Gene SDP1 in Saccharomyces cerevisiae

Synonym: YIL113W, SDP1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily MSG5
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP035_AA protein Get Run
ScerP035_AA_57-198 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MSG5_pd Subfamily MSG5 35-199 1.4e-102 333.8 In-house 1-165 (165) alignment 
Range on Protein: 35-199
Range on HMM: 1-165/165.0
KESPNEDREFVPCSSLDVRRIYPKGPLLVLPEKIYLYSEPTVKELLPFDVVINVAEEANDLRMQVPAVEYHHYRWEHDSQIALDLPSLTSIIHAATTKRE
|||||||.|.|....|||||.|..|||||||||.||||||..||||.||.|||||.|.|||...||||.|.|..|||||.|..||..||.||||||.||.
kespnedielvhaeildvrrvyldgpllvlpeklylysepklkellsfdlvinvakeindlellvpavkyyhiewehdskivkdlsrltriihaatskrk

KILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALNAKTN
|||.||||||||||.||.||||||.|||||..||.|||.||.|.||||||||||||||||..|.|
kilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskksn
PTEN_1 35-189 1e-15 53.1 In-house 10-186 (196) alignment 
Range on Protein: 35-189
Range on HMM: 10-186/196.0
KESPNEDREFVPCSSLDVRRI----YPKGPLLV-LPEKIYLYSEPTVKEL------LPFDVVINVAEEAND------LR-MQVPAVEYHHYRWEHDS--Q
|. . .. |.. ...   |.|     |  |||  ..|. |. |.. | ..        .  |.|..|| ..      |.  .   |||.|. .| .    
kknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgaps

IALDLPSLTSIIHAATT--KREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLME
..  .  . |.|...    .....|.||. ||.||.|...|| |....|. .   .|....  ...| ..   .|.|
lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlle
0044763 (Phosphotyrosine protein) phosphatases II 41-197 4.1e-27 90.4 In-house 4-173 (178) alignment 
Range on Protein: 41-197
Range on HMM: 4-173/178.0
DREFVPCSSLDVRRIYPKGPLLVLPEkIYLYSEPTVKEL-----LPFDVVINVAEEANDLRMQVPA-------VEYHHYRW--EHDSQIALDLPSLTSII
.  .. ..  .. |... ..  .||  .|| | |... |     | .....|..||    ... ..       ..|.|. .   .. ..   .. .. .|
rtrvllsnleglersdyinaseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefi

HAAT-TKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADkINPSIGLIFQLMEWEVALNAK
..|  .| ...|.||..|..||.||..||.||...||| . ..|...|   |.|. | . ||.|.|  |...
eealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
0049772 (Phosphotyrosine protein) phosphatases II 55-196 4.5e-22 74.6 In-house 124-275 (314) alignment 
Range on Protein: 55-196
Range on HMM: 124-275/314.0
IYP------------------KGPLLVLPEKIylySEPTVKELLPFDvvinvaEEANDLRMQVPA-VEYHHYRWEHDSQ-IALDLPSLTSIIHAAtTKRE
|..                  | ||| |...    .|||...|  .       || .|      . ..|... .. .|. .  |....  .|..|  | .
ivmsrdevladelsrLdaAlgKtpllildgng...neptaadlellk......eelydpelferlgikylripvpDgsaplledfdeflefieea.dkgg

KILIHCQCGLSRSAT-LIIAYIMKYHNLSLRHSYDLLKSRADkINPSIGLIFQLMEWEVALNA
..|.||. | .|..| ...||.||....||.  .. ....   |||. |.| ||...|  |.|
pvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilea
0037934 (Phosphotyrosine protein) phosphatases II 55-192 4.1e-17 58.0 In-house 33-239 (243) alignment 
Range on Protein: 55-192
Range on HMM: 33-239/243.0
IYPKGPLLVLPEKIYLYSEPTVKELLP-------------FDVVINVAEEA------------------------------------------ND-LRMQ
 |  . |   ...... . |. . .               ..|.... |.                                            |    .
dyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddlt

VPAVEYHHYRWEH----D--SQIALDLPSLTSIIHA-----ATTKREKILIHCQCGLSRSATLIIAYIMKYH-NLSLRHSYDLLKSRADK-INPSIGLIF
   . ||.. | .    |  ...   |  ....|..     |  . ...|.||  |..|..|||.||.|... ...| . ..||...    . .. . . 
rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyr

QLMEWEV
.|.|.. 
flyeall
0046846 (Phosphotyrosine protein) phosphatases II 56-194 2.3e-18 62.0 In-house 7-172 (176) alignment 
Range on Protein: 56-194
Range on HMM: 7-172/176.0
YPKGPLLVLPEKIYLYSEP----------------TVKELlPFDVVINVAEEANDLRMQVPA---------VEYHHYRWE-HDSQIALDLPSLTSIIHAA
.. ..|  ......| | |                 .|||  ...|.|. ||    | ..|          ..|.|. |. |.     .|..|  .|. |
gldldldyinanlilgsrpiatqgplprtladflemlkel.gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirea

TTKREKILIHCQCGLSRSATLIIAYIMKY-HNLSLRHSYDLLKSRAD-KINPSIGLIFQLMEWEVAL
 .. ...|.||. |..|..||..||.... ..||. . ..|....   .. .. . . .|.|.|  |
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_STYXL1_pd Subfamily STYXL1 59-195 1.2e-20 67.4 In-house 10-154 (157) alignment 
Range on Protein: 59-195
Range on HMM: 10-154/157.0
GPLLVLPEKIYLY-----SEPTVKELLPFDVVINVAEEANDLRMQVPA-VEYHHYRWEHD--SQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATL
 |  |||.|.||       .|..|. |    ..||. .|..|   |.  ..  | . | .  ...   |  . . |.   .. | .|.  . |.||||..
yPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaav

IIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALN
||||.| .....|...|. ||   . ..|  ... || |||  | 
iiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
0048179 (Phosphotyrosine protein) phosphatases II 60-191 1.1e-22 75.8 In-house 4-141 (144) alignment 
Range on Protein: 60-191
Range on HMM: 4-141/144.0
PLLVLPEkIYLYSEPTVKELLP-----FDVVINVAEEANDLRMQVPAVEYHHYRWEHDS--QIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLII
|  .||  .|| | ||...|       .. |||..||     . .. ..|.|. |.  .  ... .|...  .|..|  . ...|.||..|..|..||..
pseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWE
||.||...||| . ..|..||   ..|. | . .|.|.|
aylmkklglsleealalvrsrrpgavpnpgqlrfLleye
0048076 (Phosphotyrosine protein) phosphatases II 60-194 1.2e-21 72.3 In-house 4-142 (145) alignment 
Range on Protein: 60-194
Range on HMM: 4-142/145.0
PLLVLPEkIYLYSEPTVKELL-----PFDVVINVAEEANDLRMQVPavEYHHYRWE--HDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLII
|  .||  .|| | ||...|       .  |.|.. | ..|  ..   .|... |.  .  ... .|...  .|..|  . ...|.||. |..|..||..
pseilpg.lylgslptaldlellkdlgittvlnltselellerlgi..qylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlva

AYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVAL
||.|.....|| . ..|..|.  ...|. | . .|.|.|  |
aylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_MKPLT_pd Subfamily MKPLT 61-192 4.5e-15 49.6 In-house 22-158 (164) alignment 
Range on Protein: 61-192
Range on HMM: 22-158/164.0
LLVLPEKIYLYS-----EPTVKELLPFDVVINVAEEANDLRMQvpAVEYHHYRWEHDS--QIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIA
 .||....||       . .| . |  . ..||..| .|   .  .|||   . |  |  |..  |  ..  .  |     ..|.||. | |||..  .|
svvledtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEV
...|..   |...|. || |   ..|  |.. || ..| 
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 61-192 4.5e-15 49.6 In-house 22-158 (164) alignment 
Range on Protein: 61-192
Range on HMM: 22-158/164.0
LLVLPEKIYLYS-----EPTVKELLPFDVVINVAEEANDLRMQvpAVEYHHYRWEHDS--QIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIA
 .||....||       . .| . |  . ..||..| .|   .  .|||   . |  |  |..  |  ..  .  |     ..|.||. | |||..  .|
svvledtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

YIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEV
...|..   |...|. || |   ..|  |.. || ..| 
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee
PTPc_motif_SM00404 63-191 1.3e-34 114.0 In-house 5-138 (140) alignment 
Range on Protein: 63-191
Range on HMM: 5-138/140.0
VLPEkIYLYSEPTVK-----ELLPFDVVINVAEEAN-------DLRMQVPaVEYhhyrwEHDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATL
.||. .||.|... .     . | ...||||.|| .         ..|.| ..      .. .... .|......|..|..|..|.|.|||.|.||||||
ilph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqip.ldd.....nekdklskyldkvldfienaekkggkvlVHCqaGvSRSatl

IIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWE
||||.|.|..|||...|...|.|...|.|......||.|.|
iiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
0041856 (Phosphotyrosine protein) phosphatases II 66-198 2.1e-22 75.0 In-house 24-176 (182) alignment 
Range on Protein: 66-198
Range on HMM: 24-176/182.0
EKIYLYSEPT--------------------VKELlPFDVVINVAEEANDLRMQVPAV-EYHHYRWEHDSQIAldLPSLTSIIHAATTKREKILIHCQCGL
...|| | |.                    .|||  . ...|..||  .      .. .|... |. ..     |..| ..|...  . ...|.|| .|.
anlylgslpatrfiatqgpllstvadflrmlkel.gittivnlteelywpellerlgiqylylpwpDhgvpd..ldelldfieevleeggpvlVHCsaGv

SRSATLIIAYIMKYHNLSLRHSYDLLKSRAD--KINPSIGLIFQLMEWEVALNAKT
.|..||..||.||....||.. ..|..||     |.|. . . ||...|. |. ||
gRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
DSPc Dual specificity phosphatase, catalytic domain 68-191 1.2e-37 123.7 Pfam-A 1-131 (133) alignment 
Range on Protein: 68-191
Range on HMM: 1-131/133.0
IYLYSEPTVK----ELLPFDVVINVAEEAN---------DLRMQVPaVEYhhyrwEHDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAY
.||.|..| .    | | ...||||..| .           ....| ||      |....|. .|......|..|..|..|.|.|||.|.||||||||||
lylgskstaslalleklgitlvinvtkevpnnnaikkseieylrip.ved.....etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaY

IMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWE
.||..||||.. |...|.|..||.|..|...||.|.|
lmktknlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 68-191 1.2e-37 123.7 In-house 1-131 (133) alignment 
Range on Protein: 68-191
Range on HMM: 1-131/133.0
IYLYSEPTVK----ELLPFDVVINVAEEAN---------DLRMQVPaVEYhhyrwEHDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAY
.||.|..| .    | | ...||||..| .           ....| ||      |....|. .|......|..|..|..|.|.|||.|.||||||||||
lylgskstaslalleklgitlvinvtkevpnnnaikkseieylrip.ved.....etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaY

IMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWE
.||..||||.. |...|.|..||.|..|...||.|.|
lmktknlslneAyefvkerrskispnagflrqLleye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 75-156 3.3e-06 21.3 In-house 151-233 (307) alignment 
Range on Protein: 75-156
Range on HMM: 151-233/307.0
TVKELLPFDVVINVAEEANDLRMQvpAVEYHHYRWEHDSQIALDLPSLTSI--IHAATTKREKILIHCQCGLSRSATLI-IAYIM
 .|.| | . .|||..   |   .  .   .|..||   .       ||.|  ..|   ... ...||  |. || |.. |....
gakklapdedlinvttlkvdwaqk..srtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvq
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 81-182 4e-06 17.1 Pfam-A 318-427 (451) alignment 
Range on Protein: 81-182
Range on HMM: 318-427/451.0
PFDVVINVAEEANDLRMQVPAVEYHHYRWEHD----SQIALDLPSLTSIIHAATTK--REKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKS--
 .|.||.. |.      .  . ...... |..     ..  .||.....|.. ...   .|||..|. |   |.....| . .|.... . .    ..  
evdlvislsekivsseteekkkkvlelklesskkgskeLrkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailclyfdeegklkkseeekki

RADKINPSIG
  . |   . 
nkelirkrla
0051082 (Phosphotyrosine protein) phosphatases II 82-190 5.1e-13 44.4 In-house 34-149 (151) alignment 
Range on Protein: 82-190
Range on HMM: 34-149/151.0
FDVVINVAEEA--NDLRMQVP--AVEYHHYRWEHDS--QIALDLPSLTSIIHAATTK-REKILIHCQCGLSRSATLIIAYIMKyHNLSLRHSYDLLKSRA
.....|. .|   . .   .|   .|..|. .. ..  .. | .... ......  |   ..|.||  |..|..||...|.|. ...||   .. .... 
iktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkr

D-KINPSIGLIFQLMEW
  ...|. . .|||...
pgvvqpnqqflfqlfal
subfamily_DSP6_pd Subfamily DSP6 83-196 4e-22 72.4 In-house 41-156 (158) alignment 
Range on Protein: 83-196
Range on HMM: 41-156/158.0
DVVINVAEEANDLRMQVPAVEYHHYRWE--HDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPS
  |.||... ..   . . ..| .   |  .  ..|  .|   . |  | .| .|.|.||  |.||| |...||.||...||| ..|||.|.|  .| | 
kyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPn

IGLIFQLMEWEVALNA
  .. ||...|  |. 
fnfmgqlldferslrl
subfamily_DSP10_pd Subfamily DSP10 83-197 2.9e-21 70.0 In-house 41-156 (159) alignment 
Range on Protein: 83-197
Range on HMM: 41-156/159.0
DVVINVAEEANDLRMQvPAVEYHHYRWEHDSQI--ALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPS
..|.||. .      .  |..|..   .  |..            |. |  | ...|.||| |.|||||..|||.||. ||||...|.. |..   | | 
tavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPn

IGLIFQLMEWEVALNAK
.. . ||.|.|  || .
LnfmGqLlefekelnks
0043147 (Phosphotyrosine protein) phosphatases II 83-194 1.8e-17 59.1 In-house 46-160 (172) alignment 
Range on Protein: 83-194
Range on HMM: 46-160/172.0
DVVINVAEEANDLRMQVPA-VEYHHYRWE-HDSQIALDLPSLTSIIHA--ATTKREKILIHCQCGLSRSATLIIAYIMKyHNLSLRHSYDLLKSRADKIN
....|. |. .|    ..  ..|... |. |. ...  |... ..|.   |  . ...|.||  |..|..||..||.|. ..||| . ..|....  .. 
thivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgav

PSIGLIFQLMEWEVAL
.. . . .|...|  |
qnpsqyrflyyfekll
subfamily_DSP14_pd Subfamily DSP14 84-202 3.6e-24 79.5 In-house 34-152 (157) alignment 
Range on Protein: 84-202
Range on HMM: 34-152/157.0
VVINVAEEANDlrMQVPAVEYHHYRW--EHDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSI
..|||. |...   ... .|. . .   ......|  .   .  |.....|  |.|.||  | ||||.| .||.|||..||||..| |.||.   |.| .
liinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNv

GLIFQLMEWEVALNAKTNVQA
|   ||...| .|..|. |. 
GFwkqlidyEkklkgkssvkm
subfamily_DSP1_pd Subfamily DSP1 84-198 8.9e-23 75.2 In-house 46-160 (163) alignment 
Range on Protein: 84-198
Range on HMM: 46-160/163.0
VVINVAEEANDLRMQVPAVEYHHYRWEHDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGL
 ..||..| ..   ..   .  . . ... .| | .      |.....|. |.||||| |.|||.||..||.|| ...||   .|. |.|   |.| .| 
ailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagF

IFQLMEWEVALNAKT
. ||...|  | ...
vlqLlnyekklllel
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 84-192 1e-19 64.5 In-house 37-145 (148) alignment 
Range on Protein: 84-192
Range on HMM: 37-145/148.0
VVINVAEEANDLRMQvpAVEYHHYRWEHDSQIAL--DLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSI
.|   .|  | |  .  ..|| | . . . . .|    ..... .. |  . ...|.|.| | |||. | ......... ||.. ..| ||.   ..|  
ivnatkerdnaldqr..gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnl

GLIFQLMEWEV
| . || |.| 
gfLkqLaeleq
subfamily_Slingshot_pd Subfamily Slingshot 84-201 2.5e-18 60.0 In-house 47-164 (169) alignment 
Range on Protein: 84-201
Range on HMM: 47-164/169.0
VVINVAEEANDLRMQvpAVEYHHYRW--EHDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSI
 ..||..| ..   .   .||.. |   |.....     .  . |..| .|  |.|.||. |.||||. .||| || ..||| .... .|.| . |.|  
yilnvtkeidnffpe..kfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnk

GLIFQLMEWEVALNAKTNVQ
|.. || |.|  |.|. . .
gflkqleeyeGileaskqrh
0045098 (Phosphotyrosine protein) phosphatases II 84-194 2.3e-17 58.8 In-house 91-271 (278) alignment 
Range on Protein: 84-194
Range on HMM: 91-271/278.0
VVINVAEEAND-----------------------------------------------LRMQVPAVEYHHY-RWEH----DSQIALDLPSLTSIIHAATT
|.....|.  .                                                  .   |...||  |.     .. |   . .|.  |..|  
vivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealk

--------------KREKILIHCQCGLSRSATLIIAYIMKYH---NLSLRHSYDLLKSRADK-INPSIGLIFQLMEWEVAL
              . ...|.||. |..|..||..||.|...   ...| . .. |.|.    . .. . . .|.|... |
llaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
0049260 (Phosphotyrosine protein) phosphatases II 84-191 1.7e-15 52.5 In-house 36-146 (152) alignment 
Range on Protein: 84-191
Range on HMM: 36-146/152.0
VVINVAEEANDLRMQVPA-VEYHHYRWEHDS--QIALDLPSLTSIIHA-ATTKREKILIHCQCGLSRSATLIIAYIMKyHNLSLRHSYDLLKSRADKINP
..... |.  . . ...   .|.|. |. ..  ...  |. |  .|.  |  | ...|.||  |..|..||..||.|. ...|| . ..|....  ...|
tivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpgavp

SIGLIFQLMEWE
. | ...|.|.|
npgqlrflyefe
subfamily_DSP15_pd Subfamily DSP15 85-198 4.2e-18 59.9 In-house 31-143 (151) alignment 
Range on Protein: 85-198
Range on HMM: 31-143/151.0
VINVAEEANDLRMQvpaVEYHHYRWEHDSQIALD--LPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIG
...| ..|. |. .   .||. .. .  ..  |.  .    ..||..  | |..|.||  |.|||.||..||.|   .|. | . . .| .    || .|
ilsvhdnakkllkd...ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfG

LIFQLMEWEVALNAKT
   ||.|.| .  .. 
fkrqlkeyektklkey
0051429 (Phosphotyrosine protein) phosphatases II 85-194 1.1e-10 37.2 In-house 49-224 (272) alignment 
Range on Protein: 85-194
Range on HMM: 49-224/272.0
VINVAEEA----NDLRMQVPAVEYHHYRWEHDSQIALD----------------------------------------------------LpsLTSIIHA
.... .|     ..  .  | ..|.|. .. ||                                                            | .....
ivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellel

ATTkREKILIHCQCGLSRSATLIIAYIMKyHNLS--------------LRHSYDLLKSRADKINPSIGLIFQLMEWEVAL
  .  ...|.||  | .|..|.. ....  ...|              |.. .. |...  ..... . . .|.|....|
lld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
subfamily_DSP23_pd Subfamily DSP23 88-163 8.4e-06 20.5 In-house 38-114 (148) alignment 
Range on Protein: 88-163
Range on HMM: 38-114/148.0
VAEEANDLRMQVPAVEYHHYRWEHDSQIALD-LPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSL
..||..     .|.. ... | .     ||. .  .  ... |  | | . .||  |  |. |..  |..| ..|. 
lteegrphveatpnltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaa
0042113 (Phosphotyrosine protein) phosphatases II 94-191 9e-15 50.2 In-house 133-239 (245) alignment 
Range on Protein: 94-191
Range on HMM: 133-239/245.0
DLRMQVPAVEYHHYRWEhDSQIALDLPSLTSIIHAATT-----KREKILIHCQCGLSRSATLIIAYIM-----KYHNLSLRHSYDLLKSRADKINPSIGL
    .   . ||.. |. | ... .| .| ...... .     . ...|.||  |..|..|.|.||.|     |....|| . .. |.|.  .. .. . 
gddesrevihyhylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsq

IFQLMEWE
. .|.|..
yrflyeal
0036282 (Phosphotyrosine protein) phosphatases II 97-193 5.4e-14 47.7 In-house 65-168 (174) alignment 
Range on Protein: 97-193
Range on HMM: 65-168/174.0
MQVPAVEYHHYRWEHDSQIALD-LPSLTSIIHAATTK--REKILIHCQCGLSRSATLIIAYIMKYHNL-SLRHSYDLLKSRA---DKINPSIGLIFQLME
.    ..|... |. ..   |. | .. .... |  .    ..|.||  |..|..||..||.|... | ||.. .||....     .. .. . . .| .
lerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy

WEVA
.|  
fekl
DSPc_SM00195 101-156 1.5e-06 23.1 In-house 160-218 (263) alignment 
Range on Protein: 101-156
Range on HMM: 160-218/263.0
AVEYHHYRWEHDsQIALDLPSLTSIIHAATTKRE----KILIHCQCGLSRSATLIIAYIM
.  |..  |..  ..  .  |......|......     |..||. |..|..|.. . |.
vtqyqyknWpdh.gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii
PTPc_SM00194 101-156 1.5e-06 23.1 In-house 160-218 (263) alignment 
Range on Protein: 101-156
Range on HMM: 160-218/263.0
AVEYHHYRWEHDsQIALDLPSLTSIIHAATTKRE----KILIHCQCGLSRSATLIIAYIM
.  |..  |..  ..  .  |......|......     |..||. |..|..|.. . |.
vtqyqyknWpdh.gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii
0045450 (Phosphotyrosine protein) phosphatases II 102-192 3.3e-16 55.4 In-house 198-301 (307) alignment 
Range on Protein: 102-192
Range on HMM: 198-301/307.0
VEYHHYRWEhDSQIALDLPSLTSIIHAATT------KREKILIHCQCGLSRSATLIIAYIMKYHN--------LSLRHSYDLLKSRADKINPSIGLIFQL
  .|...|  | ..  .. .| ..|... .      | ...|.||  |..|..|.|.||.|...         ..|.. ..||...  .. .. . . .|
thfhytgwp.dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

MEWEV
.|.. 
yeall
0043336 (Phosphotyrosine protein) phosphatases II 102-190 1.6e-12 43.0 In-house 176-272 (278) alignment 
Range on Protein: 102-190
Range on HMM: 176-272/278.0
VEYHHYRWEhDSQIALDLPSLTSIIHAATT----KREKILIHCQCGLSRSATLIIAYIM-----KYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEW
. ||.. |  | ..  .| .| ....|. .    . ...|.||  |..|..|.|..|..     |.....| . .. |...  .. ..   . .| |.
thyhylgwp.dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
Y_phosphatase Protein-tyrosine phosphatase 102-157 1.3e-06 23.4 Pfam-A 136-194 (235) alignment 
Range on Protein: 102-157
Range on HMM: 136-194/235.0
VEYHHYRWEhDSQIALDLPSLTSIIHAATTKR----EKILIHCQCGLSRSATLIIAYIMK
 ..|.  |. |...  .  ||...|..  ...    .....||  | .|..|.. . |. 
kqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
Y_phosphatase Protein-tyrosine phosphatase 102-157 1.3e-06 23.4 In-house 136-194 (235) alignment 
Range on Protein: 102-157
Range on HMM: 136-194/235.0
VEYHHYRWEhDSQIALDLPSLTSIIHAATTKR----EKILIHCQCGLSRSATLIIAYIMK
 ..|.  |. |...  .  ||...|..  ...    .....||  | .|..|.. . |. 
kqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill
0040439 (Phosphotyrosine protein) phosphatases II 103-191 2.9e-15 52.0 In-house 144-242 (249) alignment 
Range on Protein: 103-191
Range on HMM: 144-242/249.0
EYHHYRWEhDSQIALDLPSLTSIIHAATT------KREKILIHCQCGLSRSATLIIAYIM-----KYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWE
 .... |  | ..  ....| ..|.|. .      | ...|.||  |..|..|.|.||.|     |.....| . ..||.|.  .. .. . . .|.|..
hiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 103-193 2.6e-13 45.4 In-house 175-274 (317) alignment 
Range on Protein: 103-193
Range on HMM: 175-274/317.0
EYHHYRWEHDSQIALDLPSLTSIIHAATTK----REKILIHCQCGLSRSATLIIAYIM-----KYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVA
  .|| .  |  .  .. .| ....|. ..     ...|.||  |..|..|.|.||.|     |...... . .. |...  .. .. . . .|....  
thfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
0036941 (Phosphotyrosine protein) phosphatases II 103-199 7.1e-13 44.0 In-house 171-281 (297) alignment 
Range on Protein: 103-199
Range on HMM: 171-281/297.0
EYHHYRWEHDSQIALDLPSLTSIIHAATT------KREKILIHCQCGLSRSATLIIAYIM--------KYHNLSLRHSYDLLKSRADKINPSIGLIFQLM
 ..||    |  .  .  || ..|... .      . ...|.||  |..||.|.|.|..|        |......   .  |...   . .. .   .| 
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly

EWEVALNAKTN
|..  |  |..
eallellkkkl
0047943 (Phosphotyrosine protein) phosphatases II 103-170 3.1e-10 35.4 In-house 170-247 (273) alignment 
Range on Protein: 103-170
Range on HMM: 170-247/273.0
EYHHYRWEhDSQIALDLPSLTSIIHAATT------KREKILIHCQCGLSRSATLIIAYIM-----KYHNLSLRHSYDLL
 .|.. |  | ..  .| || ..|... .      . .....||  |..|..|.|.....     |......   . ||
hfhytgwp.dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkll
0046845 (Phosphotyrosine protein) phosphatases II 103-163 5.2e-09 31.4 In-house 169-242 (284) alignment 
Range on Protein: 103-163
Range on HMM: 169-242/284.0
EYHHYRWEhDSQIALDLPSLTSIIHAATTK------REKILIHCQCGLSRSATLIIAYIMKYH--------NLSL
 .|.  |  | ..  .. .| ...... .        ..|..||  |..|..|.|........        ....
hfhytswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdv
0051299 (Phosphotyrosine protein) phosphatases II 103-165 1e-08 30.5 In-house 186-256 (288) alignment 
Range on Protein: 103-165
Range on HMM: 186-256/288.0
EYHHYRWEhDSQIALDLPSLTSIIHAATTK----REKILIHCQCGLSRSATLIIAYIM-----KYHNLSLRH
 .|.. |  | ..  .. .| ...... ..       ...||  |..|..|.|.....     | . ... .
hfhytnwp.dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvle
PTPc_DSPc_SM00012 103-161 1e-07 27.4 In-house 4-67 (105) alignment 
Range on Protein: 103-161
Range on HMM: 4-67/105.0
EYHHYRWEHDsQIALDLPSLTSIIHAATTKRE------KILIHCQCGLSRSATLIIAYIMKYHNL
 ||.. | .  ..  .  |......|  ....       ...||. | .|..|.. ..|.  .. 
hyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqle
0039614 (Phosphotyrosine protein) phosphatases II 104-193 9.5e-15 50.3 In-house 188-287 (297) alignment 
Range on Protein: 104-193
Range on HMM: 188-287/297.0
YHHYRWEhDSQIALDLPSLTSIIHAATT------KREKILIHCQCGLSRSATLIIAYIM-----KYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEV
.... |  | ..  .| .| ...... .      | ...|.||  |..|..|.|.||.|     |...... . .. |...  .. .. . . .|.....
fqytgwp.dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall

A
 
e
0038934 (Phosphotyrosine protein) phosphatases II 104-181 5.8e-12 41.1 In-house 80-163 (194) alignment 
Range on Protein: 104-181
Range on HMM: 80-163/194.0
YHHYRWEH-DSQIALDLPSLTSIIHAATTKR-----EKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSI
......   |   . .|  |....... ..      .....||  ||.|..||..||.......|.. ...|....  .. |..
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnq
0050432 (Phosphotyrosine protein) phosphatases II 104-164 3.8e-08 28.5 In-house 202-268 (308) alignment 
Range on Protein: 104-164
Range on HMM: 202-268/308.0
YHHYRWEhDSQIALDLPSLTSIIHAATTK--REKILIHCQCGLSRSATLIIAYIM-----KYHNLSLR
.|.  |. | ..  .. .| ...... ..   ..|..||  |..|..|.|.....     | ..... 
fhytnWp.dhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvf
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 108-167 2.4e-07 23.5 In-house 42-100 (128) alignment 
Range on Protein: 108-167
Range on HMM: 42-100/128.0
RWEHDsQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSY
 |..| ..   ..    |. .       . .||.||  |.  .. .|.|||.  .|... 
dwsad.klpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkal
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 108-167 2.5e-07 23.5 In-house 41-99 (128) alignment 
Range on Protein: 108-167
Range on HMM: 41-99/128.0
RWEHDsQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSY
 |..| ..   ..    |. .       . .||.||  |.  .. .|.|||.  .|... 
dwsad.klpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkal
subfamily_DSP19_pd Subfamily DSP19 110-194 6e-18 59.6 In-house 66-150 (152) alignment 
Range on Protein: 110-194
Range on HMM: 66-150/152.0
EHDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVAL
. . ..   |.. .  |. | .|   .|.||. | ||||...|||.|| ..|||.....|...    |.|  | | || |.|  |
lpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP8_pd Subfamily DSP8 112-198 1.2e-20 67.7 In-house 72-158 (159) alignment 
Range on Protein: 112-198
Range on HMM: 72-158/159.0
DSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALNAKT
| ..   ... .. |  | ..  ..|.|.  | |||||..||||||. ..|| ..|  .|..   |.|..  . ||.|.|  |. .|
dekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkllt
subfamily_DSP12_pd Subfamily DSP12 116-206 1e-20 68.7 In-house 65-154 (155) alignment 
Range on Protein: 116-206
Range on HMM: 65-154/155.0
ALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALNAkTNVQANSYR
   |.. .. |. |  .....|.||| |.|||.|..|||.||...||| . ..|.|.   .|.|  | . ||  .|       . . ..|.
LshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck.vdtsnkayk
subfamily_STYX_pd Subfamily STYX 118-201 1.7e-15 50.5 In-house 81-164 (166) alignment 
Range on Protein: 118-201
Range on HMM: 81-164/166.0
DLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALNAKTNVQ
 ||   ..|  .  |  |.|.| ..|.||||.|.|||||. . |  |...  .. |   |||  |.. ||.|.|.   || ...
ylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakltik
subfamily_PTPDC1_pd Subfamily PTPDC1 120-196 1.8e-06 22.5 In-house 102-177 (182) alignment 
Range on Protein: 120-196
Range on HMM: 102-177/182.0
PSLTSIIHAATTKReKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALNA
  .  ... | ..  |. .||  || |   || .|..  ..|.  .. .|..|.  |   . . .  . |..  |  
Ldivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefalflip
0048567 (Phosphotyrosine protein) phosphatases II 122-171 1.3e-07 26.1 In-house 63-115 (157) alignment 
Range on Protein: 122-171
Range on HMM: 63-115/157.0
LTSIIHAATTKREKILIHCQCGL---SRSATLIIAYIMKYHNLSLRHSYDLLK
| ....  . .. .| .||  ||   .|.|||| .|........ .  ...|.
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplr
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 123-195 1.9e-09 30.8 In-house 70-142 (145) alignment 
Range on Protein: 123-195
Range on HMM: 70-142/145.0
TSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALN
| .|     .   ...||  |.||| |. .|..||| |..| ..   ..|.  .  | . .. .|.. |  | 
tdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlk
subfamily_PTPMT1_pd Subfamily PTPMT1 124-178 7.1e-11 36.8 In-house 98-152 (171) alignment 
Range on Protein: 124-178
Range on HMM: 98-152/171.0
SIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKIN
 .|.  ..| ... .||. | .|||||...|.|| ..||. .  . ||.. ..|.
efiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiir
subfamily_CDC14_pd Subfamily CDC14 124-162 8e-07 23.2 In-house 254-292 (328) alignment 
Range on Protein: 124-162
Range on HMM: 254-292/328.0
SIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLS
. ...| . . .| .||. || |  ||| .|.|| ....
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrft
subfamily_DSP3_pd Subfamily DSP3 125-196 9.6e-16 51.8 In-house 89-159 (162) alignment 
Range on Protein: 125-196
Range on HMM: 89-159/162.0
IIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRAdKINPSIGLIFQLMEWEVALNA
| .| ..|. |.|.||. |.||||||..||.| .....| .     ...  .| |  | . ||.| .  |. 
idealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkr
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 127-192 6.8e-16 52.0 In-house 83-150 (154) alignment 
Range on Protein: 127-192
Range on HMM: 83-150/154.0
HAAT--TKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEV
. |    ...|.|.|.. |.||||.|.|.|.|.  ..||  .. |||.   .|.|  |.. ||  .| 
ddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 132-195 2.4e-17 56.9 In-house 196-259 (263) alignment 
Range on Protein: 132-195
Range on HMM: 196-259/263.0
KREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALN
|.  .|.||. |.|||.||.|.|.||...| .....|| ...  .|.| .|.. ||. .|  | 
kkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf