Gene PTP1 in Saccharomyces cerevisiae

Synonym: YDL230W, PTP1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Fungi-PTP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP015_AA protein Get Run
ScerP015_AA_33-329 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRK_pd Subfamily PTPRK 14-325 2.3e-38 126.8 In-house 8-273 (314) alignment 
Range on Protein: 14-325
Range on HMM: 8-273/314.0
DLLGKFKFIQNQEDGRLREATNGTVNSrWSlgVSIEPRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVkvnvpGQSIEPGYYIATQGPTRKTW
||| . . ..  |   ..|  .  ..  |   .. .  | ..||. .|..|.| || |.|. |.   |||||...          |  .|.|||| ..| 
dllqsiallkraegygfkeeyeslfeg.wd..aakkdenreknrsgdilaydrsrvflitidgdpssdyinaali.....dsykrpaafivtqgPlqetv

DQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPrggvddtvriaskwespgganDMTQFPSDLKIEFVNVHKVKDYYTVTdIKLTPTDPLVGPVKT
  ||.. |..   .   |||.| |||  | ||..|||                     . |.   |.|.|.|...  ... . .  ... .   .  ...
kdfWrlvyde...ncasivmltelvevgrvkClkyWP.....................edtevygdikvelvetellaelvvri.frveklargqeeire

VHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRG-NPIIVHCSAGVGRTGTFIALDHLMhDTLDFKNITErsrhsdrateeytrdlIEQIVLQLRSQRM
|..| |  | | . | .   ...| .. .. .  .  .|.|||||| ||||||||.| .. | .. ... .                . ..| .|||...
vrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl.dmieregvvd................vfnavktlrsrkv

KMVQTKDQFLFIYHAA
 ||.|..|. ||| ..
nmveteeqykfiydvi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 22-333 1.1e-131 433.8 In-house 6-348 (350) alignment 
Range on Protein: 22-333
Range on HMM: 6-348/350.0
IQNQEDGRLREATNGTVNSRWSLGVSIE-PRND----------ARNRYVNIMPYERNRVHLK-----------TLSGNDYINASYVKVNVPGQSIEPGY-
.| ..  .|  . |.||.||.||....| |.||          |.|||.||.|||..||.||           .||.||||||.|.|.......|.|.. 
vqkrsklkliitknstvksrlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfk

YIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRGGVDD-TVRIASKWESPGGANDMTQFPSDLKIEFV------NVHKVKDYY
|||||.|...|.|.|......|   ...||...|..||.|.||||.||..|..|| ||..|||||...|.||......|.|.|..      .....||..
YiatqaPlpstvddfykvilln...kvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnn

TVTDIKLTPTDPLVgpvktVHHFYFDLWKDM---NKPEEVVPIME--------LCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITE
..|.|.|...||.|     |.......|||.   ..||......|        |.|.||. |.|..||.||||||||||||...||.|..|.....|.|.
sltaitlaasdPyv.....vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltk

RSRHSDRATEeyTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYLNSLSV
.||..|.|..  |||||..||..||.||..|||..|||.|||.|......|. 
esrkldvaak..trDlisiivnelrkqrismvqnldqfifiYeallfyfaLrk
0049772 (Phosphotyrosine protein) phosphatases II 34-327 3.7e-31 104.4 In-house 28-278 (314) alignment 
Range on Protein: 34-327
Range on HMM: 28-278/314.0
TNGTVNSRWSLGVSIEPRNDARNRYVNIMPYErNRVHLKTL--SGNDYINASYVKVNvpgqsiepGYYIATQGPTRKTWDQF----------WQMCYHNc
....| ..... |.  ..|  .||| .|.|.. |||.|..|  || ||||||||.            .||||||.  |.. |          |.|  .. 
rslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf........lkfIatqgpleitvvdfreepvlyyngwrmvlrg.

PLDNIVIVM---------------------VTPLVEYNrekcyqywprggvddtvriaskwespggandmtQFPSDLKIEFVNvhkvkdyytvtdiklTP
 |. ..|||                      ..| ...                                  .|.   .|. .               . 
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng.................................neptaadlellk...............ee

TDPLVGPVKTVHHFYFDLWKDmNKPEEVVPIMELCAHSHSLnSRGNPIIVHCSAGVGRTGTFIALDHLMHDTlDfknitersrhsdrateeytrDLIEQI
...   . ... ...   . | . .     . |.... ... ..|.|..|||.||.||||||.... ||.   .                      .|..
lydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll.g....................vsleea

VLQLRSQRM-----KMVQTKDQFLFIYHAAKY
. ..|..|.      .... .|..||..| ..
ledvrlkRpinpnpgfieqleqyefilealle
0046845 (Phosphotyrosine protein) phosphatases II 37-328 6.3e-70 231.1 In-house 13-273 (284) alignment 
Range on Protein: 37-328
Range on HMM: 13-273/284.0
TVNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG----NDYINASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVT
||.  .|| |.. | |  .|||..|.||...||.||.|.|    .||||||||..   . .. .  .||||||. .|.. ||.|....   .  ||||.|
tvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq...nvrvIVmlt

PLVEYNREKCYQYWPRGgvDDTVRIaskwespggandmtqfpSDLKIEFVNVHKvKDYYTVTDIKLTPTdPLVGPVKTVHHFYFDLWKDMNKPEEVVPIM
.|||..||||.||||    ......                  |.......... ||.|||. ..||..  . |...||.||..  | |.. |... ...
elvengrekcaqYwple..gevlty.................gdftvtllseev.kddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedll

ELCAHSHSLNSR---GNPIIVHCSAGVGRTGTFIALDHLMHDTLDFK---NITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
|..   ..|...   |.||.|||||||||||||||||.|..     .   ...                 ....| .||.||. |||| .|..|.|.|. 
eflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvd.................vleavkrlreqRpgmvqtleqyrfvyeall

YL
..
ey
subfamily_PTPRG_pd Subfamily PTPRG 37-324 2.8e-46 152.9 In-house 32-282 (563) alignment 
Range on Protein: 37-324
Range on HMM: 32-282/563.0
TVNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---N-DYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVT
|...      | .| |  .|||.||..|.| ||.|. |.|   . |||||.|..    ..      .|||||| ..| | ||.| . .      .|||.|
tiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkska.....fiatqgplkdtfddFWrmiWeq...nvaiivmit

PLVEYNREKCYQYWPRGGVDDTVRIASKWESPGGANDMTQFpsdlkiefvnvhkvkdYYTVTDIKLTPTDPlVGPVKTVHHFYFDLWKDMNKPEEVVPIM
 ||| .|.|| .|||. .. .   .  . ..       |.                   .. ..||  ..     .|.| .. .  | |.. ||  .| .
nlvergrrkcdvYWPkdesetygalqvtlieeevlalytvr................tlviknlklkkkkq.cdteklvrqyhytkWPdhgvPehslpvL

ELCAHSHSLNSR-GNPIIVHCSAGVGRTGTFIALDHLMHDtLDFKNITErsrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
    .|   | .   ||.||||||||||||.|.|| |... .  .|. .                . ... ..|.||  .|||..|..|.. |
ifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkq.iqqenavn................vfgflkhiraqRnflvqteEqYiflhda
0045450 (Phosphotyrosine protein) phosphatases II 38-328 4.7e-64 212.4 In-house 41-303 (307) alignment 
Range on Protein: 38-328
Range on HMM: 41-303/307.0
VNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG----NDYINASYVKVNVP---GQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVM
|   ..  ..  | |  .|||..|.||...||.|..|.|    .||||||||.|...   .  . .  .||||||. .|.. ||.|....   .  ||||
vfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweq...gvtvivm

VTPLVEYNREKCYQYWPRGGVDDTVRiaskwespggandmtqfpsDLKIEFVNVHKvKDYYTVTDIKLTPTdPLVGPVKTVHHFYFDLWKDMNKP---EE
.|.|||..||||.||||  |   | .                   ........... .|.|||. ...|..    |.. ||.||..  | |.. |   ||
ltelvelgrekcaqywPdegeeltyg...................nftvtllseeh.ldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfee

VVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKN---ITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.. ..|.. . .. ...|.|..|||||||||||||||.. ...   . .    ..                 ....| .||.||...||. .|. |.|.|
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd.................lleavkllreqRpgavqnpeqyrflyea

AKYL
...|
llel
subfamily_PTPRB_pd Subfamily PTPRB 38-324 8.5e-58 190.7 In-house 37-280 (293) alignment 
Range on Protein: 38-324
Range on HMM: 37-280/293.0
VNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHL---KTLSGNDYINASYVkvnvPGQSIePGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPL
|..  .  .. ...|.|.||| ||.||. .||.|   |. ||.|||||.|.    ||..  |  .||||||  .| |.||.|.. .      .|||.| |
vgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi....pgyns.prefiatqGPlpetvddfWrmvwek...kssiivmltql

VEYNREKCYQYWPRGgvddtvriaskwespgganDMTQFPSDLKIEFVNVHKVKDyYTVTDIKLTPtdplVGPVKTVHHFYFDLWKDMNKPEEVVPIMEL
||  ..|| .|||.                    . ...  |.|...|. ....| ... ..|..         ..|... |  | | . ||.  .....
vekgkvkCeeYWPad...................eepvlyGdikvtlvaeeeled.wvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldf

CAHSHSL---NSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDfknitersrhsdratEEYTrDlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
. . ..    ... .||.|||||||||||||||||.|...  .               |.|  | |  || .||..|. .|||..|..||...
vrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee...............edyv.d.ifgivaelReeRnllvqtekqYifihqc
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 38-150 6.9e-29 95.8 In-house 33-140 (288) alignment 
Range on Protein: 38-150
Range on HMM: 33-140/288.0
VNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKT---LSGNDYINASYVKVNVPGQsiepgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPL
...  |  .. ...|. .||| ||.||. .||.||     .|.|||||||....   .      |||||||  .| ..||.. | |   .   |||.| |
lektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkk.....kyiatqgPladtvndfWelvyen...ktstivmltel

VEYNREKCYQYWPRGG
|| ...|| .||| ..
veggktkCeeYWPdad
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 39-324 1.5e-40 133.9 In-house 33-278 (290) alignment 
Range on Protein: 39-324
Range on HMM: 33-278/290.0
NSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSGN-----DYINASYVKvnvpgQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTP
.|  .  | . . |  .||. ||..|. ||. |. .||.     .||||.|.|     .  |   |||||||. .|  .||.. ...   .  .|||.| 
esehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik.....gykekkqyiatqgpvsntlvdFWkliwqe...kvtiivmltn

LVEYNREKCYQYWPRGGVDDTVRIASKWespggandmtqfpsdlkiefvNVHKVKDYYTVTDIKLTPTDPLvGPVKTVHHFYFDLWKDMNKPEEVVPIME
 .| ...||.||||  ....   .  |                      .  .. ..|. . .... ..   |. ..|... .  |..  | ..   |. 
iieegkvkCqqYWpdsdtkaygefsikl.....................lneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtill

LCAHSHS--LNSRGNPIIVHCSAGVGRTGTFIALDHlmhdTLdfknitersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHA
. ..       .  ..|.||||..|||...|.|..     |.            ...  |   |.. |.. ..|.|....|||..|. .|.. 
vieemyktqrkrgntsivvHCSdtvgrsavfcaaat....ti............nkcktegvidvf.qvlksqRiqkpgsvqtvqqyqgifqi
DSPc_SM00195 40-326 9.1e-72 236.9 In-house 16-259 (263) alignment 
Range on Protein: 40-326
Range on HMM: 16-259/263.0
SrwSLGVSIEPRNDARNRYVNIMPYERNRVHLKTL---SGNDYINASYVKVNvpgqsIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVE
.  .   .....| ..||| ||.||...||.||.    .|.|||||.|.|..      ..  |||||||. .|...||.|....   .  .|||.|  .|
k..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.....nkkkkyIatQgPlpstvedFWrmvwee...kvkiivmlteeee

YNREKCYQYWPRGGvddtvriaskwespggaNDMTQFPsDLKIEFVNVHKVKDYYTVTDIKLTPTDPlvGPVKTVHHFYFDLWKDMNKPEEV---VPIME
 ..|||..|||.                   .. ..|  ......|.|.|.|| .......|| ...     ..|... .  |.| . |..    . ...
ngkekcdrywpees.................ggketfg.kisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellr

LCAHSHSLNsrGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNitersrhsdrateeytrDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
 . .|.| .   .||.|||||||||||||...| ...   . |.                 . |..|| .||.||..||||..|.||||.|. 
avkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekk.................vdifeivkelRkqRpgmvqtleqYlfiyeail
PTPc_SM00194 40-326 9.1e-72 236.9 In-house 16-259 (263) alignment 
Range on Protein: 40-326
Range on HMM: 16-259/263.0
SrwSLGVSIEPRNDARNRYVNIMPYERNRVHLKTL---SGNDYINASYVKVNvpgqsIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVE
.  .   .....| ..||| ||.||...||.||.    .|.|||||.|.|..      ..  |||||||. .|...||.|....   .  .|||.|  .|
k..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.....nkkkkyIatQgPlpstvedFWrmvwee...kvkiivmlteeee

YNREKCYQYWPRGGvddtvriaskwespggaNDMTQFPsDLKIEFVNVHKVKDYYTVTDIKLTPTDPlvGPVKTVHHFYFDLWKDMNKPEEV---VPIME
 ..|||..|||.                   .. ..|  ......|.|.|.|| .......|| ...     ..|... .  |.| . |..    . ...
ngkekcdrywpees.................ggketfg.kisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellr

LCAHSHSLNsrGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNitersrhsdrateeytrDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
 . .|.| .   .||.|||||||||||||...| ...   . |.                 . |..|| .||.||..||||..|.||||.|. 
avkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekk.................vdifeivkelRkqRpgmvqtleqYlfiyeail
0040438 (Phosphotyrosine protein) phosphatases II 42-328 2.8e-64 212.7 In-house 33-275 (317) alignment 
Range on Protein: 42-328
Range on HMM: 33-275/317.0
WSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVkvNVPGQSIEpgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYN
..  |.. | |  .|||..|.||...||.|. |.|   .||||||||  ..| .. .   .||||||. .|.. ||.|....   .  ||||.|.|.|..
dtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrk...fIatqgPlpntvedFwrmvweq...gvtvivmLteleelg

REKCYQYWPRggvDDTVRIAskwespggandmtqfpsDLKIEFVNVHKvKDYYTVTDIKLTPTdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHS
||||.||||    ..|. .                  |.......... ....|.. ......    ... ||.||..  | |.. |.   .. ...   
rekcaqYwpl...getltyg.................dftvtllseee.lagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfleav

HSLNSR-GNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
.. ... |.|..|||||||||||||||.. ...     ....                 .|..| .||.||...||| .|. |.| |. ..
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.................veeavkelreqRpgavqtpeqyrflydalley
subfamily_PTPN12_pd Subfamily PTPN12 42-326 1.1e-45 150.8 In-house 30-274 (290) alignment 
Range on Protein: 42-326
Range on HMM: 30-274/290.0
WSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKVnvPGqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYN
.|  .. ...| ..||| .|.||. .||.|.. ...   |||||...|   .    ..  |||.|||  || |.||.| ..    .  ..||.  .|| .
ysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg..ve...gkleyiaaqgPLpktlddfWrmiwek...nveivvmaCrevelg

REKCYQYWPRGGvddtvriaskwespggaNDMTQFpSDLKIEFVNVHKVKDYYTVTDIKLTPTdplvGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHS
. || .|||  |                 .. ..| ......  . ..|.| ...  .|..      .  ..|. | .  | | . |. . ...|| .. 
kkkCerYWpeeg.................eeelef.gefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielv

HSLNS-RGNPIIVHCSAGVGRTGTFIALDHLMhDTLDFKNITERSRhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
..|..   .|..|||||||||||| ||.|.   . |  ..|.|.               . ..||.|| ||  .||||.|. ..|.|  
relqesedaPlvvhCsaGvGrtGtiiaidyvr.ellkaekipeeld.............vfdlvlelrkqraalvqtkeqyelvykava
subfamily_PTPN1_pd Subfamily PTPN1 42-324 6.5e-44 144.8 In-house 22-266 (290) alignment 
Range on Protein: 42-324
Range on HMM: 22-266/290.0
WSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSgNDYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREK
..  .. .|.| ..||| .. ||.  |..|.  . ||||||| |...   .|     || ||||  .| | |||| ...   .   .||.  .|| .. |
fptreaklpenrnlnryrdvspydhsriklerad.ndyinaslveleeakrs.....yiltqGPlpntvdhfWqmvWeq...kskavvmlnkvvekeqik

CYQYWPRGGVddtvriaskwespggANDMTQFPSDLKIEFVNVhKVKDYYTVTDIKLTptDPLVGPVKTVHHFYFDLWKDMNKPEE---VVPIMELCAHS
|.||||.|                  . ..   . ||.....  ..|.||||  ..|.  .      ... ||..  | |.  ||     .  .  . .|
caqywPqgee...............ekellledtklkvklise.erksyytvrllele..nlktqetreilhfhyttwpdfgvpespaaflkflfkvres

HSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDtldfknITERsrhSDRAT-EeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
 ||.|   | ..|||||.||.|||. .| ..        | ..    | .. .      |.. .|.||..|. ..||.||. | | |
GslssdvGpavihcsaGiGrsGtfclvdtclvl......iekk...ddlssvd......ikkvllelrkyrlGliqtadqlrfsyla
0051299 (Phosphotyrosine protein) phosphatases II 43-327 9.3e-67 220.8 In-house 40-284 (288) alignment 
Range on Protein: 43-327
Range on HMM: 40-284/288.0
SLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKVnvpgqSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNR
.| ... | |  .|||..|.||...||.|..|.|   .|||||||...        .  .||||||. .|.. ||.|....   .  ||||.|.|||..|
tlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg.....ynlkrkfIatqgPlpntvedFWrmvweq...nvrvIvmltklvelgr

EKCYQYWPRggvDDTVRIaskwespggandmtqfpSDLKIEFVNVHKvKDYYTVTDIKLTPTDP--LVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAH
|||.||||    .... .                  |.......... .|.|||. ...|..|     | ..||.||..  | |.. |. . ...... .
ekcaqYwpl...ggslty.................gditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

SHSL-NSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
 ..  .|.|.|..|||||||||||||||||.|..  .  . ..                 ....| .||.||. |||| .|..|.|.|. .
vrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd.................vleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_PTPRD_pd Subfamily PTPRD 43-325 7e-55 181.7 In-house 39-277 (564) alignment 
Range on Protein: 43-325
Range on HMM: 39-277/564.0
SLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNR
.  .. .| | |.||| ||..|...|| |... |    ||||||...    |   ..  |||||||. .| . ||.|.. .   .  .|||.| |.| ..
tweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyr.krkayIAtqgPlaetiedFWRmvweq...nsstiVmltkleEkgk

EKCYQYWPRGGVDDTVRIASKWESPGGANDMTQfpSDLKI---EfvnvhkvkdyytvtdikltptdplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCA
.|| .|||  |     ..  . |.    .|..    ..|.   .                           ...|..|.|  | | . ||.  ....|  
vkchkYWPekgtetygeltVtleeeeeladyei..rtfklkkkk........................ssesreVrqFhFtsWPdhgvpesatslLdlir

HSHSLNSRGN-PIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
....||.... ||.||||||||||||||..| ..                .|..|| | | | |.| .||.||  ||||..|. ||..| 
kvralnepdagPivVhCSaGVGRTGtfividaml................erikeektvD.iyqyvkalrkqRnamVqteeQYiFiheai
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 43-325 3.7e-41 136.2 In-house 39-279 (319) alignment 
Range on Protein: 43-325
Range on HMM: 39-279/319.0
SLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKVNVpgqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNR
..  . ...|  .||| ||..|.| || |..| |    ||||||..         |   .||||.|  .| . ||.| ...   .  ..||.| |||  .
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq.....erekfiatqaPlentiedfWrmvWee...essivvmltklveklk

EKCYQYWPRGgvddtvriasKWESPGgandmtqfpsDLKIEFVNVHKVKDyYTVTDIKLTPTDPLVGPvKTVHHFYFDLWKDMNKPEEVVPIMELCAHSH
 |. .|||.           ..|. |           | ..  . .. .| | . ..|| .    |   ..| ||..  | | . ||.   ...|  . .
vklkkywpee..........nfeeyG..........rlivtleeeeeled.yiirklklnkkssevet.RevkhfqyteWpdhdvPekatslldllkrir

SLNSR--GNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHAA
   ..    ||.||||||||||||||.||  .                .|  || . |.  ..| .|| ||  |||...|. |||.| 
ksrektqsgPivvhCsaGvGRtGtfivldaml................ervkeegvlDvf.stvsrlRtqRnimvqrpeqYkfiyeal
subfamily_egg_pd Subfamily egg 43-325 6.7e-16 52.8 In-house 31-266 (307) alignment 
Range on Protein: 43-325
Range on HMM: 31-266/307.0
SLGV--SIEPRNDARNRYVNIMpyERNRVHLKTLSG---NDYINASYVKvnvpGQSIEpGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEY
||    | . .. ||.. |.    .  ||.|.   |   .|.| | .||    |. .    .| .| | . | |.||.| . .   .   |||.|  .| 
slttaasdnnlekarskrvhck..dssrvklelrrGqylddfihanrvk....Gkpll.nefilaqaplkntvddfwrmvfqe...evqyivmltsrkes

nrEKCYQYWPRGGVDDTVRIaskwespggandmtqfPSDLKIEFVNVHKVKD-YYTVTDIKLtptdplVGPVktVHHFYFDLW-KDMNKPEEVVPIMELC
  |.|  |||.   |  | .                |  |.|| ..|..  |  ..|| .||      ||.       . . |  |.|.  .|   ... 
..erceyywpkaesdslvtv................pGslrienlkvdskadplfrvtklkl......vGgd..deerflehwqgdvnnssdvysplrvl

AHshsLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLdfknitersrhsdRAteEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
 .   |    .|..|..  || ...|..|..  . . |             |     |. |. . |  || .|   |..  ..||.|   
rk...lrnlskpvvvqdilGvskaatlvaieiallsll.............rG..pitkslvlravvflrlrrrlsvesvllylfvyrlv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 44-330 3e-46 153.0 In-house 48-292 (298) alignment 
Range on Protein: 44-330
Range on HMM: 48-292/298.0
LGVSIEPRNDARNRYVNIMPYERNRVHLKTL---SGNDYINASYVKvNVPGQSiepgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNRE
  |. .|.|  .||| .|....  || |..       ||||||... .  |..     .||||.|  .|  .||.|  ..   |  .|||.|.|.| .. 
kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh.aykgrn....afiatqaPltetvedFWrmvtee...digtiVmltnleeldkt

KCYQYWPRGGVD--DTVRIaskwespggandmtqfpsdlkiefvNVHKVKDYYTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHS
|. .|||  | .  .....                         .... ...  ..  ||. ..  .   ..|... |  | |   ||.   ...| .. 
kyhkywPdegketygeitv.........................sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkv

HSLNSRGN--PIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA-KYLNS
.  ...    |.||.|||||||.|||||.| ..                .|. .| . | . |.|  || .|...|||..|. |||.|  ..|.|
rasqqqagnkpvivqCsaGvgRsGtfiaidsvl................ervkkeqvvD.vfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 44-325 1.5e-38 127.7 In-house 38-279 (305) alignment 
Range on Protein: 44-325
Range on HMM: 38-279/305.0
LGVSIEPRNDARNRYVNIMPYERNRVHLKTLSGND---YINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNRE
. |  .  | |.||...|.... .|..|.. . .|   |||||||.    | . .   ||..||| ..| ..||.. ..  .    .|||.| ||| ...
idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd....gyk.rkkkyivaqgPlkntvadfWrliveekv...stivmltklveggkd

KCYQYWPrggvddtvriaskwESpggANDMTQFpSDLKIEFVNVHKVKDYyTVTDIKLTPTDPlVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSH-
||.||||              ||    .. ..|  ....|  . ....|| .  ..|..  |      .|| .. .  | |   |..   ...|  . . 
kCrqYWp..............es...ktekkef.gefsvelksektasdy.ieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsllslikrvqk

-SLNSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHAA
   ...| |..|||||||||||.|||.|  .                .|. .| . |.  ... ||||.|||||||.||. |.. | 
dqkkdkgvpllVhCsagvgRtGvfiavdial................erlkkEevvdvf.evlkqlRskrmkmvqtldqYvflhdal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 44-324 4.2e-34 113.1 In-house 40-283 (325) alignment 
Range on Protein: 44-324
Range on HMM: 40-283/325.0
LGVSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKvnvpgQSIEPGYYIATQGPTRKTWDQFWQMC-YHNCPldnivIVMVTPLVEYNR
  |.  | | |.||. |.......|| |.|.      |||||||..     . ..   ..|.| |  .| . .|..    .|.     .|.|.  .. . 
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylr.....ddkkkdvflaaqaPltatindlWrlvldWrcs.....vvvvlneldlgk

EKCYQYWPRggvddtvRIaskwespGganDMTQFpSDLKIEFVNVHKVKDYY-TVTDIKltptDPLVGPVKTVHHFYFDLWKDM---NKPEEVVPIMELC
..| .|||.       ..       |   .  .|   |..... . .. ||   | |.|    ..  |  ..|. | .  |.||   ..|  ...|..| 
drcavywpk.......em.......g...ksktf.Gglevklrtieeisdyvhrvldvk....qvkkGetrsvkqfqlqswddmGvqkrpatlisilqlv

AHSHSL---NSRG-NPIIVHCSAGVGRTGTFIALDHLMHdtldfKNITErSRHsDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
 . .     |...  ||.|||||||||||.||.|  ..      | |.| ||  |          | . | .|| .| .||.| ||. .||.|
kavservtantkastpilvhcsaGvGrtGvfislysala.....kviee.srv.d..........ifgfvkklrkdrpsmvetvdqyiliyea
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 44-149 1.5e-22 75.0 In-house 39-135 (287) alignment 
Range on Protein: 44-149
Range on HMM: 39-135/287.0
LGVSIEPRNDARNRYVNIMPYERNRVHLKTlSGNDYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNREKCY
. ..| ..|  .||. .|.... .|| ||    .|||||....    | . |   .|....|  .|  .||..  .. .    .|||.. . | ..|.||
vthniasqnkdknRltqilvpdnyrvllkg.ehpdyinavfid....gyk.ekkafiiaesPmfntarnfWkliddrnv...taivmlcqekendeevcy

QYWPRG
|||| .
qyWpee
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 44-148 4.1e-18 60.4 In-house 41-140 (315) alignment 
Range on Protein: 44-148
Range on HMM: 41-140/315.0
LGVSIEPRNDARNRYVNIMPYERNRVHL---KTLSGNDYINASYVkvnvPGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNRE
| |. .  |  .|||.||..|.. ||.|   .. .. ||.||...    .| .  .  |||.|||   . . ||.. ...   |   |||.| ||| ...
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfi....dGyn.kkrryiaaqgpnvasvkdfwrlvfee...digkivmltnlvegekr

KCYQYWPR
|. .||| 
kaekywpd
0050432 (Phosphotyrosine protein) phosphatases II 45-328 1.1e-68 227.2 In-house 61-298 (308) alignment 
Range on Protein: 45-328
Range on HMM: 61-298/308.0
GVSIEPRNDARNRYVNIMPYERNRVHLkTlSGNDYINASYVKVNVpgqSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
 |.  |.|  .|||..|.||...||.|   .|.||||||||.. .   |. |  .||||||. .|.. ||.|....   .  ||||.| |||..||||.|
svallpenkdkNrykdilpydhsRVkl.d.egsdYInAsyvdgys...sklprkfIatqgPlpntvedFwrmvweq...nvrvIvmLtklvengrekcaq

YWPRGGVDDTVRIaskwespggandmtqfpSDLKIEFVNVHKvKDYYTVTDIKLTPTDPLvgPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNsR
|||    ......                  ........... .|.|||. ..||...    ...||.||..  |.|.. |... ...... . .. . .
Ywplelgggsley.................gkftvtllseev.lddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelvrksl.p

GNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
|.||.|||||||||||||||||.|..     ....                 ....| .||.||. ||||..|.||.|.|. ..
ggpivVHCsaGvGRtGtfialdllleqlekeggvd.................vfeavkklReqRpgmvqtpeqylflyralley
0047943 (Phosphotyrosine protein) phosphatases II 45-327 1.4e-61 203.8 In-house 31-270 (273) alignment 
Range on Protein: 45-327
Range on HMM: 31-270/273.0
GVSIEPRNDARNRYVNIMPYERNRVHLkTLSGNDYINASYVkvNVPGQSIEpgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
 |.. |.|  .||| .|.||...||.| . .|.||||||||  ... .. .   .||||||. .|.. ||.|....   .  ||||.|.||| .||||.|
svallpenkdknrykdilpydhsrvkl.gdggsdyinAsyv..dgynlkrk...fiatqgPlpntvedfwrmvweq...nvrviVmLtelvelgrekcaq

YWPRGgvddtvriaskwespggANDMTQFPSDLKIEFVNVHKvKDYYTVTDIKLTPTDplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS-
|||                    .....   ........... ||.|||. ..||...   | ..||.||..  | |.. |. . ...|.. . .. .. 
Ywple.................ggelsltygkftvtllseet.kddytvrtleltnlg..tgesrtvthfhytgwpdhgvppslesllefielvrkalea

--RGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
  ...|..|||||||||||||||||.|..     ....                 ....| .|||||. |||| .|..|.|.|. .
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.................vleavkllrsqRpgmvqtpeqyrflyealle
subfamily_PTPN23_pd Subfamily PTPN23 45-324 7.3e-42 138.2 In-house 36-275 (288) alignment 
Range on Protein: 45-324
Range on HMM: 36-275/288.0
GVSIEPRNDARNRYVNIMPYERNRVHLKtLSGNDYINASYVKVNVPGQsiePgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
 ..|  ..  .||. .|.||..|||.|.  | .||||||.||  .||    |  .||||.| ..|   ||.| |..      ||||..   | ...|. .
siaiaklyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgc...P.dfiatqaPlqstlnDFWlmvyeq...kssviVmllskeelgkpkvdr

YWPRGgVDDTVRIASkwespggandmtqfpsdLKIEFVNVHKVkDYYTVTDIKLTPTDPlvGPVKTVHHFYFDLWKDMNK---PEEVVPIMELCAHSHSL
|||    ..||.                    |..   .|..  ...   ..||.  |.    ||.| |  .  | ..     ||... ...   .... 
YwPed.kgetvkfgd.................lsvtlksvret.ethvervlkletlda..davksvshlqltsWpelGvPasPetllqfldevesayea

NSR--GNPIIVHCSAGVGRTGTFIALDHLMHDTlDFKNITErsrhsdrateeytrdLIEQIVLQLRSQRMKMVQTKDQFLFIYHA
. |    |..|||||||||||.|  .   .... . .|.                  | |.| .|| ||  |||.|.|. | |.|
vqrksktPlvvhCsaGvgRtgvfalvyaavrel.ekgngll...............diiqvvsrlreqRrfmvqekeqlkfsyea
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 45-323 5e-25 83.0 In-house 26-253 (267) alignment 
Range on Protein: 45-323
Range on HMM: 26-253/267.0
GVSIEPRNDARNRYVNIMPYERNRVHLKTlSGNDYINASYVKVNVPGQsiepgYYIATQGPTRKTWDQFWQMCY-HNCPldniVIVMVTPLVEynrEKCY
  ||   |..|||. . .||. .|| |.| . ..|||||||.    ..      .|.||.| ..|  .|...   ...|    |||..|.  .   ..  
sqsiaeknqernrlddnlpyddtrvilrt.keeeyinasyvegyktkn.....afivtqdplkntitdfltvihdqkvp....vivlltkvft...dnir

QYWPRggvddTVRIASKWEspggandmtqfpsDLKIEFVNVHKVKDYYTVTdIKLTPTDPlvgPVKTVHHFYFDLWK-DMNKPEEVVPIMELCAHShSLN
..||       .  | |..             || .|.   .. .||  .| ..|   .      . |  .|.  |. . |.   . |.. . |.   |.
lfwPP.....kmgqakkyq.............dltvehslekeendyqiit.lelkfkne...sahnvtlyyykkwnintnnkpylkplfgilakn.qle

SRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYH
  ..|..|.||.||||.|||. .|  .                .|| .| . | | . ....||||. .|.||.....|..
ngnrPlvvacsdGvGrsGtflvidsql................eraktegvsd.ifdflrkirsqriglvdtkeryiyihe
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 45-152 3.1e-17 57.2 In-house 33-137 (301) alignment 
Range on Protein: 45-152
Range on HMM: 33-137/301.0
GVSIEPRNDARNRYVNIMPYERNRVHLKTLSG-----NDYINASYVKvnvpgQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNR
 |... .| | ||. || .|. ||. ||. .      ..||||||..        |   .||.||| .||  .||.. ... |   . ||||| | |  .
tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid.....gysekkkfiaaqgpmkktlvdfWrliwqekp...vsivmvtnlkegtk

EKCYQYWPRGGVD
.||.||||..  .
skceqywpnseae
0039614 (Phosphotyrosine protein) phosphatases II 46-329 1.8e-62 206.9 In-house 50-289 (297) alignment 
Range on Protein: 46-329
Range on HMM: 50-289/297.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLSG----NDYINASYVkvnvPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNReK
..  | |  .|||..|.||...||.||.. |    .||||||||    .| .. .  .||||||. .|.. ||.|....   .  ||||.|.|||..| |
iallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPlpetvedFwrmvweq...gvtvivmLtklvelgr.k

CYQYWPRGgvddtvriaskwespggaNDmtqFPSDLKIEFVNVHKvKDYYTVTDIKLTPTDPLvgpvKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSL
|.||||                     .      |.......|.. .|.|||. ...|....     .||.|| .  | |.. |. .  ..|..   .. 
caqywpee..................gg...tygdftvtllkveh.ldgytvrtlevtnnges....rtvthfqytgwpdhgvppslellleflelvrea

NS---RGNPIIVHCSAGVGRTGTFIALDHL-----MHDTLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYLN
..   .|.|..|||||||||||||||.. .      . ..|                      ....| .||.||...||| .|. |.|.|...| 
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd......................vleavkelreqRpgavqtpsqyrflydallell
0036941 (Phosphotyrosine protein) phosphatases II 46-328 2.1e-61 203.2 In-house 33-276 (297) alignment 
Range on Protein: 46-328
Range on HMM: 33-276/297.0
VSIEPRNDARNRYVNIMPYERNRVHLkTLSGNDYINASYVkvNVPGQSIEpgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQY
|.. |.|  .||| .|.||...||.| . .|.||||||||  ...... .   .||||||. .|.. ||.|....   .  ||||.|.|||..||||.||
vallpenleknRykdilpydhtRVkl.ddegsdYinAsyv..dgydlkrk...fIatqgPlpntvedFWrmvweq...nvtvIvmltelvelgrekcaqy

WPRGgVDDTVRIASkwespggandmtqfpsdLKIEFVNVHKV-KDYYTVTDIKLTPTdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS-
||   .....                     .......|..| .|.||.. ...|.|    |...||.||..  | |.. || . ......   .. .. 
wple.egesltygd.................ftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--RGNPIIVHCSAGVGRTGTFIALDHL--------MHDTLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
  .|.|..|||||||||.|||||.| .        .. ..|                      | ..|..||.||. .||| .|..|.|.|  .|
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd......................ileavkklReqRpgavqtleqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 46-327 3.2e-60 199.3 In-house 39-275 (278) alignment 
Range on Protein: 46-327
Range on HMM: 39-275/278.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVkvnvPGQSIEPGyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKC
... | |  .|||..|.||...||.|. |.|   .||||||||    .| .. .. .||||||. .|.. ||.|....   .  .|||.|.|||..|.||
iallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprk.fiatqgPlpetvedFwrmvwel...gvttivmLtelvelgrvkc

YQYWPrggvDDTVRIASkwespggandmtqfpsdLKIEFVNVHKvKDYYTVTDIKLTPtdPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLN
.||||    ......                   .......... .|.|||.....|.     |...||.|...  | |.. || . ......   .. .
aqYwp....ggsltygd.................ftvtllkeeh.lddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

S-RGNPIIVHCSAGVGRTGTFIALDHLM-----HDTLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
. ...|..||||||||||||||||. |.     . ..|                      .|..| .||.||...||| .|. |.|.|...
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvd......................leeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPN6_pd Subfamily PTPN6 46-327 5.6e-49 161.8 In-house 48-295 (306) alignment 
Range on Protein: 46-327
Range on HMM: 48-295/306.0
VSIEPRNDARNRYVNIMPYERNRVHL--KTLSGNDYINASYVKVNVPGQSiepGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCY
 .  |.|  .||| ||.|.. .|| |  . ..|.|||||.|.| .|.|..    .||||||  ..|  .||.| . .   .  ||||.|  || ..|||.
egakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd...ksyiatqgclettvsdFWrmvwqe...nsrvivmttkevErgkekCa

QYWPRGGVDDT---VRIASKWESpggandmtqfpsdlkiefvnvhkVKDYYTVTDIKLTPTDPlVGPVKTVHHFYFDLWKDMNKPEEVVPIMELC----A
.|||    ...   ... .  |.                        ...|.. ..... ..   .  ..|... |  | | . |..   ....     .
rYWPdeeekeeyGkisvtnvsek.......................sladYilRelsvskkkk.kkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

HSHSLN-SRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfKNITERSRhsdrateEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
....|. ..  ||.||||||.||||||| .| |.      |.|...         ..  | |...| ..|.||  .|||..|. |.|.| |.
kqeeleeaeagpivvhCsaGiGRtGtfiviDill......kliekkgl.......dadid.iqklvksvreqrsglvqteqqykfvykaikk
subfamily_PTPN3_pd Subfamily PTPN3 46-324 1.1e-43 144.2 In-house 35-270 (280) alignment 
Range on Protein: 46-324
Range on HMM: 35-270/280.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLSGnDYINASYVKVNVPGQSIEPgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQY
..  |.| ..||| .|.||.  ||.||  .  |||||.||....|....    ||||||| .||  .|||| ...   .  .|||.| |||  | ||.||
aarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvn.ryiatqGPlaktatdfWqmvweq...ksslivmlttlverGrvkChqy

WPRggVDdtvriaskwespgganDMTQFPsDLKIEFVNVhKVKDYYTVTDIKLTPTDplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLN-SR
||.   .                | ...  .....  .  . .  | . .. |. ..      ...... .  | | . |..   ..|.  . ..|  ..
WPe..te................deleyg.efsvkceke.detksyvlrelvlkdke..tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk

GNPIIVHCSAGVGRTGTFIALDHLMHdtldfknITERsrhsdrATEEYTRDlieqIVLQLRSQRMKMVQTKDQFLFIYHA
 .|..||||||.|||| .|.|.  ..       ..|.      | . |  |    || ..| ||. .|||..|. |. .|
eePvvvhCsaGigrtGvlilletala.......liea......aepvypld....ivrtmrdqramlvqtasqykfvCea
subfamily_Ptp69D_pd Subfamily Ptp69D 46-324 5.3e-42 139.0 In-house 42-281 (307) alignment 
Range on Protein: 46-324
Range on HMM: 42-281/307.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKVNVpgqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKC
|| .  |  .||| .|......|| ||.. |.   ||||||..|        |   .|| |.|   | . ||.|       .  .|||.. | |.||.||
vsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyk.....ekkkfiaaqdPveatigDfWRmiaeq...evtlivmlsnlteknrkkc

YQYWPRGgvddtvriaskwespgganDMTQFPsDLKIEFVNVHKVKDyYTVTDIKLTPTD---PLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSH
 .|||                     | .|.  |. ...|. .| .| |.  ..... ..   . |   . |  . .  |||.. ||    ...|  . .
akYWpie...................devqyg.dilvklvseekhsd.yiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvr

SLNSR-GNPIIVHCSAGVGRTGTFIALDHLMHdtldfkniteRSRHSDRATeeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.|..    ||.|||||||||.|.|.||| |..          . .  |..        | ..| .|||||  .||  .|. |.|.|
elyklnrsPivvhCsaGvgrsgifvaldsllq..........qlkaedkvd.......ifetvkdLrsqRnllvqsleqYvflyra
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 46-325 5.4e-34 112.2 In-house 37-272 (515) alignment 
Range on Protein: 46-325
Range on HMM: 37-272/515.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLS---GNDYINASYVKvnvpgqSIEP-GYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNREK
|. |  |  .||| ||.||...|| |. .     .||.||||..      |..    |||.||| . . | ||.. ... .     |.||| | | .. |
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip......sfdndkayiasqgPnkasvddfWrlvlqenv...ttiamvtklkegdkik

CYQYWPrggvddtvriaskwESPGganDMTQFPsDLKIEFVNVHKVKDYyTVTDIKLTPTDPlvgpVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSL
| .|||              . ||   |  .|   .|.| | ..   .  .   ....  |     ..||  | |  | |   |..   .. |     . 
cgkyWP..............dkpg...dsvkfG.sikvelvsleactgg.ikrkltvlkgdd....srtvtqfhfteWPdkGvpkhtssllklikevkad

-NSRGNPIIVHCSAGVGRTGTFIALDHLMHDTldfknitERSRHSDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
 .    |.|.|||||||||| .|..|  . .        . .|  |          . ..| ..| .|...|||..|. ||| | 
hgqythpliihcsaGvGrtGvvisidsvvaha.......kttrmvd..........vfnfvtnirqkrpylvqtqeqyafiygav
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 46-325 9.5e-34 111.6 In-house 38-273 (315) alignment 
Range on Protein: 46-325
Range on HMM: 38-273/315.0
VSIEPRNDARNRYVNIMPYERNRVHL---KTLSGNDYINASYVKvnvpgqSIEP-GYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNREK
|. |. |  .||| ||.|....|| |        .|||||||.|      |..    |||.||| . . | ||.| ... .     ||||| . | .. |
varetinfkknryknilPldsarvkleviddsPdsdyinasyik......svdddkayiasqgPlkasvddfwrmvlqekv...ttivmvtkkqegdkik

CYQYWPRggvddtvRiasKwespggaNDMTQFPSdLKIEFVNVHKVKDYYTvtdIKLTPTDplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSL
| ||||        |   |        | ..| | .|.| ....   |  .    ||.  .      .||  | |  | |   ....  ...|     . 
crqywPd.......r...k.......adsvefGs.ikvellsleadtdgva...rklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkad

-NSRGNPIIVHCSAGVGRTGTFIALDHLMHDtldfknItERSRHSDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
 ...  ...||||||||||| .|..|. . .      | .|.|  |          . ..| .||..|...|||.... ||| | 
ngkkefsllvhcsaGvGrtGvvisidevvaq......i.krtrsvd..........vfnfvknlrakrpylvqteeeyafiydav
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 46-151 1.4e-25 85.0 In-house 40-140 (318) alignment 
Range on Protein: 46-151
Range on HMM: 40-140/318.0
VSIEPRNDARNRYVNIMPYERNRVHLKTLS---GNDYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKC
 |.|| | |.|||.||..|.. ||.|..|.   | |||||.|.     |   .   |||.|.|  .| . ||.| .     .  ||||.| ..|  ..|.
kslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyid....Gyr.rkkayiaaqaPlpetieDfWrmvWeq...nsavivmltqeeergkakv

YQYWPRGGV
 .|||  | 
hryWPskgs
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 46-149 2.8e-24 80.5 In-house 25-125 (297) alignment 
Range on Protein: 46-149
Range on HMM: 25-125/297.0
VSIEPRNDA--RNRYVNIMPYERNRVHLK-TLSGNDYINASYVKVnvPGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKC
 |   || .  .||| .|. .. .||.|. . ...||||| ||    | .  .. .|| .|||...| |.||.. ...   |  |||||. | |  |.||
fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf..pdee.adlkyilaqGplsatvddfwtlvaeq...dvrvivmvaklqedGrdkc

YQYWPRG
. |||. 
apywpsv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 47-326 4.3e-44 145.7 In-house 36-273 (281) alignment 
Range on Protein: 47-326
Range on HMM: 36-273/281.0
SIEPRNDARNRYVNIMPYERNRVHL---KTLSGNDYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCY
| .. |  .|||.||. |.  ||..   .. . .|||||..|.    | . ..  |||||||  .. ..|||| . .   .  .|||||  .| .. ||.
skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvp....gyk.gekeyiatqgPvPaslvafWqmvweq...kvsaivmvtreieagklkCh

QYWPRGGVddtvriaskwespggandmTQFPSDLKIEFVNVHKVKDyYTVTDIKLTPTDplvGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS
.||| .                     .   .|....... .. .  |    .||. ..   |. ..|... .  | |   |..   ..|  .  ..|..
rYWPddns...................elkygdvtvkstaeeekat.yierkfkleres...getreveqlaytaWPdhGvPattkellefrkevlklte

RGN--PIIVHCSAGVGRTGTFIALDHLMHDTldfkniTERSRHSDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
. .  |...|||||||||||.|||| |..        ... .. |          ....| .|| .|. ||||  |. |.|.| .
kktkaplvihCsaGvGrtGtyialDrlvkav......eaeleeld..........vkavvaelrkernlmvqtvvqyefvykavl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 47-329 1.1e-37 124.6 In-house 4-243 (250) alignment 
Range on Protein: 47-329
Range on HMM: 4-243/250.0
SIEPRNDARNRYVNIMPYERNRVHLKTLS---GNDYINASYVKVNVpgqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREkCY
. .|.|  .||| .|....  || |.. .     ||||||....       |   .||||||  .|  .||.| ...   .  .|||.| |.| ... . 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd.....erkafiatqgPlqatiedfWrmvlee...ksgtivmLtnLkesekt.yh

QYWPrggVDDTvriaSKWespGgandmtqfpsDLKIEFVNVHKVKDyYTVTDIKLTPTDPlvGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS
||||   |. .     |.   |          |....  . ..  | ||.. .||. .       ..| .. |  | |   ||.   ..||  . .. . 
qywP...veka....eky...G..........dvtvsllskeefad.ytkrklklskakk..aderivrqlhfvvWPdkgvPevatavLellkkvqasqq

R--GNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA-KYLN
.   .|.||.|||||||.|.|||.| ..                .|. .| . | . ... .|| .|...|....|. |.|... |.|.
qagnaPvivqCsaGvgrsGafiaidavl................erlkkekvvd.vfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN14_pd Subfamily PTPN14 47-327 7.2e-37 122.0 In-house 44-295 (300) alignment 
Range on Protein: 47-327
Range on HMM: 44-295/300.0
SIEPRNDARNRYVNIMPYERNRVHLKTLSG--NDYINASYVKVNVPGQSIEpgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
.  | |  .||. ...||| |||.|..     ..||||| .|| | |.. .   ||..||| ..|  .|||| . .   .  .|||.|   |  .||...
aklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkers...yivaqgPleltvqdfWqmvWeq...gvqlivmlteeeedgkeksfk

YWPRGGVDDTvRIaskwespgganDMTQFpsDLKIEFVNvhKVKdYYTVtdIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIME-------LCAH
|.|. .     ..           .  .|   .  .|..  . .  ..   ..|.    . .  .||.|. .  | | . ||.| . ..       .. .
yfPkleskkk.tv...........efgkf..kvttkfse..dsd.svit..tglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

SHSLN---SRGNPIIVHCSAGVGRTGTFIALDhLMHDTLDFKNITErsrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA-KY
..| .   ..  |..|||||||||||  |  | |.  ||.  .  .                |.... .|| ||| .|||  |. |.|..  ||
tnseveskeskPPvlvhCsaGvGrtGvlilsd.lliatlehneeid................ikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 47-130 1.1e-08 29.0 In-house 91-168 (244) alignment 
Range on Protein: 47-130
Range on HMM: 91-168/244.0
SIEPRNDARNRYVNIMPYERNRVHLK-TLSGNDYINASYVKvnVPGQSIEpgyYIATQGPTRKTWDQFWQMCYHNCplDNIVIVM
...| |  .||    .|.. ||| |     || |||||.|     |.. |   || || |   |  .||.|        |...|.
afnpnnswknregaglpfdfnrvplskgsmgntyinasfvg..clgrtae...yiltqhpladtsmdfwkmmlerh..vnvlvvl
0042113 (Phosphotyrosine protein) phosphatases II 48-328 3e-58 192.5 In-house 5-242 (245) alignment 
Range on Protein: 48-328
Range on HMM: 5-242/245.0
IEPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVkvnvPGQSIEPGyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
. | |  .|||..|.||...||.|.  .|   .||||||||    .|  | |. .||||||...|.. ||.|....   .  .|||.|...|..|.||.|
llpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpk.fiatqgPlpetvedfwrmlwel...gittivmLteeeelgrvkcaq

YWPRggvDDTVRIaskwespggandmtqfpSDLKIEFVNVHKvKDYYTVTDIKLTPTdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS-
|||    ......                  |.......... .|.|||. ...|..    .....|.|...  | |.. |. .  . ...   ..  . 
ywpl...geslty.................gdftvtllseeh.lddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalae

-RGNPIIVHCSAGVGRTGTFIALDHLM-----HDTLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
 ...|..|||||||||||||||.. ..     . ...                      .|..| .|||||...||| .|. |.|.|...|
dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs......................leeavkelrsqRpgavqtpsqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 48-327 4.4e-58 192.0 In-house 6-240 (243) alignment 
Range on Protein: 48-327
Range on HMM: 6-240/243.0
IEPRNDARNRYVNIMPYERNRVHLktlSGNDYINASYVKVNvPgqsiepgYYIATQGPTRKTWDQ----FWQMCYHNcplDNIVIVMVTPLVEYNREKCY
. | |  .||| .|.||...||.|   .|.|||||....|  |       ..||||||. .|...    ||.|....   .  ||||.|.|||..||||.
llpenlsknrysdilpydhsrvkl...egsdyinanliyvt.p.......rliatqgPlpetveddlasfwrmlwel...gitvivmltelvElgrekca

QYWPrggvddtvriaS-----KwespggandmtqfpsdLKIEFVNVHKvKDYYTVTDIKLTPtDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHS
||||           .     .                .........  .|.|||. ..|..  .| .....|.|...  | |.. |... ...... . 
qywp...........gevtygd................ftvtllseeh.lddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldev

HS---------LNSRGNPIIVHCSAGVGRTGTFIALDHLMHD-TLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMK-MVQTKDQFLFIYHAAKY
..          ...|.|..||||||||||||.||.. ...  ..|                      .|..| .||.||.  .||| .|. |.|.|...
refieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvd......................leeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN9_pd Subfamily PTPN9 48-324 1.7e-33 111.0 In-house 38-285 (297) alignment 
Range on Protein: 48-324
Range on HMM: 38-285/297.0
IEPRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
  . |  .||| ... |.. ||.|......   |||||..|     |   ..  .|||||| .|| . ||.| . .   . .||||.| .||  | || |
klranleknrytdvlcydetrvvlakvdedeasdyinanfvd....Gyk.qkkafiatqGplkktvsdfWrmvWeq...evlvivmttrvvergrlkcgq

YWPRGgvddtvriaskwespggANDMTQFpSDLKIEFVNVHKVKDYyTVTDIKLTPTDplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCA--------
||| .                  .....| .||... |.|.. .|| .|. .... ..   .  ..| || |  | |   |..   ....          
yWple.................eessaef.gdlsvsnveveeeedy.kvrvleiknvk..teesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

------HSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfkniterSRHSDRATEEytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
      ...  . .| ||.||||||.|||||||.||  .            ||  . .| .     . . | .||.||  ..|| .|. | | |
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldicl............srleevgtvd.....vvetvkllrtqrafsiqtpeqyefcyla
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 48-324 2.8e-29 96.7 In-house 41-231 (392) alignment 
Range on Protein: 48-324
Range on HMM: 41-231/392.0
IEPRNDARNRYVNIMPYERNRVHL---KTLSGNDYINASYVKvnvpGQSIEpGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNrekcyq
 .. |  .||| ||.||...||.|      . .||.||||..    .   |   |||.|||   . |.||.| ...   .   |.||| | | .      
qkeinlkknryknilpydsarvkleviddipdsdylnasyip....sfdne.kayiasqgpnaaslddfwrmvfqe...nvttiamvtklkegd......

ywprggvddtvriaskwespggandmtqfpsdlkiefvnvhkvkdyytvtdikltptdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSH-SLNS
                                                               ..||  |.|  | | . |. .  ....    .    .
...........................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq

RGNPIIVHCSAGVGRTGTFIALDHLMHDTldfknitERSRHSDrateeytrdLIeQIVLQLRSQRMKMVQTKDQFLFIYHA
   |.|.||||||||||  |..| ..  .       ...|  |         .. ..| ..| .|  |||||.|. ||| |
ythpliihcsagvgrtgvvisidsvvaha.......kktrmvd.........vf.nfvtnirrkrpymvqtkeqyafiyga
subfamily_PTPRN_pd Subfamily PTPRN 48-151 3.5e-19 63.6 In-house 52-151 (297) alignment 
Range on Protein: 48-151
Range on HMM: 52-151/297.0
IEPRNDARNRYVNIMPYERNRVHLKTL---SGNDYINASYVKVNVPGQSIepgyYIATQGPTRKTWDQFWQMCYHNCpldNIVIVMVTPLVEYNREKCYQ
 ...|  .||. ...||. .||.||.    . .|||||| .  . | ...    |||||||  .|  .|||| ...     .|||..|.| | . ..|..
kaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapa....yiatqgplastvadfwqmvweqG...vvvivnltrleeegvkqckr

YWPRGGV
|||  | 
ywpdeGs
0045098 (Phosphotyrosine protein) phosphatases II 49-328 4.1e-60 198.9 In-house 30-271 (278) alignment 
Range on Protein: 49-328
Range on HMM: 30-271/278.0
EPRNDARNRYVNIMPYERNRVHlktlsgnDYINASYVKVNvpgqsiePGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
 . | ..|||..|.||...||.       |||||||...        |  .||||||. .|...||.|....   .  ||||.|.|||..||||.|||| 
ylgnldknRykdilpydhsrVk.......dYINAsyidgy.......pkkfIatqgPlpstvadfwrmlwel...gitvivmltelvelgrekcaqywpe

ggvDDTVRIaskwespggandmtqfpSDLKIEFVNVHKVkDYYTVTDIKLTPT--DPLVGPVKTVHHFYFDLWKDMNKPEEV--VPIMELCAHSHSLNS-
   ......                  |......... . |.||......| .   .  ..  .|.|...  | |.. |..    .. ||.   .. .. 
...ggslty.................gdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

-------------RGNPIIVHCSAGVGRTGTFIALDHLMHD---TLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMK-MVQTKDQFLFIYHAAK
             .|.|..||||||||||||..|.. ...    ..|                      ....| .|||||.  .||...|. |.|... 
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd......................lleavkelrsqRpglavqnleqyrflyefll

YL
.|
el
0040439 (Phosphotyrosine protein) phosphatases II 49-327 4.8e-57 188.7 In-house 8-244 (249) alignment 
Range on Protein: 49-327
Range on HMM: 8-244/249.0
EPRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQY
 | |  .|||..|.||...||.|. |.|   .|||||||...   ..      .||||||. .|.. ||.|....   .  ||||.|.|||..||||.||
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.....fiatqgPlpetvedfwrmlwel...gitvivmLtslvelgrekcaqy

WPRggvDDTVRIaskwespggandmtqfpSDLKIEFVNVHKvKDYYTVTDIKLTPTdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS--
||    .... .                  |.......|.. ||.|||. ..||..    |.. ||.|...  | |.. |. . ......   .. ..  
wpl...ggsley.................gdftvtllsvev.kddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel

-RGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
 .|.|..|||||||||||||||.. ...     ....                 .|..| .|||||...||. .|. |.| |...
pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd.................leeavkllrsqRpgavqnpeqyrflyealle
subfamily_PTPRA_pd Subfamily PTPRA 49-325 4.6e-45 148.9 In-house 55-291 (330) alignment 
Range on Protein: 49-325
Range on HMM: 55-291/330.0
EPRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKvnvpGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQY
.  |  .||.|||.||. .||.| ...|.   ||||||...    |   |  ..||.||| ..| . ||.| .     .   |||.| | | ..|||.||
keenkeknrvvnilPydfsrvilsvkeGveesdyinasfid....Gyk.ekdkfiaaqGPkeetvedfwrmiweq...ksativmltelkerkeekcaqy

WPRGGVddtvriaskWESpGgandmtqfpsDLKIEFVNVHKVKDyYTVTDIKLT--PTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS
||  |.         .   |          ....|  ..  ..| ||| .. ..  |      ... |. |.|  | |.  | | . ...| .. ..|| 
wPdeGl.........vty.G..........nirvevedetvlvd.ytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

-RGNPIIVHCSAGVGRTGTFIALDHLMHDTldfknitersrHSDRATEEYtrdlieQIVLQLRSQRMKMVQTKDQFLFIYHAA
  ..||.||||||||||||||.|| ...             ...|  . .      ..| .|| || .||||. |. |||.. 
qsagpivvhcsaGvGrtGtfivldavlerv...........kaerkvdvf......efvkrlrlqrpqmvqtdeqyefiykvl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 49-325 1.6e-34 114.4 In-house 47-280 (297) alignment 
Range on Protein: 49-325
Range on HMM: 47-280/297.0
EPR-NDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKVNVPgqsiepgYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNReKCYQ
| . |  ..|| ||.||...||.|. .  .   ||.|||.||.|          .|.|| | . | . ||.| ... .    .|||.. . | .. || .
ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.......rlittqmPmkatvadfWamvldeqv...stivmlnddnerdk.kcar

YWPRGGVDDtvriaskwespggandmtqFpSDLKIEFVNVHKVKDYYTvTDIKLTPTDPLVGpvKTVHHFYFDLWKDMNKPE-----EVVPIMELCAHSH
||.  ||                     |  |. ..   |.. . .    ....|  .. .   . |. . |  | | . ..      .. ...   ...
yWsdkgvtt...................f.GdvsvvllsvsereGfik.relevtkgkakar..rvvkqyqfveWPdkaverkdsassllklisevrkdf

SLNSRGnPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNItersrhsDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
| |. | |..|||.||||||| ....|  . .  . |..       |          | ..| .|| .|...||||.|. |.| | 
sqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekev.......d..........ifglvkklrqerpylvqtkeqykfvyvav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 49-149 4e-16 53.5 In-house 34-130 (281) alignment 
Range on Protein: 49-149
Range on HMM: 34-130/281.0
EPRNDARNRYVNIMPYERNRVHLKT----LSGNDYINASYVKVNVpgqsIEPGyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQ
.| |. .|||.||   .  ||.||         ||| | |..  .    .. | || |||| ..|  .||.| ...   .   |||.  ..| ||||| .
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf....lkrg.yiltqgpkketradfwrmiwqe...nttaivmlcqfletnrekcae

YWPRG
|.|| 
yfprn
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 49-86 8.2e-06 19.4 In-house 44-84 (440) alignment 
Range on Protein: 49-86
Range on HMM: 44-84/440.0
EPRNDARNRYVNIMPYERNRVHLK---TLSGNDYINASYVK
 | |  .||| ||. |...|| |.    .  .|||||||..
lpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 50-324 3.8e-40 133.1 In-house 59-286 (319) alignment 
Range on Protein: 50-324
Range on HMM: 59-286/319.0
PRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKvnvpG-QsiEPGYYIATQGPTRKTWDQFWQMCYH-NCpldnIVIVMVTplveynREKCYQ
..|  .||..||.....|.| |. | |    ||||||.|.    | |   .  |||.|||   | . ||.| .  ||      ||..|      ..|| |
dqnkdknriinilafdknvvklerliGeefsdyinasfvt....Gyq..rkdkyiaaqGPldntladfWrmiweync....stivllt......kdkcsq

YWPRGGVDDTVRIASKWESPGGANDmtqfpsdlkiefvnvhkvkdyYTVTDIKLTPtDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAH---SHSL
|||  .|    |   | .|   ...                     |.| ||.|.  |     .. .. |.|  | |. .|.  ...| |  .    .| 
ywplkivikeerfkvkvdsveetae.....................yvvrdielse.dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

NSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.   ..|.|||||||||||..|.|| |.                ||  ||   | . ..| .|| || ..||   |. ||| |
enhranivvhcsaGvGrtGvyivldvll................drmkeekqvd.vynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 50-324 1.8e-39 131.0 In-house 23-250 (284) alignment 
Range on Protein: 50-324
Range on HMM: 23-250/284.0
PRNDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKvnvpG-QsiEPGYYIATQGPTRKTWDQFWQMCYH-NCpldnIVIVMVTplveynREKCYQ
..|  .||...|.....|.| |. | |    ||||||...    | |   .  |||||||   | . ||.| .  ||      ||..|      ..|| |
dqnkdknrighilafdknvvklerliGeefsdyinasfit....Gyq..rkdkyiatqGPldntladfWrmiweync....stivllt......kdkcsq

YWPRGGVDDTVRIASKWESPGGANDmtqfpsdlkiefvnvhkvkdyYTVTDIKLTPTDpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAH---SHSL
|||  .|    |   | .|   ...                     |.| ||.|.        ..... |.|  | |. .|.  ...| |  .    .| 
ywplkivikeerfkvkvdsveesee.....................yvvrdielsedg.kekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk

NSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.   ..|.|||||||||||..|.|| |.                ||  ||   | . ..| .|| || ..||   |. ||| |
enhranivvhcsagvgrtgvyivldvll................drmkeekqvd.vynfvrdlrqqrntlvqdlvqykfiysa
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 50-325 1.2e-36 121.0 In-house 31-262 (283) alignment 
Range on Protein: 50-325
Range on HMM: 31-262/283.0
PRNDARNRYVNIMPYERNRVHLKTLSGnDYINASYVKVNVPGQsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRG
 .|.  ||. .|.|....||.||..|  |||||... |.   .  .   ||..|.| ..|   ||.| ...   .   |||.|.| | .|.|| ||||. 
denkrknrnqeivpadqwrvelksesr.dyinavfipvsksyk..qdkkyiiaqsPldrtvvdfWkmvfde...kitaivmltklqedlrikCsqyWPkr

GVDDTVRIASKWESPGGANDMTQFPSDLKIEfvnvhkvkdyytvtdikltptdP-----LVgpvktVHHFYFDLWKDMNKPEEVVPIMEL-CAHSHSLNS
|  |    .   .   . | ...    |. .                            |.     . |. .. | ....   .  .. .    |   .|
GsedyGeftvtlrkettsnsfiikelllrvn......................ssakstll.....lahyqvidWleygeqaiinslvkfnkvislqtes

RGNPIIVHCSAGVGRTGTFIALDHLMHDTLdfknitersrhsdratEEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
.  ||.||||.|.|||..|||.   ..| |                 |   | . ..|  .| ||| .|||.||. ......
kkgPivvhCstgiGrtavfiaasasvkdal................tesvvd.vfavvkimreqrmmavqtldqyklvhelv
subfamily_ptpA1_pd Subfamily ptpA1 50-274 4.3e-27 89.9 In-house 45-257 (418) alignment 
Range on Protein: 50-274
Range on HMM: 45-257/418.0
PRNDARNRYVNIMPYERNRVHLKTL---SGNDYINASYVKVNVPGQsiepgyYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNREKCYQYW
 .| ..||| ||.| .. ||.|| .    |.||||| |.    | |      .|.||||  .|  .||.| . |      .|||..   |  | || .||
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq......fictqgplpntiadfwrmvwenrc...riivmlsresencrikcdryw

PRGGVDDTVRIAskwespGGANDMTqfpSDLKIEFVNVHKVKDYYTVT-DIKLTptdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCaHSH------
|     . . |       |  |..        .|.|.| .  .   .| .|.||    . |  . . .. .. | | | |.   |. .|  ||       
peqiggeqfsiy......gngnevf...gtysvelveviqdpereiitrnirlt....fegetrditqyqyegwpdhnipdhtqpfrqll.hsitnrqnq

--SLNSRGNPIIVHCSAGVGRTGTFIALDHLMhDTLD
    . |  |||||||||||||||| .   .|   ||
iipssdrnvpiivhcsagvgrtgtfctavimm.kkld
subfamily_CG42327_pd Subfamily CG42327 50-239 3e-12 40.8 In-house 26-191 (319) alignment 
Range on Protein: 50-239
Range on HMM: 26-191/319.0
PRNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKvnvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYW
.  . ..|..|..|    || |.  . .    |..||||.    |.   | .|||.| .  ..  .||.. . .      ||| .| | |   ..| .|.
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvr....Gyddapnsyiaaqvsledsssdfwrtvweq...qsrvivqltdlselGikvcaeyl

PrggvddtvriaskwesPGGANDMTQFPSDLKIEFvNVHKVKDYYTVTDIKLTPTDPLVgpVKTVHHFYFdLWKDMNKPEEVVPIMELCAHSH
|                .  . | |.   |... .    .||| | .. . |   |      . . |...  | . . | |  ... .  . .
P................tketldntslyGdilvtl.kgrevkdryaistlllkrvdkee..srelthywy.kwleaevPaeeaaliamllevr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 51-325 5.9e-52 171.4 In-house 27-264 (274) alignment 
Range on Protein: 51-325
Range on HMM: 27-264/274.0
RNDARNRYVNIMPYERNRVHLKTLSG----NDYINASYVKvnvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYW
..  .||| .|.| |. || |.. |.     .|||| |.|    | . |   |.|||||  .| ..||.| |..   .  ||||.| | | |..|| .|.
gsqtknryktilPnensrvllesessededssyinanyik....GydeeskayvatqGPlpntvadfWrmiyqe...evqvivmltklkeaneqkCavyf

PrggvddtvriaskwespgGAN--DMTQFPSDLKIEFVNVHKVKDyYTVTDIKLTPTDPlvgpVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS-
|                   |.  ....   |..|..... . .| |.|. . |  .       ..|.|...  | |.. |... ....|... .. .. 
P..................daedyeiserygdveikvekivernd.ysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesree

---RGNPIIVHCSAGVGRTGTFIALDHLMHDTLDfknitersrhsdrateEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHAA
   .  |..||||||.|||| ||| .  ...  .                | . |.. .|| .|| .|  ||||..|. .|..| 
enaklapvvvhCsaGiGrtGcfiaisiavrqlre................eivvdvl.kivcnlrldrGGmvqtseqyelihral
subfamily_PTPN13_pd Subfamily PTPN13 51-327 5e-49 162.0 In-house 36-267 (273) alignment 
Range on Protein: 51-327
Range on HMM: 36-267/273.0
RNDARNRYVNIMPYERNRVHLKTLSGndYINASYVKVNVpgqSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRgg
.| ..||| |..||.. ||.|.  .|  |||||..||.|     .   |||.|||  .| . |||| .     .  ||.|||  .| .. || .|||   
enkdknryrnvlPydetrvklgdegg..yinaslikvpv...gkdeyeyiacqGPlPetvkdfwqmvweq...kaeviamvtlekekgkvkchrywPe..

vddtvriaSkwespggANDMTQFPSDLKIEFVNVHKVKDyYTVTDIKLTptDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIV
        |       .|. ..  . |..| ..| | .. ..| .....  |   | .. | |. |  | | . | . ...... |.  .|..   ||.|
........s.......knkklkvsnrlevellkvqkldg.fvvralavk..dsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivv

HCSAGVGRTGTFIALDHLmhdtldfKNITERSRhsdrateeytRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
|||||.||.||.|..| .        .. || .             ...|| .|| ||  .||||||..|.|.|. .
hcsaGiGrsGtlitidvv.......lglierdk..........efdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 51-326 4.5e-46 152.0 In-house 19-261 (270) alignment 
Range on Protein: 51-326
Range on HMM: 19-261/270.0
RNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKvnvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPldnIVIVMVTPLVEYNREKCYQYWP
|. . ||| .|.|  . || |..|. .    |||| ||.    | . |. .|||..||.  |  .||.| ...       |||.|.|.| .|.|| .|||
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvr....GfdgekkkYiaamgPlpttlksfwrmiweekv...taivmttgleEkgrkkCerYWp

RggvddtvriaskweSPGGANDMtqfpSDLKIEFVNVHKVK-DYYTVTDIKLTpTDplvGPVKTVHHFYFDLWKDMNK---------PEEVVPIMELCAH
               .|.   ..    .| ||. ......| . | .| ..|. ..   |  . . ||..  | |            ..... ...   .
a..............epkekvkl....edgkikvlalseekeegyiltrlrle.ek...geerrlvHfwyntWpdhgvpreedsslstdqllkmlravrr

SHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHdTLDfkniteRSRHSDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
|..  ....|..||||||||||||.||||. .. .|.      .... |          . .|. .|| .||..||. .|. |.|.|  
sekeldkaePllvHcsaGvgRtGtlialDiavr.lLe......etkkvd..........vlaiieelRkdRmalvqhpeqyeflykavv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 51-323 5e-29 96.0 In-house 47-281 (305) alignment 
Range on Protein: 51-323
Range on HMM: 47-281/305.0
RNDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKVnvPGqsiEPGYYIATQGPTRKTWDQFWQMCYHNCpLDniVIVMVTPLVEYNREKCYQYWPRGG
..  .||| ..   ..|||.|..    .|| | ||    |    .|  .| || |  ||  .|| ||. .  ..   | |.  |.|   .||..|..   
qeagknrykdvgcldnnrvklegpwpheyihanyvst..pt...npkrfictqaplektcadfwymclqdk.ve..aifmlcnllekgakkcleyfaskd

vDDTVRIASKwespgGANDMTQFPSDLKIEFVNVHKVKdyytVTDIKLTPTDPLVGPVKTvHHFYFDLWKDMNKPEEVVPIMELCAHSHSlnSRGnPIIV
 .|.. .  |     |   . .| |  ...|..  | |    ||. .|.   |     |.  |...  | |   |   . |.|| ... .  |.| ||.|
.kdvlefeek.....gqkisvkfessvtlkfrkdakak....vtetvlviegpgekarkv.thyhwidwpdrgvpaadlailellekarp..skg.pivv

HCSAGVGRTGTFIALDHLMHDTLDFKNITErsrhsdraTeeytrdliEQIVLQLRSQRMKMVQTKDQFLFIYH
|||||.||||. . |...... |  . | .        |        ..|. ..| || . .|| .|.||.. 
hcsagigrtgsvvmleyildqllagqiied........t........dkilqkireqrnnsiqtdaqylfvhq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 51-323 8.3e-29 95.5 In-house 40-271 (307) alignment 
Range on Protein: 51-323
Range on HMM: 40-271/307.0
RNDARNRYVNIMPYERNRVHLKTLS-GNDYINASYVkvnvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRG
 |  .||| ..   ...|. .|.     ||| | |.     | .|.|  .|..|||  .|  .|| |.  .   .   ..|.  ..|  . || ||||  
antdknryqdvkcqdkgrivvkfdglasdyihanyl.....giaikpkkficaqgplentqysfwamaiqe...kvesvimlckvielakikceqywple

GVDDTVrIASKwespGgaNdmTQFPSDLKIEfvNVHKVKDYYTVTDIKLTPTdplvGPVKTVHHFYFDLWKDMNKPEEVVPIMELCahsHSLNSRGNPII
  .  |  ...    .  |  |   ..| ..  ..   .|.  ||..|.  .    .  .|..|. .. | |   |.  .  ..|    .. .   ||..
egqklv.fgea....p..n..tisvanlgak..klapdedlinvttlkvdwa....qksrtiqhlqwenwpdrgvpqinltainll...eavrydtnpvv

VHCSAGVGRTGTFIALDHLMHDTLDFKNITErsrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYH
|||||||||.|| .|.  ..   .. .|  .                ....| .|||||   .||. |.|... 
vhcsaGvGrsGtivaislvqdkmiaGinckd................mkklveelrsqrhyaiqteaqylylhr
subfamily_CG7180_pd Subfamily CG7180 51-323 8.6e-25 82.0 In-house 41-284 (296) alignment 
Range on Protein: 51-323
Range on HMM: 41-284/296.0
RNDARNRYVNIMPYERNRVHLKTLSGN---DYINASYVKvnvpgQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNReKCYQYWP
 |  .||.|...||. ||| |..| |.   |||||.||        . .  || |..|...| |.||.. | .   .   .|..|   .... .. .|||
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvd.....sflkkkeyivteapkketvdefWrlvyde...eisavvvLtktfdfak.mypsywp

RGGVDDTVRIASKWespggaNDMTQFpSDLKIEFVNVHKVkdyytVTDIKlTPTDPLVGPVKTVHHFYFDLWKD-MNKPEEVVPIMELCAHSHSLNSRG-
  .  .   |  .         . |. ..|||  . . |      .  .    . . . ....|..| .  |.   . |     ..||    ...  .  
nkskeqygeifvei......veekqy.anlkirtfkltkk.....ivalt.eqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

-----NPIIVHCSAGVGRTGTFIALDHlmhdtldfkNItersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYH
     .|..|..| |..|.| ..|.|          |.       . . .|   |.  . | .|| .| ..|...... .|| 
edpeegPvvvvssdGasRsGvylaida.........nl.......elvekeeevdvF.eavktlrrsRpqLvenveeYkyiYd
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 51-148 2.1e-23 77.8 In-house 2-93 (237) alignment 
Range on Protein: 51-148
Range on HMM: 2-93/237.0
RNDARNRYVNIMPYERNRVHLKTL-SGNDYINASYVKvnvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
.| ..||| ||. |. .|| ||   || |||||.|.|    |    |  |||.|||   . |.|||| . .      ||||.| |.| |..||..||| 
enkiknrygnivaydhsrvvlkgagsgsdyinatylk....gfdgtpkkyiaaqgplesscddfwqmvwqe...kcsvivmltgliegnelkchkywps
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 51-148 1.8e-18 61.3 In-house 37-128 (287) alignment 
Range on Protein: 51-148
Range on HMM: 37-128/287.0
RNDARNRYVNIMPYERNRVHLK--TLSGNDYINASYVkvnvPGQSIEpGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
 .  .||| ...|.. .|| |   .  | ||||| ||    ..   .   .||.|||   |  .||.. ...      .....|  ||  | |||.||| 
aavkknryadvlPiddtrvllsaegelGsdyinanyv....asytdd.eafiaaqgPiaatvrdfwravlet...rsasvitmtreveearlkcykywPe
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 51-322 2.3e-18 60.8 In-house 51-283 (310) alignment 
Range on Protein: 51-322
Range on HMM: 51-283/310.0
RNDARNRYVNIMPYERNRVHLKTL--SGNDYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNCpldNIVIVMVTPLVEYNREKCYQYWPR
..  .||| ...  .  ||.||      .||| | ||| |   ..     .| .||| ..|  .||.| . .       |...   .|  | ||  ||| 
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrst.....ficsqgplqhtiidfwrmifqer...aesilllckvgeegrpkcvgywps

GGVDDTVRIASkwespggANDMTQFPSDLKIEFVNVHKVKDYYTVTDiklTPTDplvGPVKTVHHFYFDLWKDMNKPEEVVPIMelcAHSHSLNSRGNPI
 || .|              ....   ...|  . |  | |   | .    |..        |    .  | |.  |.| .  .         . |  | 
lgvtetygcir.......vtnlsesseefeicnlavtfvpdnvpvde...qpan...lkelrvslikwpnwpdrgvpdekchtv...pqrllaqvrhgpc

IVHCSAGVGRTGTFIaldhlmhdTLDFKniTERSRHSDRATeeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIY
.||||||..|... .        .|..|   ..... ..         .|... .|. .|.. .||. |.|.| 
vvhcsagkdrlyvvv........alklk..idkldrglkvd.......aeevktellksraiciqtelqyliid
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 51-87 7.2e-08 26.5 In-house 47-83 (95) alignment 
Range on Protein: 51-87
Range on HMM: 47-83/95.0
RNDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKV
 |  .||..||.||.  || | |    ||||| .|  
anipknrflnifpydatrvvlttkrdsdyinacfvdg
Y_phosphatase Protein-tyrosine phosphatase 52-324 4.5e-56 185.3 Pfam-A 1-232 (235) alignment 
Range on Protein: 52-324
Range on HMM: 1-232/235.0
NDARNRYVNIMPYERNRVHLKTLSG-NDYINASYVkvnvPGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPrgg
|  .||| .|.||...||.||  .| .|||||.||     | . |.  .||||||. .| ..||.|....   .  ||||.| |.| .|||| ||||   
nkkknRykdilpydktrvklkgsegpsdYInAnyv....kgyk.ekkkfIatQgPlkstiedFWrmvwqe...kvkvivmltsleekgrekcaqYwp...

vddtvriaskwespgGANDMTQFPSDLKIEFV-NVHKVKDYYTVTDIKLTPTDPLVgPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLN-SRGNPI
                ... ..   |.|.| . .... .. ||.....|. ..      ..|... .  |.| . ||.. ....|.   .. . .. .|.
...............eeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpv

IVHCSAGVGRTGTFIALDHLMHDTLDfknitE-RsrhsdrateeytrDLIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.|||||||||||||.||| |..   .     |                 . ||| .||.||..|||. .|. |.|.|
vVhCsaGvgRtgtfvaldilleqlea.....eee.............vdvlqivkelRkqRpgmvqsleqYiflyka
Y_phosphatase Protein-tyrosine phosphatase 52-324 4.5e-56 185.3 In-house 1-232 (235) alignment 
Range on Protein: 52-324
Range on HMM: 1-232/235.0
NDARNRYVNIMPYERNRVHLKTLSG-NDYINASYVkvnvPGQSiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPrgg
|  .||| .|.||...||.||  .| .|||||.||     | . |.  .||||||. .| ..||.|....   .  ||||.| |.| .|||| ||||   
nkkknRykdilpydktrvklkgsegpsdYInAnyv....kgyk.ekkkfIatQgPlkstiedFWrmvwqe...kvkvivmltsleekgrekcaqYwp...

vddtvriaskwespgGANDMTQFPSDLKIEFV-NVHKVKDYYTVTDIKLTPTDPLVgPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLN-SRGNPI
                ... ..   |.|.| . .... .. ||.....|. ..      ..|... .  |.| . ||.. ....|.   .. . .. .|.
...............eeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpv

IVHCSAGVGRTGTFIALDHLMHDTLDfknitE-RsrhsdrateeytrDLIEQIVLQLRSQRMKMVQTKDQFLFIYHA
.|||||||||||||.||| |..   .     |                 . ||| .||.||..|||. .|. |.|.|
vVhCsaGvgRtgtfvaldilleqlea.....eee.............vdvlqivkelRkqRpgmvqsleqYiflyka
0041856 (Phosphotyrosine protein) phosphatases II 52-327 2.1e-40 133.6 In-house 1-169 (182) alignment 
Range on Protein: 52-327
Range on HMM: 1-169/182.0
NDARNRYVNIMPYERNRvhlktlsGNDYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNcpldNI-VIVMVTplveynrekCYQYWPrgg
|  .|||..|.||...|       ..|||||...  . |..      .||||||. .|. .|..| ...    .| .||..|         ...|||   
nldknrysdilpydhsr.......dldyInanlylgslpatr.....fiatqgpllstvadflrmlkel....gittivnlt.........eelywp...

vddtvriaskwespggandmtQ-FpsdlkiefvnvhkvkdyytvtdikltptdplvgpVKTVHHFYFDLWKDMNKPEevvpIMELCAHSHSLNSRGNPII
                     . .                                   ........  | |.. |.    . ||..  .  ...|.|..
.....................ell..................................erlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCSAGVGRTGTFIALDHLMHDTLDfknitersrhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
||||||||||||..|.. ...  ..                      .|..| ..||.|..||.| .|. |.. |. .
VHCsaGvgRtgtlvaaylmkklgvs......................leeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 52-323 2.7e-26 87.2 In-house 35-264 (285) alignment 
Range on Protein: 52-323
Range on HMM: 35-264/285.0
NDARNRYVNIMPYERNRVHLKTLsGNDYINASYVKVNVPGQSiepgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRGgV
|   ||| ..   |  || ||     ||| ||....    ||     ||.||||  .|  .||.| |..       ..|.  |.|   |||  |.|   .
npdlnryadvrcieetrvvlknh.drdyihaswmrmpgkdqs....tyittqgplpetlsdfwhmiyqe...kiayvlmlctlfeggvekcalyypek.l

DDTVRIaSKWEspggandMTQfpSDLKIEFVNvHKVKDYYTVTDIKLTPTDPLVgpvktVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIVH
 . |..  |.|       .|   .. | | .    . .  ||.. . . ..||      . |     | |   ||.  |..||    . .| . .|| ||
gevvkf.gkye.......itl..teckeeaia.gtilnaltvintedasseply.....mnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvh

CSAGVGRTGTFIALDHLMHDTLDFKNItersrhsdratEeytrdLIeQIVLQLRSQRMKMVQTKDQFLFIYH
|||||||| ||. .|.     ..  ||           |     .. .|| ..|. |.. ||.. ||||.| 
csagvgrtatfvgidyatirimenpni...........e.....ml.divremramrfqavqshmqflflyv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 52-323 1e-22 75.2 In-house 55-283 (305) alignment 
Range on Protein: 52-323
Range on HMM: 55-283/305.0
NDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKVNVpgqsIEPGYYIATQGPTRKTWDQFWQMCYHNCpLDNivIVMVTPLVEYNREKCYQYWPRG-G
. ..||| ..   ... |.|.  |  ||| | || . .    |    .|..|||  .| |.|| |  .|  ...  |||.   ||  . || ||||   |
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpm....ipekrficaqgpldqtidefwwmviqnk.veq..ivmlcktvelgklkcaqywpaaqg

VDDTVRIASKWESPGGANDMTQFPsDLKIEFVNVHkvkdyYTvTDIKLtptdplvgpvkTVHHFYFDLWKDMNKPEEVVPIMELCAhshSLNSRGNPIIV
   ...     |   |.. | . . ...|  .|.      |.  | |.           .| |. .  | |   |   .  .|| .   ..     ||.|
eklelksgivvenvsgskpmerda.eiqitllnlt.....ys.gdqkm...........svrhlqwtewpdrgvppckltslells...airgskvpivv

HCSAGVGRTGTFIALDHLMHdtldfkNITERSRHSDrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYH
|||||.||||| .|.....       .|.|  .             . ..|  || ||   .|.  |.|||. 
hcsagigrtgtivaieyile......kiaenkpcpp..........mpelvkalrdqrafsiqndvqylfihr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 52-326 1.5e-20 68.4 In-house 43-268 (288) alignment 
Range on Protein: 52-326
Range on HMM: 43-268/288.0
NDARNRYVNIMPYERNRVHLKtlsgnDYiNASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRGgV
| .|.|| |.   .  ||.|.     |     |...||   .  .   | .| | . | ...|.|  ..   |   |||.. |.|  .||  .|.|   .
nptrdryenlprcditrvkls.....dd.pdfyiaanvvssakykrrlicaqaPlngtieelWkmlles...dveyivmlcellekGkeksaeyfPsk.l

DDTVRIASKwespggandmtqfPSDLKIEFVNVHKVKDYYTVTDIKLTPTDPlvgpvkTVHHFYFDLWKDMNKPEEVVPIMELCAHShslNSRGNPIIVH
 ...||                 .. | . ....|.    ..   | . .         | . ..  |.|   ||. .. . |.      .|  .||.||
Gekarigrl.............ctvvkkkradidklvkvsllriskegeekv......ivkilhlleWdddgvPenylsplrllevl...kslqkPivvh

CSAGVGRTGTFIaLDhLMhdtldfknITERSRHSDRATeeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
.|||||||||.| |  |.        . |  | .|  .       |.... .|| .|.| .||. |.|...   .
ssaGvGrtgtli.li.li........aleslrlddflg.......irsllaklreerfkaiqtemqylyvhrcvl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 52-148 1.5e-19 65.1 In-house 8-100 (239) alignment 
Range on Protein: 52-148
Range on HMM: 8-100/239.0
NDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKVNvPGqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
| |.||| ||. |...|| |. ||    .|||||||..    |    |  ||||||    .  .||.| ...      ||||.| |.|  ..||.|||| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdy.dg...spkayiatqgcveissgdfwrmmwqe...rrcvivmltglieghkkkchqywpd
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 52-148 1.6e-19 65.0 In-house 7-99 (239) alignment 
Range on Protein: 52-148
Range on HMM: 7-99/239.0
NDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKVNvPGqsiEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
| |.||| ||. |...|| |. ||    .|||||||..    |    |  ||||||    .  .||.| ...      ||||.| |.|  ..||.|||| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdy.dg...spkayiatqgcveissgdfwrmmwqe...rrcvivmltglieghkkkchqywpd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 52-149 3.6e-12 40.5 In-house 48-135 (439) alignment 
Range on Protein: 52-149
Range on HMM: 48-135/439.0
NDARNRYVNIMPYERNRVHLKTLSG---NDYINASYVKvnvpGqSIEPGYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNRekcyqYWPR
....||| .. ...  || |. . |     |||| |.|    |   ..  |||||||...| |.||.. ...     . |||.| |||  .     ||| 
dqtknrykdvgafdhtrvtlqeipgvphshyinanyik....G.yyddklyiatqgpkkettddfwrlviek...ktvtivmltnlvesyk.....ywps

G
 
d
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 52-120 6.8e-06 19.9 In-house 47-106 (303) alignment 
Range on Protein: 52-120
Range on HMM: 47-106/303.0
NDARNRYVNIMPYERNRVHLktlSGNDYINASYVKVNVPGQSiepgyyIATQGPTRKTWDQFWQMCYHN
|  .||.|...  .  .|.|   |   || |||....   ..      | || |  .|  .||||  ..
nmdknrfvdvicldhskvkl...sdssyihasyleldsskka......iltqlplshtaadfwqmiieq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 53-148 8.8e-13 42.5 In-house 55-142 (290) alignment 
Range on Protein: 53-148
Range on HMM: 55-142/290.0
D--ARNRYVNIMPYERNRVHLKTLSGNDYINASYVKvnvpGqsIEPgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
    .||| ...  .. || ||     ||. | |||    |  ...  .| |||....|  ..|.|  ..   .  .|||.  |.|  . || ||.| 
tefkknrykdvvcndktrvilkdGydGdyvhanyvk....G..lka.mfiltqGalkdtvidiwrmvlqe...kvaaivmlceliedGkakceqyype
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 53-162 1e-10 35.5 In-house 49-170 (349) alignment 
Range on Protein: 53-162
Range on HMM: 49-170/349.0
DARNRYVNIMPYERNRVHLKTL-----------------SGNDYINASYVKVnvPGQSIEPgYYIATQGPTRKTWDQFWQMCYHNCpldNIVIVMVTPLV
 |.||| .|.|||  || ||                     .||||| |.|.  .  |.|   ||||| |   | | |...   |      ... ..   
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkl..trisvek.kyiatqaPlPstvddfykvillng...vklvlsLnddk

EYNREKCYQYWPRGGVDD-TVRIASKWE
| . |||..||  .  .. ||..   ..
elslekcdiywqelsysnitvklqnssl
subfamily_eak_pd Subfamily eak 53-152 2.1e-07 24.7 In-house 51-145 (332) alignment 
Range on Protein: 53-152
Range on HMM: 51-145/332.0
D--ARNrYVNIMPYERNRVHLKTLS--GNDYINASYVKVNVPGQSiepgyYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR
.   ||  |.|.||.|. |.| .     . ||||| .. .  |.      || |  .  .    |||| . .       ||..   || . ||  .|.| 
eavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrk.....yiltGiasedkvfafwqmvleq...kspaivqlledvelkleksdkyfpd

GGVD
 . .
ktre
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 55-269 1.8e-17 58.0 In-house 46-233 (312) alignment 
Range on Protein: 55-269
Range on HMM: 46-233/312.0
RNRYVNIMPYERNRVHLKTlSGNDYINASYVKVnvpgqSIEPGYYIATQGPTRKTWDQFWQMCYHncpLDNIVIVMVTPLVEYNREKCYQYwprggVDDT
 ||| ||  ..| |  |     | || | .||.        |  ...||||  .|  .|||..     | .  |.... .||   ||| .|     . | 
lnrypniqcwdrgrftlag.denfyihanfvki.....ctkperfvctqgplentcthfwqlals...lgstsiillcgfvedgsekcaky.....isdi

VRIASKWEspggANDMTQFPSDLKIEfvnvHKVKDYYTVTDIKLTPTdpLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAhshSLNSRGNPIIVHCSA
| .    .        |.. ....|      | ||  |   .|.       |    . |. .  | |   |. .   . | .   ...   .|.| ||||
vgfvdled....hrvyteycteieig....gkskdkithrvlkvvvk..atgqesklnhyqwaswpdhgmpdscdtalrlls...avkkdkkpviahcsa

GVGRTGTFIALDHLM
|||||||.. .. ..
gvgrtgtlaliesmi
0044763 (Phosphotyrosine protein) phosphatases II 63-331 2.2e-27 91.2 In-house 1-173 (178) alignment 
Range on Protein: 63-331
Range on HMM: 1-173/178.0
PYERNRVHLKTLSG---NDYINASYVKvnvpgqsiePGYYIATQGPtRKTWDQFWQMCYHncpldniVIVMVTPLVEYNREKCYQYWPRGGVddtvrias
|..|.||.| .|.|    ||||||..          ||.|.....|  . .......  .       .||..|. .|....||..|||..          
pldrtrvllsnleglersdyinaseil.........pglylgslpp.addlellkelgit.......hivnlteelelgflkcdpywpeeag........

kwespggandmtqfpsdlkiefvnvhkvkdyytvtdikltptdplvgpvktVHHFYFdLWKDMNKPEEVVPIMELCAHSHSLN-SRGNPIIVHCSAGVGR
                                                   ......  . |.. |.    ..|...  ...  ..|.|..|||||||||
...................................................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgR

TGTFIALDHLMHDTLDFKNitersrhsdrateeytrdlieqIVLQLRSQRMkMVQTKDQFLFIYHAAKYLNSL
.||..|.. ...  |.. .                      .. ..|..|. .|.. .|  ..|  ...|.. 
sgtlvaaylmkklglslee......................aielvrerRp.ivpnpgqlrqLyefelrllke
0051429 (Phosphotyrosine protein) phosphatases II 74-327 9.6e-40 132.3 In-house 1-223 (272) alignment 
Range on Protein: 74-327
Range on HMM: 1-223/272.0
LSGNDYINASYVKVNvpGQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPldniVIVMVTPLVEYNREKCYQYWprggvddtVRIASKWESPGGANDMTQF
|. ..||||..|. .  |. . ||......||.. |...||... ...     .||......|..|.||..||          |   . .  .  ..| .
lplsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrlkelgik....tivdLrseeErgrlkcdryw........pgirylhlpilddsaptil

PSDLKIEFVNVHkVKDYYTVTDIKLTPTDPLVGPvKTVHHFYFDLWKDMNKP-EEVVPIMELCAHshslnsrGNPIIVHCSAGVGRTGTFIALDHLMhDT
  .| . .. .. ....|... . || . .   .  .|.|...  | |.. | |... ..||...       |.|..||||||..||||..||..|.   
ygalrvtllsee.llldyilrellltlllsagea.revmhlhytdwpdhgvpqeallellellld.......ggpvlvHCsaGkdRTGtvvalllll.lg

LDFKNITERSRHSDRAteeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
..   | .  . .. .        .|..| .||.||...||| .|.||.|.|.. 
vsletivddYlltnly........leeaveelraqrpgavqteeqylflyealle
0036282 (Phosphotyrosine protein) phosphatases II 76-324 2.9e-36 120.1 In-house 1-165 (174) alignment 
Range on Protein: 76-324
Range on HMM: 1-165/174.0
GNDYINASYVKVNVPGQsiepgYYIATQGPTRktwdqFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRggvddtvriaskwespggandmtqfps
|.||||||......        ..||.|||..     ||.|....   .  ..||.....| ...||..|||.                           
gsdyinaspldlsyitp.....rliagqgpla.....fwemlkel...gittvvmlleekelglykcinywpe...........................

dlkiefvnvhkvkdyytvtdikltptdPLVGPVKTVHHFYFDLWKDMNKPEEVVpIMELCAHSHSLNSR--GNPIIVHCSAGVGRTGTFIALDHLMHDTL
                               ..........  | |.. |.  . . |..   ..  |.  |.|..||||||||||||..|.. ...  |
...........................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll

-DFKNItersrhsdrateeytrdliEQIVLQLRSQRMKMVQTKDQFLFIYHA
 .. ..                    ..| .||.||..|||| .|. |.|  
eslvda...................ldlvrelRlqrpgmvqtpsQyrflyyf
0046846 (Phosphotyrosine protein) phosphatases II 76-328 1.5e-32 108.2 In-house 11-172 (176) alignment 
Range on Protein: 76-328
Range on HMM: 11-172/176.0
GNDYINASYVKVNvpgqsiepgYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPR----GGvddtvriaskwespggandmt
. |||||...  .         ..||||||...|  .|..| ...   .  ..|..| .||..| ||..|||.    |                      
dldyinanlilgs.........rpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgi.....................

qfpsdlkiefvnvhkvkdyytvtdikltptdplvgpvktvhHFYFDLWKDMNKPEEvVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLmhd
                                         ....  | |.. |.    ..||..  ..  ..|.|..||||||.|||||..|.. |   
.........................................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayll...

tldfknitersrhsdrateE--YTRDLiEQIVLQLRSQRM-KMVQTKDQFLFIYHAAKYL
                   |  .  .. |... ..|.||. ..||| .|  |.|.....|
...................elekglsv.eealalvreqRplgavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 76-328 1.8e-31 104.6 In-house 4-160 (172) alignment 
Range on Protein: 76-328
Range on HMM: 4-160/172.0
GNDYINASYVKVNVpgqsiEPGYYIATQGPTRKTWDQFWQMCYHNCPLDnivIVMVTPLveynrekcyqywprggvddtvriaskwespggandmtqfps
|.|||||||.....      |  .||||||.| |...||.|....       ||..|.|                                         
gsdyinasyldlyy.....ipdrfiatqgplrntladfwrmlkelgith...ivnltel.........................................

dlkiefvnvhkvkdyytvtdikltpTDPLVGPVKTVHHFYFDLWKDMNKPeEVVPIMELCAHSHS--LNSRGNPIIVHCSAGVGRTGTFIALDHLMhdtL
                         . .  . .... ....  | |.. |     ..|..   ..  ..|.|.|..||||||||||||..|.. ..   |
.........................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml...l

DFknitersrhsdrateeytrdLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
..                     .|..| ..|..|...||...|  |.|. .|.|
gl....................sleeavalvrekRpgavqnpsqyrflyyfekll
0051082 (Phosphotyrosine protein) phosphatases II 77-324 8.8e-27 89.0 In-house 3-148 (151) alignment 
Range on Protein: 77-324
Range on HMM: 3-148/151.0
NDYINASYVKvnvpgqsiepGYYIATQGPTRktwdQFWQMCYHncpLDNIVIVMVTPLVEYNreKCYQYWPRGGvddtvriaskwespggandmtqfpsd
.||||.|||           |......||.     .|... ..   |.  .||......|..  .|..|.|. |                          
sdyinfsyvt..........gglyrsggpla....dflellke...lgiktivnlrseeerg..ycpeylpelg..........................

lkiefvnvhkvkdyytvtdikltptdplvgpvKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSlnSRGNPIIVHCSAGVGRTGTFIALDHLMHDtldfk
                                 .|.|.... |.| . |.    ..|.  .  .   ...|..||||||.|||||..||. ....     
................................ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylmllg.....

nitersrhsdrateeytrDLIEQIVLQLRSQRMKMVQTKDQFLFIYHA
                    .|... ..|..|. .||...||||...|
..................vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 94-320 2.9e-18 60.6 In-house 87-272 (301) alignment 
Range on Protein: 94-320
Range on HMM: 87-272/301.0
IEPGYYIATQGPTRKTWDQFWQMCYHNcPLDNivIVMVTPLVEYNREKCYQYWPRGGVddtvriaskwespggaN--DMTQFpsDLKIEFVNVhKVKDYY
 .|  .|||||| ..| . || |. .   ...  |||..  ||.. ||| .| |                    .  |. .|  ..||.  ..  ...  
GhphrfiatqgPlkntsedfwamlvqy.dvek..ivmlgqkvekleekceeylpvkis................ekldigrf..kikiknkel.ilnkki

TVTDIKLTPTDPLVgPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHshsLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLdfknitersrhSDRATEe
.   .... .   . . .|| |. .  | | . |.  . ...|      .    .||.||||||.||. .||. . | .. .           .|.  | 
skrtlevedstgkf.atrtvthyqysewtdrgvPkshaelfdlmel...vkksekPivvhcsaGiGrsvafigteylareve...........adptie.

ytrdlIEQIVLQLRSQRMKMVQTKDQFLF
     . . . .|| .| . |||. |. .
.....ltealkhlrehrwngvqtnsqlyw
0049260 (Phosphotyrosine protein) phosphatases II 97-328 1.3e-28 95.0 In-house 9-149 (152) alignment 
Range on Protein: 97-328
Range on HMM: 9-149/152.0
GYYIATQGPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWprggvddtvriaskwespggandmtqfpsdlkiefvnvhkvkdyytvtdi
 ..||||||.. |...||.| ...   .  .|||.| |.| ...||.||.                                                  
fefiatqgpgpntladfwrmlkel...gittivmltellelgklkceqyi..................................................

kltptdplvgpvktvhHFYFDLWKDMNKPEEVVPIMELCAHSHS-LNSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfKNitersrhsdrateeytrD
                ....  | |.. |.    ...|.   .  . ..|.|..||||||||||||..|.. ..      ..                  
................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lg.................v

LIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
 .|..| ..|..|...|....|  |.|  .|.|
sleeavalvrekRpgavpnpgqlrflyefekll
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 98-267 5e-12 40.4 In-house 5-156 (198) alignment 
Range on Protein: 98-267
Range on HMM: 5-156/198.0
YYIATQGPTRKTWDQFWQMCYHNCpldNIVIVMVTPLvEYNREKCY-QYWPRggvddTVRIASKWESpggandMTqfpsdlkIEfVNVHKVKDYYTVTDI
 ||||| | |.|  .|||| .         ||||    . |.|  |  |||      |   ..|. |      ..       .  ...  .|  ||.| .
ryiatqhplretladfwqmvwetg...sghivmvndd.qknkeadypfywpt.....tesgtgkygs......ls.......vt.tktittkpdytital

KLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAhSHSL-----NSRGNPIIVHCSAGVGRTGTFIALDH
 ||         . . |. |  ||.   |.  . .  . | |  .     . .  |.||||| | | || |.||| 
iltnnttappstreishyqftswkekttpnvalfvgfvva.srevskkyeqekdapvivhcsdgqgftgvfvaldi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 98-267 6.8e-12 40.0 In-house 6-157 (199) alignment 
Range on Protein: 98-267
Range on HMM: 6-157/199.0
YYIATQGPTRKTWDQFWQMCYHNCpldNIVIVMVTPLvEYNREKCY-QYWPRggvddTVRIASKWESpggandMTqfpsdlkIEfVNVHKVKDYYTVTDI
 ||||| | |.|  .|||| .         ||||    . |.|  |  |||      |   ..|. |      ..       .  ...  .|  ||.| .
ryiatqhplretmadfwqmvwetg...sghivmvndd.qknkeadypfywpt.....tesgtgkygs......ls.......vt.tktittkpdytital

KLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAhSHSL-----NSRGNPIIVHCSAGVGRTGTFIALDH
 ||         . . |. |  ||.   |.  . .  . | |  .     . .  |.||||| | | || |.||| 
iltnnttappstreishyqftswkekttpnvalfvgfvva.srevskkyeqekdapvivhcsdgqgftgvfvaldi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 104-268 2.8e-11 37.4 In-house 98-244 (302) alignment 
Range on Protein: 104-268
Range on HMM: 98-244/302.0
GPTRKTWDQFWQMCYHNcplDNIVIVMVTPLVEYNREKCYQYWPRgGVDDTVRIASKwespggANDMTQFPSDLKiEFVNvhkvKDYYTVTDIKLTPTDP
 | ..| ...| .  .    .  ..| .. .|| . .|| .|.    |.....          .    .   ||. || .    |  ...  .... .  
vpkkstlekhwalieqy...nvaivvqlcsfvedeekkcaeyysd.kvggelkfgry......tvktvsvktdle.eftd....kksfklytveiknekk

LVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNsrgNPIIVHCSAGVGRTGTFIALDHL
     |||. ..|  | |   |.|  . ...  .  |     . ..||||||||||||..|. . 
kkkvkktvdilafsawpdhGapkeaytaldilkfcesyk...knvlvhcsaGvGrtGtlvaikyG
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 176-325 1.1e-24 82.1 In-house 145-276 (318) alignment 
Range on Protein: 176-325
Range on HMM: 145-276/318.0
DLKIEFVNVHKVkDYYTVTDIKLTPTDplVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLN--SRGNPIIVHCSAGVGRTGTFIALDHLMhdtl
.|..|  .  .. ..|..  .|.| |.  .  ...|. . .  | | . ||... ...|  .... .  |  .||.|||||||||||.|||.| |.    
klvvelkeevel.sdyvlrefkvtrte..eeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdill....

dfknitersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHAA
            .|. .| . |.  |.| |||.||  ||||.||. |||.. 
............erikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 176-329 2e-14 48.3 In-house 142-279 (287) alignment 
Range on Protein: 176-329
Range on HMM: 142-279/287.0
DLKIEFVNVHkVKDYYTVTDIKLTPTDpLVGPVKTVHHFYFDLWKDMNK-PEEVVPIMELCAHSHSLNSRGN-PIIVHCSAGVGRTGTFIALDHlmhdTL
. .||..| . |.. |.. ..... ..   |. ..|. . .  |..  | .|    .. .    ..   ||| .|.||||..|||...|.| .     |.
eyniellnee.vnagyierklevknkn.kagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaat....ti

dfknitersrhsDRATEEYTRDLIeQIVLQLRSQRMKMVQTKDQFLFIYHAA-KYLN
            ... .| . |.. |.. . | |....||| .|. ||...  .||.
............nkckteGviDvf.qvlksqriqkpgsvqtveqykfindivleyld
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 181-328 8.1e-09 29.3 In-house 152-284 (302) alignment 
Range on Protein: 181-328
Range on HMM: 152-284/302.0
FVNVHKVKDYYTVT---DIKLTPTDPLVGPVKTVHHFyfDLWKDMNKPEEVVPIMELCAHSHSLNSRGN-PIIVHCSAGVGRTGTFIALDHLMHdTLdfk
|||. ||.     .    | . | .    .. .| ..  . ||. . |...  ...  |. . ... .. ....    |.|| |.|..|   .. .|   
fvNnrkVekaeeektryviEvlPegcsnsvlanvyvl..tnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave.kl...

niTERS--RhsdrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
  .. .  .             |..|| ..|||| ..|.. .|. ..| |. ..
..qkgkepn.............ikeivksiRsqRpravdslkQyvslyiallly
0048179 (Phosphotyrosine protein) phosphatases II 187-327 6.8e-21 69.9 In-house 25-143 (144) alignment 
Range on Protein: 187-327
Range on HMM: 25-143/144.0
VKDYYTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsd
 |..   | | ||.. .   . ........  | |.. |.    . |...  ... ..|.|..||||||||||||..|.. ..                 
lkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.................

rateEYTRDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKY
    ..  . .|... ..||.|. .|.. .|. |..   |.
....klgls.leealalvrsrrpgavpnpgqlrfLleyekl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 191-323 1.3e-10 35.9 In-house 116-233 (237) alignment 
Range on Protein: 191-323
Range on HMM: 116-233/237.0
YTVTDIKLTPTDPLVgPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHS--HS-LNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNItersrhsDr
|||  . |.    |   |. .| . |  | |   |..   .. .  .   .|   |.  | |.|||||||||| |. .| ..... . | .       | 
ytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvv.......d.

ateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYH
         | . |  .  .|  ..|||||..||..
.........iynyvysieedrpyiiqtkdqyvfihq
0048076 (Phosphotyrosine protein) phosphatases II 194-328 4.8e-21 70.4 In-house 34-142 (145) alignment 
Range on Protein: 194-328
Range on HMM: 34-142/145.0
TDIkltpTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHdtldfknitersrhsdrateeYT
 ..    |. | ...... ....  | |.. |.    ..|...  ... ..|.|..||||||||||||..|.. ...                     . 
lnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....................lg

RDlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYL
 . .|... ..||||...|.. .|. |.| . ..|
vs.leealelvrsqrpgavpnpgqlrflyefelel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 206-278 5.9e-10 33.3 In-house 180-249 (290) alignment 
Range on Protein: 206-278
Range on HMM: 180-249/290.0
GPVKTVHHFYFDLWKDMNKPEEVVPIMELcahSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNI
|  . ..|.    | |   .   . .. .    ..|     |..||||||.||||||.|..  .   || |..
Gkehklkhlkikswpdksvalstlallrt...lrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 206-323 6.1e-09 29.9 In-house 164-263 (281) alignment 
Range on Protein: 206-323
Range on HMM: 164-263/281.0
GPVKTVHHFYFDLWKDMNKPEEVVPIMELCahsHSLNSRGNPIIVHCSAGVGRTGTFIALDhlmhdtldfknITERSRHSDrateeYTRDLIEQIVLQLR
|  . . |. .  | | . ||    ....    . . .|  | ..||||||||.||..|..           |. .| ||      .|   |.||| .||
getrlithwlwkewpdwqvpessevmlkil...rkirarstppvihcsagvgrsgtlmave...........ialqsihsh.....ftlpdikqivshlr

S-QRMKMVQTKDQFLFIYH
   |   ||| .|...|..
vtgraasvqtlqqymliwk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 207-324 8.3e-23 75.8 In-house 173-274 (288) alignment 
Range on Protein: 207-324
Range on HMM: 173-274/288.0
PVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRG-NPIIVHCSAGVGRTGTFIALDHLMHDTLDfknitersrhsdrateEYTRDLIeQIVLQLR
   ..... .  | |.. ||   |..||    .  |.   .|||||||||||||||||||| |..                    | . |..  .| .||
teleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee................edyiDva.gtvaklR

SQRMKMVQTKDQFLFIYHA
 ||. .|||. |. |||..
kqRallvqtlkqYefiyev
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 207-324 1.1e-17 58.9 In-house 173-274 (315) alignment 
Range on Protein: 207-324
Range on HMM: 173-274/315.0
PVKTVHHFYFDLWKDMNKPEEVVPIMELCA--HSHSLNSRgNPIIVHCSAGVGRTGTFIALDHLMhdtldfknitersrhsDRATEEYTRDLIeQIVLQL
 ...|  . .  | ||. |.  .|.|.|    . |  ||   .|.||||||||||||||.|| ..                |.|  |   |.  ... ..
nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavl................dqaeaenaidvy.nfitgv

RSQRMKMVQTKDQFLFIYHA
|..|.||||. .|. ||| |
rqnrikmvqvaeqyqfiyda
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 207-324 1.9e-15 51.3 In-house 172-274 (439) alignment 
Range on Protein: 207-324
Range on HMM: 172-274/439.0
PVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS--RGNPIIVHCSAGVGRTGTFIALDHLMHdTLDFKNitersrHSDrateeytrdlIEQIVLQL
  .|| .|..  | | | | .   ....     | |      |..|||||||||||| ||||  .   |  .|      . |          |. ||  |
kertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdiale.qlklen......kvd..........ikgivkvl

RSQRMKMVQTKDQFLFIYHA
| || .|||.  |..||| |
rkqrkqmvqalcqyvfiyna
subfamily_PTPRN_pd Subfamily PTPRN 207-324 2.1e-15 51.2 In-house 185-287 (297) alignment 
Range on Protein: 207-324
Range on HMM: 185-287/297.0
PVKTVHHFYFDLWKDMNKPEEVVPIMELCAH-SHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHdtldfkNITERSRHSDrateeytrdlIEQIVLQLR
  .||  |.|  |.... | .  ...|.      |   |  ||.||||.|.||||..|..| ...      ...   .. |          |   .  ||
etrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvln......rllkGvkeid..........iaatlehlr

SQRMKMVQTKDQFLFIYHA
 || ..|.||||| |.. |
dqrpglvktkdqfefalta
subfamily_hpo-7_pd Subfamily hpo-7 208-271 7.2e-07 23.4 In-house 121-180 (263) alignment 
Range on Protein: 208-271
Range on HMM: 121-180/263.0
VKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHslNSrgNPIIVHCSAGVGRTGTFIALDHLMHD
..||.|. . .| . | ||.   |...       ||   ...||||.|.||.  |   . .   
thtvkhysykgWiekndpelareilnilkvar..ns..kslvvhcstGiGrsaafsvaElvyqk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 209-325 2.7e-09 30.9 In-house 89-190 (440) alignment 
Range on Protein: 209-325
Range on HMM: 89-190/440.0
KTVHHFYFDLWKDMNKPEEVVPIMELCAHS-HSLNSRGN-PIIVHCSAGVGRTGTFIALDHLMHDTldfknitersRHSDRAteeytrDlIEQIVLQLRS
.|....... | |   |. . |....     .| .  || |..||||||.||||  ||.| .....          ..||.       | |  ..  .|.
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilrea..........krsdqi......d.ifsfinsmrn

QRMKMVQTKDQFLFIYHAA
.| .|||| .|. |...| 
nrpqmvqtpeqyafvheav
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 209-315 7.7e-08 26.7 In-house 116-207 (255) alignment 
Range on Protein: 209-315
Range on HMM: 116-207/255.0
KTVHHFYFDLWKDMNKPEEVVPIMELCAHSHslNSrgNPIIVHCSAGVGRTGTFIaldhlmhdtlD----FKNITERSRHSDRATEEYtRDLIEqivlQL
.||.|. .  | . | ||.   |...    .  .|   ...||||.|.||. .|.               ....    . .. .  .| . |.|    .|
htvkhysykGWieknaPelareilnilkvvr..ds..ksvvvhCstGiGrsaafv..........laelvyqkmirsldttetveldy.lslle....el

RSQRMKMVQTK
||.| . ..| 
rskrkraihtP
PTPc_DSPc_SM00012 210-326 3.6e-34 112.5 In-house 1-104 (105) alignment 
Range on Protein: 210-326
Range on HMM: 1-104/105.0
TVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSR---GNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKnitersrhsdrateeyTRDLIEQIVLQLRS
||.|...  |.|...|||. .|.||... .. ..    ..|..|||||||||||||.||| |...  . .                ... |.||| .||.
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket................kevdifqivkelrk

QRMKMVQTKDQFLFIYHAAK
||..||||..|.||.|.| .
qRpgmvqteeqylflyrall
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 210-324 1.8e-10 35.4 In-house 138-236 (239) alignment 
Range on Protein: 210-324
Range on HMM: 138-236/239.0
TVHHFYFDLWKDMNKPEEVVPIMELCAHS--HSLNsRGNPIIVHCSAGVGRTGTFIALDHLMHDtldfknitersrhsdrATEEYTRDLIEqIVLQLRSQ
 |....| .| |   |.    .. |  .    ||     | ..||||||||||.|. .| ....                | .. | |...  |  .| .
yvyqyhftvwpdkgvpqyatavlglrrkitkdslp.garpwvihcsagvgrtgaflvidamlrq................akkqktvdifn.yvkaired

RMKMVQTKDQFLFIYHA
| .|||| .|..||. |
rphmvqtseqyvfihla
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 210-324 1.8e-10 35.4 In-house 137-235 (239) alignment 
Range on Protein: 210-324
Range on HMM: 137-235/239.0
TVHHFYFDLWKDMNKPEEVVPIMELCAHS--HSLNsRGNPIIVHCSAGVGRTGTFIALDHLMHDtldfknitersrhsdrATEEYTRDLIEqIVLQLRSQ
 |....| .| |   |.    .. |  .    ||     | ..||||||||||.|. .| ....                | .. | |...  |  .| .
yvyqyhftvwpdkgvpqyatavlglrrkitkdslp.garpwvihcsagvgrtgaflvidamlrq................akkqktvdifn.yvkaired

RMKMVQTKDQFLFIYHA
| .|||| .|..||. |
rphmvqtseqyvfihla
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 210-266 2.3e-06 22.0 In-house 159-212 (290) alignment 
Range on Protein: 210-266
Range on HMM: 159-212/290.0
TVHHFYFDLWKDMNKPEEVVPIMELCahsHSLNSRGNPIIVHCSAGVGRTGTFIALD
|| |  .  |...| .|.   ...|    . .. .. |.||||  |. |  .. |..
tvtHsllkgWnklnvqedtktllsli...qkvkasktpvivHcvdGiSrsAalaaii
0048567 (Phosphotyrosine protein) phosphatases II 212-267 1e-06 23.2 In-house 31-99 (157) alignment 
Range on Protein: 212-267
Range on HMM: 31-99/157.0
HH-------FYFDLWKDMNkPEEVVPIMELCAHSHSLNS----RGNPIIVHCSAGV---GRTGTFIALDH
..       .|.|.. |   | ..  ..... . ... .    .|..|.|||.||    |||.|.|..  
lyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYl
0038934 (Phosphotyrosine protein) phosphatases II 224-265 9.5e-08 27.4 In-house 95-135 (194) alignment 
Range on Protein: 224-265
Range on HMM: 95-135/194.0
KPEEVVPIMELCAHSHsLNSRGNPIIVHCSAGVGRTGTFIAL
  | .  ...|. . .  .. |. . ||| ||.|||||..| 
sleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaa
PTEN_1 232-264 1.6e-07 26.3 In-house 117-149 (196) alignment 
Range on Protein: 232-264
Range on HMM: 117-149/196.0
MELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIA
 . .... .....|| ..||| ||.||.|| .|
cksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 233-325 1.6e-16 54.6 In-house 253-340 (349) alignment 
Range on Protein: 233-325
Range on HMM: 253-340/349.0
ELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHdtlDFKNITERSRHSDraTEEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAA
.| |. .  ... ....|||||| ||||... || |.     ..  .. |   .   .  ..|||  || .|| ||. |||   || .||.| 
dlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls...ileplqnesnkik..lqallkDlisiivnelrkqrismvqnlaqfiaiyeal
PTPc_motif_SM00404 239-271 2e-06 22.8 In-house 74-106 (140) alignment 
Range on Protein: 239-271
Range on HMM: 74-106/140.0
HSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHD
.. ...|  ..||| ||| |..|.|.   .. .
enaekkggkvlVHCqaGvSRSatliiaYlmryr
DSPc Dual specificity phosphatase, catalytic domain 239-270 2.9e-06 22.2 Pfam-A 67-97 (133) alignment 
Range on Protein: 239-270
Range on HMM: 67-97/133.0
HSLNSRGNPIIVHCSAGVGRTGTFIAlDHLMH
... ..|. ..||| ||. |..|.|.  .|| 
ekaeqkgkkvlVHCqaGisRSatlii.aYlmk
DSPc Dual specificity phosphatase, catalytic domain 239-270 2.9e-06 22.2 In-house 67-97 (133) alignment 
Range on Protein: 239-270
Range on HMM: 67-97/133.0
HSLNSRGNPIIVHCSAGVGRTGTFIAlDHLMH
... ..|. ..||| ||. |..|.|.  .|| 
ekaeqkgkkvlVHCqaGisRSatlii.aYlmk
subfamily_CG42327_pd Subfamily CG42327 243-326 1.3e-11 38.7 In-house 245-312 (319) alignment 
Range on Protein: 243-326
Range on HMM: 245-312/319.0
SRGNPIIVHCSAGVGRTGTFIALDHLMHDtLdfknitERSRHS-DrateeytrdlIEQIVLQLRSQRMKMVQTKDQFLFIYHAAK
..  |..|||| ||||||. || |  ..  |      | |..| |          | |.| ..| .| . |.||.|. |||. . 
esqGPlvvhcsdGvGrtGlviasdiairs.l......eeskrsvd..........iPqlvssvrrdrasavltkeqyefiykvls
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 243-325 2.3e-09 31.6 In-house 226-291 (297) alignment 
Range on Protein: 243-325
Range on HMM: 226-291/297.0
SRGNPIIVHCSAGVGRTGTFIALDHLMhdtldfkNITERSRHSDRATeeytrdlieqIVLQLRSQRMKMVQTKDQFLFIYHAA
 |  ...|||||||||.|  .  | ..       ... . |  | |.          |. .||.|| ..||| .|| ..|.|.
prnayllvhcsaGvGrsGvvvlsdvil.......aklrkkripdvaa..........ilsilreqrarlvqtleqfellydav
subfamily_PTPDC1_pd Subfamily PTPDC1 243-299 5.4e-06 21.0 In-house 113-167 (182) alignment 
Range on Protein: 243-299
Range on HMM: 113-167/182.0
SRGnPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITERSRhSDRATEEYTRDLIEQ
..|  . ||| || ||||  ||   . .. |. ..  .  | | |.   .||. .| 
qeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvr.skrpksiqtreqvel
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 244-325 1.8e-07 25.3 In-house 209-273 (287) alignment 
Range on Protein: 244-325
Range on HMM: 209-273/287.0
RGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNItersrhsDRAteeytrdlieQIVLQLRSQRMKMVQTKDQFLFIYHAA
   |..||...|.||.|...|.  |..  .|  ..       | |          ..|..|| .|  .||.  |. ..| | 
evGPlvvhddvGiGrsGillatlvlvsrledlGrv.......dva..........avvirlreyraalvqavvqlrllyeal
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 244-265 2.7e-06 21.3 In-house 225-246 (301) alignment 
Range on Protein: 244-265
Range on HMM: 225-246/301.0
RGNPIIVHCSAGVGRTGTFIAL
 | |..||||..|.|.|.....
gggpvvVHCSdtVsrsGvYcsv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 249-265 8e-06 20.2 In-house 2-18 (69) alignment 
Range on Protein: 249-265
Range on HMM: 2-18/69.0
IVHCSAGVGRTGTFIAL
.||||.| ||||||||.
vvhcssgtgrtgtfiai