Gene MINPP1-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily MINPP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP133_AA protein Get Run
NvecP133_AA_0-250 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049226 Phosphoglycerate mutase-like 1-244 1e-37 123.2 In-house 115-340 (342) alignment
Range on Protein: 1-244
Range on HMM: 115-340/342.0
PKDHDKVLRP-YSMCPRYDQVVDGRNGMLEPRKFAqgSEMQRVISNVKSRLGMPKNaeLNVEVVEKMFMLCAFLTVND-NDTSWCSLFEEEDLNVLeYYL
|...| .|.. |..||..|....    . |  .|   .|.. ........||.. .    ..|.. .. |... .... .  .|||||  |.|..| |.|
pesndtllllpydscpnfdkllkellkseevqlfl..eeildllkklskllglnls..tlsdvadtlydlllyelahglplppwcslftleelkal.yal

DMWQYYEHGYGHEITYKSICPLVAEIAQTIKSFTK-KKIPNGIFRFAHSGGIISLQSILSLYRDPIPltagnyhklsnrtfriarnaPMSSNIAFVLHEC
|...||  |||.||.. ...||. || . ...... .. .  .. ||| . |..| |.| |. | .|                    |..||..| |.||
dllyyygigygeeiarlaggpllneilarleeaiegpsdlklylyfahdttiaallsalglfddqlP....................pyasnlvfElyec

TDGYKVQVLVNERL------TVLPCCkSAVCKLDKFLECYEAIGSNcDLEKMC
...| |.||.|..         || | .  |.||.|.|... .  . | |..|
dgeyyVrvlynggvlslpvtlplpgc.dglcpldefkelvkkflpg.dfeelC

0053031 Phosphoglycerate mutase-like 1-244 1.4e-34 113.0 In-house 115-340 (342) alignment
Range on Protein: 1-244
Range on HMM: 115-340/342.0
PKDHDKVLRP-YSMCPRYDQVVDGRNGMLEPRKFAQgsEMQRVISNVKSRLGMPKNAELNVeVVEKMFMLCAFLTVNDNDTSWCSLFEEEDLNVLeYYLD
|...| .|.| |..||..|......  . |  .. .  ... ... . ..||.. .  |.. | . . .|.. |...    .||.||  |.| .| |.||
pessdalllpnydpcpafdkllkealaseevkelle..rylellqklskglgltlsdlldl.vsdlydlllyelahglplppwctlftleelkal.yald

MWQYYEHGYGHEITYKSICPLVAEIAQTIKSFTKK-KIPNGIFRFAHSGGIISLQSILSLYRDPIPltagnyhklsnrtfriarnaPMSSNIAFVLHECT
...||  |.|.|... ...||. || . ....... . .  .. ||| . |..| |.| |. | .|                    |..||..| |.|..
llyyyglgpgnelaklaggpllneilarleekisgpldlklylyfahdttiaallsaLglfddqlP....................pyasnlvfElyedp

DGYKVQVLVNER------LTVLPCCKSaVCKLDKFLECYEAIGSNcDLEKMC
..| |.||.|..         || | .  |.|..|.|... .  . | ||.|
geyyVrvlynggtlseplvlplpgcdg.lcplsefkelvkkllpg.dfeklC

subfamily_MINPP1_pd Subfamily MINPP1 2-247 1.8e-91 299.1 In-house 166-417 (420) alignment
Range on Protein: 2-247
Range on HMM: 166-417/420.0
KDHDKVLRPYSMCPRYDQVVDGRNGMLEPR-KFAQGSEMQRVISNVKSRL-GMPKNAELNVEVVEKMFMLCAF-LTVNDNDTSWCSLFEEEDLNVLEYYL
...||.||....|..|.. |. .. .|. . .|....|.|........|| .. |..||. ...|.||..||. |........||||||...|..|||. 
qesdklLrffdsCkkyknkvkknelnlkeeeefleskelqkaleeiakrlneekklleltekdiedmfeiCayelaikgisnvWcslfekdelleleYle

DMWQYYEHGYGHEITYKSICPLVAEIAQTIKSFTKKKIPNGIFRFAHSGGIISLQSILSLYRDPIPLTAGNYHKLSNRTFRIARNAPMSSNIAFVLHEC-
|...||..|||.||.|.. |||...| ...||....|  .. .||||......|.|.|.||.| ..||| ||||||||.|| .. .|...|.||||..| 
dLknyykegyGyeinysiscpLlndivkllksseeqkqkssslrFaHaetllpllsllGlykDeekLtannyhklsnrkfrssvivpyaanlafvlydCs

TDGYKVQVLVNERLTVLPCCKSAV--CKLDKFLECYEAIGSNCDLEKMCKLD
.|.|||.||.||... |..|....  |.|..|.|.|..| .||||||.|...
kdqykvlvllnekvvkletcsegeifCelqdfkeiykkivdncdleklCevs

0048946 Phosphoglycerate mutase-like 2-250 5.8e-47 153.6 In-house 174-415 (447) alignment
Range on Protein: 2-250
Range on HMM: 174-415/447.0
KDHDKVLRPysMCPRYDQVVDGRNGmlEPRKFaqgsEMQRVISNVKSRLGmpkNAELNVEVVEKMFMLCAFLTVNDNDTSWCSLFEEEDLNVLEYYLDMW
...| .|.|  .||...... .     |  |.     ...... .|. ||   . .|... |  .. |... |.  . . .|||| .|.|.||||. |..
ssndnlllp..sCpafkellkkela..eelke....llkellerlkkllg...glnltlsdvydlydlllyetaihglsplcslftpeelevleyladle

QYYEHGYGHEITYKSICPLVAEIAQTIKSFTKKKIpNGIFRFAHSGGIISLQSILSLYRDPIPLTAGNYHKlsNRTFRIARNAPMSSNIAFVLHEC----
.|||.|||.|... . .||. || . ... ....    .. ||| . |..| |.| |. | .||.|.|. .  ||.||. .  |..||..| |.||    
fyyeygygdelarlaggpllneilarledaisgds.klylyfaHdttiaallsaLglfddelplpadnlpf..nrlfrsseivPyasnlvfElyecpssl

--TDGYKVQVLVNERLTVLPCCKSA---VCKLDKFLECYEAIgSNcDLEKMCKLDLPN
  ...| |.||.|..   ||.|.|     |.||.|.|... .  . | ||.|.|.|..
psdgeyyVrvlyngeplplpgCgsgpgglCplddFkellkkf.lp.dweklCgltlsv

0047369 Phosphoglycerate mutase-like 2-245 1.5e-41 136.0 In-house 172-437 (438) alignment
Range on Protein: 2-245
Range on HMM: 172-437/438.0
KDHDKVLR--PYSMCPRYDQVVDGRNGMLEPRKFAqgseMQRVISNVKSRLGMpknAELNVEVVEKMFMLCAFLTVNDND-----TSWCSLFEEEDLNVL
...| .|.  |...||..|......  . |  ..     ...... .|. |.     .|... |  .. |||. |.. ..      ..|||| .|.|.||
esddfllnllpsdscpafdellkeflasdeflell....lkdilkrlkkllpg...lnltpsdvldlydlcaydtlangyaglplspfcslftpeelevl

EYYLDMWQYYEHGYGHEITYKSICPLVAEIAQTIKSFTKKK-----------------IPNGIFRFAHSGGIISLQSILSLYRDPIPLTAGNYHK-LSNR
||. |...||..|||.|... ...||. || . ...  ..|                  .  .. ||| . |..| |.| |. | .||.  .. |   ||
eyladlefyylygygnelaklaggpllneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnr

TFRIARNAPMSSNIAFVLHECT--DGYKVQVLVNERLTVLPCCKSA---VCKLDKFLECYEAIGSNcDLEKMCK
.||. . .|..||..| |.||.  ..| |.||.|..   ||.|.|     |.||.|.|... .  . | |..|.
lfrsseivPyasnlvfElyecpsdgeyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkllpg.dfeelCg

subfamily_ACP2_pd Subfamily ACP2 2-246 1.5e-08 26.6 In-house 125-358 (361) alignment
Range on Protein: 2-246
Range on HMM: 125-358/361.0
KDHDKVLRPYSMCPRYDQVVDGRNGMlePRKFAQGSEMQRVISNVKSRLGMPKNAELNVEvVEKmFMLCAFLTVNDndTSWCSLFEEEDLNVLEYYLDMW
...|..||. . |||||....  .    |   .  .| . ........ | . . |  .. . .  ..|   . |.   .. .....| .. || . |. 
eeedlllrakknCprydellqeakes..pevkklleenkelleklsestgedidlenfyq.lsd.tlicerkyane..lnlpewandelfekleeladkv

QYYEH----GYGHEITYKSICPLVAEIAQTIKSFTK---KKIPNGIFRF-AHSGGIISLQSILSLYRDPIPLTAgnyhklSNRTFRIARNAPMSSNIAFV
. .|      .  |.   .. ||..|. . .|. .|   ||  . .| . ||   . .| ..|..... .| .|      |   . . ..   . .. ..
keaefglnnektrelkklrgGpllnellenmkeklkceekkkklklflYSaHDttlaalLeaLgifekkappya......saiivElyeeddgkplvkvl

LHECTDGYKVqvlvneRLTVlPCCK-SAVCKLDKFLECYEAIGSNCdLEKMCKL
 .. |.  .       .||. | || .. |.|.|| .... .  .  ....|. 
yrnetskdpp......eltl.pgCkgeedCplskfkkivkpfipdd.vdelCea

His_Phos_2 Histidine phosphatase superfamily (branch 2) 3-208 1.5e-14 46.6 Pfam-A 149-347 (347) alignment
Range on Protein: 3-208
Range on HMM: 149-347/347.0
DHDKVLRPYSMCPRYDQ-VVDGRNGMLEPRKFaQGSEMQRVIS-NVKSRlgMPKN-AELNVEVVEKMFmLCAFLTVNDNDTSWCSLFEE--EDLNVLEYY
...  .. .. ||.... ..   . . |  ..   ..|.  .. ...    .... ..|  |. ||.|  ..| ... . . ...|...  .|.  ....
lkellregaescpafawppikvekrvvelvnk.lkkvmdenlakrlsal..ctgednllfkerweklf.reffeeekfdiskipelydtmkydalhnrql

LDMWQYYEH-GYGHEITYKSICPLVAEIAQTIKSFTKKKI----PNGIFRFAHSGGIISLQSILSLYRDPIPLtagnyhklsnrtfrIARNAPMSSNIAF
 |. ..|   |.|.|.  |   .|. .... |.| ....        .. |.|   |..| ..| |. .  ..               ... |..|.| |
edleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiare..............aspelpyasqivf

VLHECTDG-YKVQVLVN
 |.|. .  . |..|..
elyedsekkfyvrllfs

His_Phos_2 Histidine phosphatase superfamily (branch 2) 3-208 1.5e-14 46.6 In-house 149-347 (347) alignment
Range on Protein: 3-208
Range on HMM: 149-347/347.0
DHDKVLRPYSMCPRYDQ-VVDGRNGMLEPRKFaQGSEMQRVIS-NVKSRlgMPKN-AELNVEVVEKMFmLCAFLTVNDNDTSWCSLFEE--EDLNVLEYY
...  .. .. ||.... ..   . . |  ..   ..|.  .. ...    .... ..|  |. ||.|  ..| ... . . ...|...  .|.  ....
lkellregaescpafawppikvekrvvelvnk.lkkvmdenlakrlsal..ctgednllfkerweklf.reffeeekfdiskipelydtmkydalhnrql

LDMWQYYEH-GYGHEITYKSICPLVAEIAQTIKSFTKKKI----PNGIFRFAHSGGIISLQSILSLYRDPIPLtagnyhklsnrtfrIARNAPMSSNIAF
 |. ..|   |.|.|.  |   .|. .... |.| ....        .. |.|   |..| ..| |. .  ..               ... |..|.| |
edleelyklygigdeeklkigllllnpllkkilsdleetqpsrhaklrlyfthDshiytllnaLgleekiare..............aspelpyasqivf

VLHECTDG-YKVQVLVN
 |.|. .  . |..|..
elyedsekkfyvrllfs

0046349 Phosphoglycerate mutase-like 5-246 2.6e-36 118.7 In-house 142-392 (409) alignment
Range on Protein: 5-246
Range on HMM: 142-392/409.0
DKVLRPYSMCPRYDQVVDGRNGM-LEPRKFA---------QGSEMQRVISNVKSRL-----GMPKNAElnVEVVEKMFMLCAFLTVN-DNDTSWCSLFEE
| .|.|.|.||..|....       |  .|.         . .|...... . .||     |....     .|.. .. .... |..     .||.|| .
dtllppdslcpaldkllkenlkslsevleflvdealldlelldetkdllkklaerlnselpglnltdp..ldvasllydtllyetahglplppwcdlftp

EDLNVLEYYLDMWQYYEHGYGhEITYKSICPLVAEIAQTIKSFTKKKI-------PNGIFRFAHSGGIISLQSILSLyrdpipltagnyhklSNRTFRIA
|.|.||.|. |. .||..|.| |... . .||. || . ... ...|        .  .. ||| . |..| |.| |               ..|.||. 
eelkvlayladleyyylygsg.elaklaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLgl...............fdrlfrss

RNAPMSSNIAFVLHEC--TDGYKVQVLVNERLTVLPCCKSAvCKLDKFLECYEAIGSNC---DLEKMCKL
.  |..||..| |.||  ...| |.||.|..   || |..  |.|..|.|... .  .|   | .|.|.|
dippyasnlvfElyecpsdgeyyVrvlynggplplpgcgeg.cplsefkellkkrlpgcgltdfdklCpl

0049059 Phosphoglycerate mutase-like 6-245 9.6e-40 129.8 In-house 177-435 (435) alignment
Range on Protein: 6-245
Range on HMM: 177-435/435.0
KVLrPYSMCPRYDQVVDGRNgmleprkfaQGSEMQRV-ISNVKSRLGMPKN-AELNVEVVEKMFMLCAFLTVNDND-----TSWCSLFEEEDLNVLEYYL
  | ||..||..|.....           ...|.. .  ......|    .  .|... |  .. ||.. |.. .       ..|||| ||.|.||||. 
dtl.pydscpafdellkell.........asdeflelflerilkllqellpglgltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyla

DMWQYYEHGYGHEITYKSICPLVAEIAQTIKSFTKKK-----------------IPNGIFRFAHSGGIISLQSILSLYRDPIPLTAGNYHKLS-NRTFRI
|. .||..|||.||.... .||. || . ...  ...                  .  .. ||| . |..| |.| |. | .||.|.|. . . .|.||.
dlefyylygygdeiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrt

ARNAPMSSNIAFVLHECTD--GYKVQVLVNERLTVLPCCKSA---VCKLDKFLECYEAIGSNCDLEKmCK
 . .|..||..| |.|| |  .| |.||.|..   ||.|.|     |.||.|.|... . ...| .. |.
seivPyasnlvfElyecpdgneyyVrvlyngkvlplpgcgsgpgglCplddFkelvkkflpgddfde.Cg

0048439 Phosphoglycerate mutase-like 10-232 1.3e-30 100.0 In-house 131-387 (391) alignment
Range on Protein: 10-232
Range on HMM: 131-387/391.0
PYSMCPRYDQVVDGRNGMLEPRKFAQgSEMQRVISNVKSRLGMPKNAelnvEVVEKMFMLCAFLTVNDND-----TSWCSLFEEEDLNVLEYYLDMW---
|. .||....    ..    || ... ....|.   ... ||. ..|    | |. .| |||..|.         ...|.||. .|  ..||. ..    
pintcplledlllldalsalprfyls.eilerlaevlnrvlglnlta....edvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpe

----------------------QYYEHGYGhEITYKSICPLVAEIAQTIkSFTKKKIPNGIFRFAHSGGIISLQSILSLYRDPIPLTAGNyhklsnrtfr
                      .|| .|.| ||.. ...||. || . .   . .. |  .. ||| . |..| |.| |. |..||.|..          
wltdellspellkqladlvnelyyyltgsg.eiaklaggpllneilddl.vangpsdpklylyfaHdttiaallsaLglfndtlplpadl..........

iarnAPMSSNIAFVLHEC--TDGYKVQVLVNER--------------------LTVLPCCKSA---VCKLDKFLECYE
     |..||..| |.||  ...| |.||.|..                    . .|| |.|     |.||.|.|...
....ppyasnlvfElyecpsdgeyyVrvlynggtldlprdltlldldefllrlvlplpgcgsgpgglCplddFvelvk