Gene PTPN23 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN23
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP075_AA protein Get Run
NvecP075_AA_1194-1392 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
BRO1 BRO1-like domain 2-323 1.6e-101 328.0 Pfam-A 55-375 (377) alignment 
Range on Protein: 2-323
Range on HMM: 55-375/377.0
DHSGCSILRRYFAQLQFLQSRFPmaeGGAIPVQFTWTDLY-SEEPISLADVRFEQASILHNLGALHSLLGKNEDRTGEEGMKVACTHFQAAAGVFQYLKD
| ||.. | ||.|||..|..|||      . |.|||.| . ...|.......||.||.|.||.||.| ......|. .||.| |...||.|||.|.|||.
desglelllrYyaqLellekrfp...drslkveFtWydafdtgsplaqrslafEkasvlFnlaalysqiaasqnrssdeglkaAvkyfqrAaGafeylke

HFATEAFFDMASCLLQLYISVMLGQAQECLLEKSILDGRKDSLIARISVQVHDFYQEGlafLESLGSSYMGSKKAKIWTKALKIKACHYMAVAYIFMSNN
.|  .   |... .|.. ...||.|||||.|||.|||..||||||... || |.|.|    ||.| .|   ..  | |.| ...||... |.|. .....
nflhapseDlspetlkvlvklmlAqAqecflekaildkkkdsliaklaaqvadlYeea...lealqesptktgipkewaklvqvKaeyfkAlahyyqala

ANENQKFGEKVSYLKAASKKLGEAQKLVKG--QPERTQEILQFMVDVVSNKLEGAVKDNDFIYHEVVPELSALPEIKGASLVKPIPFQPND--PSLAGPD
..|..|.||.. .|..| ..| ||||| |.  ...  .| |... ... .||| | |||||||.| ||. . |..||.|.|||..|.. ..  ..  |.|
leekkkyGeaiarLqeAlellkeaqklakkckskselledlkelkerikekleeaekdNdfiyleevpdeveltsikkaklvkalpinellsltkekged

IFKRLIPMEAHTDASLYSEEKAKLLRR
.||.| |...|  |||||||||||.|.
lfkklvPiavheaaslyseekaklvrd
ALIX_LYPXL_bnd ALIX V-shaped domain binding to HIV 355-639 1.4e-53 170.1 Pfam-A 6-295 (296) alignment 
Range on Protein: 355-639
Range on HMM: 6-295/296.0
TLPPMLKEKNEILRcDPEELVKIDQNIKDLQKLSDNIESTLKSVSYLIDEDEEKENEAKALFGP--MQAPKER--EEIKSELDKNLKTHAIACKTNNELM
.||..|.|| | || ..... .... ..||..|....||.|. .. ..||.|..... .. .|.   ..| ..  .|...|| |  .... | .....| 
glpesllekaeelr.seggiesleeslddleelkqavesildeakeqLdeeesedeklrskygarwtrqpsseltaelreelrkyreaLeeAsesDsqlr

RAYKSHLANLELLVGPQEVLLASLPSPNIIDSPVDDGAVQRLRDLIAKVDHMKSQRKQLEEDLRREINADDITGLLV---TREEGSKQAFFDEQLKKHSH
...... ..|.|| .| | | ||||| .  .|. .. ...|||.|  |.. .|..|..|.|.|...|. |||. .|.    ... .....|.|.|.|.. 
skleeieedlalLsspeeeleaslpssspeesdevseqikrlrelleklnllkaeRaklleeLkekihdddiskilielnkksssneeqlfeeeLekfdp

TCSLIQANLDAQDRILSALTEANAKYAPMRQAvKENSQKREDVAKGLILSYNVLCELKGKVSRGLQFFQNLEAKVDKLEEKCKNFFDQHGQE
  . ..... .|...|..|.|||.... ...  |.....||.| . |  .|..  ||. ... ||.|...|. ....|....| | ..  .|
lqerleqsiskQssllkelkeaneeflqdkks.kyekkerekvlqklenaydkykelssnleeglkFYndLlkileslrknvkdfvnarrsE
subfamily_PTPN1_pd Subfamily PTPN1 1162-1384 3.5e-38 126.0 In-house 30-256 (290) alignment 
Range on Protein: 1162-1384
Range on HMM: 30-256/290.0
PGQKHQQPFRPEQPFQP---GLQPQKVTYLFFSQKETTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNL-FG
|  . .  .|  .|..     |. ... |.  |  |   .   .| ||||...| . ||.|||||.|  .||| | || ...||.|||| .| . .| . 
penrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellle

--PMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinHTFTWSVIGVPKSPEDLIAFMGEVETCYTETEGEGgkPIILHCSAGVGRTGTFCVIFSAI
   ..| | |  ..  ...|.....         . |   |  ||.  |||.||  .. |. .|  . . ..  |  | ..|||||.||.||||.. . .
dtklkvkliseerksyytvrllelenlktqetreilhf..hyttwpdfgvpespaaflkflfkvresGslssdvG..pavihcsaGiGrsGtfclvdtcl

REFTAHNG--IINIPRMVRTLRQQRKYMVQK
 .  ...    ..| ...  ||..|  ..| 
vliekkddlssvdikkvllelrkyrlGliqt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1184-1383 3e-29 96.7 In-house 69-277 (301) alignment 
Range on Protein: 1184-1383
Range on HMM: 69-277/301.0
KVTYLFFSQKETTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHND
. .|.  |  . .  .  |||.|||. .||.||| ..|...   |||.|.. || | ||.||||  | ... |||. | |.. .  | .. | . .. .|
qreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqd

VST---VYLVCHVINHTFTWSVIG--VPKSPEDLI-----AFMGEVETCYTETEGEGGKPIILHCSAGVGRTGTFCVIfSAIREFTAHNGIINIPRMVRT
.|    .    .| ..  .|.|.   | . |.| .       .  ..     .   || |.. |||..|.|.|..| . |   |    .|....  ....
gsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsv.siglEQckaegVVdvfqvtka

LRQQRKYMVQ
.|...  .|.
vrrskpgaVt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1187-1384 2.5e-39 130.0 In-house 74-262 (315) alignment 
Range on Protein: 1187-1384
Range on HMM: 74-262/315.0
YLFFSQKETTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVST
|.  |. ..      .||.|||  ... ||| ||....   |||.||  ||.|.|| ||||  ....  || ..|.| || .  . . | . ... . | 
yinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesr

vylvcHVINHTF-TWSVIGVPKSPEDLIAFMGEVETCytetEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFtAHNGIINIPRMVRTLRQQRKYMVQK
      | .. |  |   ||.|    |. .. || .     .|.   ....|||||||||| .. | . . .  ...  ... ..|..||..| |.|| 
.....tvtqfqftewPdkGvdkqtssllklikevkad....ngkkefsllvhcsaGvGrtGvvisidevvaqi.krtrsvdvfnfvknlrakrpylvqt
subfamily_eak_pd Subfamily eak 1187-1316 5.6e-10 33.1 In-house 80-204 (332) alignment 
Range on Protein: 1187-1316
Range on HMM: 80-204/332.0
YLFFSQKETTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDvsT
|.  |  | . .   .| |  .  . .  || || ||.|| ||.| ..|| .  |  .|.| .  .   || . |  |.         | . ..  .   
yinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGn..e

VYLVCHVinHTFTWSVIGVPKSpEDLIAFM
 . | |   . | |. . .||  ||..|. 
thrvlhy..kvfGwtettlpky.edflalr
subfamily_PTPN23_pd Subfamily PTPN23 1193-1392 1.9e-88 291.0 In-house 76-273 (288) alignment 
Range on Protein: 1193-1392
Range on HMM: 76-273/288.0
KETTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCH
|. .|..|.|||||.|..|||.||||||.||.|.|||||... | .| |...||| |.|.|. ||...|.||| .... ...||......|...|. |.|
kdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvsh

VinHTFTWSVIGVPKSPEDLIAFMGEVETCYTETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKKVILQKLY
.  ....|. .|||.|||.|..|..|||..|.... .  .|...||||||||||.|.....|.||....||...|...|..||.||..|||.| .|...|
l..qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1193-1385 8.3e-38 124.9 In-house 68-252 (283) alignment 
Range on Protein: 1193-1385
Range on HMM: 68-252/283.0
KETTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPiDEGhTNLFGPMRVSLKSLTSSPGWIRRVMHIQHN-DVSTVYLVC
..    .  .|..|.|.  |  ||| ||....   ||||||  |... || ||||  .| .  .|.. |.|.  |.|  .|.. . ...|    .  |..
sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP.krG.sedyGeftvtlrkettsnsfiikelllrvnssakstllla

HVinHTFTWsvigVPKSPEDLIAFMGEVETCYTETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAhNGIINIPRMVRTLRQQRKYMVQKK
|       |    .  ...  |  .  ..   .    .   ||..|||.|.|||..|. . ... .  . . ..... .|. .|.||  .||..
hy..qvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdalt.esvvdvfavvkimreqrmmavqtl
subfamily_PTPRN_pd Subfamily PTPRN 1194-1385 1.3e-32 107.7 In-house 94-278 (297) alignment 
Range on Protein: 1194-1385
Range on HMM: 94-278/297.0
ETTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPiDEGHtNLFGPMRVSLKSL-TSSPGWIRRVMHIQHNDVSTVYLVCH
.. | .| .||||||.|||.|||| ||||| . |||.||.  | .  .|..||| |||. ....   | | |    .  .. | ....  . |    |  
dhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp.deGs.evyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtq

VinHTFTWSVIGVPKSPEDLIAFMGEVETCYTeteGeGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKK
   | ..|   ||| |.  |. |   |. .|    |    ||..|||.|.||||....|   .  ..     |.|   .  ||.||. .|. |
f..hflswpeegvPasaksllefrrkvnksyr...G.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktk
0040439 (Phosphotyrosine protein) phosphatases II 1195-1390 1.6e-48 160.9 In-house 49-237 (249) alignment 
Range on Protein: 1195-1390
Range on HMM: 49-237/249.0
TTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIdeGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVI
.. ... |||||||  .|..||| |.||... ||||||..|| .. ||.||||   |..  .| ..| |.| ........|.......  .... | |. 
gyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

NHTFTwsVIGVPKSPEDLIAFMGEVETCYTETegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGiINIPRMVRTLRQQRKYMVQKKVILQK
 . .     |||.|.|||..|. .|.....|.  . |.|.. ||||||||||||.... ... .  ..| ....  |..||.|| ..||    .. 
ytdwp..dhgvppsfedlldfieavrkaleel..pkggpvlVHCsaGvgRtGtfiaaylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrf
0043147 (Phosphotyrosine protein) phosphatases II 1195-1392 5.9e-26 86.6 In-house 15-154 (172) alignment 
Range on Protein: 1195-1392
Range on HMM: 15-154/172.0
TTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEvegnklkchqywpideghtnlfgpmrvslksltsspgwirrvmhiqhNDVSTVYLVCHVI
..   . |||||||  .|||||| |..|..  .||.||..                                                   . .    . 
lyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................lydpellerlgiq

NHTFTWSVIGVPkSPEDLIAFMGEVETCYtetEGEGGKPIILHCSAGVGRTGTFCVIFSAIreftahNGIiNIPRMVRTLRQQRKYMVQKKVILQKLY
 . . |   ||| ..| |. |.  ... .     . |.|.. |||||||||||.....  .       |. ..   |...|..| ..|| .  .. ||
ylylpwpDhgvp.llellleflefidell...alspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyrfly
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1195-1386 4.3e-22 73.1 In-house 83-223 (392) alignment 
Range on Protein: 1195-1386
Range on HMM: 83-223/392.0
TTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNklkchqywpideghtnlfgpmrvslksltsspgwirrvmhiQHNDVSTVylvchVI
.      .||.||| |..| ||| ||....   |.|.||  ||.                                         . .|. ||       
sfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........................................kgddartv.....aq

NHTFTWSVIGVPKSPEDLIAFMGEVETCYteteGEGGKPIILHCSAGVGRTGTFCVIFSAIReFTAHNGIINIPRMVRTLRQQRKYMVQKKV
 |   |   .|||    |. |. ||.. .    |.  .|.|.||||||||||    | | .  .. .  ....  .|  .|..| |||| | 
fhftewPdkdvpkhtssllkfikevkadf....Gqythpliihcsagvgrtgvvisidsvva.hakktrmvdvfnfvtnirrkrpymvqtke
subfamily_egg_pd Subfamily egg 1195-1385 1.3e-16 55.1 In-house 78-256 (307) alignment 
Range on Protein: 1195-1385
Range on HMM: 78-256/307.0
TTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNklKCHQYWPIDEGHTNLF--GPMRVSLKSLTSSPGWIRRVMHIQHndVSTVYLVCH
  |.   || .| |.  |  ||| ||.... . |||||  .| .  .|. |||  | ..  .  | .|.    . | .  . || ...   | .     .
Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgddeerf

VINHTFTWSVIGVPKSPEDLIAFMGEVetcytetegegGKPIILHCSAGVGRTGTFCVIFSAIREFTAHnGI--INIPRMVRTLRQQRKYMVQKK
.      .   .   ||  ..  . ..            ||.....  || ...|.  |  |. ..     |    . | |  ||..|.. |.  
lehwqgdvnnssdvysplrvlrklrnl...........skpvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1195-1386 9.4e-14 45.7 In-house 89-277 (310) alignment 
Range on Protein: 1195-1386
Range on HMM: 89-277/310.0
TTPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPiDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVI
|  .   || .|||.  |. ||| |......  |..| | .|  . ||  |||   | |. .| .||.  | .|    |  .      |   |      .
tnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp.slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanl

NhTFTWSVIGVPKSPEDLIAfmgeVETCYTETEG----EGGKPIILHCSAGVGRTGTFCVIFSAIREfTAHNGIINIPRMVRTLRQQRKYMVQKKV
.  .  |.|  |. |.  .      | |.|  .         | ..|||||..|... . .  .|   . .   ...  ..  |...|   .| ..
k.elrvslikwpnwpdrgvp....dekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidk.ldrglkvdaeevktellksraiciqtel
0042113 (Phosphotyrosine protein) phosphatases II 1196-1388 3.9e-47 156.1 In-house 48-232 (245) alignment 
Range on Protein: 1196-1388
Range on HMM: 48-232/245.0
TPMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIdeGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVIN
  ..| ||||||| ..|..||| |.||... .|||||.|.| .. ||.||||   |..  .| ..| |.| .. .....|.......  . .  |.|.  
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

HTFTwsVIGVPKSPEDLIAFMGEVETCYTEtegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHnGIINIPRMVRTLRQQRKYMVQKKVIL
. .     ||| ..|.|. |. .|.... |    ...|.. ||||||||||||.... ... . .. . ....  |. ||.||  .||    .
lpwp..dhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfiaaylmleqleke.lgvsleeavkelrsqRpgavqtpsqy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1196-1386 6.9e-25 82.3 In-house 90-276 (305) alignment 
Range on Protein: 1196-1386
Range on HMM: 90-276/305.0
TPMSP--PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPgwIRRVMHIQHNDVSTVYLVC--
 || |   ||..|||.  |. .|| || ...   |||| | ||  |||| ||||.  |    .    |  .   | |  . |   ||   .   |     
cpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskp..merdaeiqitllnltysgdqk

HVIN--HTFTWSVIGVPKSPEDLIAFMGEVetcytetEGeGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKKV
  .   .   |   |||      . ..  .        |    ||..|||||.|||||   |   . . .  .    .| .|..||.|| . .|. |
msvrhlqwtewpdrgvppckltslellsai.......rg.skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1196-1384 8.8e-16 52.5 In-house 83-272 (305) alignment 
Range on Protein: 1196-1384
Range on HMM: 83-272/305.0
TPMSP-PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPM--RVSLKSLTSspGWIRRVMHIQHNDVSTVYLVCH
||  |  || || |.  | |||| | ....   | || . .|    ||..|.. .....  |     ..|.|  .|  . .. . . . .   || ..  
tptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfess..vtlkfrkdakakvtetvlvieg

----V----INHTFTWSVIGVPKSPEDLIAFMGEVETCytetEGeggkPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQK
    .      |   |   ||| .   .. .. .  .      |    ||..|||||.||||.  ..   . .. | . | .  .... .|.||.  .| 
pgekarkvthyhwidwpdrgvpaadlailellekarps....kg....pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqt
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1196-1383 6.4e-15 49.4 In-house 85-269 (302) alignment 
Range on Protein: 1196-1383
Range on HMM: 85-269/302.0
TP-MSPPFIATQGPIASTL---ADFWLMVWEQQSPVIVMLTKEVEGNKlKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWI-RRVMHIQHNDVSTVYLv
 | .... | .| |. ..    ..|| ||....   .|.| .| | .|   ....|   |  . .| |.|  .   .. .   | |. .  ...|   | 
vPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvl.

CHVINHTfTWSVIGVPKSPEDLIAFMGEVetcYtETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHnGIINIPRMVRTLRQQRKYMVQ
. |  .|  | .  ||..  .||. . .|   . . . .. .....    |.|| |.| . . |. . ...    ||  .|...|.||  .|.
anvyvlt.nWkqkkvpvkyaeliktaakv...f.akkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravd
0046845 (Phosphotyrosine protein) phosphatases II 1197-1386 2e-54 180.3 In-house 74-261 (284) alignment 
Range on Protein: 1197-1386
Range on HMM: 74-261/284.0
PMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDeGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVInH
  .. |||||||  .|..||| |||||...||||||..|| .. ||.|||| . |..  .|...| |.| .  .....|.. .......  .. .... |
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthf.h

TFTWSVIGVPKSPEDLIAFMGEVETCYTEteGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNG--IINIPRMVRTLRQQRKYMVQKKV
 ..|   ||| |||||..|. .|......   .||.||. ||||||||||||...  ... . ...    .... .|. ||.|| .|||   
ytswpdhgvppspedlleflrlvrellen..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
0037934 (Phosphotyrosine protein) phosphatases II 1197-1388 2.1e-45 150.5 In-house 41-231 (243) alignment 
Range on Protein: 1197-1388
Range on HMM: 41-231/243.0
PMSPPFIATQGPIASTLAD----FWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPideGHTnLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYlVCH
.. | .||||||  .|..|    || |.||... ||||||..|| ...||.||||   | .  .|...| |.| .. .... |...... | . ..   .
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.tygdftvtllseehlddytvrtlllenldlddlt.rlv

VINHTFTWSVIGVPKSPEDLIAFMGEVETCYTE-----TEGEGgKPIILHCSAGVGRTGTFCVIFSAIREFtahnGiINIPRMVRTLRQQRKY-MVQKKV
.  | . |   ||| |||||..|. || ... |     .. .| .|...|||||||||||.....  .. .    | ...   |..||.|| . .||   
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg.gpvlVHCsaGvgRtGtliaaylmllll....g.vdleeavkllreqRpgkavqtps

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subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1197-1385 1.1e-42 141.3 In-house 96-276 (298) alignment 
Range on Protein: 1197-1385
Range on HMM: 96-276/298.0
PMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPidEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinH
  ...|||||.|. .|..||| ||.|... .|||||. .| .|.|.|.|||  . ... .| ..|||.|  .    | | ..........   |...  |
kgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP..degketygeitvsllskeefadlivrklkvskkkeekerevrql..h

TFTWSVIGVPKSPEDLIAFMGEVETcYTETegEGGKPIILHCSAGVGRTGTFCVIFSAIREFtAHNGIINIPRMVRTLRQQRKYMVQKK
 ..|.  |||.  . ..... .|.. ...    | ||.|..|||||||.|||..| | .     ..  . . ..|..||..|  .|| .
ftsWpdkgvpenatsvldllrkvra.sqqq..agnkpvivqCsaGvgRsGtfiaidsvlerv.kkeqvvDvfqvvkvlRkkrpgavqte
0036282 (Phosphotyrosine protein) phosphatases II 1197-1385 1.2e-30 101.9 In-house 14-156 (174) alignment 
Range on Protein: 1197-1385
Range on HMM: 14-156/174.0
PMSPPFIATQGPIAstladFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIdeghtnlfgpmrvslksltsspgwirrvmhiqhndVSTVYLVCHVINH
  .| .||.||| |     || |..|... ..|||..|.| .. ||..|||                                     .. .   ..  .
yitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................lredlerlgiqyl

TFTWSVIGVPKSPEdLIAFMGEVETCYTEtegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTahNGIINIPRMVRTLRQQRKYMVQKK
 . |   ||| ... |. |. .||... |    .|.|.. |||||||||||.....  .|     .. ... ..||.||.|| .|||  
ylpwpDhgvpdlsi.llefvkfveealse...dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtp
0049260 (Phosphotyrosine protein) phosphatases II 1197-1392 1.5e-27 91.6 In-house 6-143 (152) alignment 
Range on Protein: 1197-1392
Range on HMM: 6-143/152.0
PMSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWpideghtnlfgpmrvslksltsspgwirrvmhiqhndvstvylvchvINH
 |. .|||||||   |||||| |..|..  .|||||...| .||||.||.                                                 .
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qyl

TFTWSVIGVPKSPEDLIAFMGEVETCytetEGEGGKPIILHCSAGVGRTGTFCVIFSAIreftahnGIINIPRMVRTLRQQRKYMVQKKVILQKLY
 . |   |||.... |. ..  .| .      . |.|.. |||||||||||.....  .         ...   |. .|..|...|. .  |. ||
hlpwpDhgvpdlsqlllflllfiekl....aldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
0050432 (Phosphotyrosine protein) phosphatases II 1198-1387 9.7e-57 188.0 In-house 106-287 (308) alignment 
Range on Protein: 1198-1387
Range on HMM: 106-287/308.0
MSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEG-HTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinH
 .  |||||||  .|..||| |||||...|||||||.|| .. ||.|||| ..| ..  .|...| |.| .. .....|........ . .  | |   |
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthf..h

TFTWSVIGVPKSPEDLIAFMGEVETCYtetegeGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHnGIINIPRMVRTLRQQRKYMVQKKVI
  .|   ||| |||.|..|. .|....      .|.||. ||||||||||||...  ... . .. | .... .|..||.|| .||| .  
ytnWpdhgvPpspeilldflelvrksl......pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeq
0051299 (Phosphotyrosine protein) phosphatases II 1198-1385 9.1e-54 178.2 In-house 90-272 (288) alignment 
Range on Protein: 1198-1385
Range on HMM: 90-272/288.0
MSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIdeGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHND----VSTVYLVCHV
..  |||||||  .|..||| |||||...|||||||.|| .. ||.||||   |..  .|...| |.| .. .... |.......|     .... | | 
lkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthf

inHTFTWSVIGVPKSPEDLIAFMGEVETCYTetegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHnGIINIPRMVRTLRQQRKYMVQKK
  | ..|   ||| |||.|..|. .| ...      ||.|.. ||||||||||||.... ... . .. | ......|..||.|| .|||  
..hytnwpdhgvpdspellldflrlvrkala....sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtp
0047943 (Phosphotyrosine protein) phosphatases II 1198-1386 6e-53 175.4 In-house 75-259 (273) alignment 
Range on Protein: 1198-1386
Range on HMM: 75-259/273.0
MSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGH-TNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinH
... |||||||  .|..||| |||||...||||||..|| .. ||.|||| ..|. .  .|...| |.| .. .... |.. ..... . .. |.|.  |
lkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthf..h

TFTWSVIGVPKSPEDLIAFMGEVETCYTETEGEggKPIILHCSAGVGRTGTFCVIFSAIREFTAHnGIINIPRMVRTLRQQRKYMVQKKV
 ..|   ||| |.|.|. |. .|.... .. ..  .|.. ||||||||||||.... ... . .. | ....  |. ||.|| .|||   
ytgwpdhgvppslesllefielvrkalealpsn..gpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpe
0045450 (Phosphotyrosine protein) phosphatases II 1198-1389 1.3e-50 168.3 In-house 105-294 (307) alignment 
Range on Protein: 1198-1389
Range on HMM: 105-294/307.0
MSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDeGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVINHt
 .  |||||||  .|..||| |.|||.. ||||||..|| .. ||.|||| . |..  .|...| |.| .  .|...|.......| .   . .... . 
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy.

FTWSVIGVPKSPEDLIAFMGEVETCYTETegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGI--INIPRMVRTLRQQRKYMVQKKVILQ
 .|   |||.|.|.|..|. ||.... |.   .|.|.. ||||||||||||.... ..| . ... .  ....  |..||.||  .||    ..
tgwpdhgvppsfeelldfieevrkaleel..pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyr
DSPc_SM00195 1198-1385 1.3e-49 164.3 In-house 67-248 (263) alignment 
Range on Protein: 1198-1385
Range on HMM: 67-248/263.0
MSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSP-GWIRRVMHIQHNDVSTVYLVCHVinH
 .  .||||||  ||..||| ||||.....|||||.|.| .| ||..||| ..|... || ..| |.. .. .  .|.|........ .. . | ..  .
kkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy..q

TFTWSVIGVPKSPEDLIAFMGEVETCYTETegegGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGiINIPRMVRTLRQQRKYMVQKK
  .|   |||.|........ .|.... ..     .||. ||||||||||||..| ..........  ..|  .|. ||.||  |||..
yknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtl
PTPc_SM00194 1198-1385 1.3e-49 164.3 In-house 67-248 (263) alignment 
Range on Protein: 1198-1385
Range on HMM: 67-248/263.0
MSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSP-GWIRRVMHIQHNDVSTVYLVCHVinH
 .  .||||||  ||..||| ||||.....|||||.|.| .| ||..||| ..|... || ..| |.. .. .  .|.|........ .. . | ..  .
kkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy..q

TFTWSVIGVPKSPEDLIAFMGEVETCYTETegegGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGiINIPRMVRTLRQQRKYMVQKK
  .|   |||.|........ .|.... ..     .||. ||||||||||||..| ..........  ..|  .|. ||.||  |||..
yknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtl
0043336 (Phosphotyrosine protein) phosphatases II 1198-1388 1.5e-48 161.1 In-house 86-266 (278) alignment 
Range on Protein: 1198-1388
Range on HMM: 86-266/278.0
MSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPideGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVINht
... |||||||  .|..||| ||||.....|||||..|| .. ||.||||   |..  .|...| |.. .. .....|.... ..  . .. |.|.    
vprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhy..

FTWSVIGVPKSPEDLIAFMGEVETCYTetegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNgIINIPRMVRTLRQQRKYMVQKKVIL
. |   ||| |...|. |. .| ...       ..|.. ||||||||||||.... ... .  .   ....  |..||.||  .||    .
lgwpdhgvpeslsllldflkavreale....dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1198-1384 1e-25 85.0 In-house 92-268 (290) alignment 
Range on Protein: 1198-1384
Range on HMM: 92-268/290.0
MSPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKS-LTSSPGWIRRVMHIQHNDVSTVYLVCHVinH
. ..|| |||....|  |.| || ...  .|||| . .|  | ||.||.|  ||..  || . |      .     |.... ... |    . . |.  .
lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhl..k

TFTWSVIGVPKSPEDLIAFMGEVETCytetEGeggkPIILHCSAGVGRTGTFCVIFSAIREFTAHNgIINIPRMVRTLRQQRKYMVQK
. .|    |..|   |.  .  . .      |    |...|||||.||||||  |  ... ..     ...  .||.||. |   || 
ikswpdksvalstlallrtlrilrka....sG....pvvvhcsaGiGrtGtfvaievglqilldGk.eldlldlvralrnsrlnsvqv
0036941 (Phosphotyrosine protein) phosphatases II 1199-1385 9.9e-55 181.3 In-house 77-263 (297) alignment 
Range on Protein: 1199-1385
Range on HMM: 77-263/297.0
SPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTS--SPGWIRRVMHIQHNDVSTVYLVCHviNH
.  |||||||  .|..||| |||||...||||||..|| .. ||.|||| .||..  .|...| |.| ..  ......|........ . .. | |   |
krkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvth..fh

TFTWSVIGVPKSPEDLIAFMGEVETCYTETegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTA--HNGIINIPRMVRTLRQQRKYMVQKK
 ..|   ||| ||..|..|. .|.... ..   .|.|.. ||||||||.|||.... ... .    ..| ..|. .|..||.||  .||  
ytgwpdhgvpespaslldfielvrkvlkll..psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
0040438 (Phosphotyrosine protein) phosphatases II 1199-1388 1.4e-52 174.3 In-house 85-265 (317) alignment 
Range on Protein: 1199-1388
Range on HMM: 85-265/317.0
SPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIdeGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinHTF
.. |||||||  .|..||| |||||.. ||||||...| .. ||.||||   |.|  .|...| |.| .  .|.. |........ |..  | |   |  
krkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthf..hyt

TWSVIGVPKSPEDLIAFMGEVETCYTetegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNgIINIPRMVRTLRQQRKYMVQKKVIL
.|   |||.||..|..|. .|....     ..|.|.. ||||||||||||.... ... .  ..  ....  |..||.|| ..||    .
gWpdhgvppspdllldfleavreale....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqy
0039614 (Phosphotyrosine protein) phosphatases II 1199-1389 2e-50 167.3 In-house 100-279 (297) alignment 
Range on Protein: 1199-1389
Range on HMM: 100-279/297.0
SPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKlKCHQYWPIDEGhtnLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVStvylVCHVINHTF
.. |||||||  .|..||| |||||...|||||||.|| .. ||.|||| ..|    .|...| |.. .  .|...|......|. |      .   . .
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges....rtvthfqyt

TWSVIGVPKSPEDLIAFMGEVETCYTETegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHnGIINIPRMVRTLRQQRKYMVQKKVILQ
 |   ||| |.|.|. |. .|.... |.  ..|.|.. ||||||||||||.... ... .  . | ....  |..||.|| ..||    ..
gwpdhgvppslellleflelvrealael..pkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyr
Y_phosphatase Protein-tyrosine phosphatase 1199-1385 4.1e-50 165.7 Pfam-A 41-223 (235) alignment 
Range on Protein: 1199-1385
Range on HMM: 41-223/235.0
SPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLK-SLT-SSPGWIRRVMHIQHNDVST-VYLVcHVIN
.  |||||||. ||..||| |||.... ||||||...| .. ||.|||| .|. .. .| ..| || . .  . ... |........ ..    | ... 
kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrev.kqlh

HTfTWSVIGVPKSPEDLIAFMGEVETCYteteGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGiINIPRMVRTLRQQRKYMVQKK
.| .|   |||.||..|. .. .||.       .  .|.. ||||||||||||...  ......|..  ...  .|..||.||  |||. 
yt.nWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.vdvlqivkelRkqRpgmvqsl
Y_phosphatase Protein-tyrosine phosphatase 1199-1385 4.1e-50 165.7 In-house 41-223 (235) alignment 
Range on Protein: 1199-1385
Range on HMM: 41-223/235.0
SPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLK-SLT-SSPGWIRRVMHIQHNDVST-VYLVcHVIN
.  |||||||. ||..||| |||.... ||||||...| .. ||.|||| .|. .. .| ..| || . .  . ... |........ ..    | ... 
kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrev.kqlh

HTfTWSVIGVPKSPEDLIAFMGEVETCYteteGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGiINIPRMVRTLRQQRKYMVQKK
.| .|   |||.||..|. .. .||.       .  .|.. ||||||||||||...  ......|..  ...  .|..||.||  |||. 
yt.nWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.vdvlqivkelRkqRpgmvqsl
0045098 (Phosphotyrosine protein) phosphatases II 1199-1390 5.6e-48 159.1 In-house 63-263 (278) alignment 
Range on Protein: 1199-1390
Range on HMM: 63-263/278.0
SPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPiDeGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVINHT-
.. |||||||  ||.|||| |.||....||||||..||... ||.|||| . |..  .|...| |.| .  . .. |......  |   .| .. ..|  
pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlh

F-TWSVIGVPKSP--EDLIAFMGEVETCYTETEGE---------GGKPIILHCSAGVGRTGTFCVIFSAIREFtahNGIINIPRMVRTLRQQRKY-MVQK
. .|   ||| .|    .. .. ... .. .  .          .|.|.. |||||||||||.....  .. .   .| ....  |..||.|| . .|| 
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqn

KVILQK
.  .. 
leqyrf
subfamily_PTPN6_pd Subfamily PTPN6 1199-1392 3.3e-45 149.4 In-house 97-290 (306) alignment 
Range on Protein: 1199-1392
Range on HMM: 97-290/306.0
SPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNlFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVylVCHVIN-HT
.  .||||| . .|..||| |||...| ||||.||||| .| || .|||  | ... .| ..|.  | .|   .| | ....... ..     .|.. | 
dksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkke..erevfqyhf

FTWSVIGVPKSPEDLIAFMGEVETCYTETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTA--HNGIINIPRMVRTLRQQRKYMVQKKVILQKLY
 .|   ||||.|. ...|. .|.. . |.| .   ||. |||||.|||||| ||   ..  .    .  |.| ..|...|.||. .|| .   . .|
ksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvy
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1199-1384 3.7e-40 132.5 In-house 85-261 (515) alignment 
Range on Protein: 1199-1384
Range on HMM: 85-261/515.0
SPPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVylvchVIN-HT
   .||.|||  ... ||| .|....   |.|.||  ||.| || .|||   | .  || ..|.| || .  | |.| ... ..| |       |   | 
dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrt.....vtqfhf

FTWSVIGVPKSPEDLIAFMGEVETcyteTEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFtAHNGIINIPRMVRTLRQQRKYMVQK
  |   ||||    |. .. || .     .|.   |.|.|||||||||| .. | | . .  .   .... ..|. .||.| |.|| 
teWPdkGvpkhtssllklikevka....dhgqythpliihcsaGvGrtGvvisidsvvaha.kttrmvdvfnfvtnirqkrpylvqt
0051082 (Phosphotyrosine protein) phosphatases II 1199-1388 9.1e-23 76.0 In-house 12-142 (151) alignment 
Range on Protein: 1199-1388
Range on HMM: 12-142/151.0
SPPFIATQGPiastLADFWLMVWEQQSPVIVMLTKEVEGNklKCHQYWPIDEghtnlfgpmrvslksltsspgwirrvmhiqhndvstvylVCHVINHTF
 . .....||    ||||. ...|..  .||.|..|.| .  .|..|.|  .                                       . ..  . .
tgglyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.......................................ievlhipil

TWSVIGVPKSPEDLIAFMGEVETcytetegEGGKPIILHCSAGVGRTGTFCVIFSAIREftahngiINIPRMVRTLRQQRKYMVQKKVIL
 |.. |.| |.. ...|. ...         ...|.. |||||.|||||.....  ..        ...   .. .|..| ..|| .   
dwpdpglplsfdavleflellld.......kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqf
subfamily_PTPN12_pd Subfamily PTPN12 1200-1385 2.4e-39 129.9 In-house 83-263 (290) alignment 
Range on Protein: 1200-1385
Range on HMM: 83-263/290.0
PPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSP-GWIRRVMHIQHNDVSTVYLVChvinHTF
  .||.|||.. || ||| |.||..  ..||. .||| .| ||..|||   ...  ||...|.|..      ... | ....... | .        |  
leyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqf....hYt

TWSVIGVPKSPEDLIAFMGEVETCYTetegEGGKPIILHCSAGVGRTGTFCVIfSAIREFTAHNGI---INIPRMVRTLRQQRKYMVQKK
 |   |||.|...|.... .|..  .    .  .|...||||||||||| ..|   .||   .. |   ...  .|..||.||. .|| |
aWPDhgvPssaksllelielvrelqe....sedaPlvvhCsaGvGrtGtiiai.dyvrellkaekipeeldvfdlvlelrkqraalvqtk
0046846 (Phosphotyrosine protein) phosphatases II 1200-1384 3.9e-30 100.3 In-house 23-158 (176) alignment 
Range on Protein: 1200-1384
Range on HMM: 23-158/176.0
PPFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNlfgpmrvslksltsspgwirrvmhiqhndvstvylvchvINHTFT
. .||||||. .|||||. |..|..  ..|.||.||| ..|||..|||. |..                                           . . 
srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................................qylhlp

WSVIGVPKSpEDLIAFMGEVETCYTEtegegGKPIILHCSAGVGRTGTFCVIFsaireFTAHNGIINIPRMVRTLRQQRK-YMVQK
|   ||| . |.|. .. .......|     |.|.. |||||.|||||.....        ..  ...   ....|.||  ..|| 
wpDhgvpdl.elllellefirealke.....ggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavqt
0041856 (Phosphotyrosine protein) phosphatases II 1200-1384 1.9e-27 91.4 In-house 34-156 (182) alignment 
Range on Protein: 1200-1384
Range on HMM: 34-156/182.0
PPFIATQGPIASTLADFWLMVWEQQSPVIVMLTkevegnklkCHQYWPideghtnlfgpmrvslksltsspgwirrvmhiqhndvsTVYLVCHVINHTFT
  |||||||  ||.|||. |..|..  .||.||         ...|||                                      . .    .  . . 
trfiatqgpllstvadflrmlkelgittivnlt.........eelywp......................................ellerlgiqylylp

WSVIGVPKsPEDLIAFMGEVETcytetegeGGKPIILHCSAGVGRTGTFCVIFSAIREftahnGiINIPRMVRTLRQQRKYMVQK
|   |||  ...|..|. ||.          |.|.. |||||||||||.....  ..      | ....  |...|..|  ||. 
wpDhgvpd.ldelldfieevle........eggpvlVHCsaGvgRtgtlvaaylmkkl.....g.vsleeavklvrsrRpgmvit
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1200-1248 1.3e-13 45.4 In-house 102-152 (350) alignment 
Range on Protein: 1200-1248
Range on HMM: 102-152/350.0
PP--FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPI
|   .||||.|. ||. ||. .. . . .||..||..|| |  ||..||. 
pdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqe
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1201-1385 5.2e-50 165.3 In-house 90-266 (318) alignment 
Range on Protein: 1201-1385
Range on HMM: 90-266/318.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEghTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinHTFTW
 .||.|.|.. |. ||| |||||.| ||||||.|.|  | |.|.||| ..  .. .| ..| ||. ...  .. | ......... .  |     |  .|
ayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqy..hytsW

SVIGVPKSPEDLIAFMGEVETCYTEtegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAhNGIINIPRMVRTLRQQRKYMVQKK
.  |||.|. .|......|..  ..   .| .||. ||||||||||.|... . ..   | ......  .|..||.||. ||| .
pdegvpesgaslldlvrqvskaqqk...sgagpivvhCsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqte
subfamily_PTPRB_pd Subfamily PTPRB 1201-1385 2.7e-49 162.8 In-house 95-271 (293) alignment 
Range on Protein: 1201-1385
Range on HMM: 95-271/293.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTnLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVylVCHVinHTFTW
 |||||||. .|. ||| ||||..| .|||||. ||. | ||..||| ||  . |.| ..|.|.. ..   |. | ..|.... ..   | .   |  .|
efiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiekekeerk..vrqy..hftsW

SVIGVPKSPEDLIAFMGEVETCYTETEgeGGKPIILHCSAGVGRTGTFCVIFSAIREFTAhNGIINIPRMVRTLRQQRKYMVQKK
.  |||.... |..|. .|..  ..|.    .||. ||||||||||||  .   ... .  . ...|  .|  ||..|...|| .
pdhgvPektktlldfvrtvreaiekta..skrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqte
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1201-1388 4e-49 162.2 In-house 85-265 (281) alignment 
Range on Protein: 1201-1388
Range on HMM: 85-265/281.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPiDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVcHvINHTfTW
 .||||||. ..|..|| |||||.  .|||.|.|.|..|||||.||| |. ..  .| ..|. .. .... .|.|........  |. .. . ...| .|
eyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreve.q.layt.aW

SVIGVPKSPEDLIAFMGEVETCYTETEGeggKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKKVIL
   |||.....|. |  ||. . .. .     |...|||||||||||.  .  .... .|..  ...  .|. ||..|..|||  |  
PdhGvPattkellefrkevlkltekktk...aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1201-1385 3.1e-46 152.9 In-house 90-269 (305) alignment 
Range on Protein: 1201-1385
Range on HMM: 90-269/305.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVInHTFTW
 .|..|||. .|.|||| ...| .  .|||||| |||.| ||.||||  ..... ||.. | ||| .. ...| | ..|  .| .    .     .  .|
kyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqy.qltdW

SVIGVPKSPEDLIAFMGEVETCYTEtegEGGKPIILHCSAGVGRTGTFCVIFSAIREfTAHNGIINIPRMVRTLRQQRKYMVQKK
   |||...  |. .. .|.  . .   . |.|.. ||||||||||.|...  |.     . ..... .....||..| .|||..
PdhGvpqfatsllslikrvqkdqkk...dkgvpllVhCsagvgRtGvfiavdialer.lkkEevvdvfevlkqlRskrmkmvqtl
subfamily_PTPN3_pd Subfamily PTPN3 1201-1385 5.7e-44 145.1 In-house 85-261 (280) alignment 
Range on Protein: 1201-1385
Range on HMM: 85-261/280.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIdEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinHTFTW
 .||||||.|.| .||| |||||.| .|||||  ||  . |||||||  ....  .| ..| ...  ..  .. | . ..... .    . ..      |
ryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilql..qylaW

SVIGVPKSPEDLIAFMGEVETCYTETEgeggKPIILHCSAGVGRTGTFCVIFSAIReFTAHNGIINIPRMVRTLRQQRKYMVQKK
.  |||....|.. |. .|... . .|    .|...|||||.|||| . ..  |.   . ..  .... .|||.|.||. .|| .
pdhgvPddsadflefvervrklrsgke....ePvvvhCsaGigrtGvlilletala.lieaaepvypldivrtmrdqramlvqta
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1201-1385 7.1e-44 145.0 In-house 91-265 (288) alignment 
Range on Protein: 1201-1385
Range on HMM: 91-265/288.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNlFGPMRVSLKSLTSSPGWIRRVMHIQhndV-STVYLVCHvInHTFT
 .||||||.|.|. ||| .|.|...  |||||. |||.| ||..||| .. ..| .| . | |..      .. | . ..      | . . .   .  .
kyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpkn.yGsvtvtlveskeledfvlrkllle...kkkteleitq.y.qyla

WSVIGVPKSPEDLIAFMGEVETCYTETegegGKPIILHCSAGVGRTGTFCVIFSAIREFTAhNGIINIPRMVRTLRQQRKYMVQKK
|.  |||.| ..|....  |..  ..      .||| |||||||||||| ..  .| .  . .  |..  .|  ||.||. .||..
WpdhgvPeskapllellrqvkvanqad....tgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1201-1385 3.1e-42 139.8 In-house 92-269 (319) alignment 
Range on Protein: 1201-1385
Range on HMM: 92-269/319.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPidEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQH--NDVSTvylvCHVINHTF
 |||||.|.. |. ||| ||||..| ..||||| ||  |.|...|||  | . . .| . | |..     ..| | .....  ..| |     .| ....
kfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkkssevet....Revkhfqy

T-WSVIGVPKSPEDLIAFMGEVETCYtetEGEGGKPIILHCSAGVGRTGTFCVIFSAIREfTAHNGIINIPRMVRTLRQQRKYMVQKK
| |.  .||..   |........      |..  .||. ||||||||||||.|.. ..     ..|....  .|..|| ||. |||..
teWpdhdvPekatslldllkrirksr...ektqsgPivvhCsaGvGRtGtfivldamler.vkeegvlDvfstvsrlRtqRnimvqrp
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1201-1385 7.8e-41 135.0 In-house 74-254 (274) alignment 
Range on Protein: 1201-1385
Range on HMM: 74-254/274.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGH--TNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVylVCHVINHtf
 ..|||||...|.||||.|.......|||||||  | |. ||..|.| .|.   .. .| . .  .. ..  ..  | . ...   .    | |      
ayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers..vkhywyt..

TWSVIGVPKSPEDLIAFMGEVETCYTETEGEGGkPIILHCSAGVGRTGTFCVIFSAIREFTaHNGIINIPRMVRTLRQQRKYMVQKK
 |    .|.... |. .. |||.  .|.. . . |...|||||.|||| |  |  |.|..  ....... ..|  ||..|  |||..
dWPdhksPddantlldlvleveesreeenakla.pvvvhCsaGiGrtGcfiaisiavrqlr.eeivvdvlkivcnlrldrGGmvqts
subfamily_PTPRK_pd Subfamily PTPRK 1201-1384 4.4e-40 132.4 In-house 87-262 (314) alignment 
Range on Protein: 1201-1384
Range on HMM: 87-262/314.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPiDEGHTnlFGPMRVSLKSLTSSPGWIRRVMHIQH--NDVSTVYLVCHVinHTF
 ||.||||. .|..||| .|.....  |||||. ||  ..|| .||| .....  .|...| | . .     . |.. ...    .. . .| ..  .  
afivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP.edtev..ygdikvelvetellaelvvrifrveklargqeeirevrqf..qfl

TWSVIGVPKSPEDLIAFMGEVETCYTETEGeggkPIILHCSAGVGRTGTFCVIfSAIREFTAHNGIINIPRMVRTLRQQRKYMVQK
.|.  .||.| . |.... .|..   |..|    .|..||||| ||||||..| . . .   ..|....  .|.|||...  ||. 
gWpdhdvPvsatgllklvrrvkksqeeeaG....rivvhCsaGaGrtGtfiai.divldmieregvvdvfnavktlrsrkvnmvet
subfamily_Ptp69D_pd Subfamily Ptp69D 1201-1384 1e-39 131.5 In-house 92-271 (307) alignment 
Range on Protein: 1201-1384
Range on HMM: 92-271/307.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDegHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHND--VSTVYLVCHVINHTF
 ||| |.|. .|. ||| |..||.. .||||... | |. ||..||||.  ..  .| . | | |  . . .|.| ... ...  .. |    .|. . .
kfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhy

-TWSVIGVPKSPEDLIAFMGEVETCYTETegegGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNgIINIPRMVRTLRQQRKYMVQK
 .|    ||.... |. .. .|.  |         ||..||||||||.|.|  . | . .  | .  ..|  .|. ||.||. .||.
tgWkDskvPevargllklieqvrelykln....rsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqs
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1201-1385 4.7e-39 129.1 In-house 53-228 (250) alignment 
Range on Protein: 1201-1385
Range on HMM: 53-228/250.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLkCHQYWPIDegHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinHTFTW
 |||||||. .|. ||| ||.|..| .|||||. .| .|  .|||||..  ... .| ..|||.|      .. |.. . ..  .   .| ..  | ..|
afiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..kaekyGdvtvsllskeefadytkrklklskakkaderivrql..hfvvW

SVIGVPKSPEDLIAFMGEVETCYTETegeGGKPIILHCSAGVGRTGTFCVIFSAIREfTAHNGIINIPRMVRTLRQQRKYMVQKK
   |||.  .  .... .|..   ..   | .|.|..|||||||.|.|..| . .     .. .... .....||..|  .|. .
PdkgvPevatavLellkkvqasqqqa...gnaPvivqCsaGvgrsGafiaidavler.lkkekvvdvfkvikvlrkdrphavesl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1201-1385 1.1e-33 111.4 In-house 46-225 (237) alignment 
Range on Protein: 1201-1385
Range on HMM: 46-225/237.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEgHTNLFGPMRVSLKSLTSSPGWIRRVMHI-QHNDVSTVYLVcHVINHTfT
 .||.|||. |.  ||| |||...  ||||||  .|||.||||.|||  .   . .| . ||||       .  | . . ..  .  | |. |  . | .
kyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaaygvltvslkkkeefsdytvrslllskrltlkevrli.hqyqft.s

WSVIGVPKSPEDLIAFMGEVETCYTETegEGGKPIILHCSAGVGRTGTFCVIFSAIREfTAHNGIINIPRMVRTLRQQRKYMVQKK
|   |||.    |. |  ..             | |.|||||||||| | || . .|. .  . ...|   | .. ..| |..| |
wpdrgvpqqtaallrfrkniinrsphv..sesgpwiihcsagvgrtgiflvidamlrq.akekkvvdiynyvysieedrpyiiqtk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1201-1384 2.8e-29 97.0 In-house 53-226 (239) alignment 
Range on Protein: 1201-1384
Range on HMM: 53-226/239.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPideGHTNLFGPMRVSLKSLTSSPGWIRRVMHI-QHNDVSTVYLVchvINHTFT
 .||||| .. .  ||| |.|...  ||||||  .|| | |||||||     |. .  .||.|.       .| | . . |  .    |.      |   
ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvy...qyhftv

WSVIGVPKSPEdliAFMGeVETCYTETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTaHNGIINIPRMVRTLRQQRKYMVQK
|   |||.      | .| .    |.    | .| ..||||||||||.| || . .|.   ..  ..|   |...|..| .||| 
wpdkgvpqyat...avlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak.kqktvdifnyvkairedrphmvqt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1201-1384 2.8e-29 97.0 In-house 52-225 (239) alignment 
Range on Protein: 1201-1384
Range on HMM: 52-225/239.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPideGHTNLFGPMRVSLKSLTSSPGWIRRVMHI-QHNDVSTVYLVchvINHTFT
 .||||| .. .  ||| |.|...  ||||||  .|| | |||||||     |. .  .||.|.       .| | . . |  .    |.      |   
ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvy...qyhftv

WSVIGVPKSPEdliAFMGeVETCYTETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTaHNGIINIPRMVRTLRQQRKYMVQK
|   |||.      | .| .    |.    | .| ..||||||||||.| || . .|.   ..  ..|   |...|..| .||| 
wpdkgvpqyat...avlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak.kqktvdifnyvkairedrphmvqt
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1201-1386 1.5e-25 84.9 In-house 83-264 (307) alignment 
Range on Protein: 1201-1386
Range on HMM: 83-264/307.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGP--MRVSLKSLTSSpgwiRRVMHIQHNDVSTVYLV----CHVI
 ||..|||  .|  .|| |. ...   ..|| | .|  |.||.||||..|| .. ||     .|.. | .     .     .  .|.|. ..    .  |
kficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgak....klapdedlinvttlkvdwaqksrti

NHT--FTWSVIGVPKSPEDLIAFMgevETCYTETegeggKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKKV
.|     |   |||.     | ..   |.   .|      |...||||||||.||   |        |     .. ..|. ||.||.| .|...
qhlqwenwpdrgvpqinltainll...eavrydt.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqtea
0044763 (Phosphotyrosine protein) phosphatases II 1201-1391 1.2e-22 75.8 In-house 29-163 (178) alignment 
Range on Protein: 1201-1391
Range on HMM: 29-163/178.0
PFIATQGPIastlADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGhtnlfgpmrvslksltsspgwirrvmhiqhndvstvylvchVINHTFTW
 ..... |     ||.. ...|.   .||.||.|.|...|||..||| ..|                                         .  . . .
glylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.........................................iqylhipi

SVIGVPKSPEDLIAFMGEVETCYTetegEGGKPIILHCSAGVGRTGTFCVIFSAIREftahnGIiNIPRMVRTLRQQRKyMVQKKVILQKL
.  ||| ..| . .|.  .|...     | |.|.. ||||||||.||.....  ..      |. ...  .. .|..|  .|.    |. |
pDhgvpdllehflefvefieeald....ekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl.sleeaielvrerRp.ivpnpgqlrqL
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1201-1386 3.4e-22 73.6 In-house 91-268 (301) alignment 
Range on Protein: 1201-1386
Range on HMM: 91-268/301.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSS--PGWIRRVmhIQHNDVSTVYlVCHVINH-T
 |||||||. .|  ||| |.   .   ||||...|| .. ||..| |.. ...   |  .. .|.  .      ..|   .. .| .  .   . . |  
rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrt..levedstgkf.atrtvthyq

-FTWSVIGVPKSPEDLIAFMGEVEtcytetegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAhNGIINIPRMVRTLRQQRKYMVQKKV
  .|.  |||||  .|  .|  |         .  |||..|||||.||. .|       ||  | .  |.. . .. ||..|   ||.. 
ysewtdrgvPkshaelfdlmelvk........ksekPivvhcsaGiGrsvafigteylarevea.dptieltealkhlrehrwngvqtns
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1201-1384 4.8e-21 69.9 In-house 77-280 (297) alignment 
Range on Protein: 1201-1384
Range on HMM: 77-280/297.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPgWIR-RVMHIQHNDVSTVYLVCHVinHTFT
 .| .|||. .|. ||| .|.||.  ||||..|  |. . ||  |||  ..     | . |   | ||   . |  .  .|    |    | ||    ..
kyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhv..qfls

WSVIGVPKSPEDLIAF--------------MGEVE--T--CYT-----ETEGEGGKPIILHCSAGVGRTGTfCVIFSAIREFTAHNGIINIPRMVRTLRQ
|   |||   |||  |              .. ||  |   .      ..|     ....||||||||.|   |   .| . . .. | ..  ... ||.
wpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGv.vvlsdvilaklrkkripdvaailsilre

QRKYMVQK
||  .|| 
qrarlvqt
0049772 (Phosphotyrosine protein) phosphatases II 1201-1382 2.3e-20 69.0 In-house 85-263 (314) alignment 
Range on Protein: 1201-1382
Range on HMM: 85-263/314.0
PFIATQGPIASTLADF----------WLMV--WEQQSPVIVM---------------------LTKEVEGNklkcHQYWPIDEGHTNlfgpmrvslkslt
 |||||||   |. ||          | ||  ..... .|||                     |..  ...     .... |  . .             
kfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk.............

sspgwirrvmhiqhnDVS--TVYLVCHVINH-TFTWSVIGVPkSPEDLIAFMGEVETCytetegEGGKPIILHCSAGVGRTGTFCVIFSAIREFtahnGI
               ..     ..  ..|..  . ..  ..| ..||. .|.  .|..      . |.|.. ||.||.||||||.|.   .. .    |.
...............eelydpelferlgikylripvpDgsap.lledfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkll....gv

iNIPRMVRTLRQQRK-----YMV
 ..   .. .|..|       ..
.sleealedvrlkRpinpnpgfi
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1201-1377 1.5e-19 64.8 In-house 82-246 (281) alignment 
Range on Protein: 1201-1377
Range on HMM: 82-246/281.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDvsTVYLVCHVINHtfTW
 .| ||||   | |||| |.|....  |||| . .| |. || .|.| .      |  . || .  |     .   . . ..      |. | . .   |
gyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyeg..etrlithwlwk..ew

SVIGVPKSPEDLIAFMGEVETCYTetegeggkPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQ
    ||.| | ..  . .. .  |        | ..||||||||.||.  .  |..   .|  . .| ..|  ||  
pdwqvpessevmlkilrkirarst........ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1201-1384 2e-18 61.4 In-house 83-256 (288) alignment 
Range on Protein: 1201-1384
Range on HMM: 83-256/288.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTsspGWIRRVMHIQ----HNDVSTVYLVCHVinH
 .| .| |. .|.  .| |. |..   ||||.. .|  | |  .|.|   |..  .| .    |        | .....     .. . .  .| ..  |
rlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr...adidklvkvsllriskegeekvivkil..h

TFTWSVIGVPKSpedliaFMGEVETCYTEteGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAhNGIINIPRMVRTLRQQRKYMVQK
   |   |||..      ..  .  .      .  |||..|.|||||||||. .|. |..     .  . |....  ||..|.  .| 
lleWdddgvPen......ylsplrllevl..kslqkPivvhssaGvGrtgtlililialeslrl.ddflgirsllaklreerfkaiqt
subfamily_ptpA1_pd Subfamily ptpA1 1201-1251 4.8e-15 50.2 In-house 90-140 (418) alignment 
Range on Protein: 1201-1251
Range on HMM: 90-140/418.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEG
 ||.||||.  |.|||| ||||..  .||||..| |  ..|| .||| . |
qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1201-1383 2e-11 38.2 In-house 83-260 (312) alignment 
Range on Protein: 1201-1383
Range on HMM: 83-260/312.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFgPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVC---HVINHT
 |..||||. .| . || ..    |  |..|.  ||    || .|     |  .|    ||  .. |      .   .| |  .  |         .|| 
rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle.dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhy

--FTWSVIGVPKSPEDLIAFMGEVEtcytetegEGGKPIILHCSAGVGRTGTFCVIFSAIREFtAHNGIINIPRMVRTLRQQRKYMVQ
   .|   |.| | .    ..  |            ||.| |||||||||||...| | |  .  |    |.  .   ||..|   |.
qwaswpdhgmpdscdtalrllsavk........kdkkpviahcsagvgrtgtlaliesmiaal.rhprkqnvkdsfvllrkdrarsvr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1201-1264 3.3e-08 27.3 In-house 237-296 (440) alignment 
Range on Protein: 1201-1264
Range on HMM: 237-296/440.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEvegNKLKCHQYWPIDEgHTNLFGPMRVSLK
 ||||| |. ||. ||| .| . .   |.|| .    |   |  |||..   .  |||. |  |
afiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvnt.rsvtfgpftvghk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1201-1247 8.2e-08 25.9 In-house 108-154 (349) alignment 
Range on Protein: 1201-1247
Range on HMM: 108-154/349.0
PFIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWP
 .|||| |. ||. ||. ..  .. .... |... | .  ||..|| 
kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
subfamily_PTPRD_pd Subfamily PTPRD 1202-1385 5.9e-56 185.2 In-house 93-267 (564) alignment 
Range on Protein: 1202-1385
Range on HMM: 93-267/564.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDeGhTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinHTFTWS
.||||||.|.|..||| |||||.| .|||||| .| .| |||.||| . | |  .| . |.|.. .     . | . ..... | .  | .   |   | 
yIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqF..hFtsWP

VIGVPKSPEDLIAFMGEVETCYtEtegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAhNGIINIPRMVRTLRQQRKYMVQKK
  |||.|...|.... .|...  |   .. .||. ||||||||||||.|| . ..  .. .. ..|  .|..||.||..|||..
dhgvpesatslLdlirkvraln.e...pdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqte
subfamily_PTPN13_pd Subfamily PTPN13 1202-1385 5.1e-44 145.6 In-house 79-255 (273) alignment 
Range on Protein: 1202-1385
Range on HMM: 79-255/273.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNL-FGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHViNhTFTW
.||.|||.  | .|||.|||||.. ||.|.|.|.|..|.|||.|||  ....    . ..|.|  ..   |.  | ....... . .  | |. |   .|
yiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahl.n.fvkw

SVIGVPKSPEDLIAFMGEVETCYTETegeggKPIILHCSAGVGRTGTFCVIFsAIREFTAHNGIINIPRMVRTLRQQRKYMVQKK
   |||.|...|. |. || .  |..      ||. |||||.||.||. .|  .. .  ...  ...  .||.||.||. .|| |
PdhgvPssaaellqfvaevrrlqtda.....gPivvhcsaGiGrsGtlitid.vvlglierdkefdvkeivrklreqrqgvvqtk
subfamily_PTPN9_pd Subfamily PTPN9 1202-1384 1e-43 144.5 In-house 87-275 (297) alignment 
Range on Protein: 1202-1384
Range on HMM: 87-275/297.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinHTFTWS
|||||||.  |  |||.|||||.  |||| |. ||  .||| |||| .|.... || ..||  .  ..  .  ||..|.. . .    | |      .| 
fiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthf..qflsWP

VIGVPKSPEDLIAFMGEVETC---YTET------EGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTaHNGIINIPRMVRTLRQQRKYMVQK
  |||.| ..|. .. .|       ...          | ||..|||||.||||||. .  .. ..  . | ...   |..||.|| ...| 
dyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle.evgtvdvvetvkllrtqrafsiqt
subfamily_PTPRA_pd Subfamily PTPRA 1202-1385 7.5e-43 141.6 In-house 103-281 (330) alignment 
Range on Protein: 1202-1385
Range on HMM: 103-281/330.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPiDEGHTNlFGPMRVSLKSLTSSPGWIRRVMHIQ-HNDVSTVYLVCHVIN-HTFT
|||.||| . |. ||| |.|||.|  |||||.  | .. ||.|||| |||    .| .||...  | .  .  | . .|  .| .    .  | . |  .
fiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP.deGlvt.yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhfts

WSVIGVPKSPEDLIAFMGEVETCYTETegeGGkPIILHCSAGVGRTGTFCVIfSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKK
|  .|||  |  .. .. .|...   .   .| ||..||||||||||||.|. .|. |    ...... ..|. ||.||  ||| .
wPdvGvPfepiGmlkllkkvkklnqqs...ag.pivvhcsaGvGrtGtfivl.davlervkaerkvdvfefvkrlrlqrpqmvqtd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1202-1385 4.4e-41 135.9 In-house 94-270 (297) alignment 
Range on Protein: 1202-1385
Range on HMM: 94-270/297.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKlKCHQYWPiDEGHTNlFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinHTFTWS
.|.|| |  .|.|||| ||...|  .||||... |..| || .||. |.| |. || . | |.|...  | |.| .......  .  .|     .   | 
littqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs.dkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqy..qfveWP

VIGVPK--SPEDLIAFMGEVETCYTETeGEGgkPIILHCSAGVGRTGTFCVIFSAIREFTAhNGIINIPRMVRTLRQQRKYMVQKK
.  |..  | . |. .. ||.  . ..  ||  |...||.||||||| .. | | . |    .  ..|  .|. |||.| |.|| |
dkaverkdsassllklisevrkdfsqn.aeg..PllvhclaGvGrtgvlltidsvvaeakr.ekevdifglvkklrqerpylvqtk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1202-1389 1.1e-38 127.8 In-house 93-273 (290) alignment 
Range on Protein: 1202-1389
Range on HMM: 93-273/290.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDeGHTNlFGPMRVSLKSLTSSPGWIRRVMHIQHNDVStvYLVCHVINHTF-TW
.||||||. .||.||| ..|......|||||...| .| ||.||||   . .. .|.... | . ..  . |.| ....... .      .|... . .|
yiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsa..gakqsvtqyqitnw

SVIGVPKSPEDLIAFMgevETCYTETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTaHNGIINIPRMVRTLRQQRKYMVQKKVILQ
   |  . |.  .  .   |  |     .| ..|..|||..|||...||..  .|      .| |..  .....|.|.  .|| .. .|
dstgkvtnpqtillvi...eemyktqrkrgntsivvHCSdtvgrsavfcaaattinkck.tegvidvfqvlksqRiqkpgsvqtvqqyq
subfamily_PTPN14_pd Subfamily PTPN14 1202-1384 1.5e-38 127.5 In-house 95-281 (300) alignment 
Range on Protein: 1202-1384
Range on HMM: 95-281/300.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDE--GHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVinHTFT
.|..|||.  |. ||| |||||.  .|||||.| |. | |...|.| .|   .|  ||  .|. |  ..|.  | . ....|   .    | |.      
yivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhl..qytD

WSVIGVPKSPEDLIAFMGEVETCYTETEGEG-----GKPIILHCSAGVGRTGTFcVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQK
|.  |||. ... . .. ||.    .|. |        |...||||||||||   ..   . .   ||  |.|......||.|| ..|| 
WpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvl.ilsdlliatlehneeidikkvlarLreqrmllvqt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1202-1384 5.8e-37 122.5 In-house 93-273 (325) alignment 
Range on Protein: 1202-1384
Range on HMM: 93-273/325.0
FIATQGPIASTLADFWLMVWEQQSPVIVMlTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVcHVInHTFTWS
|.|.| | ..|. |.| .| . ...|.|. . |....| .| .||| . |..  ||...|.|...     .. ||....  .      | .   .  .| 
flaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsv.kqf.qlqswd

VIGVPKSPEDLIAFMGEVETCYTE--TEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTaHNGIINIPRMVRTLRQQRKYMVQK
 .||.| |  ||...  |..      .. ..  ||..||||||||||.|  ..||. .   ..  ..|  .|. ||..|  ||. 
dmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvi.eesrvdifgfvkklrkdrpsmvet
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1202-1386 7.7e-37 122.3 In-house 106-278 (319) alignment 
Range on Protein: 1202-1386
Range on HMM: 106-278/319.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTkevegnKLKCHQYWPIDEGHTnlFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVChVINHTFTWS
.||.|||   |||||| |.||...  ||.||      | || |||| .   .   . . |...|.. .  .. | ... ..   .         |   | 
yiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik..eerfkvkvdsveetaeyvvrdielsedgkekdirki.tqfhflGwp

VIGVPKSPEDLIAFMGEVETCYTETegEGGKPIILHCSAGVGRTGTFCVIfSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKKV
  |||..| ||. ..  |.   .    .. ..|..||||||||||.. |.  .. .   ..  ... ..|| |||||. .||. |
dvGvpdypsdlmrlvkkvrhltske..nhranivvhcsaGvGrtGvyivl.dvlldrmkeekqvdvynfvrdlrqqrntlvqdlv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1202-1386 1.4e-36 121.5 In-house 70-242 (284) alignment 
Range on Protein: 1202-1386
Range on HMM: 70-242/284.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTkevegnKLKCHQYWPIDEGHTnlFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVChVINHTFTWS
.||||||   |||||| |.||...  ||.||      | || |||| .   .   . ..|...|.. |  .. | ... ..   .         |   | 
yiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik..eerfkvkvdsveeseeyvvrdielsedgkekdirki.rqfhflgwp

VIGVPKSPEDLIAFMGEVETCYTETegEGGKPIILHCSAGVGRTGTFCVIfSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKKV
  |||..| ||....  |.   .    .. ..|..||||||||||.. |.  .. .   ..  ... ..|| |||||. .||. |
dvgvpdypsdlmrlvkkvrhltske..nhranivvhcsagvgrtgvyivl.dvlldrmkeekqvdvynfvrdlrqqrntlvqdlv
subfamily_PTPRG_pd Subfamily PTPRG 1202-1385 3.6e-36 119.5 In-house 93-273 (563) alignment 
Range on Protein: 1202-1385
Range on HMM: 93-273/563.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTnlFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVY---LVCHVIN-HT
|||||||...|. ||| |.|||.. .|||.|. || .. ||..||| ||  |  .| ..| |..         | . |..  .        . .|.. | 
fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdeset..ygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhy

FTWSVIGVPKSPEDLIAFMGEVETCYTETEGeggkPIILHCSAGVGRTGTFCVIFSAIREFTaHNGIINIPRMVRTLRQQRKYMVQKK
 .|   |||...   . |.   ..   .. |    ||. |||||||||||..|. . ...   .. ..|. ......| || ..||..
tkWPdhgvPehslpvLifvkkssaankaeaG....PivvHcsaGvgrtGtyivldtllkqiq.qenavnvfgflkhiraqRnflvqte
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1202-1387 7.6e-36 118.5 In-house 66-252 (270) alignment 
Range on Protein: 1202-1387
Range on HMM: 66-252/270.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGH--TNLFGPMRVSLKSLTSSPGWIRRVMHIQhNDVSTVYLVcHVINHtfT
.||..|| ..|| .|| |.||.... |||.|. .| .. || .||| . ..  .  .| ..|   | . . |.|.. .... .. ..  || |   .  |
YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.Hfwyn..t

WSVIGVPKSPE------DLIAFMGEVETCYTETEGEGgkPIILHCSAGVGRTGTFCVIFSAIREFtAHNGIINIPRMVRTLRQQRKYMVQKKVI
|   |||....      .|.. . .|    .|.. ..  |.. |||||||||||. ..  |.|    ... ... .... ||..|  .||. . 
Wpdhgvpreedsslstdqllkmlravrrsekeldkae..PllvHcsaGvgRtGtlialDiavrlL.eetkkvdvlaiieelRkdRmalvqhpeq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1202-1384 2.6e-35 116.8 In-house 88-263 (287) alignment 
Range on Protein: 1202-1384
Range on HMM: 88-263/287.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGhtNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVchVINHTF-TW
||....|...|. .|| ...... ..||||..| | .. .|.|||| ..    ..|. ...| . . . |.| | ....... ..  .   |  . . .|
fiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqq..vkqyqitnW

SVIG-VPKSPEDLIAFmgevETCYTETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREfTAHNGIINIPRMVRTLRQQRKYMVQK
   | |..    |. .    |  | .   .|  .|. |||..|||...|| .  .|.. .  .|.|.. ....  |.|.  .|| 
dstgkvtepqtillvi....eemyktqrkrgntsivvhCsdtvGrsamfcaaattink.ckteGviDvfqvlksqriqkpgsvqt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1202-1389 4.8e-33 109.2 In-house 82-267 (287) alignment 
Range on Protein: 1202-1389
Range on HMM: 82-267/287.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVcHVInHTFTWS
|||.|||||.|. ||| .|.|..| .....|.|||  .|||..|||  |    . |   | |.    .| .  | . . . .     .| . . . ..| 
fiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvv.kql.dllswP

VIGVPKSPEDLIAFMGEV-ETCYTETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREfTAHNGIINIPRMVRTLRQQRKYMVQKKVILQ
  ... .   || |. .| .    . ....  |...|...|.||.|..  ..  ..      | ... ..|  ||..|. .||  | |.
dkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr.ledlGrvdvaavvirlreyraalvqavvqlr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1202-1385 8.9e-33 108.5 In-house 94-265 (315) alignment 
Range on Protein: 1202-1385
Range on HMM: 94-265/315.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPiDEghTNLFGPMRVSLKSLTSSPGWIRRVMHIQH-NDVSTVYLVchvinHTFTW
.||.||| .... ||| .|.|..   |||||. |||.| |. .||| |.    ..|.. |..||      .  | . .   ... .|. .     |  .|
yiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp.dk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvql.....hytsw

SVIGVPKSPEDLIAFMGEVETCYTETEgeggKPIILHCSAGVGRTGTFCVIFSAIREFTAHNgIINIPRMVRTLRQQRKYMVQKK
  .||||.   |. ..  |    |..      .|..||||||||||||. . . . .  | | .|.. .... .||.|. |||  
pdmgvpkytiplmnlirtvkqhhtnsv....gaivvhcsaGvGrtGtfitldavldqaeaen.aidvynfitgvrqnrikmvqva
0051429 (Phosphotyrosine protein) phosphatases II 1202-1386 7.8e-31 103.1 In-house 24-212 (272) alignment 
Range on Protein: 1202-1386
Range on HMM: 24-212/272.0
FIATQGPIASTLADFWLMvWEQQSPVIVMLTKEVEGNKLKCHQYWP----------IDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYlVC
.....||   | |||| . .|..  .||.|..|.| ..|||..|||           |.  | |.| .|| | | .  . .| |.. . .    . .   
lyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea.re

HVINHTFTWSVIGVPKSPedLIAFMGEVETcytetegegGKPIILHCSAGVGRTGTFCVIFSAIrEFTAHNGIIN--------IPRMVRTLRQQRKYMVQ
. . |   |   |||...  |.... .. .         |.|.. |||||..||||.....  . .   .. |..        . . |. ||.|| ..||
vmhlhytdwpdhgvpqea..llellellld.........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavq

KKV
   
tee
subfamily_CG7180_pd Subfamily CG7180 1202-1385 1.9e-27 90.7 In-house 87-276 (296) alignment 
Range on Protein: 1202-1385
Range on HMM: 87-276/296.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKlKCHQYWPIDEghTNLFGPMRVSL---KSLTSSPGWIRRVMHI------QHNDVSTVYLVCH
.| |..|  .|. .|| .|.....  .|.|||. . .| ....||| .    . .|.. | .   |...    .  ....       |...|..   ...
yivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivk

VINHTfTWSV-IGVPKSPEDLIAFMGEVETCYTET-EGEGGKPIILHCSAGVGRTGTFCVIFSAIrEFTAHNGIINIPRMVRTLRQQRKYMVQKK
... | .| .   || | . || ..  |..   .. | .  .|.. ..| |..|.| .. |  .. |   ... ... ..|.|||..|. .|...
lfqlt.eWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanl.elvekeeevdvFeavktlrrsRpqLvenv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1202-1384 3.9e-24 79.9 In-house 93-264 (439) alignment 
Range on Protein: 1202-1384
Range on HMM: 93-264/439.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKlkchqYWPIDEghTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVINHTFTWS
.||||||   |  ||| .|.|...  |||||. ||  |     ||| |.     .| . |        | .. | ...  .  .|      .  |  .| 
yiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda..evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawp

VIGVPKSPEDLIAFMGEVETCYTETEGeGgkPIILHCSAGVGRTGTFCVIFSAIREFTAHNGiINIPRMVRTLRQQRKYMVQK
   ||     .. |.  ....  . |  |  |...|||||||||||   .  |. .. . |  ..|  .|. ||.||| |||.
dknvpaqashvldflrainsandkeey.g..pvvvhcsagvGrtGtiialdialeqlklenk.vdikgivkvlrkqrkqmvqa
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1202-1380 9.3e-20 65.6 In-house 6-184 (198) alignment 
Range on Protein: 1202-1380
Range on HMM: 6-184/198.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNdVSTVYLVCHVINHTFT-W
.|||| |.  |||||| ||||  |  |||.  .   ..     |||  |  |  .| . |. |..|. | .   .. .  | ...      .  . || |
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnn.ttappstreishyqftsw

SVIGVPKSpEDLIAFMGEVETCYTETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFT-AHNGIINIPRMVRTLRQQRKY
     |.    .. |.          | |   |.|.||| | | || |  .   .|    ..  ....  . . ||| |  
kekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcg
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1202-1380 9.4e-20 65.6 In-house 7-185 (199) alignment 
Range on Protein: 1202-1380
Range on HMM: 7-185/199.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNdVSTVYLVCHVINHTFT-W
.|||| |.  |.|||| ||||  |  |||.  .   ..     |||  |  |  .| . |. |..|. | .   .. .  | ...      .  . || |
yiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnn.ttappstreishyqftsw

SVIGVPKSpEDLIAFMGEVETCYTETEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFT-AHNGIINIPRMVRTLRQQRKY
     |.    .. |.          | |   |.|.||| | | || |  .   .|    ..  ....  . . ||| |  
kekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcg
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1202-1385 3.4e-19 63.9 In-house 74-245 (267) alignment 
Range on Protein: 1202-1385
Range on HMM: 74-245/267.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNklkCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVchvINHTFTWS
||.||.|.  | .||. .. .|. ||||.|||  ..|    ...||   |... .  . |          .   .. .. .. |.  ..   . .   | 
fivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvt...lyyykkwn

VIGVPKsPeDLIAFMGEVETCYTEtegEGGKPIILHCSAGVGRTGTFCVIFSAIREFtAHNGIINIPRMVRTLRQQRKYMVQKK
.    | |  |  ..| .     |   .|..|....||.||||.||| || | ..    ..|. .|  ..| .|.||  .|. |
intnnk.p.ylkplfgilaknqle...ngnrPlvvacsdGvGrsGtflvidsqlera.ktegvsdifdflrkirsqriglvdtk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1202-1388 3.5e-18 60.6 In-house 77-259 (285) alignment 
Range on Protein: 1202-1388
Range on HMM: 77-259/285.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTS--SPGWIRRVM-HIQHNDVSTVYLVCHVINHTf
.|.||||.  ||.||| |.....   ..||   .||   ||  |.|   |    ||   ..|         | |   .  |. .| |.  |    ..   
yittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvp.

TWSVIGvpkSPEDLIAfMGEVETCYTETeGEGGKPIILHCSAGVGRTGTFCVI-FSAIREFtaHNGIINIPRMVRTLRQQRKYMVQKKVIL
 |       .|||    | |.     .      ||| .||||||||| ||  | ...|| .   |  |..  .|| .|  |   || .. .
wwpdql...apedarp.mielykwvkkv.npkekpicvhcsagvgrtatfvgidyatirim..enpniemldivremramrfqavqshmqf
subfamily_CG42327_pd Subfamily CG42327 1202-1322 8.7e-18 59.0 In-house 74-193 (319) alignment 
Range on Protein: 1202-1322
Range on HMM: 74-193/319.0
FIATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGH--TNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHvinHTFT
.||.| .  .. .||| .|||||| ||| ||.  |    .| .|.|  |.   |.|.| ..|.||   .   ..   . ... | .    . |   . . 
yiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelth...ywyk

WSVIGVPKSPEDLIAFMGEVETC
|   .|| ... ||| . ||.. 
wleaevPaeeaaliamllevrss
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1203-1384 3e-09 30.9 In-house 86-264 (303) alignment 
Range on Protein: 1203-1384
Range on HMM: 86-264/303.0
IATQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFG-PMRVS-LKSLTSSPGWIRRVMHIQHNDVSTVYlvcHvINHTFTW
| || |.. | |||| |. ||.  ....|  . | .||  .  .| ..   ..    .||  .| .  . ||  .|. .   |  .     | . |  .|
iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksfl...h.vhhykaw

SVIGVPKS-PEDLIAFMGEVETCYTETegEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQK
    .|      ..  . ....         ..| .    .|.||.|||... .|   . . .  ... . . ..|. | . ||.
phnsipsdgspkfvkqiwqlqsvlrky..sdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqn
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1205-1385 3e-15 51.1 In-house 72-245 (290) alignment 
Range on Protein: 1205-1385
Range on HMM: 72-245/290.0
TQGPIASTLADFWLMVWEQQSPVIVMLTKEVEGNKL----KCHQYWPIDEGHTNLFGPMRVSLKSLTSSPGWIRRVMHIQHNDVSTvYLVCHviNHTFTW
.    .||. .|| |. . ..  .||| .  | ..      | .| |  .|    |. . |. ||     . ..| . ....|    . | |  .    |
itekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeee.ftvtH..sllkgW

SVIGVPKSPEDLIAFMGEVEtCYTEtegeggkPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKK
. . |....  |.. .  |. ...        |.|.||  |. |  ..  |  .   .   .| ...  .. .||.||  .....
nklnvqedtktllsliqkvk.askt.......pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsa
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1208-1386 3.7e-09 30.5 In-house 99-275 (302) alignment 
Range on Protein: 1208-1386
Range on HMM: 99-275/302.0
PIASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRV-------SLKSLTSSPGWIRRVMHIQHNDVSTVYLVCHVINHTFTW
|  |||  .| .. . .  ..| |.. ||... || .|.  . | .  ||   |        |. .|   .     . |. . . .       | .  .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

SVIGVPKSPEDLIAFMGEVETCYtetegeggKPIILHCSAGVGRTGTFCVIFSAIrEFTAHNGIINIPRMVRTLRQQRKYMVQKKV
   | || ..  .  .   |.          | ...|||||||||||.  |   | .. ... . ..  .|  .|| |   ||.. 
pdhGapkeaytaldilkfcesyk........knvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1209-1384 4.4e-10 34.1 In-house 39-206 (255) alignment 
Range on Protein: 1209-1384
Range on HMM: 39-206/255.0
IasTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSltSSPGWIRRVMHIQHNdVSTvYLVCHVINHTF--TWSVIGVP
.  |.. |. ..  ... |.|||.   | .. ||..|.|..      .  . |.     ||   . | ..|  . ..      | ..| .   |     |
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitst.lge.kkkthtvkhysykGWieknaP

KSPEDLIAFMGEVEtcytetEGeggKPIILHCSAGVGRTGTFCVIFSAIR----EF-TAHNGIINIPRMVRTLRQQRKYMVQK
. ....   .  |       .    |....|||.|.||. .| .. .. .     . |.. . ..  .... ||..||  ...
elareilnilkvvr......ds...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht
subfamily_hpo-7_pd Subfamily hpo-7 1210-1383 8e-07 23.2 In-house 44-211 (263) alignment 
Range on Protein: 1210-1383
Range on HMM: 44-211/263.0
ASTLADFWLMVWEQQSPVIVMLTKEVEGNKLKCHQYWPIDEGHTNLFGPMRVSLKSLTSspGWIRRVMHIQHNdVSTvYLVCHVINHTF--TWSVIGVPK
  |.. |. ..  ... |.|||.   | .. || .|.|..      .  . |.     |    . .  ..  . ..      | ..| .   |     |.
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellst.lge.KkkthtvkhysykgWiekndpe

SPEDLIAFMGEVeTcytetegeGGKPIILHCSAGVGRTGTFCVIFSAI----REF-TAHNGIINIPRMVRTLRQQRKYMVQ
 ... .  .  . .        . |... |||.|.||.  | |. ..     | . |.. . ..  .... ||..||  ..
lareilnilkva.r........nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraih
0048076 (Phosphotyrosine protein) phosphatases II 1275-1389 5.6e-15 50.8 In-house 21-133 (145) alignment 
Range on Protein: 1275-1389
Range on HMM: 21-133/145.0
RVMHIQHNDVSTVYLVCHVIN---------HTFTWSVIGVPKSPEDLIAFMGEVETCYTEtegegGKPIILHCSAGVGRTGTFCVIFSAIReftahNGiI
.. ....... ||. ... ..         . . |   ||| ..|.|..|.  .|... |     |.|.. |||||||||||.....  ..     .| .
dlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsaGvgRtgtlvaaylmll.....lg.v

NIPRMVRTLRQQRKYMVQKKVILQ
...  .. .|.|| ..|.    |.
sleealelvrsqrpgavpnpgqlr
0038934 (Phosphotyrosine protein) phosphatases II 1275-1373 3.7e-07 25.5 In-house 48-157 (194) alignment 
Range on Protein: 1275-1373
Range on HMM: 48-157/194.0
RVMHIQHNDVSTVYLV---------CHVINHTFTWSVI-----GVPKSPEDLIAFMGEVETCYTETEgegGKPIILHCSAGVGRTGTFCVIFSAIREFTA
|... .. .. .|. .         ... .. ...  .     |.. | | |  |.  |.. . | .   |. .  || ||.|||||... .   |    
rylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp...ggvvaVHCkaGlgRtGtlvaaYLiyrlgms

HNGIINIPRMVRT
 .  |.. |..| 
aeeAialfrekRp
0048179 (Phosphotyrosine protein) phosphatases II 1277-1391 7.1e-15 50.5 In-house 23-137 (144) alignment 
Range on Protein: 1277-1391
Range on HMM: 23-137/144.0
MHIQHNDVSTVY-----------LVCHVINHTFTWSVIGVPKSPEDLIAFMGEVETCYTetegeGGKPIILHCSAGVGRTGTFCVIFSAIreftaHNGiI
 ........||.            . ..  . . |   ||| ..|.|..|.  .|...       |.|.. |||||||||||.....  .     ..| .
ellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgtlvaaylmk.....klg.l

NIPRMVRTLRQQRKYMVQKKVILQKL
..   .. .|..| ..|.    |. |
sleealalvrsrrpgavpnpgqlrfL
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1295-1384 4.2e-08 26.9 In-house 94-179 (440) alignment 
Range on Protein: 1295-1384
Range on HMM: 94-179/440.0
NHTFTWSVIGVPKSPEDLIAFMGEVETCyteTEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAhNGIINIPRMVRTLRQQRKYMVQK
 |   |   ||||    .. .. .|. .    |  |  |...|||||.||||   .. | .||    .  |.|  .. ..|..|  ||| 
yhyqgwpdkgvpkfagpvlkmiqdvnes...qekagngpllvhcsagagrtgviiavdsilreakr.sdqidifsfinsmrnnrpqmvqt
PTPc_DSPc_SM00012 1296-1385 5.7e-21 70.1 In-house 6-93 (105) alignment 
Range on Protein: 1296-1385
Range on HMM: 6-93/105.0
HTFTWSVIGVPKSPEDLIAFMGEVETCYTETEGegGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKK
|  .|.  |||....... .. .|...... |   .||...||||||||||||...  ... ...... ..| ..|. ||.||  ||| .
hytgwpdhgvPeesdsilellravkknknkses..skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1326-1381 3.8e-08 27.4 In-house 257-326 (350) alignment 
Range on Protein: 1326-1381
Range on HMM: 257-326/350.0
TEGEGGKPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIIN--------------IPRMVRTLRQQRKYM
 . . ..||. |||||||||||.. . | . .|   . . .              |  .|  ||.||  |
ldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrism
subfamily_CG42327_pd Subfamily CG42327 1332-1385 3.4e-08 27.5 In-house 248-301 (319) alignment 
Range on Protein: 1332-1385
Range on HMM: 248-301/319.0
KPIILHCSAGVGRTGTFCVIFSAIREFTAHNGIINIPRMVRTLRQQRKYMVQKK
 |...||| ||||||.      |||..   .  ..||..|  .|..|   |..|
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltk
subfamily_ptpA1_pd Subfamily ptpA1 1332-1352 7.6e-06 19.9 In-house 230-250 (418) alignment 
Range on Protein: 1332-1352
Range on HMM: 230-250/418.0
KPIILHCSAGVGRTGTFCVIF
 |||.|||||||||||||   
vpiivhcsagvgrtgtfctav