Gene FIG4 in Saccharomyces cerevisiae

Synonym: YNL325C, FIG4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily FIG4
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP064_AA protein Get Run
ScerP064_AA_240-576 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Sac_COG5329 31-879 6.5e-307 1012.1 In-house 1-819 (1070) alignment 
Range on Protein: 31-879
Range on HMM: 1-819/1070.0
GKYTLYETKDRMYIVGSNKRETMFRILeidlTVPRGELTVLEDNVFFTRNEIMNVLASLEEAtedglHKKITGYGLLgfiKFTCWYYLIMVTKYSQV-AV
.|..|.|.|.|.....|||....||.|    .|...||.|.................||..|     |......||.   .......||..|..|.| .|
MkillsekktRsiaivsnkyalvfrrl....svknselsvcaaelvavselkkegfrslssa.....heiygvlGli...elegslflivitgkskvaqv

IGGHGIYHIDGIDIIPITNNYKKPEKSS-DEARLLN--------IFKDLDLTKTFYFSYTYDITNTLQTNiLREKLKAVDRCDITIPCGITDYNEMFVWN
|.|..||.|...|.|...||....|... |||.. .        ..|.|. ...||||...|||||||.. |.|.|..................|.....
ipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfStdfditntLqkr.lkeelelsvdtadeefmwnsflleeliny

NNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMiltpfhqpgngffdsDRYTSF
.. ||................|.||...|...| .|.|..|||.|||...||.|||.|||...|.|||.|||||||...               ....||
rsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGnvanFVETEqIvyss...............qycfsF

VQHRGSIPLYWTQDaSNLTTKPPIRINVVDP-FFSPAALHFDNLFQRYGGgtIQILNLIKTKEktpRETKLLWEFEQCIDyLNEFLPTlkklDYTSWDMS
.|.|||||..|.|. ||....|.|.|..... ..|... |||.||..||.  ..|.||.|||.   .|..|....|.... |.|....    ..|..|..
tQvRGSiPiFWeqe.snsligpkiqitrsseatqsafdkHFdklfekYGd..vhivNLlktKs...sEieLseryekhlk.lsekpki....hlteFdfh

RASKQDGQGVIEFLEKYAVNTvTTTGIFHN--GPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIIDNSYLEydsDIVNILTELFHD
....|||......|....... ........  .........|.|..|.||.|||||||..|..|.||.|..|..|...|.... |   |....|.||..|
ketsqdgfddvkkLlplieqd.llefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde...dflqklneLWad

LGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFPSLWEMNTDFYLHNAYSLNMPKRSYIHWWNDY
 ||.|. .|.|.. .....|............|...|..|.|.|.|||...||||.|.||.....|........|....|....|...............
nGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpdqeavelydpineyvnlrlrkseseftaaknvsiftl

NIKSVKELINEELIATGNDVTREKIIKNVRGYPGAFDNYWNEYYLPRSVTWIRDLFAYNMNSTRRYHNALSKQDKAMSPFTSRKQSWLNNKLKMITSSKS
...|..|.....|......|...||.|.|.|..|.....|.|..|..|.|.... .....|..|.|.|.|.|.....|.........|..| ..|....|
tfnsngessstkllklllkvlekkisklvvgvvglqkqiwlelillssltksefkeeeeenlvrkyenklkkkkleqsssqltalfilfkksadikevvs

LEKAEGRVVETTDLDRDTSPKQELELYEHYLHIISDRSQKLEEKMNSFSYSKYPIFISHESSEIPPMRKVIGEPLVDIAEDFTDVYDDDDDGDDENDEMT
 |||.||...|..|......... ...|....|..|.|..||....|...|||.......|.|||.|.|.....|.|||...|..||..........|..
sekaagrktgtgglnankgavkieaeseglvfifvdasaaledenesernskyesitkrvskeipkmikdhqlilldiainltidydeeevraekekeid

TEALLIAPDHVSVDEKFYEKVLNVDDYKPALDDYSAVIHIKPDNLQLYRDLCFSKDIQLDFQ
.|.  ...........|.||||........|...|.......|. ..||.|...|.|| ...
relkkydtkqeltekvfvekvleptevpellekksyeddndtdtedayrklrtrkliqkeek
subfamily_FIG4_pd Subfamily FIG4 33-607 0.0 1033.1 In-house 1-569 (569) alignment 
Range on Protein: 33-607
Range on HMM: 1-569/569.0
YTLYETKDRMYIVGSNKRETMFRILEIDLTVPRgELTVLEDNVFFTRNEIMNVLASLEEATEDGLHKKITGYGLLGFIKFTCWYYLIMVTKYSQVAVIGG
..|||||.|.|.||||||||.||.|.||.||.| ||.||||.|.||.|||...|||||||..|||.||...||.|||..|...||||.|||...||||||
lvlyetkarlylvGsnkretkfrvlkidrtver.elvvledkveftkneikellasleeanrdglekkvsayGilGfvrflegyylilvtkrkkvaviGg

HGIYHIDGIDIIPITNNYKKPEKSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNIL-----REKLKAVDRCDITIPCGITDYNEMFVWNNNLLSPI
|.||.|..|..|.||...||.||||||||.|..|||.||||.|||||.||.|.|||||.|     ||| ||.||.||||.....|.||.|||||.||.|.
haiykiedialikitedskksekssdearylklfkdvdltknfyfsysydltrtlqtnlllsdsnrekekaedrvditieakkldanekfvWnnfllepl

FACIDTvFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVtdmiltpfHQPGNGFFDSDRYTSFVQHRGSI
.....| |||...|||||..|...||||||||.|||||||..|||||||||||||||.|||||||||||        |....|..|||||.||||.|||.
kdtvkt.fdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqiv........heasegsldsdryssfvqlrGsv

PLYWTQDASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYGGGTIqILNLIKTKEKTPRETKLLWEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQDGQ
||||.||||.|.|||||.|.|||||.|.||||||.||||||...| ||||.|.|||..||..||.|||..|.|||||||. |||.|.||||.||||....
PlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspii.ilnlvkkkekrkresilleefeaaieylneflPeekklkyiswdmaraskskee

GVIEFLEKYAVNTVTTTGIFHNGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIIDNSYLEYDSDIVNILTELFHDLGDTIALQYG
.|.|.|||||...|..||||...||..||||||||.|.||.|||||||||||||||.|||.|||||||||.|.||.|||.|..|.||..|||||.|||||
nvlevlekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiidesklefdsdvvrlleelyedlGdtlalqyg

GSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFPSLWEMNTDFYLHNAYSLNMPK
||.||||..|||||.||||.|||..|..||.||||||||..|||||||||.||.|||.|||||..|||||||||||..||
GsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspreglpslWeletdfylhnayslklpk
subfamily_Synaptojanin_pd Subfamily Synaptojanin 101-578 2.4e-55 179.3 In-house 4-434 (754) alignment 
Range on Protein: 101-578
Range on HMM: 4-434/754.0
ITGYGLLGFIKFT----CWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEARLLNifkdldlTKTFYFSYTYDITNtlqtnilreKL
.  ||||| .. .       .|..||  ..|  | .  |..|  ...... .. .. .. ..  .||.       ..||||| . | ..         .|
vdaygllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvslrseasdedriielkklla.......sgtfyfsssadsas.........rl

KAVDRCDITIPCGITdyNEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIV
.   ...       .  .. |.||  |   .        ||.  .. | ..   | .  | . ..||.| |   || ||  ||||..|.||| |||||..
dlslsaqrrkqeese..dnrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvi

tdmiltpfhqpgngFFDsDRYTSFVQHRGSIPLYWTQDASNLTTKpPIRINVVDPFFSPA-ALHFDNLFQRYGggTIQILNLIKTKEKtprETKLLWEFE
              ..| |. ||||| |||.||.| |   .  ..  ....      ..|   |...| .|||  .. |.||. .||    |. |  .|.
..............lld.dkvtsfvqirGsvPlfWeqPGlqvGsh.kvklsrgfeasaaafdrhleqlkeryG..evvivnllGskeg...eevlskafk

QCIDyLNEFLptlKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNT-VTTTGIFHNGpDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLG
.     .|.    |.... ..|. .  |.. . ..| | | .... ......|..  .   .| |.|. |.||.|||||||| | |.|   |  ||. |.
khlk.aseha...kdvpfvkfdyhqkvkggkkeklekllkkqlklflesasfflsk.gkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk

iiDNSYLEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMEtyrKinqwSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGH
   .|  .  | . .....|..  || |.  | |.  ...     |    .|  .|.  |..|   | |.|...|.||.|.|  
..lsskesvvsrfeevfkslWsknGdeiskiyaGtgalegka...k....vsklkdgarsvartiqnnfldsskqeaidllllg
Syja_N SacI homology domain 104-424 1.4e-94 307.9 Pfam-A 2-314 (319) alignment 
Range on Protein: 104-424
Range on HMM: 2-314/319.0
YGLLGFIKFTCWYYLIMVTKYSQVAVIG-GHGIYHIDGIDIIPITNNYKKPE--------KSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNILRE
||.||.|...  .||...||...|| |. .| ||.|. ...||.... .. .        ....|..||. .|.|. ...|||||.||.|..||..  .|
ygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrkseke

KLKAVDRCDITipCGITDYNEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVL-GKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETE
. .. .. . .    . ...|.||||.|||.|.  .   . .|. ..|.||..| ...|  .|....|||.||| ..||.|.|.||....|.|||.||||
eeekeeesksl..pllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtE

QIVTDmiltpfhQ-PgngffDSDRYTSFVQHRGSIPLYWTQdASNLTTKPPIRIN-VVDPFFSPAALHFDNLFQRYggGTIQILNLIktkEKTPRETKLL
|||..       . .      |.|..||||.|||.||.|.| ||||. ||.|.|.   ..  . ...||..|..||  | |...||.   ||..|| || 
qivse.......kke.....eskrvfSfvqiRGSvPlfWeq.asnlslkpkikitrsseasqkafkkHfkklikrY..gkivvvnLl...ekkgrEkkLs

WEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQ
 ..|..|..||..|.. |||.|...|.... |.
eayeelinklnkklkekkklkyiefDfhkeckg
Syja_N SacI homology domain 104-424 1.4e-94 307.9 In-house 2-314 (319) alignment 
Range on Protein: 104-424
Range on HMM: 2-314/319.0
YGLLGFIKFTCWYYLIMVTKYSQVAVIG-GHGIYHIDGIDIIPITNNYKKPE--------KSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNILRE
||.||.|...  .||...||...|| |. .| ||.|. ...||.... .. .        ....|..||. .|.|. ...|||||.||.|..||..  .|
ygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrkseke

KLKAVDRCDITipCGITDYNEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVL-GKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETE
. .. .. . .    . ...|.||||.|||.|.  .   . .|. ..|.||..| ...|  .|....|||.||| ..||.|.|.||....|.|||.||||
eeekeeesksl..pllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtE

QIVTDmiltpfhQ-PgngffDSDRYTSFVQHRGSIPLYWTQdASNLTTKPPIRIN-VVDPFFSPAALHFDNLFQRYggGTIQILNLIktkEKTPRETKLL
|||..       . .      |.|..||||.|||.||.|.| ||||. ||.|.|.   ..  . ...||..|..||  | |...||.   ||..|| || 
qivse.......kke.....eskrvfSfvqiRGSvPlfWeq.asnlslkpkikitrsseasqkafkkHfkklikrY..gkivvvnLl...ekkgrEkkLs

WEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQ
 ..|..|..||..|.. |||.|...|.... |.
eayeelinklnkklkekkklkyiefDfhkeckg
subfamily_SAC1_pd Subfamily SAC1 104-580 1.7e-92 301.5 In-house 8-454 (458) alignment 
Range on Protein: 104-580
Range on HMM: 8-454/458.0
YGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPE--KSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNilreklKAVDR
.|.||.||     |||..|| ..|. | |. ||..  ..|||...| ..    . ..|.. |.. ...  ..|||||||||.||.|| .      . |  
agilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrl......ekvts

CDITIPCGITDYNEMFVWNNNLLSPIFAcIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMil
  ..    .   .| |.||. ||. . .  . . .. . .|.|||.....|. .|.|  .||.||| . ||.|. .|||...|.||| |||||||.    
aalkerslleradeRffwnkhlledlrk.epelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveae..

tpfhqpgngffdsDRYTSFVQHRGSIPLYWTQdASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYggGTIQILNLIKTKektPRETKLLWEFEQCIDYL
                ||||| ||||||.|.|  .||  || ....  .   .    |.|.. ..|  |   ..||.  |    .|.||  ..|. .  |
.............kaltsFvqvRGsiPllWsq.kpnLkykPkvklsesedsldafkkhldeqiely..genvlvnLvdqk...GsEkklgeayesvvral

NEflptlKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNTVTTTGIFHNGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIID-NSY
|.     ||..|...|  .  ..     .. | .   ...  .|.|.   .   .| |.|. |.||||||||||  | ......|  ||.|||..  .| 
nk.....kkikyvafDFHkeCrkmrwdrlklLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlatesk

LEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYS
||  ... ..  .|. | .|... || |     |  |     . .   ||...|..|.| | |.| .|||.|.||||.|.
ledsaeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyr
subfamily_INPP5F_pd Subfamily INPP5F 144-579 3e-73 238.4 In-house 107-506 (951) alignment 
Range on Protein: 144-579
Range on HMM: 107-506/951.0
IPITNNYKKPEKSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNILREKLKAVDRCditipcgitdyNEMFVWNNNLLSPIFACIDTV-FDWFQCII
   ... .. |..  | |||.  | |   ..||.|...|.||||| . | || . .|             .| |.||..||... .  |.    .   .|
lqlkeekeqneeeklekrlleelkkllsdgsFYysldfDltntlqkrgleeksestddw...........derFfWNkfllkdlinyrdkldkefltpvi

HGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTdmiltpFhqpgngffdSDRYTSFVQHRGSIPLYWTQDasNLTTKP
 ||.   ..|.  . . .||| ||| . ||.|| .||....|.|||.||||.|..      .         ..   ||.| |||.|..|.|.  .   ||
qGfvetkeisieklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElils......v.........ekyvlsftqirGSvPvfweqs..gkkykp

PIRINVVDPFFSPA-ALHFDNLFQRYGGgtIQILNLIKTKEktpRETKLLWEFEQCIDYLNeflptLKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNTV
.|.|.  .    ||   ||......||   . | ||...|.   .| ||   ... .  |.      |.. ... |. . .....   .. | ..  |..
kikitrseeetqpaFdehfkeqlkkygk..vvivnllsqks...sekklskaykeqllkle.....skdvflikfdfheetsgekfenvsklieliknei

TTTGIFHNGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIIDNSYLEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRKI
.. | | .  .      |.|. | ||.||||||| .|  |.| .|  ||. ||... .  . |..... | .|. | ||.|  || |.. .    |    
kevgyfsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdltrkge

NQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHY
.. .    |  .|..|.| | |.|..||..|.| ||. 
rklaGvlkdgyksvsryylnnfkdkyrqkvidlllGkl