Gene MSG5 in Saccharomyces cerevisiae

Synonym: YNL053W, MSG5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily MSG5
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP056_AA protein Get Run
ScerP056_AA_231-377 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MSG5_pd Subfamily MSG5 211-377 2.4e-96 313.5 In-house 2-164 (165) alignment 
Range on Protein: 211-377
Range on HMM: 2-164/165.0
EDSDLNIDMVHAEIYQ-RTVYLDGPLLVLPPNLYLYSEPKLEDILSFDLVINVAKEIPNLEFLIPPemahkIKYYHIEWTHTSKIVKDLSRLTRIIHTAH
| ....|..|||||.. |.|||||||||||..|||||||||...|||||||||||||..||.|.|.     .|||||||.|.|||||||||||||||.|.
espnedielvhaeildvrrvyldgpllvlpeklylysepklkellsfdlvinvakeindlellvpa.....vkyyhiewehdskivkdlsrltriihaat

SQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSKNS
|..||||||||||.||||||||||||.||.|||.|||.|||.||.||||..|||||||||...|||.|
skrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskks
PTEN_1 215-361 1.5e-14 49.2 In-house 20-179 (196) alignment 
Range on Protein: 215-361
Range on HMM: 20-179/196.0
LNIDMVHAEIYQRTVYLDGPLLV-LPPNLYLYSEPKLEDIL------SFDLVINVAKEIPNLEFLIPPE--MAHKIKYYHIEWT--HTSKIVKDLSRLTR
|.. ... .|   ..  . |||  ....||. |.. ... |      .. ||.|.. | .. ..  ..|  ......|.|....  ... . . .  . .
ldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicks

IIHTAH--SQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMG
.|. .   ..|...||||. |..||. .. || |....|. ..|   ..     ..||..
fiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnsp
0037934 (Phosphotyrosine protein) phosphatases II 226-369 8.6e-18 60.2 In-house 30-237 (243) alignment 
Range on Protein: 226-369
Range on HMM: 30-237/243.0
QRTVYLDGPLLVLPPNLYLYSEPKLEDILS-------------FDLVINVAKEI----PN-------------------------------LEFL---IP
. . |... |   .|.|.. . |  | . .             .. .... ...     .                               |.     ..
egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldld

PEMAHKIKYYHIEWTH------TSKIVKDLSRLTRIIHT-----AHSQGKKILVHCQCGVSRSASLIVAYIMRYY-GLSLNDAYNKLKGVAKD-ISPNMG
..  . |.|... | .      .. ... |. .. .|.      | ..|...||||  ||.|.. ||.||.| .. |..| .|...|.      . .. .
dltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtps

LIFQLMEW
 . .|.|.
qyrflyea
0046846 (Phosphotyrosine protein) phosphatases II 228-374 5.9e-21 70.5 In-house 5-173 (176) alignment 
Range on Protein: 228-374
Range on HMM: 5-173/176.0
TVYLDGPLLVLPPNLYLYSEP---------KLEDIL------SFDLVINVAKEIP----NLEFLIPPEMAHKIKYYHIEWT--HTSKIvKDLSRLTRIIH
  .||..|  ...||.| | |          |.| |       ...|.|. .|.     ..  . | .....|.|.|. |   ..  . ..| .| ..|.
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

TAHSQGKKILVHCQCGVSRSASLIVAYIMRY-YGLSLNDAYNKLKGVAK-DISPNMGLIFQLMEWGTMLS
.| ..|...||||. |..|.. |..||.... .|||...|. ... .    . .... . .|.|.  .| 
ealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0044763 (Phosphotyrosine protein) phosphatases II 230-377 1.1e-29 98.8 In-house 18-174 (178) alignment 
Range on Protein: 230-377
Range on HMM: 18-174/178.0
YLDGPLLVLPPNLYLYSEPKLEDIL-----SFDLVINVAKEIPNLEFLIPPEMAHK--IKYYHIEW--THTSKIVKDLSRLTRIIHTAH-SQGKKILVHC
.   ..    |.||| | |  .|.       .....|...|...  .  .|.   .  |.|.|| .   ..  . . . .....|..|. ..|...||||
sdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHC

QCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKdISPNMGLIFQLMEWGTMLSKNS
..||.||..|..||.|...||||..|.. .. .   |.||.| . ||.|.  .| |.|
saGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkes
0041856 (Phosphotyrosine protein) phosphatases II 234-376 1.7e-23 78.6 In-house 18-175 (182) alignment 
Range on Protein: 234-376
Range on HMM: 18-175/182.0
PLLVLPPNLYLYSEPKLEDIL-------------------SFDLVINVAkeipnlEFLIPPE--MAHKIKYYHIEWTHTSKIVkdLSRLTRIIHTAHSQG
.|    .|||| | |  . |.                    . ...|..      |.| .||  . . |.|... |   .     |. | ..|......|
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd..ldelldfieevleeg

KKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAK--DISPNMGLIFQLMEWGTMLSKN
...|||| .||.|...|..||.|...|.|| .|.. ..       |.||.. . ||...  .| |.
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_DSP1_pd Subfamily DSP1 234-374 3.4e-22 73.3 In-house 17-157 (163) alignment 
Range on Protein: 234-374
Range on HMM: 17-157/163.0
PLLVLPPNLYLYSEPKLED--I---LSFDLVINVAKEIPNLeFliPPemAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSAS
|   . . ||| || .  .  |   |    ..||.||..|  |  .    .. |  ..| ...  | . ...    |....... |.|.||| |.|||..
PvekildfLylGsetvasnleiLkslgitailnvskeldnv.f..ed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsst

LIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLS
|..||.|.   .||..|..  | . . ||||.| . ||... . | 
lclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_STYXL1_pd Subfamily STYXL1 234-375 6.4e-19 61.7 In-house 11-155 (157) alignment 
Range on Protein: 234-375
Range on HMM: 11-155/157.0
PLLVLPPNLYLYS-----EPKLEDILSFDLVINVAKEIPNLEFLIpPEmAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSAS
|  ||| .|||       .|...  |    ..||...  .|   . .. . |.   ..| .  ..... |... . |.. . .|. .||  . |.||||.
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagv.ad.vakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaa

LIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSK
.|.||.| .. ..|..||..||   ... || ... || ||  .|..
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllg
0042113 (Phosphotyrosine protein) phosphatases II 238-369 1.2e-15 53.1 In-house 50-238 (245) alignment 
Range on Protein: 238-369
Range on HMM: 50-238/245.0
LPPNLYLYSEPKLEDIL---------SFDLVINVAKEIPN---------------------------------------LEFLIPPEMAHKIKYYHIEWT
 .|.... . |  |..              .... .| ..                                       .. |  .|  . | |... | 
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

HTSKI--VKDLSRLTRIIHTAHS--QGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEW
. .    ...| .. .....| .  .....||||  ||.|.. .|.||.|     ...|.|| .|. .|.     . .. . . .|.|.
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0048179 (Phosphotyrosine protein) phosphatases II 239-372 3.6e-25 83.8 In-house 8-143 (144) alignment 
Range on Protein: 239-372
Range on HMM: 8-143/144.0
PPNLYLYSEPKLEDILS-----FDLVINVAKEIPNLEFLIPpemahKIKYYHIEWT--HTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIV
 |.||| | | ..|.       ...|||.. | .. ..  .      |.|.|. |   ..  . ..| .. ..|..|...|...||||..||.|...|..
lpglylgslptaldlellkklgittvinlteeyepeflere.....giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTM
||.|...||||..|.. ..     . ||.| . .|.|....
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
PTPc_motif_SM00404 240-371 2.7e-37 122.8 In-house 7-139 (140) alignment 
Range on Protein: 240-371
Range on HMM: 7-139/140.0
PNLYLYSEPKLE-----DILSFDLVINVAKEIPNLeflippEMAHKIKYYHIE--WTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVA
|.|||.|..| .     . |....||||..|...       .   .... .|.   ....|..|.|......|..|...|.|.|||||.||||||.||.|
phlylgskskaqnpallkklgithvinvteevslt......kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGT
|.|||..|||..||. .|  .. ||||.....||.|. .
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0048076 (Phosphotyrosine protein) phosphatases II 240-372 1.1e-24 82.1 In-house 9-141 (145) alignment 
Range on Protein: 240-372
Range on HMM: 9-141/145.0
PNLYLYSEPKLEDILS-----FDLVINVAKEIPNLEflippemAHKIKYYHIEW--THTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVA
|.||| | |  .|.       . .|.|.. |...||       .. |.|... |   ..  . ..| .. ..|..|...|...||||. ||.|...|..|
pglylgslptaldlellkdlgittvlnltselelle.......rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTM
|.|...|.|| .|.....     . ||.| . .|.|. ..
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
DSPc Dual specificity phosphatase, catalytic domain 242-371 1.3e-39 130.1 Pfam-A 1-132 (133) alignment 
Range on Protein: 242-371
Range on HMM: 1-132/133.0
LYLYSEPKLE----DILSFDLVINVAKEIPNLeFLIPPEMAHKIKYYhIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRY
|||.|... .    ..|...|||||.||.||  ..| ..  .....  .| ....||.|.|......|..|...|||.|||||.|.||||.||.||.|..
lylgskstaslalleklgitlvinvtkevpnn.naikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

YGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGT
..||||.||. .|  .. ||||.|...||.|. .
knlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 242-371 1.3e-39 130.1 In-house 1-132 (133) alignment 
Range on Protein: 242-371
Range on HMM: 1-132/133.0
LYLYSEPKLE----DILSFDLVINVAKEIPNLeFLIPPEMAHKIKYYhIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRY
|||.|... .    ..|...|||||.||.||  ..| ..  .....  .| ....||.|.|......|..|...|||.|||||.|.||||.||.||.|..
lylgskstaslalleklgitlvinvtkevpnn.naikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

YGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGT
..||||.||. .|  .. ||||.|...||.|. .
knlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP10_pd Subfamily DSP10 252-376 1.1e-25 84.3 In-house 31-156 (159) alignment 
Range on Protein: 252-376
Range on HMM: 31-156/159.0
D-----ILSFDLVINVAKEIPNLEflippEMaHKIKYYHIE--WTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLND
|      |. . |.||....||       |  ...|| .|.   |.. .. .        |. |...|...||||| |.||||....||.|.. .|||||
dldaldrlnitavlnvttsvPnef.....ee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslnd

AYNKLKGVAKDISPNMGLIFQLMEWGTMLSKN
||.  |     ||||.. . ||.|.   |.|.
aykfvkekrpiisPnLnfmGqLlefekelnks
0045098 (Phosphotyrosine protein) phosphatases II 253-370 4.2e-20 67.7 In-house 128-268 (278) alignment 
Range on Protein: 253-370
Range on HMM: 128-268/278.0
ILSFDLVINVAKEIPNLEFLIPPEMAHKIKYYHI-EW----THTSKIVKDLSRLTRIIHTAHS--------------QGKKILVHCQCGVSRSASLIVAY
.  .| .. .  .. || .  .  . ......|.  |    .... |.| . .|.. |. |..              .|...||||. ||.|.. |..||
eevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaay

IMRYY---GLSLNDAYNKLKGVAKD-ISPNMGLIFQLMEWG
.|...   |..| .|...|.      . .|.. . .|.|. 
lmlelleggvdlleavkelrsqRpglavqnleqyrflyefl
subfamily_DSP6_pd Subfamily DSP6 254-375 2.3e-23 76.4 In-house 38-156 (158) alignment 
Range on Protein: 254-375
Range on HMM: 38-156/158.0
LSFDLVINVAKEIPNLeFlippEMAHKIKYYHIEW--THTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKG
|.   |.||....||  |    | ....||..|     .. .. | .    . |  |.|. .|.||||  |.|||  ...||.|... |||||||. .| 
lkikyvlnvtsnlpnk.f....eesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkk

VAKDISPNMGLIFQLMEWGTMLSK
   .||||. .. ||...  .|. 
rksnisPnfnfmgqlldferslrl
subfamily_DSP8_pd Subfamily DSP8 255-375 1.6e-20 67.3 In-house 40-156 (159) alignment 
Range on Protein: 255-375
Range on HMM: 40-156/159.0
SFDLVINVAKEIPNLEFLIPPEmAHKIkyyHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAK
  . |.|. .. |.||.|   .  ...    .. ... |..  . . .  |  |.|. ...|||.  | ||||....||||..  .||..||. .|   .
gisyvlnasnscpkleelkesk.flrv...PvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrp

DISPNMGLIFQLMEWGTMLSK
 ||||.  . ||.|.   | .
tispnlnflgqLleyekelkl
0051082 (Phosphotyrosine protein) phosphatases II 255-368 2.4e-13 45.5 In-house 33-148 (151) alignment 
Range on Protein: 255-368
Range on HMM: 33-148/151.0
SFDLVINVAKEIPNLeFLIP--PEMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQ-GKKILVHCQCGVSRSASLIVAYIMRyYGLSLNDAYNKLKG
 .. ..|. .| ..  ..    ||. .......|. ... ..   .  . .... . .. ....||||  |..|.. |...|.|  .|.||..|.. .. 
giktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrl

VAK-DISPNMGLIFQLME
     . ||.. .|||..
krpgvvqpnqqflfqlfa
subfamily_Slingshot_pd Subfamily Slingshot 257-374 2.1e-21 70.1 In-house 46-158 (169) alignment 
Range on Protein: 257-374
Range on HMM: 46-158/169.0
DLVINVAKEIPNleFlippeMAHKIKYYHIEW--THTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAK
. ..||.||| |  |      ..|..|..|    .......|   .  . |..|...| |.||||. ||||||| ..|| |. |||||..|.. .|   .
eyilnvtkeidn..f.....fpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrs

DISPNMGLIFQLMEWGTMLS
 | || |.. || |.  .|.
vikPnkgflkqleeyeGile
0043147 (Phosphotyrosine protein) phosphatases II 257-373 1.2e-18 62.9 In-house 46-160 (172) alignment 
Range on Protein: 257-373
Range on HMM: 46-160/172.0
DLVINVAKEipnlEFLIPPEMAHKIKYYHIEWT-HTSKIVKDLSRLTRIIHT--AHSQGKKILVHCQCGVSRSASLIVAYIMRyYGLSLNDAYNKLKGVA
....|. ..    . . .... . |.|... |  |.  . . | .. ..|..  | |.|...||||  ||.|.. |..||.|. .|||| .|.. ..   
thivnltel....lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekR

KDISPNMGLIFQLMEWGTML
  ...| . . .|...  .|
pgavqnpsqyrflyyfekll
0036282 (Phosphotyrosine protein) phosphatases II 257-374 2e-15 52.4 In-house 38-170 (174) alignment 
Range on Protein: 257-374
Range on HMM: 38-170/174.0
DLVINVAKEIPNLEFLI--------PPEMAHKIKYYHIEWT--HTSKIVKdLSRLTRIIHTAHSQ--GKKILVHCQCGVSRSASLIVAYIMRYYGL-SLN
  |... .|...  ...          .  . |.|... |   ..  . . | .. .....|.|.  |...||||  ||.|.. |..||.| ...| || 
ttvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslv

DAYNKLKGVA---KDISPNMGLIFQLMEWGTMLS
||.. .. .      . .... . .| ... .||
daldlvrelRlqrpgmvqtpsQyrflyyfeklls
subfamily_DSP14_pd Subfamily DSP14 258-377 1.8e-23 77.2 In-house 34-148 (157) alignment 
Range on Protein: 258-377
Range on HMM: 34-148/157.0
LVINVAKEIPNLEFlippEMAHKIKYyHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDIS
|.|||. |.|| ..    .  ...|   .| ....|..| . . .  |.... .| |.||||  |||||||| .||.|.|  |||..||. .| .   |.
liinvtvelpntkl....kdiervkv.pveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiir

PNMGLIFQLMEWGTMLSKNS
||.|   ||... . | ..|
PNvGFwkqlidyEkklkgks
0049260 (Phosphotyrosine protein) phosphatases II 258-373 8.6e-17 56.7 In-house 36-149 (152) alignment 
Range on Protein: 258-373
Range on HMM: 36-149/152.0
LVINVAKEIPNLEFLIPPEMahkiKYYHIEW--THTSKIVKDLSRLTRIIHT-AHSQGKKILVHCQCGVSRSASLIVAYIMRyYGLSLNDAYNKLKGVAK
 .... .. .. ..  .  .    .|.|. |   .. ..   |  | ..|.  |...|...||||  ||.|.. |..||.|. .|.|| .|.. ..   .
tivmltellelgklkceqyi....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRp

DISPNMGLIFQLMEWGTML
 . || | ...|.|. ..|
gavpnpgqlrflyefekll
subfamily_DSP19_pd Subfamily DSP19 259-371 6.8e-21 69.2 In-house 41-148 (152) alignment 
Range on Protein: 259-371
Range on HMM: 41-148/152.0
VINVAKEIPNLeFlippemAHKI--KYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDI
..||| ..||. |      ....  .  .|  .   .... |.. .  |. |.|.   .||||. |||||||...||.|.   |||..|..... . . |
ilnvatgvpnv.f......pkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpci

SPNMGLIFQLMEWGT
.|| | | || |. .
kPneGFikqLkeyea
subfamily_STYX_pd Subfamily STYX 272-372 6.3e-17 55.2 In-house 54-156 (166) alignment 
Range on Protein: 272-372
Range on HMM: 54-156/166.0
LIPPEMAHKIKYYHIE--WTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEW
|| |.. ....|  ..   . . .|.. | .   .| .. ..| |.||| ..|.||||.|..||||  |||   .|.  ..     |.|| |.. ||.|.
likpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkey

GTM
 ..
eai
0040439 (Phosphotyrosine protein) phosphatases II 273-369 6.4e-16 54.2 In-house 135-241 (249) alignment 
Range on Protein: 273-369
Range on HMM: 135-241/249.0
IPPEMAHKIKYYHIEWThTSKIVKDLSRLTRIIHTAHS------QGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKLKGVAKDISPNMG
  .|  .   .... |    .. .... | ..|. ...      .|...||||  ||.|.. .|.||.|     ...|..| .|...|.     . .| .
ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpe

LIFQLMEW
 . .|.|.
qyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 273-366 1.9e-12 42.7 In-house 168-269 (278) alignment 
Range on Protein: 273-366
Range on HMM: 168-269/278.0
IPPEMAHKIKYYHIEWTHTSKIVkDLSRLTRIIHTAHS----QGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKLKGVAKDISPNMGLI
  .|  .   |... | . .    .|| | ........    .....||||  ||.|.. .|..|..     ...|..| .|...|.     . ..   .
gdgesrtvthyhylgwpdhgvpe.slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy

FQL
 .|
rfl
subfamily_DSP12_pd Subfamily DSP12 274-375 3.5e-24 80.0 In-house 45-145 (155) alignment 
Range on Protein: 274-375
Range on HMM: 45-145/155.0
PPEMAHkIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTML
 .   .  |. .|  . .  |.. | . .. |. | ......||||| |||||.....||.|....|||..|....| . ..|.|| | . ||  .  | 
kkgkvs.tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg

SK
 |
ck
0049772 (Phosphotyrosine protein) phosphatases II 274-373 5.2e-24 80.9 In-house 173-273 (314) alignment 
Range on Protein: 274-373
Range on HMM: 173-273/314.0
PPEMAHK-IKYYHIEWTH-TSKIVKDLSRLTRIIHTAhSQGKKILVHCQCGVSRSAS-LIVAYIMRYYGLSLNDAYNKLKGVAKdISPNMGLIFQLMEWG
|.   .  |||..| ..  .  . .|. .. ..|..| ..|...||||. |..|... ...||.|...|.||..|.. ..     |.||.|.| ||... 
pelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqye

TML
 .|
fil
0038934 (Phosphotyrosine protein) phosphatases II 275-369 3.4e-14 48.4 In-house 72-172 (194) alignment 
Range on Protein: 275-369
Range on HMM: 72-172/194.0
PEMAHK--IKYYHIEWTH--TSKIVKDLSRLTRIIHT--AHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLME
||  .|  |.|... .    |.   . | |  .....  . ..|....|||  |..|.. |..||.. ..|.|...|.. .. . ... || . . .|..
peefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk

W
.
r
DSPc_SM00195 276-335 2.1e-06 22.7 In-house 155-218 (263) alignment 
Range on Protein: 276-335
Range on HMM: 155-218/263.0
EMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGK----KILVHCQCGVSRSASLIVAYIM
| ..|.. |...    ... .. . ........... .     |.|||. ||.|....... |.
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii
PTPc_SM00194 276-335 2.1e-06 22.7 In-house 155-218 (263) alignment 
Range on Protein: 276-335
Range on HMM: 155-218/263.0
EMAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGK----KILVHCQCGVSRSASLIVAYIM
| ..|.. |...    ... .. . ........... .     |.|||. ||.|....... |.
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii
0045450 (Phosphotyrosine protein) phosphatases II 277-369 2.4e-16 55.8 In-house 174-299 (307) alignment 
Range on Protein: 277-369
Range on HMM: 174-299/307.0
MAHKIKYYHIEWT-------------------HTSKIVKDLSRLTRIIHTAHS------QGKKILVHCQCGVSRSASLIVAYIMRYYG--------LSLN
  ........| |                      .. .... | ..|. ...      .|...||||  ||.|....|.||.| ...        ..| 
hldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdll

DAYNKLKGVAKDISPNMGLIFQLMEW
.|...|.     . .| . . .|.|.
eavkllreqRpgavqnpeqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 277-369 3.4e-16 55.0 In-house 184-284 (297) alignment 
Range on Protein: 277-369
Range on HMM: 184-284/297.0
MAHKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHS---QGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKLKGVAKDISPNMGLIFQLME
. . . |... . ..  ....| .. .....|..   .|...||||  ||.|....|.||.|     ...|... .|...|.     . .... . .|..
tvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyd

W
.
a
0040438 (Phosphotyrosine protein) phosphatases II 277-369 1.8e-13 45.9 In-house 152-271 (317) alignment 
Range on Protein: 277-369
Range on HMM: 152-271/317.0
MAHKIKYYHIEWTHT------------------SKIVKDLSRLTRIIHTAHSQ----GKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKL
  . |.....| ...                   .. .... | .... ....    |...||||  ||.|....|.||.|     ...|... .|...|
elagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel

KGVAKDISPNMGLIFQLMEW
.     . .. . . .|...
reqRpgavqtpeqyrflyda
0051429 (Phosphotyrosine protein) phosphatases II 277-369 3.1e-11 39.0 In-house 67-220 (272) alignment 
Range on Protein: 277-369
Range on HMM: 67-220/272.0
MaHKIKYYHIEWTHTSKIVK----------------------------------------------------DLsrLTRIIHTAHSqGKKILVHCQCGVS
  . |.|.|. .  .|                                                        .   | ....  .. |...||||  |..
w.pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkd

RSASLIVAYIMRyYGLS--------------LNDAYNKLKGVAKDISPNMGLIFQLMEW
|.. .......  .|.|              | .|...|. .   . .. . . .|.|.
RTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
0048567 (Phosphotyrosine protein) phosphatases II 277-355 3.8e-10 34.3 In-house 26-120 (157) alignment 
Range on Protein: 277-355
Range on HMM: 26-120/157.0
MAHKIKYYHIEW--THTSKIVK----DLS-------RLTRIIHTAHSQGKKILVHCQCGV---SRSASLIVAYIMRYYGLSLNDAYNKLKGVAKD
  .. .|..|.    . . . .    .|.       .| ....    .||.| |||  |    .|.| || .|.. ..|.. ..|.. |. |  .
slynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpg
subfamily_PTPDC1_pd Subfamily PTPDC1 277-347 2.2e-06 22.2 In-house 79-149 (182) alignment 
Range on Protein: 277-347
Range on HMM: 79-149/182.0
MAHKIKYYHIEWT-HTSKIVKDLSRLTRIIHTAHSQGkKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYN
|...| .| . |. . .. .. .  . .... | ..| |. |||  |  |   || .|..    |. ..| .
meqgiyvynfgwkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaik
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 278-371 4.8e-15 49.2 In-house 53-150 (154) alignment 
Range on Protein: 278-371
Range on HMM: 53-150/154.0
AHKIKYYHIEWTH--TSKIVKDLSRLTRIIHTAH--SQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGT
.  |.| ..|       .|.. |..    |. |    .  |.|||.. ||||||.|...|.|    .||  |.  ||     |.|| |.. ||  .. 
gfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 279-375 3e-14 46.8 In-house 162-260 (263) alignment 
Range on Protein: 279-375
Range on HMM: 162-260/263.0
HKIKYYHI---EWTHTSKIVKDLSRLTRIIHTAHSQGKkILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSK
.  ||. |   | .   .| . . ..   |.    .|  .||||. |||||..|...|.|..  | ...|..  .     | ||.|.. ||. .   |..
klfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
0036941 (Phosphotyrosine protein) phosphatases II 279-366 5.1e-12 41.2 In-house 168-269 (297) alignment 
Range on Protein: 279-366
Range on HMM: 168-269/297.0
HKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHS------QGKKILVHCQCGVSRSASLIVAYIM--------RYYGLSLNDAYNKLKGVAKDISPNMGLIF
......|.      ..  . . | ..|. ...      .|...||||  ||.||...|.|..|        ...|... .|..||.     . .. .   
rtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyr

QL
.|
fl
0046845 (Phosphotyrosine protein) phosphatases II 279-349 1.4e-09 33.2 In-house 165-249 (284) alignment 
Range on Protein: 279-349
Range on HMM: 165-249/284.0
HKIKYYHI-EWTHT-----SKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYY--------GLSLNDAYNKL
......|. .| .      .... .. || | .......|..|.|||  ||.|.. .|..... ..        |... .|...|
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrl
0051299 (Phosphotyrosine protein) phosphatases II 279-349 3.8e-09 31.9 In-house 182-261 (288) alignment 
Range on Protein: 279-349
Range on HMM: 182-261/288.0
HKIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQ----GKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKL
.... .|        .  ... | .... ....    |. ..|||  ||.|.. .|.....     . .|... .|...|
rtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrl
subfamily_DSP15_pd Subfamily DSP15 280-375 5e-18 59.6 In-house 46-141 (151) alignment 
Range on Protein: 280-375
Range on HMM: 46-141/151.0
KIKYYHIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTMLSK
. |..... |   |. | ..   ..||.. ......||||  |||||. |.|||.|    |. .|| . .|       ||.|   ||.|. .. .|
eYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklk
subfamily_DSP3_pd Subfamily DSP3 280-375 1.1e-16 54.9 In-house 62-159 (162) alignment 
Range on Protein: 280-375
Range on HMM: 62-159/162.0
KIKYYHIEWT--HTSKIVKDLSRLTRIIHTAHSQ-GKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGvAKDISPNMGLIFQLMEWGTMLSK
.|||. .| .   .... |  .. .. |..| ||   |.||||. |||||| |..||.| .  ..|..| .. .   ..| ||.| . ||.|  . |..
eikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrk.kReilPneGFlkqLaeldeelkr
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 280-369 1.4e-15 51.1 In-house 52-143 (148) alignment 
Range on Protein: 280-369
Range on HMM: 52-143/148.0
KIKYYHIEWTH--TSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEW
 |.|.|..        . .    ..  .. |...|...|||.| |||||. | .......   ||..|..  |   . . ||.| . || |.
gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLael
PTPc_DSPc_SM00012 282-335 8.5e-08 27.7 In-house 4-62 (105) alignment 
Range on Protein: 282-335
Range on HMM: 4-62/105.0
KYYHIEWTHTsKI---VKDLSRLTRIIHTAHSQ---GKKILVHCQCGVSRSASLIVAYIM
.|.. .|... ..   .... .| | ... ...   .| ..|||. ||.|.. .....|.
hyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldil
Y_phosphatase Protein-tyrosine phosphatase 282-335 5.2e-06 21.4 Pfam-A 137-193 (235) alignment 
Range on Protein: 282-335
Range on HMM: 137-193/235.0
KYYHIEWThTSKIVKDLSRLTRIIHTAHSQG----KKILVHCQCGVSRSASLIVAYIM
 . . .|.  ... .. . |...|.  ...     ....|||  ||.|....... |.
qlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
Y_phosphatase Protein-tyrosine phosphatase 282-335 5.2e-06 21.4 In-house 137-193 (235) alignment 
Range on Protein: 282-335
Range on HMM: 137-193/235.0
KYYHIEWThTSKIVKDLSRLTRIIHTAHSQG----KKILVHCQCGVSRSASLIVAYIM
 . . .|.  ... .. . |...|.  ...     ....|||  ||.|....... |.
qlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
0047943 (Phosphotyrosine protein) phosphatases II 283-350 2.2e-10 36.0 In-house 173-248 (273) alignment 
Range on Protein: 283-350
Range on HMM: 173-248/273.0
YYHIEWTHTSKIVKDLSRLTRIIHTAHS---QGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKLK
|...   ..   ...| .. .....|..   ......|||  ||.|....|.....     ...|... .|...|.
ytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllr
0050432 (Phosphotyrosine protein) phosphatases II 283-349 3e-09 32.1 In-house 201-274 (308) alignment 
Range on Protein: 283-349
Range on HMM: 201-274/308.0
YYHI-EWThTSKI---VKDLSRLTRIIHTAHsQGKKILVHCQCGVSRSASLIVAYIM-----RYYGLSLNDAYNKL
 .|   |    ..   ...| .. ..... . .|..|.|||  ||.|.. .|.....     . .|... .|..||
hfhytnWp.dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkkl
subfamily_MKPLT_pd Subfamily MKPLT 285-372 3.8e-16 53.1 In-house 72-159 (164) alignment 
Range on Protein: 285-372
Range on HMM: 72-159/164.0
HIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTM
..| . .... . | |..  .  |   | ..||||. |.|||.|  ||..... |  |..||. ||     ..|| |.. || ..  .
kvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 285-372 3.8e-16 53.1 In-house 72-159 (164) alignment 
Range on Protein: 285-372
Range on HMM: 72-159/164.0
HIEWTHTSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEWGTM
..| . .... . | |..  .  |   | ..||||. |.|||.|  ||..... |  |..||. ||     ..|| |.. || ..  .
kvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 287-347 6e-08 25.5 In-house 42-101 (128) alignment 
Range on Protein: 287-347
Range on HMM: 42-101/128.0
EWTHtSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYN
.|..  |. . .     |. . .     . |||.||. |.  .. .|.|.| | .|..| .
dwsa.dklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkale
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 287-347 6e-08 25.5 In-house 41-100 (128) alignment 
Range on Protein: 287-347
Range on HMM: 41-100/128.0
EWTHtSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYN
.|..  |. . .     |. . .     . |||.||. |.  .. .|.|.| | .|..| .
dwsa.dklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkale
subfamily_CDC14_pd Subfamily CDC14 289-345 3e-07 24.6 In-house 246-296 (328) alignment 
Range on Protein: 289-345
Range on HMM: 246-296/328.0
THTSKIVKdlsRLTRIIHTAhsqGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDA
| ...|||   ....|. .|     .| |||. |. |  .|| .|.|. |... ..|
tPsdaivk...kfleiaeka...eGaiavhCkaGLGrtGtLiacylmkhyrftaaea
subfamily_Laforin_pd Subfamily Laforin 291-344 3.9e-06 19.8 In-house 89-142 (183) alignment 
Range on Protein: 291-344
Range on HMM: 89-142/183.0
TSKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLND
|   |. | .   ..|.   .|... |||..|| ||..... ...   | ||. 
tesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslak
subfamily_PTPMT1_pd Subfamily PTPMT1 292-356 5.3e-11 37.2 In-house 87-151 (171) alignment 
Range on Protein: 292-356
Range on HMM: 87-151/171.0
SKIVKDLSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDI
.  ...|..  ..|.  .|.||.. |||. | .|||.|. .|.|  . ||...| . ||   | |
apdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkii
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 298-369 3.4e-11 36.4 In-house 66-137 (145) alignment 
Range on Protein: 298-369
Range on HMM: 66-137/145.0
LSRLTRIIHTAHSQGKKILVHCQCGVSRSASLIVAYIMRYYGLSLNDAYNKLKGVAKDISPNMGLIFQLMEW
.  .| .|   . .|  ..|||  ||||| .. ||..|.| ...| .|  ...       ||. .. .|.. 
fdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnl