Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
0039614 | (Phosphotyrosine protein) phosphatases II | 40-319 | 7.5e-85 | 280.2 | In-house | 15-290 (297) | alignment | ||
Range on Protein: 40-319
Range on HMM: 15-290/297.0
KSKLITFEELGECVDNTKQLYAEFWEIPMNH-PPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPD-DPLSSYINANVLKGYGEEINAFIATQGPLSCTV
. . ... | | ... .|..||.|.. . . . .|| . .|||..|||. ..|| | ... |. |.||||. ..|| ..||||||||. ||
plsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv
NDFWRMIWYHHCPIIVMITKLKERNEtKCERYWPDPTFrmqeKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLV
.|||||.| .....|||.|||.|.. ||..|||. . .|||..||. . .||| .. | ..... .| ..|..|| |||||||.|...||...
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefl
DEVHLAQDRDdGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHWR
..|. |. .. .| |||.||||||.||||.|.| . . |..|| .||.|..|. .|. |.|.|.|.|||.|.|.||.....
elvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 47-318 | 1.1e-86 | 286.2 | In-house | 32-299 (308) | alignment | ||
Range on Protein: 47-318
Range on HMM: 32-299/308.0
EELGECVDNTKQLYAEFWEIPMNHPPAE---ERLPGSSYRNRYPSILPNSRTRVSLpqipdDPLSSYINANVLKGYG-EEINAFIATQGPLSCTVNDFWR
.| | .....|..||.|.... |. | .|| .|||..|||. ..|| | |. |.||||. .|| ..||||||||. ||.||||
lkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr
MIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEV
|.| .....|||.||| |.. ||..|||. . . ..||...||. | .|.| .. |.... .. |...|..||.|||||||.||..||.....|
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv
HLAQdrddgKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
. . . ||.|||||||.||||.|.| . . |..||..||....|. .|. | |||.| .||.|.||||....
rksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 53-318 | 5.6e-87 | 287.1 | In-house | 19-286 (288) | alignment | ||
Range on Protein: 53-318
Range on HMM: 19-286/288.0
VDNTKQLYAEFWEIPMNHPPA---EERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHC
.....|..|| |.. . |. .|| .|||..|||. ..|| | ..... |.||||. ..|| . ||||||||. ||.|||||.| ...
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnv
PIIVMITKLKERNETKCERYWPDptfRMQEKYGDIVVTFDSALGRDGYQITSLYIS------HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLA
..|||.||| |.. .||..|||. . ..||||.||. | |.| .. |... .. .|. .|..||.||||||||||..||... .|. |
rvIvmltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka
QDrddGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
. . ||||||||||.||||.|.| . . |..||..||.|..|. .|. | |||.| .||.|||.||....
la...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 53-318 | 5.5e-70 | 230.8 | In-house | 28-295 (330) | alignment | ||
Range on Protein: 53-318
Range on HMM: 28-295/330.0
VDNTKQLYAEFWEIPMNHPPAEERLP---GSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEeINAFIATQGPLSCTVNDFWRMIWYHHC
|..|.. || .| . | | .||.. |||. .|| |... . | |||| ..|| | . |||.|||.. ||.||||||| ..
addnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyke.kdkfiaaqGPkeetvedfwrmiweqks
PIIVMITKLKERNETKCERYWPDPTFrmqEKYGDIVVTFDSALGRDGYQITSLYIS------HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLA
|||.|.||||.|.||..|||| ||.| |. . | . . . . ...| . . .|.||| ||| |. .|.|. .|.
ativmltelkerkeekcaqywPdeGl...vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl
QDRddgKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
... ..||.|||||||.|||| |.. . ..... |.|||. ..| .|. | || || ||||.|..| ...
nqq...sagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 54-320 | 5.6e-126 | 414.2 | In-house | 2-270 (274) | alignment | ||
Range on Protein: 54-320
Range on HMM: 2-270/274.0
DNTKQLYAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSL-PQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPII
...|.|..||.|.|.|....|....||...||| .||||...||.| .. ..|..|||||||..|||.|| .|..||||||..||.||||||.......|
rsfkdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi
VMITKLKERNETKCERYWPDPT-FRMQEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDGKT
||.|||||.||.||..|.|| . ....|.|||. ....... |..|....|........|...|||||.|||| .||....||.||.||. ...... |.
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakl
GPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHWRQ
.||||||||||||||||.|.||...|...|..||.||||| .|..|||||.|..|||...|||......
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 54-316 | 6.5e-82 | 270.3 | In-house | 9-270 (273) | alignment | ||
Range on Protein: 54-316
Range on HMM: 9-270/273.0
DNTKQLYAEFWEIPMNHPPA---EERLPGSSYRNRYPSILPNSRTRVSLpqipDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCP
.....|..|| ... . |. .|| .|||..|||. ..|| | .|. |.||||. ..|| . . ||||||||. ||.|||||.| ....
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvr
IIVMITKLKERNETKCERYWPDPTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDD
.|||.|.| |.. ||..|||. . ..||.. ||. | .|.| .. |.... .. .| .|..|| |||||||.|. .||.....|. |. .
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp
GKtGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
.. ||||||||||.||||.|.| . . |..||..||.|..|. .|. | |||.| .||.|.|.||..
sn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 54-316 | 4.9e-60 | 198.5 | In-house | 31-289 (319) | alignment | ||
Range on Protein: 54-316
Range on HMM: 31-289/319.0
DNTKQLYAEFWEIPMNHPPAEE----RLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHC
|. ..| .|| .. .. . |. .||. ||. ...| | .. | |||| ..|| . . .||.|||| |..||||||| ..|
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrk.dkyiaaqGPldntladfWrmiweync
PIIVMITklkernETKCERYWPDptfRMQEKYGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDE-VHLAQD
||..| . || .||| ....|.. | || . | . .. .|. . |.. . . |||.||||.| .|..||. || .
stivllt......kdkcsqywpl...kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk
RDDGKtgPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
.. . ..|||||||.|||| ... . ......|..||. ..| ..| .| .|. || |.| ||
enhra..nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 55-318 | 1.5e-79 | 263.3 | In-house | 25-304 (307) | alignment | ||
Range on Protein: 55-318
Range on HMM: 25-304/307.0
NTKQLYAEFWEIPM-----NHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDD-PLSSYINANVL--------KGYGEeINAFIATQGPLSCTVNDF
. |..|| ... ... . .|| . .|||..|||. .||| | .... . |.||||. .|| ..||||||||. ||.||
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedF
WRMIWYHHCPIIVMITKLKERNETKCERYWPDPtfRMQEKYGDIVVTFDSALGRDGYQITSLYIS---HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLV
|||.| ... .|||.|.|.|.. || .|||| . . ||...||. | |||... | .. .. .|...|..||.|||||||.|. .||...
wrmlweqgvtvivmltelvelgrekcaqywPde..geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfi
DEVHLAQDRDdGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENK---VDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
.||. |.... .| |||.||||||.||||.|.| . ..|..||.. ||.|..|. .|. |.|.|.. .||.|.|.||....
eevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 56-315 | 4.3e-68 | 224.7 | In-house | 21-280 (305) | alignment | ||
Range on Protein: 56-315
Range on HMM: 21-280/305.0
TKQLYAEFWEIPMNHPPAE-ERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVM
.|.| |.. ...... . . .. . .||. .| . |. | . .... | ||||. ..|| .. ...|..|||| ||.||||.|. . |||
dkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrk.kkyivaqgPlkntvadfWrliveekvstivm
ITKLKERNETKCERYWPDPTfRMQEKYGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgKT
.|||.| .. ||..|||. . . ....|...|. | .| . | || .. | . .| | |||||||... ||.|...|. .| .| |
ltklveggkdkCrqYWpesk.tekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd..kg
GPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|..||||||.|||| |.| .| . ...||. ||. ... .| .| .||.| || |.. ||
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdald
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 57-318 | 6.1e-82 | 270.7 | In-house | 18-276 (317) | alignment | ||
Range on Protein: 57-318
Range on HMM: 18-276/317.0
KQLYAEFWEIPMNHPP--AEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCPIIVM
..|. ||.... .... . .|| . .||||.|||. ..|| | .. |. |.||||. .|. . . ||||||||. ||.|||||.| ... .|||
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgvtvivm
ITKLKERNETKCERYWPDptfRMQEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddGKTG
.|.|.|.. ||..|||. . .|||..||. | .|.... | ... .. .|...|..||.|||||||.||..||.....|. |.. .. |
LteleelgrekcaqYwpl...getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dpgg
PVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
||.||||||.||||.|.| . . |..||..||. ..|. .|. |.|.|.| .||.|.|.||....
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 57-318 | 6.2e-81 | 267.3 | In-house | 16-277 (297) | alignment | ||
Range on Protein: 57-318
Range on HMM: 16-277/297.0
KQLYAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLpqipDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCPIIVMIT
.. . |.... . . .||. .|||..|||. .||| | ||. |.||||. ..||. . . ||||||||. ||.|||||.| .....|||.|
lkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmlt
KLKERNETKCERYWPDPTFRMQEkYGDIVVTFDSALG--RDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdRDDGKTG
.| |.. ||..|||. . .. |||..||. | |.| .. | ... .. .|...|..|| |||||||.||..||.....|. .. . . |
elvelgrekcaqywpleegeslt.ygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl.kllpsgg
PVVVHCSAGIGRTGCFVATSIGIKQIQ---KENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
||.||||||.||.|.|.| . . |.. ||..||||..|. .|. | |.|.| .||.|.|.||....
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
|
|||||||||
subfamily_PTPN14_pd | Subfamily PTPN14 | 57-317 | 6.4e-54 | 178.0 | In-house | 23-295 (300) | alignment | ||
Range on Protein: 57-317
Range on HMM: 23-295/300.0
KQLYAEFWEIPMNHPPAE---ERLPGSSYRNRYPSILPNSRTRVSLPQIPDDpLSSYINANVLK-GYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPII
....|. .|| .. |. .|| .||.. .|| .|| | .. . |||| .| | . .|..|||| ||.|||.|.| .. .|
gkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqli
VMITKLKERNETKCERYWPDPTFRM-QEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDG
||.|. .| .|. .|.|. . . . ..| || | . |.| . | |. | ..| || |||||||. ... |. ..||. . . .
vmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktns
K------TGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
. ||.||||||.|||| . . . |. .......|| |.. .| | .|.| .||.|||..| ..
eveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 57-242 | 3e-37 | 123.0 | In-house | 5-192 (319) | alignment | ||
Range on Protein: 57-242
Range on HMM: 5-192/319.0
KQLYAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMIT
.... || ..| |.| ..| ..|. ..| ||| |..|.||. . |..|. ..|| . | .||.| .| . ||||..| .|| .|
edvaeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt
KLKERNETKCERYWPD-PTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYtAWPDHGVPDSPRQLLQLVDEVHL
.| | .| .|.| | .. |||| ||. .| | |..| . . . | | |||| |.. .|| ... |. .. ||.
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
|
|||||||||
subfamily_PTPN1_pd | Subfamily PTPN1 | 58-314 | 5.5e-52 | 171.3 | In-house | 10-267 (290) | alignment | ||
Range on Protein: 58-314
Range on HMM: 10-267/290.0
QLYAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDdplsSYINANVLKgYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITK
..| . . ..| .| .|| .||| . | .|. | . ||||.... | .| |||||. ||. ||.|.| ... .||. |
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk
LKERNETKCERYWP--DPTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDgKTGP
. |....|| .||| . . .. . . |.. | .. |.. | . .| | ..|. ||.||| |||.|| ..|... .| . . . ||
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss.dvGp
VVVHCSAGIGRTGCFVATSIGIKQIQKENK---VDILKIVCGMRMERGGMVETDSQYEFVYRAL
.|.||||||||.| |. . .|.|... ||| | .. .| | |.. | | .| | |.
avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
|
|||||||||
subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 58-317 | 2.5e-37 | 123.5 | In-house | 17-276 (307) | alignment | ||
Range on Protein: 58-317
Range on HMM: 17-276/307.0
QLYAEFWEIPMNHPP--AEERLPGSSYRNRYPSILPNSRTRVSLPQipDDPLSSYINANVLkGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMI
.| || .. | . | . . .||| . ..|. . | | || || | | . . ||..|||| |. .|| |. .. ..|.
alvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkf..dglasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesviml
TKLKERNETKCERYWPDPTF---RMQEKYGDIVVTFD--SALG--RDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlaqdrdd
|. | . |||.||| . |. | |. | | ..|.| . .| | . |. .. |||.|||. . |.. |.
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr.......
GKTGPVVVHCSAGIGRTGCFVATS-IGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
..| |||||||||.||.| || | . | |. .| |. |.| .| .| ..|. || ...| | ..
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 59-316 | 4.9e-89 | 294.5 | In-house | 25-279 (564) | alignment | ||
Range on Protein: 59-316
Range on HMM: 25-279/564.0
LYAEFWEIPMN--HPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMIT
. |. .| .. .. . . | .||| |.. ..|| | ... |. | ||||. ..|| . .|.|||||||. |..|||||.| ... .|||.|
feeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmlt
KLKERNETKCERYWPDPtfRmQEKYGDIVVTFDSALGRDGYQITSLYIS--HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdRddGKTGPV
||.|....||..|||. . .|.||...||. . |.|... .. .|.. | .. .|.|||||||.|...||.|...|. .. . ..||.
kleEkgkvkchkYWPek..g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e..pdagPi
VVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
|||||||.||||.|.. .. ...|..|..||| ..| .| .| ||.| .|| |...|...
vVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaile
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 59-318 | 3.2e-86 | 284.5 | In-house | 2-274 (284) | alignment | ||
Range on Protein: 59-318
Range on HMM: 2-274/284.0
LYAEFWEIPMNHPP-----AEERLPGSSYRNRYPSILPNSRTRVSLPQIPDD-PLSSYINANVLKGYG----EEINAFIATQGPLSCTVNDFWRMIWYHH
|..||.|.... .. .|| .|||..|||. ..|| | ...| . |.||||. ..||. ..||||||||. ||.|||||.| ..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn
CPIIVMITKLKERNETKCERYWPDPtfRMQEKYGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQD
...|||.|.| |.. .||..|||. .|||. ||. | .|.| .. |.... .. .|...|..||.|||||||.||..||.....|. ...
vrvIVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle
RdDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKEN---KVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
. .. ||.|||||||.||||.|.| . ..|..||. .||.|..|. .|. | |||.| .||.|||.||....
n.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
|
|||||||||
subfamily_PTPRB_pd | Subfamily PTPRB | 60-319 | 7.7e-79 | 259.8 | In-house | 31-286 (293) | alignment | ||
Range on Protein: 60-319
Range on HMM: 31-286/293.0
YAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLK
| |. .. ... . .|. . .||| ||| .|| | .. |.. | ||||| ..|| . . |||||||| ||.|||||.| ... ||||.|.|
yeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp.refiatqGPlpetvddfWrmvwekkssiivmltqlv
ERNETKCERYWPDPtfRMQEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrDDGKTGPVVVHCS
|. .|||.|||. . . |||| ||. . . . | .| |..... |.. .| .|.|||||||.....||..| .|. |.. .. ...|.|||||
ekgkvkCeeYWPad..eepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaie.ktaskrPivvhCs
AGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHWR
||.|||| |.| ...|..|. |||. ||. .|.|| .| | .|| |..... . .|
aGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
|
|||||||||
subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 60-316 | 6.9e-66 | 217.2 | In-house | 21-274 (281) | alignment | ||
Range on Protein: 60-316
Range on HMM: 21-274/281.0
YAEFWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLK
|... .| .... . . .||| | ||| . . .. . ||||| ..|| .| ...||||||. ....||.|.| .. .|||.|.
yeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykge.keyiatqgPvPaslvafWqmvweqkvsaivmvtrei
ERNETKCERYWPDPTFrmQEKYGDIVVTFDSALGRDGYQITSLYI-SHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDGktGPVVVHC
| . || |||||.. . ||||..|.. .. . | . . .| .|.. . ||||||||||.....||. .||. ..... |.|.||
eagklkChrYWPddns..elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk..aplvihC
SAGIGRTGCFVATSIGIKQIQ-KENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
|||.||||...| .|... .....|. .| .| || || | ||||||.|. .
saGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 61-318 | 2.3e-79 | 262.1 | In-house | 27-277 (278) | alignment | ||
Range on Protein: 61-318
Range on HMM: 27-277/278.0
AEFWEIPMnHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKE
|..... . .|| . .|||..|||. ..|| | .. |. |.||||. ..|| . ||||||||. ||.|||||.| .....|||.|.|.|
eellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvttivmLtelve
RNETKCERYWPdptfRMQEKYGDIVVTFDSALGRDGYQITSLYIS--HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddGKTGPVVVHC
.. .|| .||| . ..|||..||. . |.| .. | .. . .| .||.|..|||||||.|. .||... .|. |.. . |||.|||
lgrvkcaqYwp....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale...dsngpvlVHC
SAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
|||.||||.|.| . . |..|| .||....|. .|. |.|.|.|.|||.|.|.||....
saGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 62-319 | 6e-60 | 197.7 | In-house | 24-280 (315) | alignment | ||
Range on Protein: 62-319
Range on HMM: 24-280/315.0
EFWEIPM--NHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLK
|| ..| .. | . .||| ||| ..|| | | |.| | |||| .|.. .. .|.||.|||| ..|.|||||.. .. |||.||..
efhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkq
ERNETKCERYWPDPTFRMqEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAqdrDDGKTGPVVVHCS
| . || .|||| ..| | |. | . . | . .|.. |.. . .| |||.||. ||.|. || .. |. ...||||
egdkikcrqywPdrkads.vefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad...ngkkefsllvhcs
AGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL--YHHWR
||.|||| ... ..||.... ||....| .| .| .| |. .| |.| |. . .||
aGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 63-315 | 3.8e-70 | 231.3 | In-house | 25-287 (297) | alignment | ||
Range on Protein: 63-315
Range on HMM: 25-287/297.0
FWEIPMNHPPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERN
. |.. .|.. . .||| .| .||| |.....|. | ||||| . || .. .||||||||| ||.|||||.| ... .|||.|.. ||
irnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqk.kafiatqGplkktvsdfWrmvWeqevlvivmttrvverg
ETKCERYWPDPTfRMQEKYGDIVVTFDSALGRDGYQITSLYISHS--QSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQ--------DRDDG--K
|| .|||. . ....||. |. . .. |....| |... . |.. |. ...|||.|||.| .||.....| .| |.. | .
rlkcgqyWplee.essaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghps
TGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|.|||||||||||| |.. | .........||. . | .| | .. |. |||| | |.
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 66-315 | 4.7e-51 | 168.8 | In-house | 32-285 (325) | alignment | ||
Range on Protein: 66-315
Range on HMM: 32-285/325.0
IPMNHPPAEE--RLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKErNE
.| . . | . .| .||.. ... ..|| | ||| | ||||. |. . . . |.|.| ||. |.||.||.. .|...|.. .|.. ..
lpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrdd.kkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldl.gk
TKCERYWPDPTfRMQEKYGDIVVTFDSALGRDGYQITSLYISHSQSP--RRLYHYWYTAWPDHGVPDSPRQL---LQLVDEVHLAQDRDDGKTGPVVVHC
.| |||. ..| . | . .. | | . . | . . . .|.| ||. | | ||||..|. . ..|..|||
drcavywpkem.gksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc
SAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|||.|||| |.. .... .| .|||.. | .| .| |||| || ..| ||
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealv
|
|||||||||
0049772 | (Phosphotyrosine protein) phosphatases II | 67-317 | 3.7e-44 | 147.1 | In-house | 33-279 (314) | alignment | ||
Range on Protein: 67-317
Range on HMM: 33-279/314.0
PMNHPPAEERLPGSSYRNRYPSILPNSrTRVSLPQIPDDPlSSYINANVLKGYgeeiNAFIATQGPLSCTVNDF----------WRMI--WYHHCPIIVM
. .. .|. .|||. ||| .|| || | . |.||||. ..|. ..||||||||..||.|| |||. . ... .|||
lpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm
---------------------ITKLKERNetkcerywPDPTFRMQEKYGdivvtfdsalgrdgyqitSLYISHSQSPRRLYHYWYTAWPDHGVPdSPRQL
...| ... . ||.. .| . . . ... .|. ..|... .||...| .....
srdevladelsrLdaAlgKtpllildgng........neptaadlellk..................eelydpelferlgikylripvpDgsap.lledf
LQLVDEVHLAqdrddGKTGPVVVHCSAGIGRTGCFVATSIGIKQIqkenKVDILKIVCGMRMERG-----GMVETDSQYEFVYRALYHH
..... .. | | |||.|||.||.||||.||.. . .|. .|.. ... .|. | |..|. ||||...||...
deflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
|
|||||||||
DSPc_SM00195 | 71-316 | 2.6e-82 | 271.5 | In-house | 17-260 (263) | alignment | |||
Range on Protein: 71-316
Range on HMM: 17-260/263.0
PPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYW
. |.. . .. .||| |||. .||| |....... |.|||||..||. .. ...|||||||. ||.|||||.| ....||||.|. .|....||.|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw
PDPTfRMQEKYGDIVVTFDSALGRD-GYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgkTGPVVVHCSAGIGRTGC
|. .|..|.| |.. . .. .... | ... . .|....|.|..|||||||||....|.|. .|. ... .||.|||||||.||||.
pees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgt
FVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
||...| ......|.|||| .||. .|..| |||.|. || |.|.|. .
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
|
|||||||||
PTPc_SM00194 | 71-316 | 2.6e-82 | 271.5 | In-house | 17-260 (263) | alignment | |||
Range on Protein: 71-316
Range on HMM: 17-260/263.0
PPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYW
. |.. . .. .||| |||. .||| |....... |.|||||..||. .. ...|||||||. ||.|||||.| ....||||.|. .|....||.|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw
PDPTfRMQEKYGDIVVTFDSALGRD-GYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgkTGPVVVHCSAGIGRTGC
|. .|..|.| |.. . .. .... | ... . .|....|.|..|||||||||....|.|. .|. ... .||.|||||||.||||.
pees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgt
FVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
||...| ......|.|||| .||. .|..| |||.|. || |.|.|. .
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
|
|||||||||
subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 71-316 | 4.1e-43 | 142.3 | In-house | 36-234 (392) | alignment | ||
Range on Protein: 71-316
Range on HMM: 36-234/392.0
PPAEERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNetkceryw
| . . . .||| ||| ..|| | | | | | |.|| .... | .|.||.||| .....|||||.. .. |.|.||||| .
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........
pdptfrmqekygdivvtfdsalgrdgyqitslyisHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLaqdrDDGK-TGPVVVHCSAGIGRTGCFV
. .. | . .| |||..|| ||... ||. | |. | |...|||||.|||| .
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevka....dfGqythpliihcsagvgrtgvvi
ATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
. . . .| ||....| .| .| ||.|. || |.| |.
sidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 74-319 | 1.8e-74 | 245.9 | In-house | 27-273 (278) | alignment | ||
Range on Protein: 74-319
Range on HMM: 27-273/278.0
EERLPGSSYRNRYPSILPNSRTRVSlpqipddplsSYINANVLKGYgEeiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDp
. ..|. ..|||..|||. ..|| ||||. ..|| ..|||||||| ||.|||||.| .....|||.|.|.|.. ||..|||.
palylgnldknRykdilpydhsrVk..........dYINAsyidgy.p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.
tfRMQEKYGDIVVTFDSALGRDGYQITSLYISHS------QSPRRLYHYWYTAWPDHGVPDSP--RQLLQLVDEVHLAQD----------RDDGKTGPVV
. . |||..||. | | | .. |.. . .| ..|..|. |||||||..| ...|.|..... |.. . ... |||.
..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl
VHCSAGIGRTGCFVATSIGIKQIqkENKVDILKIVCGMRMERGG-MVETDSQYEFVYRALYHHWR
||||||.||||..|| . .... |..||.|..|. .|. |.| .|.. .||.|.|..|.....
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 74-315 | 1e-62 | 206.6 | In-house | 35-272 (280) | alignment | ||
Range on Protein: 74-315
Range on HMM: 35-272/280.0
EERLPGSSYRNRYPSILPNSRTRVSLPQIPDDplssYINANVLKG--YG-EEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYW
. |.| .||| ||| |||.| . . | ||||| .. . . .| .|||||||. |..|||.|.| ... .|||.| | || .|| .||
aarkpenlsknryrdilpydatrvklkesetd....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW
PDPTFRMqeKYGDIVVTFDSALGRDGYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdrdDGKTGPVVVHCSAGIGRTGCF
|... .. .||.. |. . . | . |...... |.. . |.|||||||||.. ..|..|..|. .. ||. |||||||||||||| .
Petedel..eygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr...sgkeePvvvhCsaGigrtGvl
VATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
.. . . |.....| .|.|| || |. .|.| |||.|| |.
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 75-318 | 5.3e-76 | 250.8 | In-house | 6-246 (249) | alignment | ||
Range on Protein: 75-318
Range on HMM: 6-246/249.0
ERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDpt
.|| . .||||.|||. ..|| | .|. .||.||||....|| . ||||||||. ||.|||||.| ... .|||.|.|.|.. ||..|||.
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..
fRMQEKYGDIVVTFDSALGRDGYQITSLYIS--HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdGKTGPVVVHCSAGIGRTGCFVATS
. .|||..||. | |.| .. |... ...|. .|..|| |||||||.|. .||.....|. |.... .| |||.||||||.||||.|.|
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaay
IGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
. . |..||..||.. .|. .|. |.|.|....||.|.|.||....
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 75-315 | 6e-73 | 240.4 | In-house | 42-276 (288) | alignment | ||
Range on Protein: 75-315
Range on HMM: 42-276/288.0
ERLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPT
||. .|||. ||| .|| | . .. . . ||||. ..|.... ...||||||| ||||||.... .. |||.|.| |...||||.||||
grlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk.kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdad
frMQEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgkTGPVVVHCSAGIGRTGCFVATSIG
...||.. || . . . .| . .... ... .| |.||||||||.| ..||.|.. |. |.. | |||..||||||.|||| |.|
..kpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdal
IKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|.....|...|.. .|. .|..| .|.| .||||.|..|
idaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 76-315 | 5.1e-78 | 257.3 | In-house | 42-277 (318) | alignment | ||
Range on Protein: 76-315
Range on HMM: 42-277/318.0
RLPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptf
| ..||| ||. .||| | .. ... | ||||| . || .. .|.||.|.||. |..|||||.| .. .|||.|...|| .|..||||.
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrk.kayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs...
RMQEKYGDIVVTFDSALGRDGYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDgkTGPVVVHCSAGIGRTGCFVATSI
. ..||..||. .. . . | . .. ..... . | | ||.|||.|||.|. .||.|| .|. || . . .||.|||||||.|||| |.| .|
kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg..agpivvhCsaGvGrtGvfiavdi
GIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
...|..|. ||....| .| .| || |..||||.| .|
llerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvll
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 76-314 | 1.1e-43 | 144.2 | In-house | 29-291 (297) | alignment | ||
Range on Protein: 76-314
Range on HMM: 29-291/297.0
RLPGSSYRNRYPSILPNSRTRVSLPQIPDDplSSYINANVLKGYGEEIN-AFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPT
. ..| .||| || ||| | . . . . ||||. . || . .| .||||| ||.|||.... . .|||..||.| || |||.
krnsslrknryrdilatddtrvkllrvite..rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv
fRMQEKYGDIVVTFDSALGRDgY---QITSLYISHSQSPRRLYHYWYTAWPDHGVP----DSPRQ-------------LLQLVD----EVHLAQ---DRD
. | ||.|| | | . . ..| | . . . | . | . .||||||| | | .| ||. | | .
.qerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslrae
DGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
. ...||||||.||.| | . . .....|. |. |. .| .| .|.| |.|..| |
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
|
|||||||||
subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 76-315 | 4.8e-33 | 109.0 | In-house | 33-266 (281) | alignment | ||
Range on Protein: 76-315
Range on HMM: 33-266/281.0
RLPGSSYRNRYPSILPNSRTRVSLPQ-IPDDPLSSYINANVLKGYGEeINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPT
| .||| | .|| | .|. . || || .. .| |||| | ||||||| |||. .. | | || |.| .
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspfl.krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna
FRmQEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlaqdrddGKTGPVVVHCSAGIGRTGCFVATSIG
.. . |... . | | .|. | . |. . ||| ||.| .|... ... .. | |.|||||.||.| ..| |
hc.clqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir.......arstppvihcsagvgrsgtlmaveia
IKQIQKENK-VDILKIVCGMRM-ERGGMVETDSQYEFVYRALY
.. |. || .|| .|. | |.| || .... |
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 77-317 | 4.3e-74 | 244.3 | In-house | 6-242 (245) | alignment | ||
Range on Protein: 77-317
Range on HMM: 6-242/245.0
LPGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEeINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfR
|| . .|||..|||. .||| |. .. |. |.||||. .|| . ||||||||. ||.|||||.| ... .|||.|.. |.. ||..|||. .
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyri.tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...g
MQEKYGDIVVTFDSALGRDGYQITSLYIS--HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddGKTGPVVVHCSAGIGRTGCFVATSIG
.|||..||. | |.| .. | .. . .| .||.|. ||||||||....||.....|. |. . .. |||.||||||.||||.|.| .
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylm
IKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
. |..|| .|.. ..| .|. |.|.|.|.|||.|.|.||...
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 77-317 | 6.5e-71 | 234.0 | In-house | 7-241 (243) | alignment | ||
Range on Protein: 77-317
Range on HMM: 7-241/243.0
LPGSSYRNRYPSILPNSRTRVSLpqipDDplSSYINANVLKGYGeeiNaFIATQGPLSCTVND----FWRMIWYHHCPIIVMITKLKERNETKCERYWPd
|| . .|||..|||. ..|| | .. |.||||| .... . .|||||||. ||.| ||||.| ... .|||.|.|.|.. ||..|||
lpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtp...r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.
PTFrmqeKYGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDR-----DDGKTGPVVVHCSAGIGR
.. |||..||. | |.| .. |.... .. .| .||.|..|||||||||| .||...|||. ... . . |||.||||||.||
gev....tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR
TGCFVATSIGIKQIqkenKVDILKIVCGMRMERGG-MVETDSQYEFVYRALYHH
||...| . .... .||....|. .|. |.| .|.| |||.|.|.||...
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 78-316 | 1.2e-76 | 252.9 | In-house | 46-281 (319) | alignment | ||
Range on Protein: 78-316
Range on HMM: 46-281/319.0
PGSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFrm
. . .|||. ||. |||| |..... . | ||||. . || |. ..|||||.||. |..|||||.| ... |.||.|||.|. . |...|||. .|
eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenf..
qEKYGDIVVTFDSALGRDGYQITSLYISHSQS---PRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgKTGPVVVHCSAGIGRTGCFVATSIG
|.|| ..|| .. ..| | | . . .| |.. |. ||.||||.||.. ..||.|. ... .... . ||.|||||||.|||| |.. ..
.eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrekt..qsgPivvhCsaGvGRtGtfivldam
IKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
. ....|. .|. ..| .|. | ||.. .||.|.| || .
lervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 78-315 | 9.6e-67 | 220.4 | In-house | 45-284 (563) | alignment | ||
Range on Protein: 78-315
Range on HMM: 45-284/563.0
PGSSYRNRYPSILPNSRTRVSLPQIPDDPLS-SYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfR
| . .||| .|.. |.||.| ..|. . ||||| ..|| . .||||||||| |..||||||| .. ||||||.|.||. ||..|||
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqks.kafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk...d
MQEKYGDIVVTFDSALGRDGYQITSLYISH------S--QSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddgKTGPVVVHCSAGIGRTGCF
|.|| . || . |.. .| | . . .. .. ..| || |||||||... |. | |. . ..||.|||||||.|||| .
esetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka...eaGPivvHcsaGvgrtGty
VATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
.. . .||||.||.|...... .|..| .|.| || |.. ||
ivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 78-315 | 2.3e-57 | 189.1 | In-house | 44-280 (290) | alignment | ||
Range on Protein: 78-315
Range on HMM: 44-280/290.0
PGSSYRNRYPSILPNSRTRVSLPQIPDD--PLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPtf
. .. .||. |... |. | .|... .|||| .||| |. ...||||||.| |. |||..|| ....||||.|. .| ...|| ||||
ssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..
RMQEkYGDIVVTFDSALGRDGYQITSLYISHSQS---PRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdRDDGkTGPVVVHCSAGIGRTGCFVATS
.. || . .. . ..| .. | . ...| .. . .| |.|...| | |... |. | | .| ...|||||...||.. |.|.
dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktq.rkrg.ntsivvHCSdtvgrsavfcaaa
IGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
..|.. ..| .|..... .|. . |.|.| ||..... .
ttinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivl
|
|||||||||
subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 78-188 | 8.7e-11 | 35.9 | In-house | 94-195 (244) | alignment | ||
Range on Protein: 78-188
Range on HMM: 94-195/244.0
PGSSYRNRYPSILPNSRTRVSLPQipDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNEtkcerYWPDPTfRM
| .|..|| . || || | . .|||| . | .| || ||. | |||.|. | ..|.. ..| .| |||| .
pnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrt.aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdse.pl
QEKYGDIVVTF
. || ||.
ewyeeditvtl
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 79-314 | 4.9e-67 | 221.3 | In-house | 55-286 (298) | alignment | ||
Range on Protein: 79-314
Range on HMM: 55-286/298.0
GSSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfRMQ
.|||..|.. .|| | .. .| | |||| |..| .. |||||||.|| ||.|||||.. .. |||.|.|.| ..||...|||| . .
enkkkNRyadiialdssRvvLekedadeesdYiNAsflhay.kgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPd...egk
EKYGDIVVTFDSALGRDGYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLaQDRDDGkTGPVVVHCSAGIGRTGCFVATSIGIK
|.||.| |. | . .. | .|... . |.. . .| |||.||| . .|.|...|. . .. | ||.|.||||.||.| |.| . .
etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqag.nkpvivqCsaGvgRsGtfiaidsvle
QIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
...||..||....| .|..| |.|.| .|| |.| |
rvkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeav
|
|||||||||
subfamily_PTPN12_pd | Subfamily PTPN12 | 80-316 | 2e-71 | 235.3 | In-house | 40-275 (290) | alignment | ||
Range on Protein: 80-316
Range on HMM: 40-275/290.0
SSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEInAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQE
.||| ||| .|| | .| ... |.|||||..|| ... ..||.||||. |..|||||||... |.||. .. | . .|||||||. . ..
nvkknrykDilPydksrvelskieeeegsdYinanfikgvegkl.eyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg.eeel
KYGDIVVTFDSALG-RDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddGKTGPVVVHCSAGIGRTGCFVATSIGIKQI
..|.. || .. |.. | .| . ... |..| . |||||||||| |. .||.|...|. |. . |.|||||||.|||| .| . ...
efgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrell
QKENK---VDILKIVCGMRMERGGMVETDSQYEFVYRALYH
..|. .|. ..| .| .| .| | |||.||.|. .
kaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 80-315 | 1.4e-50 | 167.0 | In-house | 45-276 (439) | alignment | ||
Range on Protein: 80-315
Range on HMM: 45-276/439.0
SSY---RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNEtkcerYWPDptfR
.| .||| .. . ||| | .|| | | ||||| .||| .. . .|||||| |..||||... ... |||.|.| | |||
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyydd.klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps...d
MQEKYGDIVVTFDSALGRDGYQITSLYIS----HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDgkTGPVVVHCSAGIGRTGCFVATS
. ||||.| | . | | . . ... | . .. |.||||. || .|... . |.|... .||||||||||.|||| .|
aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkee..ygpvvvhcsagvGrtGtiiald
IGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
| ..|.. |||||| || .| .| ||.. || |.| |.
ialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
|
|||||||||
subfamily_PTPRN_pd | Subfamily PTPRN | 80-314 | 2.3e-47 | 156.1 | In-house | 56-288 (297) | alignment | ||
Range on Protein: 80-314
Range on HMM: 56-288/297.0
SSYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQE
.||. ..|| .||.| . .. | |||| .. |.|||||||. || |||.|.| . . .||..|.|.| . ..|.||||| . .
nvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyh
KYGDIVVTfdSALGRDGYQITSLYISH--SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdrdDGKTGPVVVHCSAGIGRTGCFVATSIGIKQ
| .|. . | | . |.|. .. | . . . .||..||| |.. ||.. | . |.. |.|||||.| ||||.... . ...
iyevhlvs..ehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksy...rGrscpivvhcsdGaGrtGvyilidlvlnr
IQKE-NKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
..| ...|| . .| .| |.|.| .|.||.. |.
llkGvkeidiaatlehlrdqrpglvktkdqfefaltav
|
|||||||||
subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 80-316 | 2.5e-30 | 100.5 | In-house | 43-269 (288) | alignment | ||
Range on Protein: 80-316
Range on HMM: 43-269/288.0
SSYRNRYPSILPNSRTRVSLPqipDDPlSSYINANVLKgYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQe
.. |.|| . ||| | ||| ||.|||. .. . .| .| || |.. .|.|. |||...| |. | . |.| .
nptrdryenlprcditrvkls...ddp.dfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka.
KYGD-IVVTFDSALGRD-GYQITSLYISHSQSPRR-LYHYWYTAWPDHGVPDSPRQLLQLVDEVhlaqdrdDGKTGPVVVHCSAGIGRTGCFVATSIGIK
..| |. .. . | ... | ||. . . . . |.|.|||.. |.|.. . . |.|||.|||.|||| .. . | ..
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlililiale
QIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
... .. . | ... .| || ..| || .|.| ...
slrlddflgirsllaklreerfkaiqtemqylyvhrcvle
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 81-318 | 1.7e-78 | 258.4 | In-house | 21-264 (270) | alignment | ||
Range on Protein: 81-318
Range on HMM: 21-264/270.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFR-MQE
. ||| |||. .||| |... .|. . ||||| ..|. .| ...||..||| |...|||||| .. . |||.|.|.|.. .||||||| . . ..
kklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl
KYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPR------QLLQLVDEVHLAQDRDDGKTgPVVVHCSAGIGRTGCFVATSI
..|.| |. | ..|| .| | . .. . ||| |.||..||||||| .. |||... .|. ... | .. |..||||||.||||...|. |
edgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDi
GIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
... .....|||.|.|. .| .| .|.. ||||.|.|. ..
avrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
|
|||||||||
subfamily_PTPN6_pd | Subfamily PTPN6 | 81-318 | 4.9e-72 | 237.5 | In-house | 55-297 (306) | alignment | ||
Range on Protein: 81-318
Range on HMM: 55-297/306.0
SYRNRYPSILPNSRTRVSLPqIPDDPLSSYINANVLKG-YGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfrMQE
.||| .||| |||.| |. | | |||||..|. .. ...||||| |. ||.|||||.| .. .|||.|| ||.. || ||||| . ..|
keknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee..eke
KYGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDD-GKTGPVVVHCSAGIGRTGCFVATSIGI
.||.| || | . |.. .| .|. ... |....| ...||||||| .| ..|.....|. |.. ..||.|||||||||||| |. . | .
eyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDill
KQIQKE---NKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
|.|.|. ..|| |.| .| | |.| |..|| |||.|. ..
kliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 81-316 | 6.2e-71 | 234.0 | In-house | 49-284 (307) | alignment | ||
Range on Protein: 81-316
Range on HMM: 49-284/307.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEeINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPtfrMQEK
.|||. | . .||| |..|. . |.||||. .||| | . ||| |.|. |..||||||. . .|||...|.| |. ||..|||. . .
alknRyedikafDktRvkLkkingkedsdYinasfikgyke.kkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...devq
YGDIVVTFDSALGRDGYQITSLYISHSQ-------SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgkTGPVVVHCSAGIGRTGCFVATSI
||||.|.. | . | | .|..|. . |.. | ||.|.| ||...| ||.|...|. . . .|.||||||| ||.| ||| ..
ygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln...rsPivvhCsaGvgrsgifvalds
GIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
..|...|.|||| ..|...| .| .|. ||.|.||||
llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralld
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 81-315 | 2.3e-64 | 212.0 | In-house | 10-239 (250) | alignment | ||
Range on Protein: 81-315
Range on HMM: 10-239/250.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETkCERYWP-DptfrMQE
.||| |.. .|| | . | | |||| |.|| |. .|||||||||. |..|||||.. .. |||.|.||| ..| ...||| . |
keknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve....kae
KYGDIVVTFDSALGRDGYQITSLYISHSQSP--RRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddGKTGPVVVHCSAGIGRTGCFVATSIGIKQ
||||. |. | |... | .|. . | . .. ...||| |||. . |.|...|. |.. ...||.|.||||.||.|.|.| . ...
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq..agnaPvivqCsaGvgrsGafiaidavler
IQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
..||..||. |.. .| .| ..||. .|| |||...
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiil
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 81-315 | 2.7e-61 | 202.2 | In-house | 50-276 (315) | alignment | ||
Range on Protein: 81-315
Range on HMM: 50-276/315.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPtfrmQEK
.||| |.. ..|| || . || | |.||| ..|| . . .||.|||. .|.||||... ... |||.|.| |... |.|.|||| .
kqknryiniiaydksrvqlpllendphsdyvnanfidGynkk.rryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk....kvi
YGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdrdDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQK
|| | || | . | . .| . . | .. . ||.||| ||| . |..|. |. . . . |..|||||||.|||| |.. . ..|..
yGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh...tnsvgaivvhcsaGvGrtGtfitldavldqaea
ENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|| .|. ... |.| | .||.. ||.|.| ||
enaidvynfitgvrqnrikmvqvaeqyqfiydall
|
|||||||||
subfamily_PTPN23_pd | Subfamily PTPN23 | 81-319 | 1.2e-59 | 196.5 | In-house | 44-281 (288) | alignment | ||
Range on Protein: 81-319
Range on HMM: 44-281/288.0
SYRNRYPSILPNSRTRVSLPQIPDDplssYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEK
| .||. ||| ..|| | . || |||| ..|. |||||.|| |.||||.|.. . ..|||... .|....|..|||| . .|
seknrsrdilPyDhnRvklrgskDD....YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk.getvk
YGDIVVTFDSALGRDGYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDR--DDGKTgPVVVHCSAGIGRTGCFVATSIGIK
.||. || | . . | ... . . . | .|.||..|||.|| .|||..|||. | . || |.|||||||.|||| | ..
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.PlvvhCsaGvgRtgvfalvyaavr
QIQKENKV-DILKIVCGMRMERGGMVETDSQYEFVYRALYHHWR
...|.| . ||...| .| .| ||.. .|..|.| | .. |
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 81-316 | 6.1e-59 | 194.8 | In-house | 26-253 (284) | alignment | ||
Range on Protein: 81-316
Range on HMM: 26-253/284.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITklkernETKCERYWPDptfRMQEK
.||. ||. ...| | .. | |||| ..|| . . .||||||| |..||||||| ..| ||..| . || .||| ....|
kdknrighilafdknvvklerliGeefsdyinasfitGyqrk.dkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl...kivik
YGDIVVTFDSALGRDGYQITSLYISH---SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDE-VHLAQDRDDGKtgPVVVHCSAGIGRTGCFVATSIGIK
.. | || . | . .. .|. . |.. . . |||.||||.| .|..||. || . .. . ..|||||||.|||| ... . ..
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhra..nivvhcsagvgrtgvyivldvlld
QIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
....|..||. ..| ..| .| .|. || |.| ||
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
|
|||||||||
subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 81-316 | 3.7e-50 | 165.3 | In-house | 39-275 (287) | alignment | ||
Range on Protein: 81-316
Range on HMM: 39-275/287.0
SYRNRYPSILPNSRTRVSLPQIPDDPlSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQEK
.||| .|| ||| | . .. |.||||| . .| .. .||||.|||...||.||||... .. ....|. | || .|||.. |.
vkknryadvlPiddtrvllsaegelG.sdyinanyvasytdd.eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG
yGDIVVTFDSALGRDGYQITSLYISHSQSPR-RLY-HYWYTAWPDHGVPDSPRQLLQLVDEV--HLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIK
| || .| | . .| . . .. |. . . .|||.... . |...| .| |. || ..||.|||...||||.| ..|| . ..
.GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs
QIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
. .. .||. ..| .|. | ..| . |. ..| ||
rledlGrvdvaavvirlreyraalvqavvqlrllyealvt
|
|||||||||
subfamily_ptpA1_pd | Subfamily ptpA1 | 81-280 | 1.9e-38 | 127.3 | In-house | 48-258 (418) | alignment | ||
Range on Protein: 81-280
Range on HMM: 48-258/418.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPT----FR
. .||| ||| .||| | .| | | ||||| . | . ||.||||| |. |||||.| .| ||||... | ||.||||. |
tsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga..ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs
MQEKYGDIVVTFDS----ALGRDGYQIT--SLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDR---DDGKTGPVVVHCSAGIGRTGC
. . ... |. . .| . .. | . .| | |||| .|| . . ||. . |.. . |..||||||.||||
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgt
FVATSIGIKQIQK
|... | .|....
fctavimmkkldh
|
|||||||||
subfamily_Sponge-PTP-2_pd | Subfamily Sponge-PTP-2 | 81-236 | 3e-09 | 30.0 | In-house | 28-164 (169) | alignment | ||
Range on Protein: 81-236
Range on HMM: 28-164/169.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINAnvlkgygeeinafiatqgplsctvndfwRMIWYHHCPIIVMITKLKERNETKC--ERYWPDPTFRMQ
.|| . | |.||| | .. .| | |||| |||| .||.. ..|. | | |. .
etknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddknnfwpekedyqlhpavilg
EKYGDIV-VTFDSA----LGRDGYQITSLYI-SHSQSPR-RLYHYWYTAWPDHGVPDSPRQLLQL
| | | . | | | .| |. | |.... .| . |..||. |||.|| .. .|
ewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvghl
|
|||||||||
subfamily_Sponge-PTP2_pd | Subfamily Sponge-PTP2 | 81-236 | 7.5e-09 | 28.6 | In-house | 27-163 (169) | alignment | ||
Range on Protein: 81-236
Range on HMM: 27-163/169.0
SYRNRYPSILPNSRTRVSLPQIPDDPLSSYINAnvlkgygeeinafiatqgplsctvndfwRMIWYHHCPIIVMITKLKERNETKC--ERYWPDPTFRMQ
.|| . | |.||| | .. .| | |||| |||| .||.. ..|. | | |. .
etknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddknnfwpekedyqlhpavilG
EKYGDIV-VTFDSAL----GRDGYQITSLYIS-HSQS-PRRLYHYWYTAWPDHGVPDSPRQLLQL
| | | . | | | .| || | .... ..| . |..||. |||.|| .. .|
ewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvghl
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 82-315 | 2e-76 | 251.9 | Pfam-A | 3-234 (235) | alignment | ||
Range on Protein: 82-315
Range on HMM: 3-234/235.0
YRNRYPSILPNSRTRVSLpqiPDDPL-SSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEK
.|||..||| .||| | ... | |||||..||| | ..||||||||. |..|||||.| ... .|||.|.|.|....||..|||. . . ...
kknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee.eeslt
YGDIVVTFD-SAL-GRDGYQITSLYISHSQSPR---RLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdrdDGKTGPVVVHCSAGIGRTGCFVATSIGI
|||| |. . ..|... | ........ ......||.|||||||.||..||.|...|. . . |.||||||||||.||||.||| .| .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill
KQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
.|...|..||.|.||. .| .| |||.. .||.|.|.|.
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 82-315 | 2e-76 | 251.9 | In-house | 3-234 (235) | alignment | ||
Range on Protein: 82-315
Range on HMM: 3-234/235.0
YRNRYPSILPNSRTRVSLpqiPDDPL-SSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEK
.|||..||| .||| | ... | |||||..||| | ..||||||||. |..|||||.| ... .|||.|.|.|....||..|||. . . ...
kknRykdilpydktrvkl...kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee.eeslt
YGDIVVTFD-SAL-GRDGYQITSLYISHSQSPR---RLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQdrdDGKTGPVVVHCSAGIGRTGCFVATSIGI
|||| |. . ..|... | ........ ......||.|||||||.||..||.|...|. . . |.||||||||||.||||.||| .| .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill
KQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
.|...|..||.|.||. .| .| |||.. .||.|.|.|.
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 82-314 | 1.7e-65 | 215.9 | In-house | 45-273 (314) | alignment | ||
Range on Protein: 82-314
Range on HMM: 45-273/314.0
YRNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfrmqEKY
.||. ||. |.|| | .| .|| | ||||... .| . .|||.||||| ||.||||... ..| |||.|.|.| || .|||. | |.|
eknrsgdilaydrsrvflitidgdpssdyinaalidsy.krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt....evy
GDIVVTFDSALGRDGYQITSLYISH----SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddgKTGPVVVHCSAGIGRTGCFVATSIGIKQ
||| |.. .. . . . ... . | . .. ...||||.|| | . ||.|| .|. |. . |..||||||| ||||.|.| .| .
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldm
IQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
|..|. ||. ..| .| .. |||| || |.| ..
ieregvvdvfnavktlrsrkvnmveteeqykfiydvi
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 82-315 | 8.1e-63 | 207.2 | In-house | 39-266 (273) | alignment | ||
Range on Protein: 82-315
Range on HMM: 39-266/273.0
YRNRYPSILPNSRTRVSLPQIPDdplssYINANVLKG-YGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQEK
.||| .|| .||| | . ||||. .| |.. .||.|||| ||.|||.|.| .. .|.|.|. ||... ||.||||. . .
dknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkv
YGDIVVTFDSALGRDGYQITSLYISHSQS--PRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddgKTGPVVVHCSAGIGRTGCFVATSIGIKQI
.. . |. .||... .| ...|.| |.. | ...||||||| |. .|||.| || |. ..||.||||||||||.| ... . . |
snrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....dagPivvhcsaGiGrsGtlitidvvlgli
QKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
......|. .|| .| | |.| |. || |||.|.
erdkefdvkeivrklreqrqgvvqtkdqyifvykail
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 82-314 | 9.2e-51 | 167.5 | In-house | 49-274 (287) | alignment | ||
Range on Protein: 82-314
Range on HMM: 49-274/287.0
YRNRYPSILPNSRTRVSLPqipdDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFrmqEKY
.||. ||. || | . |||| ..|| |. .|||....|.. |. .||..|. .. ..|||....|| .| .| .|||. . .
dknRltqilvpdnyrvllk....gehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks...vvl
GDIVVTFDSALGRDGYQITSLYISHS---QSPRRLYHYWYTAWPDHG-VPDSPRQLLqLVDEVHLaQDRDDGKTgPVVVHCSAGIGRTGCFVATSIGIKQ
|. ... . .|| . | . .. ...... | .|.|...| |.. || ...| ..| |.| ..|||||...||.. |.| ..|..
GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill.vieemyk.tqrkrgnt.sivvhCsdtvGrsamfcaaattink
IQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
..| .|..... .|. . |.| | .||.|.. ..
ckteGviDvfqvlksqriqkpgsvqtveqykfindiv
|
|||||||||
subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 82-314 | 5.9e-49 | 161.5 | In-house | 35-262 (283) | alignment | ||
Range on Protein: 82-314
Range on HMM: 35-262/283.0
YRNRYPSILPNSRTRVSLPQIPDdplsSYINANVLK--GYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfRMQE
||. |.| . || | . .|||| . .. . .|..|.|| || |||.|.. .. |||.|||.| .. || .||| | |
rknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk...rGse
KYGDIVVTFDSALGRDGYQITSLYISHS---QSPRRLYHYWYTAWPDHGvPDSPRQLLQLVDEVHLAQdrDDGKTGPVVVHCSAGIGRTGCFVATSIGIK
.||. || . . . | | . .. .| | || . | . | .... | .. | | . | ||.|||||.|||||. |.| | .|
dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislq..teskkgPivvhCstgiGrtavfiaasasvk
QIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
... | ||. ..| || .| ..| | || .|. .
daltesvvdvfavvkimreqrmmavqtldqyklvhelv
|
|||||||||
subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 82-314 | 9.3e-49 | 160.8 | In-house | 5-235 (237) | alignment | ||
Range on Protein: 82-314
Range on HMM: 5-235/237.0
YRNRYPSILPNSRTRVSLPQIPDDplSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfrMQEKY
.||| .| .|| | . | ||||. |||. . .||.|||| . .|||.|.| .| .|||.| | |.|| || .|||. . |
iknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd..qpaay
GDIVVTFDSALGRDGYQITSLYISHS---QSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVhLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQI
| . |.. | . || .|. . | .. | .|.|||.|||. ||.. .. . . . ..|| ..|||||.|||| |. ..|
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni.inrsphvsesgpwiihcsagvgrtgiflvidamlrqa
QKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
.... ||| . | . .| ...| || |.....
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti
|
|||||||||
0041856 | (Phosphotyrosine protein) phosphatases II | 82-318 | 4.3e-48 | 158.6 | In-house | 3-171 (182) | alignment | ||
Range on Protein: 82-318
Range on HMM: 3-171/182.0
YRNRYPSILPNSRTRvslpqipddpLSSYINANVLKGYGEEINaFIATQGPLSCTVNDFWRMIWYHHCPIIVMITklkernetkCERYWPdptfrmqeky
.|||. |||. ..| ..|||||.. |. . |||||||| ||.||.||.. ... .||..| .|.|||
dknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........
gdivvtfdsalgrdgyqitslyishSQSPRRLYHYWYTAWPDHGVPDsPRQLLQLVDEVHLaqdrddgKTGPVVVHCSAGIGRTGCFVATSIGIKQiqke
. .| ..|.|. |||||||| ...||....||. . |||.||||||.||||..|| . .|.
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl....
nKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
.|.. ..|. .|. | |||.| .|| |...||....
.gvsleeavklvrsrRpgmvitpnqyfflqlallell
|
|||||||||
subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 82-312 | 1.1e-30 | 101.3 | In-house | 54-284 (310) | alignment | ||
Range on Protein: 82-312
Range on HMM: 54-284/310.0
YRNRYPSILPNSRTRVSLpQIPDDPLSSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPdpTFRMQEKY
..||| .. .|| | .| || || .| ..|| .|||| |. ||||||. . |... | | || ||| .. . | |
hknrysdvvcldtsrvkl.kidksryedyihanyvktny.lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp..slgvtety
GDIVVTFDSAlGRDGYQITSLYISH-------SQSPRR-----LYHYWYTAWPDHGVPDSPrqlLQLVDEVHLAQDRDdgktGPVVVHCSAGIGRTGCFV
| | || | . ..| | .. . | . . ||| |||| . | . ||| | ||.|||||||..|... |
gcirvtnlse.sseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek...chtvpqrllaqvrh....gpcvvhcsagkdrlyvvv
ATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYR
| . |..... .|||. ... .. .| ..|. || .. |
alklkidkldrglkvdaeevktellksraiciqtelqyliidr
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 82-174 | 9.1e-22 | 72.2 | In-house | 49-154 (350) | alignment | ||
Range on Protein: 82-174
Range on HMM: 49-154/350.0
YRNRYPSILPNSRTRVSLPQIPDDP--------LSSYINANVLKGY--GEEINA---FIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCER
.||| ||| ..|| |.. . . . ||||| || . |||. .||||.|| ||.||...| . ..|...|.. | | ||.|
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr
YWPDPT
||.. .
YWqegs
|
|||||||||
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 83-315 | 6.2e-60 | 197.8 | In-house | 54-281 (297) | alignment | ||
Range on Protein: 83-315
Range on HMM: 54-281/297.0
RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEeinAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNEtKCERYWPDPTFRMqekYG
..|| ||| . || | . ||| | |.|| .||. . .|.|| | ||.|||.|.. .. .|||.....||.. || |||.| . .|
ksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt...fG
DIVVTFDSALGRDGYQITSLYISHSQ--SPRRLYHYWYTAWPDHGVPD--SPRQLLQLVDEVHlaQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQI
|..|. | | |. .| ..... . | . | .. |||. |. | ..||.|..||. .| .. . ||..|||.||.|||| ... . ..
dvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevr..kdfsqnaegPllvhclaGvGrtgvlltidsvvaea
QKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
..|..|||...| .| || .| |. ||.||| |.
krekevdifglvkklrqerpylvqtkeqykfvyvavl
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 83-319 | 1.7e-58 | 193.0 | In-house | 46-279 (515) | alignment | ||
Range on Protein: 83-319
Range on HMM: 46-279/515.0
RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPD-PTFRMqeKY
.||| ||| ..|| | | |.| | |.|| .... . .|.||.|||. ..|.||||... .. |.|.||||| . || .|||| |. . |.
knryknilPydsvrvklevindnPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv..kf
GDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddgKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKE
| | | | | . | . ... | . . .| |||.||| . ||.|. || ... | |...|||||.|||| ... . ....
GsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgq...ythpliihcsaGvGrtGvvisidsvvahaktt
NKVDILKIVCGMRMERGGMVETDSQYEFVYRALY--HHWR
. ||....| .| .| .| |. || |.| |. .||
rmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwr
|
|||||||||
subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 83-314 | 5.9e-49 | 161.4 | In-house | 10-236 (239) | alignment | ||
Range on Protein: 83-314
Range on HMM: 10-236/239.0
RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfrmqEKYG
.||| |. ..|| | .. .|| | ||||. |. | .|.||||| .. . |||||.| . .|||.| | | . || .|||| | ||
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst....skyc
DIVVTFDSALGRDGYQITSLYISHS-Q-SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEvhLAQDRDDGkTGPVVVHCSAGIGRTGCFVATSIGIKQIQK
.. ||. . | | .. .|. | | .|.| .| |||.|||. .| | . ...| | . | |.|||||.||||.|. ..| .|
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrk..itkdslpg.arpwvihcsagvgrtgaflvidamlrqakk
ENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
.. |||.. | .| .| ||.| || |.. |.
qktvdifnyvkairedrphmvqtseqyvfihlav
|
|||||||||
subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 83-314 | 6.5e-49 | 161.2 | In-house | 11-237 (239) | alignment | ||
Range on Protein: 83-314
Range on HMM: 11-237/239.0
RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfrmqEKYG
.||| |. ..|| | .. .|| | ||||. |. | .|.||||| .. . |||||.| . .|||.| | | . || .|||| | ||
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst....skyc
DIVVTFDSALGRDGYQITSLYISHS-Q-SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEvhLAQDRDDGkTGPVVVHCSAGIGRTGCFVATSIGIKQIQK
.. ||. . | | .. .|. | | .|.| .| |||.|||. .| | . ...| | . | |.|||||.||||.|. ..| .|
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrk..itkdslpg.arpwvihcsagvgrtgaflvidamlrqakk
ENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
.. |||.. | .| .| ||.| || |.. |.
qktvdifnyvkairedrphmvqtseqyvfihlav
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 83-317 | 1.7e-46 | 153.2 | In-house | 45-289 (296) | alignment | ||
Range on Protein: 83-317
Range on HMM: 45-289/296.0
RNRYPSILPNSRTRVSLPQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNEtKCERYWPDPTfrmQEKYG
.||.. ..| .|| |... . | |||| .. . ...| |..| ||..|||... ... .|..|| . .. .. ||| . .|.||
knrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkk.keyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks...keqyg
DIVVTFDSALGRDGYQITSLYISHS-----------Q-SPRRLYHYWYTAWPD-HGVPDSPRQLLQLVDEVHLAQDRD--DGKTGPVVVHCSAGIGRTGC
.|.| . .| . . . . | . .. .| |. . || | |..|. |.| ... | ..|||||..| | .|.|
eifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGv
FVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
..| . . ...||..||. . | .| .| ..||. .| ..| | ..
ylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
|
|||||||||
subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 83-314 | 8.4e-40 | 131.2 | In-house | 59-279 (290) | alignment | ||
Range on Protein: 83-314
Range on HMM: 59-279/290.0
RNRYPSILPNSRTRVSLPqipDDPLSSYINANVLKGYGeeiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQeKYG
.||| . | .||| | | |. || .|| || |||.| || |.|||. .. |||. .| | .|||.|.|. .. .|
knrykdvvcndktrvilk...dGydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl.tfG
DIVVTFDSALGRDGYQI-TSLYISHSQS--PRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAqdrddgkTGPVVVHCSAGIGRTGCFVATSIGIKQIQ
.| |. .| | | . . .| .|.|. .|||. |. | ||... . | .||||||||||||||| ||| .|.. .
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.......sGpvvvhcsaGiGrtGtfvaievglqill
KENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
. ..|.|..| .| | . |. | || . ..|
dGkeldlldlvralrnsrlnsvqvdiqylalveil
|
|||||||||
subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 83-317 | 8.7e-35 | 115.0 | In-house | 36-258 (267) | alignment | ||
Range on Protein: 83-317
Range on HMM: 36-258/267.0
RNRYPSILPNSRTRVSLPQIPDDplssYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNetkCERYWPdPTFRMQEKYG
|||. || ||| | . .. |||| ..|| . ||||.||.||. |. ||. .| ...|.||..|| . | ..|| | . .||
rnrlddnlpyddtrvilrtkeee....yinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwP.Pkmgqakkyq
DIVVTFDSALGRDGYQITSLYISH-SQSPRRLYHYWYTAWPDHGvpdSPRQLLQLVDEVhLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKE
|..| . . ||| .| . .| . . |.| | . |. . . ||... . |.||.||.|.||.| |. ......|
dltvehslekeendyqiitlelkfknesahnvtlyyykkwnint...nnkpylkplfgi.laknqlengnrPlvvacsdGvGrsGtflvidsqlerakte
NKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
. .|| . . .| | |.|.| .| .... | ..
gvsdifdflrkirsqriglvdtkeryiyihellaey
|
|||||||||
subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 83-309 | 6.1e-33 | 108.8 | In-house | 53-272 (301) | alignment | ||
Range on Protein: 83-309
Range on HMM: 53-272/301.0
RNRYPSILPNSRTRVslpQIPDDPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTF-RMQ-EK
..|||.. . | | .. .| | || .. |. . ||||||||. | .||| |. ... |||... |..|.||| | | . ... ..
khryptvPckPstav...evivdGkrvPihanwiptsGhp.hrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr
YGDIVVTFDSALGRDGYQiTSLYISHS---QSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddgktgPVVVHCSAGIGRTGCFVATSIGIKQ
. ... .. | . .. .| . | ..| . || |. |.|.||| | .| .|.. | ... |.||||||||||. .|..| . ..
fkikiknkelilnkkisk.rtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigteylare
IQKENKVDILKIVCGMRMERGGMVETDSQYEF
.. ...... . . .| .| | | || .
veadptieltealkhlrehrwngvqtnsqlyw
|
|||||||||
subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 83-316 | 9.5e-33 | 108.1 | In-house | 58-287 (305) | alignment | ||
Range on Protein: 83-316
Range on HMM: 58-287/305.0
RNRYPSILPNSRTRVSLPQIPddpLSSYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQEKYG
.||| . . .. | | . . | || || . . ||..|||| |...|| |. .. |||. | | || .||| .| .
knryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks
DIVVTFDS---ALGRDG-YQITSLYISHSQ-SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlaqdrddGKTGPVVVHCSAGIGRTGCFVATSIGIKQ
||| | . || ||| | ...| . | .| ||| ||| |.|. . | |.|||||||||||| || ...
givvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair.......gskvpivvhcsagigrtgtivaieyilek
IQKENKV-DILKIVCGMRMERGGMVETDSQYEFVYRALYH
| ..... . ..| .| .| ...| || |..| .
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
|
|||||||||
subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 83-318 | 1.2e-30 | 101.3 | In-house | 51-287 (305) | alignment | ||
Range on Protein: 83-318
Range on HMM: 51-287/305.0
RNRYPSILPNSRTRVSLpqIPDDPlSSYINANVLKGYgEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWP---DPTFRMQE
.||| . . || | . | || || . . . || || || | ||| | . .. | |. .|.|. || |.. .... ..|
knrykdvgcldnnrvkl..egpwp.heyihanyvstp.tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee
KYGDIVVTFDSALGRDG-------YQITSLYISH-SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLaqdrddgKTGPVVVHCSAGIGRTGCFVAT
| |.| |.|. . . | | | .. |. || . ||| ||| . .|.|. . ||.|||||||||||| |
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp.......skgpivvhcsagigrtgsvvml
SIGIKQIQKENKVD-ILKIVCGMRMERGGMVETDSQYEFVYRALYHHW
..|. .... ||. .| .| ..|| || ||.. . ..
eyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 83-175 | 9.6e-13 | 42.2 | In-house | 51-158 (349) | alignment | ||
Range on Protein: 83-175
Range on HMM: 51-158/349.0
RNRYPSILPNSRTRVSLPQIPDDP--------------LSSYINANVLKGYGEEIN-AFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCE
.||| ||| .|| |.. . . | ||||| || ... .|||| || ||.||...| .... ... || . ||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd
RYWPDPTF
.|| . ..
iywqelsy
|
|||||||||
subfamily_eak_pd | Subfamily eak | 83-227 | 2e-12 | 41.2 | In-house | 55-195 (332) | alignment | ||
Range on Protein: 83-227
Range on HMM: 55-195/332.0
RNrYPSILPNSRTRVSLPQIPDDPLsSYINANVLKgYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEKYG
|| |.|. | | | ..| |||| ... . | . .| | . | ||.|. . | ||.. . | . | ..|.|| | | . |.|
rn.vvkivpydrylvrltssqlnrl.Gyinaslae.fsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt.reelkfG
DIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVP
. |. . . |. .. | .| |..|| . | . .|
ildverkefvkrniletrllelskGnethrvlhykvfGwtettlp
|
|||||||||
subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 84-314 | 1.8e-49 | 163.0 | In-house | 44-289 (301) | alignment | ||
Range on Protein: 84-314
Range on HMM: 44-289/301.0
NRYPSILPNSRTRVSLPQIPD--DPLSSYINANVLKGYGEEiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEKY
||. .| . |. | . |. .||||. ..|| |. ..|||.|||. |. ||||.|| .. |||.|.|||. ..|||.|||. . .|..
nrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnse.aeseef
GDIVVTFDSAL----------------G-RDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDGktGPVVVHCSAGIGR
| . ||. . | .|| . .. .....|.. . . | ||..|| || || .|.| .| . .| ||||||||....|
gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigg..gpvvVHCSdtVsr
TGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
.| ... |||. | . | ||. ... .| . |.| | || ..| ..
sGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
|
|||||||||
subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 84-315 | 2.1e-27 | 90.8 | In-house | 39-267 (285) | alignment | ||
Range on Protein: 84-315
Range on HMM: 39-267/285.0
NRYPSILPNSRTRVSLPQIPDDplssYINANVLKGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMqEKYGD
||| . ||| | . | || |. .. |.. ...|.||||| |..|||.||. . ..|. | | || |.|. . |.|
nryadvrcieetrvvlknhdrd....yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev.vkfgk
IVVTFDSA--LGRDGYQITSLYISH----SQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlaqdRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQ
.|. . | . .| . | | . | |||. |. | ...| |. . . | |..||||||.||| || .
yeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk....kvnpkekpicvhcsagvgrtatfvgidyatir
IQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
| .. ....| || || | |.. |. |.| |
imenpniemldivremramrfqavqshmqflflyvvlm
|
|||||||||
subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 84-315 | 4.7e-24 | 79.6 | In-house | 47-273 (312) | alignment | ||
Range on Protein: 84-315
Range on HMM: 47-273/312.0
NRYPSILPNSRTRVSLPQipDDplSSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFRMQ----E
|||| | | | .| |. || || .| . |..||||| |. ||.. . |.... . | || .| | ..
nrypniqcwdrgrftlag..de..nfyihanfvkict.kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr
KYGDIVVTFDsALGRDG----YQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlaqdrDDGKtgPVVVHCSAGIGRTGCFVATSIGI
| . . . |. ... . . . .| || ...|||||.||| |.|. |. | | ||. |||||.|||| .. |
vyteycteie.iggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk.....kdkk..pviahcsagvgrtgtlaliesmi
KQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
... | .. .. .| .| |.. || .. |..
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvl
|
|||||||||
subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 84-317 | 3.5e-14 | 47.1 | In-house | 51-278 (303) | alignment | ||
Range on Protein: 84-317
Range on HMM: 51-278/303.0
NRYPSILPNSRTRVSLPQipddplSSYINANVLKGYGEeiNAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDP-TFRMQEKYG
||. .. ..| | . |||| |. |. . . | || ||| | |||.|| . .... | .. . .| | |.
nrfvdvicldhskvklsd......ssyihasyleldss..kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeers
DIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDS--PRQLLQLVDeVHlAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQK
| | ||... | .| . |. . | ||| .| |. . |. . . . | .. | | .| ||.| | ...
irvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwq.lq.svlrkysdstptvymslsgcgragtfalfetahlslhs
E-NKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
| . .|..| . .| | |. ||. .|| | |
eqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
|
|||||||||
subfamily_egg_pd | Subfamily egg | 85-319 | 4.5e-28 | 92.8 | In-house | 45-271 (307) | alignment | ||
Range on Protein: 85-319
Range on HMM: 45-271/307.0
RYPSILPNSRTRVSLpQIPD-DPLSSYINANVLKGyGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERneTKCERYWPDPTFRMQEK-YG
| . . . .|| | ... | .| || .|| . .| || .| || ||.|||||.. ... |||.| || .|| ||| |
rskrvhckdssrvkl.elrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpG
DIVVT-FDSALGRD-GYQITSLYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVhlaqdrddgkTGPVVVHCSAGIGRTGCFVATSIGIKQIQK
. .. .. | ...| | . .. | .| . . || ..|... .. . ||||.. |. .....|| | . .. .
slrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrklrnl..........skpvvvqdilGvskaatlvaieiallsllr
E--NKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHHWR
| .|. | .|..| ||. .| |||| . .|
Gpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
|
|||||||||
0044763 | (Phosphotyrosine protein) phosphatases II | 92-317 | 4.3e-36 | 119.6 | In-house | 2-170 (178) | alignment | ||
Range on Protein: 92-317
Range on HMM: 2-170/178.0
NSRTRVSLPQIPDDPLSSYINANVLKGYgeeinAFIATQGPlsctvNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFrmqekygdivvtfdsa
||||.|. ... . | ||||. .. ......| |...... ... ||..|. .|.. || .|||. .
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................
lgrdgyqitslyishsqsprrlYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDgktGPVVVHCSAGIGRTGCFVATSIGIKQiqkenKVDILKIVC
..| .. .|||||||.....|..|. .. |.|... |||.||||||.||.|..|| . .|. .... ...
......................iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie
GMRMERGgMVETDSQYEFVYRALYHH
.|. | .|....|....|. ..
lvrerRp.ivpnpgqlrqLyefelrl
|
|||||||||
subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 95-311 | 1.1e-21 | 72.2 | In-house | 33-252 (290) | alignment | ||
Range on Protein: 95-311
Range on HMM: 33-252/290.0
TRVSLPQIPDDPLSSYINANVLKgYGEEInAFIATQGPLS-------CTVNDFWRMIWYHHCPIIVMITKLKERNET----KCERYWPDPTfRMQEKYGD
||| | . . || || .. . . . ..|.|| |. |...|| |. . .||. . .|... |..| |. . |...
trvvLkgygkrfnddyiHAnrvt.cpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesv.geelkfkg
IVVTFDSALGRDGYQITSLYISHSQ-SPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHlAqdrddgKTGPVVVHCSAGIGRTGCFVATSIGIKQIQ-KE
. | | |. .. | . . . . . |... | . |..... ||.|.. |. | .. ||.||| || | .. | .| | ..
ltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk.a......sktpvivHcvdGiSrsAalaaiilgyQkiaets
NKVDILKIVCGMRMERGGMVETDSQYEFVY
..| . ... .| .| .. .. .. ||
gsvkledvlkalrkqralaitsalelafvd
|
|||||||||
0046846 | (Phosphotyrosine protein) phosphatases II | 101-318 | 4e-46 | 152.3 | In-house | 5-173 (176) | alignment | ||
Range on Protein: 101-318
Range on HMM: 5-173/176.0
QIPDDPLSSYINANVLKGYgeeinAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfRMQ--Ekygdivvtfdsalgrdgyq
.. .|. ..|||||.. |. ..||||||| |. ||..|.. ... ..|..|...| . || .|||. ..
llgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi...................
itslyishsqsprrlyHYWYTAWPDHGVPDSpRQLLQLVDEVHLAQDRDdgktGPVVVHCSAGIGRTGCFVATSigikQIQKENKVDILKIVCGMRMERG
.|... ||||||||. ..||.|..... |.... |||.|||||||||||..|| ...|. ........ .|. |
................qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp
-GMVETDSQYEFVYRALYHHW
|.|.|..||.|.|.......
lgavqtpeQyrflyefellll
|
|||||||||
subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 103-157 | 1.2e-07 | 25.6 | In-house | 65-118 (347) | alignment | ||
Range on Protein: 103-157
Range on HMM: 65-118/347.0
PDDPLSSYINANVLKgYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITK
. |. .|||| .| . . . .| || || || |||.|. . .| | .
raddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
|
|||||||||
0043147 | (Phosphotyrosine protein) phosphatases II | 105-311 | 4.9e-43 | 142.2 | In-house | 2-154 (172) | alignment | ||
Range on Protein: 105-311
Range on HMM: 2-154/172.0
DPLSSYINANVLKGYGeEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLkernetkcerywpdptfrmqekygdivvtfdsalgrdgyqitslYI
|. | ||||. |..| .. ||||||||..|..|||||.. ... .||..|.| .
degsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel............................................ly
SHSQSPRRLYHYWYTAWPDHGVPdSPRQLLQLVDEVHLAQDRDDGktGPVVVHCSAGIGRTGCFVATSIGIkqiqkeNKVDILKIVCGMRMERGGMVETD
.. | ..|.|. ||||||| ....||.... .. .. ...| |||.||||||.||||..|| . . .......|. .|. |.|.|...
dpellerlgiqylylpwpDhgvp.llellleflefidellalspg..gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp
SQYEFVY
||| |.|
sqyrfly
|
|||||||||
0051429 | (Phosphotyrosine protein) phosphatases II | 106-319 | 4.1e-49 | 162.9 | In-house | 2-226 (272) | alignment | ||
Range on Protein: 106-319
Range on HMM: 2-226/272.0
PLSSYINANVLKGYGEE--INAFIATQGPLSCTVNDFWRMiWYHHCPIIVMITKLKERNETKCERYWP---------DPTFRMQEKYGDIVVTFDSALGR
|||.||||. ..||| . .......||| |..||||. . ... ||..... ||. ||.|||| .. .. ||...||. |
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell
DGYQITSLYIS---HSQSPRRLYHYWYTAWPDHGVP-DSPRQLLQLVDEvhlaqdrddgkTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVD-----
. | .. |... . . .|...|..||.||||||| .. ..||.|. . |||.||||||..|||..|| . . .. .| ||
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld...........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt
---ILKIVCGMRMERGGMVETDSQYEFVYRALYHHWR
....| .| | |.|.|. ||.|.|.|| . .|
nlyleeaveelraqrpgavqteeqylflyeallellr
|
|||||||||
0051082 | (Phosphotyrosine protein) phosphatases II | 106-315 | 2e-34 | 113.7 | In-house | 1-150 (151) | alignment | ||
Range on Protein: 106-315
Range on HMM: 1-150/151.0
PLSSYINANVLKGYgeeinaFIATQGPLSctvnDFWRMIWYHHCPIIVMITKLKERNetKCERYWPDPTfrmqekygdivvtfdsalgrdgyqitslyis
|||.|||.. . |. .....|||. ||..... ... ||......||. .| .|.|.
plsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...............................
hsqspRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLaqdrddGKTGPVVVHCSAGIGRTGCFVATSIGIKQiqkenkVDILKIVCGMRMERGGMVETDS
....|.... |||.|.|.|. ..|...... | |||.||||||.||||..|| . . . |.. ... .|. |.|.| .
.....ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnq
QYEFVYRALY
|. |...||.
qflfqlfall
|
|||||||||
0036282 | (Phosphotyrosine protein) phosphatases II | 108-311 | 2.9e-45 | 149.4 | In-house | 2-163 (174) | alignment | ||
Range on Protein: 108-311
Range on HMM: 2-163/174.0
SSYINANVLKGYgEEINAFIATQGPLSctvndFWRMIWYHHCPIIVMITKLKERNETKCERYWPDptfrmqekygdivvtfdsalgrdgyqitslyiSHS
|.||||. |... . . .||.||||. ||.|.. ... ..|| ...||.. .|| .|||. ..
sdyinaspldls.yitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre
QSPRRLYHYWYTAWPDHGVPDSPRqLLQLVDEVHLAQDRddGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQkENKVDILKIVCGMRMERGGMVETDSQY
| ..|.|. ||||||||.. ||..|..|. |. . .. |||.||||||.||||..|| . .... |. ||.|..| .|. |.|||.|.|||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy
EFVY
.|.|
rfly
|
|||||||||
subfamily_Sponge-PTP-4_pd | Subfamily Sponge-PTP-4 | 109-225 | 9e-09 | 29.7 | In-house | 14-125 (130) | alignment | ||
Range on Protein: 109-225
Range on HMM: 14-125/130.0
SYINANVLkGYGEEINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNEtkcerYWPDPTfRMQEKYGDIVVTFDSALGRDGYQITSLYISHS-
||||. . | . . .. || ||. | |||.|. . ..|.. ..| .| |||| .. ||.|| . . . . | |..
tyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdse.Plewyeediivtltdrdefknikasnleiesdl
-QSPRRLYHYWYTAWPDHG
.| . | . . || |
neshqaltmfqisnwpsdg
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 117-174 | 1.3e-11 | 38.5 | In-house | 230-283 (440) | alignment | ||
Range on Protein: 117-174
Range on HMM: 230-283/440.0
KGYGEeINAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLkerNETKCERYWPDPT
.|| ||||||| || || ||||.. .. |.|. .| |. | ||| |
egysk.knafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvnt
|
|||||||||
0049260 | (Phosphotyrosine protein) phosphatases II | 124-311 | 8e-41 | 134.6 | In-house | 9-143 (152) | alignment | ||
Range on Protein: 124-311
Range on HMM: 9-143/152.0
NAFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWpdptfrmqekygdivvtfdsalgrdgyqitslyishsqsprrlyHYWYTAWPD
..|||||||.. |..|||||.. ... .|||.|.| |... |||.|. .| .. |||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpD
HGVPDSPRQLLQLVDEVHLAqdrDDGKTGPVVVHCSAGIGRTGCFVATSIGIkqiqkeNKVDILKIVCGMRMERGGMVETDSQYEFVY
|||||.. ||.|.. .. . | |||.||||||.||||..|| . . ..|.....| .|. | |.|.. .|..|.|
hgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
|
|||||||||
subfamily_Nvec-PTP-3_pd | Subfamily Nvec-PTP-3 | 125-312 | 2.5e-29 | 96.8 | In-house | 5-197 (198) | alignment | ||
Range on Protein: 125-312
Range on HMM: 5-197/198.0
AFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDpTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH----SQSPRRLYHYWYTA
.|||| || |. |||.|.| |||. . .|. ||| | ||| . || . . | ||.| .. | | . || .|.
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpt.tesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts
WPDHGVPDSPRQLLQLVDEVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQI--QKENKVDILKIVCGMRMERGGMVETDSQYEFVYR
| .. |. . .| ... .. | ||.|||| | | || ||| ||.. | ||.... .| | |.. . .|.|.|.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
|
|||||||||
subfamily_Anemone-PTP-3_pd | Subfamily Anemone-PTP-3 | 125-312 | 2.8e-29 | 96.7 | In-house | 6-198 (199) | alignment | ||
Range on Protein: 125-312
Range on HMM: 6-198/199.0
AFIATQGPLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDpTFRMQEKYGDIVVTFDSALGRDGYQITSLYISH----SQSPRRLYHYWYTA
.|||| || |. |||.|.| |||. . .|. ||| | ||| . || . . | ||.| .. | | . || .|.
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpt.tesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts
WPDHGVPDSPRQLLQLVDEVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQI--QKENKVDILKIVCGMRMERGGMVETDSQYEFVYR
| .. |. . .| ... .. | ||.|||| | | || ||| ||.. | ||.... .| | |.. . .|.|.|.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
|
|||||||||
subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 129-316 | 2.3e-17 | 57.4 | In-house | 95-283 (302) | alignment | ||
Range on Protein: 129-316
Range on HMM: 95-283/302.0
TQGPLSCT---VNDFWRMIWYHHCPIIVMITKLKERNEtKCERYWPDPTfRMQEKYGDIVVTF---DSALGRD-GYQITSLYISHSQSPRRlYHYWYTAW
.| | . . |..||||.. ... .|.. . .| .. . ..| . ..||.. | ..| . | | | |.|. | | |
aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks.gdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvla.nvyvltnW
PDHGVPDSPRQLLQLVDEVhlaQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALYH
... ||.. .| . . .| ... . ..|. |.|| | |.. . ....||.... | || .| .| .|.. .|| ..|.||
kqkkvpvkyaeliktaakv...fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll
|
|||||||||
subfamily_Cele-PTP-7_pd | Subfamily Cele-PTP-7 | 132-309 | 7.7e-22 | 72.1 | In-house | 99-279 (302) | alignment | ||
Range on Protein: 132-309
Range on HMM: 99-279/302.0
PLSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTFR------MQEKYGDIVVTFDSALGRDGYQITSLYISHSQS----PRRLYHYWYTAW
| |.. .| .| .. |.| .....| .| || |. | | .. .. . .... .. | .. .. . ..||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw
PDHGVPDSPRQLLQLVDEVhlaqdrDDGKTgPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEF
|||| |. . . |... . |. |.||||||.|||| .|| ||. .|.. |.|.||. .| | | | ...| .
pdhGapkeaytaldilkfc......esykk.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
|
|||||||||
subfamily_hpo-7_pd | Subfamily hpo-7 | 133-309 | 1.5e-15 | 51.8 | In-house | 43-218 (263) | alignment | ||
Range on Protein: 133-309
Range on HMM: 43-218/263.0
LSCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEKYGDIVVTFDSALG---RDGYQITSlYISHSQSPRRLYHYWYTAWPDHGVPDS
| |.. |...| .||.. .| . ||..|.| . |. .. |. . ...| .... . . . || |. |... |
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlek.dekqklanvnvcttkvqsdvllktlells.tlgeKkkthtvkhysykgWiekndpel
PRQLLQLVDEVhlaqdRDDgKtgPVVVHCSAGIGRTGCFVATSIGIK----QIQKEN--KVDILKIVCGMRMERGGMVETDSQYEF
.|. |.... . |. | ..|||||.||||. |. . . . .... . ..| |... .| .| . ..| | |
areilnilkva.....rns.k..slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
|
|||||||||
subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 134-309 | 1.7e-19 | 64.9 | In-house | 38-212 (255) | alignment | ||
Range on Protein: 134-309
Range on HMM: 38-212/255.0
SCTVNDFWRMIWYHHCPIIVMITKLKERNETKCERYWPDPTfRMQEKYGDIVVTFDSALGR---DGYQITSlYISHSQSPRRLYHYWYTAWPDHGVPDSP
| ||. |...| .||.. ..| . ||..|.| . |. |. || . .||| .... . . . || |. |... |. .
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplek.deklkladvnvtttkssadvvlrtleits.tlgekkkthtvkhysykGWieknaPela
RQLLQLVDEVhlaQdrDDgKtgPVVVHCSAGIGRTGCFVATSIGIK----QIQKEN--KVDILKIVCGMRMERGGMVETDSQYEF
|..|... | . | | .||||||.||||. || . . . .... . ..| |... .| .| . ..| | |
reilnilkvv...r..ds.k..svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
|
|||||||||
subfamily_Cele-PTP-5_pd | Subfamily Cele-PTP-5 | 135-314 | 8.2e-07 | 21.9 | In-house | 129-305 (346) | alignment | ||
Range on Protein: 135-314
Range on HMM: 129-305/346.0
CTVNDFWRMIWYHHCPII-VMITKLKERNETKCERYWPDPTFRMQEKYGDIVVTFDSALGRDGYQITSLYISHSQSPRRLYHYwYTAWPDHgvpDSPRQL
|.||| ||. . .. .|. | .| | . .. | | . | | | |.| |. .. | . | .
sfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhh.hapwkhl...qqppkt
LQLVDEVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRAL
| .. .| . .. | | | ||. .|. . |.|.. . .|..|. .. .| | ||. .|| .| .
lpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaiv
|
|||||||||
subfamily_PTEN_pd | Subfamily PTEN | 194-311 | 4.4e-08 | 28.3 | In-house | 59-173 (184) | alignment | ||
Range on Protein: 194-311
Range on HMM: 59-173/184.0
RDGYQITSLYISHSQSPRRLYHY-WYTAWPDHGVPdSPRQLLQLVDEVHLAQDRDDGKTgpVVVHCSAGIGRTGCFVATSIgIKQIQKENKVDILKIVCG
.| |.| | .. . ... . . || | . | ..|.... ..|. . ||||| || |||| ... . .|. . |.. ..|..
kdhykiynlrserkydskkfdgrvavypfdDhnpp.plelleeivediekwleedkknv..vvvHCkaGkGRtGvlivayl.lkslllekaeealelfae
MRMERGGMVETDSQYEFVY
.|.. . | || .|.
aRtknkkgvtiPsqrRYve
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 197-317 | 6.5e-14 | 46.4 | In-house | 202-343 (350) | alignment | ||
Range on Protein: 197-317
Range on HMM: 202-343/350.0
YQITSLYISHSQsPRRLYHYWYTAWPDHGVPDSPRQLLQLVD-------EVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIG------IKQIQKE-N
...|.. .. |. | .|. . |.| .. |...|| .. . . |. .. |..||||||.|||| .|. .....|| .
nsltaitlaasd.PyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesr
KVD--------ILKIVCGMRMERGGMVETDSQYEFVYRALYHH
|.| | || .| | || . |. |.| || ..
kldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 199-315 | 1.9e-21 | 70.9 | In-house | 78-191 (440) | alignment | ||
Range on Protein: 199-315
Range on HMM: 78-191/440.0
ITSLYISHSQSpRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRddGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERG
| . ||. .| | | .| | .|||.||| .|.....| .|.. ||..|||||| |||| .| ... .. ...||. .. || .|
inasyingies.rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek..agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrp
GMVETDSQYEFVYRALY
||.| || ||. |.
qmvqtpeqyafvheavl
|
|||||||||
0048076 | (Phosphotyrosine protein) phosphatases II | 202-316 | 3.1e-27 | 90.4 | In-house | 36-141 (145) | alignment | ||
Range on Protein: 202-316
Range on HMM: 36-141/145.0
LYISHSQSPRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDdgktGPVVVHCSAGIGRTGCFVATSIGIKqiqkeNKVDILKIVCGMRMERGGMV
| . | ..|.|. ||||||||....||.... .. |.... |||.||||||.||||..|| . .. ..|.. ... .|. | |.|
ltselellerlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgav
ETDSQYEFVYRALYH
....|..|.|.....
pnpgqlrflyefele
|
|||||||||
0048179 | (Phosphotyrosine protein) phosphatases II | 205-312 | 4.1e-26 | 86.8 | In-house | 48-139 (144) | alignment | ||
Range on Protein: 205-312
Range on HMM: 48-139/144.0
ShsqsprrLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDrddgKTGPVVVHCSAGIGRTGCFVATSIGIkqiqkENKVDILKIVCGMRMERGGMVETD
..|... ||||||||.. .||.... .. |.. . |||.||||||.||||..|| . . ...... ... .|. | |.|...
e.......giqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnp
SQYEFVYR
.|..|...
gqlrfLle
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 206-315 | 2.2e-09 | 31.1 | In-house | 213-341 (349) | alignment | ||
Range on Protein: 206-315
Range on HMM: 213-341/349.0
HSQSPRRLYHYWYTAWPDHGVPDSPRQLLQ-------LVDEVHLAQDRDDGKTGPVVVHCSAGIGRTGCFVATSIGIK---QI-QKENKVD--------I
...| |. . |.| .. | .|| |.|. . . |. .. ...|||||| |||| .| . . .. ||.. |
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli
LKIVCGMRMERGGMVETDSQYEFVYRALY
|| .| | ||. .|. ..| ||
siivnelrkqrismvqnlaqfiaiyealL
|
|||||||||
0038934 | (Phosphotyrosine protein) phosphatases II | 210-313 | 4.6e-13 | 44.7 | In-house | 76-172 (194) | alignment | ||
Range on Protein: 210-313
Range on HMM: 76-172/194.0
PRRLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDGKtgPVVVHCSAGIGRTGCFVATSIgikqiQKENKVDILKIVCGMRMERGGMVETDSQYEF
... ..| .||.|.. | .||. .| |. ..| |. |.||| ||.||||..|| . . .. . . . .|. |.|.... ...|
ekagieylklpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdylea
VYRA
...
llkr
|
|||||||||
PTEN_1 | 212-271 | 4.9e-09 | 31.3 | In-house | 93-150 (196) | alignment | |||
Range on Protein: 212-271
Range on HMM: 93-150/196.0
RLYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDgkTGPVVVHCSAGIGRTGCFVAT
. . |. ..|||.|. . . ... . .. ... . |.||| ||.||.|. ||
sgveylhfpieDhgapslselfdicksfiewllsdpn..gnvVlVHCkaGlgRsGtvvaa
|
|||||||||
PTPc_DSPc_SM00012 | 213-314 | 1.4e-35 | 117.0 | In-house | 2-103 (105) | alignment | |||
Range on Protein: 213-314
Range on HMM: 2-103/105.0
LYHYWYTAWPDHGVPDSPRQLLQLVDEVHLAQDRDDGkTGPVVVHCSAGIGRTGCFVATSIGIKQIQKE-NKVDILKIVCGMRMERGGMVETDSQYEFVY
..||.||.|||||||... .|.|...|. . . ..|||||||||.||||.||| .| ..|..|| ..|||..||. .|..| |||.|. || |.|
vkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly
RAL
|||
ral
|
|||||||||
subfamily_PTPDC1_pd | Subfamily PTPDC1 | 213-310 | 1.6e-08 | 29.2 | In-house | 83-168 (182) | alignment | ||
Range on Protein: 213-310
Range on HMM: 83-168/182.0
LYHYWYtAWPDHGVPdSPRQLLQLVDEVHLAQDRddGKtgpVVVHCSAGIGRTGCFVATSIGIKqiqkeNKVDILKIVCGMRMERGGMVETDSQYEFV
.|.| . .|.|.||. | ...|..| |. | .. || | ||| || |||| .|. . . .... | . .| .| ..| .| |.|
iyvynf.gwkDygva.sleriLdivkvvafalqe..gk...vavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvelv
|
|||||||||
0048567 | (Phosphotyrosine protein) phosphatases II | 214-270 | 8.7e-07 | 23.4 | In-house | 28-96 (157) | alignment | ||
Range on Protein: 214-270
Range on HMM: 28-96/157.0
YH----------YWYTAWPDHGvPDSPRQLLQLVDEVHLAQDRDDGKTGPVVVHCSAGI---GRTGCFVA
|. .... . |.| | . .| ... .. . . . ....|||.|| |||.....
ynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLig
|
|||||||||
subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 216-314 | 1.5e-08 | 28.6 | In-house | 232-334 (347) | alignment | ||
Range on Protein: 216-314
Range on HMM: 232-334/347.0
YWYTAWPDHGVPDSPRQLLQLVDEVHLAQDR----DDGKTGPVVVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVY
| |.|| . || ...| || . .| |||| | |. |. | ||| |.|. . . | .. || .| |. | .
yncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyai
RAL
||
raa
|
|||||||||
subfamily_DSP23_pd | Subfamily DSP23 | 227-312 | 1e-07 | 26.7 | In-house | 64-140 (148) | alignment | ||
Range on Protein: 227-312
Range on HMM: 64-140/148.0
PDSPRQLLQLVDEVhlaqDRDDGKTGPVVVHCSAGIGRTGCFVATSIgikqiQKENKVDILKIVCGMRMERGGMVETDSQYEFVYR
| .. |. ..| | . . |. | ||| | |||| ..| . ||.|. . . .| | | ||| | . |.
ppaleqvvefvrvv....eeaeekneavsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrlrpgsvetveqeklvrd
|
|||||||||
DSPc | Dual specificity phosphatase, catalytic domain | 248-270 | 7.7e-06 | 20.8 | Pfam-A | 70-92 (133) | alignment | ||
Range on Protein: 248-270
Range on HMM: 70-92/133.0
DGKTGPVVVHCSAGIGRTGCFVA
. | . |.||| ||| |......
eqkgkkvlVHCqaGisRSatlii
|
|||||||||
DSPc | Dual specificity phosphatase, catalytic domain | 248-270 | 7.7e-06 | 20.8 | In-house | 70-92 (133) | alignment | ||
Range on Protein: 248-270
Range on HMM: 70-92/133.0
DGKTGPVVVHCSAGIGRTGCFVA
. | . |.||| ||| |......
eqkgkkvlVHCqaGisRSatlii
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 250-317 | 1.6e-19 | 64.7 | In-house | 246-314 (319) | alignment | ||
Range on Protein: 250-317
Range on HMM: 246-314/319.0
KTGPVVVHCSAGIGRTGCFVATSIGIKQIQKE-NKVDILKIVCGMRMERGGMVETDSQYEFVYRALYHH
. ||.||||| |.|||| .|. | |..... . ||| ..| .| .|. | | ||||.|. |. .
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
|
|||||||||
subfamily_CDC14_pd | Subfamily CDC14 | 250-318 | 3.4e-08 | 27.7 | In-house | 262-324 (328) | alignment | ||
Range on Protein: 250-318
Range on HMM: 262-324/328.0
KTGPVVVHCSAGIGRTGCFVATSIgikqiQKENKVDILKIVCGMRMERGGMVETdSQYEFVYRALYHHW
.| ..||| ||.||||...|. . |. .. .. .|. | |.| . | .|... . |
aeGaiavhCkaGLGrtGtLiacyl.....mkhyrftaaeaiawlricrPGsvig.pqqkfleekqaalw
|
|||||||||
subfamily_Sponge-PTP-7_pd | Subfamily Sponge-PTP-7 | 255-315 | 6e-13 | 43.0 | In-house | 2-62 (69) | alignment | ||
Range on Protein: 255-315
Range on HMM: 2-62/69.0
VVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|||||.| |||| |.| . . .|. | |||. | || | || . .| |.. ||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
|
|||||||||
subfamily_Sponge-PTP7_pd | Subfamily Sponge-PTP7 | 255-315 | 1e-12 | 42.2 | In-house | 1-61 (69) | alignment | ||
Range on Protein: 255-315
Range on HMM: 1-61/69.0
VVHCSAGIGRTGCFVATSIGIKQIQKENKVDILKIVCGMRMERGGMVETDSQYEFVYRALY
|||||.| |||| |.| . . .|. | |||. | || | || . .| |.. ||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
|