Gene MINPP1-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily MINPP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP133_AA protein Get Run
NvecP133_AA_0-250 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049226 Phosphoglycerate mutase-like 1-244 1e-37 123.2 In-house 115-340 (342) alignment 
Range on Protein: 1-244
Range on HMM: 115-340/342.0
PKDHDKVLRP-YSMCPRYDQVVDGRNGMLEPRKFAqgSEMQRVISNVKSRLGMPKNaeLNVEVVEKMFMLCAFLTVND-NDTSWCSLFEEEDLNVLeYYL
|...| .|.. |..||..|....    . |  .|   .|.. ........||.. .    ..|.. .. |... .... .  .|||||  |.|..| |.|
pesndtllllpydscpnfdkllkellkseevqlfl..eeildllkklskllglnls..tlsdvadtlydlllyelahglplppwcslftleelkal.yal

DMWQYYEHGYGHEITYKSICPLVAEIAQTIKSFTK-KKIPNGIFRFAHSGGIISLQSILSLYRDPIPltagnyhklsnrtfriarnaPMSSNIAFVLHEC
|...||  |||.||.. ...||. || . ...... .. .  .. ||| . |..| |.| |. | .|                    |..||..| |.||
dllyyygigygeeiarlaggpllneilarleeaiegpsdlklylyfahdttiaallsalglfddqlP....................pyasnlvfElyec

TDGYKVQVLVNERL------TVLPCCkSAVCKLDKFLECYEAIGSNcDLEKMC
...| |.||.|..         || | .  |.||.|.|... .  . | |..|
dgeyyVrvlynggvlslpvtlplpgc.dglcpldefkelvkkflpg.dfeelC
0053031 Phosphoglycerate mutase-like 1-244 1.4e-34 113.0 In-house 115-340 (342) alignment 
Range on Protein: 1-244
Range on HMM: 115-340/342.0
PKDHDKVLRP-YSMCPRYDQVVDGRNGMLEPRKFAQgsEMQRVISNVKSRLGMPKNAELNVeVVEKMFMLCAFLTVNDNDTSWCSLFEEEDLNVLeYYLD
|...| .|.| |..||..|......  . |  .. .  ... ... . ..||.. .  |.. | . . .|.. |...    .||.||  |.| .| |.||
pessdalllpnydpcpafdkllkealaseevkelle..rylellqklskglgltlsdlldl.vsdlydlllyelahglplppwctlftleelkal.yald

MWQYYEHGYGHEITYKSICPLVAEIAQTIKSFTKK-KIPNGIFRFAHSGGIISLQSILSLYRDPIPltagnyhklsnrtfriarnaPMSSNIAFVLHECT
...||  |.|.|... ...||. || . ....... . .  .. ||| . |..| |.| |. | .|                    |..||..| |.|..
llyyyglgpgnelaklaggpllneilarleekisgpldlklylyfahdttiaallsaLglfddqlP....................pyasnlvfElyedp

DGYKVQVLVNER------LTVLPCCKSaVCKLDKFLECYEAIGSNcDLEKMC
..| |.||.|..         || | .  |.|..|.|... .  . | ||.|
geyyVrvlynggtlseplvlplpgcdg.lcplsefkelvkkllpg.dfeklC
subfamily_MINPP1_pd Subfamily MINPP1 2-247 1.8e-91 299.1 In-house 166-417 (420) alignment 
Range on Protein: 2-247
Range on HMM: 166-417/420.0
KDHDKVLRPYSMCPRYDQVVDGRNGMLEPR-KFAQGSEMQRVISNVKSRL-GMPKNAELNVEVVEKMFMLCAF-LTVNDNDTSWCSLFEEEDLNVLEYYL
...||.||....|..|.. |. .. .|. . .|....|.|........|| .. |..||. ...|.||..||. |........||||||...|..|||. 
qesdklLrffdsCkkyknkvkknelnlkeeeefleskelqkaleeiakrlneekklleltekdiedmfeiCayelaikgisnvWcslfekdelleleYle

DMWQYYEHGYGHEITYKSICPLVAEIAQTIKSFTKKKIPNGIFRFAHSGGIISLQSILSLYRDPIPLTAGNYHKLSNRTFRIARNAPMSSNIAFVLHEC-
|...||..|||.||.|.. |||...| ...||....|  .. .||||......|.|.|.||.| ..||| ||||||||.|| .. .|...|.||||..| 
dLknyykegyGyeinysiscpLlndivkllksseeqkqkssslrFaHaetllpllsllGlykDeekLtannyhklsnrkfrssvivpyaanlafvlydCs

TDGYKVQVLVNERLTVLPCCKSAV--CKLDKFLECYEAIGSNCDLEKMCKLD
.|.|||.||.||... |..|....  |.|..|.|.|..| .||||||.|...
kdqykvlvllnekvvkletcsegeifCelqdfkeiykkivdncdleklCevs
0048946 Phosphoglycerate mutase-like 2-250 5.8e-47 153.6 In-house 174-415 (447) alignment 
Range on Protein: 2-250
Range on HMM: 174-415/447.0
KDHDKVLRPysMCPRYDQVVDGRNGmlEPRKFaqgsEMQRVISNVKSRLGmpkNAELNVEVVEKMFMLCAFLTVNDNDTSWCSLFEEEDLNVLEYYLDMW
...| .|.|  .||...... .     |  |.     ...... .|. ||   . .|... |  .. |... |.  . . .|||| .|.|.||||. |..
ssndnlllp..sCpafkellkkela..eelke....llkellerlkkllg...glnltlsdvydlydlllyetaihglsplcslftpeelevleyladle

QYYEHGYGHEITYKSICPLVAEIAQTIKSFTKKKIpNGIFRFAHSGGIISLQSILSLYRDPIPLTAGNYHKlsNRTFRIARNAPMSSNIAFVLHEC----
.|||.|||.|... . .||. || . ... ....    .. ||| . |..| |.| |. | .||.|.|. .  ||.||. .  |..||..| |.||    
fyyeygygdelarlaggpllneilarledaisgds.klylyfaHdttiaallsaLglfddelplpadnlpf..nrlfrsseivPyasnlvfElyecpssl

--TDGYKVQVLVNERLTVLPCCKSA---VCKLDKFLECYEAIgSNcDLEKMCKLDLPN
  ...| |.||.|..   ||.|.|     |.||.|.|... .  . | ||.|.|.|..
psdgeyyVrvlyngeplplpgCgsgpgglCplddFkellkkf.lp.dweklCgltlsv
0047369 Phosphoglycerate mutase-like 2-245 1.5e-41 136.0 In-house 172-437 (438) alignment 
Range on Protein: 2-245
Range on HMM: 172-437/438.0
KDHDKVLR--PYSMCPRYDQVVDGRNGMLEPRKFAqgseMQRVISNVKSRLGMpknAELNVEVVEKMFMLCAFLTVNDND-----TSWCSLFEEEDLNVL
...| .|.  |...||..|......  . |  ..     ...... .|. |.     .|... |  .. |||. |.. ..      ..|||| .|.|.||
esddfllnllpsdscpafdellkeflasdeflell....lkdilkrlkkllpg...lnltpsdvldlydlcaydtlangyaglplspfcslftpeelevl

EYYLDMWQYYEHGYGHEITYKSICPLVAEIAQTIKSFTKKK-----------------IPNGIFRFAHSGGIISLQSILSLYRDPIPLTAGNYHK-LSNR
||. |...||..|||.|... ...||. || . ...  ..|                  .  .. ||| . |..| |.| |. | .||.  .. |   ||
eyladlefyylygygnelaklaggpllneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnr

TFRIARNAPMSSNIAFVLHECT--DGYKVQVLVNERLTVLPCCKSA---VCKLDKFLECYEAIGSNcDLEKMCK
.||. . .|..||..| |.||.  ..| |.||.|..   ||.|.|     |.||.|.|... .  . | |..|.
lfrsseivPyasnlvfElyecpsdgeyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkllpg.dfeelCg
subfamily_ACP2_pd Subfamily ACP2 2-246 1.5e-08 26.6 In-house 125-358 (361) alignment 
Range on Protein: 2-246
Range on HMM: 125-358/361.0
KDHDKVLRPYSMCPRYDQVVDGRNGMlePRKFAQGSEMQRVISNVKSRLGMPKNAELNVEvVEKmFMLCAFLTVNDndTSWCSLFEEEDLNVLEYYLDMW
...|..||. . |||||....  .    |   .  .| . ........ | . . |  .. . .  ..|   . |.   .. .....| .. || . |. 
eeedlllrakknCprydellqeakes..pevkklleenkelleklsestgedidlenfyq.lsd.tlicerkyane..lnlpewandelfekleeladkv

QYYEH----GYGHEITYKSICPLVAEIAQTIKSFTK---KKIPNGIFRF-AHSGGIISLQSILSLYRDPIPLTAgnyhklSNRTFRIARNAPMSSNIAFV
. .|      .  |.   .. ||..|. . .|. .|   ||  . .| . ||   . .| ..|..... .| .|      |   . . ..   . .. ..
keaefglnnektrelkklrgGpllnellenmkeklkceekkkklklflYSaHDttlaalLeaLgifekkappya......saiivElyeeddgkplvkvl

LHECTDGYKVqvlvneRLTVlPCCK-SAVCKLDKFLECYEAIGSNCdLEKMCKL
 .. |.  .       .||. | || .. |.|.|| .... .  .  ....|. 
yrnetskdpp......eltl.pgCkgeedCplskfkkivkpfipdd.vdelCea
His_Phos_2 Histidine phosphatase superfamily (branch 2) 3-208 1.5e-14 46.6 Pfam-A 149-347 (347) alignment 
Range on Protein: 3-208
Range on HMM: 149-347/347.0
DHDKVLRPYSMCPRYDQ-VVDGRNGMLEPRKFaQGSEMQRVIS-NVKSRlgMPKN-AELNVEVVEKMFmLCAFLTVNDNDTSWCSLFEE--EDLNVLEYY
...  .. .. ||.... ..   . . |  ..   ..|.  .. ...    .... ..|  |. ||.|  ..| ... . . ...|...  .|.  ....
lkellregaescpafawppikvekrvvelvnk.lkkvmdenlakrlsal..ctgednllfkerweklf.reffeeekfdiskipelydtmkydalhnrql

LDMWQYYEH-GYGHEITYKSICPLVAEIAQTIKSFTKKKI----PNGIFRFAHSGGIISLQSILSLYRDPIPLtagnyhklsnrtfrIARNAPMSSNIAF
 |. ..|   |.|.|.  |   .|. .... |.| ....        .. |.|   |..| ..| |. .  ..               ... |..|.| |
edleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiare..............aspelpyasqivf

VLHECTDG-YKVQVLVN
 |.|. .  . |..|..
elyedsekkfyvrllfs
His_Phos_2 Histidine phosphatase superfamily (branch 2) 3-208 1.5e-14 46.6 In-house 149-347 (347) alignment 
Range on Protein: 3-208
Range on HMM: 149-347/347.0
DHDKVLRPYSMCPRYDQ-VVDGRNGMLEPRKFaQGSEMQRVIS-NVKSRlgMPKN-AELNVEVVEKMFmLCAFLTVNDNDTSWCSLFEE--EDLNVLEYY
...  .. .. ||.... ..   . . |  ..   ..|.  .. ...    .... ..|  |. ||.|  ..| ... . . ...|...  .|.  ....
lkellregaescpafawppikvekrvvelvnk.lkkvmdenlakrlsal..ctgednllfkerweklf.reffeeekfdiskipelydtmkydalhnrql

LDMWQYYEH-GYGHEITYKSICPLVAEIAQTIKSFTKKKI----PNGIFRFAHSGGIISLQSILSLYRDPIPLtagnyhklsnrtfrIARNAPMSSNIAF
 |. ..|   |.|.|.  |   .|. .... |.| ....        .. |.|   |..| ..| |. .  ..               ... |..|.| |
edleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiare..............aspelpyasqivf

VLHECTDG-YKVQVLVN
 |.|. .  . |..|..
elyedsekkfyvrllfs
0046349 Phosphoglycerate mutase-like 5-246 2.6e-36 118.7 In-house 142-392 (409) alignment 
Range on Protein: 5-246
Range on HMM: 142-392/409.0
DKVLRPYSMCPRYDQVVDGRNGM-LEPRKFA---------QGSEMQRVISNVKSRL-----GMPKNAElnVEVVEKMFMLCAFLTVN-DNDTSWCSLFEE
| .|.|.|.||..|....       |  .|.         . .|...... . .||     |....     .|.. .. .... |..     .||.|| .
dtllppdslcpaldkllkenlkslsevleflvdealldlelldetkdllkklaerlnselpglnltdp..ldvasllydtllyetahglplppwcdlftp

EDLNVLEYYLDMWQYYEHGYGhEITYKSICPLVAEIAQTIKSFTKKKI-------PNGIFRFAHSGGIISLQSILSLyrdpipltagnyhklSNRTFRIA
|.|.||.|. |. .||..|.| |... . .||. || . ... ...|        .  .. ||| . |..| |.| |               ..|.||. 
eelkvlayladleyyylygsg.elaklaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLgl...............fdrlfrss

RNAPMSSNIAFVLHEC--TDGYKVQVLVNERLTVLPCCKSAvCKLDKFLECYEAIGSNC---DLEKMCKL
.  |..||..| |.||  ...| |.||.|..   || |..  |.|..|.|... .  .|   | .|.|.|
dippyasnlvfElyecpsdgeyyVrvlynggplplpgcgeg.cplsefkellkkrlpgcgltdfdklCpl
0049059 Phosphoglycerate mutase-like 6-245 9.6e-40 129.8 In-house 177-435 (435) alignment 
Range on Protein: 6-245
Range on HMM: 177-435/435.0
KVLrPYSMCPRYDQVVDGRNgmleprkfaQGSEMQRV-ISNVKSRLGMPKN-AELNVEVVEKMFMLCAFLTVNDND-----TSWCSLFEEEDLNVLEYYL
  | ||..||..|.....           ...|.. .  ......|    .  .|... |  .. ||.. |.. .       ..|||| ||.|.||||. 
dtl.pydscpafdellkell.........asdeflelflerilkllqellpglgltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyla

DMWQYYEHGYGHEITYKSICPLVAEIAQTIKSFTKKK-----------------IPNGIFRFAHSGGIISLQSILSLYRDPIPLTAGNYHKLS-NRTFRI
|. .||..|||.||.... .||. || . ...  ...                  .  .. ||| . |..| |.| |. | .||.|.|. . . .|.||.
dlefyylygygdeiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrt

ARNAPMSSNIAFVLHECTD--GYKVQVLVNERLTVLPCCKSA---VCKLDKFLECYEAIGSNCDLEKmCK
 . .|..||..| |.|| |  .| |.||.|..   ||.|.|     |.||.|.|... . ...| .. |.
seivPyasnlvfElyecpdgneyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkflpgddfde.Cg
0048439 Phosphoglycerate mutase-like 10-232 1.3e-30 100.0 In-house 131-387 (391) alignment 
Range on Protein: 10-232
Range on HMM: 131-387/391.0
PYSMCPRYDQVVDGRNGMLEPRKFAQgSEMQRVISNVKSRLGMPKNAelnvEVVEKMFMLCAFLTVNDND-----TSWCSLFEEEDLNVLEYYLDMW---
|. .||....    ..    || ... ....|.   ... ||. ..|    | |. .| |||..|.         ...|.||. .|  ..||. ..    
pintcplledlllldalsalprfyls.eilerlaevlnrvlglnlta....edvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpe

----------------------QYYEHGYGhEITYKSICPLVAEIAQTIkSFTKKKIPNGIFRFAHSGGIISLQSILSLYRDPIPLTAGNyhklsnrtfr
                      .|| .|.| ||.. ...||. || . .   . .. |  .. ||| . |..| |.| |. |..||.|..          
wltdellspellkqladlvnelyyyltgsg.eiaklaggpllneilddl.vangpsdpklylyfaHdttiaallsaLglfndtlplpadl..........

iarnAPMSSNIAFVLHEC--TDGYKVQVLVNER--------------------LTVLPCCKSA---VCKLDKFLECYE
     |..||..| |.||  ...| |.||.|..                    . .|| |.|     |.||.|.|...
....ppyasnlvfElyecpsdgeyyVrvlynggtldlprdltlldldefllrlvlplpgcgsgpgglCplddFvelvk