Gene PTP3 in Saccharomyces cerevisiae

Synonym: YER075C, PTP3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Fungi-PTP2
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP023_AA protein Get Run
ScerP023_AA_529-875 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 103-224 2e-15 49.3 Pfam-A 5-111 (113) alignment 
Range on Protein: 103-224
Range on HMM: 5-111/113.0
LGKIIetlPDEKVLLLDVRPFTEHAKSIITNSIHVCLPSTLLRRKNFTFSKLLDNLTPSEQSVLKSKlaidnlRIIIYDSTANQTESSVSLPCYGIASKl
| . .    .|||.|||||.. |.||. |.....|.|.|.  ||..|. .|| ..|  |.... |.|      ....|... |...   .|... | .. 
lkell...ekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdk......tvvvycrsgnrsggaaalllalilke.

IEFDtnvkkTVSILMCGFPQFK
. ..     .|..|  || ..|
lgyk.....nvyvLdGGfeawk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 480-884 4e-192 632.1 In-house 1-349 (349) alignment 
Range on Protein: 480-884
Range on HMM: 1-349/349.0
FPDVNKVQKRSHSQPIFTQYSKYKSMLSLESDSDSESDDVIISSGVELGAKNRYKDIFPYEHSRVILKKGLQSSKGIKHSHSTSDGGILDNYINANYLSL
..|..||||||....|.|.|||.|||||||||.|||.||||.|.||||.||||||||.|||||||.|||.|.|||.||.|.|.||.|.||.|||||||.|
ssdkskvqkrsklkliitkysksksmlslesdddseiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkl

PRFSVEQnssfqttttttrrvRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIHVKLlekkilkmpsttsmrkntmgt
.|.|||.              .|||||||.||||.|||..||.|||.|||||..|.|...|||..||||..|..|.|||                     
trisvek..............kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvkl.....................

QNSSLYSAGVQGNSSNYSTDNDNDNDNNNNNNNnsniavtaaaCDDDDDDDDDAILIrkilltyhDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVK
||||||.|.|||||...||..|.||||.||..|          ||..|||||||||.        ..||||||||.|||||.||..||||||||||..||
qnsslyianvqGnslrvstvkdtdndndnnkkn..........Cdlpddddddaill........avekPyellqlqvknwldlslllnPisilqalevk

NHIIDTLFARNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILSnfeMFEMLQKEFVKLKYPAKLFDPISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
|..||.||||.|...|||.|.||||||||||||.|.|.|..||   ..|.||.|..|.|..|.|.|.||...|..||||||||||..|||.||..||.||
ndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls...ileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

RLRLD
.|..|
alkkd
0039614 (Phosphotyrosine protein) phosphatases II 480-665 2.3e-28 94.9 In-house 19-167 (297) alignment 
Range on Protein: 480-665
Range on HMM: 19-167/297.0
FPDVNKVQKRSHSQPIFTQYSKYKSMLSlesdsdsesdDVIISSGVELGAKNRYKDIFPYEHSRVILKKGLqsskgikhshstsdgG--ILDNYINANYL
.. .... |.. .. ..... ...|.            |  |.  .| . |||||||.||.||||.||                  |    ..||||.|.
ldlllllekansktllllefeellslkp..........dysiallpenkdknrykdilpydhsrvklkped...............gvdldsdYinAsyv

SLPRFsveqnssfqttttttRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIeKCYRYW--QEGNYNGIHVKLLEKKILK
. ...               .  ..||||.|.|.||.||.  . ..||. ...||. .|.|  ||..||   .|.|....|.||. . |.
dgydl...............ltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehld
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 481-885 7.7e-183 602.0 In-house 1-350 (350) alignment 
Range on Protein: 481-885
Range on HMM: 1-350/350.0
PDVNKVQKRSHSQPIFTQYSKYKSMLSLESDSDSESDDVIISSGVELGAKNRYKDIFPYEHSRVILKKGLQSSKGIKHSHSTSDggildnYINANYLSLP
.|..||||||....|.|..|..||.|||||||.|.|.|||.|.||||.||||||.|.|||||||.|||.|.||...|||.||.|      |||||||.|.
sdkskvqkrsklkliitknstvksrlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnD......YinanYlklt

RFSVEQNSSFqttttttrrvRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIHVKLlekkilkmpstTSMRKNTMGTQ
|||||.|..|          .|||||||.||||.|||..||.|.|...||||.|.|...||||||||||.|..|.|||           .|...|.||..
rfsveinpdf..........kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvkl...........askwenimgin

NSSLYSAGVQGNSSnystDNDNDNDNNNNNNNNSNIAVTAAACDddddddddailirkilltyhdqekPYELLQIQVKNWPDLGTLLNPISILQAINVKN
.||||||.|....|    ||||..|.|....|||..|.|.||.|                        ||...|.|||||.||..||||.|||||..|||
dsslysadvkkeas....dndnisddndlkdnnsltaitlaasd........................PyvvyqlqvknWkDlslllnPesilqalevkn

HIIDTLFARNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQKEFVKLKYPAKLFDPISWTINIFRKQRISMVQNINQFIFIYDCLLFYFR
..||.|||.....|.....||||||||.||||||.|.||.||.||..|.|.||..||...||..|.||...|..||||||||||..||||||..|||||.
dliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfa

LRLDD
||.|.
Lrkdi
0045450 (Phosphotyrosine protein) phosphatases II 486-879 1.4e-53 178.0 In-house 20-304 (307) alignment 
Range on Protein: 486-879
Range on HMM: 20-304/307.0
VQKRSHSQPIFTQYSKYKSMLSLEsdsdseSDDVIISSGVELGAKNRYKDIFPYEHSRVILKKGLQSSKGIKhshstsdggildnYINANYLSLPRFSve
...... . .. .. | .|.          ...  |.. .| . |||||||.||.|.||.|.   .|...               ||||.|  .|..   
lllldfltgllkefekllsvtvfl......lgeysiallpenkdknrykdilpydhtRVklssldgsledsd.............YiNAsyvrvplll..

qnssfqTTTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEG----NYNGIHVKLLekkilkmpsttsmrkntmgtqn
      .. .  .  ..||||.|.|.||.||.  . ..|| ....||...|.| |||..|| .     .|. ..|.||                      
......lldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtll......................

sslysagvqgnssnystdndndndnnnnnnnnsniavtaaacdddDDDDDDAILIRKILLTYH-DQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKN
                                             . . .| . .|.. .|..   ... .. ... ..||| |.  .. ..|. |.  .
.............................................seehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

HIIDTlfarnyyqNDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEM---LQkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLF
.....        ...   .|||||||.|||||..... .|...|  ..   .                .  ... .|.||  .||| .|..|.|..||.
kalee........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd...............lleavkllreqRpgavqnpeqyrflyealle

YF
..
ll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 487-662 3.3e-17 57.7 In-house 18-164 (298) alignment 
Range on Protein: 487-662
Range on HMM: 18-164/298.0
QKRSHSQPIFTQYSKYKSMLSLESdsDSESDDVIISSGVELGAKNRYKDIFPYEHSRVILKKglqsskgiKHSHSTSDggildnYINANYLSlprfsveq
.. .... . .  .... . | .|  . |..   ...  |   |||| || ....|||.|.|        ...   ||      |||| .|.        
aavkkkkkltgyalefqrlnsvss..eieeeekevarkpenkkkNRyadiialdssRvvLek........edadeesd......YiNAsflh........

nssfqtT----TtttrrvRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQE---GNYNGIHVKLLEKK
      .    .       .||||||...||.||.  . .. .  .  |||  | .  |. .|| .    .|. |.|.||.|.
......aykgrn......afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllske
subfamily_Ptp69D_pd Subfamily Ptp69D 488-880 1e-24 82.2 In-house 14-287 (307) alignment 
Range on Protein: 488-880
Range on HMM: 14-287/307.0
KRSHSQPIFTQYSKYKSMLSLESDSDSEsddviISSGVELGAKNRYKDIFPYEHSRVILKKglqsskgIKhSHSTSDggildnYINANYLSlprfsveqn
| .. .. |     |... . |.| ...     .|   |   ||||.|| .... ||.|||       |.  . .||      ||||...          
ksrkrdtdfglakeyekLeareidkstk.....vsekkenalknRyedikafDktRvkLkk.......in.gkedsd......Yinasfik.........

sSFQTtttttrRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQ---EGNYNGIHVKLLEKKILKMPSTTSMRKNTMGTQNSSL
 ...       . ..|| |.|. .|..||.  | .  | |.  |.|  |   .|| .||    | .|. | ||| ...  .     ..   ... . . .
.gyke......kkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgev

ysagvqgnssnystdndndndnnnnnnnnsniavtaaacdddddddddailirkilltyhdqEKPYELLQIQVKNWPDLGTLLNPISILQAINVknhiid
                                                              |.  ...| . ..|.|      . ..|. |.       
..............................................................edsrkvvqyhytgWkDskvPevargllklieq......

tlfARNYYQNDQLPtILVHCSAGCGRTGTLCTIDSILSNFEMfemlqKEFVKlkypakLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFYFR
   .|. |.... | |.|||||| ||.|.. ..||.| . .       . |.      .|.    |.   |.||  .||...|..|.|  || |  
...vrelyklnrsP.ivvhCsaGvgrsgifvaldsllqqlka.....edkvd......ife....tvkdLrsqRnllvqsleqYvflyralldyss
DSPc_SM00195 497-879 3.2e-75 248.2 In-house 4-262 (263) alignment 
Range on Protein: 497-879
Range on HMM: 4-262/263.0
TQYSKYKSMLSLEsdsdsESDDV-----IissgvelgAKNRYKDIFPYEHSRVILKKGLQSskgikhshstsdggILDNYINANYLSLPrfsveqnssfq
....|.... | .     |....              .|||||.|.||.|.||.|||  ..                ..||||||....           
eefekleestspk.....etteaekkknk........sknRyknilpydhtrVklkkeekk..............egsdYINAnyikga...........

tttttTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEG-----NYNGIHVKLLEKKILKmpsttsmrkntmgtqnsslys
     ... .|||||.|.||||.||........|.....||...||| |||.|||.|      ... |.||| |... |                     
.....nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk.....................

agvqgnssnystdndndndnnnnnnnnsniavtaaacddddddddDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTL
                                             | | .|.. ||....|..... |.|.||||| |.  .. |.|. ... ..  .| 
.............................................deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts

farnyyqndqLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMlqkefvklkypaklfDPISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
           ..|.||||||.|||||..|||.|||..|. ..               . |..... .||||..|||. .|..|||...|.|.
..........sgpivVhCsaGvgRtgtfvtidiilskleeekk...............vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 497-879 3.2e-75 248.2 In-house 4-262 (263) alignment 
Range on Protein: 497-879
Range on HMM: 4-262/263.0
TQYSKYKSMLSLEsdsdsESDDV-----IissgvelgAKNRYKDIFPYEHSRVILKKGLQSskgikhshstsdggILDNYINANYLSLPrfsveqnssfq
....|.... | .     |....              .|||||.|.||.|.||.|||  ..                ..||||||....           
eefekleestspk.....etteaekkknk........sknRyknilpydhtrVklkkeekk..............egsdYINAnyikga...........

tttttTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEG-----NYNGIHVKLLEKKILKmpsttsmrkntmgtqnsslys
     ... .|||||.|.||||.||........|.....||...||| |||.|||.|      ... |.||| |... |                     
.....nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk.....................

agvqgnssnystdndndndnnnnnnnnsniavtaaacddddddddDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTL
                                             | | .|.. ||....|..... |.|.||||| |.  .. |.|. ... ..  .| 
.............................................deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts

farnyyqndqLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMlqkefvklkypaklfDPISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
           ..|.||||||.|||||..|||.|||..|. ..               . |..... .||||..|||. .|..|||...|.|.
..........sgpivVhCsaGvgRtgtfvtidiilskleeekk...............vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 500-662 5.8e-14 46.8 In-house 25-156 (288) alignment 
Range on Protein: 500-662
Range on HMM: 25-156/288.0
SKYKSMLSLESDsdsesDDVIISSGVELGAKNRYKDIFPYEHSRVILKKGlqsskgikHSHSTSDggildnYINANYLSlprfsveqnssfqtttTTTRR
..|.|. .||..     ..| ...  .   ||||..| ||.. || |||.        .  ...|      ||||.|.                  . ..
eeynsLaalekt.....ksvtagrlavnakknRyrnilpyDekrvklkkl........eeeagaD......Yinasyid................gekkk

VRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGN----YNGIHVKLLEKK
 .|||||.|...||.||.  . .| .  .. ||.  |.| .|| .|| ...    |  . |.|.|.|
kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk
0047943 (Phosphotyrosine protein) phosphatases II 501-879 1.8e-55 183.7 In-house 20-272 (273) alignment 
Range on Protein: 501-879
Range on HMM: 20-272/273.0
KYKSMLSlesdsdseSDDVIISSGVELGAKNRYKDIFPYEHSRVILkkglqsskgikhshstS----DggildnYINANYLSLPrfsveqnssfqttttt
...|.          . .  ... .| . |||||||.||.||||.|                .    |      ||||.|....                
lllslkp........lltysvallpenkdknrykdilpydhsrvkl................gdggsd......yinAsyvdgy................

TRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQ------EGNYNGIHVKLLEKKilkmpsttsmrkntmgtqnsslysagvq
 .  ..||||.|.|.||.||. .. ...|... .||...|.| |||..||       . .|. ..|.||. .                            
nlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllsee............................

gnssnystdndndndnnnnnnnnsniavtaaacddddddDDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARn
                                        .| . .|.. ||... .....  ......||| |.  .. |.|. |.. .... .|.   
.......................................tkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.

yyqndqlPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
       ....||||||.|||||....| .|. .|.  ..                .  ... .|.||  |||. .|..|.|..||.|.
.......gpvvVHCsaGvgRtgtfialdllldqlekeggvd...............vleavkllrsqRpgmvqtpeqyrflyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 504-879 3.8e-57 189.3 In-house 31-286 (288) alignment 
Range on Protein: 504-879
Range on HMM: 31-286/288.0
SMLSLESDsdsesDDVIISSGVELGAKNRYKDIFPYEHSRVILKkglqsskgikhshsTSDGGILDNYINANYLSLPRFSveqnssfqttttttrrVRYI
 .|||  |      .. ... .|   ||||.||.||.||||.|.              . ||   ..||||.|.......                 ..|
ellsllpd.....ltlsaallpenleknRysdilpydhsRVkLs..............vldgvegsdYinAsyidgynlk................rkfI

ATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQ---EGNYNGIHVKLLEKkilkmpsttsmrkntmgtqnsslysagvqgnssnystdn
|||.|.|.||.||.  . ...|... .||. .|.| |||..||      .|. |.|.||.                                        
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllse.......................................

dndndnnnnnnnnsniavtaaacdddddDDDDAILIRKILLTYH----DQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDtlfarnyyqnDQ
                            . .| . .|.. .|..     ......  .....|||| |.  .| ..|. ..  .. .           ..
............................evlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..........sg

LPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
 ....||||||.|||||....| .|. .|  ...                .  ... .|.||  |||. .|..|.|..||.|.
ggpvvVHCsaGvgRtgtfialdllleqlekeggvd...............vleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN23_pd Subfamily PTPN23 507-650 4.1e-15 50.3 In-house 23-133 (288) alignment 
Range on Protein: 507-650
Range on HMM: 23-133/288.0
SLESDSDSESDDVIISSGVELGAKNRYKDIFPYEHSRVILKkglqsskgikhshstsdgGILDNYINANYLSlprfsveqnssfqTttTTTRRVRYIATQ
 ||.. | |. .  |.       |||..||.||.|.|| |.                  |  |.|||| ..                  ..    .||||
eleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr..................gskDDYinAsfvk.............d..lspgcPdfiatq

APMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGN
||..||. ||.  . .. ....  |..  | | .|. ||| | .
aPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk
subfamily_PTPRG_pd Subfamily PTPRG 510-877 7.8e-30 98.6 In-house 30-285 (563) alignment 
Range on Protein: 510-877
Range on HMM: 30-285/563.0
SDSDSESDDVIISSGVELGAKNRYKDIFPYEHSRVILkkglQSSKGIKHSHstsDggildnYINANYLSlprfsveqnsSFQttttttRRVRYIATQAPM
| . |.. |.  |.  |   |||| .| .|..||| |    ..  |.|...   |      ||||||.            .|      .   .|||| |.
setiskdldaehsqkpenkrKnRylnivaydrsRvkl....splpgkkkkl...D......YinAnyid..........Gyq......kskafiatqgpl

PSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEG---NYNGIHVKLLEKKILKMPSTTsmrkntmgtqnsslysagvqgnssnystdndndndn
..|..||.  | .. | ..  .||  |.| .|| .|| .    .|. ..|.| |...| ....                                     
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvr....................................

nnnnnnnsniavtaaacdddddddddAILIRKILLTYHDQ-EKPYELLQIQVKNWPDLGTLLNPISILQAINVKnhiidtlfarNYYQNDQLPTILVHCS
                           . |... |  ..| ..  .  | .  .||| |.   ..  |. .. .          .. ....   |.||||
..........................tlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..........saankaeaGPivvHcs

AGCGRTGTLCTIDSILSnfemfEMLQKEFVKlkypakLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLF
|| |||||.. .|..|      .. |.. |       .|.    ..  .| ||  .||...|.||..| || 
aGvgrtGtyivldtllk.....qiqqenavn......vfg....flkhiraqRnflvqteEqYiflhdalle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 510-646 7.7e-08 26.7 In-house 26-128 (288) alignment 
Range on Protein: 510-646
Range on HMM: 26-128/288.0
SDSDSESDDVIISSGVELGAKNRYKDIFPYEHSRVILKkglqsskgikhshstsdgGILDNYINANYLSlprfsveqnssfqtttTTTRRVRYIATQAPM
 ||  |.   ||.| ..  ...||....  . .|| |.                     | ||.|| .|                ..  . | | .|||.
rdspneasidiidsfianptrdryenlprcditrvkls..................ddpdfyiaanvvs................sakykrrlicaqaPl

PSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYW
 .|.  ..  .|...|  .. |..  | | ||   |.
ngtieelWkmllesdveyivmlcellekGkeksaeyf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 512-665 9.6e-15 49.3 In-house 32-154 (287) alignment 
Range on Protein: 512-665
Range on HMM: 32-154/287.0
SDSESDDVIISSGVELGAKNRYKDIFPYEHSRVILKkglqsskgikhshstsdgGILDNYINANYLslprfsveqNsSFQttttttRRVRYIATQAPMPS
 . . |.| ..   .   |||...| ...  ||.||                  |  ..|||| ..         . ...       . ..|....|| .
vtqredevthniasqnkdknRltqilvpdnyrvllk..................gehpdyinavfi.........d.gyk......ekkafiiaesPmfn

TVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGN---YNGIHVKLLEKKILK
|. .|.  | .. |. .. |... ||  |.||.|| |..   .   ...||.... .
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevna
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 513-649 1e-15 52.3 In-house 22-129 (287) alignment 
Range on Protein: 513-649
Range on HMM: 22-129/287.0
DSESDDVIISSGVEL--GAKNRYKDIFPYEHSRVILkkglqsskgikhSHSTSDGGildNYINANYLSlprfsveqnsSFqtttttTRRVRYIATQAPMP
||||  ..  .  ||    |||| |..|....||.|            |. .  |    .||||||..          |.      |.  ..||.|.|..
dsesstatfkaaeelaavkknryadvlPiddtrvll............saegelGs...dyinanyva..........sy......tddeafiaaqgPia

STVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEG
.|| ||.. .|.. .  |. .| . |..  |||.|| | 
atvrdfwravletrsasvitmtreveearlkcykywPer
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 514-879 1.1e-25 85.2 In-house 33-283 (290) alignment 
Range on Protein: 514-879
Range on HMM: 33-283/290.0
SESDDVIISSGVELGAKNRYKDIFPYEHSRVILKKglqsskgikhshSTSDGGILDNYINANYLSlprfsveqnsSFQttttttRRVRYIATQAPMPSTV
...  | .  . .   .||...| .|.  |..|..             ...    ..|||| |.            ..       . .|||||.|...|.
esehtvtvgltssnkllnRfanivvyddnritLrp............isghkDCtneyinAcyik..........gyk......ekkqyiatqgpvsntl

HDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEG---NYNGIHVKLlekkilkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndnnnnn
 ||.  | .. |. .. |||  |.| .||. || .    .|. ...||                                                    
vdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikl....................................................

nnnsniavtaaacddDDDDDDDAILIRKILLTYHDQ-EKPYELLQIQVKNWPDLGTLLNPISILQAINVKnhiIdtlfaRNYYQNDQlPTILVHCSAGCG
                ..   . . .||. .. ... ... .. | |..||.. | . || .||..|.     .     .. ... .   |.||||.. |
...............lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieem...y.....ktqrkrgn.tsivvHCSdtvg

RTGTLCTIDSILSNFEMfemlqKEFVklkypaKLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFYF
|....|...  .   ..     .  .       .|.     ..  | |.  .||  .|. .|.. .| |.
rsavfcaaattinkckt.....egvi......dvfq....vlksqRiqkpgsvqtvqqyqgifqivltyl
0050432 (Phosphotyrosine protein) phosphatases II 515-883 3e-60 199.5 In-house 56-303 (308) alignment 
Range on Protein: 515-883
Range on HMM: 56-303/308.0
ESDDVIISSGVELGAKNRYKDIFPYEHSRVILkkglqS-SkgikhshstsdggilDNYINANYLSLPRfsveqnssfqttttTTRRVRYIATQAPMPSTV
.. .  ... .| . |||||||.||.||||.|     . .               ..||||.| ...               . .. ..||||.|.|.||
plleysvallpenkdkNrykdilpydhsRVkl.....deg...............sdYInAsyvdgys..............sklprkfIatqgPlpntv

HDFYTCILNNGVPLVLSLTNDFENGIEKCYRYW------QEGNYNGIHVKLLEKkilkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndnn
.||.  . ...|...  ||. .|||.|||..||      .  .|....|.||.                                               
edFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllse..............................................

nnnnnnsniavtaaacdddddDDDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIdtlfaRNyyqndqlPTILVHCSAG
                     . .| . .|.. ||... ..  .. ... .|||| |.  .| ..|. ..  .. .     ..       ..|.||||||
.....................evlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pg.......gpivVHCsaG

CGRTGTLCTIDSILSNFEMFEMLQkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRL
.|||||....| .|. .|.  ..                .  ... .|.||  |||. .|..|.|..||.|..|.|
vGRtGtfialdllleqlekeggvd...............vfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 516-664 3.5e-14 47.6 In-house 37-158 (319) alignment 
Range on Protein: 516-664
Range on HMM: 37-158/319.0
SDDVIISSGVELGAKNRYKDIFPYEHSRVILKKglqsSKGIKHShstsdggildNYINANYLslprfsveqnSSFQttttttRRVRYIATQAPMPSTVHD
.|..  .|  |   ||||..| .|...||.|..     .|.. |          .||||...           ..|      .|...||||||.  |..|
ndtfdsaskeenkkknryqnilaydrtrvvlse....ldgvegs..........dyinasfi..........dgyq......erekfiatqaPlentied

FYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGN---YNGIHVKLLEKKIL
|.  . ....  |. ||.. |..  |. .||.| |   |  . |.|.|.. |
fWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeel
0043336 (Phosphotyrosine protein) phosphatases II 517-663 7.6e-27 89.9 In-house 35-153 (278) alignment 
Range on Protein: 517-663
Range on HMM: 35-153/278.0
DDVIISSGVELGAKNRYKDIFPYEHSRVILKKglqsskgikhshstSDGGILDNYINANYLSlprfsveqnssfqtttTTTRRVRYIATQAPMPSTVHDF
|.  |.  .| . |||||||.||.||||.|.                .|   ..||||.|..                .  .  ..||||.|.|.||.||
dtysiallpenkdknrykdilpydhsrvklsl..............lggdldsdYinAsyvd................gynvprkfiatqgPlpetvedF

YTCILNNGVPLVLSLTNDFENGIEKCYRYWQeG---NYNGIHVKLLEKKI
.  . ..||. ...||...|.| .||..||  |   .|....|.||. . 
wrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 517-647 5.8e-11 36.8 In-house 23-122 (283) alignment 
Range on Protein: 517-647
Range on HMM: 23-122/283.0
DDVIISSGVELGAKNRYKDIFPYEHSRVILKKGLQsskgikhshstsdggildNYINANYLSLprfsveqnssfqtTTTTTRRVRYIATQAPMPSTVHDF
 |. |.|  |   |||...| |..  || ||   .                  .|||| .. .             .    .  .||..|.|.  || ||
ldadiasadenkrknrnqeivpadqwrvelksesr..................dyinavfipv.............sksykqdkkyiiaqsPldrtvvdf

YTCILNNGVPLVLSLTNDFENGIEKCYRYWQ
.  . .. .  .. ||.  |.  .|| .|| 
WkmvfdekitaivmltklqedlrikCsqyWP
0036941 (Phosphotyrosine protein) phosphatases II 518-883 1.1e-56 187.7 In-house 30-281 (297) alignment 
Range on Protein: 518-883
Range on HMM: 30-281/297.0
DVIISSGVELGAKNRYKDIFPYEHSRVILkkglQ--SskgikhshstsdggilDNYINANYLSlprfsveqnssfqtttTTTRRVRYIATQAPMPSTVHD
.  ... .|   |||||||.||.|.||.|    .  .                ..||||.|..                .  .  ..||||.|.|.||.|
slsvallpenleknRykdilpydhtRVkl....ddeg................sdYinAsyvd................gydlkrkfIatqgPlpntved

FYTCILNNGVPLVLSLTNDFENGIEKCYRYW-----QEGNYNGIHVKLLEKKIlkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndnnnnn
|. ......|. ...||...|.| |||..||     .. .|....|.||. ..                                               
FWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvev...............................................

nnnsniavtaaacdddddDDDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIdtlfaRNYYQNdqlPTILVHCSAGCGR
                  ...| . .|.. .|... ...... ......||| |.  .| |.|. |.  ....     ......   . .|||||||.||
..................vllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl.....kllpsg...gpvlVHCsaGvgR

TGTLCTIDSILSNFE---MFEMLQkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRL
.||....| .|. .|   . . .                |  ... .|.||  .||. .|..|.|..||.... .|
sgtfiaadlmlqqledklkeggvd...............ileavkklReqRpgavqtleqyrflyeallellkkkl
0046845 (Phosphotyrosine protein) phosphatases II 518-883 1.5e-56 187.2 In-house 19-278 (284) alignment 
Range on Protein: 518-883
Range on HMM: 19-278/284.0
DVIISSGVELGAKNRYKDIFPYEHSRVILKkglqsskGI-------KhshstsdggildnYINANYLSLPRFSVEqnssfqtttttTRRVRYIATQAPMP
.. ..  .|   |||||||.||.||||.||        .                     ||||.|.. . ...             .. ..||||.|.|
slsvallpenlsknRykdilpydhsRVklk.......sldgdledsd.............YinAsyvdgydldlt...........yikkkfIatqgPlp

STVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEG----NYNGIHVKLLEKkilkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndn
.||.||. ......|... .||. .||| |||..|| .     .|....|.||..                                             
ntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllse.............................................

nnnnnnnsniavtaaacdddddDDDDAILIRKILLTYHD-QEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTlfarnyyqNDQLPTILVHCS
                      . .| . .|.. ||...  ...... ......||| |.  .| ..|. ..  .....         ... ..|.||||
......................evkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen........lpgggpivVHCs

AGCGRTGTLCTIDSILSNFEMFE---MLQkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRL
||.|||||....| .|. .|  .   ..                .  ... .|.||  |||.  |..|.|..||.|..|.|
aGvgRtGtfialdllleqlekeglllgvd...............vleavkrlreqRpgmvqtleqyrfvyealleylklkl
0040438 (Phosphotyrosine protein) phosphatases II 518-663 2.3e-29 98.1 In-house 34-152 (317) alignment 
Range on Protein: 518-663
Range on HMM: 34-152/317.0
DVIISSGVELGAKNRYKDIFPYEHSRVILKKglqsskgikhshstSDGGILDNYINANYLSlprfsveqnssfqtttTTTRRVRYIATQAPMPSTVHDFY
.  ... .| . ||||.||.||.||||.|.                .|   ..||||.| .                .  .. ..||||.|.|.||.||.
tysvaelpenkdknrypdilpydhsRVkLsp..............lggdldsdYInAsyvd................gpnlkrkfIatqgPlpntvedFw

TCILNNGVPLVLSLTNDFENGIEKCYRYW---QEGNYNGIHVKLLEKKI
 .. ..|| ....||. .|.| |||..||   .. .|....|.||. . 
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee
0045098 (Phosphotyrosine protein) phosphatases II 519-881 1e-51 171.3 In-house 25-274 (278) alignment 
Range on Protein: 519-881
Range on HMM: 25-274/278.0
VIISSGVELGAKNRYKDIFPYEHSRVIlkkglqsskgikhshstsdggildNYINANYLslprfsveQ---NssfqttttttrrvRYIATQAPMPSTVHD
.  .  .. ..|||||||.||.||||.                        .||||.|.        .   .             ..||||.|.||||.|
itpalylgnldknRykdilpydhsrVk........................dYINAsyi........dgypk.............kfIatqgPlpstvad

FYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGN---YNGIHVKLLEKkilkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndnnnnnnn
|. .. ..|.. ...||. .|.| |||..|| ||.   |....|.||.                                                    
fwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllse...................................................

nsniavtaaacdddddDDDDAILIRKILLTYH----DQEKPYELLQIQVKNWPDLGTLLNP--ISILQAINVKNHIIDTLFARNYY---QNDQLPTILVH
                .  | . .|..|.|.        ..... ... ..||| |.  .|   |.|....  .. ...|. . ..   ..|.  ..|||
................evlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CSAGCGRTGTLCTIDSILSNF----EmfemlqkefvklkypaklfdpISWTINIFRKQRIS-MVQNINQFIFIYDCLLFYFRL
||||.||||||. .. .|...                          .  ... .|.||   .||| .|..|.|..|| ... 
CsaGvgRtGtlvaaylmlelleggvd.....................lleavkelrsqRpglavqnleqyrflyefllelllr
0049772 (Phosphotyrosine protein) phosphatases II 519-880 8.4e-23 77.0 In-house 38-281 (314) alignment 
Range on Protein: 519-880
Range on HMM: 38-281/314.0
VIISSGVELGAKNRYKDIFPYEhSRVILkKGLQSskgikhshstsDGgilDNYINANYLSLPrfsveqnssfqttttttrrVRYIATQAPMPSTVHDF--
. ... ..   ||||.||.|.. .|||| .||             .|    .||||.|.. .                    ..||||.|.. ||.||  
ilvadlflnrdknryldilpad.nrvil.pglpv...........sg...sdyinasyvdgf...................lkfIatqgpleitvvdfre

--------YTCIL--NNGVPLVLS---------------------LTNDFENGiekcyRYWQEGNYNGIHvkllekkilkmpsttsmrkntmgtqnssly
        .. .|   . |  .                       |..  .||      .. . ..  ..                              
epvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk..............................

sagvqgnssnystdndndndnnnnnnnnsniavtaaacdddddddddailirkilL-------TyhdqekpyEL--LQIQVKNWPDlGTLLNPISILQAI
                                                                        |   ..    ..|| |.   .  .....
.......................................................eelydpelf........erlgikylripvpD.gsaplledfdefl

NVKNHIidtlfarnyyqnDQLPTILVHCSAGCGRTGTLCTIDSILSNFEmfemlqkefvklkypaklFdPISWTINIFRKQRI-----SMVQNINQFIFI
.. .              |.   .||||.||.|||||..... ... .                   . ..  ... .|..|      ..... .|..||
efieea............dkggpvlvHCkaGkgRtgtfvvaaylmkllg..................v.sleealedvrlkRpinpnpgfieqleqyefi

YDCLLFYFR
...|| |..
lealleylk
subfamily_PTPRB_pd Subfamily PTPRB 521-880 2.2e-35 117.1 In-house 45-286 (293) alignment 
Range on Protein: 521-880
Range on HMM: 45-286/293.0
ISSGVELGAKNRYKDIFPYEHSRVILKKglqsskgiKHSHSTSDggildnYINANYLSlprfsveqnsS--FqttttttrRVRYIATQAPMPSTVHDFYT
...  .  |||||..| ||.|||| |..         ...|.||      ||||||..                      .  .|||| |.|.||.||. 
aaelavnraknrytnilpydhsrvkLaa........lkdesgsD......Yinanyip..........gyns........prefiatqGPlpetvddfWr

CILNNGVPLVLSLTNDFENGIEKCYRYWQEGnyngihvkllekkilkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndnnNNNNNNSNIAV
 .... .  .. ||. .|.| .|| .|| .                                                           ... .  .| |
mvwekkssiivmltqlvekgkvkCeeYWPad..........................................................eepvlyGdikv

TAAAcddddDDDDDAILIRKILLTYHDQEkpYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTlfarnyyQNDQLPtILVHCSAGCGRTGTLCTID
|  |     ... .   ||..... ...|   .. | . . ||| |   .. ..|. ..  .. |..       .... | |.|||||| |||||. ..|
tlva.....eeeledwvirelkiekekee..rkvrqyhftsWpdhgvPektktlldfvrtvreaiek.......taskrP.ivvhCsaGvGRtGtfiald

SILSNFEMfemlqkefvklkypAKLFDPISwTINIFRKQRISMVQNINQFIFIYDCLLFYFR
 .|.. |                 . | .. ..  .|..| ..||. .|.|||..|.| ..|
rllqaiee..............edyvdifg.ivaelReeRnllvqtekqYifihqcvldllr
0040439 (Phosphotyrosine protein) phosphatases II 521-661 3.8e-26 87.6 In-house 5-118 (249) alignment 
Range on Protein: 521-661
Range on HMM: 5-118/249.0
ISSGVELGAKNRYKDIFPYEHSRVILKKglqsskgikhshstSDGGILDNYINANYLSLPRFSVeqnssfqttttttrrvRYIATQAPMPSTVHDFYTCI
... .| . ||||.||.||.||||.|.                .|. |..||||.|.......                 |.||||.|.|.||.||.  .
vallpenkdknrypdilpydhsrvklsi..............lpglflsdyinAsyidgyyikr................rfiatqgPlpetvedfwrml

LNNGVPLVLSLTNDFENGIEKCYRYWQEG---NYNGIHVKLLEK
 ..|.  ...||...|.| |||..|| .|   .|....|.||. 
welgitvivmLtslvelgrekcaqywplggsleygdftvtllsv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 521-881 9e-18 59.0 In-house 34-295 (301) alignment 
Range on Protein: 521-881
Range on HMM: 34-295/301.0
ISSGVELGAKNRYKDIFPYEHSRVILKKGLQSSKgikhSHStsdggildNYINANYLSlprfsveqnssfqtttTTTRRVRYIATQAPMPSTVHDFYTCI
..   |  | ||.|.| .|.. |.|||.  . ..    ..         .||||.|..                 .... ..||.|.|| .|. ||.  |
vglseenkalnrfknitvyddnriilkpkpnldl....cqr........eyinasyid................gysekkkfiaaqgpmkktlvdfWrli

LNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIHVKLLEKKILK---MPSTTsMRKNTMGTQNSSLysagvqgnssnystdndndndnnnnnnnnsnia
... .  .. .||  |.  .||..||.... .  ..  .. .. .   .|. . .|. ..  |..|                                  
wqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfv.irqlnvkiqdgsn.................................

vtaaacddddddddDAILIRKILLTYHDqeKPYELLQIQVKNWPDLGTLLNPISILQAINvknhiidTLFARNyyQNDQLPTILVHCSAGCGRTGTLCTI
              .. ..||.  . .   .....||.|| .||. | . .|  .||.|.           |.  |      ..||||.. .|.|. |..
..............ngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqvid.......dvihrq..qkigggpvvVHCSdtVsrsGvYcsv

DSILsnfemfEMLQKEFVklkypaklFDPISwTINIFRKQRISMVQNINQFIFIYDCLLFYFRL
.  |      |  . | |         | .   ..  |...  .|. ..|...||| .  |..|
sigl......EQckaegV........Vdvfq.vtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 521-644 2.6e-06 21.6 In-house 27-116 (267) alignment 
Range on Protein: 521-644
Range on HMM: 27-116/267.0
ISSGVELGAKNRYKDIFPYEHSRVILKKGLQSskgikhshstsdggildnYINANYLslprfsvEqnsSFQTTTtttrrvRYIATQAPMPSTVHDFYTCI
 | . .  ..||. |  ||...||||..  .                   |||| |.       |   ...|         .|.|| |.  |. ||.| |
qsiaeknqernrlddnlpyddtrvilrtkeee..................yinasyv.......e...gyktkn......afivtqdplkntitdfltvi

LNNGVPLVLSLTNDFENGIEKCYR
 ...|| .  ||. |.. | . . 
hdqkvpvivlltkvftdnirlfwP
0037934 (Phosphotyrosine protein) phosphatases II 524-879 3e-49 163.1 In-house 7-242 (243) alignment 
Range on Protein: 524-879
Range on HMM: 7-242/243.0
GVELGAKNRYKDIFPYEHSRVILkkglqsskgikhshstsDGgilDNYINANYLSLPRfsveqnssfqttttttrrvRYIATQAPMPSTVHD----FYTC
 .|   ||||.||.||.||||.|                 .|   ..|||||.   ..                   |.||||.|.|.||.|    |.  
lpenlsknrysdilpydhsrvkl.................eg...sdyinanliyvtp...................rliatqgPlpetveddlasfwrm

ILNNGVPLVLSLTNDFENGIEKCYRYW-QEGNYNGIHVKLLEKKilkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndnnnnnnnnsniav
. ..|.  ...||...|.| |||..|| .| .|....|.||. .                                                        
lwelgitvivmltelvElgrekcaqywpgevtygdftvtllsee........................................................

taaacddddddDDDAILIRKILLTYHD-QEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARNYYQNDqlPTILVHCSAGCGRTGTLCTI
             | . .|..||...| .. ...  ...  .||| |.  .| ..|. ..  . .|. |.  ... ..   ..|||||||.||||||...
...........hlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpvlVHCsaGvgRtGtliaa

DSILSNFEMFemlqkefvklkypaklfdpISWTINIFRKQRIS-MVQNINQFIFIYDCLLFYF
. .|.....                    .  ... .|.||   .||. .|..|.|..||...
ylmllllgvd...................leeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 525-651 2.3e-12 41.7 In-house 44-140 (305) alignment 
Range on Protein: 525-651
Range on HMM: 44-140/305.0
VELGAKNRYKDIFPYEHSRVILKKglqssK---GikhshstsdggiLDNYINANYLSlprfsveqnsSFQttttttRRVRYIATQAPMPSTVHDFYTCIL
 .  ||||.|.|......|.||..     |   .              .||||.|.           ...      |. .||..|.|...||.||.  |.
eankaknrlkeitlldddriilte.....kesld............dsdyinasyvd..........gyk......rkkkyivaqgPlkntvadfWrliv

NNGVPLVLSLTNDFENGIEKCYRYWQEGNY
.  |  .. ||.  |.| .||..|| |   
eekvstivmltklveggkdkCrqYWpeskt
subfamily_PTPN6_pd Subfamily PTPN6 526-881 4e-41 136.0 In-house 53-299 (306) alignment 
Range on Protein: 526-881
Range on HMM: 53-299/306.0
ELGAKNRYKDIFPYEHSRVILKkglqsskgiKHSHSTsdggilDNYINANYLSlprfsV--EQNSsfqttttttrrVRYIATQAPMPSTVHDFYTCILNN
|   ||||| |.|..|.|||||         ..| .       ..||||||..        ....            .|||||  ...|| ||.  ....
enkeknryknilPfDhtrvilk.........epsvpg......sdyinanyik.....kevkgsd...........ksyiatqgclettvsdFWrmvwqe

GVPLVLSLTNDFENGIEKCYRYWQEG----NYNGIHVKLLEKKilkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndnnnnnnnnsniavt
   ... .|.. | | |||.||| .     .|  |.|. ...|                                                         
nsrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvsek.........................................................

aaacddddddDDDAILIRKILLT-YHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARnyyqndQLPTILVHCSAGCGRTGTLCTID
          . ..  .|.....  .....  |. | . |.||| |.  .|  .|. ..  |.  ..| ..      .   |.|||||| |||||.  ||
..........sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea......eagpivvhCsaGiGRtGtfiviD

SILSNFEMfemlqkEfvKLKYPAKlfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRL
 .|.. |       .  .|...      |  .... |.||  .||  .|. |.|  . .| . 
illkliek......k..gldadid....iqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_CG7180_pd Subfamily CG7180 526-878 5.9e-16 53.0 In-house 41-289 (296) alignment 
Range on Protein: 526-878
Range on HMM: 41-289/296.0
ELGAKNRYKDIFPYEHSRVILKKglqsskgikhshstSDGGILDNYINANYLslprfsveqNsSFqtttttTRRVRYIATQAPMPSTVHDFYTCILNNGV
|   |||. .. ||.. ||.|.|               ||   ..|||| |          . ||      ..   || |.||. .||..|.. . ....
enreknrdvkvvPyDynRvvLek..............ldGeeksdYinavyv.........d.sf......lkkkeyivteapkketvdefWrlvydeei

PLVLSLTNDFENGIeKCYRYWQEG---NYNGIHVKLLEKKILKMPSTTSMRKNTMgtqnsslysagvqgnssnystdndndndnnnnnnnnsniavtaaa
  |  ||. |.    ..  ||..    .|  | |...|.| .    .  .. . .                                             
savvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkk.............................................

cdddddddddailirkiLLTYHDQEKP-----YELLQIQVKNWPDLGTLlnPISILQAINVKNHIiDTLFARNyYQNDQLPTILVHCSAGCGRTGTLCTI
                 ...  .|||.       ....|.. |.    .  |.|    |.. . .  ..  ..  ....   ..|..| | .|.|  ..|
.................ivalteqekqvkaetRivklfqlteWeledkv..Plstnalielrrrv.rlwrekv.dedpeegPvvvvssdGasRsGvylai

DSILSNFEmfemlQKEFVklkypaKLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFY
|  |   |     ..| |       .|.     .  .|..|  .|.|.... .||| || .
danlelve.....keeev......dvFe....avktlrrsRpqLvenveeYkyiYdvllea
subfamily_PTPRN_pd Subfamily PTPRN 526-652 4.8e-13 43.5 In-house 55-152 (297) alignment 
Range on Protein: 526-652
Range on HMM: 55-152/297.0
ELGAKNRYKDIFPYEHSRVILKKglqsskgiKHSHSTsdggilDNYINANYLslprfsveqnssfqtTTTTTRRVRYIATQAPMPSTVHDFYTCILNNGV
.   |||.|...||.|||| ||.        . |...      ..||||  .               . .  |.  |||||.|..||| ||.  . ..||
knvkknrskavlpydhsrvklke........easaek......sdyinasai...............ldhdprapayiatqgplastvadfwqmvweqGv

PLVLSLTNDFENGIEKCYRYWQEGNYN
 ....||.  |.|...|.||| .   .
vvivnltrleeegvkqckrywpdeGse
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 527-658 7.2e-18 59.5 In-house 20-120 (270) alignment 
Range on Protein: 527-658
Range on HMM: 20-120/270.0
LGAKNRYKDIFPYEHSRVILkkglqsskgikhshSTSDGGILDNYINANYLSlprfsveqnssfqttTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVP
  . |||.|| |  ..||.|              .. .     .||||||.                  . .. .|||...|.|.|...|.  |... |.
gkklnRyadiLPsPatRvrl..............eeleedsataYinAnyvr...............GfdgekkkYiaamgPlpttlksfwrmiweekvt

LVLSLTNDFENGIEKCYRYWQEgnYNGIHVKL
 .. .|.  |.| .|| ||| .   .. .|||
aivmttgleEkgrkkCerYWpa..epkekvkl
subfamily_PTPRA_pd Subfamily PTPRA 527-662 1.5e-10 35.5 In-house 58-166 (330) alignment 
Range on Protein: 527-662
Range on HMM: 58-166/330.0
LGAKNRYKDIFPYEHSRVILKKglqsSKGIKHShstsDggildnYINANYLSlprfsveqnsSFQttttttRRVRYIATQAPMPSTVHDFYTCILNNGVP
   |||. .|.||..||||| .     .|...|    |      |||| ..            ..      .. ..||.| |   ||.||.  | .    
nkeknrvvnilPydfsrvilsv....keGvees....d......yinasfid..........Gyk......ekdkfiaaqGPkeetvedfwrmiweqksa

LVLSLTNDFENGIEKCYRYWQE-G--NYNGIHVKLLEKK
 .. ||.  |   |||..|| . |   |  |.|.. ...
tivmltelkerkeekcaqywPdeGlvtyGnirvevedet
0042113 (Phosphotyrosine protein) phosphatases II 528-879 2.3e-46 153.5 In-house 10-243 (245) alignment 
Range on Protein: 528-879
Range on HMM: 10-243/245.0
GAKNRYKDIFPYEHSRVILKKglqsskgikhshstSDGGILDNYINANYLslprfsveqnssfqttTTT--TRRvrYIATQAPMPSTVHDFYTCILNNGV
. ||||.||.||.|.||.|.                .|   ..||||.|                 ..   |..  .||||.|.|.||.||.  . ..|.
kdknrysdilpydhtrvklsp..............dggdldsdyinasyv................dgyritpk..fiatqgPlpetvedfwrmlwelgi

PLVLSLTNDFENGIEKCYRYWQEG---NYNGIHVKLLEKKilkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndnnnnnnnnsniavtaaa
  ...||...|.| .||..|| .|   .|....|.||. .                                                            
ttivmLteeeelgrvkcaqywplgesltygdftvtllsee............................................................

cddddddDDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTlfarnyyqnDQLPTILVHCSAGCGRTGTLCTIDSILS
        .| . .|.. .|..   .. | ....  .||| |.  .. ..|....  ....           |.  ..|||||||.|||||..... .|.
.......hlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.........dsngpvlVHCsaGvgRtGtfiaaylmle

NFEMFEMLQkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
 .|    .                .  ..  .|.||  .||. .|..|.|..||...
qlekelgvs...............leeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 528-880 1.1e-32 108.3 In-house 29-269 (274) alignment 
Range on Protein: 528-880
Range on HMM: 29-269/274.0
GAKNRYKDIFPYEHSRVILKKGLQSskgikhshstsdgGILDNYINANYLSLPRfsveQN--SsfqttttttrrvrYIATQAPMPSTVHDFYTCILNNGV
  |||||.|.| |.|||.|..  ..               . .||||||.  ..    ..                |.||| |.|.||.||.  | .. |
qtknryktilPnensrvllesesse.............dedssyinanyikGyd....eeska.............yvatqGPlpntvadfWrmiyqeev

PLVLSLTNDFENGIEKCYRYWQegnyngihvkllekkilkmpsttsmrkntmgtqnsslysagvqgnssnystdndnDNDNNNNNNNNSNIAVTAAACDD
.... ||.  |.  .|| .|.                                                        |. . . ...  .. ..     .
qvivmltklkeaneqkCavyfP.......................................................daedyeiserygdveikvekive

DDDddddaILIRKILLTYHDQekPYELLQIQVKNWPDLGTLLNPISILQAINVKnhiidtlFARNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILSNFE
 .|       .||..| |  .  . ..  .   .|||  .  .. ..|. ..            .  .| .| ...|||||| ||||   .|.  . ...
rnd.....ysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvlev.......eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlr

MfemlqkefvklkypAKLFDPISWTINIfRKQRISMVQNINQFIFIYDCLLFYFR
                .  | .. . |. | .|  |||. .|. .|.  |  | .
e..............eivvdvlkivcnl.rldrGGmvqtseqyelihralclylk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 528-657 2.8e-17 57.8 In-house 42-138 (281) alignment 
Range on Protein: 528-657
Range on HMM: 42-138/281.0
GAKNRYKDIFPYEHSRVILKKGLQSSkgikhshstsdggiLDNYINANYLSlprfsveqnssfqtttTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPL
  ||||..|. |...|| ...  ...                .|||||...                . .   .|||||.|.|.....|.  .... | .
vlknrYsnivaYDatrvkvtpneenk..............ntDYinanfvp................gykgekeyiatqgPvPaslvafWqmvweqkvsa

VLSLTNDFENGIEKCYRYWQEGNYngiHVK
.  .|.. |.|  ||.||| ..|    ..|
ivmvtreieagklkChrYWPddns...elk
subfamily_PTPN13_pd Subfamily PTPN13 528-676 8.1e-15 49.8 In-house 38-154 (273) alignment 
Range on Protein: 528-676
Range on HMM: 38-154/273.0
GAKNRYKDIFPYEHSRVILKKglqsSKGikhshstsdggildnYINANYLSLPrfsVeqnssfqttttTTRRVRYIATQAPMPSTVHDFYTCILNNGVPL
 .||||....||...||.|..    . |               ||||... .|   |              . .|||.| |.| ||.||.  . .  . .
kdknryrnvlPydetrvklgd....egg...............yinaslikvp...v...........gkdeyeyiacqGPlPetvkdfwqmvweqkaev

VLSLTNDFENGIEKCYRYWQEGNYNGIHVKL-LEKKILKMPSTTSMRKNT
.  .|.. |.|  || ||| | . . . |.  || . ||.    ..  ..
iamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvra
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 528-659 6.8e-10 33.6 In-house 49-154 (325) alignment 
Range on Protein: 528-659
Range on HMM: 49-154/325.0
GAKNRYKDIFPYEHSRVILKKglqsskgiKHSHSTSDggildnYINANYLslprfsveqNssfqtttTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPL
 ||||.|.. ....|||.|.         |.  . ||      ||||.||         .       .  ..  ..|.|||...|..|..  .|.   ..
kaknrfknvvaldksrvvlet........kkddpssd......yinasyl.........r.......ddkkkdvflaaqaPltatindlWrlvldWrcsv

VLsLTNDFENGIEKCYRYWQEG-----NYNGIHVKLL
|. ..| ...| ..|  || .      .. |..||| 
vv.vlneldlgkdrcavywpkemgksktfGglevklr
subfamily_ptpA1_pd Subfamily ptpA1 528-648 3.3e-09 31.0 In-house 48-137 (418) alignment 
Range on Protein: 528-648
Range on HMM: 48-137/418.0
GAKNRYKDIFPYEHSRVILKKgLQSSKGikhshstSDggildnYINANYLslprfsveqNSSFQTtttttrrvRYIATQAPMPSTVHDFYTCILNNGVPL
 .|||| .|.| .|.|| ||| .|  .|       ||      ||||||.         . ..          ..|.|| |.| |. ||.  . .| . .
tsknrytnilpvnhtrvqlkk.iqdkeg.......sd......yinanyi.........dgaypk........qfictqgplpntiadfwrmvwenrcri

VLSLTNDFENGIEKCYRYWQE
.. |. . ||   || ||| |
ivmlsresencrikcdrywpe
subfamily_PTPRD_pd Subfamily PTPRD 529-886 1.4e-36 121.3 In-house 50-288 (564) alignment 
Range on Protein: 529-886
Range on HMM: 50-288/564.0
AKNRYKDIFPYEHSRVILKKglqsSKGIKHSHstsdggildnYINANYLSlprfsveqnsSFQTtttttrRVRYIATQAPMPSTVHDFYTCILNNGVPLV
|||||..| .|.||||.|.|     .| . |.          ||||...           ....      |  |||||.|...|..||   . .. .  .
aKNRyanivaYdhsRVvLsk....vegdegsD..........YINAsfid..........gyrk......rkayIAtqgPlaetiedFWRmvweqnssti

LSLTNDFENGIEKCYRYWQEG---NYNGIHVKLLEKKILKmpsTTSMRKNTMgTQ-Nsslysagvqgnssnystdndndndnnnnnnnnsniavtaaacd
  ||.  |.| .|| .|| |    .|....|.| |.. |.   . ..|. .. .. .                                           
VmltkleEkgkvkchkYWPekgtetygeltVtleeeeela...dyeirtfkl.kkkk...........................................

ddddddddailirkilltyhdQEKPYELLQIQVKNWPDLGTLLNPISILQAIN-VKNHIiDtlfarnyyqnDQLPTILVHCSAGCGRTGTLCTIDSILSN
                     ...  |  | .  .||| |   .. |.|. |. |...             ..   |.|||||| ||||| ..||..|  
.....................ssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e..........pdagPivVhCSaGVGRTGtfividamler

femfeMLQKEFVklkypaklfDpISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRLDDI
     . ... |         | |  ...  ||||  |||. .|.|||.. .| .     ...
.....ikeektv.........D.iyqyvkalrkqRnamVqteeQYiFiheailealacgntev
Y_phosphatase Protein-tyrosine phosphatase 529-676 4.8e-26 87.0 Pfam-A 3-122 (235) alignment 
Range on Protein: 529-676
Range on HMM: 3-122/235.0
AKNRYKDIFPYEHSRVILkkglqsskgiKHSHSTSDggildnYINANYLslprfsveqnssfqttTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLV
 ||||||| ||...|| |          |.| ..||      ||||||.                .....  ..||||.|..||..||. ..... | ..
kknRykdilpydktrvkl..........kgsegpsd......YInAnyv................kgykekkkfIatQgPlkstiedFWrmvwqekvkvi

LSLTNDFENGIEKCYRYWQ-----EGNYNGIHVKLLeKKILKMPSTTSMRKNT
  ||.. |.| ||| .||.     . .|. |.|.|  .|. .  . . .|| .
vmltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrkle
Y_phosphatase Protein-tyrosine phosphatase 529-676 4.8e-26 87.0 In-house 3-122 (235) alignment 
Range on Protein: 529-676
Range on HMM: 3-122/235.0
AKNRYKDIFPYEHSRVILkkglqsskgiKHSHSTSDggildnYINANYLslprfsveqnssfqttTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLV
 ||||||| ||...|| |          |.| ..||      ||||||.                .....  ..||||.|..||..||. ..... | ..
kknRykdilpydktrvkl..........kgsegpsd......YInAnyv................kgykekkkfIatQgPlkstiedFWrmvwqekvkvi

LSLTNDFENGIEKCYRYWQ-----EGNYNGIHVKLLeKKILKMPSTTSMRKNT
  ||.. |.| ||| .||.     . .|. |.|.|  .|. .  . . .|| .
vmltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrkle
subfamily_PTPN12_pd Subfamily PTPN12 529-650 9.7e-20 65.6 In-house 42-133 (290) alignment 
Range on Protein: 529-650
Range on HMM: 42-133/290.0
AKNRYKDIFPYEHSRVILKKGLQSSkgikhshstsdggiLDNYINANYLSLPrfsveqnssfqtttttTRRVRYIATQAPMPSTVHDFYTCILNNGVPLV
.|||||||.||..||| |.|  ..                ..|||||..  .                . ...|||.|.|.| |..||.  | .  | .|
kknrykDilPydksrvelskieeee..............gsdYinanfikgv................egkleyiaaqgPLpktlddfWrmiweknveiv

LSLTNDFENGIEKCYRYWQEGN
. . . .|.|  || ||| | .
vmaCrevelgkkkCerYWpeeg
subfamily_PTPN3_pd Subfamily PTPN3 529-650 5.2e-18 59.9 In-house 43-134 (280) alignment 
Range on Protein: 529-650
Range on HMM: 43-134/280.0
AKNRYKDIFPYEHSRVILKKGlqssKgikhshstSDggildnYINANYLSLprfsvEQNSsfqttttTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLV
.||||.|| ||.. ||.||..    .        .|      ||||||...     | .|       |.  .|||||| |...|..||.. . .. . |.
sknryrdilpydatrvklkes....e........td......yinanyvnm.....eips.......tglvnryiatqGPlaktatdfWqmvweqkssli

LSLTNDFENGIEKCYRYWQEGN
. ||.  |.|  ||..|| | .
vmlttlverGrvkChqyWPete
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 529-663 2e-16 54.9 In-house 48-155 (318) alignment 
Range on Protein: 529-663
Range on HMM: 48-155/318.0
AKNRYKDIFPYEHSRVILKKglqsskgiKHSHSTSDggildnYINANYLSlprfsveqnssfqtttTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLV
||||| .| .|.|.|| |..        .... .||      ||||||.                   .|.  |||.|||.| |..||.  . . .  ..
aknryanilaydhtrvkLqm........legeegsD......yinanyid................GyrrkkayiaaqaPlpetieDfWrmvWeqnsavi

LSLTNDFENGIEKCYRYW---QEGNYNGIHVKLLEKKI
. ||.  |.| .|. |||   .  .|. ..|.| |.. 
vmltqeeergkakvhryWPskgsrsygklvvelkeeve
subfamily_PTPRK_pd Subfamily PTPRK 529-663 3.7e-15 50.6 In-house 45-151 (314) alignment 
Range on Protein: 529-663
Range on HMM: 45-151/314.0
AKNRYKDIFPYEHSRVILKkglqsskgikhshsTSDGGILDNYINANYLslprfsveqnssfqttTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLV
.|||..|| .|..|||.|.              | ||    .||||...                 . .|   .|.|| |...||.||.  .....   .
eknrsgdilaydrsrvfli..............tidgdpssdyinaali................dsykrpaafivtqgPlqetvkdfWrlvydencasi

LSLTNDFENGIEKCYRYWQEG--NYNGIHVKLLEKKI
. ||.  |.|  ||..|| |    |. |.|.|.| ..
vmltelvevgrvkClkyWPedtevygdikvelvetel
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 529-876 1.9e-12 41.3 In-house 47-233 (392) alignment 
Range on Protein: 529-876
Range on HMM: 47-233/392.0
AKNRYKDIFPYEHSRVILKKglqsSKGIKHShstsdggildNYINANYLslPrfsveqnsSFQTTTTttrrvrYIATQAPMPSTVHDFYTCILNNGVPLV
 |||||.|.||. .||.|.        | .|          .|.|| |.  |        ||..  .      |||.|.| .....||.  .... |  .
kknryknilpydsarvklev....iddipds..........dylnasyi..p........sfdneka......yiasqgpnaaslddfwrmvfqenvtti

LSLTnDFENGIekcyrywqegnyngihvkllekkilkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndnnnnnnnnsniavtaaacddddd
  .| ....|                                                                                          
amvt.klkegd.........................................................................................

ddddailirkilltyhDQEKPYELLQIQVKNWPDLGTLLNPISILQAINvkNhiIDTLFArnYYQNdqlPtILVHCSAGCGRTGTLCTIDSILSNFEMfe
                  ..     | .. .||| .      |.|. |.  .  . . |    |     | ...||||| |||| . .|||...  .   
................kgddartvaqfhftewPdkdvpkhtssllkfik..e..vkadfG..qyth...p.liihcsagvgrtgvvisidsvvahakk..

mlqkefvklkypAKLFDPISWTINIfRKQRISMVQNINQFIFIYDCLL
            ... | . .  || |..|  |||  .|. ||| ..|
............trmvdvfnfvtni.rrkrpymvqtkeqyafiygavl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 529-649 9.8e-12 39.6 In-house 53-140 (297) alignment 
Range on Protein: 529-649
Range on HMM: 53-140/297.0
AKNRYKDIFPYEHSRVILKkglqsskgIKHSHSTSDggildnYINANYLSlprfsveQ--NssfqttttttrrvRYIATQAPMPSTVHDFYTCILNNGVP
 |.|||.| ||. |||.|.        |  ..  ||      |.|| ..           .             |.|.|| ||..|| ||.. .|.. | 
eksRYkniLPydssRvkLa........ivnddpdsD......yvnasfvk.......gnkh.............rlittqmPmkatvadfWamvldeqvs

LVLSLTNDfENGIEKCYRYWQEG
 .. |..| ... .|| |||.. 
tivmlndd.nerdkkcaryWsdk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 529-652 2e-11 38.3 In-house 35-128 (297) alignment 
Range on Protein: 529-652
Range on HMM: 35-128/297.0
AKNRYKDIFPYEHSRVILKKGLQSSkgikhshstsdggildNYINANYLSLPrfsvEQNSSfqttttttrrVRYIATQAPMPSTVHDFYTCILNNGVPLV
 ||||.||. .. .|| |...   .                .||||.|. .|    ....           ..|| .| |. .||.||.| . ...|  .
rknryrdilatddtrvkllrviter................dyinadyvvfp....deead..........lkyilaqGplsatvddfwtlvaeqdvrvi

LSLTNDFENGIEKCYRYWQEGNYN
  ...  |.| .||. || . . .
vmvaklqedGrdkcapywpsvvqe
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 529-663 2e-11 38.6 In-house 11-117 (250) alignment 
Range on Protein: 529-663
Range on HMM: 11-117/250.0
AKNRYKDIFPYEHSRVILKKglqsskgiKHSHSTSDggildnYINANYLSlprfsveqnsSFQTtttttRrVRYIATQAPMPSTVHDFYTCILNNGVPLV
 |||| || ....|||.|.|        ...   ||      |||| .|           ...      |   .||||.|...|. ||.  .|.. .  .
eknryadiialdssrvvLek........ekgdkesd......yinasflh..........gyde.....r.kafiatqgPlqatiedfWrmvleeksgti

LSLTNDFENGIEkCYRYWQ---EGNYNGIHVKLLEKKI
. |||  |.. . . .||      .| ...|.||.|..
vmLtnLkesekt.yhqywPvekaekyGdvtvsllskee
subfamily_PTPN9_pd Subfamily PTPN9 529-661 2.3e-11 38.3 In-house 44-151 (297) alignment 
Range on Protein: 529-661
Range on HMM: 44-151/297.0
AKNRYKDIFPYEHSRVILKKglqsskgiKHSHSTSDggildnYINANYLSlprfsveqnsSFQttttttRRVRYIATQAPMPSTVHDFYTCILNNGVPLV
 ||||.|.  |...|| |.|        .. ...||      |||||..            ..      ..  .|||| |.. ||.||.  . .. |  .
eknrytdvlcydetrvvlak........vdedeasd......yinanfvd..........Gyk......qkkafiatqGplkktvsdfWrmvWeqevlvi

LSLTNDFENGIEKCYRYWQEGN-----YNGIHVKLLEK
.  |   |.|  || .||....     .  ..|. .| 
vmttrvvergrlkcgqyWpleeessaefgdlsvsnvev
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 529-687 4e-11 37.3 In-house 46-174 (315) alignment 
Range on Protein: 529-687
Range on HMM: 46-174/315.0
AKNRYKDIFPYEHSRVILKKglqsskgIKHS-HstSdggildNYINANYLSlprfsveqnsSFQTTTTttrrvrYIATQAPMPSTVHDFYTCILNNGVPL
 |||||.|.|....||.|.        |  | .  |      .|||| |.           |...  .      |||.|.| ...| ||.  .|.. |  
kknryknilPldsarvklev.......iddsPd..s......dyinasyik..........svdddka......yiasqgPlkasvddfwrmvlqekvtt

VLSLTNDFENGIEKCYRYWQEGNYNGIHVKLLEKKILKMPSTTSMRKNTMGTQNSSLYSA
.  .|.  |.   || .|| . . . ..   .. ..|.. ..| . .  ..|..|  .  
ivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 529-679 1.8e-10 34.5 In-house 45-165 (515) alignment 
Range on Protein: 529-679
Range on HMM: 45-165/515.0
AKNRYKDIFPYEHSRVILKKglqsskgIKHShSTSDggildnYINANYLslPrfsveqnsSFQTTTTttrrvrYIATQAPMPSTVHDFYTCILNNGVPLV
 |||||.|.||. .||.|.        |. .   ||      |.|| |.  |        ||..  .      |||.|.| ...| ||.  .|.. |  .
kknryknilPydsvrvklev.......indn.Phsd......yfnasyi..p........sfdndka......yiasqgPnkasvddfWrlvlqenvtti

LSLTNDFENGIEKCYRYWQEGNYNGIHVKLLEKKILKMPSTTSMRKNTMGT
  .|.  |.   || .|| .   . ..   .. ... . . | . | ..  
amvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 529-649 2.3e-09 31.6 In-house 51-141 (315) alignment 
Range on Protein: 529-649
Range on HMM: 51-141/315.0
AKNRYKDIFPYEHSRVILKkglqsskgIKHSHSTSdggildNYINANYLSlprfsveqnssfqtttTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLV
 |||| .| .|..||| |         .   .. |      .|.|||..                   ... ||||.|.| ...|.||.  . .. .  .
qknryiniiaydksrvqlp........llendphs......dyvnanfid................Gynkkrryiaaqgpnvasvkdfwrlvfeedigki

LSLTNDFENGIEKCYRYWQEG
. |||  |.  .|. .|| . 
vmltnlvegekrkaekywpdk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 529-650 2.9e-09 31.5 In-house 5-95 (237) alignment 
Range on Protein: 529-650
Range on HMM: 5-95/237.0
AKNRYKDIFPYEHSRVILKkGLQSSkgikhshstsdggilDNYINANYLslprfsveqnSSFQTTTTTtrrvrYIATQAPMPSTVHDFYTCILNNGVPLV
.|||| .|  |.||||.|| |  |.                .||||.||           .|. |  .     |||.| |. |. .||.  . ..   ..
iknrygnivaydhsrvvlk.gagsg...............sdyinatyl..........kgfdgtpkk.....yiaaqgplesscddfwqmvwqekcsvi

LSLTNDFENGIEKCYRYWQEGN
. ||   |.  .||..|| . .
vmltgliegnelkchkywpstd
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 529-651 3e-06 21.6 In-house 10-105 (239) alignment 
Range on Protein: 529-651
Range on HMM: 10-105/239.0
AKNRYKDIFPYEHSRVILKKgLqsSkgiKHSHStsdggildNYINANYLSlprfsvEQNSSFQTtttttrrvrYIATQAPMPSTVHDFYTCILNNGVPLV
||||| .|  |.||||.|.| |  |   .  ||        .||||.||       . . | ..         |||||  .  .  ||.  . ..   ..
aknryanivtydhsrvvlek.l..s...ndphs........dyinasylr......dydgspka.........yiatqgcveissgdfwrmmwqerrcvi

LSLTNDFENGIEKCYRYWQEGN--Y
. ||   |   .||..|| .    |
vmltglieghkkkchqywpdstsky
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 529-651 3e-06 21.6 In-house 9-104 (239) alignment 
Range on Protein: 529-651
Range on HMM: 9-104/239.0
AKNRYKDIFPYEHSRVILKKgLqsSkgiKHSHStsdggildNYINANYLSlprfsvEQNSSFQTtttttrrvrYIATQAPMPSTVHDFYTCILNNGVPLV
||||| .|  |.||||.|.| |  |   .  ||        .||||.||       . . | ..         |||||  .  .  ||.  . ..   ..
aknryanivtydhsrvvlek.l..s...ndphs........dyinasylr......dydgspka.........yiatqgcveissgdfwrmmwqerrcvi

LSLTNDFENGIEKCYRYWQEGN--Y
. ||   |   .||..|| .    |
vmltglieghkkkchqywpdstsky
0041856 (Phosphotyrosine protein) phosphatases II 530-882 8.3e-32 105.6 In-house 4-174 (182) alignment 
Range on Protein: 530-882
Range on HMM: 4-174/182.0
KNRYKDIFPYEHSRvilkkglqsskgikhshstsdggiLDNYINANYLSlprfsveqnssfqtttT-----TtrrvrYIATQAPMPSTVHDFYTCILNNG
||||.||.||.|||                          .|||||..                       .     .||||.|..||| ||.. . ..|
knrysdilpydhsr........................dldyInanlyl................gslpatr.....fiatqgpllstvadflrmlkelg

VPLVLSLTndfengiekCYRYWQegnyngihvkllekkilkmpsttsmrkntmgtqnsslysagvqgnssnystdndndndnnnnnnnnsniavtaaacd
. ....||         ...||                                                                              
ittivnlt.........eelywp.............................................................................

ddddddddailirkilltyhdQEKPYELLQIQVKNWPDLGTLLnPISILQAINVKNHiidtlfarnyyqndQLPTILVHCSAGCGRTGTLCTIDSILSNf
                     .. . . .|..  .||| |.   . ..|. |.  ..              .  ..|||||||.||||||. .. .... 
.....................ellerlgiqylylpwpDhgvpd.ldelldfieevle..............eggpvlVHCsaGvgRtgtlvaaylmkkl.

emfemlqkefvklkypaklFDPISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLR
                     ..  ... .|..|  ||.. ||..|....||....|.
...................gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 530-648 1.4e-06 22.8 In-house 64-146 (319) alignment 
Range on Protein: 530-648
Range on HMM: 64-146/319.0
KNRYKDIFPYEHSRVILKKglqsSKGIKHShstsDggildnYINANYLslprfsveqnSSFQttttttRRVRYIATQAPMPSTVHDFYTCILNNGVPLVL
|||. .|.......| |..      |.  |    |      |||| ..          . .|      |. .|||.| |.. |. ||.  | .  .  ..
knriinilafdknvvkler....liGeefs....d......yinasfv..........tGyq......rkdkyiaaqGPldntladfWrmiweyncstiv

SLTndfengIEKCYRYWQE
 ||       .|| .||  
llt......kdkcsqywpl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 530-648 1.5e-06 23.0 In-house 28-110 (284) alignment 
Range on Protein: 530-648
Range on HMM: 28-110/284.0
KNRYKDIFPYEHSRVILKKglqsSKGIKHShstsDggildnYINANYLslprfsveqnSSFQttttttRRVRYIATQAPMPSTVHDFYTCILNNGVPLVL
|||. .|.......| |..      |.  |    |      |||| ..          . .|      |. .||||| |.. |. ||.  | .  .  ..
knrighilafdknvvkler....liGeefs....d......yinasfi..........tGyq......rkdkyiatqGPldntladfWrmiweyncstiv

SLTndfengIEKCYRYWQE
 ||       .|| .||  
llt......kdkcsqywpl
0051429 (Phosphotyrosine protein) phosphatases II 568-881 3.9e-28 94.3 In-house 3-227 (272) alignment 
Range on Protein: 568-881
Range on HMM: 3-227/272.0
LDNYINANYLSLPrfsveqnssfqttTTTTRRVRYIATQAPMPSTVHDFYTCiLNNGVPLVLSLTNDFENGIEKCYRYWQegnyngihvkllekkilkmp
|..||||.... .             . .... |......|.| |..|| .   ..|.  ...|....| | .||.|||.                    
lsgyiNardvggy.............grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywp....................

sttsmrkntmgtqnsslysagvqgnssnystdndndndnnnnnnnnsNIAVTAAACDDDDDDDDDAIL---------------IRKILLTYH-DQEKPYE
                                               .| .    . ||.. .   .                .|..|||.. . ....|
...............................................girylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

LLQIQVKNWPDLGTLLNPisILQAINVKNHiidtlfarnyyqndqLPTILVHCSAGCGRTGTLCTIDSILSNfemfemlqkefvklkypaklfDP-----
.....  .||| |.  ..  .|..... ..                  .|||||||..||||.. .. .| .                      .     
vmhlhytdwpdhgvpqea..llellellld...............ggpvlvHCsaGkdRTGtvvallllllg.....................vsletiv

---------ISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRL
         .  ...  |.||  .||.  |..|.|..|| ..| 
ddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
0051082 (Phosphotyrosine protein) phosphatases II 569-875 9.6e-21 69.4 In-house 3-149 (151) alignment 
Range on Protein: 569-875
Range on HMM: 3-149/151.0
DNYINANYLSlPRfsveqnssfqttttttrrvrYIATQAPMPstvhDFYTCILNNGVPLVLSLTNDFENGieKCYRYWQEGNyngihvkllekkilkmps
..|||..|.  ..                    ......|..    ||.  . ..|.  ...|....|.|  .|..|..| .                  
sdyinfsyvt.gg....................lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................

ttsmrkntmgtqnsslysagvqgnssnystdndndndnnnnnnnnsniavtaaacdddddddddailirkilltyhdqekpYELLQIQVKNWPDLGTLLN
                                                                                  |.|.|.. .||| |. |.
.................................................................................ievlhipildwpdpglpls

PISILQAINVKNHiidtlfarnyyqnDQLPTILVHCSAGCGRTGTLCTIDSILSNfemfemlqkefvklkypaklfDPISWTINIFRKQRISMVQNINQF
. ..|..... ..             ..   .|||||||.||||||. .. .| .                      ..  ... .|..|  .||  .||
fdavleflellld.............kkngpvlvHCsaGkgRTGtlvalylmllg.....................vsleealeeyrlkrpgvvqpnqqf

IFIYDCL
.|.. .|
lfqlfal
0046846 (Phosphotyrosine protein) phosphatases II 570-879 3.3e-26 87.5 In-house 13-173 (176) alignment 
Range on Protein: 570-879
Range on HMM: 13-173/176.0
NYINANYLSLPRfsveqnssfqttttttrrvrYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIhvkllekkilkmpst
.|||||..  .|                    .||||.|.|.|. ||   ....|. .|..||...| |  ||..||.|   .||               
dyinanlilgsr....................piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............

tsmrkntmgtqnsslysagvqgnssnystdndndndnnnnnnnnsniavtaaacdddddddddailirkilltyhdqekpyellQIQVKNWPDLGTLLNp
                                                                                    |... .||| |.    
....................................................................................qylhlpwpDhgvpdl.

ISILQAINVKNHIIdtlfarnyyQNDqlPTILVHCSAGCGRTGTLCTIDSIlsnfemfemlqkefvklkypA-KLFDPISWTINIFRKQRI-SMVQNINQ
  .|....  .  .         ...   ..|||||||.||||||. .. .                      . . ..  ..  .|.||   .||. .|
elllellefireal.........keg..gpvlVHCsaGigRtgtlvaayll....................elekglsveealalvreqRplgavqtpeQ

FIFIYDCLLFYF
  |.|...|...
yrflyefellll
subfamily_PTPN14_pd Subfamily PTPN14 587-679 4e-15 50.6 In-house 80-172 (300) alignment 
Range on Protein: 587-679
Range on HMM: 80-172/300.0
NSSFQTTTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIHVKLLEKKILKMPSTTSMRKNTMGT
|.|   .. ....  ||..|.|.. ||.||. .. ..|| |.. ||.. |.| ||...|. . . .  .|.  . |. .  |..| .  |.| 
nassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittgl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 590-673 1.1e-08 29.2 In-house 80-162 (305) alignment 
Range on Protein: 590-673
Range on HMM: 80-162/305.0
FQTTTttTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIHVKLLEKKI-LKMPSTTSMR
. .|   |   |.| ||||.  |  ||.   |.. |  .. | |  | | .||. |.   . . .. .  ..|| .|. |.....
yvstp..tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 594-647 1.7e-06 22.2 In-house 76-129 (307) alignment 
Range on Protein: 594-647
Range on HMM: 76-129/307.0
TTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQ
 ....  ..|..| |. .|...|.. .... |  |. | .  | .  || .|| 
giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywp
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 595-665 3.4e-07 24.3 In-house 85-155 (301) alignment 
Range on Protein: 595-665
Range on HMM: 85-155/301.0
TTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIHVKLLEKKILK
|. .  |.||||.|...| .||.. .    |  .  |..  |. .|||  |      . ....  . || .
tsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikikn
0043147 (Phosphotyrosine protein) phosphatases II 597-873 4e-24 80.7 In-house 17-155 (172) alignment 
Range on Protein: 597-873
Range on HMM: 17-155/172.0
TRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDfengiekcyrywqegnyngihvkllekkilkmpsttsmrkntmgtqnsslysagvqgnssny
    |.||||.|...|..||.  . ..|. ....||.                                                               
yipdrfiatqgplrntladfwrmlkelgithivnltel..............................................................

stdndndndnnnnnnnnsniavtaaacdddddddddailirkillTYHDQEKPYELLQIQVKNWPDLGTLlNPISILQAINVKNHIIdtlfarnyyQNDQ
                                             .|  .    . .|..  .||| |.  ..  .|....  ....         ....
.............................................lydpellerlgiqylylpwpDhgvp.llellleflefidell.........alsp

LPTILVHCSAGCGRTGTLCTIDSILsnFEMfemlqkefvklkypaklfdPISWTINIFRKQRISMVQNINQFIFIYD
  ..|||||||.||||||. .. .|    .                   ..  ... .|..|  .||| .| .|.|.
ggpvlVHCsaGvgRtgtlvaaylml..lgl...................sleeavalvrekRpgavqnpsqyrflyy
0036282 (Phosphotyrosine protein) phosphatases II 598-873 1.6e-26 88.4 In-house 17-164 (174) alignment 
Range on Protein: 598-873
Range on HMM: 17-164/174.0
RrvRYIATQAPMPstvhdFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEgnyngihvkllekkilkmpsttsmrkntmgtqnsslysagvqgnssnys
.  |.||.|.|..     |.  . ..|.  |..|.. .|.|..||..|| |                                                 
p..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................................

tdndndndnnnnnnnnsniavtaaacdddddddddailirkilltyHDQEKPYELLQIQVKNWPDLGTLLNPIsILQAINVKNHIIdtlfarnyyQNDQL
                                              . .    . .|..  .||| |.   .| .|....  ....         ..|. 
..............................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal.........sedpg

PTILVHCSAGCGRTGTLCTIDSILSNFE--MFEMlqkefvklkypaklfdpiswtINIFRKQR---ISMVQNINQFIFIYD
 ..|||||||.||||||. .. .| . .  . .                      ....|..|     |||. .|..|.|.
gpvlVHCsaGvgRtGtlvaaylmlrglleslvda.....................ldlvrelRlqrpgmvqtpsQyrflyy
0049260 (Phosphotyrosine protein) phosphatases II 599-873 1.2e-24 82.2 In-house 8-144 (152) alignment 
Range on Protein: 599-873
Range on HMM: 8-144/152.0
RVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWqegnyngihvkllekkilkmpsttsmrkntmgtqnsslysagvqgnssnyst
  ..||||.|.| |. ||.  . ..|.  ...||...|.| .||..|.                                                    
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi....................................................

dndndndnnnnnnnnsniavtaaacdddddddddailirkilltyhdqekpyellQIQVKNWPDLGTLLNPISILQAINVKNHIidtlfarnyyQNDQLP
                                                       |..  .||| |.  ... .|... . ...          . |.  
.......................................................qylhlpwpDhgvpdlsqlllflllfiekl..........aldkgg

TILVHCSAGCGRTGTLCTIDSILsnfemfemLQkefvklkypaklfDPISWTINIFRKQRISMVQNINQFIFIYD
..|||||||.||||||. .. .|        |.              ..  ... .|..|  .|.| .| .|.|.
pvlVHCsaGvgRtgtlvaaylml........lg.............vsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPN1_pd Subfamily PTPN1 599-874 2.2e-16 54.4 In-house 70-266 (290) alignment 
Range on Protein: 599-874
Range on HMM: 70-266/290.0
RVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNY-NGIHVK--LLEKKILKMPSTTSMRKNTMGTQNsslysagvqgnssn
. .|| || |.|.||  |.  . ..    |. | .  |..  ||..|| .|.  . . ..   |. |...  ..   . ...  .|              
krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen..............

ystdndndndnnnnnnnnsniavtaaacdddddddddailirkilltyHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINvknHIIDTlfarNYYQND
                                                   ..  |.|.     |||.|    | . |. .    .. ..       ..|
................................................lktqetreilhfhyttwpdfgvpespaaflkflf...kvres....Gslssd

QLPTIlVHCSAGCGRTGTLCTIDSILSNFEMFEmlQKEFVKLKypAKLFDpiswtiniFRKQRISMVQNINQFIFIYDC
. |.. .||||| ||.||.| .|..| . |  .  ... |..|   .| .         ||.|. ..|  .|. | |  
vGpav.ihcsaGiGrsGtfclvdtclvliekkd..dlssvdik..kvlle........lrkyrlGliqtadqlrfsyla
subfamily_CG42327_pd Subfamily CG42327 599-647 3.9e-06 20.8 In-house 71-119 (319) alignment 
Range on Protein: 599-647
Range on HMM: 71-119/319.0
RVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQ
.  |||.|... ..  ||.  . ..    .. ||. .|.||..| .|. 
pnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylP
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 600-649 1.5e-08 28.9 In-house 75-124 (285) alignment 
Range on Protein: 600-649
Range on HMM: 75-124/285.0
VRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEG
  ||.|| |.| |. ||.  | .. .  || |   || |.|||  |. | 
styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 600-650 5.9e-06 20.1 In-house 96-146 (305) alignment 
Range on Protein: 600-650
Range on HMM: 96-146/305.0
VRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGN
 |.|..| |.  |. .|.  ...| |  .. | .  | |  || .||   .
krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq
subfamily_egg_pd Subfamily egg 601-651 7.6e-06 19.8 In-house 84-132 (307) alignment 
Range on Protein: 601-651
Range on HMM: 84-132/307.0
RYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENgiEKCYRYWQEGNY
 .| .|||.  ||.||.  . .. |. .. ||   |.  |.|  ||   . 
efilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaes
0044763 (Phosphotyrosine protein) phosphatases II 603-879 3.7e-18 61.2 In-house 32-171 (178) alignment 
Range on Protein: 603-879
Range on HMM: 32-171/178.0
IATQAPmpstvHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYngihvkllekkilkmpsttsmrkntmgtqnsslysagvqgnssnystdndn
.... |      |..  . ..|. ....||...|.| .||..|| |..                                                    
lgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...................................................

dndnnnnnnnnsniavtaaacdddddddddailirkilltyhdqekpyelLQIQVKNWPDLGTLLNPISILQAINVKNHIIdtlfarnyyqNDQLPTILV
                                                  .| .  ..|| |.   .  .|....  ....          ...  ..||
..................................................iqylhipipDhgvpdllehflefvefieeal..........dekggpvlV

HCSAGCGRTGTLCTIDSILSNfemfemlqkefvklkyP----AklfdpiswTINIFRKQRIsMVQNINQFIFIYDCLLFYF
||||| ||.|||. .. ....                     .         |. .|..|  .|.| .|  ..|.. |...
HCsaGvgRsgtlvaaylmkkl................glslee........aielvrerRp.ivpnpgqlrqLyefelrll
Y_phosphatase Protein-tyrosine phosphatase 707-876 7.4e-25 83.1 Pfam-A 92-234 (235) alignment 
Range on Protein: 707-876
Range on HMM: 92-234/235.0
NNNNNNNSNIAVTAAacdDDDDDDDDAILIRKILLTYHDQEK-PYELLQIQVKNWPDLGtllnpisilqAINVKNHIIDTLFARNYYQNDQLPTILVHCS
... ... .| |.      .  .|.... .||. |. ...|. . |. |....|||| |          . . .....|.. . . .....   ..||||
eeesltygdikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhg..........vpespkslldlirkvekskeaksgpvvVhCs

AGCGRTGTLCTIDSILSNFEM---FEMLQkefvklkypaklfdpiswTINIFRKQRISMVQNINQFIFIYDCLL
||.|||||....| .|...|    ...||                  ... .||||..|||...|.||.|...|
aGvgRtgtfvaldilleqleaeeevdvlq..................ivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 707-876 7.4e-25 83.1 In-house 92-234 (235) alignment 
Range on Protein: 707-876
Range on HMM: 92-234/235.0
NNNNNNNSNIAVTAAacdDDDDDDDDAILIRKILLTYHDQEK-PYELLQIQVKNWPDLGtllnpisilqAINVKNHIIDTLFARNYYQNDQLPTILVHCS
... ... .| |.      .  .|.... .||. |. ...|. . |. |....|||| |          . . .....|.. . . .....   ..||||
eeesltygdikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhg..........vpespkslldlirkvekskeaksgpvvVhCs

AGCGRTGTLCTIDSILSNFEM---FEMLQkefvklkypaklfdpiswTINIFRKQRISMVQNINQFIFIYDCLL
||.|||||....| .|...|    ...||                  ... .||||..|||...|.||.|...|
aGvgRtgtfvaldilleqleaeeevdvlq..................ivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN3_pd Subfamily PTPN3 717-876 7.1e-15 49.7 In-house 140-272 (280) alignment 
Range on Protein: 717-876
Range on HMM: 140-272/280.0
AVTAAACDDDddDDDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIdtlfarnyyQNDQLPtILVHCSAGCGRTGTLCT
.     |  .  | . ....|...|. .....  ..||.|  .||| |   .. ..|. ..  ...          . .. | ..|||||| |||| | .
gefsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.........sgkeeP.vvvhCsaGigrtGvlil

IDSILSNFEMFEMLqkefvklkYPAKLfdpiswtINIFRKQRISMVQNINQFIFIYDCLL
..  |.  |. | .        || ..       .   | || ..||. .|. |. ...|
letalalieaaepv........ypldi.......vrtmrdqramlvqtasqykfvCeail
subfamily_PTPN12_pd Subfamily PTPN12 720-889 7.2e-24 79.2 In-house 143-287 (290) alignment 
Range on Protein: 720-889
Range on HMM: 143-287/290.0
AAACDDDDDDDDDaILIRKILLTYHDQEKpyELLQIQVKNWPDLGTLLNPISILQAINVknhiidtlfARNYYQNDQLPtILVHCSAGCGRTGTLCTIDS
   .....  ||| .||| . .. .....  .. |.. ..||| |.  .. |.|. |.          .|.. .... | ..||||||.|||||...|| 
evtleeekavddd.flirtLkveaqkesr..kvyqfhYtaWPDhgvPssakslleliel.........vrelqesedaP.lvvhCsaGvGrtGtiiaidy

IlsnfemFEMLQKEFVKLKYpaKLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRLDDITER
.       |.|..| .. ..  ..||     .  .|||| ..||  .|. ..| ... ... .|. |.|.
v......rellkaekipeel..dvfd....lvlelrkqraalvqtkeqyelvykavaelvqkeleiieek
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 722-821 4e-08 27.3 In-house 156-240 (290) alignment 
Range on Protein: 722-821
Range on HMM: 156-240/290.0
ACDDDDDdDDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVknhiIDTLfarnyyqndqLPTILVHCSAGCGRTGTLCTIDSIL
 |  .|| .|. |  . . .   |. | . |  ...| |||    |  ...|. . .    . ..             . |||||| |||||. .|.  |
lcseedd.kdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlri....lrka..........sGpvvvhcsaGiGrtGtfvaievgl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 727-879 2.6e-12 41.3 In-house 149-278 (287) alignment 
Range on Protein: 727-879
Range on HMM: 149-278/287.0
DDDDDDAILIRKILLTYHD-QEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNhiidtlfaRNYYQNDQLpTILVHCSAGCGRTGTLCTIDSILSNFE
...  .  ..||. .. .. .... .. | |. ||.. | . .| .||  |. ..        .. ... .  .|.||||.. ||....| ..  . . .
neevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy........ktqrkrgnt.sivvhCsdtvGrsamfcaaattinkck

mfemlqKEFVklkypaklFDPISwTINIFRKQRISMVQNINQFIFIYDCLLFYF
      .| |         | ..  ..  | |.  .|| ..|..||.| .| | 
......teGv........iDvfq.vlksqriqkpgsvqtveqykfindivleyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 727-880 1.4e-11 39.0 In-house 155-278 (307) alignment 
Range on Protein: 727-880
Range on HMM: 155-278/307.0
DDDDDDAILIRKILLTYHDQEKpyELLQIQVKNWPDLGTllnPISILQAINVknhiidtLFARNYYQNdqlPtILVHCSAGCGRTGTLCTIDSIlsnfeM
   |.| | . .. . . .. .   . ..| .|||| |.   |   | |||.       | | .| .|   | ..|||||| ||.||. .|  .     .
lapdedlinvttlkvdwaqksr..tiqhlqwenwpdrgv...pqinltainl.......leavrydtn...p.vvvhcsaGvGrsGtivaislv.....q

FEMLQKEFVKlkYPAKLfdpiswtINIFRKQRISMVQNINQFIFIYDCLLFYFR
  |.. .  |     ||       .. .|.||   .|.  |.....  || || 
dkmiaGinck..dmkkl.......veelrsqrhyaiqteaqylylhrvlleyfl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 728-876 2.3e-16 54.7 In-house 155-276 (288) alignment 
Range on Protein: 728-876
Range on HMM: 155-276/288.0
DDDDDAILIRKILLTyhDQEKPYELLQIQVKNWPDLGtllNPISILQAINVKNHIiDTLFARNyyqndqLPTILVHCSAGCGRTGTLCTIDSILSNFEMf
. . . .. ||.||    ... .|. | | . ||| |    | |  . ... . . ..    .      .  |.|||||| |||||  ..| .. . |  
skeledfvlrkllle..kkkteleitqyqylaWpdhg...vPeskapllellrqv.kvanqad......tgpiivhCsaGvGrtgtFialdalidavee.

emlqkefvklkypAKLFDpISWTINIFRKQRISMVQNINQFIFIYDCLL
              .  | .  |.. .|||| ..||. .|..|||..||
.............edyiD.vagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 728-879 2e-14 48.3 In-house 155-279 (315) alignment 
Range on Protein: 728-879
Range on HMM: 155-279/315.0
DDDDDAILIRKILLTYHDQEKpyELLQIQVKNWPDLGTLLNPISILQAINVknhiidtlfARNYYQNDQlPTILVHCSAGCGRTGTLCTIDSILSNFEMF
..  . . .| .  .. |. .  |..|...  ||| |     |.... |           .. . .|.   .|.|||||| |||||..|.|..| . |. 
eevnteytvrtlsvvfgdnir..evvqlhytswpdmgvpkytiplmnlirt.........vkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeae

EMLQkefvklkypakLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFYF
...            ...     |.  |..|| ||| ..|. |||| ||  |
naid...........vyn....fitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 728-880 3.4e-14 47.6 In-house 149-277 (281) alignment 
Range on Protein: 728-880
Range on HMM: 149-277/281.0
DDDDDAILIRKILLtYHDQEKPYELLQIQVKNWPDLGTllnPISILQAINVKNHIidtlfaRNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILSNFEmf
  .    . ||. | .... .. |. |.. ..||| |    | .  . .. .. .      ... ....  ....||||| |||||  ..| .... |  
eeekatyierkfkl.eresgetreveqlaytaWPdhGv...Pattkellefrkev......lkltekktkaplvihCsaGvGrtGtyialDrlvkave..

EMLQKefvkLKypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYFR
..|..    |.        .. ... .||.|  ||| . |. |.|  .| .. 
aelee....ld........vkavvaelrkernlmvqtvvqyefvykavldald
0040438 (Phosphotyrosine protein) phosphatases II 729-884 2.7e-27 91.3 In-house 151-281 (317) alignment 
Range on Protein: 729-884
Range on HMM: 151-281/317.0
DDDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIdtlfarnyyQnDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFE
. .. | .|.. ..... ... .. ... ..||| |.  .| ..|. ..  .. .         . |.   .|||||||.|||||..... .|. .|  .
eelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal.........e.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg

MLQkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRLD
 .                .  ... .|.||  .||. .|..|.||.||.|.. .| 
gvd...............veeavkelreqRpgavqtpeqyrflydalleylkrklt
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 729-880 3e-08 27.6 In-house 168-290 (305) alignment 
Range on Protein: 729-880
Range on HMM: 168-290/305.0
DDDDAILIRKILLTYHDQEKpYELLQIQVKNWPDLGTllnPISILQAINVKNHIidtlfarnyyQNDQLPtILVHCSAGCGRTGTLCTIDSILSNFEmfE
. |  | |  . |||  ..|   . ..|  .||| |    |   | ....   |          .  ..| |.|||||| |||||. .|. || .    |
erdaeiqitllnltysgdqk.msvrhlqwtewpdrgv...ppckltslellsai..........rgskvp.ivvhcsagigrtgtivaieyilekia..e

mlqkefvklkypAKLFDPISWTINIFRKQRISMVQNINQFIFIYDCLLFYFR
             |   |.   .. .| ||   .||  |..||.  .| || 
............nkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 729-876 1.4e-07 25.7 In-house 145-292 (297) alignment 
Range on Protein: 729-876
Range on HMM: 145-292/297.0
DDDDAILIRKILLTYHDQEKpyELLQIQVKNWPDLGTL--LNPISIL--------QAINVKNHIIDTLFARNYYQNDQLP-------TILVHCSAGCGRT
|. | . . .. | | ....   .  .|  .||| |    |. .  .         |. .   ... . |  . | . |         .||||||| ||.
defdrviltelqliyrsesr..vvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrs

GTLCTIDSILSnfemfeMLQKEFVklkyPaklfdPISWTINIFRKQRISMVQNINQFIFIYDCLL
| .   | ||.      .|.|...    |      .   ..| |.||  .|| ..|| ..||  |
Gvvvlsdvila......klrkkri....p.....dvaailsilreqrarlvqtleqfellydavl
0039614 (Phosphotyrosine protein) phosphatases II 730-883 2.4e-26 88.3 In-house 165-293 (297) alignment 
Range on Protein: 730-883
Range on HMM: 165-293/297.0
DDDAILIRKILLTYhdQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLfarnyyqnDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEM
 .| . .|.. .|.   ...... ..|. .||| |.  .. ..|....  .... .|        ..   .|||||||.|||||..... .|. .|    
hldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealael........pkggpvlVHCsaGvgRtGtfiaaylmleqlekegg

LQkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRL
.                .  ... .|.||  .||. .|..|.||.||.... .|
vd...............vleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_PTPN13_pd Subfamily PTPN13 730-876 9.3e-18 59.5 In-house 146-266 (273) alignment 
Range on Protein: 730-876
Range on HMM: 146-266/273.0
DDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIidtlfarnyyQNDQLPtILVHCSAGCGRTGTLCTIDSIlsnfemFEM
. |.  .|.. ..  . ..  |. ...  .||| |.  .. ..|| .   ...          |.|..| |.|||||| ||.||| ||| .      ...
kldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl..........qtdagP.ivvhcsaGiGrsGtlitidvv......lgl

LQKEFvklkypakLFdPISWTINIFRKQRISMVQNINQFIFIYDCLL
....          | ... ... .|.|| ..||  .|.||.|  .|
ierdk........ef.dvkeivrklreqrqgvvqtkdqyifvykail
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 730-878 4.2e-16 53.9 In-house 155-279 (318) alignment 
Range on Protein: 730-878
Range on HMM: 155-279/318.0
DDDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIidtlfarnyYQNDQLPTILVHCSAGCGRTGTLCTIDSILSNfemfem
. .  ..|.. .| ...|.  .  | .. .||| |.. .. |.|. .   ...          |. .  .|.|||||| ||||. ...|..|        
elsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska.........qqksgagpivvhCsaGvGrtGvfiavdiller......

LQKEfvklkypaKLFDpISWTINIFRKQRISMVQNINQFIFIYDCLLFY
...|        .| | .  |.. .|.||  |||  .|..|||| || .
ikae........alvD.vfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 730-879 1.9e-13 45.2 In-house 157-283 (319) alignment 
Range on Protein: 730-879
Range on HMM: 157-283/319.0
DDDAILIRKILLTYHDQEK-PYELLQIQVKNWPDLGTllnPISILQAINVKNHIidtlfaRNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILsnfemfE
  . . |||. |  . .|    |. . | ..||| .    | . .. ... ..|      |.  .. |   | |||||| ||||| ...| .|      |
eledyiirklklnkkssevetRevkhfqyteWpdhdv...Pekatslldllkri......rksrektqsgPivvhCsaGvGRtGtfivldaml......e

MLQKEfvklkypaKLFDpISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
 ...|         . | .  |..  | ||  |||. .|..|||. || . 
rvkee........gvlD.vfstvsrlRtqRnimvqrpeqYkfiyealleav
0043336 (Phosphotyrosine protein) phosphatases II 731-879 6.6e-26 86.8 In-house 154-277 (278) alignment 
Range on Protein: 731-879
Range on HMM: 154-277/278.0
DDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDtlfarnyyqnDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEML
.| . .|.. .|..   .... .... ..||| |.  .. ..|. ... .....          |.   .|||||||.|||||..... .|. .|    .
lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..........dsngpvlVHCsaGvgRTGtfialyllleqlekeggv

QkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
                .  ... .|.|| ..||. .|..|.|..||.|.
d...............leeavkelreqRpgavqtpsqyrflyealleyl
0040439 (Phosphotyrosine protein) phosphatases II 731-879 1.2e-24 82.7 In-house 121-246 (249) alignment 
Range on Protein: 731-879
Range on HMM: 121-246/249.0
DDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLfarnyyqnDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEML
 | . .|.. ||..   .... |.||. .||| |.  .. ..|. |.  ......|        ..   .|||||||.|||||..... .|. .|    .
kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel........pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgv

QkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
                .  ... .|.||  .||| .|..|.|..||...
d...............leeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN14_pd Subfamily PTPN14 731-879 2.5e-13 44.7 In-house 164-296 (300) alignment 
Range on Protein: 731-879
Range on HMM: 164-296/300.0
DDAILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARNYYqNDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEML
 |..  ... | .   ..  ... .| ..||| |   .. . |. ..  . .       .   ... | .||||||| |||| | . | ... .|  | .
sdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves.keskPPvlvhCsaGvGrtGvlilsdlliatlehneei

QkefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
.               |  .... |.|| ..||.. |. |.|. |. |.
d...............ikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_ptpA1_pd Subfamily ptpA1 731-822 2.4e-07 24.8 In-house 169-254 (418) alignment 
Range on Protein: 731-822
Range on HMM: 169-254/418.0
DDAILIRKILLTYHDQEKpyELLQIQVKNWPDLGTllnpISILQAINVKNHIIDTLFARNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILS
.  |. |.| ||.  . .  .. | | . |||           | .    | |     .    .|.   |.|||||| |||||.||   .. 
ereiitrnirltfegetr..ditqyqyegwpdhni....pdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_PTPRA_pd Subfamily PTPRA 732-879 1.3e-16 55.4 In-house 169-295 (330) alignment 
Range on Protein: 732-879
Range on HMM: 169-295/330.0
DAILIRKILLT----YHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHiidtlfaRNYYQNDqlpTILVHCSAGCGRTGTLCTIDSILsnfemf
 .. .||.|..      ...|.  . |.  . |||.|   .|| .|. ..  ..        |  . .   .| |||||| |||||....|..|      
vdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk.......lnqqsag...pivvhcsaGvGrtGtfivldavl......

EMLQKEFVkLkypaKLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFYF
|... | . .     .|.    ... .|.||  |||  .|. |||  || |.
ervkaerk.v....dvfe....fvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 732-882 1.1e-13 45.7 In-house 136-267 (270) alignment 
Range on Protein: 732-882
Range on HMM: 136-267/270.0
DAILIRKILLTyhDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARNYYQNDQlPtILVHCSAGCGRTGTLCTIDSILSNFEMfemLQ
.  ..... |.  .. .  .|.  . ..||| |   .. | |.. .. . . .    ..  .. . | .||||||| |||||| ..| ..   |.    .
egyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.P.llvHcsaGvgRtGtlialDiavrlLee...tk

KefvklkypaklFDPISwTINIFRKQRISMVQNINQFIFIYDCLLFYFRLR
|            |...  |.  ||.|. .||  .|. |.|  .. | . |
k...........vdvla.iieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 733-879 5.4e-15 50.4 In-house 168-290 (298) alignment 
Range on Protein: 733-879
Range on HMM: 168-290/298.0
AILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINvknhiidTLFArNYYQNDQLPtILVHCSAGCGRTGTLCTIDSILsnfemfEMLQK
 . .||. .. ...||  |. |... .||| |.  |  |.|. ..          | . .|. . | ..|.|||| ||.|| . |||.|      | ..|
dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr.......kvra.sqqqagnkp.vivqCsaGvgRsGtfiaidsvl......ervkk

EfvklkypaKLFDpISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
|        .  | .  .....||.|. .||  .|..|||.  | ..
e........qvvD.vfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPN23_pd Subfamily PTPN23 733-880 1.7e-14 48.3 In-house 154-281 (288) alignment 
Range on Protein: 733-880
Range on HMM: 154-281/288.0
AILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARNYYqndqlpTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQk
    |.. |. .|... ...  .|...||.||    | ..|| ... ..  ..   .          ..|||||| ||||... . ... ..|  . |  
thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt......PlvvhCsaGvgRtgvfalvyaavrelekgngll.

efvklkypaklfdPISWTINIFRKQRISMVQNINQFIFIYDCLLFYFR
              |   .. .|.||  |||. .|. | |.  | . |
.............diiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 734-877 1.2e-13 46.0 In-house 168-289 (319) alignment 
Range on Protein: 734-877
Range on HMM: 168-289/319.0
ILIRKILLTYHDQEK-PYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTlfarnyyqNDQLPTILVHCSAGCGRTGTLCTIDSILSnfemfeMLQK
  .|.| |. . .||   .. |   . ||| |    |. ... ..  .|. .         ...   |.||||||.||||.  ..| .|.      ....
yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk........enhranivvhcsaGvGrtGvyivldvlld......rmke

EfvklkypaKLFDpISWTINIFRKQRISMVQNINQFIFIYDCLLF
|        |  | .  ... .|.||  .||.. |. |||  || 
e........kqvd.vynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 734-877 1.7e-13 45.7 In-house 132-253 (284) alignment 
Range on Protein: 734-877
Range on HMM: 132-253/284.0
ILIRKILLTYHDQEK-PYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTlfarnyyqNDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQk
  .|.| |. . .||   .. |   . ||| |    |. ... ..  .|. .         ...  .|.||||||.||||.  ..| .|. ..  .... 
yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk........enhranivvhcsagvgrtgvyivldvlldrmkeekqvd.

efvklkypakLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLF
          ...    ... .|.|| ..||.. |. |||  || 
..........vyn....fvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 734-882 6e-13 43.3 In-house 159-280 (315) alignment 
Range on Protein: 734-882
Range on HMM: 159-280/315.0
ILIRKIllTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAIN-VKnhiidtlfARnyyQNDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQk
  .||.  .  . |.   . | | ..||| |.  .  |.|. |  ||        |    .. .  ..||||||| |||| ...||..... .  ...  
gvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevk........ad...ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvd.

efvklkypakLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFYFRLR
          .|.    .....|..|. .||  ... |||| .| ..  |
..........vfn....fvknlrakrpylvqteeeyafiydavledllwr
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 734-878 6.9e-13 43.4 In-house 121-241 (250) alignment 
Range on Protein: 734-878
Range on HMM: 121-241/250.0
ILIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQainVKNHIidtlFARNyYQNDQLPtILVHCSAGCGRTGTLCTIDSILsnfemfEMLQKE
. .||. |. . ...   . |..  .||| |   .  ..|.   .....     | .  | .. | ..|.|||| ||.|. ..||..|      | |.||
ytkrklklskakkaderivrqlhfvvWPdkgvPevatavLe...llkkv....qasq.qqagnaP.vivqCsaGvgrsGafiaidavl......erlkke

fvklkypaKLFDpISWTINIFRKQRISMVQNINQFIFIYDCLLFY
        |  | .   |...||.|. .|.  .|..|.|  .| .
........kvvd.vfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 735-878 3.7e-16 54.1 In-house 162-282 (305) alignment 
Range on Protein: 735-878
Range on HMM: 162-282/305.0
LIRKILLTY-HDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVknhiidtLfaRNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILsnfemfEMLQKE
..||. ..  .....   .|| |. .||| |    . |.|. |.        .  .. ...|.  ..||||||| ||||. ...|  |      | |.||
ieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikr.......v..qkdqkkdkgvpllVhCsagvgRtGvfiavdial......erlkkE

FVklkypAKLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFY
 |       .|.     ..  |..|. |||. .|. |..| |  .
ev.....vdvfe....vlkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPN9_pd Subfamily PTPN9 735-879 3.6e-15 50.7 In-house 158-290 (297) alignment 
Range on Protein: 735-879
Range on HMM: 158-290/297.0
LIRKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPISILQA---INVKNHIIDTLFARNYYQNDQLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQ
 .|.. ..  ..|.  ..   |.  ||| |.  .  |.|.    .  |   . . .. .   . . | |.|||||| |||||..|.|  ||..|. ....
kvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvd

kefvklkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCLLFYF
               .  |.. .|.||  ..|  .|. | | ..| | 
...............vvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 735-882 6.7e-12 39.3 In-house 159-279 (515) alignment 
Range on Protein: 735-882
Range on HMM: 159-279/515.0
LIRKILLTYHDQekPYELLQIQVKNWPDLGTLLNPISILQAIN-VKNhiiDtlfaRNYYQndqlPTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLQke
..||. ..  |.     . | . ..||| |.  .  |.|. |  ||    |    .. |.     ....||||| |||| ...|||.... .  .|.   
ikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevka...d....hgqyt....hpliihcsaGvGrtGvvisidsvvahakttrmvd..

fvklkypakLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFYFRLR
         .|.    .... |..|  .||  .|. |||. .| ..  |
.........vfn....fvtnirqkrpylvqtqeqyafiygavledllwr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 735-875 4.9e-07 23.9 In-house 146-262 (283) alignment 
Range on Protein: 735-875
Range on HMM: 146-262/283.0
LIRKILLTYHDQEKPYE-LLQIQVKNWpdlgTLLNPISILQAINVKNHIIdTlfarNYYQNDQLPtILVHCSAGCGRTGTLCTIDSILSnfemfEMLQKE
 |...|| .    |    |   || .|    .  .. .|. ..   | .| .    .  .. . | |.||||.| |||...... . .      ..| . 
iikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvi.s....lqteskkgP.ivvhCstgiGrtavfiaasasvk.....daltes

FVKlkypaklfdpISWTINIFRKQRISMVQNINQFIFIYDCL
 |           .  ...| |.||. .||. .|. ....  
vvd..........vfavvkimreqrmmavqtldqyklvhelv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 735-823 4.2e-06 21.1 In-house 117-198 (237) alignment 
Range on Protein: 735-823
Range on HMM: 117-198/237.0
LIRKILLTYHDQEKPYELL-QIQVKNWPDLGTLLNPISILQainVKNHIIDtlfaRNYYQNDQLPTIlVHCSAGCGRTGTLCTIDSILSN
 .| .||... . |   |. | |   ||| |   .  ..|.    . .||.    |. . ..  | | .||||| |||| .  ||..| .
tvrslllskrltlkevrlihqyqftswpdrgvpqqtaallr...frkniin....rsphvsesgpwi.ihcsagvgrtgiflvidamlrq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 737-880 1.9e-06 21.9 In-house 155-278 (287) alignment 
Range on Protein: 737-880
Range on HMM: 155-278/287.0
RKILLTYHDQEKPYELLQIQVKNWPDLGTLLNPIS-ILQAINVKNHIIdtlFARNyyQNDqLPTILVHCSAGCGRTGTLCTIDSILSnfeMFEMLQKefv
| . |   . ..   . |... .||| .     .. |  ...||.||     ||.   ..    ..||...| ||.|.| ..  ..|   . | | .   
ralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie...lard..ase.vGPlvvhddvGiGrsGillatlvlvs...rledlGr...

klkypaklFDPISwTINIFRKQRISMVQNINQFIFIYDCLLFYFR
         |.   ..  .|..| ..|| . |. ..|. |  |..
........vdvaa.vvirlreyraalvqavvqlrllyealvtyyk
0048076 (Phosphotyrosine protein) phosphatases II 742-878 3.4e-14 48.2 In-house 37-142 (145) alignment 
Range on Protein: 742-878
Range on HMM: 37-142/145.0
TYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTlfarnyyqnDqlPTILVHCSAGCGRTGTLCTIDSILSnfemfemlqkefvklkypa
|.  .    . .|..  .||| |.   .  .|....  .....          .    .|||||||.||||||. .. .|.                   
tselellerlgiqylylpwpDhgvpdllellleflefieealke.........g..gpvlVHCsaGvgRtgtlvaaylmll...................

kLFDPISWTINIFRKQRISMVQNINQFIFIYDCLLFY
 |  ..  ... .|.||  .|.| .|..|.|...| .
.lgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 742-873 2e-13 45.8 In-house 39-139 (144) alignment 
Range on Protein: 742-873
Range on HMM: 39-139/144.0
TYHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIidtlfarnyYQNDqlPTILVHCSAGCGRTGTLCTIDSILsnfemfemlqkefvklkypa
.|. ..   | .|..  .||| |.   .  .|....  ...         ....    .|||||||.||||||.... ..                    
eyepefleregiqylhlpwpDhgvpdllellleflefieea.........leeg..gpvlVHCsaGvgRtgtlvaaylmk....................

KLFDPISWTINIFRKQRISMVQNINQFIFIYD
||  ..  ... .|..|  .|.| .|..|...
klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPRK_pd Subfamily PTPRK 743-876 1.6e-11 38.6 In-house 166-274 (314) alignment 
Range on Protein: 743-876
Range on HMM: 166-274/314.0
YHDQEKPYELLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTlfarnyyqndQLPTILVHCSAGCGRTGTLCTIDSILsnfemfEMLQKEFVklkypak
 . ||.  |. |.|  .||| ..  .  ..|. .   ..  .           .   |.||||||.||||| ..||..|      .|...| |       
argqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..........eaGrivvhCsaGaGrtGtfiaidivl......dmieregv.......

lFDpISWTINIFRKQRISMVQNINQFIFIYDCLL
  | .  ..  .|.... ||.  .|..|||| .|
.vd.vfnavktlrsrkvnmveteeqykfiydvil
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 747-876 4.4e-11 36.9 In-house 171-276 (439) alignment 
Range on Protein: 747-876
Range on HMM: 171-276/439.0
EKPYELLQIQVKNWPDLGTllnPisiLQAinvkNHIIDTLFARNYY-QNDQLPTILVHCSAGCGRTGTLCTIDSILsnfemfEMlqkefvkLKYPAKLfD
||   .||..   |||      |    ||     |..| | | |   ....   ..|||||| |||||. ..|  |      |        ||   |. |
ekertvlqfhyiawpdknv...p...aqa....shvldflrainsandkeeygpvvvhcsagvGrtGtiialdial......eq.......lklenkv.d

pISWTINIFRKQRISMVQNINQFIFIYDCLL
 |   ....||||  |||.. |..|||...|
.ikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 752-879 2.6e-11 38.2 In-house 180-288 (325) alignment 
Range on Protein: 752-879
Range on HMM: 180-288/325.0
LLQIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARNyyqnDQLPTILVHCSAGCGRTGTLCTIDSILSnfemfEMLQKEFVklkypaKLFDpiswTI
. | |.. |.|.|.   | ...  ... ... ... |           |||||||| ||||.. .. |.|      .....  |       .|.     .
vkqfqlqswddmGvqkrpatlisilqlvkavservtant....kastpilvhcsaGvGrtGvfislysala.....kvieesrv......difg....fv

NIFRKQRISMVQNINQFIFIYDCLLFYF
. .||.| |||. ..|.|.||..|  ..
kklrkdrpsmvetvdqyiliyealveay
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 752-891 6.5e-07 23.0 In-house 91-211 (440) alignment 
Range on Protein: 752-891
Range on HMM: 91-211/440.0
LLQIQVKNWPDLGTLLNPISILQAINVKNHiidtlfARNYYQNDqlpTILVHCSAGCGRTGTLCTIDSILSNFEMFEMLqkefvklkypaklfDPISwTI
| | . . ||| |       .|. |.  |.      ...   |     .|||||||.|||| . ..|||| . .  . .              | .|  |
lkqyhyqgwpdkgvpkfagpvlkmiqdvne......sqekagng...pllvhcsagagrtgviiavdsilreakrsdqi..............difs.fi

NIFRKQRISMVQNINQFIFIYDCLLFYF----R-LRLDDITERTD
| .|..|  |||  .|. |.....|  .      .  |||||| .
nsmrnnrpqmvqtpeqyafvheavlegllcgdtliledditerve
PTPc_DSPc_SM00012 753-876 6.9e-26 85.9 In-house 3-104 (105) alignment 
Range on Protein: 753-876
Range on HMM: 3-104/105.0
LQIQVKNWPDLGTLL---NPISILQAINVKNHIIDTlfarnyyqndqLPTILVHCSAGCGRTGTLCTIDSILSNFEMFEmlqkefvklkypakLFDPISW
 ......||| |.     . ...|.|.. ... ...            . ..||||||.|||||....| .|...|  .               .. |..
khyhytgwpdhgvPeesdsilellravkknknkses...........skpvvVhCsaGvgRtgtfvaldillqqleket..............kevdifq

TINIFRKQRISMVQNINQFIFIYDCLL
... .|||| .|||. .|..|.|..||
ivkelrkqRpgmvqteeqylflyrall
subfamily_CG42327_pd Subfamily CG42327 779-878 2.6e-08 27.9 In-house 229-314 (319) alignment 
Range on Protein: 779-878
Range on HMM: 229-314/319.0
KNHIIDT-LFARNYYQNDQLPtILVHCSAGCGRTGTLCTIDSILSNFEMfemlqkefvklkyPAKLFDpISWTINIFRKQRISMVQNINQFIFIYDCLLF
 .| |.  . .|.  ...| | . |||| | ||||.. . |  . ..|              . .  | |  ..   |..| | |....|. |||  |  
ssheingnissrsgtresqGP.lvvhcsdGvGrtGlviasdiairslee.............skrsvd.iPqlvssvrrdrasavltkeqyefiykvlse

Y
|
y
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 785-883 1.1e-08 29.5 In-house 181-263 (267) alignment 
Range on Protein: 785-883
Range on HMM: 181-263/267.0
TLFARNYYQNDQLPtILVHCSAGCGRTGTLCTIDSILsnfemfEMLQKEFVklkypAKLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRL
 ..|.|  .| . | ..|.||.| ||.||. .||| |      | ...| |     ...||     .   |.|||..|.  ...|.|.. |  | . ||
gilaknqlengnrP.lvvacsdGvGrsGtflvidsql......eraktegv.....sdifd....flrkirsqriglvdtkeryiyihellaeyaegrl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 788-878 1.1e-10 36.1 In-house 209-283 (297) alignment 
Range on Protein: 788-878
Range on HMM: 209-283/297.0
ARNYYQNDQLpTILVHCSAGCGRTGTLCTIDSILSNfemfeMLQKEFVklkypaKLFDpiswTINIFRKQRISMVQNINQFIFIYDCLLFY
  .. || .   .||||.|| |||| |.||||....     . ... |       .|.    ... .|..|  .||  .|. |.|  .| .
rkdfsqnaeg.PllvhclaGvGrtgvlltidsvvae.....akrekev......difg....lvkklrqerpylvqtkeqykfvyvavlea
0038934 (Phosphotyrosine protein) phosphatases II 788-815 7e-06 21.3 In-house 106-133 (194) alignment 
Range on Protein: 788-815
Range on HMM: 106-133/194.0
ARNYYQNDQLPTILVHCSAGCGRTGTLC
.  ....|.  ...||| || ||||||.
vdeflnedpggvvaVHCkaGlgRtGtlv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 794-878 4.5e-06 20.6 In-house 207-275 (312) alignment 
Range on Protein: 794-878
Range on HMM: 207-275/312.0
NDQLPtILVHCSAGCGRTGTLCTIDSILSNfemfemlqkefvkLKYPAKlfDPISWTINIFRKQRISMVQNINQFIFIYDCLLFY
.|. | .. ||||| ||||||. |.|...              |..| |  . .  .  ..||.|   |. . |...   |.| .
kdkkp.viahcsagvgrtgtlaliesmiaa.............lrhprk..qnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_PTPRN_pd Subfamily PTPRN 797-875 1.3e-07 25.7 In-house 224-288 (297) alignment 
Range on Protein: 797-875
Range on HMM: 224-288/297.0
LPTILVHCSAGCGRTGTLCTIDSILSnfemfemlqkefvKLKYPAKLFDpISWTINIFRKQRISMVQNINQFIFIYDCL
  .|.||||.|.||||. . || .|.             .|.  .|  | |. |.. .| ||  .|.  .|| |.. ..
scpivvhcsdGaGrtGvyilidlvln.............rllkGvkeid.iaatlehlrdqrpglvktkdqfefaltav
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 801-876 2.1e-06 22.0 In-house 2-62 (69) alignment 
Range on Protein: 801-876
Range on HMM: 2-62/69.0
LVHCSAGCGRTGTLCTIdsilsnfeMFEMLQkefvkLKyPAKLFDpISWTINIFRKQRISMVQNINQFIFIYDCLL
.||||.| |||||. .|        | || .     .|   || | |   ..  || |  || | ...|||.| | 
vvhcssgtgrtgtfiai........mvemar.....ik.seklvd.ifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 802-876 1.9e-06 22.1 In-house 2-61 (69) alignment 
Range on Protein: 802-876
Range on HMM: 2-61/69.0
VHCSAGCGRTGTLCTIdsilsnfeMFEMLQkefvkLKyPAKLFDpISWTINIFRKQRISMVQNINQFIFIYDCLL
||||.| |||||. .|        | || .     .|   || | |   ..  || |  || | |...||.| | 
vhcssGtGrtGtfiai........mvemar.....ik.seklvd.ifnnvqymrkcrpmmvmneneymfihdalv