. |.| ..| |..||..||||. ...|  |  | | ||. . .|... | . |..| ..|.|... |. . .||||||| |. |...|. ..|.
eqgvtvivmltelvelgrekcaqywPde.geeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

LAT---SQAPVVVHCSAGIGRTGALIAVDVALGLMERDKP---FDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
      .. ||.||||||.||||..|| ...| ..|...    .|. .... ||||| |..|. .||.|.|.| || |
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 32-292 1.8e-74 245.7 In-house 25-285 (319) alignment 
Range on Protein: 32-292
Range on HMM: 25-285/319.0
PEEEFKDLREIKPTdGCDSGKNQANTDKNRYRNVLPYEATRVRLS---GSSGEDYINANHIRVLVDddTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAM
 |.|||.|.| ...   || ... | .||||.|.|.|. ||| ||   |. | |||||..|    .     .||||.|| ||..|||.|.||... .| |
lekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqe..rekfiatqaPlentiedfWrmvWeeessivvm

VTLDKEGGKVKCHRYWPDNTnqpLKLGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGK-SIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT--SQAP
.| ..| .|||...|||...    . .||. | |... . . .. |.. .....|   . |. |  . .||||.||..   .....  .|      .. |
ltklveklkvklkkywpeen...feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgP

VVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
.|||||||.||||. |..|..|  ....   |. .|.. || ||. |.|...||.|.|.| ||....
ivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 32-291 2.8e-48 159.2 In-house 17-294 (301) alignment 
Range on Protein: 32-291
Range on HMM: 17-294/301.0
PEEEFKDLREIKPtDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG-----EDYINANHIRVLVDDdtYHYIATQGPLPNTTKDFWQMIWEQGVEVV
 ||..|.|.| .. . |. | ...|.  ||..|. .|.  |. |.  .      ..||||..|    .    ..||.|||. .| .|||..||.. .  .
feeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek..kkfiaaqgpmkktlvdfWrliwqekpvsi

AMVTLDKEGGKVKCHRYWPDNTNQPLKLgGRFEVSLLKQTNYDSFVQRDIAVKHLQ--------------SG-KSIEIAHLNFVKWPDHGVPRSPVEMVQ
 |||  ||| | ||..|||. ...  .  | |.| | ....| .|| |...||  .              |  .| ..  |. ..||..|| | |  ..|
vmvtnlkegtkskceqywpnseaeseef.gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

FVA--YMRSLATSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
 .    .|    . .|||||||....|.|  ..|...|    ..   |. | .. .| .. |...| .||.. |..  . |.
viddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_PTPRD_pd Subfamily PTPRD 33-293 1.3e-90 299.7 In-house 26-284 (564) alignment 
Range on Protein: 33-293
Range on HMM: 26-284/564.0
EEEFKDLREIkPTDGCDSGKNQANTDKNRYRNVLPYEATRVRL---SGSSGEDYINANHIRVLVddDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMV
|||.|...|  ..  ... ...||  |||| |...|...||.|    | .| |||||..|         .||||||||..|..|||.|.||| .... |.
eeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVml

TLDKEGGKVKCHRYWPDNtNqPLKLgGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQA-PVVV
|  .| ||||||.|||.. . . .  |...|.| .....  .. |.. .|. .| .| |. . .|..||||||| |. ......  .|.|....| |.||
tkleEkgkvkchkYWPek.g.tety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivV

HCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSL
|||||.||||. |..|. |  .. .|  || |... ||.||. |.||..||||...| || |.. 
hCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
DSPc_SM00195 33-290 1.2e-86 285.7 In-house 3-262 (263) alignment 
Range on Protein: 33-290
Range on HMM: 3-262/263.0
EEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSS---GEDYINANHIRVLvdDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMV
.|||..|.| .... ..... ..|..||||.|.|||. |||.|. .    |.||||||.|..   . . .|||||||||.| .|||.|.||..|....|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TLDKEGGKVKCHRYWPDNTNQPLKLGgRFEVSLLKQTNYD-SFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT-SQAPVV
| ..| || ||.||||.. ... . | ...| | ...... ....|.. ... .  .. .. .... .||||||| |. ...... ....    |..|.|
teeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
||||||.||||.....|..|  .|..| .|| .... ||.|| ||.||..||.|.|.| ||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 33-290 1.2e-86 285.7 In-house 3-262 (263) alignment 
Range on Protein: 33-290
Range on HMM: 3-262/263.0
EEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSS---GEDYINANHIRVLvdDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMV
.|||..|.| .... ..... ..|..||||.|.|||. |||.|. .    |.||||||.|..   . . .|||||||||.| .|||.|.||..|....|.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TLDKEGGKVKCHRYWPDNTNQPLKLGgRFEVSLLKQTNYD-SFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT-SQAPVV
| ..| || ||.||||.. ... . | ...| | ...... ....|.. ... .  .. .. .... .||||||| |. ...... ....    |..|.|
teeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
||||||.||||.....|..|  .|..| .|| .... ||.|| ||.||..||.|.|.| ||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRB_pd Subfamily PTPRB 33-292 1.2e-84 278.8 In-house 28-287 (293) alignment 
Range on Protein: 33-292
Range on HMM: 28-287/293.0
EEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRL---SGSSGEDYINANHIRVLVddDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMV
 ||...|.... .  ... ....|..||||.|.|||...||.|   ...||.||||||.|. .    . ..||||||||.|..|||.|.||. .... |.
seeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn..sprefiatqGPlpetvddfWrmvwekkssiivml

TLDKEGGKVKCHRYWPDNTNqPLkLGGRFEVSLLKQTNYDSFVQRDIAVKHlqSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLA---TSQAPV
|   |.|||||..|||.... |  | |  .|.|....... .| |......  . .. .. ...|. ||||||| ..  ...||  .|. .   .|..|.
tqlvekgkvkCeeYWPadee.pv.lyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPi

VVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
|||||||.||||..||.|  |  .|..   ||  .. .|||.|. ..||..|||| ... |..|..
vvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 33-293 1.5e-79 262.4 In-house 23-283 (318) alignment 
Range on Protein: 33-293
Range on HMM: 23-283/318.0
EEEFKDL-REIKPTDGCDSgKNQANTDKNRYRNVLPYEATRVRLS---GSSGEDYINANHIRVLVDDDTyhYIATQGPLPNTTKDFWQMIWEQGVEVVAM
.||.. | |. . .   .|  ...|  |||| |.|.|. |||.|.   |. | ||||||.|     . .  |||.|.|||.| .|||.|.|||.  |. |
seeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkka..yiaaqaPlpetieDfWrmvWeqnsavivm

VTLDKEGGKVKCHRYWPDNTNQPLklgGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLA--TSQAPV
.|  .| ||.|.|||||..  . .   |.  | | ........| | . |.. .. .| ..   .. .|||.||| |.......|   ..    ... |.
ltqeeergkakvhryWPskgsrsy...gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

VVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSL
|||||||.||||  ||||. |  .. ..  |. ||.. |||||. |.||.|||.|.|.. || |.| 
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 33-290 2.6e-77 254.7 In-house 24-279 (288) alignment 
Range on Protein: 33-290
Range on HMM: 24-279/288.0
EEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSG---SSGEDYINANHIRVlvDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMV
.||.. | ... |.  . |..  | .||||||.|||. .||.| .    .|.|||||..| .  .. . .||||||||..| .|||....|. .. ..|.
seeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidg..ekkkkkyiatqgPladtvndfWelvyenktstivml

TLDKEGGKVKCHRYWPDNTNQplKLGGRFEVSLLKQTNYDSFVQRDIAVKhlQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQ-APVVV
|   |||| ||..||||. ..  |. | ..| |... . ..||.| . ..  .... .|| ....  |||||||.|  ......  .    ...  |..|
telveggktkCeeYWPdadkp..knyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiiv

HCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
|||||.||||  ||.| ..  .|...  |.  |.  ||.||. ..||. ||.|.|.. |.. 
hCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN6_pd Subfamily PTPN6 33-291 5.7e-77 253.7 In-house 29-298 (306) alignment 
Range on Protein: 33-291
Range on HMM: 29-298/306.0
EEEFKDLRE--IKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRL--SGSSGEDYINANHIRVLVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAM
||||..|..   | .   . |. . |. ||||.|.||.. ||| |  .. .|.|||||| |.  | . . .|||||| |..| .|||.|.|..  .|. |
eeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm

VTLDKEGGKVKCHRYWPDNTNQPLklGGRFEVSLLKQTNYDSFVQRDIAVKH-LQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATS-----
.| . | || || |||||.....    |. .|. ..... .... |.. |..  ..... |. ...| .|||||||..|  ...|.  ... . .     
ttkevErgkekCarYWPdeeekee..yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeae

QAPVVVHCSAGIGRTGALIAVDVALGLMER---DKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
. |.||||||||||||..| .|. | |.|.   | ..||..... .||||.|..||..|| | |||  . ..
agpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 33-293 1.5e-72 239.3 In-house 30-293 (298) alignment 
Range on Protein: 33-293
Range on HMM: 30-293/298.0
EEEFKDLREIKP---TDGCDSGKNQANTDKNRYRNVLPYEATRVRLSG---SSGEDYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQGVEVV
..||. |....    ..  . .....| .|||| ...... .||.|.        ||||| ..    . .   .||||.||..|..|||.|..|. ....
alefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigti

AMVTLDKEGGKVKCHRYWPDNTNQPLklgGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQ--A
 |.|  .| .|.|.|.||||. ..     |...||||.. ..  ...| ..|.. .. |. |. .|.|..|||.|||.    ...... .|   .    .
VmltnleeldktkyhkywPdegkety...geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnk

PVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSL
||.|.||||.||.|. ||.|  |  .....  |. |... ||..| |..||..||.|.|.| ||.|.| 
pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 33-291 4.1e-63 208.1 In-house 22-278 (315) alignment 
Range on Protein: 33-291
Range on HMM: 22-278/315.0
EEEFKDLREIKPTdGCDSGKNQANTDKNRYRNVLPYEATRVRL---SGSSGEDYINANHIRVLVDDDTyhYIATQGPLPNTTKDFWQMIWEQGVEVVAMV
 |||.|| . ..     ..... |  ||||.|.||.. .||.|     |  .||||| .|. . || .  |||.||||. . .|||.|.... |  ..||
seefhdlpdPdiy.rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddka..yiasqgPlkasvddfwrmvlqekvttivmv

TLDKEGGKVKCHRYWPDNTNQPLKLGgRFEVSLLKQTNYDSFVQRDIAVKhlQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSL-ATSQAPVVV
|  .|| |.|| .||||.  .  ..|  ..|.||.       |.| . ..  .| .|  ..  .| .|||.||..    .....  ...   . . ...|
tkkqegdkikcrqywPdrkadsvefG.sikvellsleadtdgvarklvtr..kseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllv

HCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
|||||.|||| .|..|  .  ..| .  |. .... ||..|  ..||...| | | | || |.
hcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 33-291 2.6e-61 202.3 In-house 21-277 (515) alignment 
Range on Protein: 33-291
Range on HMM: 21-277/515.0
EEEFKDLR--EIKPTDgcdSGKNQANTDKNRYRNVLPYEATRVRL---SGSSGEDYINANHIRVLVDDDTyhYIATQGPLPNTTKDFWQMIWEQGVEVVA
 |||.||   .| |       ... |  ||||.|.|||. .||.|     .  .||.|| .|. .  | .  |||.|||.. ...|||...... |  .|
seefhdlpgpniypqt...vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndka..yiasqgPnkasvddfWrlvlqenvttia

MVTLDKEGGKVKCHRYWPDNTNQPLKLGgRFEVSLLKQTNYDSFVQRDIAVkhLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLA-TSQAPV
|||  ||| |.|| .||||   . .|.|  ..|.|.        ..| . |  |.. .|  ..  .| .|||.|||.    .....  ...     . |.
mvtklkegdkikcgkyWPdkpgdsvkfG.sikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpl

VVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
..|||||.|||| .|..|  .  ..  .  |. .... .|..|  ..||..|| | | | || |.
iihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 33-293 2.5e-57 188.9 In-house 23-286 (290) alignment 
Range on Protein: 33-293
Range on HMM: 23-286/290.0
EEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSGE-----DYINANHIRVLvdDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVA
...|| |   .       |  . |  .||..|...|.  |. |   ||.     .|||| .|      . ..|||||||..|| .|||..||.. | .. 
rnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy..kekkqyiatqgpvsntlvdFWkliwqekvtiiv

MVTLDKEGGKVKCHRYWPDNTNQPlklGGRFEVSLLKQTNYDSFVQRDIAVKHLQS-GKSIEIAHLNFVKWPDHG-VPRSPVEMVQFVAYMR-SLATSQA
|.|  .| |||||. ||||. ..     | |.. ||..........| . ||. .| |.. .. ....  |...| |.     ....   ..    . . 
mltniieegkvkCqqYWpdsdtka...ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgnt

PVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSL
..|||||...||.. ..|.....  .. .   |. | .. .| |. |..||..|| . ..  |. |.|.
sivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 33-288 1.5e-39 130.4 In-house 14-267 (281) alignment 
Range on Protein: 33-288
Range on HMM: 14-267/281.0
EEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLSG----SSGEDYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQGVEVVAM
..|| .|    |.| |   ..  |  |||| |.   . .||.|          ||| ||.||  .      || ||||  .|  |||.|||..    . |
kqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkr..gyiltqgpkketradfwrmiwqenttaivm

VTLDKEGGKVKCHRYWPDNTNQPLKLgGRFEVSLLKQTNYDSFVQRDIAVKHlqSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRslaTSQAPVVV
.    |  . ||  |.| |.   |..  .. ||    |   |.|   . . .   |..  |.|  . .|||  || |   |.. .  .|   .  .| |.
lcqfletnrekcaeyfprnahcclqf.dklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrkir...arstppvi

HCSAGIGRTGALIAVDVALGLMERD-KPFDINQTIRDLRE-QRQGMIQTKDQYIFCYKACLE
|||||.||.|.|.||..||  .       ||.| .  ||   |   .|| .||.. .|  |.
hcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 33-287 3.9e-38 126.0 In-house 9-256 (267) alignment 
Range on Protein: 33-287
Range on HMM: 9-256/267.0
EEEFKDLREIKPTDG-CDSGKNQANTDKNRYRNVLPYEATRVRLSGSSgEDYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTL
|.||. ...| .|   .     . | ..||. ..|||. ||| |. .  |.|||| ..         ..|.||.|| ||  ||...| .|.| |. ..| 
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke.eeyinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivlltk

DKEGgkvKCHRYWPDNTNQPLKLGG-RFEVSLLKQTNYDSFVQRDIAVKHlQSGKsiEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQAPVVVHC
  ..   . ...|| .  |  |      | || |. |    .  .. .|  .| .  ...   . ||      .  .. .  .     |   . |.||.|
vftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn.esah..nvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvac

SAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACL
|.|.||.|... .|  |  . ..   || . .| .|.|| |...||..||....   
sdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella
subfamily_ptpA1_pd Subfamily ptpA1 33-243 2.2e-35 117.2 In-house 24-249 (418) alignment 
Range on Protein: 33-243
Range on HMM: 24-249/418.0
EEEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRLS---GSSGEDYINANHIRVLVdddTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMV
.|||. | |         | .. || |||| |.|| . |||.|       | ||||||.|         ..|.||||||||  |||.|.||. . .. |.
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay...pkqfictqgplpntiadfwrmvwenrcriivml

TLDKEGGKVKCHRYWPDNT--NQPLKLG------GRFEVSLLK--QTNYDSFVQRDIAVKhlQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRS-
. . |  ..|| ||||..   .|    |      | . | |..  |      . |.| .     |.. .|.. ..  |||| .|     . |..  .   
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirlt..fegetrditqyqyegwpdhnipdhtqpfrqllhsitnr

----L--ATSQAPVVVHCSAGIGRTGALIAV
    .  .  . |..||||||.||||.. . 
qnqiipssdrnvpiivhcsagvgrtgtfcta
0046845 (Phosphotyrosine protein) phosphatases II 34-292 3.9e-89 294.1 In-house 4-276 (284) alignment 
Range on Protein: 34-292
Range on HMM: 4-276/284.0
EEFKDLREIKPTD--GCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG----EDYINANHIRVLVD---DDTYHYIATQGPLPNTTKDFWQMIWEQGVE
|||. |. ....    .. .. ..| .||||...|||. .||.|.  .|     |||||.....      . . ..||||||||||..|||.|.|||.|.
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

VVAMVTLDKEGGKVKCHRYWPDNtNQPLKLGGrFEVSLLKQTNYDSFVQRDIAVKHLQ-SGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATS-
|. |.|   | |..||..|||.. ...|..|. | | ||. ...|....| . ...|. .|.|... |. . .||||||| ||  ...|. ..|.| .. 
vIVmltelvengrekcaqYwple.gevltygd.ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

--QAPVVVHCSAGIGRTGALIAVDVALGLMERDK---PFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
  . |.|||||||.||||..||.|..| ..|...    .|. .... ||||| ||.|| .||.|.|.|.|| ||.
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0045098 (Phosphotyrosine protein) phosphatases II 34-291 3.4e-79 261.4 In-house 11-273 (278) alignment 
Range on Protein: 34-291
Range on HMM: 11-273/278.0
EEFKDLREIKPTDGCDSGKNQANTDKNRYRNVLPYEATRVRlsgssgeDYINANHIRVLvdddTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDK
 ||  |.   . . .  .    | |||||...|||. .||.       |||||..|..     . ..||||||||.|. |||.|.||.|..|. |.|  .
lefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

EGGKVKCHRYWPDntNQPLKLgGRFEVSLLKQTNYDSFVQRDIAVKHL----QSGKSIEIAHLNFVKWPDHGVPRSP--VEMVQFVAYMRSLAT------
|.|..||..|||.  ...|   |.|.| ||. ...| .. |.. | .|    ....| .. ||... ||||||| .|    . ... ..|.         
elgrekcaqywpe..ggslty.gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasll

--------SQAPVVVHCSAGIGRTGALIAVDVALGLMerDKPFDINQTIRDLREQRQG-MIQTKDQYIFCYKACLEVLK
        |. ||.||||||.||||.|.|..  | |.  .. .|. .... ||.|| | ..|...||.|.|.. ||.|.
lsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN23_pd Subfamily PTPN23 34-294 2.1e-70 231.8 In-house 19-284 (288) alignment 
Range on Protein: 34-294
Range on HMM: 19-284/288.0
EEFKDLREIKPTDGCDS--GKNQANTDKNRYRNVLPYEATRVRLSgSSGEDYINANHIRVLVDdDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTL
..||.|.. .  .  .      . ...|||.|..|||. .|| |  .| .||||| ... |.   . ..||||.||..|  |||.|..|| ..|. |.. 
kkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlsp.gcPdfiatqaPlqstlnDFWlmvyeqkssviVmlls

DKEGGKVKCHRYWPDNTNQPLKLGGrFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRS-----LATSQAPV
 .| || |..|||| ..... | |  ..|.| .... . .|.|.. ...|.. .  .. ||.. .||..||| || ...||.  ..|        |..|.
keelgkpkvdrYwPedkgetvkfgd.lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPl

VVHCSAGIGRTGALIAVDVA-LGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSLA
|||||||.||||..  |  |   | ...   || | .. |||||. |.|.|.|. |.|.| ||  .   
vvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_CG42327_pd Subfamily CG42327 34-213 1e-27 91.6 In-house 9-187 (319) alignment 
Range on Protein: 34-213
Range on HMM: 9-187/319.0
EEFKDLREIKPT-DgcdsGKNQANTDKNRYRNVLPYEATRVRLSGS---SGEDYINANHIRVLvDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMV
|||.||  .    |        .  ||.|. ||.|   ||| |        . |..|...|   ||   .|||.| .| ... |||...|||   |.  .
eefrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGy.ddapnsyiaaqvsledsssdfwrtvweqqsrvivql

TLDKEGGKVKCHRYWPDN-TNQPLKLGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFvKWPDHGVPRSPVEMVQFV
|   | |  .| .|.| . | .  .| | . |.| ..   | ..   . .|...  .| |..|  . ||.. .|| ..  ..  .
tdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 39-218 2.6e-42 139.7 In-house 17-195 (297) alignment 
Range on Protein: 39-218
Range on HMM: 17-195/297.0
LREIKPTDgCDSGKNQANTDKNRYRNVLPYEATRVRLSG-SSGEDYINANHIRVLVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGK
|.| .. .   | | ..   |||||..| .. |||.| .  ...|||||...    ..  ..|| .|||| .| .|||....||.| |..||.  .|.|.
ldearges.fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

VKCHRYWPDNTNQPLKLgGRFEVSLLKQTN--YDSFVQRDIAVKHLqsGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRS
 ||  |||.  .. ||  | . |  | .|   .|  .  .. . .    .|  . | .|. |||||||    ..|.| | . |
dkcapywpsvvqerlka.gdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcs
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 39-105 2e-10 34.7 In-house 29-95 (95) alignment 
Range on Protein: 39-105
Range on HMM: 29-95/95.0
LREIKPTDG--CDSGKNQANTDKNRYRNVLPYEATRVRLSGSSGEDYINANHIRVLVDDDTyhYIATQG
.. |  | |     |  .||  |||. |..||.|||| |.     |||||  .      .   |||.||
fksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarknc..yiaaqg
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 44-289 9.7e-51 167.1 In-house 42-282 (290) alignment 
Range on Protein: 44-289
Range on HMM: 42-282/290.0
PTDGCDSGKNQANT--DKNRYRNVLPYEATRVRLSGSSGEDYINANHIRVLvdddTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCH
|..  .    ..||   ||||..|   . ||| |.     ||. ||... |       .| |||.| .|. |.|.|. ...| .. |.    | || ||.
pvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGl....kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakce

RYWPDNTNQPLKLGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFvayMRSLATSQAPVVVHCSAGIGRTGALI
.|.|..  . | .|    .  ..... .  ... ..|.. .|||.  . ||. . |||. |. | . ...    .|.| .   ||||||||||||||...
qyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrt...lrilrkasGpvvvhcsaGiGrtGtfv

AVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
|..|.| ..   | .|. ...| ||. | . .|   ||.   .. |..
aievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_eak_pd Subfamily eak 44-215 1.4e-12 41.7 In-house 40-203 (332) alignment 
Range on Protein: 44-215
Range on HMM: 40-203/332.0
PTDGCDSGKNQANTDKNrYRNVLPYEATRVRLSGSS--GEDYINANHIRvlVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCH
.      ..   . ..|   ...||.   |||. |    . ||||  .     .   .|| |  .  .    ||||. ||    . ..  | | .  |  
rllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslae..fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksd

RYWPDNTNQPLKLGgRFEVSLLKQTNYDSFVQRDIAVKHlqSGKSIEIAHLNFVKWPDHGVPRspveMVQFVAY
.|.||.| . || |  ..|   .  . . .  | . ..     .. .. | ..  | .  .|.    . .|.|.
kyfpdktreelkfG.ildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpk....yedflal
subfamily_PTPRK_pd Subfamily PTPRK 45-289 2.9e-66 218.5 In-house 32-276 (314) alignment 
Range on Protein: 45-289
Range on HMM: 32-276/314.0
TDGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSGE---DYINANHIrvlvD--DDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVK
 .| |. |.. | .|||. ..|.|. .||.|    |.   |||||. |    |    . ..|.|||||..|.||||.......   . |.|  .| |.||
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali....dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvk

CHRYWPDNTNQplklGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGK--SIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT-SQAPVVVHCSAGIGR
| .|||..|..     | ..| |.. .    .|.|  .|..|. |.    |. ...|..||||.|| |   ....|. . .    .. ..||||||| ||
ClkyWPedtev....ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGr

TGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
||. ||.|. | ..||..  |. .....||...  |..|..||.|.| . || 
tGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 46-288 3.4e-54 178.6 In-house 23-264 (283) alignment 
Range on Protein: 46-288
Range on HMM: 23-264/283.0
DGCDSGKNQANTDKNRYRNVLPYEATRVRLSGSSGeDYINANHIRVLVDD-DTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYW
  .|   .. |  |||.....|..  ||.|   |  ||||| .| |  .. .   ||..|.|| .| .|||.|.... .  . |.|  .|. ..|| .||
ldadiasadenkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

PDNTNQPLklgGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKS-IEIAHLNFVKWPDHGvPRSPVE-MVQFVaYMRSLAT--SQAPVVVHCSAGIGRTGAL
| .  .     | | |.| |.|  .||... . ...  | || . .||  .. | . | . .... .|.|   ..|| |   ..|.|||||.|||||...
PkrGsedy...GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfn.kvislqteskkgPivvhCstgiGrtavf

IAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLE
||. ...  .  .   |. .... .|||| ...||.||| . ... ||
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_CG7180_pd Subfamily CG7180 46-289 6.2e-46 151.4 In-house 32-289 (296) alignment 
Range on Protein: 46-289
Range on HMM: 32-289/296.0
DGCDSGKNQANTDKNRYRNVLPYEATRVR---LSGSSGEDYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKvKCHR
. |  | .. | .|||. .|.||. .||    | | . .||||| ..  .. .    || |..|  .| ..||......... | ..|   .  | ... 
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkk..eyivteapkketvdefWrlvydeeisavvvLtktfdfak.myps

YWPDNTnqPLKLgGRFEVSLLKQTNYDSFVQRDIAVKHL-------QSGKSIE---IAHLNFVKWPD-HGVPRSPVEMVQFVAYMRSL---A---TSQAP
||| ..    .  | ..| .... .|  ...| . ...        . . ..|   . .... .|.  . || |   .....  .|..   .     ..|
ywpnks..keqy.geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP

VVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
|||..| | .|.|. .|.|..| |.|... .|. . .. ||..|.........| ..|   || 
vvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_PTPRN_pd Subfamily PTPRN 47-290 2.9e-56 185.3 In-house 47-292 (297) alignment 
Range on Protein: 47-290
Range on HMM: 47-292/297.0
GCDSGKNQANTDKNRYRNVLPYEATRVRLSGS---SGEDYINANHIrVLVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRY
 .. .|.. | .|||...||||. .||.|. .   . .|||||  | .  |  .  ||||||||..|  |||||.||||| |. ..|  .| |  .|.||
tkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasai.ldhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

WPDNTNQplkLGGRFEVSLLKQT-NYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYM-RSLATSQAPVVVHCSAGIGRTGALI
|||. ..   . . .|| |. .    | .. | . .| ||. ..  .. . |. ||..||| |.  ...|   . .|     .|.|||||.| ||||. |
wpdeGse...vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyi

AVDVALGLMERD-KPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
..|. |  . .  |  ||  |.  ||.||.|...||||. |...|  | .
lidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
0040439 (Phosphotyrosine protein) phosphatases II 48-290 2.7e-77 255.0 In-house 3-246 (249) alignment 
Range on Protein: 48-290
Range on HMM: 3-246/249.0
CDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG---EDYINANHIRVLVddDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYW
.. .. ..| |||||...|||. .||.||  .|    |||||..| .     . ..||||||||.|..|||.|.||.|..|. |.| ..| |..||..||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyy..ikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PDntNQPLKLgGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT---SQAPVVVHCSAGIGRTGALI
|.  ...|.  |.| | ||. . .|....| . ...|. |.|... |.....||||||| |. ....|. ..|.  .   .. ||.||||||.||||..|
pl..ggsley.gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

AVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
| . .| ..|. . .|. .....||.|| |..|. .||.|.|.| || |
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 48-290 1.2e-75 249.4 In-house 1-243 (245) alignment 
Range on Protein: 48-290
Range on HMM: 1-243/245.0
CDSGKNQANTDKNRYRNVLPYEATRVRLSGSSG---EDYINANHIrvLVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYW
..... ..| |||||...|||. |||.||  .|    |||||...   ... | ..||||||||.|..|||.|.||.|.... |.| . | |.|||..||
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

PDntNQPLKLGGrFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT--SQAPVVVHCSAGIGRTGALIA
|.  ...|. |. | | ||. ...|....| . |..|....| |. |. .. ||||||| ..  ...|. ..|.     |. ||.||||||.||||..||
pl..gesltygd.ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfia

VDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
.. .| ..|. . ... .....||.|| |..|| .||.|.|.| || |
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN1_pd Subfamily PTPN1 48-293 3.5e-68 224.4 In-house 24-274 (290) alignment 
Range on Protein: 48-293
Range on HMM: 24-274/290.0
CDSGKNQANTDKNRYRNVLPYEATRVRLSGSSGeDYINANHIRVlvDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWP-D
. . |...| ..||||.| ||. .|..|  ..  |||||. . .  ..   .|| ||||||||.. ||||.|||    | |.    | ...||..||| .
treaklpenrnlnryrdvspydhsrikleradn.dyinaslvel..eeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

NTNQPLKLG-GRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMR---SLATSQAPVVVHCSAGIGRTGALIA
. .. |.|   ...| |... ... .. | . .. |.. .. || |  ...||| |||.||  ...|.  .|   ||.. . |.|.||||||||.|... 
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

VDVALGLMERDKP---FDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSL
||  | |.|. .     ||.... .||..| |.|||.||  | | | ||  | .
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 48-289 1.4e-38 127.5 In-house 27-269 (285) alignment 
Range on Protein: 48-289
Range on HMM: 27-269/285.0
CDSGKNQANTDKNRYRNVLPYEATRVRLSGsSGEDYINANHIRVLVDdDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDN
|     .|| | ||| .|   | ||| |      ||| |. .|.    |   ||.||||||.|  |||.||... .  | |.    |||  ||  |.|..
ctytayeanpdlnryadvrcieetrvvlkn.hdrdyihaswmrmpgk.dqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

TNQPLKLGgRFEVSLL--KQTNYDSFVQRDIAVKHLQS--GKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQAPVVVHCSAGIGRTGALIAV
  . .|.| ..|..|   |.      .   ..|   .    . . . |..   |||.  |     |...  ... .   . |..||||||.||| ... .
lgevvkfg.kyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgi

DVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
| |   .  .   .. . .|..|  |   .|.. |..| |   .| 
dyatirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_PTPN12_pd Subfamily PTPN12 49-292 1.8e-75 248.5 In-house 33-279 (290) alignment 
Range on Protein: 49-292
Range on HMM: 33-279/290.0
DSGKNQANTDKNRYRNVLPYEATRVRLSGS---SGEDYINANHIRVLvdDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWP
..|... |. ||||...|||. .|| ||      |.||||||.|.    ... .|||.|||||.| .|||.||||. ||.| |.    | || ||.||||
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgv..egkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DNTNQPLKLgGRFEVSLLKQTNYD-SFVQRDIAVKHLqsGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQ-APVVVHCSAGIGRTGALIAV
......|.  | |||.| .. . |  |. | ..|..   ..| ..  ... .|||||||.|. ....... .|.| .|. ||.|||||||.||||..||.
eegeeelef.gefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DVALGLMERDKP---FDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
| .  |....|    .|. . ...||.||. ..|||.|| . ||| .|....
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 49-290 8e-53 174.4 In-house 42-279 (315) alignment 
Range on Protein: 49-290
Range on HMM: 42-279/315.0
DSGKNQANTDKNRYRNVLPYEATRVRL---SGSSGEDYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWP
|  |.  | .|||| |...|. .||.|      .. ||.||| |      .  .|||.|||.... ||||....|. .  . |.|   || | |. .|||
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkr..ryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

DNtnqpLKLGGRFEVSLLKQTNYDSFVQRDIAVKHlqSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLAT-SQAPVVVHCSAGIGRTGALIAVD
|.      . |.. |.. ..  .. .  | ..|      .  |.  |..  ||| |||.. . .....  ..   | | ...|||||||.||||..|..|
dk....kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitld

VALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
  |  .| ..  |. . |. .|..|..|.|. .|| | |.| || .
avldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 49-124 2.5e-11 37.7 In-house 30-111 (347) alignment 
Range on Protein: 49-124
Range on HMM: 30-111/347.0
DSGKNQANTDKNRYRNVLPYEATRVRLSGS--------SGEDYINANHIRVlvDDDTYHYIATQGPLPNTTKDFWQMIWEQGVE
 | . . . .||| ..|   .|||| ||            | |||| ||.   |. . .|| || |||.| .|||.|.    | 
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikf..dnaskeyiltqyplpdtvrdfwkmvsvtkvt
0037934 (Phosphotyrosine protein) phosphatases II 50-289 2.8e-73 241.7 In-house 4-241 (243) alignment 
Range on Protein: 50-289
Range on HMM: 4-241/243.0
SGKNQANTDKNRYRNVLPYEATRVRLsgsSGEDYINANHIRVLvdDdtyHYIATQGPLPNTTKD----FWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWP
 .. ..| .||||...|||. .||.|   .|.||||||.|.|.  .   ..||||||||.|..|    ||.|.||.|..|. |.| ..| |..||..|||
iallpenlsknrysdilpydhsrvkl...egsdyinanliyvt..p...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

dntNQPlkLGGRFEVSLLKQTNYDSFVQRDIAVKHLQ-SGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRS---------LATSQAPVVVHCSAGIG
   ..     |.|.| ||.....|....| . ...|. .. . .. |. .. ||||||| ||  ...|. ..|.          . |. ||.||||||.|
...gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGALIAVDVALGLMerdkPFDINQTIRDLREQRQG-MIQTKDQYIFCYKACLEV
|||.||| .. | |.     .|. .....||||| | ..|| .||.|.|.| || 
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 51-293 1.3e-63 209.6 In-house 4-245 (250) alignment 
Range on Protein: 51-293
Range on HMM: 4-245/250.0
GKNQANTDKNRYRNVLPYEATRVRLSGSS---GEDYINANHIRVLVDDdtYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVkCHRYWP-D
.|. .| .|||| ...... .|| |  ..     ||||| .. .  .     .|||||||..|..|||.|..|. .... |.|  || .|. .|.||| .
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

NTNQplklGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATS--QAPVVVHCSAGIGRTGALIAVD
....     |   ||||.. ..  ...| . . . .  ..  . .|.|| ||| |||.    .....  ...      .|||.|.||||.||.|| ||.|
kaek....yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid

VALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSL
  |  ....|  |. . |. ||..| .......||.|.|.. |. |.|.
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 51-288 7.3e-46 151.3 In-house 3-239 (239) alignment 
Range on Protein: 51-288
Range on HMM: 3-239/239.0
GKNQANTDKNRYRNVLPYEATRVR---LSGSSGEDYINANHIRVlVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDN
 |.. |  |||| |.. |. .||    ||     |||||...|   |     |||||| .  .. |||.|.|..   |. |.|   || | |||.||||.
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrd.ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

TNQPLKLggrfEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMR--SLaTSQAPVVVHCSAGIGRTGALIAVDV
|..  .|     |.| |   .  .. | . . ..   .   . .  |  |||.|||.    .. .   .   ||     | |.|||||.|||||.. .| 
tskycnl....rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvida

ALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLE
 |   ...|  || . .. .||.|  |.|| .||.| . | ||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
0049772 (Phosphotyrosine protein) phosphatases II 51-292 2.5e-41 137.8 In-house 41-282 (314) alignment 
Range on Protein: 51-292
Range on HMM: 41-282/314.0
GKNQANTDKNRYRNVLPYEaTRVRLSG--SSGEDYINANHIRVLvdddtYHYIATQGPLPNTTKDF----------WQMI--WEQGVEVVAM--------
..  .| ||||| ..||.. .||.|.|   || |||||....         .|||||||..|  ||          |.|.  ... | .. |        
adlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------VTLDKEGGkvkchRYWPDNTNQPLKlggrfevsllkqtnydsfvqrdiAVKHLQSGKSIEIAHLNFVKWPDHGVPrSPVEMVQFVAY
              .   ..|      ...  . . ||                        . . ..  . .. ..  . .||...| ..  . .|...
elsrLdaAlgKtpllildgng.....neptaadlellk.......................eelydpelferlgikylripvpDgsap.lledfdeflef

MRSLaTSQAPVVVHCSAGIGRTGALIAVDVALGLMerdkPFDINQTIRDLREQRQ-----GMIQTKDQYIFCYKACLEVLKS
....   . ||.|||.||.|||| .....  . |.     ........|.|..|      |.|.. .||.|...| || || 
ieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_egg_pd Subfamily egg 51-287 1.9e-29 97.3 In-house 35-267 (307) alignment 
Range on Protein: 51-287
Range on HMM: 35-267/307.0
GKNQANTDKNRYRNVLPYEATRVRLS---GSSGEDYINANHIRVlvDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGgkVKCHRYWPDN
  .. | .| | . |   . .||.|    |   .|.| ||...   .    ..| .| || || .|||.|.... |. . |.|  ||    .|. |||  
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkG..kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

TNQPLKL-GGRFEVSLLKQTNYDSFVQRdiaVKHLQ-SGKSIEIAHLNFVKWpDhgVpRSPVEMVQFVAYMRSLATSQAPVVVHCSAGIGRTGALIAVDV
 ...|..  | ...  ||  .    . |   | .|.  |   |  .|.  .. |  | .   ..   .  .| |     ||||..  |. ....|.|...
esdslvtvpGslrienlkvdskadplfr...vtklklvGgddeerflehwqg.d..v.nnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaiei

ALGLMERDkP---FDINQTIRDLREQRQGMIQTKDQYIFCYKACL
||  . |  |   . . ...  || .|.  ...  .|.| |.  |
allsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 52-291 3.1e-56 185.3 In-house 34-278 (287) alignment 
Range on Protein: 52-291
Range on HMM: 34-278/287.0
KNQANTDKNRYRNVLPYEATRVRLS--GSSGEDYINANHIRVLVDDDTyhYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNtN
.. |.. |||| .|||.. ||| ||  |  | ||||||..    ||..  .||.|||.. | .|||....|. . .|...| . | .. ||..|||.. .
eelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddea..fiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.e

QPLKLGGrFEVSLLKQTNYD-SFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYM------RSLATSQAPVVVHCSAGIGRTGALIA
.|...|| . | ||.... .  .  | . . .|.. ..  .  |....|||.... . | ...||  .      .  |.   |.|||...||||.| |.|
vPmrvGG.ysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

VDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
. | .  .|     |. ...  |||.|....|.  |. . |.|     |
tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 52-291 7.4e-55 181.3 In-house 44-289 (325) alignment 
Range on Protein: 52-291
Range on HMM: 44-289/325.0
KNQANTDKNRYRNVLPYEATRVRLSG---SSGEDYINANHIRVLVDDDTyhYIATQGPLPNTTKDFWQMI--WEqgVEVVaMVTLDKEGGKVKCHRYWPD
   .| .|||..||.... .|| |     ..  |||||...|  .. |.  ..|.| ||..|..|.|...  |.    || .|.   ..|| .|  |||.
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdv..flaaqaPltatindlWrlvldWr..csvv.vvlneldlgkdrcavywpk

NTNQPLKLGGrFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYM---RSL----ATSQAPVVVHCSAGIGRTGA
.  .  ..|| .||.|    ..  .|.| . ||  . |..  .  ...  |.| ||.. |  .. ..  .          . . .|..||||||.||||.
emgksktfGg.levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

LIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
.|..  ||  .  .   || . .. ||..|  |..| ||||..|.|  |.. 
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 52-288 6.1e-46 151.5 In-house 3-238 (239) alignment 
Range on Protein: 52-288
Range on HMM: 3-238/239.0
KNQANTDKNRYRNVLPYEATRVR---LSGSSGEDYINANHIRVlVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNT
|.. |  |||| |.. |. .||    ||     |||||...|   |     |||||| .  .. |||.|.|..   |. |.|   || | |||.||||.|
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrd.ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

NQPLKLggrfEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMR--SLaTSQAPVVVHCSAGIGRTGALIAVDVA
..  .|     |.| |   .  .. | . . ..   .   . .  |  |||.|||.    .. .   .   ||     | |.|||||.|||||.. .|  
skycnl....rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdsl.pgarpwvihcsagvgrtgaflvidam

LGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLE
|   ...|  || . .. .||.|  |.|| .||.| . | ||
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 52-148 6.3e-15 49.4 In-house 92-182 (244) alignment 
Range on Protein: 52-148
Range on HMM: 92-182/244.0
KNQANTDKNRYRNVLPYEATRVRLS-GSSGEDYINANHIRVLvdDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVtldkeGGKVKCHRYWPDNT
 |  |. |||    ||..  || || || |. ||||  .  |    |  || || || .|. |||.|. |. |.|. ..     |   .   ||||  
fnpnnswknregaglpfdfnrvplskgsmgntyinasfvgcl..grtaeyiltqhpladtsmdfwkmmlerhvnvlvvl.....gsveeedeywpdse
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 53-293 3e-57 188.8 In-house 44-281 (287) alignment 
Range on Protein: 53-293
Range on HMM: 44-281/287.0
NQANTDKNRYRNVLPYEATRVRLSGSsGEDYINANHIRVLvdDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNqpL
 . | ||||....|...  || | |   .||||| .|      . ...|....|. || ..||..|... |... |.. .||  . .|..|||....  .
asqnkdknRltqilvpdnyrvllkge.hpdyinavfidgy..kekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..v

KLgGRFEVSLLKQTNYDSFVQRDIAVKHLQ-SGKSIEIAHLNFVKWPDHG-VPRSPVEMVQFVAYMRS-LATSQAPVVVHCSAGIGRTGALIAVDVALGL
 | | ....||... ......|.. ||. . .|.  ..   .. .|...| |..    ....   ...    .....|||||...||.. ..|.....  
vl.GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattink

MERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSL
 ...   |. | ..  | |. |..|| .||.| ... || |.| 
ckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 53-90 1.8e-07 25.1 In-house 36-75 (244) alignment 
Range on Protein: 53-90
Range on HMM: 36-75/244.0
NQANTDKNRYRNVLPYEATRVRLSGS--SGEDYINANHIR
  ||. |||| |.||.. ||| || |   | ||||||.|.
lsanatknryinilpfdetrvilssskkegsdyinanyiq
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 54-288 1.8e-64 213.1 In-house 59-289 (319) alignment 
Range on Protein: 54-288
Range on HMM: 59-289/319.0
QANTDKNRYRNVLPYEATRVRLS---GSSGEDYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTldkeggKVKCHRYWPDNTNQ
. | ||||. |.|... ..|.|    |  . ||||| ..      |   |||.||||.|| .|||.||||. .  . ..|      | || .||| ....
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd..kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

plkLGGRFEVSLLKQTNYDSFVQRDIAVKH-LQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSL---ATSQAPVVVHCSAGIGRTGALIAVDVA
     .||.|..   .. . .| ||| . .  .     .|    |  |||.||| .|......|  .| |      .|..|||||||.||||. |..|| 
...keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvl

LGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLE
|  |...|  |. ...||||.||. ..|   || |.| | ||
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 54-288 1.2e-63 210.3 In-house 23-253 (284) alignment 
Range on Protein: 54-288
Range on HMM: 23-253/284.0
QANTDKNRYRNVLPYEATRVRLS---GSSGEDYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTldkeggKVKCHRYWPDNTNQ
. | ||||. ..|... ..|.|    |  . ||||| .|      |   ||||||||.|| .|||.||||. .  . ..|      | || .||| ....
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkd..kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

plkLGGRFEVSLLKQTNYDSFVQRDIAVKH-LQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSL---ATSQAPVVVHCSAGIGRTGALIAVDVA
     .||.|..   .. . .| ||| . .  .  .  .|    |  |||.||| .|......|  .| |      .|..|||||||.||||. |..|| 
...keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl

LGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLE
|  |...|  |. ...||||.||. ..|   || |.| | ||
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 54-288 5.7e-42 138.4 In-house 53-287 (305) alignment 
Range on Protein: 54-288
Range on HMM: 53-287/305.0
QANTDKNRYRNVLPYEATRVRLSGSSGEDYINANHIRVLVDDDTyHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLK
. .  ||||..|   . . |.|.  |  ||| ||.. . .  .   .|..|||| .|  .|| |. .. || . |.    | ||.|| .|||    . |.
diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipek.rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

LGGRF---EVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRslaTSQAPVVVHCSAGIGRTGALIAVDVALGLM
| .     .||  |  . |. .|  .       .... . ||.. .||| |||   .  ..... .|    |. |.||||||||||||...|..  |  .
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair...gskvpivvhcsagigrtgtivaieyileki

ERDKPF-DINQTIRDLREQRQGMIQTKDQYIFCYKACLE
  .||   . . .. ||.||   ||.  ||.| ..  |.
aenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 54-286 1.7e-22 74.4 In-house 45-275 (303) alignment 
Range on Protein: 54-286
Range on HMM: 45-275/303.0
QANTDKNRYRNVLPYEATRVRLSGSSgedYINANHIRVlvdDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNqPLK
  | ||||. .|.  . ..|.|| ||   || |... .   | . . | || ||. |. |||||| || | .| ..  | |  |.  .  .| | .  ||
vknmdknrfvdvicldhskvklsdss...yihasylel...dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flk

LGGRF-EVSLLKQTN-YDSFVQRDIAVKHLQSGKSIEIAHLNfvKWPDHGVPRS-----PVEMVQFVAYMRSLATSQAPVVVhCSAGIGRTGALIAVDVA
.  |.  |  .|. .  | .| . ..|   .    . . | .  .||   .|         .. |  ...|  . |. .| .   .| ||.|..   . |
feersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvym.slsgcgragtfalfeta

-LGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKAC
 | | . .  .|. . .  .|. |   .|   |. . |   
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 55-295 7e-66 217.0 In-house 19-269 (270) alignment 
Range on Protein: 55-295
Range on HMM: 19-269/270.0
ANTDKNRYRNVLPYEATRVRLSGS---SGEDYINANHIRVLVDDDTYhYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQP
 ..  |||...||  ||||||.     |   |||||..|   ..... |||..||||.|.|.||.||||. |. ..|.|  .| |. || |||| .... 
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkk.YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

LKL-GGRFEVSLLKQTNYDSFVQRDIAVKhlQSGKSIEIAHLNFVKWPDHGVPRSPV------EMVQFVAYMRSLATSQ---APVVVHCSAGIGRTGALI
.||  |  .|  |.... . .... . ..  ..|.. .. |  ...||||||||..       .... .. .|   ...    |..||||||.|||| ||
vkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

AVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSLAQ
|.| |. |.|..|  |... |..||..|  ..|. .|| | ||| .|  . .|.
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerrak
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 55-292 2.7e-65 215.2 In-house 27-270 (274) alignment 
Range on Protein: 55-292
Range on HMM: 27-270/274.0
ANTDKNRYRNVLPYEATRVRLSG----SSGEDYINANHIRVlVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQ
 .. ||||...|| | .|| |.     ..  .|||||.|.   | ..  |.||||||||| .|||.||... |.|. |.|  ||  . ||..|.||... 
gsqtknryktilPnensrvllesessededssyinanyikG.ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

PL-KLGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSieIAHLNFVKWPDHGVPRSPVEMVQFVAYM---RSLATSQ-APVVVHCSAGIGRTGALIAVDV
 . .  | .|.   | .. . .  | . .|.|.. .|  . |  . .|||| .|... .....|. .   |. .. . |||||||||||||||. ||...
eiserygdveikvekiverndysvrklvlkylerers..vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
|.  .....  |. ... .|| .| ||.||..|| . ..|  . || 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 55-290 2.7e-38 126.7 In-house 42-271 (288) alignment 
Range on Protein: 55-290
Range on HMM: 42-271/288.0
ANTDKNRYRNVLPYEATRVRLSgSSGEDYINANHIRvlVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKL
||. ..||.|.   ..|||.||    . ||.|| .         . | .| ||  | . .|.|. |..|| . |..   | || |   |.| .  .  ..
anptrdryenlprcditrvkls.ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLatsQAPVVVHCSAGIGRTGALIAVDVALGLMERDK
|    |   |... |  |.  .   . .  ... . .| . .|.|.||| . .  ....  ..||   | |.|||.|||.||||.|| . .||  .  | 
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlksl...qkPivvhssaGvGrtgtlililialeslrldd

PFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
   |.. .  |||.|   |||. ||.. ..  || |
flgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 55-283 2.1e-30 100.4 In-house 51-283 (310) alignment 
Range on Protein: 55-283
Range on HMM: 51-283/310.0
ANTDKNRYRNVLPYEATRVRLS--GSSGEDYINANHIRVLVDDDTyhYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDN----T
 .  |||| .|.  ...||.|    |  |||| ||...     .|  .| .||||  |  |||.||...  | . ..    | |. ||  |||      |
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrst..ficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

NQPLKLGGRFEVSL-LKQTNY-DSFVQRDIAVKHLQ-SGKSIEIAHLNFVKWPDHGVPRSPVEMVQfvayMRSLAT-SQAPVVVHCSAGIGRTGALIAVD
   ...    | |  ..  |   .||  .. |       | . .. ... .||| |||   .  |      | ||   . |.|||||||..|.....|..
ygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagkdrlyvvvalk

VALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCY
...  ..| .  |... . .|. .|   |||. ||..  
lkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 55-211 8.9e-06 18.7 In-house 26-163 (169) alignment 
Range on Protein: 55-211
Range on HMM: 26-163/169.0
ANTDKNRYRNVLPYEATRVRLS---GSSGEDYINAnhirvlvdddtyhyiatqgplpnttkdfwQMIWEQGVEVVamVTLdkeGGKVKCHRYWPDNTNQP
.|  |||    |    |||.|       | |||||                             .||||    |.  | |   |.      .||.  .  
cnetknrpagplapshtrvklqrvmedlgsdyina.............................rmiwetnasvi..vvl...gdtddknnfwpekedyq

L----KLGGRFEVSLLKQTNYDSFV--------QRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQ
|     ||  .  ||  .|.             .  . ... ..  . ... | .  ||. |||.||| . .
lhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvgh
Y_phosphatase Protein-tyrosine phosphatase 56-288 3.3e-78 257.7 Pfam-A 1-235 (235) alignment 
Range on Protein: 56-288
Range on HMM: 1-235/235.0
NTDKNRYRNVLPYEATRVRLSGSSG-EDYINANHIRVLVDddTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKL
| .||||...|||. |||.|.||.| .||||||...   .  . ..|||||||..| .|||.|.|.. |.|..|.| ..| |..||..|||......|. 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GGrFEVSLL-KQT-NYDSFVQRDIAVKHLQSGK-SIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLA-TSQAPVVVHCSAGIGRTGALIAVDVALGLM
|  ..| |  |.. . .... |.. .|. .. . . |. .| . .|||||||.|| ......  ...   ....|||||||||.|||| ..|.|..|  .
gd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

ERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLE
|... .|. |... ||.||.||.|. .||||.|||.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 56-288 3.3e-78 257.7 In-house 1-235 (235) alignment 
Range on Protein: 56-288
Range on HMM: 1-235/235.0
NTDKNRYRNVLPYEATRVRLSGSSG-EDYINANHIRVLVDddTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKL
| .||||...|||. |||.|.||.| .||||||...   .  . ..|||||||..| .|||.|.|.. |.|..|.| ..| |..||..|||......|. 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GGrFEVSLL-KQT-NYDSFVQRDIAVKHLQSGK-SIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLA-TSQAPVVVHCSAGIGRTGALIAVDVALGLM
|  ..| |  |.. . .... |.. .|. .. . . |. .| . .|||||||.|| ......  ...   ....|||||||||.|||| ..|.|..|  .
gd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

ERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLE
|... .|. |... ||.||.||.|. .||||.|||.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 56-288 1.2e-53 176.8 In-house 3-237 (237) alignment 
Range on Protein: 56-288
Range on HMM: 3-237/237.0
NTDKNRYRNVLPYEATRVRLSGS-SGEDYINANHIRVLvDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDnTNQPLKL
|  |||| |.  |. .|| | |. || |||||.... . |    .|||.|||| .. .|||||.|..   |. |.|   || ..|||.|||. |.||   
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgf.dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpaay

gGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAH-LNFVKWPDHGVPRSPVEMVQFVAYM--RSLA-TSQAPVVVHCSAGIGRTGALIAVDVALGLM
 | . ||| |. ..  .  | . . . .. | . . |  .|  |||.|||.    ...|   .  ||   .  .| ..|||||.|||| .. .|  |   
.gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

ERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLE
.  |  || . .  . |.|  .|||||||.| ... ||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0041856 (Phosphotyrosine protein) phosphatases II 56-290 2.7e-50 165.8 In-house 1-171 (182) alignment 
Range on Protein: 56-290
Range on HMM: 1-171/182.0
NTDKNRYRNVLPYEATRvrlsgssGEDYINANHIRVLVDDDTyhYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTldkeggkvkCHRYWPDNTnqplklg
| |||||...|||. .|       . |||||| ..    ...  .|||||||..|. ||..|..|.|. .. ..|         ...|||..        
nldknrysdilpydhsr.......dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.......

grfevsllkqtnydsfvqrdiavkhlqsgkSIEIAHLNFVKWPDHGVPRsPVEMVQFVAYMRSlatSQAPVVVHCSAGIGRTGALIAVDvalgLMERDKp
                                .. .. .. |||||||  . |...|.  ...   .. ||.||||||.||||.|.| .    ||.. . 
..............................erlgiqylylpwpDhgvpd.ldelldfieevle...eggpvlVHCsaGvgRtgtlvaay....lmkklg.

FDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVL
... .... .|..| ||..| .||.|.. | ||.|
vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 56-280 6.9e-43 141.5 In-house 50-271 (301) alignment 
Range on Protein: 56-280
Range on HMM: 50-271/301.0
NTDKNRYRNVLPYEATRVRLSGSSGEDYINANHIRVLvdDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLg
. ||.|| .|     | |..        | || |      .. ..|||||||.||..||| |.    || ..|..   |  . ||. | | .... |.. 
pkdkhryptvPckPstavevivdGkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi.

GRFEVSLLKQTN--YDSFVQRDIAVKHLQS-GKSIEIAHLNFVKWPDHGVPRSPVEMVQFvayMRSLATSQAPVVVHCSAGIGRTGALIAVDVALGLMER
|||.. . ..     .. ..| . |.      ..  . | ....|.|.|||.| .|. ..   |  .  |. |.||||||||||. |.|. ..    .| 
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdl...melvkksekPivvhcsaGiGrsvafigteylarevea

DKPFDINQTIRDLREQRQGMIQTKDQYI
|.  ........|||.|   .||. |  
dptieltealkhlrehrwngvqtnsqly
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 56-292 2.7e-28 93.6 In-house 43-278 (312) alignment 
Range on Protein: 56-292
Range on HMM: 43-278/312.0
NTDKNRYRNVLPYEATRVRLSGSSgEDYINANHIRVLVDDDtyHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQpLKLG
  | ||| |.  ..  |  |.|   . || || ...    .  ....||||| ||.  |||.    |   . ...   | |  || .|  |     ..| 
fkdlnrypniqcwdrgrftlagde.nfyihanfvkictkpe..rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf.vdle

-GR------FEVSLlKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAymrSLATSQAPVVVHCSAGIGRTGALIAVDVALG
  |       |. .      |   .| . |    .|.   . | ..  |||||.| |     ....   ..   . ||. |||||.||||.|. ..  . 
dhrvyteycteiei.ggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrlls...avkkdkkpviahcsagvgrtgtlaliesmia

LMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKS
 .   .  .. ..   || .|   ...  ||... .. ||.| |
alrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 57-149 2.4e-28 93.9 In-house 48-155 (350) alignment 
Range on Protein: 57-149
Range on HMM: 48-155/350.0
TDKNRYRNVLPYEATRVRLS-----------GSSGEDYINANHIRVL----VDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCH
  ||||.|.|||| .||.|              |..||||||....       .  ..|||||.|||.| .||...| . .|.|. ..| | | .  ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPDNTN
|||.. . 
rYWqegsy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 57-148 2.7e-18 60.4 In-house 49-157 (349) alignment 
Range on Protein: 57-148
Range on HMM: 49-157/349.0
TDKNRYRNVLPYEATRVRLSGS-----------------SGEDYINANHIRVLVDDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVK
  ||||...|||| .||.|  |                   .||||||....   .   .||||| ||| | .||...|  .||..|  .. ||| .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CHRYWPDNT
|..|| . .
cdiywqels
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 59-283 5.7e-25 83.0 In-house 22-252 (290) alignment 
Range on Protein: 59-283
Range on HMM: 22-252/290.0
KNRYRNVLpYEATRVRLSGSS---GEDYINANHIRVlvdDDTYHYIATQGPLPNT-------TKDFWQMIWEQGVEVVAMVTLDKEGG----KVKCHRYW
..|... |  ||||| | |      .||| ||.. .    .  . |.|| |. ..        ..|| |. .  |. | |.   .|      .. | .| 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvtc...pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PDNTNQPLKLGGrFEVSLLKQTNYDSFVQRDIAVKHlQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRslaTSQAPVVVHCSAGIGRTGALIAVD
|.. .. ||..| ..|.  .. . | . .| . ||. . ..   . |  .. | .  |....  ... . ...   .|..||.|||  || |  || |..
pesvgeelkfkg.ltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvk...asktpvivHcvdGiSrsAalaaii

VALGLME-RDKPFDINQTIRDLREQRQGMIQTKDQYIFCY
..  ..    . . ... . .||.||. .|... .. |  
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvd
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 66-180 1.5e-11 38.7 In-house 3-104 (130) alignment 
Range on Protein: 66-180
Range on HMM: 3-104/130.0
LPYEATRVRlsgssGEDYINANHIRVLvdDDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVtldkeGGKVKCHRYWPDNtnQPLK-LGGRFEVSLLK
|..| .|..     |..||||. . .|  . |  |. || || .|. |||.|. |. |.|. ..     |   .   ||||   .||.    .  |.| .
lefevsrlq.....gntyinasfvGll..grtaeylltqhpladtsmdfwkmmleryvnvlvvl.....gsveeedeywpds..ePlewyeediivtltd

QTNYDSFVQRDIAVKH
. ...      . ...
rdefknikasnleies
0044763 (Phosphotyrosine protein) phosphatases II 68-287 2.7e-32 107.2 In-house 2-168 (178) alignment 
Range on Protein: 68-287
Range on HMM: 2-168/178.0
YEATRVRLSGSSG---EDYINANHIRvlvdddTYHYIATQGPlpnttKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNqplklggrfevsllk
.. ||| ||  .|    |||||..|        . |.....|      |......|.|. .. ..| ..|.|..||..|||....               
ldrtrvllsnleglersdyinaseil......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

qtnydsfvqrdiavkhlqsgksieiAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLA-TSQAPVVVHCSAGIGRTGALIAVDvalgLMERDkPFDINQTIR
                          .  .. .|||||| ..  . .||......  ... ||.||||||.||.|.|.| .    || .   ..... |.
.........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaay....lmkkl.glsleeaie

DLREQRQgMIQTKDQYIFCYKACL
 .||.|  .... .|. ..|.  |
lvrerRp.ivpnpgqlrqLyefel
0043147 (Phosphotyrosine protein) phosphatases II 79-283 2.8e-43 142.9 In-house 3-154 (172) alignment 
Range on Protein: 79-283
Range on HMM: 3-154/172.0
SGEDYINANHIRVLVddDTYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTlDKeggkvkchrywpdntnqplklggrfevsllkqtnydsfvqrdiav
.|.|||||... . .   . ..|||||||.||. |||.|..|.|. .. ..| .                                              
egsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnlt.el.............................................

KHLQSGKSIEIAHLNFVKWPDHGVPrSPVEMVQFVAYMRS--LATSQAPVVVHCSAGIGRTGALIAVDVALglmerdKPFDINQTIRDLREQRQGMIQTK
 .. .. . .. .. .. ||||||| ..  . .|. ....  .  .. ||.||||||.||||.|.| .  |      . ... .... .||.| |..|..
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

DQYIFCY
.||.|.|
sqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 80-293 1.1e-49 164.8 In-house 3-228 (272) alignment 
Range on Protein: 80-293
Range on HMM: 3-228/272.0
GEDYINANHIRVLvdddtYH------YIATQGPLPNTTKDFWQMiWEQGVEVVAMVTLDKEGGKVKCHRYWP---------DNTNQPLKLGGRFEVSLLK
 ..||||...  .     ..      .....||||.| .|||.. .|.|. .. ... . | |..||.||||          ..  |  | |.. | ||.
lsgyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtlls

QTNYDSFVQRDIAVKHL-QSGKSIEIAHLNFVKWPDHGVPRSPveMVQFVAYMRSlatsQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFD------
 .... .. | . ...| . |.. |. || .  |||||||...  ..........    . ||.||||||..||| ..|..  |  ....  .|      
eellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--INQTIRDLREQRQGMIQTKDQYIFCYKACLEVLKSL
  . .... ||.|| |..|| .||.|.|.| ||.|.||
lyleeaveelraqrpgavqteeqylflyeallellrsl
0036282 (Phosphotyrosine protein) phosphatases II 80-284 2.9e-45 149.4 In-house 1-164 (174) alignment 
Range on Protein: 80-284
Range on HMM: 1-164/174.0
GEDYINANHIRVLVDDDtyHYIATQGPLPnttkdFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDntnqplklggrfevsllkqtnydsfvqrdiavk
|.|||||... . .  .  ..||.||||.     ||.|..|.|...| |..  || |..||..|||.                                 
gsdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

hLQSGKSIEIAHLNFVKWPDHGVPRSPVeMVQFVAYMRSLATS--QAPVVVHCSAGIGRTGALIAVDVALGLMErDKPFDINQTIRDLREQRQGMIQTKD
 |..  . .. .. .. ||||||| ... . .|| ....   .  . ||.||||||.||||.|.| .  | ...  .. |. ...| || || ||.|| .
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYIFCYK
||.|.|.
Qyrflyy
0046846 (Phosphotyrosine protein) phosphatases II 81-291 3.4e-45 149.2 In-house 12-174 (176) alignment 
Range on Protein: 81-291
Range on HMM: 12-174/176.0
EDYINANHIRVlvdddtYHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLklggrfevsllkqtnydsfvqrdiavkh
 |||||| |        ...||||||||.|. ||..|..|.|...| ..| ..| |..||..|||. ..  .                            
ldyinanlilg......srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

lqsgksieiaHLNFVKWPDHGVPRSpVEMVQFVAYMRSLATSQAPVVVHCSAGIGRTGALIAVDvalgLMERDKPFDINQTIRDLREQRQ-GMIQTKDQY
          .  .. ||||||| .   . ......|.  ..  ||.|||||||||||.|.| .    |.|..| ........ .||||  |..|| .||
..........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQy

IFCYKACLEVLK
 |.|.. |..||
rflyefellllk
0051082 (Phosphotyrosine protein) phosphatases II 81-286 8.6e-37 121.4 In-house 3-149 (151) alignment 
Range on Protein: 81-286
Range on HMM: 3-149/151.0
EDYINANHIRvlvdDDtyhYIATQGPLPnttkDFWQMIWEQGVEVVAMVTLDKEGGkvKCHRYWPDNTnqplklggrfevsllkqtnydsfvqrdiavkh
.||||.. .     .    .....|||.    ||.....|.|. .. ... ..| |  .|..|.|..                                 
sdyinfsyvt....gg...lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

lqsgksIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSlaTSQAPVVVHCSAGIGRTGALIAVDVALgLMerdkpFDINQTIRDLREQRQGMIQTKDQYI
      ||. |. .. |||.|.| |. ....|. ....  ... ||.||||||.||||.|.|..  | |.     ..........|..| |..|...|..
......ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqfl

FCYKAC
|...| 
fqlfal
0049260 (Phosphotyrosine protein) phosphatases II 98-284 2e-41 136.5 In-house 9-144 (152) alignment 
Range on Protein: 98-284
Range on HMM: 9-144/152.0
YHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWpdntnqplklggrfevsllkqtnydsfvqrdiavkhlqsgksieiaHLNFVKW
...||||||.|||..|||.|..|.|. .. |.| . | ||.||..|.                                              .  .. |
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................qylhlpw

PDHGVPRSPVEMVQFVAYMRS-LATSQAPVVVHCSAGIGRTGALIAVDVALglmerdKPFDINQTIRDLREQRQGMIQTKDQYIFCYK
|||||| ..  . ...  ..  .  .. ||.||||||.||||.|.| .  |      . ... .... .||.| |......|..|.|.
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 98-284 2.2e-24 80.7 In-house 5-198 (199) alignment 
Range on Protein: 98-284
Range on HMM: 5-198/199.0
YHYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKS-IEIAHLNFVK
 .||||| || .|  |||||.|| |   . ||  |.   ..    |||   .   | |    ..    |. |  .   | ..   .  |  ||.| .|  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPRSPVeMVQFVAYMRSLAT-----SQAPVVVHCSAGIGRTGALIAVDVALGLMERDKP--FDINQTIRDLREQRQGMIQTKDQYIFCYK
| ..  |   . .| ||   | ..       .|||.|||| | | || ..|.|. .   |  |    |. .  . ||. | |.| . ..| | |.
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 99-284 2.2e-24 80.7 In-house 5-197 (198) alignment 
Range on Protein: 99-284
Range on HMM: 5-197/198.0
HYIATQGPLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLGGRFEVSLLKQTNYDSFVQRDIAVKHLQSGKS-IEIAHLNFVKW
.||||| || .|  |||||.|| |   . ||  |.   ..    |||   .   | |    ..    |. |  .   | ..   .  |  ||.| .|  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPRSPVeMVQFVAYMRSLAT-----SQAPVVVHCSAGIGRTGALIAVDVALGLMERDKP--FDINQTIRDLREQRQGMIQTKDQYIFCYK
 ..  |   . .| ||   | ..       .|||.|||| | | || ..|.|. .   |  |    |. .  . ||. | |.| . ..| | |.
kekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 106-282 1.8e-25 84.0 In-house 99-280 (302) alignment 
Range on Protein: 106-282
Range on HMM: 99-280/302.0
PLPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLGgRFEVSLLK-QTNYDSFVQR------DIAVK--HLQSGKSIEIAHLNFVK
|  .|.. .| .| .  | .|. ..  .|... ||  |. |. .. ||.| |. |  .. .|. . |  .       . .|  . .. .   .  | |  
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfg.rytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPRSPVEMVQFVAYMRSLATSqapVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFC
||||| |. .   .. . .  |  ..   |.||||||.||||.|.|.   . |  ..|  |. . .  .|. | | .|...| |. 
wpdhGapkeaytaldilkfcesykkn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 107-289 1.6e-17 58.3 In-house 43-226 (263) alignment 
Range on Protein: 107-289
Range on HMM: 43-226/263.0
LPNTTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLGgRFEVSLLKQTNyDSFVQRDIAVKHLQ-SGKSIEIAHLNFVKWPDHGVPRS
| .| . |.|.|  .. |||.|..  .| |..|| .|.| . .. .||    .|.  |  . |  ..    .. |.   |  .. |  .. |...  |. 
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla.nvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpel

PVEMVQFVAYMRSLatsqAPVVVHCSAGIGRTGALIAVDVALG----LMERDKP--FDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
. |... .   | .     ..|||||.||||. |   ....       ..  .   .|  . ...||..|.. |.|  |  |     |..
areilnilkvarns....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 110-289 2.5e-20 67.6 In-house 40-220 (255) alignment 
Range on Protein: 110-289
Range on HMM: 40-220/255.0
TTKDFWQMIWEQGVEVVAMVTLDKEGGKVKCHRYWPDNTNQPLKLGgRFEVSLLKQTNYDSFVQRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEM
| . |.|.|  .. |||.|..  .| |..||..|.| . .. |||    .|.  | ..   .  ..|  .  .  |  .. | ..  |...  |. . |.
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla.dvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

VQFVaymrSLATSQAPVVVHCSAGIGRTGALIAVDVALG----LMERDKP--FDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
 . .     ...   .||||||.||||. |.. ....       ... .   .|  . ...||..|.. |.|  |  |.    |..
lnil....kvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
0048076 (Phosphotyrosine protein) phosphatases II 173-287 3.5e-26 87.0 In-house 31-140 (145) alignment 
Range on Protein: 173-287
Range on HMM: 31-140/145.0
QRDIAVKHLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQAPVVVHCSAGIGRTGALIAVDvalgLMERDKpFDINQTIRDLREQRQGM
 . . . . ... . .. .. .. ||||||| ..  . .|.......  .  ||.||||||.||||.|.| .    || . . ... .... .|.|| |.
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpga

IQTKDQYIFCYKACL
... .|..|.|.. |
vpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 180-284 3.2e-25 83.9 In-house 40-139 (144) alignment 
Range on Protein: 180-284
Range on HMM: 40-139/144.0
HLQSGKSIEIAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQAPVVVHCSAGIGRTGALIAVDvalgLMERDKpFDINQTIRDLREQRQGMIQTKDQY
. .     |. .. .. ||||||| ..  . .|.......  .  ||.||||||.||||.|.| .    || . . ........ .|..| |.... .|.
yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgql

IFCYK
.|...
rfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 184-290 3.9e-18 60.0 In-house 86-194 (440) alignment 
Range on Protein: 184-290
Range on HMM: 86-194/440.0
GKSIEIAHLNFVKWPDHGVPRS--P-VEMVQFVAYMRSLAtSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYI
 .|  . . ..  |||.|||.   | ..|.| |   .  | ...|..|||||| |||| .||||  |   .|    ||   |  .|..|  |.|| .|| 
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FCYKACLEVL
| ..| || |
fvheavlegl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 185-288 4.4e-18 60.1 In-house 213-342 (350) alignment 
Range on Protein: 185-288
Range on HMM: 213-342/350.0
KSIEIAHLNFVKWPDHGVPRSPVEMVQFVA-----------YMRSLATSQAPVVVHCSAGIGRTGALIAVDVALG-------LMERD-------KPFD-I
   .. .|.. .|.| ..   | ...| .               .    ..|..||||||.|||| |...|  |        | ..        | .| |
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

NQTIRDLREQRQGMIQTKDQYIFCYKACLE
....  ||.||  |.|..||.||.|.| | 
siivnelrkqrismvqnldqfifiYeallf
subfamily_PTPDC1_pd Subfamily PTPDC1 188-282 8.8e-13 43.1 In-house 82-168 (182) alignment 
Range on Protein: 188-282
Range on HMM: 82-168/182.0
EIAHLNFvKWPDHGVPrSPVEMVQFVAYMRSLATSQaPVVVHCSAGIGRTGALIAVDVALglmerDKPFDINQTIRDLREQRQGMIQTKDQYIFC
.|.. ||  |.|.||. |  .... |  . .  . .  | ||| || |||| |||. .        | .. ...|. .|..|   |||..|  ..
giyvynf.gwkDygva.sleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvy.....akrltaekaiklvrskrpksiqtreqvelv
PTPc_DSPc_SM00012 189-288 3.2e-34 112.6 In-house 2-105 (105) alignment 
Range on Protein: 189-288
Range on HMM: 2-105/105.0
IAHLNFVKWPDHGVPRSPVEMVQFVAYMRSLATSQ---APVVVHCSAGIGRTGALIAVDVALGLMERD-KPFDINQTIRDLREQRQGMIQTKDQYIFCYK
. |. . .|||||||... ...........  . .   .|||||||||.|||| ..|.|..|  .|.  | .|| |... ||.||.||.||..||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ACLE
|.||
alle
0038934 (Phosphotyrosine protein) phosphatases II 196-284 7.6e-12 40.7 In-house 86-171 (194) alignment 
Range on Protein: 196-284
Range on HMM: 86-171/194.0
KWPDHGVPRSPVEMVQFVAYMRSLATS--QAPVVVHCSAGIGRTGALIAvdvaLGLMERdKPFDINQTIRDLREQRQGMIQTKDQYIFCYK
 .||.|.. |   . .|.  .        .  |.||| ||.|||| |.|      |..|   .. .. |. .|| |.|.|.. |..   .|
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva....aYLiyr.lgmsaeeAialfrekRpgaipnqdyleallk
PTEN_1 196-278 1.5e-10 36.2 In-house 101-181 (196) alignment 
Range on Protein: 196-278
Range on HMM: 101-181/196.0
KWPDHGVPrSPVEMVQFVAYMRSLATS---QAPVVVHCSAGIGRTGALIAvdvaLGLMERDKpFDINQTIRDLREQR-QGMIQTKDQ
 ..|||.| |  |.  ... . . . |   .  |.||| ||.||.| ..|      ||.. | .. ..... .||.| .|....  |
pieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva....ayLmykgk.ltadeAlelvrekRppgapnspsq
subfamily_DSP23_pd Subfamily DSP23 196-279 2.6e-08 28.6 In-house 58-135 (148) alignment 
Range on Protein: 196-279
Range on HMM: 58-135/148.0
KWPDHgVPRSPVEMVQFVAYMRSLATSQAPVVVHCSAGIGRTGALIAVDVAlglmeRDKPFDINQTIRDLREQRQGMIQTKDQY
. .|.  | .. ..|.||  .      .  | |||  | ||||...|  .      . . .   ..| ..|..| | ..| .| 
riddy.hppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylv.....kerklaaaeaiaevrrlrpgsvetveqe
subfamily_CDKN3_pd Subfamily CDKN3 198-282 1.4e-06 22.0 In-house 108-188 (202) alignment 
Range on Protein: 198-282
Range on HMM: 108-188/202.0
PDHGVPrSPVEMVQFVAYMRSLATSQAPVVVHCSAGIGRTGALIAVdVALGLMERDKPFDINQTIRDLREqrQGMIQTKDQYIFC
.| .|| .. . ....  .|    ..   .|||  |.||.  .||  . | | .  .| |  . .|||.    . |||  || . 
adglvp.diasclkileelrinlkayrktlvhcygglgrsslviac.lllylddtiepkdaidklrdlkg..sraiqtvkqynyl
DSPc Dual specificity phosphatase, catalytic domain 208-280 2.2e-08 29.1 Pfam-A 58-124 (133) alignment 
Range on Protein: 208-280
Range on HMM: 58-124/133.0
EMVQFVAYMRSLATSQAPVVVHCSAGIGRTGALIAVdvalGLMERDKpFDINQTIRDLREQRqGMIQTKDQYI
|. . |..........  |.||| ||| |...||..     ||.... ...|. .. ..|.| ..|  .....
eleeavefiekaeqkgkkvlVHCqaGisRSatliia....Ylmktkn.lslneAyefvkerr.skispnagfl
DSPc Dual specificity phosphatase, catalytic domain 208-280 2.2e-08 29.1 In-house 58-124 (133) alignment 
Range on Protein: 208-280
Range on HMM: 58-124/133.0
EMVQFVAYMRSLATSQAPVVVHCSAGIGRTGALIAVdvalGLMERDKpFDINQTIRDLREQRqGMIQTKDQYI
|. . |..........  |.||| ||| |...||..     ||.... ...|. .. ..|.| ..|  .....
eleeavefiekaeqkgkkvlVHCqaGisRSatliia....Ylmktkn.lslneAyefvkerr.skispnagfl
PTPc_motif_SM00404 208-279 5.7e-07 24.5 In-house 65-130 (140) alignment 
Range on Protein: 208-279
Range on HMM: 65-130/140.0
EMVQFVAYMRSLATSQAPVVVHCSAGIGRTGALIAVdvalGLMERDKpFDINQTIRDLREQRqGMIQTKDQY
.. . ...... ....  |.||| ||. |...||..     ||.... ..... .. ..|.|  .|. . ..
yldkvldfienaekkggkvlVHCqaGvSRSatliia....Ylmryrq.lslaeayefvkerR.piispnlnf
Y_phosphatase3 Tyrosine phosphatase family 211-243 3.3e-06 22.2 Pfam-A 112-144 (164) alignment 
Range on Protein: 211-243
Range on HMM: 112-144/164.0
QFVAYMRSLATSQAPVVVHCSAGIGRTGALIAV
.. .... ||... ||..||.||  ||| ..|.
ayrkvlealaeeegpvlfHCtaGKDRTGvvaal
subfamily_CDC14_pd Subfamily CDC14 215-279 5.2e-08 27.1 In-house 255-314 (328) alignment 
Range on Protein: 215-279
Range on HMM: 255-314/328.0
YMRSLATSQAPVVVHCSAGIGRTGALIAVDvalgLMeRDKPFDINQTIRDLREQRQGMIQTKDQY
... . ...  ..||| ||.||||.|||.     || ..  |  ...|  ||  | |.. .. | 
fleiaekaeGaiavhCkaGLGrtGtLiacy....lm.khyrftaaeaiawlricrPGsvigpqqk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 216-291 1.9e-16 54.8 In-house 221-296 (297) alignment 
Range on Protein: 216-291
Range on HMM: 221-296/297.0
MRSLATSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
.|.    .|...||||||.||.| ..  || |  . ...  |..  .. |||||  ..|| .|. ..|.| |. ||
lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklk
subfamily_PRL_pd Subfamily PRL 216-284 2.4e-07 24.9 In-house 83-146 (151) alignment 
Range on Protein: 216-284
Range on HMM: 83-146/151.0
MRSLATSQAPVVVHCSAGIGRTGALiavdVALGLMERDkpFDINQTIRDLREQRQGMIQTKD-QYIFCYK
..   .... | ||| ||.||.  |    ||| |.|    .. ..... .||.|.| | .|  ...  ||
ekfkeepkstvavhcvaGlGraPvl....valalieaG..mkyedavefirekrrgainskqlkflekyk
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 217-291 1.2e-06 20.4 In-house 234-308 (327) alignment 
Range on Protein: 217-291
Range on HMM: 234-308/327.0
RSLATSQAPVVVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
.|.     ||...   || |. .     . |  .|. . ||.   |. . . |.| | |  |. ||   ||.. |
ksmenfvppvmlqsfdginrastgwvalmllrdvekrecfdvpslikaimkfrngsistyyqfcfcmavclnigk
subfamily_CG42327_pd Subfamily CG42327 221-289 3.7e-19 63.5 In-house 245-314 (319) alignment 
Range on Protein: 221-289
Range on HMM: 245-314/319.0
TSQAPVVVHCSAGIGRTGALIAVDVALGLMERD-KPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEV
 || |.||||| |.|||| .|| |.|.  .|   .  || |..  .|..|   ..||.|| | ||   | 
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 221-288 7.4e-11 35.9 In-house 263-342 (349) alignment 
Range on Protein: 221-288
Range on HMM: 263-342/349.0
TSQAPVVVHCSAGIGRTGALIAVDVALGLME-----------RDKPFD-INQTIRDLREQRQGMIQTKDQYIFCYKACLE
   ....|||||| |||| |. .|. | ..|           . . .| |  ..  || ||  |.|   |.|..|.| |.
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 227-291 5.5e-12 39.9 In-house 2-66 (69) alignment 
Range on Protein: 227-291
Range on HMM: 2-66/69.0
VVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
|||||.| ||||..||. | .  .  .|  ||   .. .|  |  |.  . .||| . |  | ||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 227-291 1.6e-11 38.4 In-house 1-65 (69) alignment 
Range on Protein: 227-291
Range on HMM: 1-65/69.0
VVHCSAGIGRTGALIAVDVALGLMERDKPFDINQTIRDLREQRQGMIQTKDQYIFCYKACLEVLK
|||||.| ||||..||. | .  .  .|  ||   .. .|  |  |.  ...|.| . |  | ||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
subfamily_ptpA1_pd Subfamily ptpA1 256-288 8.9e-07 23.0 In-house 364-396 (418) alignment 
Range on Protein: 256-288
Range on HMM: 364-396/418.0
FDINQTIRDLREQRQGMIQTKDQYIFCYKACLE
|..   .  ||||| ||.|  .||.||||. |.
fnlfsivlklreqrpgmvqqleqylfcyktild