Gene YVH1 in Saccharomyces cerevisiae

Synonym: YIR026C, YVH1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP036_AA protein Get Run
ScerP036_AA_9-175 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 4-169 5.5e-22 74.3 In-house 88-301 (307) alignment 
Range on Protein: 4-169
Range on HMM: 88-301/307.0
NANSVDEEVTRILGGIYLgGIRPIIDHRPLGA----------EFNITHILSVIKFQ--------------------------VIPEYLiRKGYTLKNIPI
||. |.  ....|.| .| . . |.   ||            | ..|.|... ..                           .. |.   .|||. ....
NAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlev

DDD-----------------DVTDVLQYFDETNRFIDQCLFPNEVeysprlvdfkkKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYG--------LSLSM
 |                    ..| ..|.|. .||....  .|             |. | |  || ||..|. |||.||||.|..        ..|  
tdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee...........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlle

AMHAVKRKKPSVEPNENFMEQLHLFEK
|.. .....| . .|......|. ...
avkllreqRpgavqnpeqyrflyeall
0051429 (Phosphotyrosine protein) phosphatases II 4-169 3.8e-15 51.7 In-house 8-222 (272) alignment 
Range on Protein: 4-169
Range on HMM: 8-222/272.0
NANSVDEEVTRILGG-IYLGGIR---PIIDHRPLgAEFNITHILSVIKFQ---VIPEYLIRKGYTLKNIPIDDDDVTDVLQYF-----------------
||. |.    ... | .|..|      . | . | .| .|..|... .       . ..   | .. ..|| ||.....|...                 
Nardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilr

-------------------------------DETNRFIDQCLFpneveysprlvdfkkkpqRGAVFAHCQAGLSRSVTFIVAYLMYrYGLS---------
                               ..  ......|                    |.|  || || .|. |.....|.. .|.|         
ellltlllsagearevmhlhytdwpdhgvpqeallellellld..................ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYl

-----LSMAMHAVKRKKPSVEPNENFMEQLHLFEK
     |  |.. .... | . ..| ....|. ...
ltnlyleeaveelraqrpgavqteeqylflyeall
subfamily_DSP6_pd Subfamily DSP6 7-170 7.7e-26 84.5 In-house 9-153 (158) alignment 
Range on Protein: 7-170
Range on HMM: 9-153/158.0
SVDEEVTRILGGIYLGGIRPIIDHRPLgAEFNITHILSVIKfQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkk
. .|   .||  .|||  .   .   | ....| ..| | . ..   .   .  . ..|||.|   ... ..| |. .|||.                  
aeaefpveilpllylGsakdasnlevl.kklkikyvlnvts.nlpnkfeesgelkylqipiedhlsqnlakffPeaiefidea.................

KPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
. .  .|. || ||.||||| ..|||| .. |||  | . ||..|... || |||.||  ||..
rskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_STYX_pd Subfamily STYX 7-169 5.3e-16 52.2 In-house 7-155 (166) alignment 
Range on Protein: 7-169
Range on HMM: 7-155/166.0
SVDEEVTRILGGIYLGGIRPIID-HRPLGAEFNITHILSVIkfQVIPEYLIR----KGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLfpneveysprl
|   |.  || |..||     .  . .   .  ||||. .   | |   ||.    . .    . . |. | ....|. ..  |||..|           
skrremqeilpglflgpysaamksklevlkkhgithivcir..qnieanlikpnfpdrfrylvldvadntveniirylptvkefiddsl...........

vdfKkkpQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
   .   . | |. | .||.||| ....||.|  |||    |.. |....  ..||| |..||. .| 
...q...kggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_DSP19_pd Subfamily DSP19 8-169 1.3e-27 91.0 In-house 8-148 (152) alignment 
Range on Protein: 8-169
Range on HMM: 8-148/152.0
VDEEVTRILGGIYLGGIRPIIDHRPLGaEFNITHILSVIkFQvIPEYlIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfKK-
 | ||. .   .||| .    |.. |  | .|||||.|   . .|.    | .| ..|.| |.. ||.|.|..|.  ||..                .. 
edlevgeveprlylgsqdvaadkeilk.ekkitHilnva.tg.vpnv.fpkdftylsieilDlpetdllsylkealdFieea...............rsk

KpqrGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
.   |||. ||.|| |||.....|||| .  |||. |.. |. ..|...||| |..||. .|.
d...gavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyea
subfamily_DSP8_pd Subfamily DSP8 9-169 1.7e-20 67.2 In-house 12-152 (159) alignment 
Range on Protein: 9-169
Range on HMM: 12-152/159.0
DEEVTRILGGIYLGGIRPIIDHRPLGaEFNITHILSVIKFQVIPEYLIRKGytLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKP
| ..||||  .|||  .  ...  |  . .|...| . .  . .| |  .   .  .|. |.   ..|..||..  |||..                 | 
dvgptrilknlylGsqkdvlseells.klgisyvlnasnscpkleelkesk..flrvPvkDkydekllpwfdksvefidka.................ks

QRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
. | |. |. || ||| | ..||.| .  .||  | . || |.|...|| ||..||  .||
engrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyek
0046846 (Phosphotyrosine protein) phosphatases II 10-170 2.2e-25 84.8 In-house 10-171 (176) alignment 
Range on Protein: 10-170
Range on HMM: 10-171/176.0
EEVTRILGGIYLGGiRP----------IIDHRPLGAEFNITHILSVIKF--------QVIPEYLIRKGYTLKNIPIDDDDVTDVlQYFDETNRFIDQCLf
. ...|.....||. ||          . |   .  | .||..... .           ....| . |.. ...|..| .| |  ....|  .||...| 
ldldyinanlilgs.rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal.

pneveysprlvdfkkkPQRGAVFAHCQAGLSRSVTFIVAYLMYR-YGLSLSMAMHAVKRKKP-SVEPNENFMEQLHLFEKM
                 . | |  ||.||..|. |...|||... .|||.  |.. |....|  . ........|. ||..
................keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
subfamily_DSP10_pd Subfamily DSP10 10-169 2.3e-24 80.1 In-house 12-151 (159) alignment 
Range on Protein: 10-169
Range on HMM: 12-151/159.0
EEVTRILGGIYLGGIRPIIDHRPLgAEFNITHILSVIkfQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfKKkpQ
 .....|  ..||  .   |.  |  ..|||..| |   . .| .   .. . | ||. |    .. |||.|   ||..                .|  .
apasqvlpfLflGsekdaadldal.drlnitavlnvt..tsvPnefeeealkYkripvsDtskqnlkqyfeealefieea...............rk..k

RGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
   |. |||||.|||.|...||||.. .|||. | . || |.| . || ||| ||  |||
gsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefek
subfamily_DSP3_pd Subfamily DSP3 10-167 7.3e-21 68.5 In-house 9-153 (162) alignment 
Range on Protein: 10-167
Range on HMM: 9-153/162.0
EEVTRILGGIYLGGIRPIIDHRPLgAEFNITHILSVIKF---QV--IPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLFPneveysprlvdf
.||  .  ..|.|.     |.. | ... |||.|   .    .|   .|.    . .   ...||   .|. .||... .|||. |              
kevdevypklyvgdeavakdkskL.kklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsq............

kkkpQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKpSVEPNENFMEQLHLF
    ..| |. ||..|.||| | ..|||| |  ..|  |...|..|. .. ||| |..||  .
....kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLael
subfamily_DSP12_pd Subfamily DSP12 11-184 3.6e-62 203.3 In-house 1-155 (155) alignment 
Range on Protein: 11-184
Range on HMM: 1-155/155.0
EVTRILGGIYLGGIRPIIDHrPLGAEFNITHILSVIKFQViPEYLIRKGYTL-KNIPIDDDDVTDVLQYFDETNRFIDQCLfpNEveysprlvdfkkkpq
||.|||.|.||||....... .| .|..|||.|||||... ||. ..||..  |.|.|.|.. .|.|...||...||...|  .|               
evsrilpglylggleavqee.ellkelkithvlsvikeel.pehklkkgkvstkfiqilDepeediLshldeavdFieeal..ee...............

RGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKMGGDfVDFDNPAYKQ
.|||..|||||.|||||...||||....|||..|...||.|||..||||.|.|||.||||||.. ||..|.|||.
egavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck.vdtsnkayke
0044763 (Phosphotyrosine protein) phosphatases II 11-170 3.6e-36 119.8 In-house 22-169 (178) alignment 
Range on Protein: 11-170
Range on HMM: 22-169/178.0
EVTRILGGIYLGGIRPiIDHRPLGAEFNITHILSVIKFQV------IPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLfpneveysprlvdf
 ...||.|.|||.  |  |...|  | .||||... . .       .|... . |.. ..|||.|..|.|.|..|.|. .||...|              
naseilpglylgslpp.addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal..............

kkKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPsVEPNENFMEQLHLFEKM
  ... |.|. ||.||..|| |...||||...||||  |.. |....| . ||.....||..||..
..dekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr
0036282 (Phosphotyrosine protein) phosphatases II 11-170 7.9e-28 92.7 In-house 11-168 (174) alignment 
Range on Protein: 11-170
Range on HMM: 11-168/174.0
EVTRILGGIYLGGIRPIidHRPLGAEFNITHILSVIKFQVIP------------EYLIRKGYTLKNIPIDDDDVTDVLQyFDETNRFIDQCLfpneveys
 ...|......|.      . ..  |..||....... .               |.| | |.... .|..|. | |. . ..|  .|....|        
dlsyitprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal........

prlvdfkKKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGL-SLSMAMHAVKRKK---PSVEPNENFMEQLHLFEKM
       .... | |  || ||..|. |...||||.|..| ||  |.. |....   | . ........|. |||.
.......sedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
subfamily_Slingshot_pd Subfamily Slingshot 11-170 2e-19 63.6 In-house 18-156 (169) alignment 
Range on Protein: 11-170
Range on HMM: 18-156/169.0
EVTRILGGIYLGGIRPIIDHRPLgAEFNITHILSVIKfqVIPEYLiRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKPQR
. ..|   .|||      .   |  | ....|| | |   | ..   . .. .|| . |.. ||.|.|..|| .||...                 | . 
saskifdhvylGsewnasnleel.kengveyilnvtk..eidnff.pekfeylnirvydeeetdllkywnetykfieka.................kkkg

GAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
  |. ||. |.||| . ..|| | .|||||  |.. ||...  ..||..|..||. .| .
skvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGi
subfamily_DSP1_pd Subfamily DSP1 11-89 3.6e-06 21.1 In-house 17-91 (163) alignment 
Range on Protein: 11-89
Range on HMM: 17-91/163.0
EVTRILGGIYLGGIRPIIDHRPLgAEFNITHILSVIKFqvIPEYLIRkGYTLKNIPIDDDDVTDVLQYFDETNRFIDQC
 |..||  .|||.     . . | .. .||.|| | |   ....     .. |.....|    |. ..|.|   |||..
PvekildfLylGsetvasnleiL.kslgitailnvske..ldnvfed.lfeYkklkleDspkadislvfeeviefidev
PTPc_motif_SM00404 12-170 1.2e-47 156.3 In-house 2-140 (140) alignment 
Range on Protein: 12-170
Range on HMM: 2-140/140.0
VTRILGGIYLGGIRPIIdHRPLGAEFNITHILSVIKFQVIPeyliR--KGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKPQ
..|||...|||... .. ...| ....|||...|.......    .  .|.....||.||........|.|....||...                 . .
psrilphlylgskskaq.npallkklgithvinvteevslt....kensgfqilqiplddnekdklskyldkvldfiena.................ekk

RGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
.|.|. |||||.|||.|.|.||||....|||..|...||...|...||.||..||. .||.
ggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
0041856 (Phosphotyrosine protein) phosphatases II 12-173 4.7e-31 103.2 In-house 19-174 (182) alignment 
Range on Protein: 12-173
Range on HMM: 19-174/182.0
VTRILGGIYLGGIRP-------------IIDHRPLGAEFNITHILSVIKFQVIPEYLIRKGYTLKNIPIDDDDVTDvlqyFDETNRFIDQCLFpneveys
 ..|. ..|||. ..             . |. ..  | .||.|...  ..  ||.| | |......|..|..|.|    .||...||...|        
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.......

prlvdfkkkpQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKP--SVEPNENFMEQLHLFEKMGGD
          . |.|. || ||..|. |...||||...|.||  |.. |....|   . || .|..|| |.|.. ..
..........eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_DSP15_pd Subfamily DSP15 12-170 9.9e-22 71.6 In-house 2-138 (151) alignment 
Range on Protein: 12-170
Range on HMM: 2-138/151.0
VTRILGGIYLGGIRPIIDHRPLGaEFNITHILSVIKfqviPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveyspRLvdfkkkpQRG
....| |.|||..|   |.  |. | ||||||||       .  ..|  . | |...|   ... ..|.|...|| .|          ||       . .
iskvlpglylgnfrdskdeelLk.eknithilsvhd....nakkllkdieYkciaasDtpsaklskffkesvefihkc..........Rl.......kee

AVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
.|. || ||.||||| .|||||    |.   |....| .. . .||  | .||. .||.
nvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
0048179 (Phosphotyrosine protein) phosphatases II 13-169 2.1e-30 100.7 In-house 5-142 (144) alignment 
Range on Protein: 13-169
Range on HMM: 5-142/144.0
TRILGGIYLGGIRPIIDhRPLGAEFNITHILSVIKfQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKPQRGA
..||.|.|||..   .|  .| ....||......  .  ||.|.| |... ..|..| .| | |....|. .||...                  .. | 
seilpglylgslptald.lellkklgittvinlte.eyepefleregiqylhlpwpDhgvpdllellleflefieea.................leeggp

VFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
|. ||.||..|. |...||||...||||  |.. |... | . ||......|...||
vlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 13-169 2.8e-30 100.3 In-house 5-140 (145) alignment 
Range on Protein: 13-169
Range on HMM: 5-140/145.0
TRILGGIYLGGIRPIIDhRPLGAEFNITHILSVikfQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLFPneveysprlvdfkkkpqRGA
..||.|.|||..   .| ..| ....||..|..      .|.| |.|... ..|..| .| | |....|  .||...|                    | 
seilpglylgslptald.lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealke.................ggp

VFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
|. ||.||..|. |...||||...|.||  |.. |... | . ||......|..||.
vlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefel
0051082 (Phosphotyrosine protein) phosphatases II 13-167 6.3e-21 70.0 In-house 9-149 (151) alignment 
Range on Protein: 13-167
Range on HMM: 9-149/151.0
TRILGGIYLGGIRpIIDHRPLGAEFNITHILSVIKFQ---VIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLFpneveysprlvdfkkkPQ
... ||.|..|     |. .| .| .|..|... . .     |||| . | ....|||.|...... ..||. ..|....|                 ..
syvtgglyrsggp.ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld................kk

RGAVFAHCQAGLSRSVTFIVAYLMYrYGLSLSMAMHAVKRKKP-SVEPNENFMEQLHLF
 | |. || ||..|. |....|||. .|.||  |.. ...| | .| ||. |. ||. .
ngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0037934 (Phosphotyrosine protein) phosphatases II 14-169 4.1e-22 74.3 In-house 41-239 (243) alignment 
Range on Protein: 14-169
Range on HMM: 41-239/243.0
RILGGIYLGGI---RPIID----HRPLGAEFNITHILSVIKFQ----------------------------------------VI--PEYLIRKGYTLKN
..........      . |    .  .  | .||.|... ...                                        .   ...| | .. .  
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IPIDD----DDVTDVLQYFDETNRFIDQCLFPNeveysprlvdfkKKPQRGAVFAHCQAGLSRSVTFIVAYLMYRY-GLSLSMAMHAVKRKKPS-VEPNE
.|. |    |...|.|...||.. ||...|  .            . .. | |  || ||..|. |.|.||||... |..|  |.. .....|  . ...
lpwpdhgvPdspedlldfldevrefieellsll............aldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtp

NFMEQLHLFEK
.....|. ...
sqyrflyeall
subfamily_LRR-DSP_pd Subfamily LRR-DSP 14-88 4.6e-08 26.5 In-house 122-193 (263) alignment 
Range on Protein: 14-88
Range on HMM: 122-193/263.0
RILGGIYLGGIRPIiDHRPLGAEFNITHI-LSVIKFQVIPEYLIrKGYTLKNipIDDDDVTDVLQYFDETNRFIDQ
 |. ...|||       ...  . ..||| |.| .|. .   |  | ... .  |.| |  |. |.|.||| ||..
eiidklflGgldsa.nnksilkdlgvthillavadfePlfPklf.kylsidd..iedvdeadisqhfeetnafiee
0036941 (Phosphotyrosine protein) phosphatases II 25-189 1.1e-20 69.6 In-house 79-294 (297) alignment 
Range on Protein: 25-189
Range on HMM: 79-294/297.0
RPIIDHRPLGA----------EFNITHILSVIKFQVI-------------PEYLIRKGYTLKNIPIDDDDVTDVLQY-------FDETNRFIDQCLFPNE
. |. . ||            | |.|.|... ..                .|.|  ...|.... .. .. .|. ..        ..  |.. .. ... 
kfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgw

VEYSP--------RLVDFKKK-----PQRGAVFAHCQAGLSRSVTFIVAYLM--------YRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKMGGD
 ....        ..... .|     |. | |  || ||..|| |||.|.||        ...|...  |.. .....| . ........|. .. .   
pdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk

FVDFDNPAYKQWKLKQ
..... |..|...| .
kkltkepllklvllll
0042113 (Phosphotyrosine protein) phosphatases II 26-169 2.4e-22 75.0 In-house 60-240 (245) alignment 
Range on Protein: 26-169
Range on HMM: 60-240/245.0
PIIDHRP----LGAEFNITHILSVIKFQVI-------------------------------------------PEYLIRKGYTLKNIPIDDDDVTDVLQY
|  .. .    .  | .||.|... ..                                              ...  |.....  .|..|..|.| |..
PlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllel

FDETNRFIDQCLFPneveysprlvdfkkkPQRGAVFAHCQAGLSRSVTFIVAYLM-----YRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
...  .|....|                 .. | |. || ||..|. |||.||||     ...|.||  |.. .....| . ........|. ...
lldflefvrkalae...............dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0049260 (Phosphotyrosine protein) phosphatases II 28-170 6.5e-25 83.0 In-house 23-148 (152) alignment 
Range on Protein: 28-170
Range on HMM: 23-148/152.0
IDHRPLGAEFNITHILSVIKFQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQ-CLFPNEveysprlvdfkkkpqrgAVFAHCQAGLSRSVT
 |.  .  | .||.|... ... ....   .... ...|..|. | |  |.... ..||.. .| ...                  |. || ||..|. |
adfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkgg.................pvlVHCsaGvgRtgt

FIVAYLMYrYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
...||||. .|.||  |.  |..|.| . ||......|. |||.
lvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl
0043147 (Phosphotyrosine protein) phosphatases II 30-170 3.6e-28 93.8 In-house 36-159 (172) alignment 
Range on Protein: 30-170
Range on HMM: 36-159/172.0
HRPLGAEFNITHILSVIKFQVIPEYLIRKGYTLKNIPIDDDDVTdVLQYFDETNRFIDQ--CLFPneveysprlvdfkkkpqRGAVFAHCQAGLSRSVTF
.. .  | .||||... .....||.| | |...  .|..| .|.  |....|. .|||.  .| |                  |.|  || ||..|..|.
fwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalsp.................ggpvlVHCsaGvgRtgtl

IVAYLMYrYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
..||||. .||||  |.. |..|.| . .|.... .|. |||.
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekl
DSPc Dual specificity phosphatase, catalytic domain 31-169 4.3e-26 86.3 Pfam-A 11-132 (133) alignment 
Range on Protein: 31-169
Range on HMM: 11-132/133.0
RPLGAEFNITHILSVIKFQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKPQRGAVFAHCQAGLSRSVTFIVA
 .| ....||....|.|    .     . ..  .||..|.. |.. ....|. .||...                 . ... |. |||||.||| |.|.|
lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka.................eqkgkkvlVHCqaGisRSatliia

YLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
|||....|||..|...||...... ||..|. ||  .|.
YlmktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 31-169 4.3e-26 86.3 In-house 11-132 (133) alignment 
Range on Protein: 31-169
Range on HMM: 11-132/133.0
RPLGAEFNITHILSVIKFQVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQClfpneveysprlvdfkkKPQRGAVFAHCQAGLSRSVTFIVA
 .| ....||....|.|    .     . ..  .||..|.. |.. ....|. .||...                 . ... |. |||||.||| |.|.|
lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka.................eqkgkkvlVHCqaGisRSatliia

YLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
|||....|||..|...||...... ||..|. ||  .|.
YlmktknlslneAyefvkerrskispnagflrqLleyer
0040439 (Phosphotyrosine protein) phosphatases II 35-170 1.2e-20 69.6 In-house 75-244 (249) alignment 
Range on Protein: 35-170
Range on HMM: 75-244/249.0
AEFNITHILSVIKFQ---------------------------------------------VIPEYLIRKGYTLKNIPiddddVTDVLQYFDETNRFIDQC
 | .||.|... ...                                               .| .  ...   ..|      ..| ..|... .||...
welgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.....dhgvppsfedlldfieav

LFPNEVEysprlvdfkkkPQRGAVFAHCQAGLSRSVTFIVAYLM-----YRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
.  .|             |. | |. || ||..|. |||.||||     ...|..|  |.. .....| . .|......|. ....
rkaleel...........pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 35-192 2.7e-20 68.3 In-house 107-296 (317) alignment 
Range on Protein: 35-192
Range on HMM: 107-296/317.0
AEFNITHILSVIKFQ------------------------VIPEYLIRKGYTLKNIPIDDD----------------DVTDVLQYFDETNRFIDQCLFPNe
 | ..|.|... ..                          . ..   .|.|| .... |.                .  .| ...|.  .|....   . 
weqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal.

veysprlvdfkkKPQRGAVFAHCQAGLSRSVTFIVAYLM-----YRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKMGGDFVDFDNPAYKQWKLKQ
            ... | |  || ||..|. |||.||||     ...|...  |.. .....| . ........|. .. .   ... . ||...... .
............edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkll

SIK
 ..
kll
0043336 (Phosphotyrosine protein) phosphatases II 35-168 6e-18 60.7 In-house 109-273 (278) alignment 
Range on Protein: 35-168
Range on HMM: 109-273/278.0
AEFNITHILSVIKFQ--------------------------------------------VIPEYLIRKGYTLKNIPidDDDVT-DVLQYFDETNRFIDQC
 | ..|.|... ..                                               .|...  .|  ...|  |..|  .. ...|  .......
welgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavreal

lfpneveysprlvdfkkKPQRGAVFAHCQAGLSRSVTFIVAYLM-----YRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFE
                 ... |.|  || ||..|. |||..||.     ...|..|  |.. .....|.  ........|. ..
.................edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0045098 (Phosphotyrosine protein) phosphatases II 36-169 1.3e-21 72.7 In-house 86-269 (278) alignment 
Range on Protein: 36-169
Range on HMM: 86-269/278.0
EFNITHILSVIKFQVI----------------------------------------------PEYLIRKGYTLKNI-PIDDDDVTDVL--QYFDETNRFI
| .||.|... ...                                                .|.|   | |  .. |..| .| .    ..|.|  .||
elgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefi

DQCLFPnevEYSPRLVDFKKKPQRGAVFAHCQAGLSRSVTFIVAYLMYRY---GLSLSMAMHAVKRKKPS-VEPNENFMEQLHLFEK
...|      .|  |. .   .. | |. ||.||..|. |...||||...   |..|  | . .....|  . .|......|. |. 
realkl...laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefll
0039614 (Phosphotyrosine protein) phosphatases II 36-170 1.1e-18 63.2 In-house 123-287 (297) alignment 
Range on Protein: 36-170
Range on HMM: 123-287/297.0
EFNITHILSVIKFQ----------------------VIPEYLIRKGYTLKNIPI-----------------DDDDVTDVLQYFDETNRFIDQCLFPNeve
| ..|.|... |.                          ..  ..|||. ....                  |..| . |....|  ......|  .   
eqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael...

ysprlvdfkkkPQRGAVFAHCQAGLSRSVTFIVAYLM-----YRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
           |. | |  || ||..|. |||.||||     ...|...  |.. .....| . ........|. ....
...........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 36-169 7.5e-15 48.6 In-house 26-150 (154) alignment 
Range on Protein: 36-169
Range on HMM: 26-150/154.0
EFNITHILSV-IKF-QVIPEY--LIRKGYTLK--NIPIDDDDVTDVLQYFDETNRFIDQCLfpNEVEysprlvdfkkkpqRGAVFAHCQAGLSRSVTFIV
. ||..|| | |    . ..    |  |. ..  |. . ||   |... .| .  |||. .    ||             .. |. |...|.||| ....
lkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddai..ggve.............nnkvlvhsdkGvsrsaalli

AYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
.||| .  .|||.|.  .|  .. ..||. |..||  |||
sylmdklkislslalellkdsryiikPnqGflkqleifek
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 36-169 2e-12 40.9 In-house 31-145 (148) alignment 
Range on Protein: 36-169
Range on HMM: 31-145/148.0
EFNITHILSVIKfqVIPEYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDqclfpneveysprlvdfKKKPQRGAVFAHCQAGLSRSVTFIVAYLMYR
....|.| .  |    .  |  .|    ....||..  |. ..|..   |..                 |.| . . |  |.| | |||    ...|.  
algvtrivnatk..erdnaldqrgieYlhvaldDkpkedlsaiFediiafvr.................kakdeGrrvLvhlqmGvsrssalallwlidf

YGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
   ||  |. .|| |.. |.||  |..||  .|.
krvslkealalvkskrryvdpnlgfLkqLaeleq
0049772 (Phosphotyrosine protein) phosphatases II 38-171 3e-27 91.6 In-house 162-273 (314) alignment 
Range on Protein: 38-171
Range on HMM: 162-273/314.0
NITHILsvikfQVI--PEYLIRKGYTLKNIPIDDdDVTDVLQYFDETNRFIDQClfPneveysprlvdfkkkpQRGAVFAHCQAGLSRSVTF-IVAYLMY
.. ..      ...  ||.. | |.....||..| . .. |..|||  .||...  .                . |.|. ||.|| .|. || ..||||.
dlellk.....eelydpelferlgikylripvpD.gsaplledfdeflefieea..d................kggpvlvHCkaGkgRtgtfvvaaylmk

RYGLSLSMAMHAVKRKKPsVEPNENFMEQLHLFEKMG
..|.||  |.. |..| | . ||..|.||| ..|.. 
llgvsleealedvrlkRp.inpnpgfieqleqyefil
0046845 (Phosphotyrosine protein) phosphatases II 43-166 7.4e-10 34.1 In-house 153-268 (284) alignment 
Range on Protein: 43-166
Range on HMM: 153-268/284.0
LSVIKFQVIPEYLIRKGYTLKNIPidDD----DVTDVLQYFDETNRFIDQclfpneveysprlvdfkkKPQRGAVFAHCQAGLSRSVTFIVAYLMYRY--
|.. . ..  |... . .  ...|  |.    ...|.|..... ......                   |. | .  || ||..|. |||...|....  
leltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellen..................lpgggpivVHCsaGvgRtGtfialdllleqle

------GLSLSMAMHAVKRKKPSVEPNENFMEQLHL
      |...  |.. .....|    ..  .. .. 
keglllgvdvleavkrlreqRpgmvqtleqyrfvye
0051299 (Phosphotyrosine protein) phosphatases II 52-165 3.6e-10 35.2 In-house 179-279 (288) alignment 
Range on Protein: 52-165
Range on HMM: 179-279/288.0
PEYLIRKGYTLKNIPidDDDVTDVLQYFDETNRFIDQCLFpneveysprlvdfkkkPQRGAVFAHCQAGLSRSVTFIVAYLM-----YRYGLSLSMAMHA
 |... . .  .|.|  |..| | .. . .  |.....|                 .. | |  || ||..|. |||...|.     ...|...  |.. 
gesrtvthfhytnwp..dhgvpdspellldflrlvrkala................sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkr

VKRKKPSVEPNENFMEQLH
.....| . .... .. ..
lreqRpgmvqtpeqyrfvy
0038934 (Phosphotyrosine protein) phosphatases II 53-170 2.2e-18 62.1 In-house 73-175 (194) alignment 
Range on Protein: 53-170
Range on HMM: 73-175/194.0
EYLIRKGYTLKNIPIDDDDVTDVLQYFDETNRFIDQCLFPNEveysprlvdfkkkpqRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKP
|.. . |..  ..|. || ..  |.  ..  ...|. |  ..                |.|  || |||.|. |...|||.||.|.|.  |.. ...|.|
eefekagieylklpfpddgtvPsleillrfldlvdeflnedp...............ggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRp

SVEPNENFMEQLHLFEKM
.. || ...|.|. . |.
gaipnqdyleallkryke
0050432 (Phosphotyrosine protein) phosphatases II 60-163 1.4e-09 33.2 In-house 202-290 (308) alignment 
Range on Protein: 60-163
Range on HMM: 202-290/308.0
YTLKNIPidDDDVTDVLQYFDETNRFIDQCLfPNeveysprlvdfkkkpqrGAVFAHCQAGLSRSVTFIVAYLM-----YRYGLSLSMAMHAVKRKKPSV
.  .| |  |..| . .. . .  ......| |.                 | .  || ||..|. |||...|.     . .|...  |.. .....| .
fhytnWp..dhgvPpspeilldflelvrksl.pg.................gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm

EPNENFMEQ
 .... .. 
vqtpeqylf
PTPc_DSPc_SM00012 60-135 9.4e-07 24.4 In-house 10-64 (105) alignment 
Range on Protein: 60-135
Range on HMM: 10-64/105.0
YTLKNIPIDDDDVTDVLQYFDETNRFIDQclfpneveysprlvdfkkkpqRGAVFAHCQAGLSRSVTFIVAYLMYR
.. ...| . |.....|..... .. ...                     .. |  ||.|| .|. ||........
wpdhgvPeesdsilellravkknknkses.....................skpvvVhCsaGvgRtgtfvaldillq
0047943 (Phosphotyrosine protein) phosphatases II 63-166 1.6e-11 39.7 In-house 172-266 (273) alignment 
Range on Protein: 63-166
Range on HMM: 172-266/273.0
KNIPIDDDDVTDVLQYFDETNRFIDQCLFpneveysprlvdfkKKPQRGAVFAHCQAGLSRSVTFIVAYLM-----YRYGLSLSMAMHAVKRKKPSVEPN
   .. |..| . |... |  ......|               . |. | |  || ||..|. |||...|.     ...|...  |.. .....| . ..
hytgwpdhgvppslesllefielvrkale..............alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqt

ENFMEQLHL
......|. 
peqyrflye
0048567 (Phosphotyrosine protein) phosphatases II 94-157 6.8e-08 27.0 In-house 38-124 (157) alignment 
Range on Protein: 94-157
Range on HMM: 38-124/157.0
EVEYSPR------------------LVDFKK--KPQRGAVFAHCQAGL---SRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPN
.. | .                   | .| |  . ...|.  || |||   .|..|.| .||....|.. . |.. ..   |.  | 
glvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpf
subfamily_STYXL1_pd Subfamily STYXL1 103-170 2.2e-14 46.9 In-house 86-152 (157) alignment 
Range on Protein: 103-170
Range on HMM: 86-152/157.0
DFKKKpQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
.  || .  .|.   . |.|||.. |.||||| . ..|  |.. .|. |. |.|| .|.|||. .||.
ekhkk.egevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
subfamily_RNGTT_pd Subfamily RNGTT 103-164 4.9e-06 20.3 In-house 106-167 (189) alignment 
Range on Protein: 103-164
Range on HMM: 106-167/189.0
DFKKKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQL
.| ||  .  .  ||. |  |.  .||.||. .   |.. |... .. .|    .|.....|
effkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkel
PTEN_1 105-170 3.5e-17 57.9 In-house 125-190 (196) alignment 
Range on Protein: 105-170
Range on HMM: 125-190/196.0
KKKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
...|....|  ||.|||.||.| . |||||...|.   |.  |..| | . ||  ..|.|  ....
lsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 105-169 8.5e-13 41.6 In-house 75-139 (145) alignment 
Range on Protein: 105-169
Range on HMM: 75-139/145.0
KKKPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
| | .   || || ||.|||||  ||.||   ...|| |   |. ..    || .|. .|  .||
kgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlek
subfamily_DSP1_pd Subfamily DSP1 107-169 4.5e-17 56.6 In-house 92-154 (163) alignment 
Range on Protein: 107-169
Range on HMM: 92-154/163.0
KPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
| ..| |. |||||.||| |...|||| .  .||. |.. ||.... ..|| .|. ||  .||
kkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyek
subfamily_PTPMT1_pd Subfamily PTPMT1 107-169 1.6e-11 39.0 In-house 104-166 (171) alignment 
Range on Protein: 107-169
Range on HMM: 104-166/171.0
KPQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
. .   |. ||.|| .|| | . .|||... ||.  |..|.|.|.. .. ... ...|. .|.
askgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee
subfamily_MSG5_pd Subfamily MSG5 108-168 4.3e-12 39.4 In-house 97-157 (165) alignment 
Range on Protein: 108-168
Range on HMM: 97-157/165.0
PQRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFE
 .|  .. ||| ||||| ..||||.|  |.|||  | . .| .   ..|.  .. ||  .|
skrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewe
subfamily_DSP14_pd Subfamily DSP14 109-169 2.2e-16 54.2 In-house 82-142 (157) alignment 
Range on Protein: 109-169
Range on HMM: 82-142/157.0
QRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
. |..  || || ||| .. .||||    |||  | ..|| ..| ..||  | .||  .||
kggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEk
subfamily_LRR-DSP_pd Subfamily LRR-DSP 109-169 4.1e-15 49.6 In-house 196-256 (263) alignment 
Range on Protein: 109-169
Range on HMM: 196-256/263.0
QRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEK
..| |. ||.||.||| | ...||| .  | .  |.  |..|.| . ||  |..||  .||
kkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
subfamily_PTPDC1_pd Subfamily PTPDC1 109-167 9e-08 26.8 In-house 113-171 (182) alignment 
Range on Protein: 109-167
Range on HMM: 113-171/182.0
QRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLF
|.|.|  || ||| |    | .||.|   |. . |.. |. |.|.     . .| .. |
qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkef
subfamily_CDC14_pd Subfamily CDC14 109-160 1.6e-07 25.5 In-house 262-315 (328) alignment 
Range on Protein: 109-160
Range on HMM: 262-315/328.0
QRGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPS--VEPNENF
 .||.  ||.||| |  |.| .|||..|... . |.  ..  .|   . | ..|
aeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkf
subfamily_MKPLT_pd Subfamily MKPLT 110-170 1.5e-11 38.1 In-house 99-159 (164) alignment 
Range on Protein: 110-170
Range on HMM: 99-159/164.0
RGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
 | |. ||. | ||| .  ||.|.   |  |  | . .| ..  | ||  |. ||  ||..
GGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 110-170 1.5e-11 38.1 In-house 99-159 (164) alignment 
Range on Protein: 110-170
Range on HMM: 99-159/164.0
RGAVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVEPNENFMEQLHLFEKM
 | |. ||. | ||| .  ||.|.   |  |  | . .| ..  | ||  |. ||  ||..
GGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_Laforin_pd Subfamily Laforin 112-155 8.6e-06 18.7 In-house 112-155 (183) alignment 
Range on Protein: 112-155
Range on HMM: 112-155/183.0
AVFAHCQAGLSRSVTFIVAYLMYRYGLSLSMAMHAVKRKKPSVE
 |. ||.||. || . .. .|.|  | ||.   . .  |.| | 
ivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvy