Gene NvecPTP-Un-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP081_AA protein Get Run
NvecP081_AA_7-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRA_pd Subfamily PTPRA 1-179 5e-47 155.4 In-house 10-186 (330) alignment 
Range on Protein: 1-179
Range on HMM: 10-186/330.0
KHEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGP
|. |.| | .   ..   ||   .|  ||. .   . . |   ..| ||. |||. |.. ||.|||.||  |  ..| |||| ..| |.  . .||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

LAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTenHGPLTITFVQEETFAYYSIRTFEIKPNKDGTH
...|. |||||||||.   |||.|.. |. ..||| |||..   |  .| ....  .|.    |..| | ..   |.|.
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt..yGnirvevedetvlvdytvrkflvqqlpdatr
subfamily_PTPRD_pd Subfamily PTPRD 2-360 1.7e-144 477.5 In-house 2-319 (564) alignment 
Range on Protein: 2-360
Range on HMM: 2-319/564.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKnKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPL
..|||......||..|.|..|.||..|.. ..|. .. || ...||.|..|||.||.||||||||||| .|.|..|.||||...|.|....|||||||||
skpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnRkTENHGPLTITFVQEETFAYYSIRTFEIKPNKdgthytqymhgtmfdssastnmllde
|.||.|||||.||||...|||.|.. |||..||..|||.| . ||..| ||.|...||..|.|.||||..| .|                          
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkk..........................

sldplddEVKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHL
       . . ..|.||||| |||||.|| .   ..||||.|..|.  |..||.||||||||||.|.|||||.|..||......||.......|.|||..
.......ssesreVrqFhFtsWPdhgvpesa..tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnam

VQEECQYIFIHDTLAEYIACnFVISLPIKALKDHVRMMRMPISIQppVKSKLDLEYEVL
||.|.||||||....|..|| .. ......||.|.....   . .    ..|.||.. |
VqteeQYiFiheailealac.gntevesenlkqhlqkLaeveedt..emtgleleFqrL
0051299 (Phosphotyrosine protein) phosphatases II 2-319 4.7e-95 313.6 In-house 2-286 (288) alignment 
Range on Protein: 2-319
Range on HMM: 2-286/288.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPL
. .|..| ....|..|.|.. .....||| . ...  ||.  ...|||. |||. ....||||||.|| .... .| ||||.|.|.||  ...|||||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGThytqymhgtmfdssastnmllde
 .|..|||||.||||.|||||.|...|.|| ||| |||.  ......|..|.|.. ||....| .||.|.....  .                       
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlld.......................

sldpldDEVKPMMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHL
       . .. .|..||.|.|||||.|.     ..||....   .  .| || ||||||||||.|.||..| .. ... .| .|........|.||...
......gdgesrtvthfhytnwpdhgvpd..spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgm

VQEECQYIFIHDTLAEYI
|| ..||.|....|.||.
vqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 2-322 2.7e-93 307.9 In-house 23-302 (308) alignment 
Range on Protein: 2-322
Range on HMM: 23-302/308.0
HEPIPYEAFRSHVKHlhADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLsltenDQSSHYINANYVDTY--NAMNAYIATQG
....... .  ....  |.. .....||| . ..   |..  ...|||. |||. ....||||||.|     |..|.||||.|||.|  .  ...|||||
slklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqg

PLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNR-KTENHGPLTITFVQEETFAYYSIRTFEIKPNKdgthytqymhgtmfdssastnml
|| .|. |||||.||||.|||||.|...|.|| ||| |||..   .....|..|.|.. ||....| .||.|.....                       
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg.......................

ldesldplddEVKPMMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTACVvpGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQR
          . .  .|..||.|.|||||.|.     ..||.. .   .   . || ||||||||||.|.||..| .. ... .| .|.|. ....| ||
..........dgesrtvthfhytnWpdhgvPps..peilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR

NHLVQEECQYIFIHDTLAEYIACN
.. || . ||.|....|.||. . 
pgmvqtpeqylflyralleylklk
0045450 (Phosphotyrosine protein) phosphatases II 2-320 1.5e-85 282.9 In-house 6-305 (307) alignment 
Range on Protein: 2-320
Range on HMM: 6-305/307.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNK--RLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTEND-QSSHYINANYV--------DTYNA
...|... . ..|. |..|. .... ||| . . ..    ..  ...|||. |||. ....|||.||.|| .... ..|.||||.||        |.|. 
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnRKTENHGPLTITFVQEETFAYYSIRTFEIKPN-KDGthytqymhgtmf
 ...||||||| .|. |||||.|||...||||.|. .|.|| |||.|||.. . . ..|..|.|.. ||. ..| .||.|.... ..|            
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtg............

dssastnmlldesldplddevKPMMVKQFHFTGWPDHGAPE-PGFEFPVLDLIMKSTACVvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGD---L
                     .. .|..||.|||||||.|. .   .  .....|  .   |. || .|||||||||.|.||... |.......|    .
.....................esrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldv

DIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
|... ....|.|| . || . ||.|... |.|.. 
dlleavkllreqRpgavqnpeqyrflyeallelll
0039614 (Phosphotyrosine protein) phosphatases II 2-321 2.9e-82 271.8 In-house 11-291 (297) alignment 
Range on Protein: 2-321
Range on HMM: 11-291/297.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRltWVQSQKPENQMKNRFANVVAYDHSRVVLSLTEN-DQSSHYINANYVDTYNA-MNAYIATQG
..|||....  ......|.. .....||| . . .    .. ...|||. |||. ....||||||.|.  .. | .| ||||.|||.|.   ...|||||
sipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLAKTISDFWRMIWEQNCRVIVMITNIIEKGRhKCAMYWPTKNRkteNHGPLTITFVQEETFAYYSIRTFEIkpnkdgthytqymhgtmfdssastnmll
|| .|. |||||.|||...||||.|. .|.|| ||| |||..     ..|..|.|....|. ..| .||.|.                            
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlev............................

dE------SldplddevkpmmVKQFHFTGWPDHGAPE-PGFEFPVLDLIMKSTACVvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLA
 .                   |..|..|||||||.|. .   . .|.|...  |   |. || .|||||||||.|.||... |. ... .|..|... ..
.tnngesrt............vthfqytgwpdhgvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavk

HIRNQRNHLVQEECQYIFIHDTLAEYIAC
..|.||.. || . ||.|..| |.|.. .
elreqRpgavqtpsqyrflydallellkr
subfamily_PTPRB_pd Subfamily PTPRB 2-188 5.8e-58 191.2 In-house 4-189 (293) alignment 
Range on Protein: 2-188
Range on HMM: 4-189/293.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPL
..||  | | .|||...|| |..|  |.| ... .|  . .......|. |||. |...|||||| |. ......| ||||||.. ||... .|||||||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTeNHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYMHGTM
 .|. |||||.||.....|||.|...|||. ||  |||.... . ..| ...|.|.||.   . ||...|. .|. .. .|| . . 
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsW
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-176 5.8e-47 155.1 In-house 3-173 (315) alignment 
Range on Protein: 2-176
Range on HMM: 3-173/315.0
HEPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRlTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPL
|.||| . . ..| . .|     |  ..| .   . .     ..| ||. |||. |..|||.||| | |.|||. |.|.|||..| ||  . |||.|||.
hqpipldqlityvaqkkastkngfkqdyesipggqlh.pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnrkTENHGPLTITFVQEETFAYYSIRTFEIKPNKD
. .. ||||...|...  |||.||..|. ..|.  ||| |      .|..|.| ..|| .  |..||. .  ...
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdn
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 3-340 3.5e-51 168.8 In-house 2-256 (392) alignment 
Range on Protein: 3-340
Range on HMM: 2-256/392.0
EPIPYEAFRSHVKHLHAdcDYKFFMEFEGVHEKNKRLTWVqSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLA
.|||   | . |.. .      || ||  . . .   . | .||. |. |||. |.. || .||.| . ..   | |.|| |...... .||||.||| |
qpipvaqfpafveknrh..salffeefhdlpgpdiypqtv.aqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpna

KTISDFWRMIWEQNCRVIVMITNIIEKGrhkcamywptknrktenhgpltitfvqeetfayysirtfeikpnkdgthytqymhgtmfdssastnmlldes
 ...|||||....|   |.|.|.. |                                                                          
aslddfwrmvfqenvttiamvtklkegd........................................................................

ldpLDDEVKpmMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLV
     |...   | ||||| |||.. |.  .   .| .| .  |     | ||..||||||||.|  | |||.. . .    .|.|||.. ||..| ..|
...kgddar..tvaqfhftewPdkdvpk..htssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymv

QEECQYIFIHDTLAEYIACNFVIsLPIKALKDHVRMMR
| . || ||. .. | .    .. .|.  . ||.. . 
qtkeqyafiygavledllwrntl.ipvvhftdhlqdls
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 3-176 3.5e-50 165.9 In-house 3-173 (319) alignment 
Range on Protein: 3-176
Range on HMM: 3-173/319.0
EPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRlTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLA
..|. . .....|.|..  . ..  ||. ..| ..  |. ...|.||. |||. |..|||..|||||  .. ..| ||||...|.|.  ...||||.||.
teievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

KTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNrkTENHGPLTITFVQEETFAYYSIRTFEIKPNKD
.||.|||||.||... ..||.|.. ||.. |.  |||..|   |. | |..|  .||  . | || ........
ntiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkss
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-182 1.5e-30 101.4 In-house 8-180 (297) alignment 
Range on Protein: 3-182
Range on HMM: 8-180/297.0
EPIPYEAFRSHVKH-LHADCdykFFMEFEGVHEKNkRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAmnAYIATQGPL
.|||   | . |..  |.|    |  ||  . | |   .  ...|  |  |.|..|.. || ||| |  ...| .| |.|| .| ...    .|.|| | 
rpiplsdfatlvqknrhtdv...fseeflclpean.iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPm

AKTISDFWRMIWEQNCRVIVMITNIIEKGRhKCAMYWPTKNRKTenHGPLTITFVQEETFAYYSIRTFEIKPNK-DGTHYTQ
  |. |||.|.....  .|||...  |. . ||| ||. |  .|   | ....    .    .. |..|.. .|   ..  .
katvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 3-99 1.8e-16 54.1 In-house 3-95 (95) alignment 
Range on Protein: 3-99
Range on HMM: 3-95/95.0
EPIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSqKPENQMKNRFANVVAYDHSRVVLSlTEndQSSHYINANYVDTYNAMNAYIATQG
 ||    | |||  .|.. | .|  ||  .         | |    |  |||| |.. || .||||. |   . | |||| .|| |   |.|||.||
kpihvsvfhshvlemhsnsdqefdnefksismtsgapytvgs.seanipknrflnifpydatrvvlt.tk..rdsdyinacfvdgyarkncyiaaqg
0043336 (Phosphotyrosine protein) phosphatases II 4-319 6.4e-87 286.8 In-house 1-277 (278) alignment 
Range on Protein: 4-319
Range on HMM: 1-277/278.0
PIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKrLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAK
||... .  ....|.... ...  ||| ... ..  |.  ...|||. |||. ....||||||.|||...| .| ||||.|||.||  ...||||||| .
pisvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

TISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPtknRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGthytqymhgtmfdssastnmlldesl
|. |||||.||.....|||.|.  |.|| ||| |||   ......|..|.|.. ||....| .||.|.....||                          
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdg..........................

dplddevKPMMVKQFHFTGWPDHGAP-EPGFEFPVLDLIMKSTAcvvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLV
       .. .| ..|..||||||.|  .   .  |  ...  .   .  ||..|||||||||.|.||... .. .....| .|... ....|.|| . |
.......esrtvthyhylgwpdhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgav

QEECQYIFIHDTLAEYI
| . ||.|... |.||.
qtpsqyrflyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 4-183 2.3e-43 143.5 In-house 3-183 (305) alignment 
Range on Protein: 4-183
Range on HMM: 3-183/305.0
PIPYEAFRSHVKHLHADCDYKFFMEFEGVHEKnKRLTWVQsQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAK
.|  . . ...|. ... | .. .... . |. .  . |. .| .|. |||..... .|..|. |. .|... |.||||.|||.|.  ..||..|||| .
iialddlaayikearvysdkgleaqykslyee.eesidvg.kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn

TISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKP---NKDGTHYTQY
|..||||.|.|   ..|||.|...| |..|| .|||.. ......|.....  .|.|.. | .| ..|     .|..   .||
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqy
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 4-185 8.3e-34 111.8 In-house 2-180 (315) alignment 
Range on Protein: 4-185
Range on HMM: 2-180/315.0
PIPYEAFRSHVKHLHADcdYKFFMEFEGVHEKNKRLTWVqSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAK
|||   | . |.. .      |  ||  . . .   . | .....|. |||. |.. .|..||.| . ...  | |||| |. ...  .||||.||||  
pipvaqfpafvnknrht..alfseefhdlpdPdiyrqrv.aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka

TISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYMH
...|||||.....   |||.|.  |  . ||. ||| .. .. . | . .. .. |. .   .| . ..  ..    ||.  
svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqf
subfamily_PTPRG_pd Subfamily PTPRG 5-321 2.8e-98 324.6 In-house 1-289 (563) alignment 
Range on Protein: 5-321
Range on HMM: 1-289/563.0
IPYEAFRSHVKHLHADCDYKFFMEFEGVHE--KNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTEN-DQSSHYINANYVDTYNAMNAYIATQGPL
.| . | .|| .|||| | .|  ||| ...  ..| |.  .||||||. |||  |.||||.||| || . . ...  ||||||.| |.  .|.|||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknRKTENHGPLTITFVQEETFAYYSIRtfeikpnkdgthytqymhgtmfdssasTNMLLDE
..|. ||||||||||  .||||||. |.||.|| .|||.   ..|. | |..| ..||..|.|..|                           | .. . 
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvr...........................tlviknl

SLDPLDDEVKPMMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHL
 |.  ..  .  .|.|.|.| |||||.||  .. |||  . || |     .||.||||||||||.| .||.|...|.|...   ..|.|| ||| |||.|
klkkkkqcdteklvrqyhytkWPdhgvPe..hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnfl

VQEECQYIFIHDTLAEYIAC
||.| ||||.||.| | || 
vqteEqYiflhdalleaias
subfamily_Ptp69D_pd Subfamily Ptp69D 5-322 2.7e-82 271.3 In-house 4-289 (307) alignment 
Range on Protein: 5-322
Range on HMM: 4-289/307.0
IPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKT
|. .  .. .|  . | |. .  |.| .....  .. . |.| ||..|||. ...|.|. ||.|. .. ...| ||||... .|.  . .|| |.|.  |
iaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveat

ISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnrKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTqymhgtmfdssastnmlldesld
| ||||||.||.  .|||..|. || |.||| |||    .. ..| . ...|.||.  .| ||....  .|. .                          
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgev.......................

plddeVKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQE
      .   | |.|.|||.|  .||      .|.|| .         .|.|||||||||||| |. .||...... .  .|||..  ..|.||| ||| 
.....edsrkvvqyhytgWkDskvPeva..rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

ECQYIFIHDTLAEYIACN
  ||.|..  |..|.   
leqYvflyralldyssyg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 5-176 4.1e-62 205.1 In-house 2-171 (318) alignment 
Range on Protein: 5-176
Range on HMM: 2-171/318.0
IPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKT
|. |...|||..|... . ... |.| .. ...  |...| .| |..|||.||..||||.|| |. .|....| ||||||.| |.. .||||.|.||..|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

ISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnrKTENHGPLTITFVQEETFAYYSIRTFEIKPNKD
|.|||||.||||..||||.|.. |.|..|.. ||| |  .....| |...  .| ....| .|.|... .. 
ieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrtee
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 5-184 6.4e-44 145.0 In-house 2-180 (290) alignment 
Range on Protein: 5-184
Range on HMM: 2-180/290.0
IPYEAFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLS-LTEN-DQSSHYINANYVDTYNAMNAYIATQGPLA
|| . |  .| . ||  . .|  .|. ..  ..  |      ..|. .|||||.| ||  |..|  .... | . .|||| |.. |.  ..|||||||. 
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

KTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKnrKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGtHYTQYM
.|. |||..||.... .|||.|||||.|..||  |||..  .|.. |. .|. ..|||. .| .|..|.| .. . ...| .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllneetlneyierklevknknsa.gakqsv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 5-183 1e-37 124.7 In-house 2-178 (287) alignment 
Range on Protein: 5-183
Range on HMM: 2-178/287.0
IPYEAFRSHVKHLHADCDYKF---FMEFEGVHEKNKRLTWVQSqkPENQMKNRFANVVAYDHSRVVLSltenDQSSHYINANYVDTYNAMNAYIATQGPL
|| | |   |.. ||  .  |   |. .| | .... .|   .  ..|. |||..... .|  ||.|     ..   |||| ..|.|.  .|.|....|.
ipvekfgefvakghakgnegfknqftvleqvtqredevthnia..sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPm

AKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRktENHGPLTITFVQEETFAYYSIRTFEIKPNKD-G--THYTQY
..|. .||..|...|  .|||...  |. ...|  |||...      |. .|....||. | | .|..|.| ..  |   . .||
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqy
0040438 (Phosphotyrosine protein) phosphatases II 8-337 1.3e-89 295.9 In-house 3-293 (317) alignment 
Range on Protein: 8-337
Range on HMM: 3-293/317.0
EAFRSHVKHLHADCDYKFFMEFEGVHEKNKRlTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISD
. .  ... |..   ...  ||| . . ..  |.  ...|||. |||. ... ||||||.|| ...| .| ||||.|||..|  ...||||||| .|. |
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldpld
||||.|||...||||.|.  |.|| ||| |||.  ..| ..|..|.|...||. |.. .||.|.....|                               
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgd...............................

deVKPMMVKQFHFTGWPDHGAP-EPGFEFPVLDLIMKSTAcvvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEEC
   .. .|..||.|||||||.|  |   .  |... .. .   .. ||..|||||||||.|.||... |. ... .|..|... ....|.||.. || . 
..sesrtvthfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpe

QYIFIHDTLAEYIACNFViSLPIKALKDHVR
||.|..| |.||. .. . . |.. || .. 
qyrflydalleylkrklt.lepaselklkll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 9-179 1.2e-29 98.0 In-house 6-171 (439) alignment 
Range on Protein: 9-179
Range on HMM: 6-171/439.0
AFRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQS--QKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTIS
 |. ||..|. . .  |  .|| .   .   . . |   .  .| |||. .|.|.||.||.|  .     ||||||||.. |   . |||||||  .|  
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd

DFWRMIWEQNCRVIVMITNIIEKGRhkcamYWPTKNRKteNHGPLTITFVQEETFAYYSIRTFEIKPNKDGTH
||||...|...  |||.||..|  .     |||...     .| ...   ..  .  | || | .  ..| |.
dfwrlviekktvtivmltnlvesyk.....ywpsdaev..cygdiavrvdrnielpnyvirgfkvfnerdtte
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 10-174 1.1e-47 157.5 In-house 2-165 (281) alignment 
Range on Protein: 10-174
Range on HMM: 2-165/281.0
FRSHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFW
.| |.|.|... .  | .|.|.... . . | . |...||..|||. |.||||..||... .|..... |||||.|..|.  ..|||||||. ... .||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRkTENHGPLTITFVQEETFAYYSIRTFEIKPN
.|.|||. ..|||.|. ||.|. ||  ||| .|  . . | .|.....||. | |  |.|... .
qmvweqkvsaivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfklere
subfamily_PTPRK_pd Subfamily PTPRK 12-333 1.5e-80 265.4 In-house 11-290 (314) alignment 
Range on Protein: 12-333
Range on HMM: 11-290/314.0
SHVKHLHADCDYKFFMEFEGVHEKnkrltWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRM
 ... |..   | |  |.| . |      |  ..| ||..|||. ...|||.|||.|  ...|.|| ||||...|.|.  .|.|.||||| .|. ||||.
qsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl

IWEQNCRVIVMITNIIEKGRHKCAMYWPTKnrkTENHGPLTITFVQEETFAYYSIRTFEIKPnkdgthytqymhgtmfdssastnmlldesLDPLDDEVk
....||  |||.|...|.|| ||  ||| .   || .|.. ...|. |. | . .|.| ..                              |    .|. 
vydencasivmltelvevgrvkClkyWPed...tevygdikvelvetellaelvvrifrvek.............................largqeei.

pMMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFI
  .|.||.|.|||||. |    .  .|.|. .  .   .. |..||||||| ||.|.||.||...  |. .| .|.||    .|...  .|. | ||.||
.revrqfqflgWpdhdvPv..satgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfi

HDTLAEYIACNFvISLPIKALK
.| . |   |    ..|.  .|
ydvileaclcge.taipvsefk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 12-191 8.5e-47 154.6 In-house 10-188 (288) alignment 
Range on Protein: 12-191
Range on HMM: 10-188/288.0
SHVKHLHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRM
..|.. .|.    |  |.. . . .|  .  ......|. |||. |...||. || |   |. ... ||||.|.| .. ...|||||||||.|. |||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWEQNCRVIVMITNIIEKGRHKCAMYWPTKNrKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYMHGTMFDS
..|..   |||.|...|.|..||  |||... | .|.| .|.| |....   .  |..... .|.  . ||| . .  | 
vyenktstivmltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdh
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 13-183 8.1e-44 145.0 In-house 13-182 (325) alignment 
Range on Protein: 13-183
Range on HMM: 13-182/325.0
HVKHLHADCDYKFFMEFEGVHEKnKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMI
||.. .|. .  |  ||. .  .    .   . ||||. |||| ||||.|.|||||   ..| || ||||.|. ..   . ..|.| ||..|| |.||..
hvekkkaqdqdgfahefgllpsd.dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlv

WEQNCRVIVMiTNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDG-THYTQY
 . .| |.|. .|....| ..||.||| .  |. . |.| . ..  |... |  | ...|  |.| |   . 
ldWrcsvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkq
0036941 (Phosphotyrosine protein) phosphatases II 17-330 1.1e-88 292.7 In-house 7-288 (297) alignment 
Range on Protein: 17-330
Range on HMM: 7-288/297.0
LHADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLslteNDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQN
 .... ...  ||| . .  .  ..  ...|||. |||. ....|||.||.|    .|..| ||||.|||.|.  ...||||||| .|. |||||.||||
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

CRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEET--FAYYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddeVKPMM
..||||.|. .|.|| ||| |||...... ..|..|.|.. .|.  ...| .||.|......                                  .. .
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgn.................................gesrt

VKQFHFTGWPDHGAPE-PGFEFPVLDLIMKSTaCVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIH---DNGDLDIFNFLAHIRNQRNHLVQEECQYIF
|..||.|||||||.|| |   .  ..|. |      |. || .|||||||||||.||..| |. ...    .| .||.... ..|.||.. || . ||.|
vthfhytgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrf

IHDTLAEYIACNFVISLPIK
....|.|.. .. ..  ..|
lyeallellkkkltkepllk
0047943 (Phosphotyrosine protein) phosphatases II 18-319 5.4e-87 287.0 In-house 7-272 (273) alignment 
Range on Protein: 18-319
Range on HMM: 7-272/273.0
HADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLslteNDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNC
.... .....||| . .  . ||.  ...|||. |||. ....||||||.|    .|..|.||||.|||.||  ...||||||| .|. |||||.||||.
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

RVIVMITNIIEKGRHKCAMYWPTKNRK-TENHGPLTITFVQEETFAYYSIRTFEIKPNKdgthytqymhgtmfdssastnmlldesldplDDEvkPMMVK
|||||.|...|.|| ||| |||... . ....|..|.|.. |||...| .||.|.....                               ..|  . .|.
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg...............................tge..srtvt

QFHFTGWPDHGAPEPGFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLA
.||.|||||||.|.   ..  .  .....   .|. || ||||||||||.|.||..| .. ... .| .|... ....|.|| . || ..||.|....|.
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

EYI
||.
eyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 18-182 1e-40 135.0 In-house 29-189 (319) alignment 
Range on Protein: 18-182
Range on HMM: 29-189/319.0
HADCDYKFFMEFEGVHEKNKRLTW-VQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQN
  |   |. .||  . ..   |.    .  ..|. |||. |..|.|...| |  ..  . | |||| .|. |   . |||.||||  |. ||||||||.|
fdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyn

CRVIVMITniiekgRHKCAMYWPTKNRKTENHGPLTITFVQEETFayYSIRTFEIKP---NKDGTHYTQ
|  ||..|      ..||. ||| |  ..|... . .. |.|     | .| .|.     .||  . ||
cstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitq
subfamily_ptpA1_pd Subfamily ptpA1 18-172 1.1e-30 101.7 In-house 16-165 (418) alignment 
Range on Protein: 18-172
Range on HMM: 16-165/418.0
HADCDYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAmNAYIATQGPLAKTISDFWRMIWEQNC
|  | .|   ||  . |        . .|  |  |||..|..  .|.|| |   .. . | ||||||.|     . .|.||||| .||.|||||.||. |
hikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrc

RVIVMITNIIEKGRHKCAMYWPTKNRkTENhgpLTITFVQEETFAYYSIRTFEIK
|.|||..   |. | ||  ||| .    |.   ..|    .| |  ||.   |. 
riivmlsresencrikcdrywpeqig.geq...fsiygngnevfgtysvelvevi
0045098 (Phosphotyrosine protein) phosphatases II 22-321 1e-76 253.2 In-house 6-274 (278) alignment 
Range on Protein: 22-321
Range on HMM: 6-274/278.0
DYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVlsltendqssHYINANYVDTYNamNAYIATQGPLAKTISDFWRMIWEQNCRVIV
......||| ..  .   ..  .....|. |||. ....||||||.           ||||.|.|.|.  ...||||||| .|..|||||.||....|||
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgyp..kkfIatqgPlpstvadfwrmlwelgitviv

MITNIIEKGRHKCAMYWPTknRKTENHGPLTITFVQEETFAYYSIRTFEIKPN----KDgthytqymhgtmfdssastnmlldesldplddeVKPMMVKQ
|.|. .|.|| |||.|||   ......|..|.|...||.. .| .||...       .|                                  ... |..
mltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltvered.................................lesrgvth

FHFTGWPDHGAPEPGFEFPVLDLIMKSTACVV-------------PGTGPLVVHCSAGVGRSGAFIVIDSMIKRIhdNGDLDIFNFLAHIRNQRNH-LVQ
.|...|||||.|.  .  ..|.|.    ...              .. || .|||||||||.|...... |....  .| .|... ....|.||..  ||
lhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavq

EECQYIFIHDTLAEYIAC
 . ||.|... |.|.. .
nleqyrflyefllelllr
subfamily_PTPN14_pd Subfamily PTPN14 22-158 2.9e-35 116.7 In-house 22-161 (300) alignment 
Range on Protein: 22-158
Range on HMM: 22-161/300.0
DYKFFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDqSSHYINANYVDTYN--AMNAYIATQGPLAKTISDFWRMIWEQNCRV
. | |.|.| . .|..  .   .. |||. |||| .|. |...|| || |... |. ||||  . .    .   ||..|||| .|. |||.|.|||. ..
egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IVMITNIIEKGRHKCAMYWPTK--NRKTENHGPLTITFVQE
|||.|...|.|..|.  |.| .  ..|| ..|   .|    
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfs
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 22-182 2.4e-28 93.9 In-house 5-159 (267) alignment 
Range on Protein: 22-182
Range on HMM: 5-159/267.0
DYKFFMEFEGVHEKNK-RLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDqsshYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVI
. ..  ||| ...  . . |  ||   .|| .||. ... ||..||.|. .|..    |||| ||..|.  ||.|.||.|| .||.||. .| .|.. ||
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMITNIiekGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQ
|..|..   .  .  ..|| |  .....  ||. .  |.    | | |.|.| ... .|   
vlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 23-322 8.3e-58 190.4 In-house 15-296 (301) alignment 
Range on Protein: 23-322
Range on HMM: 15-296/301.0
YKFFMEFEGVHEKNKRLTWVQSQKpENQMKNRFANVVAYDHSRVVLSLTEN--DQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVI
 ||  ... ..|.... . |. .. ||.. ||| |.. ||. |..|. ..|   .. .||||.|.| |.  ...||.|||. ||. ||||.||..    |
nkfeeqykelkegedksctvglse.enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPnKDGTHytqymhgtmfdssastNMLLDESLDPLDDEvKPMMVKQFHF
||.||  |. ..||  |||. . ..|. ||.|.|.|.| ..  . || . .|  .||.                 |  .  ...   |  ... | |.. 
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvki.qdgsn................ngyierkfkvksdk.sswdvlqlqv

TGWPDHGA-PEPGFEFPVLDLIMKSTAcvVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYI
| ||..|  .||     |.| ... .    .| ||.|||||..|.||| .. ..  .     .|  |.|.    .| ..   |.   ||..|.| . .|.
tdWpqdGvvreprtvLqviddvihrqq..kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

ACN
..|
qln
subfamily_PTPN6_pd Subfamily PTPN6 24-320 8.1e-79 259.8 In-house 27-298 (306) alignment 
Range on Protein: 24-320
Range on HMM: 27-298/306.0
KFFMEFEGVHE--KNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSlTENDQSSHYINANYVD--TYNAMNAYIATQGPLAKTISDFWRMIWEQNCRV
 |  ||| . .  ..|.|.  ...||||. |||. |.. .||.||.|.  .. . | ||||||..  . .  ..|||||| | .|.||||||.|..|.||
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMITNIIEKGRHKCAMYWPTKNRKTEnHGPLTITFVQEETFAYYSIRTFEIKPNkdgthytqymhgtmfdssastnmlldesldplDDEVKPMMVKQFH
|||.|. .|.|..||| |||....|.| .| ...| |.|.. |.| .|.. .. .                                ... .   | |.|
ivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk................................kkkkeerevfqyh

FTGWPDHGAPEPGFE-FPVLDLIMKSTACVV-PGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNG---DLDIFNFLAHIRNQRNHLVQEECQYIFIHDT
|. ||||| |.        |. . . .  .    .||.|||||||.|| |.||||| ..| |. .|   |.|| ..   .|.||. ||| | || |.. .
fksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvyka

LAEYIA
...|| 
ikkyie
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 24-149 1.8e-23 78.0 In-house 17-139 (307) alignment 
Range on Protein: 24-149
Range on HMM: 17-139/307.0
KFFMEFEGVHEKNKRLTWVQSQKpENQMKNRFANVVAYDHSRVVLSLteNDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMI
..  ||. . .|.     |.. .  |. |||. .| . |..|.|. .  .  .| || |||. .    . .|..|||| .|. .|| |. ...   ..|.
alvdefrvlakktpegvtveafs.antdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TNIIEKGRHKCAMYWPTKNRKTENHG
 ..|| .. ||  ||| .. ..  .|
ckvielakikceqywpleegqklvfg
0046845 (Phosphotyrosine protein) phosphatases II 25-323 9.5e-88 289.5 In-house 2-278 (284) alignment 
Range on Protein: 25-323
Range on HMM: 2-278/284.0
FFMEFEGVHEKNKRL--TWVQSQKPENQMKNRFANVVAYDHSRVVLSLTEND-QSSHYINANYVDTY-----NAMNAYIATQGPLAKTISDFWRMIWEQN
.. ||| .   .  |  ..  ...|||. |||. ....||||||.|. ...| ..|.||||.|||.|     .  ...||||||| .|. |||||.||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CRVIVMITNIIEKGRHKCAMYWPTKnRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddEVKPMMVK
.|||||.|...|.|| ||| |||..  .. ..|..|.|.. ||.. .| .||.|.....                                 . ....|.
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgy................................tgesrtvt

QFHFTGWPDHGAPEP-GFEFPVLDLIMKSTACvVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNG---DLDIFNFLAHIRNQRNHLVQEECQYIFIH
.||.|.|||||.|.     .  |.|. ..    .|| || ||||||||||.|.||..| ...... .|    .|... ....|.||.. || . ||.|..
hfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvy

DTLAEYIACNF
..|.||. . .
ealleylklkl
DSPc_SM00195 25-319 6.1e-85 280.1 In-house 2-262 (263) alignment 
Range on Protein: 25-319
Range on HMM: 2-262/263.0
FFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMIT
. .||| . |...  .  ...|..|. |||. |.. |||.|| |. .|....| ||||||....|  ..|||||||| .|..|||||.||.....|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFA-YYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddeVKPMMVKQFHFTGW
.  |.|. ||. ||| .. ..|..| .....|..|.    . .||.|.. ...                                  ..  |.|.....|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.................................eetrkvtqyqyknW

PDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYI
||||.|.   . .||.|. . . .    .||.||||||||||.|.|..||......... ..|||. . ..|.|| ..||.. ||.||.....|||
pdhgvpds..tksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 25-319 6.1e-85 280.1 In-house 2-262 (263) alignment 
Range on Protein: 25-319
Range on HMM: 2-262/263.0
FFMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMIT
. .||| . |...  .  ...|..|. |||. |.. |||.|| |. .|....| ||||||....|  ..|||||||| .|..|||||.||.....|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFA-YYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddeVKPMMVKQFHFTGW
.  |.|. ||. ||| .. ..|..| .....|..|.    . .||.|.. ...                                  ..  |.|.....|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.................................eetrkvtqyqyknW

PDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYI
||||.|.   . .||.|. . . .    .||.||||||||||.|.|..||......... ..|||. . ..|.|| ..||.. ||.||.....|||
pdhgvpds..tksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN9_pd Subfamily PTPN9 26-178 4e-50 165.5 In-house 19-171 (297) alignment 
Range on Protein: 26-178
Range on HMM: 19-171/297.0
FMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITN
  |.. .....   |  .|... |  |||...|. ||..||||. ...|. | |||||.|| |.  .|.||||||| ||.||||||.|||...||||.| 
skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttr

IIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGT
..|.|| ||. |||... .....| |... |. |.   | .|..|||  |.. 
vvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 26-185 7.2e-48 158.3 In-house 33-191 (298) alignment 
Range on Protein: 26-185
Range on HMM: 33-191/298.0
FMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITN
| ... | .. .. ..  ..||||. |||.|...|.|.|||||. ...|. | |||| ....|.  ||.||||.|| .|..|||||..|..  .|||.||
fqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltn

IIEKGRHKCAMYWPTKnrKTENHGPLTITFVQEETFAYYSIRTFEIKPNK-DGTHYTQYMH
. |... |.  |||..  ..|..| .|..  ..|.|| . .|..... .| ....  . .|
leeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlh
subfamily_PTPN3_pd Subfamily PTPN3 26-176 4.2e-42 139.0 In-house 18-167 (280) alignment 
Range on Protein: 26-176
Range on HMM: 18-167/280.0
FMEFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENdqssHYINANYVD----TYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIV
...|| .. |.. |.  ...||||  |||. ....||. || |. .|.     |||||||.    . ...| ||||||||||| .|||.|.|||....||
laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MITNIIEKGRHKCAMYWPTkNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKD
|.|...|.|| ||  |||. . .. ..| ....  .|..   | .| . .| .. 
mlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdket
subfamily_PTPN13_pd Subfamily PTPN13 28-177 7.7e-34 112.2 In-house 16-163 (273) alignment 
Range on Protein: 28-177
Range on HMM: 16-163/273.0
EFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSltenDQSShYINANYVDTYNA--MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITN
||. ..|    .|  ...| ||. |||. ||. ||..|| |.    |... ||||...          |||.|||| .|..|||.|.|||...||.|.|.
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

IIEKGRHKCAMYWPTKNRKT-ENHGPLTITFVQEETFAYYSIRTFEIKPNKDG
  |||. ||  ||| ...|.   .. |... .. .    ...|....| .. |
ekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 28-88 4e-07 23.9 In-house 18-77 (244) alignment 
Range on Protein: 28-88
Range on HMM: 18-77/244.0
EFEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENdQSSHYINANYVDTY
|| |. .. . .  ...    |  |||. |.. .|..||.|| ... ..| ||||||..  
efvglsdhtreflqtnavlsanatknryinilpfdetrvilssskk.egsdyinanyiqgs
subfamily_PTPN1_pd Subfamily PTPN1 29-312 1.4e-64 212.6 In-house 12-264 (290) alignment 
Range on Protein: 29-312
Range on HMM: 12-264/290.0
FEGVHEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENdqssHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIE
.. .... . ..  ....|||. .||. .|  |||||..|  ..|    .||||. |.  .|   || |||||..|.. ||.|.|||... .||. ...|
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

KGRHKCAMYWPTKNRKTE---NHGPLTITFVQEETFAYYSIRTFEIKPnkdgthytqymhgtmfdssastnmlldesldplDDEVKPMMVKQFHFTGWPD
|.. ||| |||..... |   ..  |......||.  || .|..|..                                      .   . .||.| |||
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen.................................lktqetreilhfhyttwpd

HGAPEPGFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGD---LDIFNFLAHIRNQRNHLVQEECQYIFIH
 | ||    |  .   .... ....  || |.|||||.||||.|...|... .|....|   .|| . | ..|..|  |.|   |  | .
fgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 29-171 8.2e-36 118.3 In-house 16-159 (287) alignment 
Range on Protein: 29-171
Range on HMM: 16-159/287.0
FEGVHEKN--KRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTeNDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNI
.. . |      .|. ....  .  |||.|.|. .|..||.|| .  .. | ||||||| .|.  .|.||.|||.| |. ||||...|..  .....|  
vdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtre

IEKGRHKCAMYWPTKnRKTENHGPLTITFVQEET-FAYYSIRTFEI
.|..| ||  ||| . ..    |  ... .. .     |..|.. .
veearlkcykywPer.evPmrvGGysvvlldydikePeygvralrl
subfamily_PTPN23_pd Subfamily PTPN23 30-176 4.4e-34 112.6 In-house 25-167 (288) alignment 
Range on Protein: 30-176
Range on HMM: 25-167/288.0
EGVHEKNKRLTWVQSQKpENQMKNRFANVVAYDHSRVVLSltenDQSSHYINANYVDTYNAMN-AYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIE
|  ..|. | . .   |  .  |||. ... |||.||.|     ..   |||| .|    ..   .||||.||..|..|||.|..||  .||||...  |
eqkqdkearkrsiaiak.lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskee

KGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKD
.|..|.. |||... .|...|.|..|  ....  ... |..... .. 
lgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda
subfamily_egg_pd Subfamily egg 33-155 4.5e-23 76.4 In-house 24-146 (307) alignment 
Range on Protein: 33-155
Range on HMM: 24-146/307.0
HEKNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKgrH
.|  .. .  .. . .|. | |   |   | ||| | | .   .  .| ||.|.    .| .| .| ||  |  |||||....... |||.|   |   .
eesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..e

KCAMYWPTKNRKTENH--GPLTITF
.|  |||  . ..     | | |. 
rceyywpkaesdslvtvpGslrien
subfamily_PTPRN_pd Subfamily PTPRN 35-175 1.8e-31 103.9 In-house 42-182 (297) alignment 
Range on Protein: 35-175
Range on HMM: 42-182/297.0
KNKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYV-DTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHK
...  |   .....|  ||| ..|..|||||| |. . ....|.||||  . |.   . ||||||||||.|..|||.|.||| . |||..|.. |.| ..
eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkq

CAMYWPTKNrkTENHGPLTITFVQEETFA-YYSIRTFEIKPNK
|. ||| .   .| ..   . .| |  ..  | .|.| .|  .
ckrywpdeG..sevyhiyevhlvsehiwcddylvrsfylknlq
subfamily_PTPN12_pd Subfamily PTPN12 36-185 2.8e-44 146.1 In-house 27-177 (290) alignment 
Range on Protein: 36-185
Range on HMM: 27-177/290.0
NKRLTWVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCA
.|  .  ...|.||. |||. ... ||.|||.|| .|... | |||||..   .   .|||.||||.||..||||||||.| ...||. ...| |..||.
ekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

MYWPTKNRKTENHGPLTITFVQEETFA-YYSIRTFEIKPNKDGTHYTQYMH
 ||| .. .. ..|....|  .|...   . |||.... .|.  . .|. .
rYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhY
subfamily_eak_pd Subfamily eak 36-179 1.3e-14 48.4 In-house 39-179 (332) alignment 
Range on Protein: 36-179
Range on HMM: 39-179/332.0
NKRLTWVQSQKPENQMKNrFANVVAYDHSRVVLSLTENDQsSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCA
.. |.  .... |.  .|   ..| ||.  | |. .  ..   ||||  ..  .  . || |  .  . .  ||.|. ||.   ||.. . .|..  |  
qrllsisetarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksd

MYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKDgTH
 |.| | |.  ..| | ..  .    . .  | .|..   . ||
kyfpdktreelkfGildverkefvkrniletrllelskGne.th
0049772 (Phosphotyrosine protein) phosphatases II 38-319 1.3e-46 155.2 In-house 35-280 (314) alignment 
Range on Protein: 38-319
Range on HMM: 35-280/314.0
RLTWVQSQKPENQMKNRFANVVAYDhSRVVLSlTENDQSSHYINANYVDTYnamNAYIATQGPLAKTISDF----------WRMI--WEQNCRVIVM---
.||........|. |||. ... .| .||.|. ... ..| ||||.|||..   ...|||||||  |. ||          |||.  ...|.|.|||   
eltilvadlflnrdknryldilpad.nrvilp.glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------ITNIIEKGRHKCAMYWPTKNrktenhgpltitfvqeetfayysirtfeikpnkdgthytqymhgtmfdssastnmlldesL-
                  .... ..| . .|..... .                                                              
evladelsrLdaAlgKtpllildgngneptaadlellk............................................................ee

--DPlddEVKPMMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKStacvvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIhdngDLDIFNFLAHIRNQRN--
  ||   |  . .. ... . .||..|| . .   .|..| .      .  ||..|||.||.||.| |.|.. ..|.     ....   |...|..|   
lydp...elferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpin

---HLVQEECQYIFIHDTLAEYI
   ....  .||.||.. | ||.
pnpgfieqleqyefilealleyl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 39-163 1.4e-29 97.9 In-house 23-147 (297) alignment 
Range on Protein: 39-163
Range on HMM: 23-147/297.0
LTWVQSQKPENQMKNRFANVVAYDHSRVVLSltENDQSSHYINANYVDTYN--AMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAM
 ..  ....    |||. ...|.| .|| |        . ||||.||   .  |   || .|||| .|. |||....||. |||||.... | ||.||| 
esfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPTKNRKTENHGPLTITFVQEETFAY
|||  . .  . | . . |. . .  .
ywpsvvqerlkagdvvveflsstsdef
0040439 (Phosphotyrosine protein) phosphatases II 41-320 7.6e-76 250.3 In-house 3-247 (249) alignment 
Range on Protein: 41-320
Range on HMM: 3-247/249.0
WVQSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPT
.  ...|||. |||. ....||||||.|| ...   | ||||.|.|.|.  ...||||||| .|..|||||.||....||||.|.  |.|| ||| |||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

knRKTENHGPLTITFVQEETFAYYSIRTFEIKPNKdgthytqymhgtmfdssastnmlldesldplddEVKPMMVKQFHFTGWPDHGAP-EPGFEFPVLD
  ... ..| .|.|....|....| .||.|.....                                 . .. .|.....|.|||||.|  .   .  ..
..ggsleygdftvtllsvevkddytvrtleltnly.................................dgesrtvlhiqytdwpdhgvppsfedlldfie

LIMKSTACVvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
...|  .   |  ||..|||||||||.|.||... |. ... ....|... ....|.||.. || . ||.|... |.|.. 
avrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0037934 (Phosphotyrosine protein) phosphatases II 41-319 2.3e-70 232.2 In-house 2-242 (243) alignment 
Range on Protein: 41-319
Range on HMM: 2-242/243.0
WVQSQKPENQMKNRFANVVAYDHSRVVLslteNDqsSHYINANYVDTYNamnAYIATQGPLAKTISD----FWRMIWEQNCRVIVMITNIIEKGRHKCAM
.  ...|||. |||. ....||||||.|    ..  | |||||... ..    .||||||| .|. |    ||||.||....||||.|. .|.|| |||.
fsiallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPtknRKTeNHGPLTITFVQEETFAYYSIRTFEIKpnkdgthytqymhgtmfdssastnmlldesldPLDDEVKPMMVKQFHFTGWPDHGAPE-PGFEF
|||    .. ..|..|.|...||....| .||....                                .|| .  . .| ..|...|||||.|. |    
ywp...gev.tygdftvtllseehlddytvrtllle................................nldlddltrlvihyhylpwpdhgvPdspedll

PVLDLIMKSTAC-----VVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIhdngDLDIFNFLAHIRNQRNH-LVQEECQYIFIHDTLAEYI
  || . .         . .. ||..|||||||||.|..|... |....    ..|... ....|.||..  || . ||.|... |.|..
dfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_CG7180_pd Subfamily CG7180 43-322 8e-60 197.0 In-house 36-293 (296) alignment 
Range on Protein: 43-322
Range on HMM: 36-293/296.0
QSQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRhKCAMYWPTKN
.  . ||. |||  .|| ||. ||||.  . ...|.|||| |||..   ..|| |..|  .|. .|||.......  .|..|.  .  . ..  ||| | 
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

rkTENHGPLTITFVQEETFAYYSIRTFEIKPNkdgthytqymhgtmfdssastNMLLDESLDPLDDEVKpmMVKQFHFTGWPD-HGAPEPGFEFPVLDLI
   |..|.. .  |.|...|   |||| .. .                      . | |   . . |..  .||.|..| |.  .  |     .  |   
..keqygeifveiveekqyanlkirtfkltkk.....................ivalteqekqvkaetR..ivklfqlteWeledkvPlstnalielrrr

MKSTACVV---PGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIACN
...    |   | .||.||..| |..|||... ||  .  .. .. .|.|...  .|..|..||..  .| .| |.| |.. ||
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 44-179 6.8e-44 144.9 In-house 4-136 (250) alignment 
Range on Protein: 44-179
Range on HMM: 4-136/250.0
SQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHkCAMYWPTKnr
..||.|. |||.|...|.|.|||||  .. |. | |||| ....|.  .|.||||||| .|| |||||..|..  .|||.||. |...  .  |||..  
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..

KTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTH
|.|..| .|..  ..|.|| | .|.. .  .|   .
kaekyGdvtvsllskeefadytkrklklskakkade
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 44-182 1.8e-39 130.9 In-house 20-153 (284) alignment 
Range on Protein: 44-182
Range on HMM: 20-153/284.0
SQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITniiekgRHKCAMYWPTKNR
.  ..|. |||. ...|.|...| |  .   . | |||| ..  |   . ||||||||  |. ||||||||.||  ||..|      ..||. ||| |  
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

KTENHGPLTITFVQEETFayYSIRTFEIKP---NKDGTHYTQ
..|... . .. |.|     | .| .|.     .||  . .|
ikeerfkvkvdsveesee..yvvrdielsedgkekdirkirq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 44-185 2.5e-32 106.6 In-house 38-179 (515) alignment 
Range on Protein: 44-185
Range on HMM: 38-179/515.0
SQKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNR
.|.  |  |||. |.. || .|| | . ...  | |.|| |. .... .||||.|||.  ...||||.....|   |.|.|.  |  . ||. ||| |  
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

KTENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYMH
.. . | . .  |  |. .   .|....  ..|    ||.  
dsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhf
0042113 (Phosphotyrosine protein) phosphatases II 45-319 2.1e-75 248.6 In-house 5-243 (245) alignment 
Range on Protein: 45-319
Range on HMM: 5-243/245.0
QKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknRK
..|||. |||. ....|||.||.|| ...|  | ||||.|||.|.  . .|||||||..|. |||||.||.....|||.|.  |.||.||| |||.  . 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

TENHGPLTITFVQEETFAYYSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddeVKPMMVKQFHFTGWPDHGAPE-PGFEFPVLDLIMK
. ..| .|.|.. ||....| .||.|.....|                                  .. .| ..|...|||||.|. .   . .|... |
sltygdftvtllseehlddytvrtlevtnlgd.................................desrevihyhylpwpdhgvpdllellldflefvrk

STACvvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYI
  |   .. ||..|||||||||.|.||... |. ... ........ ....|.|| . || . ||.|... |.|..
alae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 45-321 9.8e-51 167.3 In-house 29-268 (283) alignment 
Range on Protein: 45-321
Range on HMM: 29-268/283.0
QKPENQMKNRFANVVAYDHSRVVLSLTENdqssHYINANYVD---TYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTk
   ||. |||. ..|..|  || |    .    .|||| ..     |.  . ||..|.|| .|. |||.|.....   |||.|.. |  | ||. |||  
sadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk.

nRKTENHGPLTITFVQEETFAYYSIRTFEIKPNkdgthytqymhgtmfdssastnmlldesldplDDEVKPMMVKQFHFTGWPDHGAPEPGFEFPVLDLI
 | .|..|..|.|  .| |   ..|. . .. |                                    . ...  . . .| . |   .   .  ....
.rGsedyGeftvtlrkettsnsfiikelllrvn................................ssakstlllahyqvidWleygeqaiinslvkfnkv

mKSTACvVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIAC
 .|        ||.|||||.|.||...|| . . .| .  .  .|.|. .  .|.||  .||.  || ..|.   |   |
.islqt.eskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalc
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 45-173 1.1e-35 118.0 In-house 4-130 (239) alignment 
Range on Protein: 45-173
Range on HMM: 4-130/239.0
QKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNA-MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNR
.|  |. |||.||.|.||||||||    ||  | ||||.|.  |.   .||||||| .. .  |||||.|..   ||||.| .||  ..||  |||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

KTENhgpLTITFVQEETFAYYSIRTFEIKP
|  |   | .|. . | || | |||| .  
kycn...lrvtlrktevfadyiirtfvmsq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 45-173 1.1e-35 118.0 In-house 3-129 (239) alignment 
Range on Protein: 45-173
Range on HMM: 3-129/239.0
QKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYNA-MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNR
.|  |. |||.||.|.||||||||    ||  | ||||.|.  |.   .||||||| .. .  |||||.|..   ||||.| .||  ..||  |||    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

KTENhgpLTITFVQEETFAYYSIRTFEIKP
|  |   | .|. . | || | |||| .  
kycn...lrvtlrktevfadyiirtfvmsq
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 45-142 5.1e-25 82.7 In-house 33-131 (281) alignment 
Range on Protein: 45-142
Range on HMM: 33-131/281.0
QKPENQMKNRFANVVAYDHSRVVLSL-TENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKN
..| |. |||..|. . | ||| | .   | .|. || |||. .      || ||||  .| .|||||||..|   |||. ...|  | ||| |.| . 
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 45-145 7.8e-22 72.4 In-house 44-141 (305) alignment 
Range on Protein: 45-145
Range on HMM: 44-141/305.0
QKPENQMKNRFANVVAYDHSRVVLsltENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRK
.. ... |||. .|   |. || |   |.    .|| |||| |    . .| || || || .||| | ....   | |. |..||| .||. |...|...
keaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

T
.
v
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 45-184 3.7e-16 53.5 In-house 92-224 (244) alignment 
Range on Protein: 45-184
Range on HMM: 92-224/244.0
QKPENQMKNRFANVVAYDHSRVVLSltENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRhkcamYWPTKNRK
 .|.|  ||| .  . .| .|| ||  .   .  |||| .|        || || ||| |  |||.|. |.   |.|..  . |.       |||  .  
fnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdsepl

TENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYM
      .|.|. . . |       .||. . . .| .  |
ewyeeditvtltdrdefknikasnleiesdmneshqaltm
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 45-87 2e-08 28.0 In-house 43-85 (440) alignment 
Range on Protein: 45-87
Range on HMM: 43-85/440.0
QKPENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDT
  |.|..|||. |..|||||||.|   .   .|.|||| |.. 
slpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
ERO1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) 45-120 1.6e-06 14.6 Pfam-A 71-145 (357) alignment 
Range on Protein: 45-120
Range on HMM: 71-145/357.0
QKPENQMKNRFAN------VVAYDHSRVvlsLTENDQSSHyINANYVDTYNAMNAYIATQGPLAKTIsdfWRMIWEQNCRVI
.| |...|... .      |  .|  .     .| |....  .|.||| ..  ... . .|. |. .   ||.|.|.||  .
akdekelkesleevreskkvekldeldd...ycevddees.ekavyVdLlknperfTgYkGksaarv...WraiYeeNCfkk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 47-321 2.2e-65 215.5 In-house 26-270 (274) alignment 
Range on Protein: 47-321
Range on HMM: 26-270/274.0
PENQMKNRFANVVAYDHSRVVLSLTENDQ-SSHYINANYVDTYNA-MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRK
. .| |||. ...  ..|||.|.  ....  |.||||||.  |.   .||.||||||..|..||||||......||||.|.. |. ..|||.|.|...  
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--TENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHytqymhgtmfdssastnmlldesldplddevkpmmVKQFHFTGWPDHGAPEPGfeFPVLDLIM
  .|..| . |....  .   ||.|.. .|  ..  .                                   || . .| |||| .|.     ..|||..
eiserygdveikvekiverndysvrklvlkylerers...................................vkhywytdWPdhksPdda..ntlldlvl

K---STACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIAC
.   |       ..| |||||||.|| |.|| |.  ........ .|...  ...| .|  .||.. || .|| .|..|  .
eveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 47-316 1.4e-59 196.2 In-house 1-236 (237) alignment 
Range on Protein: 47-316
Range on HMM: 1-236/237.0
PENQMKNRFANVVAYDHSRVVLSLTENDqsSHYINANYVDTYNA-MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRkT
.||..|||..|.||||||||||  . ..  | ||||.|.. ..   . |||.||||  .  |||.|.|...| ||||.| .||. . ||  |||  ..  
senkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.p

ENHGPLTITFVQEETFAYYSIRTFEIKPNKDGThytqymhgtmfdssastnmlldesldplddEVKpmMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKST
. .| ||... ..| |. |..|.. .  .                                  ||.  ...|..|| |||.| |.    .  .   .   
aaygvltvslkkkeefsdytvrslllskrltlk..............................evr..lihqyqftswpdrgvpqqtaallrfrkniinr

ACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLA
.  |. .|| ..||||||||.| |.|||.|... ...  .||.|..  | ..| ...| . ||.|||.|. 
sphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_CG42327_pd Subfamily CG42327 47-173 4.6e-29 96.1 In-house 26-155 (319) alignment 
Range on Protein: 47-173
Range on HMM: 26-155/319.0
PENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVDTYN-AMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNR--
.  . |.|..|||   ..||||    .|....|..|.||  |. | | |||.| .| .. |||||..|||. |||| .|.. |.| ..|| |.|||.   
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

KTENHGPLTITFVQEETFAYYSIRTFEIKP
 |. .| . .|. . |.   | | |. .| 
ntslyGdilvtlkgrevkdryaistlllkr
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 47-178 7.1e-10 32.1 In-house 25-120 (169) alignment 
Range on Protein: 47-178
Range on HMM: 25-120/169.0
PENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINAnyvdtynamnayiatqgplaktisdfwRMIWEQNCRVIVMITNIIEKgrhkcAMYWPTKNRKtE
  |. ||| |  .|  | || |    .| .| ||||                           ||||| |  |||.. .  .|       .|| |.   .
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpekedy.q

NHgPLTItFVQEETFAYYsIRTFEIKPNKDGT
 | |  | . .  | . | .||  ...| .| 
lh.pavi.lgewytdsly.vrtdkvhantsgv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 48-320 1.6e-37 124.0 In-house 46-345 (350) alignment 
Range on Protein: 48-320
Range on HMM: 46-345/350.0
ENQMKNRFANVVAYDHSRVVLS--------LTENDQSSHYINANYVDTY------NAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHK
|   |||. |.. |.|||| |              ... ||||||.         |.   |||||.|| .|. ||...| . . .||...|. .| ...|
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CAMYWPTKNRKtENHGPLTITFVQEETFAYYSIRTFEIKPNKD-GTHYTQYMHGTMFDSSASTNMLLDEsldplddevkPMMVKQFHFTGWPDHGA-PEP
|  ||.  . . . .  |. .  .       |......| .       ..  .   ..|  . ..   .          |..| |...  |.| .   .|
cyrYWqegsyd.ditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasd..........PyvvyqlqvknWkDlslllnP

GFEFPVLD----LIMKSTA---CVVPGTGPLVVHCSAGVGRSGAFIVIDSMIK------RIHDN-GDL--------DIFNFLAHIRNQRNHLVQEECQYI
    ..|.    || . .|        . |..||||||||| | .. .||...       . ..   |         |.  . ..|.||  .||.  |.|
esilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfi

FIHDTLAEYIA
||...|  | |
fiYeallfyfa
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 48-185 9.7e-36 118.1 In-house 19-159 (270) alignment 
Range on Protein: 48-185
Range on HMM: 19-159/270.0
ENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINANYVD-TYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRK--
 ..  ||.|...   ..||.|.  |.|. . |||||||    .. ..|||..|||. |...|||||||.. . |||.|.. ||||.||..|||... .  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

TENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHYTQYMH
. ..| .... ..||    | ..  ... . .  . . ...
kledgkikvlalseekeegyiltrlrleekgeerrlvHfwy
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 48-159 2.2e-26 87.1 In-house 51-160 (310) alignment 
Range on Protein: 48-159
Range on HMM: 51-160/310.0
ENQMKNRFANVVAYDHSRVVLSLTEnDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNrKTEN
..  |||...||  | ||| | .    .   || |||| |    ...| .|||| .|| ||||||... .  |... .. |.|| ||  |||.    || 
kymhknrysdvvcldtsrvklkidk.sryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg.vtet

HGPLTITFVQEE
.| . .| . | 
ygcirvtnlses
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 48-124 1.2e-15 51.9 In-house 46-115 (303) alignment 
Range on Protein: 48-124
Range on HMM: 46-115/303.0
ENQMKNRFANVVAYDHSRVVLSltendqSSHYINANYVDTyNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMIT
.|  ||||..|.  |||.| ||       | || |.|..  .. .  | || ||..| .|||.|| ||. ...... 
knmdknrfvdvicldhskvkls......dssyihasylel.dsskkailtqlplshtaadfwqmiieqkvkcvllll
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 48-125 2.8e-12 40.8 In-house 36-118 (347) alignment 
Range on Protein: 48-125
Range on HMM: 36-118/347.0
ENQMKNRFANVVAYDHSRVVLSlTE------NDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITN
 .  |||  .|   | .|||||  |       |..  |||| ..   || . || || || .|. |||.|.   .   .| | .
kslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 48-179 5.9e-10 32.2 In-house 25-120 (169) alignment 
Range on Protein: 48-179
Range on HMM: 25-120/169.0
ENQMKNRFANVVAYDHSRVVLSLTENDQSSHYINAnyvdtynamnayiatqgplaktisdfwRMIWEQNCRVIVMITNIIEKgrhkcAMYWPTKNRKtEN
 |. ||| |  .|  | || |    .| .| ||||                           ||||| |  |||.. .  .|       .|| |.   . 
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpekedy.ql

HgPLTItFVQEETFAYYsIRTFEIKPNKDGTH
| |  | . .  | . | .||  ..||  | .
h.pavi.lGewytdsly.vrtdkvhpntsgve
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 48-173 7.6e-10 33.4 In-house 18-152 (290) alignment 
Range on Protein: 48-173
Range on HMM: 18-152/290.0
ENQMKNRFANVVAyDHSRVVLSLTENDQSSHYINANYVDTYNAMnAYIATQGPLAKT-------ISDFWRMIWEQNCRVIVMITNIIEKGRH----KCAM
...|..| .. ..  ..||||    .  .. || ||.|   | . . |.|| |..|.       | .|| |. . . . .||. .  || ..     || 
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCak

YWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKP
| |..  .  . . ||.   . |.     .|. ..| 
YvpesvgeelkfkgltvkCkskekeddvetRelvvkf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 48-142 1.2e-06 22.2 In-house 50-142 (302) alignment 
Range on Protein: 48-142
Range on HMM: 50-142/302.0
ENQMKNRFANVVAYDHSRVVLSltenDQSSHYINANYVDTYNAMNAYIATQGPLAKTI---SDFWRMIWEQNCRVIVMITNIIEKGRhKCAMYWPTKN
.|  ||.  .| ..|. .| |.     .  .|.||  |.  .  .  | .| |  ..     .||||......  .|..    |  .     ..|.| 
knlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks
Y_phosphatase Protein-tyrosine phosphatase 49-317 3.1e-78 257.8 Pfam-A 1-235 (235) alignment 
Range on Protein: 49-317
Range on HMM: 1-235/235.0
NQMKNRFANVVAYDHSRVVLslTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENH
|. |||. ....||..|| |  ......| |||||||..|.  ...||||||| .||.|||||.|.....||||.|.  |||| ||| |||.........
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPLTITFV-QEE-TFAYYSIRTFEIKPNKDGThytqymhgtmfdssastnmlldesldplddevKPMMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTA
| .... . .|.   . | .|..|.| .|. .                                .. .|||.|.|.|||||.||     ..|||| |   
gdikvelkekekedekeytlrklelkkkkees................................ekrevkqlhytnWpdhgvpes..pkslldlirkvek

CVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAE
   . .||.||||||||||.| |...| ...........|..... ..|.||...||.. ||||......|
skeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 49-317 3.1e-78 257.8 In-house 1-235 (235) alignment 
Range on Protein: 49-317
Range on HMM: 1-235/235.0
NQMKNRFANVVAYDHSRVVLslTENDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENH
|. |||. ....||..|| |  ......| |||||||..|.  ...||||||| .||.|||||.|.....||||.|.  |||| ||| |||.........
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPLTITFV-QEE-TFAYYSIRTFEIKPNKDGThytqymhgtmfdssastnmlldesldplddevKPMMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTA
| .... . .|.   . | .|..|.| .|. .                                .. .|||.|.|.|||||.||     ..|||| |   
gdikvelkekekedekeytlrklelkkkkees................................ekrevkqlhytnWpdhgvpes..pkslldlirkvek

CVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAE
   . .||.||||||||||.| |...| ...........|..... ..|.||...||.. ||||......|
skeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 49-323 4.4e-49 161.8 In-house 1-175 (182) alignment 
Range on Protein: 49-323
Range on HMM: 1-175/182.0
NQMKNRFANVVAYDHSRvvlsltendqSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITniiekgrhkCAMYWPtknrktenh
|. |||. ... |||||           ..|||||... .   . .||||||| .|. ||.||..|.....||..|         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gpltitfvqeetfayysirtfeikpnkdgthytqymhgtmfdssastnmlldesldplddEVKPMMVKQFHFTGWPDHGAPEpgfEFPVLDLIMKSTAcv
                                                            |  . .. |.....|||||.|.      .||.| .  .  
............................................................ellerlgiqylylpwpDhgvpd...ldelldfieevle..

vpGTGPLVVHCSAGVGRSGAFIVIDSMIKRihdngDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIACNF
    || .|||||||||.|...... |.|.     ...... ....|..|.. |. . ||.|... | |.. .. 
..eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 49-321 6e-36 118.9 In-house 43-273 (288) alignment 
Range on Protein: 49-321
Range on HMM: 43-273/288.0
NQMKNRFANVVAYDHSRVVLSltenDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENH
|  ..|. |.   | .|| ||    | .  ||.|| | . .  .  | .| ||  ||  .|.|. |.. . |||.....|||..| | |.|.|  ..   
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GPLtitfvqeetfayysirtfeikpnkdgthyT---QYMHgtmFDSSASTNMLLDESLDPLDDEVkpmMVKQFHFTGWPDHGAPEPgFEfPVLDLIMKST
| |                                 .  .    |     .. |     . ...|   .||. |.  |.|.| ||  .  . | |.    
grl.............................ctvvkkkr...adidklvkvsllriskegeekv...ivkilhlleWdddgvPen.yl.splrllevlk

ACvvpgTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIAC
..    . |.|||.||||||.|..|.|  ... .  . .| | ..||. |..| . .| | ||...|  . |... 
sl....qkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 49-320 3.8e-23 76.4 In-house 48-345 (349) alignment 
Range on Protein: 49-320
Range on HMM: 48-345/349.0
NQMKNRFANVVAYDHSRVVLSL------------TEND--QSSHYINANYVD--TYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRH
   |||. ... |.||||.|              .| |  .  .||||||.    ... . ||||| ||  |. ||...|  .. .... ...  |.. .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCAMYWPTKNRKtENHGPLTITFVQEETFAYYSIRTFEIKPNKDGTHY-TQYmhGTMFDSSASTNMLLdesldpldDEVKPMMVKQFHFTGWPDHGAPEP
|| .||   . . . .  |  .. .       | | .. | ...  .   .       |    ...||        .. || .. |. .  |.| .    
kcdiywqelsys.nitvklqnsslyianvqGnslrvstvkdtdndndnnkkn..Cdlpddddddaill........avekPyellqlqvknwldlsllln

GFE--------FPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIK----RIHDNGDLD--------IFNFLAHIRNQRNHLVQEECQYIFI
             ..|  .         . .|.|||||| ||.| .. .|...       ..   ..        |.  . ..| ||  .||.  |.|.|
PisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiai

HDTLAEYIA
...| .|.|
yealLkyfa
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 49-142 3.2e-20 67.0 In-house 55-146 (305) alignment 
Range on Protein: 49-142
Range on HMM: 55-146/305.0
NQMKNRFANVVAYDHSRVVLSlteNDQSSHYINANYVDTYNA-MNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKN
.. |||...| . |.| | |.   . . |.|| ||||       . .|..|||| .|| .|| |. ...   |||. . .| |. ||| |||. .
aitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 49-185 3.2e-19 64.0 In-house 35-170 (285) alignment 
Range on Protein: 49-185
Range on HMM: 35-170/285.0
NQMKNRFANVVAYDHSRVVLSLTENDqsshYINANYVDTY-NAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTEN
|   ||.|.| . . .||||   . |    || |...    .  ..||.||||| .|.||||.||....   ..|.  ..| |  |||.|.| |  .  .
npdlnryadvrcieetrvvlknhdrd....yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

HGPLTI--TFVQEETFAYYSIRTFEIKPNKDGTHYTQYMH
 |   |  | ..||. |   . .. .   .| .    || 
fgkyeitlteckeeaiagtilnaltvintedasseplymn
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 49-134 2.8e-12 40.8 In-house 34-118 (332) alignment 
Range on Protein: 49-134
Range on HMM: 34-118/332.0
NQMKNRFANVVAYDHSRVVLslTENDQSSHYINANYVDTYNAMNAYIATQGPLAK-TISDFWRMIWEQNCRVIVMITNIIEKGRHKC
|   ||   . ..||||| |  . .|    . ||..|| |.  .||| .| |.   |   ||||. |..  .|... .| || ..|.
nmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 50-181 1.1e-26 88.1 In-house 57-184 (290) alignment 
Range on Protein: 50-181
Range on HMM: 57-184/290.0
QMKNRFANVVAYDHSRVVLSlteNDQSSHYINANYVDTYNAMnaYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHG
  |||. .||  | .||.|.   . .   |. ||||.  .||  .| |||.|..|. |.|||. ...  .|||. ..||.|. ||. |.| |. ..   |
fkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

PLTITFVQEETF-AYYSIRTFEIKPNKDGTHYT
 .|..  .|..  |    .|. ..  ..| .. 
eitvlcseeddkdaniikktlsvrdkdsGkehk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 52-166 1.1e-15 52.2 In-house 53-164 (301) alignment 
Range on Protein: 52-166
Range on HMM: 53-164/301.0
KNRFANVvAYDHSRVVLSLTenDQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPL
|.|. .|   . |  |  ..  |     | ||...|    . .||||||| .|  ||| |.   .   |||... .||  .||. | |.| ... . |  
khryptv.PckPstaveviv..dGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

TITFVQEETFAYYSI
.|. ...|.    .|
kikiknkelilnkki
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 53-138 1.9e-12 41.5 In-house 47-128 (312) alignment 
Range on Protein: 53-138
Range on HMM: 47-128/312.0
NRFANVVAYDHSRVVLSLTENdqssHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYW
||. |.  .|  |  |.  ||     || ||.|      . ...||||| .|.. ||..     .  |.... ..| | .||| | 
nrypniqcwdrgrftlagden....fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi
0044763 (Phosphotyrosine protein) phosphatases II 61-316 3.2e-35 116.7 In-house 2-168 (178) alignment 
Range on Protein: 61-316
Range on HMM: 2-168/178.0
YDHSRVVLSLTENDQSSHYINANYVDTYnamnAYIATQGPlaktiSDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRktenhgpltitfvqeet
.|..||.||  |. ..| ||||.... .     |.....|     .|......|.....||..|. .| |..||  |||...                  
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

fayysirtfeikpnkdgthytqymhgtmfdssastnmlldesldplddevkpmmvKQFHFTGWPDHGAPE-PGFEFPVLDLIMKSTAcvvPGTGPLVVHC
                                                        |......||||.|. . . . ....| .  .   .  || .|||
.......................................................iqylhipipDhgvpdllehflefvefieeald...ekggpvlVHC

SAGVGRSGAFIVIDSMIKRihdngDLDIFNFLAHIRNQRNhLVQEECQYIFIHDTLA
||||||||...... |.|.     .|.... ....|..|.  |. . |. ....   
saGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefel
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 61-183 4.3e-11 37.2 In-house 5-114 (130) alignment 
Range on Protein: 61-183
Range on HMM: 5-114/130.0
YDHSRVVlsltendqSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRhkcamYWPTKNRKTENHGPLTITFVQEET
.. ||.           .||||..|   .  . |. || |||.|  |||.|. |.   |.|..  . |.       |||  .        ...|  . . 
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrde

FAYYSIRTFEIKPNKDGTHYTQY
| .     .||. .   .| .  
fknikasnleiesdlneshqalt
0046846 (Phosphotyrosine protein) phosphatases II 72-318 1.6e-41 137.3 In-house 7-172 (176) alignment 
Range on Protein: 72-318
Range on HMM: 7-172/176.0
ENDQSSHYINANYVDTYnamnAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknrkTENHGPltitfvqeetfayysirtfei
  | ...|||||.....    ..||||||| .|. ||..|..|......|..|. .|.||.||. |||      |..|                      
gldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi.....................

kpnkdgthytqymhgtmfdssastnmlldesldplddevkpmmvkQFHFTGWPDHGAPEPGFEFPVLDLIMKstacVVPGTGPLVVHCSAGVGRSGAFIV
                                             |.....|||||.|.    . .|..| .    ..   || .||||||.||.|....
.............................................qylhlpwpDhgvpdlelllellefire....alkeggpvlVHCsaGigRtgtlva

IDSMIKrihdNGDLDIFNFLAHIRNQRN-HLVQEECQYIFIHDTLAEY
.. ...    . .|.... ||..|.||  . || ..|| |... . ..
ayllel....ekglsveealalvreqRplgavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 74-312 4e-42 139.2 In-house 2-154 (172) alignment 
Range on Protein: 74-312
Range on HMM: 2-154/172.0
DQSSHYINANYVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIiekgrhkcamywptknrktenhgpltitfvqeetfayysirtfeikp
|..|.||||.|.|.|  .. .|||||||  |..|||||..|.....||..|.                                                
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

nkdgthytqymhgtmfdssastnmlldesldPLDDEVKPMMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKSTacVVPGTGPLVVHCSAGVGRSGAFIVID
                                .| |    .. |.....|||||.| . .   .|..| .    ..   || .|||||||||.|......
...............................lydpellerlgiqylylpwpDhgvpllellleflefidell..alspggpvlVHCsaGvgRtgtlvaay

SMIkrihdnGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
 |.       .|.... .|..|..|.. || . ||.|..
lml......lglsleeavalvrekRpgavqnpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 77-320 4.4e-47 156.3 In-house 4-226 (272) alignment 
Range on Protein: 77-320
Range on HMM: 4-226/272.0
SHYINANYVDTYNA---MNAYIATQGPLAKTISDFWRMiWEQNCRVIVMITNIIEKGRHKCAMYWP----------TKNRKTENHGPLTITFVQEETFAY
|.||||..|..|.     .......|||  |. ||||. .|.....||....  |.||.|| .|||               | ..| |..|...||.. .
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YSIRTFEIKPNKDgthytqymhgtmfdssastnmlldesldplddEVKPMMVKQFHFTGWPDHGAPEPGfEFPVLDLIMKstacvvpgTGPLVVHCSAGV
| .|.....   .                                  ....| ..|.|.|||||.|.      .|.|. .         ||..||||||.
yilrellltllls................................agearevmhlhytdwpdhgvpqea.llellellld........ggpvlvHCsaGk

GRSGAFIVIDSMIKRIHDNGDLD--------IFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
.|.| ..... .. .....  .|        ........| || . || | ||.|... |.|.. 
dRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellr
0036282 (Phosphotyrosine protein) phosphatases II 77-313 1.7e-44 146.9 In-house 2-164 (174) alignment 
Range on Protein: 77-313
Range on HMM: 2-164/174.0
SHYINANYVDTYNAMNAYIATQGPLAktisdFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTknrktenhgpltitfvqeetfayysirtfeikpnkd
|.||||...| .   . .||.|||||     ||.|..|......|| .. .|.|..||  |||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

gthytqymhgtmfdssastnmlldesldplDDEVKPMMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKSTACvvPGTGPLVVHCSAGVGRSGAFIVIDSMI
                              . |    .. |.....|||||.|.    . ..... .  .   .. ||..|||||||||.|...... |.
..............................lredlerlgiqylylpwpDhgvpdlsillefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylml

KRIHdNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
.... ..  |...... .|.|| . || . ||.|...
rgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 77-314 3.2e-31 103.3 In-house 3-148 (151) alignment 
Range on Protein: 77-314
Range on HMM: 3-148/151.0
SHYINANYVDTYnamnaYIATQGPLAktisDFWRMIWEQNCRVIVMITNIIEKGrhKCAMYWPTKNrktenhgpltitfvqeetfayysirtfeikpnkd
|.|||..||. .     .....||||    ||.....|.....||....  | |  .|. |.|  .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

gthytqymhgtmfdssastnmlldesldplddevkpMMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKStacvvPGTGPLVVHCSAGVGRSGAFIVIDSMI
                                    . |.......|||.| |.   ..  .  .. .     .. ||..||||||.||.|...... |.
....................................ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml

KRihdngdLDIFNFLAHIRNQRNHLVQEECQYIFIHDT
 .      ....  |...| .| ..|| . |..|..  
lg......vsleealeeyrlkrpgvvqpnqqflfqlfa
0049260 (Phosphotyrosine protein) phosphatases II 84-313 3.8e-41 135.6 In-house 1-144 (152) alignment 
Range on Protein: 84-313
Range on HMM: 1-144/152.0
YVDTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWptknrktenhgpltitfvqeetfayysirtfeikpnkdgthytqy
..| |. ....||||||.  |..|||||..|.....|||.|.  |.|. ||..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

mhgtmfdssastnmlldesldplddevkpmmvkQFHFTGWPDHGAPEPGFEFPVLDLIMKSTacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIkrihdnG
                                 |.... |||||.|.  . .. | |...         || .|||||||||.|...... |.       
.................................qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......l

DLDIFNFLAHIRNQRNHLVQEECQYIFIHD
........|..|..|.. |. . |..|...
gvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 86-177 6.4e-15 49.4 In-house 230-317 (440) alignment 
Range on Protein: 86-177
Range on HMM: 230-317/440.0
DTYNAMNAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKgrhKCAMYWPTKNRkTENHGPLTITFVQEETFAYYSIRTFEIKPNKDG
. |   ||.|||| ||  |. ||||.. . .   |.|. .. .|    |..||| . | .   ||.|.     | .    .||.|.| ... 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntr.svtfgpftvghkgsenmnrvkvrtlelkykeev
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 92-174 3.8e-12 40.8 In-house 5-87 (199) alignment 
Range on Protein: 92-174
Range on HMM: 5-87/199.0
NAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPN
  ||||| || .|..|||.|.||     |||. .   .     ..|||| .  | ..| |..|     | . |.| .. .  |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnn
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 92-174 3.9e-12 40.7 In-house 4-86 (198) alignment 
Range on Protein: 92-174
Range on HMM: 4-86/198.0
NAYIATQGPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETFAYYSIRTFEIKPN
  ||||| || .|..|||.|.||     |||. .   .     ..|||| .  | ..| |..|     | . |.| .. .  |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnn
subfamily_hpo-7_pd Subfamily hpo-7 93-320 5.5e-14 46.7 In-house 39-228 (263) alignment 
Range on Protein: 93-320
Range on HMM: 39-228/263.0
AYIAtqgpLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQEETfaYYSIRTFEIKP---NKDGTHYTQYMhgtmf
 |.     | .||  |...|  ..  |.||...  |.|. ||  |.|..  .      ....  .        ..| |.     .|  ||  .       
lysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhy.....

dssastnmlldesldplddevkpmmvkqfHFTGWPDHGAPEPGFEfpVLDLImKstacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIK----RI--HDNG
                              ..||... .||   |  .| .. |    |. .  .||||||.|.||| || |.... .     .   . .
.............................sykgWiekndpelare..ilnil.k....varnskslvvhcstGiGrsaafsvaElvyqkmirsldttstv

DLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
.||  ..| ..|..|.  ...  |  |   .. ... 
eldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 96-172 3.9e-07 24.4 In-house 39-106 (255) alignment 
Range on Protein: 96-172
Range on HMM: 39-106/255.0
AtqgplakTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKTENHGPLTITFVQeeTFAYYSIRTFEIK
        |.  |...|  ..  |.||...  |.|. ||  |.|..  .      ...|  .  . |   .|| || 
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleit
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 99-311 6.6e-21 69.0 In-house 98-280 (302) alignment 
Range on Protein: 99-311
Range on HMM: 98-280/302.0
GPLAKTISDFWRMIWEQNCRVIVMITNIIEKGRHKCAMYWPTKNRKtenhgpltitfvqEETFAYYSIRTFEIKPNKDgtHYTQYMHGTMFDSSASTNML
 |  .|.  .| .| . |  ..| .....|.. .||| |. .| ..             | .|  |...| ..| . .  ..|   . ...      .  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgg.............elkfgrytvktvsvktdle..eftdkksfklytveiknekk

LDEsldplddevKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLIMkstACVVPGTgPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQR
 ..         ... |. ..|..|||||||.     . ||..     |    .  ..|||||||||.|... |   |.    .   |. . .  .|. |
kkk.........vkktvdilafsawpdhGapkea..ytaldilk...fcesykk.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcr

NHLVQEECQYIFI
   ||.| | |..
yGavqdeqqliyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 203-337 8.3e-37 121.9 In-house 168-300 (319) alignment 
Range on Protein: 203-337
Range on HMM: 168-300/319.0
LDPLDDEVKPMMVKQFHFTGWPDHGAPEPGFEfpVLDLIMKSTAC-VVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHL
|... .||.  .||.|..| ||||. || .    .|||. .       .  ||.|||||||||| |.|||.| |. |.. .| ||.|..  ..| ||| .
lnkkssevetRevkhfqyteWpdhdvPekats..lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnim

VQEECQYIFIHDTLAEYIACnFVISLPIKALKDHVR
||.. ||.||...| |.. . .   . .. |.| ..
vqrpeqYkfiyealleavea.gdteievqdlrdrlk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 207-341 9.1e-42 138.2 In-house 169-301 (318) alignment 
Range on Protein: 207-341
Range on HMM: 169-301/318.0
DDEVKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLIMKSTACV-VPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEE
..| .  .|.|.|.| |||.| || |    .|||. ....    .|.||.|||||||||| | ||..|....||.... .|.|..  ..|.||| .|| |
teeeesrqvrqyhytsWpdegvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqte

CQYIFIHDTLAEYIACnFVISLPIKALKDHVRMMRM
 ||.||.|.| |..|. .      . |....| .| 
dqyefiydvllealas.gdtevdasdlrsrirelre
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 207-325 1.8e-16 54.9 In-house 161-276 (285) alignment 
Range on Protein: 207-325
Range on HMM: 161-276/285.0
DDEVKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLiMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEEC
|   .|. ... .   |||. |||     |...|  |    | |   |..|||||||||. .|. ||    || .| ...... .  .|  | . ||   
dasseplymnhvqvpwwpdqlapeda..rpmiel.ykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshm

QYIFIHDTLAEYIACNFVI
|..|..  | ||.  . |.
qflflyvvlmeyfigegvv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 207-318 1.9e-10 34.9 In-house 161-268 (281) alignment 
Range on Protein: 207-318
Range on HMM: 161-268/281.0
DDEVKPMMVKQFHFTGWPDHGAPEPGfEfPVLDLIMKSTACvvpgTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDL-DIFNFLAHIRN-QRNHLVQE
  | .  .. .. .  |||   ||   |  .| .. |  |     . | |.||||||||||... ..  .. ||    | || . ..|.|   |   || 
syegetrlithwlwkewpdwqvpess.e.vmlkilrkirar....stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqt

ECQYIFIHDTLAEY
  ||..|   | ..
lqqymliwkvlldf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 208-320 1.7e-26 88.0 In-house 165-277 (281) alignment 
Range on Protein: 208-320
Range on HMM: 165-277/281.0
DEVKPMMVKQFHFTGWPDHGAPEPGFEFpvLDLIMKSTACVVPGT-GPLVVHCSAGVGRSGAFIVIDSMIKRIHDN-GDLDIFNFLAHIRNQRNHLVQEE
.. ..  |.|...| |||||.|.   |.  |.   . . .  . |  |||.||||||||.|..| .| ..|.....  .||. . .|..|..|| .||  
esgetreveqlaytaWPdhGvPattkel..lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv

CQYIFIHDTLAEYIA
 || |.. .. ... 
vqyefvykavldald
0048179 (Phosphotyrosine protein) phosphatases II 208-313 5.9e-21 70.1 In-house 42-139 (144) alignment 
Range on Protein: 208-313
Range on HMM: 42-139/144.0
DEVKPMMVKQFHFTGWPDHGAPEP-GFEFPVLDLIMKSTAcvvpGTGPLVVHCSAGVGRSGAFIVIDSMIkrihdN-GdLDIFNFLAHIRNQRNHLVQEE
 |    .. |.....|||||.|.   .   .|..| .  .      || .|||||||||.|...... |.       | |.... ||..|..| . |. .
pefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrpgavpnp

CQYIFIHD
 |..|...
gqlrfLle
PTEN_1 208-270 3.9e-06 21.8 In-house 88-148 (196) alignment 
Range on Protein: 208-270
Range on HMM: 88-148/196.0
DEVKPMMVKQFHFtGWPDHGAPEPGFEFPVLDLIMKSTACVVPgTGPLVVHCSAGVGRSGAFI
.| . . |.. || ...|||||   . | ... .. .     .  .  .||| ||.||||  .
eeffksgveylhf.pieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvv
subfamily_PTPRA_pd Subfamily PTPRA 209-341 1.1e-34 114.8 In-house 187-316 (330) alignment 
Range on Protein: 209-341
Range on HMM: 187-316/330.0
EVKPMMVKQFHFTGWPDHGAPEPGFefPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
| |. .|.|||||.||| | |  .    .|.|. |  ..    .||.||||||||||.|.|||.|....|.. .. .|.|.|. ..|.|| ..|| . ||
ekksrlvrqfhftswPdvGvPfepi..GmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy

IFIHDTLAEYIACNfVISLPIKALKDHVRMMRM
 ||. .| ||        | . .|. |.. .  
efiykvlleyylyg.dteldvsslekhlqklyn
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 209-339 8.7e-33 108.8 In-house 174-302 (305) alignment 
Range on Protein: 209-339
Range on HMM: 174-302/305.0
EVKPMMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTG-PLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQ
. .   | |...| ||||| |.  |   .|.|| . .     . | ||.|||||||||.|.||..| .. |..  . .|.|. | ..|..|  .||.  |
dkesrtvlqyqltdWPdhGvpq..fatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldq

YIFIHDTLAEYIACNfVISLPIKALKDHVRMM
| |.|| |.|.| |    |. .. |. .|  .
Yvflhdaldelitcg.dtsiigsnlrarvnkl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 209-319 7e-32 105.6 In-house 171-279 (288) alignment 
Range on Protein: 209-319
Range on HMM: 171-279/288.0
EVKPMMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
. . . ..|.....||||| ||   . |.|.|. .        |||..|||||||||.| ||..| .|.... .  .|.....|..|.||. |||.. ||
kkteleitqyqylaWpdhgvPes..kapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqY

IFIHDTLAEYI
.||...|.. |
efiyevllsli
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 209-320 1.7e-21 71.2 In-house 170-280 (439) alignment 
Range on Protein: 209-320
Range on HMM: 170-280/439.0
EVKPMMVKQFHFTGWPDHGAPEPGfeFPVLDLIM-KSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQ
  |   | |||.. |||.  |       |||..    .|     .||.||||||||||.|. | .|  ..... .  .||   .  .|.||...||. ||
tekertvlqfhyiawpdknvpaqa..shvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcq

YIFIHDTLAEYIA
|.||.... | | 
yvfiynavlediv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 209-315 1.8e-09 31.6 In-house 186-286 (310) alignment 
Range on Protein: 209-315
Range on HMM: 186-286/310.0
EVKPMMVKQFHFTGWPDHGAPEPGFEFPVLDLImkstACVVpgTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
..| . |.  ..  ||| | |.         |.    | |    || |||||||..| .. . ..  |....    .|. .  ......|   .| | ||
nlkelrvslikwpnwpdrgvpdekchtvpqrll....aqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqy

IFIHDTL
..|.   
liidrvr
subfamily_PTPRB_pd Subfamily PTPRB 210-319 2.6e-33 110.3 In-house 176-285 (293) alignment 
Range on Protein: 210-319
Range on HMM: 176-285/293.0
VKPMMVKQFHFTGWPDHGAPEPGFefPVLDLIMKST--ACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQ
 . . |.|.||| ||||| ||     ..||.. .    .     ..|.||||||||||.|.|| .| ....|...  .||| ..|..|..||.||| | |
keerkvrqyhftsWpdhgvPektk..tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq

YIFIHDTLAEYI
|||||... ...
Yifihqcvldll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 210-322 4.7e-25 83.1 In-house 170-281 (287) alignment 
Range on Protein: 210-322
Range on HMM: 170-281/287.0
VKPMMVKQFHFTGWPDHG-APEPGFEFPVLDLIMKSTacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
 .. .|||...| |...|  .||   . |..  .|.     .| ...|||||..||||. |. ..  |.. . .| .|.|. | . | |. . ||   ||
gdkqqvkqyqitnWdstgkvtepqtillvieemyktq..rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqy

IFIHDTLAEYIACN
.|| | . ||. . 
kfindivleyldsf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 210-318 7.3e-15 49.4 In-house 180-282 (290) alignment 
Range on Protein: 210-318
Range on HMM: 180-282/290.0
VKPMMVKQFHFTGWPDHGAPEPGFEfpvldlIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYI
 |  ..| ..   |||.  .   .       ...    .   .||.|||||||.||.|.|. |.  .. . |  .||. .    .|| |   || . ||.
Gkehklkhlkikswpdksvalstla......llrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyl

FIHDTLAEY
 . . | ..
alveilldl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 210-310 2.7e-13 44.3 In-house 178-272 (301) alignment 
Range on Protein: 210-310
Range on HMM: 178-272/301.0
VKPMMVKQFHFTGWPDHGAPEPGFE-FPVLDLIMKSTAcvvpgtgPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
...  |  . .. |.|.| |.   | | ...|. ||         |.|||||||.||| |||  . . .... .  ... . |.|.|..| . || . | 
fatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql

IF
 .
yw
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 211-321 1.1e-33 111.8 In-house 183-292 (298) alignment 
Range on Protein: 211-321
Range on HMM: 183-292/298.0
KPMMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTAcVVPGTG--PLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
|  .|.|.||| |||.|.||   .  ||||. |  |     .|  |..|.|||||||||.||.|||.. |.. .  .|.|. .  .|..| ..|| | ||
kerevrqlhftsWpdkgvpen..atsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqY

IFIHDTLAEYIAC
.||..   |....
vfiyeavlealds
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 211-321 8.5e-33 108.6 In-house 135-244 (250) alignment 
Range on Protein: 211-321
Range on HMM: 135-244/250.0
KPMMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVP-GTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYI
.  .|.|.||. ||| | ||      ||.|. |  |     |..|..|.||||||||||||.||....|.. .  .|.|...  .|..| | |. . ||.
derivrqlhfvvWPdkgvPe..vatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyv

FIHDTLAEYIAC
|..  . ... .
fvyeiilkalds
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 211-320 1.4e-22 74.9 In-house 176-284 (290) alignment 
Range on Protein: 211-320
Range on HMM: 176-284/290.0
KPMMVKQFHFTGWPDHG-APEPGFEFPVLDLIMKSTacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYI
.. .|.|...| |...|  ..|     |.  ..|      .| ...|||||..||||. |....  |.. . .|  |.|. | . | |.  .|| . || 
akqsvtqyqitnwdstgkvtnpqtillvieemyktq..rkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyq

FIHDTLAEYIA
.|.. . .|. 
gifqivltyld
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 211-314 1.2e-11 39.2 In-house 114-216 (255) alignment 
Range on Protein: 211-314
Range on HMM: 114-216/255.0
KPMMVKQFHFTGWPDHGAPEPGFEfpVLDlIMKstacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIK----RI--HDNGDLDIFNFLAHIRNQRNHLVQE
|   || ....||... |||   |  .|  |.|    ||  . ..|||||.|.||| ||...... .     .   . ..||  ..| ..|..|.  ...
kthtvkhysykGWieknaPelare..iln.ilk....vvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht

ECQYIFIHDT
  |  |   .
Plqlafsilm
0048076 (Phosphotyrosine protein) phosphatases II 212-317 4.9e-21 70.4 In-house 44-141 (145) alignment 
Range on Protein: 212-317
Range on HMM: 44-141/145.0
PMMVKQFHFTGWPDHGAPEP-GFEFPVLDLIMKSTACvvpGtGPLVVHCSAGVGRSGAFIVIDSMIKrihdnGDLDIFNFLAHIRNQRNHLVQEECQYIF
  .. |.....|||||.|.   .   .|..| .  .    | || .|||||||||.|...... |..      ...... |...|.|| . |. . |..|
erlgiqylylpwpDhgvpdllellleflefieealke...g.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

IHDTLAE
... . |
lyefele
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 212-319 2.4e-17 57.5 In-house 187-289 (305) alignment 
Range on Protein: 212-319
Range on HMM: 187-289/305.0
PMMVKQFHFTGWPDHGAPEpgFEFPVLDLImkstACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLD-IFNFLAHIRNQRNHLVQEECQYIF
 | |.....| ||| | |     .  |.|.    ...     |.|||||||.||.|. . |. ....| .| .   . ...  .|.|| . .|.. ||.|
kmsvrhlqwtewpdrgvpp..ckltslell....sairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylf

IHDTLAEYI
||  . .|.
ihrvmlnyf
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 213-364 2.3e-29 96.9 In-house 172-318 (515) alignment 
Range on Protein: 213-364
Range on HMM: 172-318/515.0
MMVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
  | |||||.|||.|.|.      .| || .  |     | ||..|||||||| | .| |||.. ....   .|.|||.  ||..| .||| . || ||.
rtvtqfhfteWPdkGvpkh..tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiy

DTLAEYIA-CNFVIslPIKALKDHVRMMRmpISIQPPVKSKLDLEYEVLYCSC
... |..   | .|  |.  . ||.. .    | .   .||.  |.. | . |
gavledllwrntli..pvihftdhlqdlh..ssgdgrgrskmtkefqtlkslc
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 213-333 8.7e-27 89.1 In-house 178-301 (325) alignment 
Range on Protein: 213-333
Range on HMM: 178-301/325.0
MMVKQFHFTGWPDHGAPE-PGFEFPVLDLIMKSTACVVP---GTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
. ||||.. .|.| | .. |    ..|.|. .   .|     ...|..|||||||||.|.|| . |..... ..  .|||.|. ..|..|  .|.   ||
rsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqy

IFIHDTLAEYI-ACNfvISLPIKALK
|.|...|.|.. . |    .|. ...
iliyealveaymsgn..tdvpvssfe
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 213-321 1.2e-25 85.3 In-house 177-286 (297) alignment 
Range on Protein: 213-321
Range on HMM: 177-286/297.0
MMVKQFHFTGWPDHGAPEPGFEFPVLDLIMKSTACVVP-GTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFI
 .|||..|. |||.  ..      .|.||            |||.|||.||||| | .. |||.. ..... ..|||... ..|..| .||| . || |.
rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv

HDTLAEYIAC
. .. |.. .
yvavlealls
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 213-343 2.1e-24 80.7 In-house 89-217 (440) alignment 
Range on Protein: 213-343
Range on HMM: 89-217/440.0
MMVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTA-CVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFI
  .||.|. ||||.| |.  |  ||| .|          | |||.||||||.||.|  |..||...  . . ..|||.|.  .||.| ..||   || |.
rtlkqyhyqgwpdkgvpk..fagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDTLAEYIACNFVISLPiKALKDHVRMMRMPI
|... | . |  .. |    . ..|  ...| 
heavlegllcgdtlile.dditerveqiqwpn
subfamily_PTPN13_pd Subfamily PTPN13 213-315 4.7e-24 80.1 In-house 166-265 (273) alignment 
Range on Protein: 213-315
Range on HMM: 166-265/273.0
MMVKQFHFTGWPDHGAPEPGFEfpVLDLIMKSTAcVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
  | ...|. ||||| |    |  .| ....    .   .||.|||||||.||||..|.|| ..  |. . ..|. . . ..|.||. .|| . ||||..
revahlnfvkwPdhgvPssaae..llqfvaevrr.lqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvy

DTL
 ..
kai
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 213-322 6.8e-19 62.7 In-house 168-280 (287) alignment 
Range on Protein: 213-322
Range on HMM: 168-280/287.0
MMVKQFHFTGWPDHGAPEP--GFEFPVLDL-IMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYI
 .|||...  |||....    |.   |||       |    ..||||||...|.|||| .. .  ...|  | | .|. . ....|..|. |||   |. 
rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlr

FIHDTLAEYIACN
.. ..|. |   |
llyealvtyyktn
subfamily_PTPN23_pd Subfamily PTPN23 213-315 2.5e-18 60.9 In-house 171-276 (288) alignment 
Range on Protein: 213-315
Range on HMM: 171-276/288.0
MMVKQFHFTGWPDHGAPE-PGFEFPVLDLIMK-STACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIH-DNGDLDIFNFLAHIRNQRNHLVQEECQYI
 .|.  ..| ||..|.|. |.  . .|| . .  .|   .   ||||||||||||.|.| .. . .. .. .|| ||| . . ..|.|| . |||. |. 
ksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk

FIHDTL
|  .  
fsyeav
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 214-318 1.1e-31 105.3 In-house 186-291 (319) alignment 
Range on Protein: 214-318
Range on HMM: 186-291/319.0
MVKQFHFTGWPDHGAPEPGFefPVLDLIMK--STACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFI
 ..|||| ||||.| |. .   ... |. |         .  ..||||||||||.|..||.| ...|....  .|..||.  .|.|||.|||.  || ||
kitqfhflGwpdvGvpdyps..dlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

HDTLAE-Y
. .| | .
ysalleeh
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 214-318 4.4e-31 103.4 In-house 150-255 (284) alignment 
Range on Protein: 214-318
Range on HMM: 150-255/284.0
MVKQFHFTGWPDHGAPEPGFefPVLDLIMK--STACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFI
 ..|||| ||||.| |. .   ... |. |         .  ..||||||||||.|..||.| ...|....  .|..||.  .|.|||.|||. .|| ||
kirqfhflgwpdvgvpdyps..dlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

HDTLAE-Y
. .| | .
ysalleeh
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 214-315 4.1e-29 96.4 In-house 137-236 (239) alignment 
Range on Protein: 214-315
Range on HMM: 137-236/239.0
MVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
 | |.||| |||.| |.  .   || |  | |   .||. | |.||||||||.|||.|||.|... . .  .||||..  ||..| |.||   ||.||| 
yvyqyhftvwpdkgvpq..yatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

TL
..
av
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 214-314 4.8e-29 96.2 In-house 138-236 (239) alignment 
Range on Protein: 214-314
Range on HMM: 138-236/239.0
MVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
 | |.||| |||.| |.  .   || |  | |   .||. | |.||||||||.|||.|||.|... . .  .||||..  ||..| |.||   ||.||| 
yvyqyhftvwpdkgvpq..yatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

T
.
a
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 214-359 1.4e-28 94.7 In-house 174-314 (315) alignment 
Range on Protein: 214-359
Range on HMM: 174-314/315.0
MVKQFHFTGWPDHGAPEPGFefPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
 | ||.||.|||.|...      .| || .  |   . . .|.|||||||||.| .| ||.....|...  .|.|||.  .|..| .||| | .| ||.|
tvtqfqftewPdkGvdkqts..sllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiyd

TLAEYIACNFVIsLPIKALKDHVRMMRmpISIQPPVKSKLDLEYEV
.. |..    .. ...  . ||.. ..   | .   .||.  |.| 
avledllwrntl.ilvihftdhlqdlh..tsvdgsgrskmtkefet
subfamily_PTPN12_pd Subfamily PTPN12 214-321 9.1e-27 88.7 In-house 171-279 (290) alignment 
Range on Protein: 214-321
Range on HMM: 171-279/290.0
MVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRI---HDNGDLDIFNFLAHIRNQRNHLVQEECQYIF
.|.|||.| ||||| |.   . ..|.|| .          |||||||||||| |. |.|| . . .   . . .||.|. ....|.||. ||| . || .
kvyqfhYtaWPDhgvPss..aksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyel

IHDTLAEYIAC
.. ..||..  
vykavaelvqk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 214-322 1e-24 82.1 In-house 176-282 (315) alignment 
Range on Protein: 214-322
Range on HMM: 176-282/315.0
MVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
 | |.|.| ||| | |.  .  |...|| .         |..||||||||||.|.|| .|....... .  .|..||.  .|..| ..||   || ||.|
evvqlhytswpdmgvpk..ytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyd

TLAEYIACN
.| | . | 
alletfvcg
subfamily_PTPN9_pd Subfamily PTPN9 214-319 2.7e-23 77.4 In-house 174-290 (297) alignment 
Range on Protein: 214-319
Range on HMM: 174-290/297.0
MVKQFHFTGWPDHGAPEPGFEF-PVLDLIMKSTACVVP----------GTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLV
 |  | |..|||.| |. . ..  ||. . .  |..|              |.|||||||.||.|.|| .|  ..|... | .|... . ..|.|| . .
kvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsi

QEECQYIFIHDTLAEYI
| . || | . .. || 
qtpeqyefcylavleya
subfamily_PTPN3_pd Subfamily PTPN3 214-316 1.9e-20 67.9 In-house 172-272 (280) alignment 
Range on Protein: 214-316
Range on HMM: 172-272/280.0
MVKQFHFTGWPDHGAPEPGFEFpvLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHD
.. |. .. ||||| |.   .|  |... .  ..    . |.|||||||.||.| .|...  .  |  . .. . . . ..|.||  ||| . || |. .
kilqlqylaWpdhgvPddsadf..lefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCe

TLA
.. 
ail
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 214-322 8.5e-20 65.7 In-house 187-290 (305) alignment 
Range on Protein: 214-322
Range on HMM: 187-290/305.0
MVKQFHFTGWPDHGAPEpgFEFPVLDLIMKSTacvvPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLD-IFNFLAHIRNQRNHLVQEECQYIFIH
 |...|.  ||| | |    .  .|.|. |.     |  ||.|||||||.||.|. .... .....     ..     | .||.|||  .| . ||.|.|
kvthyhwidwpdrgvpa..adlailellekar....pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh

DTLAEYIACN
. . .|.  .
qvilnyfrkk
subfamily_PTPRN_pd Subfamily PTPRN 214-319 9.3e-20 65.5 In-house 188-292 (297) alignment 
Range on Protein: 214-319
Range on HMM: 188-292/297.0
MVKQFHFTGWPDHGAPEPgfEFPVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHD-NGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
 | ||||  ||..|.|      ..|..  |   .    . |.|||||.|.||.|..|.|| ...|.     ..||   | |.|.||..||. . |. |. 
tvtqfhflswpeegvPas..aksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefal

DTLAEYI
 ..|| .
tavaeev
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 214-319 7.9e-19 62.8 In-house 177-277 (307) alignment 
Range on Protein: 214-319
Range on HMM: 177-277/307.0
MVKQFHFTGWPDHGAPEpgFEFPVLDLImkstACVVPGTGPLVVHCSAGVGRSGAFIVIDSMI-KRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
 .... .. |||.|.|.   ..  ..|.      |   | |.||||||||||||. . |  .  | |      |. ...  .|.||.. .|.| ||...|
tiqhlqwenwpdrgvpq..inltainll....eavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh

DTLAEYI
  | || 
rvlleyf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 214-313 6.5e-07 23.8 In-house 159-253 (290) alignment 
Range on Protein: 214-313
Range on HMM: 159-253/290.0
MVKQFHFTGWPDHGAPEPGFEfpVLDLIMKstacVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIH-DNGDLDIFNFLAHIRNQRNHLVQEECQYIFIH
 |.   . || .  ..|      .|.||.|    |   . | .|||  |. || |.  |.     |   .|.. . . |  .|.||....... .. |. 
tvtHsllkgWnklnvqedtkt..llsliqk....vkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd

D
 
a
PTPc_DSPc_SM00012 215-317 6.2e-31 102.1 In-house 2-105 (105) alignment 
Range on Protein: 215-317
Range on HMM: 2-105/105.0
VKQFHFTGWPDHGAPEPGfeFPVLDLIMKSTACVVPG--TGPLVVHCSAGVGRSGAFIVIDSMIKRIHDN-GDLDIFNFLAHIRNQRNHLVQEECQYIFI
||..|.|||||||.||..   ..|.|. .   .      ..|.||||||||||.| |...| ........ . .|||... ..|.||...||.| ||.|.
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

HDTLAE
.. |.|
yralle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 215-320 5.5e-22 73.0 In-house 154-265 (270) alignment 
Range on Protein: 215-320
Range on HMM: 154-265/270.0
VKQFHFTGWPDHGAPEPGF----EFPVLDLIMKSTACVV--PGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQY
.  |... |||||.|.          .| .. .  .       ..||.|||||||||.| .|..| ... .. .. .|. . ....|..|  |||   ||
lvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqy

IFIHDTLAEYIA
 |.. ...||. 
eflykavveyae
subfamily_PTPN14_pd Subfamily PTPN14 215-319 9.1e-22 72.4 In-house 185-296 (300) alignment 
Range on Protein: 215-319
Range on HMM: 185-296/300.0
VKQFHFTGWPDHGAPEPGFEFP----VLD-LIMKSTACV--VPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQ
|  . .| ||||| ||   .|      .. .  |..  |       |..|||||||||.|  |. | .|. .. | ..|| . ||..|.|| .|||  .|
vwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaq

YIFIHDTLAEYI
| |....| .|.
YkfvYkvlikyl
subfamily_ptpA1_pd Subfamily ptpA1 215-279 5.9e-09 30.1 In-house 188-256 (418) alignment 
Range on Protein: 215-279
Range on HMM: 188-256/418.0
VKQFHFTGWPDHGAPEPGFEFP-VLDLIMKSTACVVPGT---GPLVVHCSAGVGRSGAFIVIDSMIKRI
. |... |||||  |.    |  .|  | .    ..| .    |..|||||||||.|.|     |.|..
itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 215-330 1.1e-08 29.1 In-house 173-290 (303) alignment 
Range on Protein: 215-330
Range on HMM: 173-290/303.0
VKQFHFTGWPDHGAPEPGFEFPVLDL-IMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDN-GDLDIFNFLAHIRNQRNHLVQEECQYIFIH
..  |.  ||    |  |    | ..  ..|       . | |    .|.||.|.| ....    .|..   ||. . |  .|| | | ||. .|. ...
lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvy

DTLAEYIACNFVISLPIK
  |||..  | .. | | 
tllaehvldngicklaip
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 216-320 2.9e-12 40.9 In-house 179-277 (312) alignment 
Range on Protein: 216-320
Range on HMM: 179-277/312.0
KQFHFTGWPDHGAPEpgfefpVLDLIMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTL
... .. ||||| |.        |  ..  ..|     |.. ||||||||.|....|.|||  .      .. . .  .|..|   |.   ||..   ..
nhyqwaswpdhgmpd......scdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcv

AEYIA
 |.. 
lefly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 241-314 8e-12 39.6 In-house 217-290 (297) alignment 
Range on Protein: 241-314
Range on HMM: 217-290/297.0
IMKSTACVVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDT
 ..|     |   .|.|||||||||||  .  | .....  .   |.  .| ..|.||  |||   |. ...| 
qleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_eak_pd Subfamily eak 243-320 2e-09 31.3 In-house 228-306 (332) alignment 
Range on Protein: 243-320
Range on HMM: 228-306/332.0
KSTACVVPGTGPlVVHCSAGVGRSGAFIVIDSMIKRIHDN--GDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
|      |   | .. .. |  |.|.|.||| .|. | ..      . ...  ....|.| |  . |. ||.. . .|. 
kkyihtppsfap.iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 248-319 6.3e-26 86.0 In-house 188-259 (267) alignment 
Range on Protein: 248-319
Range on HMM: 188-259/267.0
VVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYI
.  |  ||||.||.||||||.|.||||...|.  .| .|||.|| .||.||  ||.   .||.||..|||| 
lengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 248-320 2.7e-10 34.1 In-house 214-286 (302) alignment 
Range on Protein: 248-320
Range on HMM: 214-286/302.0
VVPGTGPLVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
 .... ..|.    |.|| |||..    ....... .  | . .. ||.|| . |.  .||.... .|. || 
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik
subfamily_CG42327_pd Subfamily CG42327 252-320 5.1e-14 46.7 In-house 247-316 (319) alignment 
Range on Protein: 252-320
Range on HMM: 247-316/319.0
TGPLVVHCSAGVGRSGAFIVIDSMIKRIHDN-GDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEYIA
 |||||||| ||||.|  |  |  |... ..   .|| . . ..|..| . |..  || ||. .| || .
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 255-318 1.2e-16 54.8 In-house 1-64 (69) alignment 
Range on Protein: 255-318
Range on HMM: 1-64/69.0
LVVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEY
.|||||.| ||.|.|| |   . ||  .  .|||| . ..|  |  .| .| .||||||.|.| 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 256-318 9.6e-16 51.9 In-house 1-63 (69) alignment 
Range on Protein: 256-318
Range on HMM: 1-63/69.0
VVHCSAGVGRSGAFIVIDSMIKRIHDNGDLDIFNFLAHIRNQRNHLVQEECQYIFIHDTLAEY
|||||.| ||.|.|| |   . ||  .  .|||| . ..|  |  .| .| .|.||||.|.| 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
0045098 (Phosphotyrosine protein) phosphatases II 386-612 8.9e-56 184.6 In-house 31-251 (278) alignment 
Range on Protein: 386-612
Range on HMM: 31-251/278.0
LSGVPLRRVPRICVIDSSRVRlyprpgeegsDYINASYIDGFtrREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAH
|..... | . |  .|.|||.          ||||||||||.  . .|||||.||.||. |.|||.|......|||| ...|...  .. | |  ...  
lgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggslt

FGDYEVTMESETARGDFIIRDLKLIST---KDPSVIRQIRHFHFLHWPEHGQPWSG--QTVLQLVSKVEEWESEVEKNS---------HqfdiiGPIVVH
.||..||..||.  .|...|.|... .   .     | ..|.|.|.||.|| | .   . .|.|.  ..|. ... .           .     ||..||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg.....gpvlVH

CNNGIGRTGVYCALHALWQQItqEKLVSVYQTAWLQGHQRP
|. |.||||...|.. . ...  |. |.....      |||
CsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRp
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 386-463 6.7e-11 36.2 In-house 32-107 (332) alignment 
Range on Protein: 386-463
Range on HMM: 32-107/332.0
LSGVPLRRVPRICVIDSSRVRLYPRPGEEgsDYINASYIDGFTRREAFIATQHPLQSTT-MDYWRMIWQENCrSIVMLL
|  . . |.|.. ..| ||| | |. |..  |. |||..||.... |.| .| |..  |   .|||. . .  |.....
lnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkp.smilvf
0045450 (Phosphotyrosine protein) phosphatases II 387-612 1.1e-62 207.9 In-house 54-284 (307) alignment 
Range on Protein: 387-612
Range on HMM: 54-284/307.0
SGVPLRRVPRICVIDSSRVRLYPRPGE-EGSDYINASYI--------DGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYL
   ...| . |   |..||.| . .|. |.||||||||.        ||. .  .|||||.||..|  |.|||.|..... |||| ...| ..   . | 
enkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

PAVHDTAHFGDYEVTMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIG
|   ..  .|.. ||. ||.  .....| |..  ..  .  |...|||...||.|| | | ...|... .|... .|  |.       ||..|||. |.|
Pdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkg.......gpvlVHCsaGvg

RTGVYCALHALWQQITQEKL---VSVYQTAWLQGHQRP
|||...|.  ...|. .|.    |.....  |   |||
RtGtfiaaylmlrqlekegtlldvdlleavkllreqRp
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 388-612 6.8e-46 151.4 In-house 46-263 (290) alignment 
Range on Protein: 388-612
Range on HMM: 46-263/290.0
GVPLRRVPRICVIDSSRVRLYPRPGEEG--SDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVhDTAH
  .|.|  .| | |  |. | | .|..    .||||.||.|.  ....|||| |...| .|.|..||||..  ||||....| .|..   | |.  ||..
nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka

FGDYEVTMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveKNSHqfdiiGPIVVHCNNGIGRTGVYCAL
.| ..... .|..  ..|.| |.. ...     ... ....  |...|.    ||.|........ .    |.       ..||||| ...||..|.||.
ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqr...krgn.....tsivvHCSdtvgrsavfcaa

HALWQQITQEKLVSVYQTAWLQGHQRP
.   ..  .|  . |.|    |  |.|
attinkcktegvidvfqvlksqRiqkp
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 388-437 3.5e-06 21.1 In-house 48-94 (95) alignment 
Range on Protein: 388-437
Range on HMM: 48-94/95.0
GVPLRRVPRICVIDSSRVRLYPRpgeEGSDYINASYIDGFTRREAFIATQ
 .|  |.  |   |..|| |  .     |||||| ..||..|....||.|
nipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaq
0040438 (Phosphotyrosine protein) phosphatases II 389-612 2.3e-66 219.6 In-house 44-256 (317) alignment 
Range on Protein: 389-612
Range on HMM: 44-256/317.0
VPLRRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGD
 ...| | |   |.|||.| | .| ..||||||||.||. .. .|||||.||..|. |.|||.|......|||| ...| ..  .  | |   .| ..||
kdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygd

YEVTMESETARGDFIIRDLKLISTkDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESevEKNshqfdiiGPIVVHCNNGIGRTGVYCALHAL
. ||. ||.  .....| |..  . . |  |...|||...||.|| | | ...|.....|.|. .  ...       ||..|||..|.||||...|.  .
ftvtllseeelagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpg.......gpvlVHCsaGvgRtGtfiaaylm

WQQITQEKLVSVYQTAWLQGHQRP
..|. .|. |.|...     .|||
leqlekeggvdveeavkelreqRp
0043336 (Phosphotyrosine protein) phosphatases II 389-612 1e-62 207.5 In-house 46-257 (278) alignment 
Range on Protein: 389-612
Range on HMM: 46-257/278.0
VPLRRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPavHDTAHFGD
....| . |   |.|||.| . .|...||||||||.||. . ..|||||.||..|. |.|||.|......|||| ...|...  .  | |   ..  .||
kdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygd

YEVTMESETARGDFIIRDLKLISTKDPSViRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveK-NshqfdiiGPIVVHCNNGIGRTGVYCALHA
. ||. .|.  .|...|.|..  ..|. . |...|.|.|.||.|| | | ...|... .| |. .   . |       ||..|||..|.||||...||  
ftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavreale...dsn.......gpvlVHCsaGvgRTGtfialyl

LWQQITQEKLVSVYQTAWLQGHQRP
|..|.  |. |.....     .|||
lleqlekeggvdleeavkelreqRp
0040439 (Phosphotyrosine protein) phosphatases II 389-612 2e-59 196.5 In-house 12-226 (249) alignment 
Range on Protein: 389-612
Range on HMM: 12-226/249.0
VPLRRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGD
....| | |   |.|||.| . || ..|||||||||||. .  .|||||.||..|. |.|||.|......|||| |..| ..  .  | |   ..  .||
kdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygd

YEVTMESETARGDFIIRDLKLISTKDPSViRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIGRTGVYCALHAL
. ||. |..  .|...| |.|  ..|... |...|.....||.|| | | ...|... .|... .| .|.       ||..|||..|.||||...|.  .
ftvtllsvevkddytvrtleltnlydges.rtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkg.......gpvlVHCsaGvgRtGtfiaaylm

WQQITQEKLVSVYQTAWLQGHQRP
..|.  |. |.....  |  .|||
leqlekelgvdleeavkllrsqRp
0042113 (Phosphotyrosine protein) phosphatases II 389-612 6.4e-58 191.4 In-house 10-223 (245) alignment 
Range on Protein: 389-612
Range on HMM: 10-223/245.0
VPLRRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGD
....| . |   |..||.| | .|...||||||||.||. . . |||||.||..|. |.|||.|......|||| .| | ..  .. | |  ...  .||
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygd

YEVTMESETARGDFIIRDLKLISTkDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEveknS-HqfdiiGPIVVHCNNGIGRTGVYCALHA
. ||. ||.  .|...| |..  .   .  |...|.|.|.||.|| |.. ...|.... |... .|    . .     ||..|||. |.||||...|.  
ftvtllseehlddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalae....dsn.....gpvlVHCsaGvgRtGtfiaayl

LWQQITQEKLVSVYQTAWLQGHQRP
...|.  |. ||....      |||
mleqlekelgvsleeavkelrsqRp
0037934 (Phosphotyrosine protein) phosphatases II 389-612 9.3e-52 171.3 In-house 11-221 (243) alignment 
Range on Protein: 389-612
Range on HMM: 11-221/243.0
VPLRRVPRICVIDSSRVRLyprpgeEGSDYINASYIDGFTRreaFIATQHPLQSTTMD----YWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPavhDTA
.. .|.. |   | |||.|      ||||||||..|... |   .||||.||..|. |    .|||.|......|||| ...| ..   . | |   .. 
lsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev

HFGDYEVTMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESE-----VEKNShqfdiiGPIVVHCNNGIGRT
..||..||. ||.  .|...| |.|  .. . . |...|.|.| ||.|| | | . .|.....| |. .|     .....      ||..|||  |.|||
tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg......gpvlVHCsaGvgRt

GVYCALHALWQQItqeKlVSVYQTAWLQGHQRP
|...|.  . ...   . |.....  |   |||
Gtliaaylmllll...g.vdleeavkllreqRp
0046845 (Phosphotyrosine protein) phosphatases II 390-612 3.6e-69 228.6 In-house 30-254 (284) alignment 
Range on Protein: 390-612
Range on HMM: 30-254/284.0
PLRRVPRICVIDSSRVRLYPRPGE-EGSDYINASYIDGF-----TRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDT
 . | . | . |.|||.| . .|. |.||||||||.||.      .. .|||||.||..|. |.|||.|..|.| |||| .. | ..  .. | |  ...
sknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegev

AHFGDYEVTMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEveknshqFDIIGPIVVHCNNGIGRTGVYC
 ..||. ||. ||. ..|...| |.|  .. ..  |...|||...||.|| | | . .|... .|.|. ..       ..  ||||||| .|.||||...
ltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.......lpgggpivVHCsaGvgRtGtfi

ALHALWQQITQEK---LVSVYQTAWLQGHQRP
||. |..|. .|.    |.|...      |||
aldllleqlekeglllgvdvleavkrlreqRp
0050432 (Phosphotyrosine protein) phosphatases II 390-612 5.9e-68 224.8 In-house 70-279 (308) alignment 
Range on Protein: 390-612
Range on HMM: 70-279/308.0
PLRRVPRICVIDSSRVRLyprpgEEGSDYINASYIDGF--TRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV--HDTAH
.. | . |   |.|||.|     .||||||||||.||.   .. .|||||.||..|. |.|||.|..|.| |||| .. | ..  .. | |    ... .
dkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsle

FGDYEVTMESETARGDFIIRDLKLISTKDPSViRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWEseveKNshqfdiiGPIVVHCNNGIGRTGVYCAL
.|.. ||. ||. ..|...| |.|  ..|. . |...|||...||.|| | | . .|... .|...     ..       |||||||..|.||||...||
ygkftvtllseevlddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrksl....pg.......gpivVHCsaGvGRtGtfial

HALWQQITQEKLVSVYQTAWLQGHQRP
  |..|. .|. |.|...     .|||
dllleqlekeggvdvfeavkklReqRp
0047943 (Phosphotyrosine protein) phosphatases II 390-612 5.1e-65 215.0 In-house 40-252 (273) alignment 
Range on Protein: 390-612
Range on HMM: 40-252/273.0
PLRRVPRICVIDSSRVRLyprpGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD--TAHFG
 . | . |   |.|||.|    |..|||||||||.||. .  .|||||.||..|. |.|||.|..|.| |||| .. | ..  .. | |   .  .  .|
dknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltyg

DYEVTMESETARGDFIIRDLKLISTKDPSvIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIGRTGVYCALHA
.. ||. ||. ..|...| |.| .....   |...|||...||.|| | | . .|... .|... ... .|       ||.||||..|.||||...||. 
kftvtllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsn.......gpvvVHCsaGvgRtgtfialdl

LWQQITQEKLVSVYQTAWLQGHQRP
|..|.  |. |.|...  |   |||
lldqlekeggvdvleavkllrsqRp
0036941 (Phosphotyrosine protein) phosphatases II 390-612 1.8e-63 210.0 In-house 41-257 (297) alignment 
Range on Protein: 390-612
Range on HMM: 41-257/297.0
PLRRVPRICVIDSSRVRLyprpGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFGD
.. | . |   |..||.|    ..||||||||||.||. .  .|||||.||..|. |.|||.|..|...|||| .. |...  ...| |    ..  .||
eknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygd

YEVTMESETA--RGDFIIRDLKLISTKDPsVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIGRTGVYCALH
. ||. |..    .|...| |..  |...   |...|||...||.|| | | ...|... .|... ..  ..       ||..|||..|.||.|...|. 
ftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg.......gpvlVHCsaGvgRsgtfiaad

ALWQQIT---QEKLVSVYQTAWLQGHQRP
 ..||.     |. |.....     .|||
lmlqqledklkeggvdileavkklReqRp
0039614 (Phosphotyrosine protein) phosphatases II 390-612 1e-62 207.6 In-house 58-269 (297) alignment 
Range on Protein: 390-612
Range on HMM: 58-269/297.0
PLRRVPRICVIDSSRVRLYPRPGE-EGSDYINASYIDGFTR-REAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKdVFPSYLPAVHDtaHFG
...| . |   |.|||.| | .|  ..||||||||.||. .   .|||||.||..|. |.|||.|......|||| ...| ..  ...| |   .   .|
dknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tyg

DYEVTMESETARGDFIIRDLKLIStKDPSviRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIGRTGVYCALHA
|. ||. ... ......| |..   ...|  |...||....||.|| | | ...|... .|.|. .| .|.       ||..|||..|.||||...|.  
dftvtllkvehldgytvrtlevtn.nges..rtvthfqytgwpdhgvppslellleflelvrealaelpkg.......gpvlVHCsaGvgRtGtfiaayl

LWQQITQEKLVSVYQTAWLQGHQRP
...|.  |. |.|...      |||
mleqlekeggvdvleavkelreqRp
0051299 (Phosphotyrosine protein) phosphatases II 391-612 1.2e-68 227.0 In-house 52-266 (288) alignment 
Range on Protein: 391-612
Range on HMM: 52-266/288.0
LRRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGDYE
  | . |   |.|||.| . .|.|||||||||||||. .  .|||||.||..|. |.|||.|..|.| |||| .. |...  .. | |  ...  .||. 
knRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygdit

VTMESETARGDFIIRDLKLISTK---DPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveknshqfDIIGPIVVHCNNGIGRTGVYCALHA
||. ||.  .|...| |..  ..    ..  |...|||...||.|| | | . .|... .| .. .         .  ||.||||..|.||||...||  
vtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.........sgggpvvVHCsaGvgRtgtfialdl

LWQQITQEKLVSVYQTAWLQGHQRP
|..|. .|. |.|...     .|||
lleqlekeggvdvleavkrlreqRp
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 391-586 4.6e-16 53.4 In-house 46-230 (312) alignment 
Range on Protein: 391-586
Range on HMM: 46-230/312.0
LRRVPRICVIDSSRVRLyprPGEEgSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYE
| | | | . |  |  |    |.|   || | ..   |. | |..|| ||..|.  .|..     . ||..| .  |   .    |.  .    .. |. 
lnrypniqcwdrgrftl...agde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

VTMESETA------RGDFII-RDLKLIsTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewesevEKNSHqfdiigPIVVHCNNGIGRTGVYC
|  |. |         | |  | ||..  |      .. |. .  ||.|| | | .| |.|.| |        |. .      |.. ||  |.||||  .
vyteycteieiggkskdkithrvlkvv.vkatgqesklnhyqwaswpdhgmpdscdtalrllsav.......kkdkk......pviahcsagvgrtgtla

ALH
 . 
lie
subfamily_PTPRD_pd Subfamily PTPRD 392-612 3.4e-86 285.1 In-house 52-261 (564) alignment 
Range on Protein: 392-612
Range on HMM: 52-261/564.0
RRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHdTAHFGDYEV
.|.  |.  |.|||.| . .|.|||||||||.|||...|.|.||||.||..|..|.|||.|..|...|||| . .|..|. . .| |. . |...|...|
NRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltV

TMESETARGDFIIRDLKLiSTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveknshqfDIIGPIVVHCNNGIGRTGVYCALHALWQQ
|.|.|.   |..||..|| ..|. |  |..|.||| .||.||.|.|....|.|..||.....         .  |||||||..|.||||......|....
tleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne.........pdagPivVhCSaGVGRTGtfividamler

ITQEKLVSVYQTAWLQGHQRP
|..||.| .||. ..  .||.
ikeektvDiyqyvkalrkqRn
Y_phosphatase Protein-tyrosine phosphatase 392-604 2e-57 189.7 Pfam-A 5-209 (235) alignment 
Range on Protein: 392-604
Range on HMM: 5-209/235.0
RRVPRICVIDSSRVRLyprPGEEG-SDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLP-AVHDTAHFGDY
.| . | ..|..||.|    |.|| ||||||.|..|... ..|||||.||.||  |.|||.|||....|||| |..| ..  .. | | . ... ..||.
nRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

EVTME-SET-ARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWEseveknshqFDIIGPIVVHCNNGIGRTGVYCALHA
.|... .|. .  ....|.|.| ..|..|  |.....|. .||.|| | | . .|.|. |||...          .  ||.|||| .|.||||...|| .
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgtfvaldi

LWQQITQEKLVSVYQTA
|..|...|. |.|.|. 
lleqleaeeevdvlqiv
Y_phosphatase Protein-tyrosine phosphatase 392-604 2e-57 189.7 In-house 5-209 (235) alignment 
Range on Protein: 392-604
Range on HMM: 5-209/235.0
RRVPRICVIDSSRVRLyprPGEEG-SDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLP-AVHDTAHFGDY
.| . | ..|..||.|    |.|| ||||||.|..|... ..|||||.||.||  |.|||.|||....|||| |..| ..  .. | | . ... ..||.
nRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

EVTME-SET-ARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWEseveknshqFDIIGPIVVHCNNGIGRTGVYCALHA
.|... .|. .  ....|.|.| ..|..|  |.....|. .||.|| | | . .|.|. |||...          .  ||.|||| .|.||||...|| .
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgtfvaldi

LWQQITQEKLVSVYQTA
|..|...|. |.|.|. 
lleqleaeeevdvlqiv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 392-603 4.2e-55 182.0 In-house 50-254 (305) alignment 
Range on Protein: 392-603
Range on HMM: 50-254/305.0
RRVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDT-AHFGDYE
 |.  | . | .|..| ... .. ||||||||.||. |....|..| ||..|  |.||.|..|  ..||||   .| .||    | |  .    .||...
nrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefs

VTMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEewesevekNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQ
|...||..  |.|.|.||.   .. .  |.. ....  ||.|| | .  ..|.|. .|.        .... |   |..|||..|.|||||..|..   .
velksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvq........kdqkkdkgvpllVhCsagvgRtGvfiavdiale

QITQEKLVSVYQT
.. .|. | |.. 
rlkkEevvdvfev
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 392-611 3.6e-43 142.6 In-house 51-257 (287) alignment 
Range on Protein: 392-611
Range on HMM: 51-257/287.0
RRVPRICVIDSSRVRLYprpgEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDtAHFGDYEV
 |. .| | |  || |     .|  |||||..|||.  . |||... |. .|  ..|..|...|   ||||  ||| |..|   | |  .    .|.|..
nRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyni

TMESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEwesEVEKNSHqfdiiGPIVVHCNNGIGRTGVYCALHALWQQ
.. .|.   ..|.|.|... ..  .  .|.. ...  |...|.  . ||.| .. .      .  |...     ..||||| ...||....||     ..
ellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk...tqrkrgn.....tsivvhCsdtvGrsamfcaaattink

ITQEKLVSVYQTAWLQGHQR
  .|  . |.|    |  |.
ckteGviDvfqvlksqriqk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 392-604 1.6e-36 120.7 In-house 37-238 (283) alignment 
Range on Protein: 392-604
Range on HMM: 37-238/283.0
RRVPRICVIDSSRVRLYPRPGeegsDYINASYID---GFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGD
 |   | . |  ||.| . .     |||||..|       . . .|..| ||. | .|.|.|...|.  .||||   .|  .     | |  . .  .|.
nrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk.rGsedyGe

YEVTMESETARGDFIIRDLKLISTK-DPSVIRqIRHFHFLHWPEHGQpwsgQTVLQLVSKVEEWESEVEKNSHqfdiiGPIVVHCNNGIGRTGVYCALHA
. ||.. ||.   |||. | |       | .  . |. .  | | |.    |...  . |..   |   .. .     ||||||| .|||||.|..|. |
ftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleyge....qaiinslvkfnkvislqteskk.....gPivvhCstgiGrtavfiaasa

LWQQITQEKLVSVYQTA
  ...  | .| |... 
svkdaltesvvdvfavv
0049772 (Phosphotyrosine protein) phosphatases II 392-600 4.8e-34 113.9 In-house 50-249 (314) alignment 
Range on Protein: 392-600
Range on HMM: 50-249/314.0
RRVPRICVIDsSRVRLyPRPGEEGSDYINASYIDGFtrrEAFIATQHPLQSTTMDY----------WRMI--WQENCRSIVM------------------
 | ..|.  | .||.| |. . .|||||||||.|||    .|||||.||. |  |.          |||.  .. |.| |||                  
nryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlg

---LLSEKEWDkdvfpsylpA---------VHdtahfgdyevtmesetargdfiirdlkLISTKDPSVIRQIRHFHFLHWPEHGQPwSGQTVLQLVSKVE
   ||.  .           .          .                            . . .. . |.. ... ...| ...| . . .....  .|
Ktpllildgng.........neptaadlellk...........................eelydpelferlgikylripvpDgsap.lledfdeflefie

EWeseveknshqfDIIGPIVVHCNNGIGRTG--VYCALHALWQQITQEKLVSV
|.           |  ||..|||. |.||||  | .|.  . .... |. .. 
ea...........dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealed
subfamily_PTPRN_pd Subfamily PTPRN 392-593 8.8e-34 111.5 In-house 60-252 (297) alignment 
Range on Protein: 392-593
Range on HMM: 60-252/297.0
RRVPRICVIDSSRVRLYPRPGEEGSDYINASYI-DGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHdTAHFGDYE
 |.  .   | |||.|  .  .| ||||||| | |   |. |.|||| || ||  |.|.|.|.. .  ||.| . .| .      | |    .. .. ||
nrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG.sevyhiye

VTMESETAR-GDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEeweseveKnSHQFdIIGPIVVHCNNGIGRTGVYCALHALW
| . ||     |...| . |   .  |  | .  |||| |||.| | | ...|..  ||.       | |..     |||||| .| ||||||...  . 
vhlvsehiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPasaksllefrrkvn.......k.syrG.rscpivvhcsdGaGrtGvyilidlvl

QQIT
....
nrll
0041856 (Phosphotyrosine protein) phosphatases II 392-611 1.6e-31 104.7 In-house 5-150 (182) alignment 
Range on Protein: 392-611
Range on HMM: 5-150/182.0
RRVPRICVIDSSRvrlyprpgeeGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVfpsylpavhdtahfgdyev
.|.. |  .| ||          ..|||||....|  .   |||||.||.||. |..||........||.| .|  | ...                   
nrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpell...................

tmesetargdfiirdlklistkdpsvIRQIRHFHFLHWPEHGQPWsGQTVLQLVSKVEEweseveknshqfdIIGPIVVHCNNGIGRTGVYCALHALWQQ
                           |.. ....| || || |   ...|... .|.|               ||..|||. |.||||...|.  ....
..........................erlgiqylylpwpDhgvpd.ldelldfieevle.............eggpvlVHCsaGvgRtgtlvaaylmkkl

itqeKlVSVYQTAWLQGHQR
    . ||....  |   .|
....g.vsleeavklvrsrR
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 393-603 1.9e-59 196.3 In-house 61-261 (298) alignment 
Range on Protein: 393-603
Range on HMM: 61-261/298.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHdTAHFGDYEVT
| . |  .|||||.|    ..| |||||||.......|.||||||.||..|. |.|||...|.  .|||| . .| ||  .. | | .. ....|. .|.
RyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdeg.ketygeitvs

MESETARGDFIIRDLKLISTKDPsVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiigPIVVHCNNGIGRTGVYCALHALWQQI
. |.   .|.|.| ||. ..|     |..|..|| .||..| |   ..||.|..||. ....  ..        |..|.| .|.||.| ..|.... ...
llskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnk........pvivqCsaGvgRsGtfiaidsvlerv

TQEKLVSVYQT
 .|. | |.|.
kkeqvvDvfqv
DSPc_SM00195 393-604 2.5e-59 196.1 In-house 31-234 (263) alignment 
Range on Protein: 393-604
Range on HMM: 31-234/263.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFGDYEV
|   | ..|..||.| .....||||||||.||.| ......||||.||.||  |.|||.|.|... |||| .|.| .|    .| |   ...  ||...|
RyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisv

TMESETARG-DFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVeknshqfdiIGPIVVHCNNGIGRTGVYCALHALWQ
.. ... .  ..|.|.|.|  ... .  |.......  ||.|| | | . ||.|...|....|.           ||||||| .|.||||...... ...
klvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.........sgpivVhCsaGvgRtgtfvtidiils

QITQEKLVSVYQTA
....|| |.. .. 
kleeekkvdifeiv
PTPc_SM00194 393-604 2.5e-59 196.1 In-house 31-234 (263) alignment 
Range on Protein: 393-604
Range on HMM: 31-234/263.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFGDYEV
|   | ..|..||.| .....||||||||.||.| ......||||.||.||  |.|||.|.|... |||| .|.| .|    .| |   ...  ||...|
RyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisv

TMESETARG-DFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVeknshqfdiIGPIVVHCNNGIGRTGVYCALHALWQ
.. ... .  ..|.|.|.|  ... .  |.......  ||.|| | | . ||.|...|....|.           ||||||| .|.||||...... ...
klvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.........sgpivVhCsaGvgRtgtfvtidiils

QITQEKLVSVYQTA
....|| |.. .. 
kleeekkvdifeiv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 393-612 9.2e-59 194.1 In-house 53-263 (319) alignment 
Range on Protein: 393-612
Range on HMM: 53-263/319.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKdVFPSYLPAVHDTAHFGDYEVT
| . |  .| .|| | . .| |||||||||.|||. .||.||||| ||. |. |.|||.|.|..  .|||   .|  | |. . ..  ..  ..| . ||
ryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklk.vklkkywpeenfeeyGrlivt

MESETARGDFIIRDLKLiSTKDPSV-IRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeeweseveKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQQ
.|.|    |.|||.|||  .|   |  |.. ||....||.|. | .....|.|. ..        ..|..    ||||||| .|.|||| ...|.|  ..
leeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkri........rksrektqsgPivvhCsaGvGRtGtfivldamler

ITQEKLVSVYQTAWLQGHQRP
. .| .. |..|.     ||.
vkeegvlDvfstvsrlRtqRn
subfamily_PTPRB_pd Subfamily PTPRB 393-603 8.9e-56 184.1 In-house 56-256 (293) alignment 
Range on Protein: 393-603
Range on HMM: 56-256/293.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVT
|  .|   | |||.| .  .|.|||||||.||.|.. .  ||||| || .|. |.|||.|..... ||||    |  |     | || ...  .|| .||
rytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvt

MESETARGDFIIRDLKLIStkdPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQI
. .|.   |..||.||.      . .|..|..||. ||.|| | . .|.|..| .|.|. .. ...       .||||||  |.||||.. ||. | |.|
lvaeeeledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektask.......rPivvhCsaGvGRtGtfialdrllqai

TQEKLVSVYQT
..| .| .. .
eeedyvdifgi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 393-605 1.8e-55 183.5 In-house 66-264 (319) alignment 
Range on Protein: 393-605
Range on HMM: 66-264/319.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLsekewdKDVFPSYLPAVHDTaHFGDYEVT
|. .|   | ..|.| .  |||.|||||||...|. |.. .||.| ||. |  |.|||||. || .||.|       ||    | |   .  . . ..| 
riinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvk

MESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveKNSHQFdiigPIVVHCNNGIGRTGVYCALHALWQQI
..| .   ....||..|        ||.|. |||| ||..|.| ..  ...|| ||.  .|   |. |.     .|||||  |.|||||| .|..| ...
vdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts...kenhra....nivvhcsaGvGrtGvyivldvlldrm

TQEKLVSVYQTAW
 .|| | ||..  
keekqvdvynfvr
subfamily_PTPRK_pd Subfamily PTPRK 393-603 3.7e-55 181.9 In-house 48-248 (314) alignment 
Range on Protein: 393-603
Range on HMM: 48-248/314.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPavHDTAHFGDYEVT
|.  |   | |||.| .  |.  ||||||..||...| .|||.||.|||.|. |.||....||| |||||   .|  .     | |   || ..|| .|.
rsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP..edtevygdikve

MESETARGDFIIRDLKLIS-TKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEveknshqfdIIGPIVVHCNNGIGRTGVYCALHALWQQ
. . ..  ....| ...   ..  . ||..|.|.|| ||.|. | | ...|.|| .|.... |           |.||||| .| ||||...|.. . . 
lvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.........eaGrivvhCsaGaGrtGtfiaidivldm

ITQEKLVSVYQT
| .|..| |...
ieregvvdvfna
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 393-605 7e-55 181.5 In-house 30-228 (284) alignment 
Range on Protein: 393-605
Range on HMM: 30-228/284.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLsekewdKDVFPSYLPAVHDTaHFGDYEVT
|. .|   | ..|.| .  |||.|||||||.| |. |.. .|||| ||. |  |.|||||. || .||.|       ||    | |   .  . . ..| 
righilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerfkvk

MESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveKNSHQFdiigPIVVHCNNGIGRTGVYCALHALWQQI
..| .   ....||..|        ||.|| |||| ||..|.| ..  ...|| ||.  .|   |. |.     .|||||  |.|||||| .|..| ...
vdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhlts...kenhra....nivvhcsagvgrtgvyivldvlldrm

TQEKLVSVYQTAW
 .|| | ||..  
keekqvdvynfvr
subfamily_Ptp69D_pd Subfamily Ptp69D 393-611 2.1e-52 173.2 In-house 53-265 (307) alignment 
Range on Protein: 393-611
Range on HMM: 53-265/307.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVhDTAHFGDYEVT
| . |   |. ||.| . .|.| |||||||.| |.  .. ||| | |...|  |.||||.. .   ||||  ..|....  . | |   |. ..||  |.
RyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvk

MESETARGDFIIRDLKLISTKDPS----VIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVeknshqfdiIGPIVVHCNNGIGRTGVYCALHAL
. ||   .|.|||.|..  .|. |      |..  .|.. |..   | . ...|.|...|.| ..            .||||||..| ||.|.. ||  |
lvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.........rsPivvhCsaGvgrsgifvaldsl

WQQITQEKLVSVYQTAWLQGHQR
.||. .|. |....|     .||
lqqlkaedkvdifetvkdLrsqR
subfamily_PTPRA_pd Subfamily PTPRA 393-611 1.1e-50 167.4 In-house 63-274 (330) alignment 
Range on Protein: 393-611
Range on HMM: 63-274/330.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGDYEVT
||..|   | ||| | .. |.| |||||||.|||. ... |||.| |.. |  |.|||||. .  .||||   || ...    | |  . .  .|.  |.
rvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd.eGlvtyGnirve

MESETARGDFIIRDLKLISTKDP---SVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveknshQfdIIGPIVVHCNNGIGRTGVYCALHALW
.| ||   |. .|.. .    |       |..| |||  ||. | |  .. .|.|. ||.. .        |    |||||||  |.|||| ...| |. 
vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq.......q..sagpivvhcsaGvGrtGtfivldavl

QQITQEKLVSVYQTAWLQGHQR
...  |..| |...      ||
ervkaerkvdvfefvkrlrlqr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 393-603 1.6e-46 153.7 In-house 52-250 (288) alignment 
Range on Protein: 393-603
Range on HMM: 52-250/288.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVT
| . |  .|  ||.|   . |.|.||||||||||  .....|||| ||..|  |.|.......   |||| .  | .|     | |. ..  ..|. .||
RyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvt

MESETARGDFIIRDLKLIstKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVeknshqfdiIGPIVVHCNNGIGRTGVYCALHALWQQI
. ..   .||. | | |   |.    ..| ....| ||.|| | | . .|.|...|.  ...           |||.||| .|.||||.. ||.|| ...
lveskeledfvlrkllle..kk.kteleitqyqylaWpdhgvPeskapllellrqvkvanqad.........tgpiivhCsaGvGrtgtFialdalidav

TQEKLVSVYQT
 .|. . |  |
eeedyiDvagt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 393-596 2.7e-43 143.1 In-house 46-239 (281) alignment 
Range on Protein: 393-596
Range on HMM: 46-239/281.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVT
|   |.  | .||.. |   .. .|||||....|..  ...|||| |. .. ...|.|.|... . |||.  | | .|     | |  . . ..||. |.
rYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvk

MESETARGDFIIRDLKLisTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQI
...|...  .| | .||  ... .  |........ ||.|| | . . .|.  ..|.. ... .|         |.|.||  |.||||.| ||  | ...
staeeekatyierkfkl..eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk........aplvihCsaGvGrtGtyialDrlvkav

TQEK
..|.
eael
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 393-603 2.4e-40 133.7 In-house 53-259 (325) alignment 
Range on Protein: 393-603
Range on HMM: 53-259/325.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMI--WQencRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFGDY
| . .  .| ||| |  .  .  ||||||||.  . ... |.|.| || .|. | ||..  |.    |.|..| | . .||    | |    .. .||  
rfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGgl

EVTMESETARGDFIIRDLKLISTKDPsVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNSHQfdiIGPIVVHCNNGIGRTGVYCALHALW
|| . .     |.. | |..  .|.    | .. |..  |.. |..    |.. ..  |.. .  |  |..     .||.||| .|.|||||. .|... 
evklrtieeisdyvhrvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantka...stpilvhcsaGvGrtGvfislysal

QQITQEKLVSVYQT
... .|  | ... 
akvieesrvdifgf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 393-602 5.2e-37 122.1 In-house 45-263 (301) alignment 
Range on Protein: 393-602
Range on HMM: 45-263/301.0
RVPRICVIDSSRVRLYPRPG--EEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA-VHDTAHFGDY
|   | |.|  |. | | |       .|||||||||......|||.| |...| .|.||.||||   ||||.  .||  |.    | |   ... .||  
rfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpf

EVTMESETARGDFIIRDLKLISTKDPS---V-----------IRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnshqfdiiGPIVVHCNNG
.||. .|..  ||.||.|... ..  .   .            ...  ..   ||..|     .|||| . .|   .  ...        ||.|||| ..
tvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigg........gpvvVHCSdt

IGRTGVYCALHALWQQITQEKLVSVYQ
..|.||||..     |   |  | |.|
VsrsGvYcsvsiglEQckaegVVdvfq
subfamily_PTPN14_pd Subfamily PTPN14 393-602 1.3e-33 111.3 In-house 54-266 (300) alignment 
Range on Protein: 393-602
Range on HMM: 54-266/300.0
RVPRICVIDSSRVRLYPRPGEeGSDYINASYIDGF--TRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV---HDTAHFG
|.. .   . .||.| |   .  ..||||| |     ...  .|..| ||. |  |.|.|.|... . |||| .|.|  |.   .|.|     ..|..||
rfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefg

DYEVTMESETARGDFIIRDLKLISTKdPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHA
 ..|| .  .  . .| . |||      .  |.. |. .  ||.|| |   .. |. . .|.    ........ .   |..||| .|.|||||      
kfkvttkfsedsdsvittglklkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdl

LWQQITQEKLVSVYQ
| . . ... . . .
liatlehneeidikk
subfamily_egg_pd Subfamily egg 393-585 9.7e-21 68.7 In-house 45-221 (307) alignment 
Range on Protein: 393-585
Range on HMM: 45-221/307.0
RVPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWdkDVFPSYLPA-VHDTAHF--GDY
| .|.   |||||.|  | |    |.| | ...|    . || .| ||. |  |.|||..||... |||| | ||   .  . | |    |.. .  | .
rskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGsl

EVTMESETARGD--FIIRDLKLISTKdpsvirqiR-HFHFLHWpehgqpwsgQTVLQLVSKVeEWESEVEKNSHQfdIIGPIVVHCNNGIGRTGVYCAL
...      . |  | .  |||. ..        .   .  ||         |  .. .|.|  .  .| .   .  .  |.||.. .|. ....  |.
rienlkvdskadplfrvtklklvGgd........deerflehw.........qgdvnnssdv.ysplrvlrklrn..lskpvvvqdilGvskaatlvai
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 394-606 2.6e-38 126.6 In-house 9-213 (237) alignment 
Range on Protein: 394-606
Range on HMM: 9-213/237.0
VPRICVIDSSRVRLYPrPGeEGSDYINASYIDGFTR-REAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVT
   | . | ||| |   .|  |||||||.|..||      .||.| ||.|.  |.|.|.|||.|  ||||    | ..     | |  .. | .| . |.
ygnivaydhsrvvlkg.ag.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvs

MESETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeeweseVEKNSHqFDIIGPIVVHCNNGIGRTGVYCALHALWQQI
.  . .  |. .| | |        .| |  ..|  ||..| |    ..|..  ..      .... |     || ..||. |.||||..  . |. .| 
lkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni......inrsph.vsesgpwiihcsagvgrtgiflvidamlrqa

TQEKLVSVYQTAWL
 ..|.| .|.  . 
kekkvvdiynyvys
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 394-602 1.3e-28 94.8 In-house 14-211 (239) alignment 
Range on Protein: 394-602
Range on HMM: 14-211/239.0
VPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFT-RREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPavHDTAHFGDYEVT
   |   | ||| |     .  ||||||||.  .    .|.||||  .. .. |.|||.|||    ||||    |  |     | |    |... .  ||
yanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvt

MESETARGDFIIRDLkLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewesevEKNShqFDIIGPIVVHCNNGIGRTGVYCALHALWQQI
.       |.||| . ..|    .  | . ..||  ||..| |    .|| |  |.        |.|  .    | |.||. |.|||| .  . |. .| 
lrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.......tkds..lpgarpwvihcsagvgrtgaflvidamlrqa

TQEKLVSVYQ
 ..| | ...
kkqktvdifn
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 394-602 1.3e-28 94.8 In-house 13-210 (239) alignment 
Range on Protein: 394-602
Range on HMM: 13-210/239.0
VPRICVIDSSRVRLYPRPGEEGSDYINASYIDGFT-RREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPavHDTAHFGDYEVT
   |   | ||| |     .  ||||||||.  .    .|.||||  .. .. |.|||.|||    ||||    |  |     | |    |... .  ||
yanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskycnlrvt

MESETARGDFIIRDLkLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewesevEKNShqFDIIGPIVVHCNNGIGRTGVYCALHALWQQI
.       |.||| . ..|    .  | . ..||  ||..| |    .|| |  |.        |.|  .    | |.||. |.|||| .  . |. .| 
lrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki.......tkds..lpgarpwvihcsagvgrtgaflvidamlrqa

TQEKLVSVYQ
 ..| | ...
kkqktvdifn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 394-593 2.3e-24 80.5 In-house 43-228 (281) alignment 
Range on Protein: 394-593
Range on HMM: 43-228/281.0
VPRICVIDSSRVRLYP-RPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA-VHDTAHFGDYEV
   | ..| |||.|    | .. .||| | ||     .  .| || | . |  |.||||||||  .||||    | ...    |.|   |   .|  . |
ylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsv

TMESETARGDFIIRDLKLISTKDpsvIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEwesevekNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQ
. |  |    ..   |.|    .    | | |. .  ||.   | | . .|... |.          |       | |.||  |.||.|   |.    | 
syedstvnkslvttrlnlsyege...trlithwlwkewpdwqvpessevmlkilrkira.......rst......ppvihcsagvgrsgtlmaveialqs

IT
| 
ih
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 394-597 7.5e-23 75.8 In-house 39-260 (297) alignment 
Range on Protein: 394-597
Range on HMM: 39-260/297.0
VPRICVIDSSRVRLypRPGEEGSDYINASYIDgFTRRE---AFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVH-DTAHFGDY
   |   |..||.|  . .  ..||||| |.  |   |    .| .| ||..|  |.|....... | |||.   .|  .|    | | |  .  . ||.
yrdilatddtrvkl..lrviterdyinadyvv.fpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdv

EVTMESETARG--DFIIRDLKLISTkdpSVIRQIRHFHFLHWPEHGQPWSGQTVLQ--------------LVSKVEEWES----EVEKNSHQFDIIGPIV
 |   |.|.      |. .|.||     |  |..||  || ||.|| |   . . .              ... || . .    ..|    .     ...
vveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayll

VHCNNGIGRTGVYCALHALWQQITQEKL
|||  |.||.||    ... ... ....
vhcsaGvGrsGvvvlsdvilaklrkkri
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 395-603 1.4e-58 193.0 In-house 16-213 (250) alignment 
Range on Protein: 395-603
Range on HMM: 16-213/250.0
PRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDvFPSYLPaVHDTAHFGDYEVTME
  |  .||||| | .  |.. |||||||...|.. |.||||||.|||.|. |.|||...|.  .|||| . || .|  .. |.| |  . ..||  |.. 
adiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.vekaekyGdvtvsll

SETARGDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQ
|.   .|...| ||| ..|  .  |..|..||. ||. | |   ..||.|..||.  . ....        .|..|.| .|.||.| ..|..|. ... .
skeefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagn........aPvivqCsaGvgrsGafiaidavlerlkk

EKLVSVYQT
|| | |.. 
ekvvdvfkv
subfamily_PTPN3_pd Subfamily PTPN3 395-597 3.6e-40 132.7 In-house 48-240 (280) alignment 
Range on Protein: 395-597
Range on HMM: 48-240/280.0
PRICVIDSSRVRLYprpgEEGSDYINASYI----DGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYE
  |.  |. ||.|     |. .|||||.|.    .. .    .|||| ||..|. |.|.|.|..... |||| .  |  .     | |  .|. ..|...
rdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefs

VTMESETARGDFIIRDLKLISTKdPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWEseveknshqFDIIGPIVVHCNNGIGRTGVYCALHALWQ
|..|.| ..  ...|.| |  ..  .  |.| .. .| ||.|| | . . .|..|..|..                |.||||  |||||||. .|    .
vkcekedetksyvlrelvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklr.........sgkeePvvvhCsaGigrtGvlilletala

QITQEKL
 | ... 
lieaaep
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 395-600 9.5e-33 108.3 In-house 55-247 (439) alignment 
Range on Protein: 395-600
Range on HMM: 55-247/439.0
PRICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKdvfpsYLPAVHDTaHFGDYEVTME
  .   | .|| |   ||   | |||| ||.|.   . .|||| | . || |.||.......  ||||    |  |     | |.  ..  .||  | ..
kdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev.cygdiavrvd

SETARGDFIIRDLKLISTKDPS-VIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEeweSEVEKNShqfdiIGPIVVHCNNGIGRTGVYCALHALWQQIT
 .    ...|| .|..  .| .   | . .||.. ||..  |     ||...  ..   |  .|.      .||.||||  |.||||   ||    .|. 
rnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrain...sandkee.....ygpvvvhcsagvGrtGtiialdialeqlk

QEKLVSV
 |. | .
lenkvdi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 396-611 1.8e-62 206.2 In-house 54-259 (318) alignment 
Range on Protein: 396-611
Range on HMM: 54-259/318.0
RICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGDYEVTMES
 |   |..||.| .. ||||||||||.||||..|..|.||.| ||  |  |.|||.|. |.. ||||  |.|  |.    | |  ... ..|.  |....
nilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs.kgsrsygklvvelke

ETARGDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQE
|.  .|...| .|.  |.  .  ||.| .|.  ||..| | || ..|.|| .|.... . ..        |||||||  |.|||||..|. .| ..| .|
evelsdyvlrefkvtrtee.eesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga........gpivvhCsaGvGrtGvfiavdillerikae

KLVSVYQTAWLQGHQR
.|| |.||     .||
alvDvfqtvkqlreqr
subfamily_PTPRG_pd Subfamily PTPRG 396-611 1.4e-56 186.9 In-house 55-266 (563) alignment 
Range on Protein: 396-611
Range on HMM: 55-266/563.0
RICVIDSSRVRLYPRPGEEGS-DYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvHDTAHFGDYEVTME
 |  .|.|||.| | ||.... |||||.||||. . .||||||.||..|. |.|||||..|   |||.   .|  .   . | |.  .. ..|  .||..
nivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtli

SET-----ARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewesevekNSHQFDIIGPIVVHCNNGIGRTGVYCALHALW
.|      .   ..|..|||  .|.    ...|..|. .||.|| | .   ||. | |          .  . . .|||||||..|.||||.|..| .| 
eeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.........saankaeaGPivvHcsaGvgrtGtyivldtll

QQITQEKLVSVYQTAWLQGHQR
.|| ||. | |....     ||
kqiqqenavnvfgflkhiraqR
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 396-598 8.9e-36 118.1 In-house 46-243 (287) alignment 
Range on Protein: 396-598
Range on HMM: 46-243/287.0
RICVIDSSRVRLYpRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVTMES
 .  || .|| |    || ||||||| |. ..|. |||||.| |. .|  |.||......  |....  | |  .     | |  .     | | |.. .
dvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlld

ET-ARGDFIIRDLKLISTkDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWeSEVEKNSHQfdiIGPIVVHCNNGIGRTGVYCALHALWQQITQ
 .    .. .| |.||   .    | .. ...| ||... . .   ....| .|..   |..... .   .||.|||.. ||||.|.. |. .| ..  .
ydikePeygvralrlidl.etrearvvkqldllswPdkvlaPtavglirfvldvkqh.ielardase...vGPlvvhddvGiGrsGillatlvlvsrled

EKLV
   |
lGrv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 396-602 1.4e-27 91.1 In-house 53-206 (392) alignment 
Range on Protein: 396-602
Range on HMM: 53-206/392.0
RICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDkdvfpsylpavhdtahfgdyevtmes
 |  .||.||.|        |||.|||||..|   .|.||.| |  ..  |.|||..|||  .|.|.   || |                          
nilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........................

etargdfiirdlklistkDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewESEVEKNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQITQE
                       | .  |||  ||... |    ..|... .|   ...  . .|      |...||. |.|||||  .. ..  .  . 
..................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqyth......pliihcsagvgrtgvvisidsvvahakkt

KLVSVYQ
..| |..
rmvdvfn
subfamily_ptpA1_pd Subfamily ptpA1 396-586 2.7e-27 90.5 In-house 55-250 (418) alignment 
Range on Protein: 396-586
Range on HMM: 55-250/418.0
RICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRrEAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD----------TAH
 |  .. .||.|     .|||||||| ||||    . ||.|| ||  |  |.|||.|.. || ||||  | |  .     | |                 
nilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnev

FGDYEVTMES--ETARGDFIIRDLKLISTKDpsvIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNShqfDIIGPIVVHCNNGIGRTGVYC
|| | | .    .    . | |...|    .    |.| ....  ||.|  |   | . ||.  . . . ..  .|   |   ||.|||. |.|||| .|
fgtysvelveviqdpereiitrnirltfege...trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipss...drnvpiivhcsagvgrtgtfc

ALH
.  
tav
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 396-585 2.2e-17 58.0 In-house 51-224 (288) alignment 
Range on Protein: 396-585
Range on HMM: 51-224/288.0
RICVIDSSRVRLYprpgEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVH-DTAHFGDYEVTME
..   | .||.|     ..   ||.|  .     .. .| .| ||..|   .|.|. ... . ||||    |  |.    |.| .  ..|..| .   . 
nlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvk

SETARGDFIIRdLKLISTKDPSVIRQ-IRHFHFLHWPEHGQPWSGQTVLQLVSKVeeweseveKNSHQfdiigPIVVHCNNGIGRTGVYCAL
 . |  | ... . |.  . .   .. ... |.|.|...| | . .. |.|.  .        |. ..     |||||...|.||||     
kkradidklvk.vsllriskegeekvivkilhlleWdddgvPenylsplrllevl........kslqk.....PivvhssaGvGrtgtlili
subfamily_PTPN6_pd Subfamily PTPN6 397-597 1.6e-52 173.4 In-house 63-259 (306) alignment 
Range on Protein: 397-597
Range on HMM: 63-259/306.0
ICVIDSSRVRLYpRPGEEGSDYINASYIDGFT--RREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVTME
|   | .|| |  .|.  |||||||.||.. .   ....||||  |..|  |.|||.||||.| |||.  | |  |.    | |..... ..|...||. 
ilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnv

SETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdIIGPIVVHCNNGIGRTGVYCALHALWQQITQ
||..  |.|.|.|..  .|. .  |.....||  ||.|| | . ..||.....|.. ..|.|..       |||||||..|||||| .  . .| ..|..
seksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea.....eagpivvhCsaGiGRtGtfiviDillkliek

EKL
..|
kgl
subfamily_PTPN9_pd Subfamily PTPN9 397-611 1.2e-50 167.2 In-house 51-269 (297) alignment 
Range on Protein: 397-611
Range on HMM: 51-269/297.0
ICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLP-AVHDTAHFGDYEVTMES
.  .|..|| |  ....| ||||||...||. ...|||||| ||. |. |.|||.|..... |||     |  .     | |   ...|.|||..|.  .
vlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnve

ETARGDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEK---NSHQFDIIG-PIVVHCNNGIGRTGVYCALHALWQQ
   . |. .| |..  .|. . .|.. || || ||..| | |....|....|| |  . . |   ....... | ||||||  |||||| ...|    ..
veeeedykvrvleiknvkt.eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsr

ITQEKLVSVYQTAWLQGHQR
. ..  | | .|  |   ||
leevgtvdvvetvkllrtqr
subfamily_PTPN23_pd Subfamily PTPN23 397-596 3.1e-48 159.1 In-house 52-243 (288) alignment 
Range on Protein: 397-596
Range on HMM: 52-243/288.0
ICVIDSSRVRLYprpgEEGSDYINASYIDGFTRR-EAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD-TAHFGDYEVTME
|   |..|| |     ..  ||||||.. . .     ||||| |||||  |.|.|....  . ||||||..| .|    .| |. .. | .|||..||..
ilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlk

SETARGDFIIRDLKLiSTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNSHQfdiigPIVVHCNNGIGRTGVYCALHALWQQITQ
|..  . .. |.||| .|.|.. .....| ..  |||.| | | .|.||.. .||.  ..|...|..     |.||||  |.|||||.. . |  .....
svretethvervlkl.etldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.....PlvvhCsaGvgRtgvfalvyaavrelek

EK
..
gn
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 397-602 3.9e-46 152.3 In-house 37-238 (274) alignment 
Range on Protein: 397-602
Range on HMM: 37-238/274.0
ICVIDSSRVRLYPRPGEE-GSDYINASYIDGFTRR-EAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDT---AHFGDYEV
|   . ||| | .. .|.  |.|||| || |. .. .|..||| ||..| .|.||||.||... ||||   || ...    | |  .|.    ..|| |.
ilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdvei

TMESETARGDFIIRDLKLISTKDpsvIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeeweseV----EKNSHqfdiIGPIVVHCNNGIGRTGVYCALHA
..|. . | |. .| | | ....    |.. |. . .||.| .| . .|.|.|| .|           |.| .    ..|.||||  ||||||.. | . 
kvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvlev......eesreeenak....lapvvvhCsaGiGrtGcfiaisi

LWQQITQEKLVSVYQ
  .|. .|. | | .
avrqlreeivvdvlk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 397-604 6.2e-44 144.9 In-house 52-248 (515) alignment 
Range on Protein: 397-604
Range on HMM: 52-248/515.0
ICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA-VHDTAHFGDYEVTMES
|  .||.||.|     .  |||.||||| .|    |.||.| |..... |.||...|||   |.|.   || ||     | |    |. .|| ..| . |
ilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvs

ETARGDFIIRDLKLISTKDpsvIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVeewesevEKNSHQFDiiGPIVVHCNNGIGRTGVYCALHALWQQITQE
  | .. |.| |...  .|   .| .  |||  ||..| |   ...|.|. .|         .  |.    |...||  |.|||||.....    .. . 
leactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikev.......kadhgqyt..hpliihcsaGvGrtGvvisidsvvahaktt

KLVSVYQTA
. | |... 
rmvdvfnfv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 397-603 2.5e-43 143.2 In-house 58-250 (315) alignment 
Range on Protein: 397-603
Range on HMM: 58-250/315.0
ICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVhdTAHFGDYEVTMESE
|   | |||.|     ...|||.||..|||..... .||.| |. ..  |.||....|..  |||| .  | .|     | |       .| . ||. ||
iiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkse

TARGDFIIRDLkliSTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESevekNSHqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQEK
    .. .| |   |.   . ||..  .|.  ||. | | .  ....|. .|  ..     ||      |.|||||..|.|||| ...| |. .|.  |.
evnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhht....nsv.....gaivvhcsaGvGrtGtfitldavldqaeaen

LVSVYQT
.. ||. 
aidvynf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 397-604 9.9e-42 137.9 In-house 53-249 (315) alignment 
Range on Protein: 397-604
Range on HMM: 53-249/315.0
ICVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA-VHDTAHFGDYEVTMES
|  .||.||.|     .  ||||||||| ..   .|.||.| ||...  |.|||..||.  .|||.   .| ||     | |    |...|| ..|.. |
ilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvells

ETARGDFIIRDLkliSTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEeweSEVEKNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQITQE
  | .| ..| |    |..    |..  |.|  ||..| .    ..|.|. .|    .. .|. .      ...|||  |.||||| ....   .|| ..
leadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevk...adngkkef......sllvhcsaGvGrtGvvisidevvaqikrt

KLVSVYQTA
. | |... 
rsvdvfnfv
subfamily_PTPN13_pd Subfamily PTPN13 397-603 1.8e-33 111.0 In-house 46-240 (273) alignment 
Range on Protein: 397-603
Range on HMM: 46-240/273.0
ICVIDSSRVRLyprpGEEGSdYINASYIDGFTRREA--FIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTA-HF-GDYEVT
.  .| .||.|    |.||. |||||.|      .   .||.| ||  |. |.|.|.|. ... |.|. .||| .|     | |  ..      . .||.
vlPydetrvkl....gdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrleve

MESETARGDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEveKnshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQI
..  . . .| .|.|... ..  .  |.. |..| .||.|| | | . .||.|..| . ...  .        |||||||  ||||.|.. ..... . |
llkvqkldgfvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtd..a........gPivvhcsaGiGrsGtlitidvvlgli

TQEKLVSVYQT
 ..| . | ..
erdkefdvkei
subfamily_PTPN1_pd Subfamily PTPN1 397-595 5e-32 105.8 In-house 41-231 (290) alignment 
Range on Protein: 397-595
Range on HMM: 41-231/290.0
ICVIDSSRVRLYprpgEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD--TAHFG--DYEVT
.   | ||..|     ..  |||||| ..    .  .| || || .|.  .|.|.|.......|||    | ..    .| |  ..  .  .    ..|.
vspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvk

MESETARGDFIIRDLKLISTKDpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnsHqfdiiGPIVVHCNNGIGRTGVYCALHALWQQI
. ||  .  ...| |.|   |     |.| |||.. ||. | | | .. |... || |  | ...  .     || |.||  ||||.| .| . ..  .|
liseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssd..v.....GpavihcsaGiGrsGtfclvdtclvli

TQE
 ..
ekk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 397-595 8e-21 69.1 In-house 57-249 (305) alignment 
Range on Protein: 397-595
Range on HMM: 57-249/305.0
ICVIDSSRVRLyprPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFG--DYEVTM
.  .|  ||.|    |    .|| | |.   |  . || || ||. |  |.| | .|..  .| ||   .|        |...  .|. .|   .  ...
vgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisv

ESETA-------RGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEeweseVEKnshqfdiiGPIVVHCNNGIGRTGVYCALH
  |..         .  ... .|.     .  |.. |.|.  ||. | | . ...|.|. |       . |        |||||||  ||||||    | 
kfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.....psk........gpivvhcsagigrtgsvvmle

ALWQQITQE
 . .|. . 
yildqllag
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 397-595 2.3e-20 67.4 In-house 61-253 (310) alignment 
Range on Protein: 397-595
Range on HMM: 61-253/310.0
ICVIDSSRVRLYPRPGeEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVTMESE
. . |.|||.|         ||| | |.     |..|| .| ||| | .|.||||.|| . ||..|    |  .    .| |..  |  .|   ||  ||
vvcldtsrvklkidks.ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlse

TArGDFIIRDLKLISTK-------DPSVIRQIRhFHFLHWPEhgqpWSGQTVLQlvskveEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALW
..  .| | .| .           .|. ....|   ...||.    |  . | .      |    | .        || ||||  |..|..| .||.  .
ss.eefeicnlavtfvpdnvpvdeqpanlkelr.vslikwpn....wpdrgvpd......ekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklki

QQITQE
... . 
dkldrg
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 397-585 1.8e-16 55.0 In-house 44-223 (285) alignment 
Range on Protein: 397-585
Range on HMM: 44-223/285.0
ICVIDSSRVRLYprpgEEGSDYINASYIDGFTR-REAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA-VHDTAHFGDYEVTME
. .|. .|| |     .   ||| ||..    . . ..|.|| ||  |  |.|.||.||.   ..|| .  |   .    | |  . .  .|| ||.|. 
vrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlt

--SETARGDFIIRDLKLISTKDPSV-IRQIRHFHFLHWPEHGQPWSGQTVLQLVSkveeWESEVEKNSHqfdiigPIVVHCNNGIGRTGVYCAL
   | |    |.  | .| |.| |     . | .   ||..  |   . ...|      |  .|. . .      ||.|||. |.|||  .  .
eckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielyk....wvkkvnpkek......picvhcsagvgrtatfvgi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 397-586 3.2e-14 47.2 In-house 56-232 (303) alignment 
Range on Protein: 397-586
Range on HMM: 56-232/303.0
ICVIDSSRVRLyprpgeEGSDYINASYIDGFTRREAfIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVTMeSE
. ..| |.|.|        | || |||..  ... | | || ||. |. |.|.|| ... . ...||.. |.||    | .|   |  .| .  . .  |
vicldhskvkl......sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirv.ge

TARGDFI-IRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTvlQLVSKVEEWESEVEKNSHQfdiiGPIVVHCNNGIGRTGVYCALH
  | ..     ||..|  . .    .   |.  ||    |  |    ..| .. . .| . | |.      | |     | ||.| .. . 
fkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrkysds....tptvymslsgcgragtfalfe
subfamily_eak_pd Subfamily eak 397-590 1.3e-11 38.4 In-house 60-261 (332) alignment 
Range on Protein: 397-590
Range on HMM: 60-261/332.0
ICVIDSSRVRLYPRPgEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVH-DTAHFGDYEVTMES
|   |   ||| .    .   ||||| ..     . .| |  . ..  . .|.|. ...  .||.|| . | . . .  |.|    .  .|| ..|.  .
ivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverke

ETARGDFIIRDLKLISTKDpsvIRQIRHFHFLHWPEHGQPWSGQ-----------TVLQL-VSKVEEWESEVEKNSHQFDIIGPIVvHCNNGIGRTGVYC
   |. .  | |.|    .     .. |...  | |   |   .            ||.| | | .  .| . |  |      ||.  . .|  |.||. 
fvkrniletrllelskGne...thrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii.qsarGsaraGvfv

ALHALWQ
 .  | .
vidllir
subfamily_CG7180_pd Subfamily CG7180 398-604 1.5e-45 150.1 In-house 52-262 (296) alignment 
Range on Protein: 398-604
Range on HMM: 52-262/296.0
CVIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKdVFPSYLPAVHdTAHFGDYEVTMESET
   |  || |    ||| ||||||.|.|.|.. ...| |. | ..|  ..||....|.. ..|.|  . .  |  .|||.|     ...|. .| . .| 
vPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveek

ARGDFIIRDLKLIST---------KDPSVIRQIRHFHFLHWPE-HGQPWSGQTVLQLVSKVEEWESEVeknsHQFDIIGPIVVHCNNGIGRTGVYCALHA
   .. || .||  .         .     | ...|..  |.  .  |.| .....|. .|. |  .|    .. .  ||.||....| .|.|||.|. |
qyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv....dedpeegPvvvvssdGasRsGvylaida

LWQQITQEKLVSVYQTA
  ... .|. | |.. .
nlelvekeeevdvFeav
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 398-604 7.8e-11 35.9 In-house 61-257 (302) alignment 
Range on Protein: 398-604
Range on HMM: 61-257/302.0
CVIDSSRVRLyprpGEEGSDYINASYIDGFTRREAFIATQHPLQSTT---MDYWRMIWQENCRSIVMLLSEKEWDKdVFPSYLP-AVHDTAHFGDYEVTM
 ..|| .|.|    ..|  .|.||| ..    ..  | .| | ....    ..|||..||.. |.|.|. |.| .|  .  ..|    |  ..|.  |  
pildsnlvkl....eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNn

-----ESETArGDFIIRDLklISTKDPSVIRQIRHFHFlhWPEHGQPWSGQTVLQLVSKVeeWESEVEKNSHqfdiigpIVVHCNNGIGRTGVYCALHAL
      .|..   ..|  |        ||. .. ....  |...  | .  .. . . ||  ...... ...       .|.  .||.|| |.  .| . 
rkVekaeeek.tryviEvl..Pegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakv..fakkikaden.......tvivSknGaGRagafltlava

WQQITQEKLVSVYQTA
 ......| . . ...
veklqkgkepnikeiv
subfamily_PTPN12_pd Subfamily PTPN12 399-610 6.6e-49 161.3 In-house 51-255 (290) alignment 
Range on Protein: 399-610
Range on HMM: 51-255/290.0
VIDSSRVRLYPRPGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAH-FGDYEVTMESET
  | ||| |    .|||||||||..| | . . ..||.| ||  |  |.|||||. | . .||.  | | .|     | |  ....  ||..|||.|.| 
PydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeek

ARG-DFIIRDLKLISTkdpSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveknshQ--FdiigPIVVHCNNGIGRTGVYCALHALWQQITQ
|   ||.|| ||.      .  |... ||. .||.|| | | ...|.|...|.| ..       .       |.||||  |.||||. .|.   .... .
avdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.......seda....PlvvhCsaGvGrtGtiiaidyvrellka

EKL---VSVYQTAWLQGHQ
||.   ..|..  .   .|
ekipeeldvfdlvlelrkq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 399-604 1.1e-41 137.9 In-house 62-256 (297) alignment 
Range on Protein: 399-604
Range on HMM: 62-256/297.0
VIDSSRVRLYPRPGEEGSDYINASYIDGFTRreAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKdVFPSYLPAVHdTAHFGDYEVTMESETA
 .|||||.|  .  .  |||.|||.. |.     .|.|| | ..|  |.|.|...|.   ||||  ..| ||     | .    .. |||  |...| . 
PydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg.vttfGdvsvvllsvse

RGDFIIRDLKLiSTKDPSVIRQIRHFHFLHWPEHGQPW--SGQTVLQLVSKVEEweseveknSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQQITQEK
|  || |.|.. .  .. . | .. ..|..||..  .   | ...|.|.| |..        ...    ||..||| .|.|||||....     .. .||
reGfikrelev.tkgkakarrvvkqyqfveWPdkaverkdsassllklisevrk........dfsqnaegPllvhclaGvGrtgvlltidsvvaeakrek

LVSVYQTA
 | .... 
evdifglv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 399-588 2.8e-20 67.5 In-house 52-232 (307) alignment 
Range on Protein: 399-588
Range on HMM: 52-232/307.0
VIDSSRVRLYpRPGeEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD-TAHFGDYEVTMESET
..| .|. .   .|   |||| | |.   ..   ||..| ||..|  ..| |. ||.  |..||    |  |     | |...  .  ||.   |.  . 
cqdkgrivvk.fdg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvan

ARGDFIIRDLKLISTKDP-----SVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEwesevEKNshqfdiigPIVVHCNNGIGRTGVYCALHAL
   . .  | .||   .      .  | |.|. .  ||..| |    | . |.. |.      ..|        |.||||  |.||.|   |.  .
lgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry.....dtn........pvvvhcsaGvGrsGtivaislv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 399-595 4.5e-14 47.3 In-house 29-221 (290) alignment 
Range on Protein: 399-595
Range on HMM: 29-221/290.0
VIDSSRVRLYPRPGEEGSDYINASYIDgFTRREAFIATQHPL-------QSTTMDYWRMIWQENCRSIVMLLSEKEWDKD--VF--PSYLPAVHD-TAHF
..  .|| |        .||| |...  .    ..|.|| |.       .||  ..| |. ||. ...|||   .| ...   |    | |   .    |
LveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

GDYEVTMESETARGDFIIRDLKLisTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESeveknshqfdiigPIVVHCNNGIGRTGVYCALH
.. .|   |  .  |...| | .  . |  .  .. |  .  | .   . . .|.|.|..||.  ..             |..||| .|| |  .  |. 
kgltvkCkskekeddvetRelvv..kfddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt.............pvivHcvdGiSrsAalaaii

ALWQQITQE
  .| | . 
lgyQkiaet
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 399-463 1.5e-07 25.3 In-house 48-117 (347) alignment 
Range on Protein: 399-463
Range on HMM: 48-117/347.0
VIDSSRVRLYPRPG-----EEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLL
.||..|| | |        ..   |||||.|     .. .| ||.|| .|  |.|.|.   .   .| ..
lidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
0044763 (Phosphotyrosine protein) phosphatases II 400-591 5.7e-25 83.4 In-house 2-136 (178) alignment 
Range on Protein: 400-591
Range on HMM: 2-136/178.0
IDSSRVRLYPRPGEEGSDYINASYIDGFtrreaFIATQHPLqsttMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDtahfgdyevtmesetar
.| .|| |....|.|.|||||||.|...     ......|      |............||.| .|.|. .   . | |  ..                 
ldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................

gdfiirdlklistkdpsvirqiRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESevEKNshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQ
                       .......| || | . . .|..|  .||. .  ||.       ||..|||. |.||.|. .|.  ....
......................iqylhipipDhgvpdllehflefvefieeald..ekg.......gpvlVHCsaGvgRsgtlvaaylmkkl
subfamily_CG42327_pd Subfamily CG42327 400-548 9.9e-24 78.6 In-house 40-190 (319) alignment 
Range on Protein: 400-548
Range on HMM: 40-190/319.0
IDSSRVRLYPRPGEEGSDYINASYIDGFTRR-EAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPA---VHDTAHFGDYEVTMES
.  .|| |   . .. . |..|||. |.      .||.| .|.... |.||..|. . | || | .  |   .| . |||.     .|  .||. ||.  
lPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkg

ETARGDFIIRDLkLISTKDPSVIRQIRHFHFlHWPEHGQPWSGQTVLQLVSKV
  ..  ..|  | |.   | .  |.. |. . .|.| . | . .... .. .|
revkdryaistl.llkrvdkeesrelthywy.kwleaevPaeeaaliamllev
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 401-598 1.6e-36 120.7 In-house 33-230 (270) alignment 
Range on Protein: 401-598
Range on HMM: 33-230/270.0
DSSRVRLYPRPGEEGSDYINASYIDGFTR-REAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDT---AHFGDYEVTMESE
  .|||| .   .. . |||| |. ||.  ....||.. ||..|. ..|||||.|. ..|||.   .|  ..    | ||  ..    ..|. .|. .||
PatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalse

TARGDFIIRDLKLIstkDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLvSKVEEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQQITQEK
. .  .|.. |.|    . . .|.. ||.. .||.|| | . ...|.  ... .   .| . ....|  .|..||| .|.||||.  ||    . . ..|
ekeegyiltrlrle...ekgeerrlvHfwyntWpdhgvpreedsslst.dqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetk

LV
 |
kv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 401-600 1.2e-26 88.1 In-house 69-251 (290) alignment 
Range on Protein: 401-600
Range on HMM: 69-251/290.0
DSSRVRLypRPGEEGsDYINASYIDGFtrREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHD-TAHFGDYEVTMESETAR
| .|| |  . | .| ||. | |..|   .  || || .|..|..|.|||. ||.   ||||    |  |     | |  .  .  ||.. |.   |. .
dktrvil..kdGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddk

GDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEeweseveKNShqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQEKLVS
 . ||. .  .  ||     ...|..   ||..  . |  ..|...  .        | |      ||.||||  |||||| . |. .  | ... | . 
daniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilr.......kas......GpvvvhcsaGiGrtGtfvaievglqilldGkeld

V
.
l
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 401-596 2.1e-17 57.7 In-house 68-252 (305) alignment 
Range on Protein: 401-596
Range on HMM: 68-252/305.0
DSSRVRLYpRPGeeGSDYINASYIDG-FTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHFGDYEVTMES----
| | |.|  .|    |||| | |.   .     ||..| ||. |  ..| |. |..   ||||    |  |     | || .   .     . .|     
dqsavkld.kps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgs

ETARGDFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEweSEVeknshqfdiigPIVVHCNNGIGRTGVYCALHALWQQITQE
     |  |.   |  |   .    .||... .||. | |    | |.|.| .    |.|           ||||||  ||||||   |.  . ..|...
kpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg..skv...........pivvhcsagigrtgtivaieyilekiaen

K
|
k
0046846 (Phosphotyrosine protein) phosphatases II 406-599 5.2e-31 103.1 In-house 2-145 (176) alignment 
Range on Protein: 406-599
Range on HMM: 2-145/176.0
RLYPRPGEEGSDYINASYIDGFtrreAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTAHfgdyevtmesetargdfiir
||...  ....|||||..|.|     ..||||.|| .|..|...|....... .|.|..|.| ..  .| | | ...  .                    
rlrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

dlklistkdpsvirqirHFHFLHWPEHGQPWSgQTVLQLVSKVEEWESEvekNshqfdiiGPIVVHCNNGIGRTGVYCALHALWQ--QITQEKLVS
                 ....|.||.|| | . . .|.|.  ..|. .|   .       ||..|||  ||||||...|.  |.   ... |. ..
.................qylhlpwpDhgvpdl.elllellefirealke...g.......gpvlVHCsaGigRtgtlvaayllelekglsveeala
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 411-470 7e-12 39.5 In-house 117-176 (244) alignment 
Range on Protein: 411-470
Range on HMM: 117-176/244.0
PGEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDK
 |  |  |||||..  . |   .| |||||  |.||.|.|. .     .|.| | .| |.
kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede
0043147 (Phosphotyrosine protein) phosphatases II 412-603 1.2e-31 105.1 In-house 1-138 (172) alignment 
Range on Protein: 412-603
Range on HMM: 1-138/172.0
GEEGSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEkewdkdvfpsylpavhdtahfgdyevtmesetargdfiirdlkliS
|.||||||||||.|.      ||||| ||..|. |.|||....... ||.| ..                                              
gdegsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................l

TKDPSVIRQIRHFHFLHWPEHGQPwSGQTVLQLVSKVEEWESEVEKnshqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSVYQT
.  . . |.. ....| || || | . . .|.... ..|.  . ..        ||..|||  |.||||. .|.. ...... |. |. ...
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspg........gpvlVHCsaGvgRtgtlvaaylmllglsleeavalvre
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 414-476 3.9e-10 34.0 In-house 81-149 (350) alignment 
Range on Protein: 414-476
Range on HMM: 81-149/350.0
EGSDYINASYIDGF----TRREAF--IATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSY
...|||||.|.            |  |||| ||.||  |....| . . . |..| |. | . . .  |
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY
0051429 (Phosphotyrosine protein) phosphatases II 415-599 4.6e-36 120.2 In-house 3-184 (272) alignment 
Range on Protein: 415-599
Range on HMM: 3-184/272.0
GSDYINASYIDGFTR---REAFIATQHPLQSTTMDYWRMiWQENCRSIVMLLSEKEWDKDVFPSYLP-----------AVHDTAHFGDYEVTMESETARG
 |.||||....|..|   . .......||. |  |.||. .......||.| || | ... .. |.|            .. |  .|.. ||. ||.   
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DFIIRDLKLISTKDPSVIRQIRHFHFLHWPEHGQPWSGqtVLQLVSKVEEweseveknshqfdiIGPIVVHCNNGIGRTGVYCALHALWQQITQEKLVS
|.|.| | |. . ... .|...|.|.. || || | .   .|.|.. . .               ||..|||. |..|||...||  | .... |  | 
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld..............ggpvlvHCsaGkdRTGtvvallllllgvsletivd
0036282 (Phosphotyrosine protein) phosphatases II 415-606 1.8e-32 107.8 In-house 1-144 (174) alignment 
Range on Protein: 415-606
Range on HMM: 1-144/174.0
GSDYINASYIDGFTRREAFIATQHPLQsttmdYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAvhdtahfgdyevtmesetargdfiirdlklistKD
||||||||..|.. . . .||.|.||.     .|.|.........||||.|||...  .. | |                                  . 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lr

PSVIRQIRHFHFLHWPEHGQPWSGQtVLQLVSKVEEWESEveknshqfDIIGPIVVHCNNGIGRTGVYCALHALWQQITqEKLVSVYQTAWL
 .  | . ....|.|| || | . . .|..|. |||. ||        |  ||..|||. |.||||. .|.  . ...  |.|| ....   
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealse........dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvre
0051082 (Phosphotyrosine protein) phosphatases II 415-602 4.5e-27 89.9 In-house 2-129 (151) alignment 
Range on Protein: 415-602
Range on HMM: 2-129/151.0
GSDYINASYIDGFtrreaFIATQHPLQsttmDYWRMIWQENCRSIVMLLSEKEWDkdVFPSYLPAVHdtahfgdyevtmesetargdfiirdlklistkd
 |||||.||..|.     ......||.    |............||.| ||.|..   .|.|||.                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

psviRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEwesevekN-ShqfdiiGPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSVYQ
    ....|...| ||..| | | ..||........       . .      ||..|||. |.||||. .||  . .... |. .. |.
....ievlhipildwpdpglplsfdavleflellld.......kkn......gpvlvHCsaGkgRTGtlvalylmllgvsleealeeyr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 415-612 2.5e-24 80.7 In-house 56-239 (267) alignment 
Range on Protein: 415-612
Range on HMM: 56-239/267.0
GSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEkeWDKDVFPSYLPAVHDTAHFGDYEVTMESETARGDFIIRDLKLIStKD
  .||||||..|. ...|||.|| ||. |  |.. .| ....  ||.|        ..   . | . .. .. |  |    |    |. |  |.|   |.
eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv..ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.kn

PSViRQIRHFHFLHWPEHGQ--PWSgQTVLQLVSKveeweSEVEKNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSVYQTAWLQGHQRP
 |  ...  ... .|    .  |.  . .. ...|      ..|. ..      |.||.|..|.||.| .  ...  ... .|  . ...      .||.
esa.hnvtlyyykkwnintnnkpyl.kplfgilak.....nqlengnr......PlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqri
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 415-474 5.8e-09 30.3 In-house 12-70 (130) alignment 
Range on Protein: 415-474
Range on HMM: 12-70/130.0
GSDYINASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDkDVFP
| .|||||..    |   .. |||||  |.||.|.|. .     .|.| | .| | . .|
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.eywp
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 416-467 2.2e-07 24.6 In-house 90-143 (349) alignment 
Range on Protein: 416-467
Range on HMM: 90-143/349.0
SDYINASYID--GFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKE
 ||||| |.    ..  . .|||| || ||  |....|  .. . .. | ..||
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 419-600 5e-23 76.3 In-house 78-249 (301) alignment 
Range on Protein: 419-600
Range on HMM: 78-249/301.0
INASYIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAV-HDTAHFGDYEVTMESET--ARGDFIIRDLKLISTKDP
| | .|.   . . ||||| ||..|. |.| |. | .   ||||  . |  ...  .|||   ... . | ........    . . . | |..  . . 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

SVIRQIRHFHFLHWPEHGQPWSGQTVLQLVskveewesEVEKNSHQfdiigPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSV
   | . |. . .|...| | |   . .|.        |. |.|..     ||||||..||||.  . . . | ...  .. . .
fatrtvthyqysewtdrgvPkshaelfdlm........elvkksek.....PivvhcsaGiGrsvafigteylareveadptiel
0049260 (Phosphotyrosine protein) phosphatases II 423-602 5.1e-27 89.8 In-house 1-126 (152) alignment 
Range on Protein: 423-602
Range on HMM: 1-126/152.0
YIDGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLpavhdtahfgdyevtmesetargdfiirdlklistkdpsvirqir
.|||. .  .|||||.|.  |. |.|||... ... |||| .. | .|. .. |                                              
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

HFHFLHWPEHGQPWSGQTVLQLVSKVEEWeseVEK--NshqfdiigPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSVYQ
....| || || | . | .|.|.  .|..    ..  .        |..|||  |.||||...|.  ...... |. |. ..
qylhlpwpDhgvpdlsqlllflllfiekl...aldkgg........pvlVHCsaGvgRtgtlvaaylmllgvsleeavalvr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 425-608 7.4e-19 62.4 In-house 230-414 (440) alignment 
Range on Protein: 425-608
Range on HMM: 230-414/440.0
DGFTRREAFIATQHPLQSTTMDYWRMIWQENCRSIVMLlsEKEWDKdVFPSYLPAVHDTAHFGDYEVTMESETARGDFIIRDLKLISTKDpsvIRQIRHF
.|.....|||||| ||.|| .|.||.. . .  .|.||  ..  ||     | |    .  || . |            .| |.|   ..   . .|| |
egyskknafiatqmpldstvldfwrlvhdyristiiml..nqlndk.tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykee...vheirqf

HFLHWPEHGQPWS-------GQTVLQLVSKVEEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQQITQEKLVSVYQTAWLQG
    ||   |           ..||||.  ..  | .   .  .     ||.|||  ||  .||.|..    .|. ..  . |.|   |  
evqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 431-586 1.9e-22 74.4 In-house 5-156 (199) alignment 
Range on Protein: 431-586
Range on HMM: 5-156/199.0
EAFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVH-DTAHFGDYEVTMESETARGDFIIRDLKLIS-TKDPSVIRQIRHFHFLH
  .|||||||. |  |.|.|.|.     |||.  ..   .  .| | |...  |...|   || .. |.. |. |  | | . |  |   |.| |. |  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEHGQPWSGQTVLQLVSkveewESEVEKNSHQfDIIGPIVVHCNNGIGRTGVYCALH
| |.  |     |  .|.       || |.  | .   |..||| .| | |||. || 
wkekttpnvalfvgfvva.....srevskkyeq.ekdapvivhcsdgqgftgvfvald
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 432-586 1.9e-22 74.5 In-house 5-155 (198) alignment 
Range on Protein: 432-586
Range on HMM: 5-155/198.0
AFIATQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVH-DTAHFGDYEVTMESETARGDFIIRDLKLIS-TKDPSVIRQIRHFHFLHW
 .|||||||. |  |.|.|.|.     |||.  ..   .  .| | |...  |...|   || .. |.. |. |  | | . |  |   |.| |. |  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PEHGQPWSGQTVLQLVSkveewESEVEKNSHQfDIIGPIVVHCNNGIGRTGVYCALH
 |.  |     |  .|.       || |.  | .   |..||| .| | |||. || 
kekttpnvalfvgfvva.....srevskkyeq.ekdapvivhcsdgqgftgvfvald
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 436-595 1.2e-10 35.3 In-house 96-251 (302) alignment 
Range on Protein: 436-595
Range on HMM: 96-251/302.0
TQHPLQSTTMDYWRMIWQENCRSIVMLLSEKEWDKDVFP-SYLPAVHDTAHFGDYEVTM-------ESETARGDFIIRDLKLISTKD-PSVIRQIRHFHF
   | .||.  .| .| | |   .| | | .| ..  .   |   | .. .|| | |.        |  | . .| .  ...  .|    | . .  ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

LHWPEHGQPWSGQTVLQLVSKVEEWESEVeknshqfdiigpiVVHCNNGIGRTGVYCALHALWQQITQE
  ||.|| |   .| |...   | .  .|             .||| .|.||||   |.    |  ...
sawpdhGapkeaytaldilkfcesykknv.............lvhcsaGvGrtGtlvaikyGiqlcskk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 440-593 3.5e-12 41.0 In-house 36-176 (255) alignment 
Range on Protein: 440-593
Range on HMM: 36-176/255.0
LQSTTM-DYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDT-AHFGDYEVTMESetARGDFIIRDLKLISTKD-PSVIRQIRHFHFLHWPEHGQPW
|.| |.  ....| | .   .|||   .| ...   ||.|  .|    . | .||     .  | ..| |...||       ....|...  |.|.  | 
lysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPe

SGQTVLQLVSKVeeweseveKNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQIT
  . .|...  |        ..|.      ..||||..||||.  .     ..|.. 
lareilnilkvv........rdsk......svvvhCstGiGrsaafvlaelvyqkmi
subfamily_hpo-7_pd Subfamily hpo-7 443-593 4.1e-11 37.3 In-house 46-182 (263) alignment 
Range on Protein: 443-593
Range on HMM: 46-182/263.0
TTMDYWRMIWQENCRSIVMLLSEKEWDKDVFPSYLPAVHDTA-HFGDYEVTMESETArgDFIIRDLKLISTKD-PSVIRQIRHFHFLHWPEHGQPWSGQT
|   ....| | .   .|||   .| ...   ||.|  .|    . . .|.        | ... |.|.|| .    .....|. .  |.|. .|   . 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelare

VLQLVskveewesEVEKNSHqfdiigPIVVHCNNGIGRTGVYCALHALWQQIT
.|...        .| .||.      ..||||..||||.  .     ..|.. 
ilnil........kvarnsk......slvvhcstGiGrsaafsvaElvyqkmi
0048076 (Phosphotyrosine protein) phosphatases II 486-602 4.3e-15 51.1 In-house 13-119 (145) alignment 
Range on Protein: 486-602
Range on HMM: 13-119/145.0
FGDYEVTMESETARGDFIIRD--LkliSTKDPSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEveknshqfDiiGPIVVHCNNGIGRTGVYC
.|.. .... |. .   | .   |   ..  . . |.. ....| || || | . ...|...  .||. .|        .  ||..|||. |.||||...
lgslptaldlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealke........g..gpvlVHCsaGvgRtgtlv

ALHALWQ-QITQEKLVSVYQ
|.. ... ... |. .  ..
aaylmlllgvsleealelvr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 511-591 1.1e-06 22.3 In-house 213-293 (349) alignment 
Range on Protein: 511-591
Range on HMM: 213-293/349.0
STKDPSVIRQIRhfhFLHWPEHGQPWSGQTVLQLV-SKVEEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQ--Q
....| .. |..   .  |.. .     ...|| .  | .  ..   ..  . |   ...|||  | |||||.. |  | .  .
avekPyellqlq...vknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 512-592 3.6e-09 30.8 In-house 211-289 (350) alignment 
Range on Protein: 512-592
Range on HMM: 211-289/350.0
TKDPSVirqIRHFHFLHWPEHGQPWSGQTVLQLVS-KVEEWESEVEKNSHQFDIIGPIVVHCNNGIGRTGVYCALHALWQQI
. || |   . ....  |.. .     . .|| .  | .  .. . ..  . .   ||.|||  |.||||....|  | ...
asdPyv...vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdf
0048179 (Phosphotyrosine protein) phosphatases II 515-599 1.5e-13 46.2 In-house 43-118 (144) alignment 
Range on Protein: 515-599
Range on HMM: 43-118/144.0
PSVIRQIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWeseveknsHQFDiiGPIVVHCNNGIGRTGVYCALHAL-WQQITQEKLVS
....|.. ....| || || | . . .|...  .||.        .. .  ||..|||. |.||||...|.. .  .... |. . 
efleregiqylhlpwpDhgvpdllellleflefieea........leeg..gpvlVHCsaGvgRtgtlvaaylmkklglsleeala
PTPc_DSPc_SM00012 520-611 4.6e-20 67.1 In-house 1-86 (105) alignment 
Range on Protein: 520-611
Range on HMM: 1-86/105.0
QIRHFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKnshqfdiIGPIVVHCNNGIGRTGVYCALHALWQQITQE-KLVSVYQTAWLQGHQR
...|.|.. ||.|| | ... .|.|. .|...... |.        .|.|||| .|.||||...||  |.||...| | |...|. .   .||
tvkhyhytgwpdhgvPeesdsilellravkknknkses.......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqR
0038934 (Phosphotyrosine protein) phosphatases II 523-586 1.6e-06 23.4 In-house 81-136 (194) alignment 
Range on Protein: 523-586
Range on HMM: 81-136/194.0
HFHFLHWPEHGQPWSGQTVLQLVSKVEEWESEVEKNshqfdiigPIVVHCNNGIGRTGVYCALH
... | .|..| . | ...|. .. |.|. .| ...         ..|||  |.||||. .| .
eylklpfpddgtvPsleillrfldlvdeflnedpgg........vvaVHCkaGlgRtGtlvaaY