Gene PTP2 in Saccharomyces cerevisiae

Synonym: YOR208W, PTP2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Fungi-PTP2
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP070_AA protein Get Run
ScerP070_AA_366-739 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 229-293 3.7e-20 66.6 In-house 284-349 (349) alignment 
Range on Protein: 229-293
Range on HMM: 284-349/349.0
TLNLRIN--IPPPNDSNKIFLQSLKKDLIHYSPNSLQKfFQFNMPADLAPNDTILPNWLKFCSVKEN
||.|...  .|..|.||||.||.|.||||....|.|.| ....|...||....|....||....|..
tldlllsileplqnesnkiklqallkDlisiivnelrk.qrismvqnlaqfiaiyealLkyfalkkd
DSPc_SM00195 353-738 1.9e-78 258.8 In-house 2-262 (263) alignment 
Range on Protein: 353-738
Range on HMM: 2-262/263.0
LQRQYKSSLKSNIQKnQKLKLIIPKNNtssspsplssddtimspindyeltegiqsfTKNRYSNILPYEHSRVKLPHSPKPpavseasttetktdksypm
|.........|. .| .. . ...||.                              .||||.|||||.|.||||....|.                   
lkeefekleestspk.etteaekkknk..............................sknRyknilpydhtrVklkkeekk...................

cpvdaknhscKPNDYINANYLKLTqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL--SYSNHT-IKLQNTWENICN
          ...|||||||.|..  |.. ||||||.|||||..|||.... .|||.|..|....| . .|.| ||..   ...... |...........
..........egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk

iNGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmavSEPFIVYQLQYKNWLDScGVD---MNDIIKLHKVKNSLLFNpqsfitslekdvckpdlid
 . ..||.....|...                        .|.. |.|.||||| |. ||.   .. .  |..||.|   .                   
.deiilrtleltkegk........................eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts...................

dnnselhldtanSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNhsnkidvwnmtqDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
            |.|..||||||.||||.|||.|..|| |. ...            . || ||.||||||..|||.|.||...|||.|.|.
............sgpivVhCsaGvgRtgtfvtidiilskleeekk............vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 353-738 1.9e-78 258.8 In-house 2-262 (263) alignment 
Range on Protein: 353-738
Range on HMM: 2-262/263.0
LQRQYKSSLKSNIQKnQKLKLIIPKNNtssspsplssddtimspindyeltegiqsfTKNRYSNILPYEHSRVKLPHSPKPpavseasttetktdksypm
|.........|. .| .. . ...||.                              .||||.|||||.|.||||....|.                   
lkeefekleestspk.etteaekkknk..............................sknRyknilpydhtrVklkkeekk...................

cpvdaknhscKPNDYINANYLKLTqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL--SYSNHT-IKLQNTWENICN
          ...|||||||.|..  |.. ||||||.|||||..|||.... .|||.|..|....| . .|.| ||..   ...... |...........
..........egsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk

iNGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmavSEPFIVYQLQYKNWLDScGVD---MNDIIKLHKVKNSLLFNpqsfitslekdvckpdlid
 . ..||.....|...                        .|.. |.|.||||| |. ||.   .. .  |..||.|   .                   
.deiilrtleltkegk........................eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts...................

dnnselhldtanSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNhsnkidvwnmtqDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
            |.|..||||||.||||.|||.|..|| |. ...            . || ||.||||||..|||.|.||...|||.|.|.
............sgpivVhCsaGvgRtgtfvtidiilskleeekk............vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 359-743 1.3e-191 630.4 In-house 1-349 (349) alignment 
Range on Protein: 359-743
Range on HMM: 1-349/349.0
SSLKSNIQKNQKLKLIIPKNNTSSSPSPLSSDDTimSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPAVSEASTTETKtdksypmcpvdak
||.||..||..||||||.|...|.|...|.|||.  |.|.|..|.||...|.||||..|||||||||||..|.|...|..|||.|..             
ssdkskvqkrsklkliitkysksksmlslesddd..seiddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesd.............

nhSCKPNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVF
  |.|..|||||||||||.|....||||||||||||.|||.|||.||.||...|||.|.||.|.|.||||..|||||.|.||||....|.|..|..|||.
..sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyianvqGnslrvs

QVKKTAPQNDNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLDScgvdmndiiklhkvknSLLFNPQSFITSLEkdvCKPDLIDDNNSELHLDTAN
.||.|...|||....||||...|...|..||..|....|||.|||||.                |||.||.|....||   .|.|||||....|.|||..
tvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldl................slllnPisilqale...vkndliddlfarlyldtdq

SSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSNKIDVWNMTQDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQ
.|.||||||||||||||.||||.|||||.|..|.||||.......|||.|||||||||||||||||.|.||.|||||.||||.|.
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalkkd
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 360-744 4.3e-179 589.6 In-house 1-350 (350) alignment 
Range on Protein: 360-744
Range on HMM: 1-350/350.0
SLKSNIQKNQKLKLIIPKNNTSSSPSPLSSDDTimSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPavseasttetktdksypmcpvDAKN
|.||..||..||||||.||.|..|...|.||..  ||.||..|.||...|.||||.||||||||||||..|.|..                     |||.
sdkskvqkrsklkliitknstvksrlsLesdse..spsnDvilseGvelfaknrYknilPYehsrvkLkkslkss.....................dakk

HSCKPNDYINANYLKLT----QINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVL
||...||||||||||||    .|||||||||||||||||.|||.|||.|||||||.||.||.||||.|...||...||...|.||...||||..||...|
hslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindssl

RVFQVKKTAPQNDNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLDScgvdmndiiklhkvknSLLFNPQSFITSLEkdvCKPDLIDDNNSELHLD
....|||.|..|||||.|.||..|..||.||.|.|.|..|||||.|||.|.                |||.||.|....||   .|.|||||...|.|||
ysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDl................slllnPesilqale...vkndliddlfaeshld

TANSSPLLVHCSAGCGRTGVFVTLDFLLS---ILSPTTNHSNKIDVWNMTQDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQI
.|.|||.|||||||.||||..||||.|||   ||...|..|.|.||...|.|||.|||||||||||||||||.|.|..|||||.||||.|.|
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfaLrkdi
0039614 (Phosphotyrosine protein) phosphatases II 391-739 3.8e-53 176.2 In-house 39-290 (297) alignment 
Range on Protein: 391-739
Range on HMM: 39-290/297.0
DTIMSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPkppavseasttetktdksypmcpvdaknHSCKPNDYINANYLKLTQINPDfKYIATQAP
 ...| . ||. .. ... .||||..||||.|||||| . .                            ..  ..|||||.|..   .... |.||||.|
eellslkpdysiallpenkdknrykdilpydhsrvklkped............................gvdldsdYinAsyvdgydlltr.kfIatqgP

LPSTMDDFWKVITLNKVKVIISLNSDDELNLrKWDIYWNNLSYSNHTIKLQNTWENIcnINGCVLRVFQVKKtapqNDnisqdcdlphngdltsitmavs
||.|..|||. .  ..|.||..|.. .||.  |.. || . .   ....  .. .     .|...|.. |..    |.                      
lpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkveh..ldgytvrtlevtn....ng......................

EPFIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLFNpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPT
|...|...|| .| | .   ........ .  .. | .                            . .. | |||||||.||||.|.... .|. |  .
esrtvthfqytgwpdhgvppslellleflelvrealae............................lpkggpvlVHCsaGvgRtGtfiaaylmleqleke

TNHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
 . .            .. .|.|||.||  .||.. ||. .|.||| .. 
ggvd............vleavkelreqRpgavqtpsqyrflydallellk
0045098 (Phosphotyrosine protein) phosphatases II 392-738 8.9e-50 165.0 In-house 17-272 (278) alignment 
Range on Protein: 392-738
Range on HMM: 17-272/278.0
TIMSPINDYELTEGIQSFTKNRYSNILPYEHSRVKlphspkppavseasttetktdksypmcpvdaknhsckpnDYINANYLKLTqinpDFKYIATQAPL
 .........    . .. ||||..||||.|||||                                       |||||.|..      ..|.||||.||
lllgipseitpalylgnldknRykdilpydhsrVk.......................................dYINAsyidgy....pkkfIatqgPl

PSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTWENicniNGCVLRVFQVKKTA----Pqndnisqdcdlphngdlts
|||..|||. .  ....||..|..  ||.  |.. || .   | | . |..|... ..    .  .||.. |  .                         
pstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevl....ddytlrtllvtnltvered...................

itmavSEPFIVYQLQYKNWLDSCGVDMN---DIIKLHKVKNSLLFNPQSFITSLEkdvckpdliddnnselhLDTANSSPLLVHCSAGCGRTGVFVTLDF
      |.. |..|.|..| | .  ...    ...| .  .. | . .|...|                   |   .. | |||||||.||||..| .. 
.....lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl.................llldsggpvlVHCsaGvgRtGtlvaayl

LLSILspttnH---SnkidvwnmtqdlIFIIVNELRKQRIS-MVQNLTQYIACYEALLNYF
.|. |     .   .            .. .|.|||.||   .|||| ||. .||.|| ..
mlell.....eggvd............lleavkelrsqRpglavqnleqyrflyefllell
0050432 (Phosphotyrosine protein) phosphatases II 395-742 1.4e-57 190.7 In-house 55-303 (308) alignment 
Range on Protein: 395-742
Range on HMM: 55-303/308.0
SPINDYELTEGIQSFTKNRYSNILPYEHSRVKLphS-PkppavseasttetktdksypmcpvdaknhsckpNDYINANYLKLTQINPDFKYIATQAPLPS
 |...|. ..  . ..||||..||||.||||||  . .                                 .|||||.| .. . . . |.||||.|||.
kplleysvallpenkdkNrykdilpydhsRVkl..deg.................................sdYInAsyvdgyssklprkfIatqgPlpn

TMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYW------NNLSYSNHTIKLQNTWEnicnINGCVLRVFQVKKTApqndnisqdcdlphngdltsitm
|..|||. .  ..|.||. |.. .| .  |.. ||      . | | . |..| .. .     .....|.......                        
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev....lddytvrtleltnlg.......................

aVSEPFIVYQLQYKNWLDSCGVD-MNDIIKLHKVKNSLLfnpQSfitslekdvckpdliddnnselhldtansSPLLVHCSAGCGRTGVFVTLDFLLSIL
  .| ..|....|.|| | .  . ....... .  .. |   ..                             .| .||||||.||||.|..|| ||. |
.dgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pg.............................gpivVHCsaGvGRtGtfialdllleql

SPTTNHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQK
  . . .            .| .|. ||.||  |||.. ||. .|.||| |. | .
ekeggvd............vfeavkklReqRpgmvqtpeqylflyralleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 396-738 4.8e-56 185.7 In-house 37-286 (288) alignment 
Range on Protein: 396-738
Range on HMM: 37-286/288.0
PINDYELTEGIQSFTKNRYSNILPYEHSRVKLPhspkppavseasttetktdksypmcpvdaKNHSCKPNDYINANYLKLTQINPDfkYIATQAPLPSTM
| ...  .   . ..|||||.||||.||||||                                ... ..|||||.|... ...    .||||.|||.|.
pdltlsaallpenleknRysdilpydhsRVkLs.............................vldgvegsdYinAsyidgynlkrk..fIatqgPlpntv

DDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN---NLSYSNHTIKLQNTWEnicnINGCVLRVFQVKKTAPQNdnisqdcdlphngdltsitmAVSEP
.|||. .  ..|.||..|.. .||. .|.. ||.    | | . |..| .. .     .....|...|...   .                      .|.
edFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev....lddytvrtlevtnldlld....................gdges

FIVYQLQYKNWLDSCGVD-MNDIIKLHKVKNsllfnpqsfitslekdvckpD--LiddnnselhldtANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPT
..|....|.|| | .  | ....... .  .                    .               ....| .||||||.||||.|..|| ||. |  .
rtvthfhytnwpdhgvpdspellldflrlvr....................kala............sgggpvvVHCsaGvgRtgtfialdllleqleke

TNHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
   .            .. .|. ||.||  |||.. ||. .||||| |.
ggvd............vleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 396-739 5.6e-56 185.5 In-house 31-277 (317) alignment 
Range on Protein: 396-739
Range on HMM: 31-277/317.0
PINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHspkppavseasttetktdksypmcpvdakNHSCKPNDYINANYLKLTQINPDfkYIATQAPLPSTM
....|. .|  ..  ||||..||||.|||||| .                               .  ..|||||.| .  ....   .||||.|||.|.
kldtysvaelpenkdknrypdilpydhsRVkLsp.............................lggdldsdYInAsyvdgpnlkrk..fIatqgPlpntv

DDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN---NLSYSNHTIKLQNTWEnicnINGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmavSEP
.|||. .  ..|.||..|.. .||. .|.. ||.    | | . |..|... |     .|..||...|...                          ||.
edFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee....lagitlrtlevedlgd........................ses

FIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLfnpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTN
..|....|..| | .   ........ .  .. |                                ...|.|||||||.||||.|.... .|. |  . .
rtvthfhytgWpdhgvppspdllldfleavreal..............................edpggpvlVHCsaGvgRtGtfiaaylmleqlekegg

HSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
 .            .. .|.|||.||  .||.. ||. .|.|||.|. 
vd............veeavkelreqRpgavqtpeqyrflydalleylk
0047943 (Phosphotyrosine protein) phosphatases II 396-738 1.9e-51 170.5 In-house 26-272 (273) alignment 
Range on Protein: 396-738
Range on HMM: 26-272/273.0
PINDYELTEGIQSFTKNRYSNILPYEHSRVKLphspkppavseaS----TtetktdksypmcpvdaknhsckpndYINANYLKLTQINPDfkYIATQAPL
|. .|. .. .. ..||||..||||.||||||            .                              ||||.|... ....   .||||.||
plltysvallpenkdknrykdilpydhsrvkl............gdggsd.........................yinAsyvdgynlkrk..fiatqgPl

PSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN------NLSYSNHTIKLQNTWEnicnINGCVLRVFQVKKTApqndnisqdcdlphngdltsi
|.|..|||. .  ..|.||..|....||. .|.. ||        | | . |..| .. .     .....|.......                      
pntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet....kddytvrtleltnlg.....................

tmaVSEPFIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLFnpqsfitslekdvckpdliddnnselhlDTANSSPLLVHCSAGCGRTGVFVTLDFLLS
    .|...|....|..| | .   ........ .. .. |                              . ...| .||||||.||||.|..|| ||.
...tgesrtvthfhytgwpdhgvppslesllefielvrkale............................alpsngpvvVHCsaGvgRtgtfialdllld

ILSPTTNHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
 |  . . .            .. .|. ||.||  |||.. ||. .|||||.|.
qlekeggvd............vleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 397-743 3.5e-57 189.3 In-house 28-282 (297) alignment 
Range on Protein: 397-743
Range on HMM: 28-282/297.0
INDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPkppavseasttetktdksypmcpvdaknhsckpNDYINANYLklTQINPDFKYIATQAPLPSTMD
. ... ..  .  .||||..||||.|.||||....                                 .|||||.|.  .  . ..|.||||.|||.|..
lgslsvallpenleknRykdilpydhtRVklddeg.................................sdYinAsyv..dgydlkrkfIatqgPlpntve

DFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL-----SYSNHTIKLQNTWENicNINGCVLRVFQVKKTapQNdnisqdcdlphngdltsitmavSE
|||. .  ..|.||..|....||.  |.. || .       | . |..|... .   . ....||...|..|  .|                      .|
dFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv..llddytlrtlevtdt..gn......................ge

PFIVYQLQYKNWLDSCGVD-MNDIIKLHKVKNSLLfnPQSfitslekdvckpdliddnnselhldtANSSPLLVHCSAGCGRTGVFVTLDFLLSILS---
...|....|..| | .  . ....... .  .. |  ...                           ...| |||||||.||.|.|...| .|. |    
srtvthfhytgwpdhgvpespaslldfielvrkvl..kll..........................psggpvlVHCsaGvgRsgtfiaadlmlqqledkl

PTTNHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQ
 . . .            |. .|..||.||  .||.| ||. .|||||...  ...
keggvd............ileavkklReqRpgavqtleqyrflyeallellkkklt
0045450 (Phosphotyrosine protein) phosphatases II 397-738 2.7e-54 180.3 In-house 44-304 (307) alignment 
Range on Protein: 397-738
Range on HMM: 44-304/307.0
INDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPkppavseasttetktdksypmcpvdaknHSCKPNDYINANYLKL------TQINPDFKYIATQAP
...|. ..  .. .||||..||||.|.|||| . .                            .| ...|||||.| ..         . . |.||||.|
lgeysiallpenkdknrykdilpydhtRVklssld............................gsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

LPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL----SYSNHTIKLQNTWEnicnINGCVLRVFQVKKTAPQNdnisqdcdlphngdltsit
||.|..|||. .  ..|.||..|....||. .|.. || .      | | |..| .. .     .|...|.. |. . . .                   
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh....ldgytvrtlevtdldgtg...................

mavsEPFIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLFNpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSI
    |...|....|..| | .   ........ .  .. | .                            . ...| |||||||.||||.|.... .|. 
....esrtvthfhytgwpdhgvppsfeelldfieevrkalee............................lpkggpvlVHCsaGvgRtGtfiaaylmlrq

LS--------PttnhsnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
|         .                 .. .|..||.||  .|||. ||. .||||| ..
lekegtlldvd.................lleavkllreqRpgavqnpeqyrflyeallell
0046845 (Phosphotyrosine protein) phosphatases II 397-743 2.5e-53 176.6 In-house 17-279 (284) alignment 
Range on Protein: 397-743
Range on HMM: 17-279/284.0
INDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPkppavseasttetktdksypmcpvdaknHSCKPNDYINANYLKLTQI---NPDFKYIATQAPLPS
. ... .   . ..||||..||||.|||||| . .                            .... .|||||.|..  ..   .   |.||||.|||.
llslsvallpenlsknRykdilpydhsRVklksld............................gdledsdYinAsyvdgydldltyikkkfIatqgPlpn

TMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLS----YSNHTIKLQNTWEnicnINGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmaV
|..|||...  ..|.||..|.. .| .  |.. ||.. .    | . |..| ....     .....|....... .                        
tvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev....kddytvrtleltnlgy.......................t

SEPFIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLFNpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSP
.|...|....|..| | .   ...|.... .  ..|| |                            . ...| .||||||.||||.|..|| ||. |  
gesrtvthfhytswpdhgvppspedlleflrlvrellen............................lpgggpivVHCsaGvgRtGtfialdllleqlek

TT---NHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQ
.    . .            .. .|. ||.||  |||.| ||. .|||||.|. | ..
eglllgvd............vleavkrlreqRpgmvqtleqyrfvyealleylklklt
0043336 (Phosphotyrosine protein) phosphatases II 398-738 6.7e-54 178.6 In-house 35-277 (278) alignment 
Range on Protein: 398-738
Range on HMM: 35-277/278.0
NDYELTEGIQSFTKNRYSNILPYEHSRVKLPHspkppavseasttetktdksypmcpvdakNHSCKPNDYINANYLKLTQINPDfkYIATQAPLPSTMDD
..|. .. .....||||..||||.|||||| .                               .. ..|||||.|... .....  .||||.|||.|..|
dtysiallpenkdknrykdilpydhsrvklsl.............................lggdldsdYinAsyvdgynvprk..fiatqgPlpetved

FWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENIcnINGCVLRVFQVKKTAPQndnisqdcdlphngdltsitmavsEPFIVYQ
||. .  ..|..|..|....||.  |.. ||.. |.  ....  .. |.    .....|.. |...                           |...|..
FwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeeh..lddytvrtlevtnlgdg........................esrtvth

LQYKNWLDSCGV-DMNDIIKLHKVKNSLLfnpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSnki
..|..| | .   ........ |. .. |                                ...|.|||||||.||||.|..|. ||. |  . . .   
yhylgwpdhgvpeslsllldflkavreal..............................edsngpvlVHCsaGvgRTGtfialyllleqlekeggvd...

dvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
         .. .|.|||.|| ..||.. ||. .||||| |.
.........leeavkelreqRpgavqtpsqyrflyealleyl
0040439 (Phosphotyrosine protein) phosphatases II 399-738 1.9e-49 163.9 In-house 2-246 (249) alignment 
Range on Protein: 399-738
Range on HMM: 2-246/249.0
DYELTEGIQSFTKNRYSNILPYEHSRVKLPHspkppavseasttetktdksypmcpvdakNHSCKPNDYINANYLKLTQINPDfkYIATQAPLPSTMDDF
.|. ..   .  ||||..||||.|||||| .                               .. ..|||||.|.....|...  .||||.|||.|..||
eysvallpenkdknrypdilpydhsrvklsi.............................lpglflsdyinAsyidgyyikrr..fiatqgPlpetvedf

WKVITLNKVKVIISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTWEnicnINGCVLRVFQVKKTApqndnisqdcdlphngdltsitmaVSEPFIV
|. .  ....||..|.|..||.  |.. ||..   | | . |..| .. .     .....|.......                          .|.. |
wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvev....kddytvrtleltnly........................dgesrtv

YQLQYKNWLDSCGV-DMNDIIKLHKVKNsllfnpqsfitslekdvckpdliddnnseL----HldtANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTT
...|| .| |     ...|.... .  .                                       ...|.|||||||.||||.|.... .|. |  . 
lhiqytdwpdhgvppsfedlldfieavr.............................kaleel...pkggpvlVHCsaGvgRtGtfiaaylmleqlekel

NHSnkidvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
. .            .. .|..||.||  .|||. ||. .||||| ..
gvd............leeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 403-738 5.9e-49 162.0 In-house 4-243 (245) alignment 
Range on Protein: 403-738
Range on HMM: 4-243/245.0
TEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPAVSeasttetktdksypmcpvdaknhsckpndYINANYLKLTQINPDfkYIATQAPLPSTMDDFWKVI
.. . . .|||||.||||.|.||||.. .  . ..                             ||||.| .. .|.|   .||||.|||.| .|||. .
allpenkdknrysdilpydhtrvklspdggdldsd.............................yinasyvdgyritpk..fiatqgPlpetvedfwrml

TLNKVKVIISLNSDDELNLRKWDIYWNNlSYSNHTIKLQNTWENICNINGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmavSEPFIVYQLQYKN
  .....|..|....||.  |.. ||.. . |  . ... |. .. . .....|...|...                          .|.. |....| .
welgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgd........................desrevihyhylp

WLDSCGVD-MNDIIKLHKVKNsllfnpqsfitslekdvckpdliddnnS---ElhldtANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNHSnkidv
| | .  | .........  .                           .   |      .. |.|||||||.||||.|.... .|. |  . . |     
wpdhgvpdllellldflefvr...........................kalae.....dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs.....

wnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
       .. .| |||.||  .||.. ||. .|||||...
.......leeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 406-738 5.4e-48 159.0 In-house 8-242 (243) alignment 
Range on Protein: 406-738
Range on HMM: 8-242/243.0
IQSFTKNRYSNILPYEHSRVKLphspkppavseasttetktdksypmcpvdaknhscKPNDYINANYLKLTqinPdfKYIATQAPLPSTMDD----FWKV
... .|||||.||||.||||||                                   ...||||||. . |   |  ..||||.|||.| .|    ||. 
penlsknrysdilpydhsrvkl...................................egsdyinanliyvt...p..rliatqgPlpetveddlasfwrm

ITLNKVKVIISLNSDDELNLRKWDIYWNnLSYSNHTIKLQNTWENICniNGCVLRVFQVKktapqndnisqdcdlphngdltsitM--AVSEPFIVYQLQ
.  ....||..|....||.  |.. ||.  ..  .... ... |. .  .....|.....                         .  .  ... |....
lwelgitvivmltelvElgrekcaqywp.gevtygdftvtllseehl..ddytvrtllle.........................nldlddltrlvihyh

YKNWLDSCGVD-MNDIIKLHKVKNSLLFNPQSFItslekdvckpdliddnnselhlDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttnH-Snkid
| .| | .  | ..|......  .. . .  |..                         ...|.|||||||.||||...... .|. |     . .    
ylpwpdhgvPdspedlldfldevrefieellsll......................aldsggpvlVHCsaGvgRtGtliaaylmllll.....gvd....

vwnmtqdlIFIIVNELRKQRIS-MVQNLTQYIACYEALLNYF
        .. .|..||.||   .||.. ||. .||||| ..
........leeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 406-738 3.2e-37 123.1 In-house 26-268 (274) alignment 
Range on Protein: 406-738
Range on HMM: 26-268/274.0
IQSFTKNRYSNILPYEHSRVKL-PHSPKppavseasttetktdksypmcpvdaknhsCKPNDYINANYLKLTQINPDfKYIATQAPLPSTMDDFWKVITL
  | ||||| .||| |.||| | ..|..                              .  .||||||.|  . .    |.||| |||.|..|||..|  
fgsqtknryktilPnensrvllesesse.............................dedssyinanyikGydeesk.ayvatqGPlpntvadfWrmiyq

NKVKVIISLNSDDELNLRKWDIYWNNLS-Y--SNHTIKLQNTWENICNINGCVLRVFQVKKTAPQNDnisqdcdlphngdltsitmavsepfiVYQLQYK
..|.||. |    | | .|   |. .   |  |.. .... . |.| . |.  .| . .|..  ...                          |.   | 
eevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers..........................vkhywyt

NWLDSCGVD-MNDIIKLHK-VknsllfnpqsfitslekdvckpdliddnNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPttnhsnkidvw
.| |    | .| ...| . |                            ... . ..|. .| .|||||| ||||.|.. .  .  |             
dWPdhksPddantlldlvlev............................eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre...........

NMTQDlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
... | .. || .|| .|  |||.  ||   ..||  | 
eivvd.vlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 406-568 3e-15 51.0 In-house 43-171 (287) alignment 
Range on Protein: 406-568
Range on HMM: 43-171/287.0
IQ--SFTKNRYSNILPYEHSRVKLPhspkppavseasttetktdksypmcpvdaknhsCKPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVIT
|      |||...||...  || |                                   . .||||| ...    . . ..|....|. .|. .|||.| 
iasqnkdknRltqilvpdnyrvllk.................................gehpdyinavfid..gykekkafiiaesPmfntarnfWklid

LNKVKVIISLNSDDELNLRKWDIYWNNLS---YSNHTIKLQNtwENicNINGCVLRVFQVKKTAPQND
 ..|..|. |  . | . ..   || . .   . ...|.| |  |.    .|.. | ..||..  ..|
drnvtaivmlcqekendeevcyqyWpeeksvvlGeynielln..ee..vnagyierklevknknkagd
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 406-607 1.1e-06 22.9 In-house 41-185 (288) alignment 
Range on Protein: 406-607
Range on HMM: 41-185/288.0
IQSFTKNRYSNILPYEHSRVKLPhspkppavseasttetktdksypmcpvdaknhsCKPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLN
|.. |..|| |.   . .||||                                    |. ||.|| .     . . . | .|||| .|.. .||..  .
ianptrdryenlprcditrvkls.................................ddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmlles

KVKVIISLNSDDELNLRKWDIYWNNLSysNHTIKLQNTwenicningcvlrvfqV---KKTApqnDNISQDCDLphngDLTSITMAVSEPFIVYQLQYKN
 |. |. |.   |. ..| . |.       ......                      ||     ..| .   .     |  |.  . |. || .| ...
dveyivmlcellekGkeksaeyfPskl..Gekarigrl................ctvvkkkr...adidklvkv....sllriskegeekvivkilhlle

WLDSC
| | .
Wdddg
0041856 (Phosphotyrosine protein) phosphatases II 408-741 9.1e-32 105.5 In-house 1-174 (182) alignment 
Range on Protein: 408-741
Range on HMM: 1-174/182.0
SFTKNRYSNILPYEHSRvklphspkppavseasttetktdksypmcpvdaknhsckPNDYINANYLKLTQINPDfkYIATQAPLPSTMDDFWKVITLNKV
...|||||.||||.|||                                       ..||||||..   . . .  .||||.||.||. ||.. .  ...
nldknrysdilpydhsr.......................................dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgi

KVIISLNsddelnlrkWDIYWNNLSysnhtiklqntwenicningcvlrvfqvkktapqndnisqdcdlphngdltsitmavsePFIVYQLQYKNWLDSC
..|..|.          . || .|                                                            .  ..|..| .| | .
ttivnlt.........eelywpell...........................................................erlgiqylylpwpDhg

GVDMNDIIKLHKVKNSllfnpqsfitslekdvckpdliddnnselhldtaNSSPLLVHCSAGCGRTGVFVTLDFLLSIlspttnhsnKIDvwnmtqdlIF
  |....... .  ..                                  .. | |||||||.||||..| ......          ...        ..
vpdldelldfieevle..................................eggpvlVHCsaGvgRtgtlvaaylmkkl.........gvs........le

IIVNELRKQRISMVQNLTQYIACYEALLNYFALQ
 .|...|..|  ||... ||. .. ||| .. |.
eavklvrsrRpgmvitpnqyfflqlallellllk
Y_phosphatase Protein-tyrosine phosphatase 409-736 2.5e-73 241.8 Pfam-A 2-235 (235) alignment 
Range on Protein: 409-736
Range on HMM: 2-235/235.0
FTKNRYSNILPYEHSRVKLphspkppavseasttetktdksypmcpvdakNHSCKPNDYINANYLKLTQiNpDFKYIATQAPLPSTMDDFWKVITLNKVK
..||||..||||...||||                               ..|..|.|||||||.|... . ..|.||||.||.||..|||.... .|||
kkknRykdilpydktrvkl...............................kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvk

VIISLNSDDELNLRKWDIYWN---NLSYSNHTIKLQNTwENICNIN-GCVLRVFQVKKTAPQNdnisqdcdlphngdltsitmavsEPFIVYQLQYKNWL
||. |.|..| . .|.. ||.   . |.....||.... |...... ...||....||.. ..                       |...|.||.|.|| 
vivmltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkees.......................ekrevkqlhytnWp

DSCgvdmndiikLHKVKNSLLfnpqSFITSLEKDVckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPtT-NhsnkIDVWNmtq
|..         . . ..|||    ..|...||.                 .|.|.|..||||||.||||.||.||.||. |.  . .    .||..   
dhg.........vpespksll....dlirkveksk................eaksgpvvVhCsaGvgRtgtfvaldilleqlea.eee....vdvlq...

dlifiIVNELRKQRISMVQNLTQYIACYEALLN
     ||.||||||..|||.|.|||..|.|.|.
.....ivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 409-736 2.5e-73 241.8 In-house 2-235 (235) alignment 
Range on Protein: 409-736
Range on HMM: 2-235/235.0
FTKNRYSNILPYEHSRVKLphspkppavseasttetktdksypmcpvdakNHSCKPNDYINANYLKLTQiNpDFKYIATQAPLPSTMDDFWKVITLNKVK
..||||..||||...||||                               ..|..|.|||||||.|... . ..|.||||.||.||..|||.... .|||
kkknRykdilpydktrvkl...............................kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvk

VIISLNSDDELNLRKWDIYWN---NLSYSNHTIKLQNTwENICNIN-GCVLRVFQVKKTAPQNdnisqdcdlphngdltsitmavsEPFIVYQLQYKNWL
||. |.|..| . .|.. ||.   . |.....||.... |...... ...||....||.. ..                       |...|.||.|.|| 
vivmltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkees.......................ekrevkqlhytnWp

DSCgvdmndiikLHKVKNSLLfnpqSFITSLEKDVckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPtT-NhsnkIDVWNmtq
|..         . . ..|||    ..|...||.                 .|.|.|..||||||.||||.||.||.||. |.  . .    .||..   
dhg.........vpespksll....dlirkveksk................eaksgpvvVhCsaGvgRtgtfvaldilleqlea.eee....vdvlq...

dlifiIVNELRKQRISMVQNLTQYIACYEALLN
     ||.||||||..|||.|.|||..|.|.|.
.....ivkelRkqRpgmvqsleqYiflykaile
0049772 (Phosphotyrosine protein) phosphatases II 409-741 7.2e-27 90.3 In-house 47-283 (314) alignment 
Range on Protein: 409-741
Range on HMM: 47-283/314.0
FTKNRYSNILPYEhSRVKLPHSPKppavseasttetktdksypmcpvdaknhscKPNDYINANYLKLTqinpdFKYIATQAPLPSTMDDF----------
 .|||| .|||.. .||.||  |                               .  |||||.|..        |.||||.||. |..||          
rdknryldilpad.nrvilpglpv..............................sgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyng

WKVI--TLNKVKVIIS---------------------LNSDDELNlrkwdiywnnlsysnhtiklqntwenI----------Cningcvlrvfqvkktap
|...    ..| .|                       |.. |...                                     .                 
wrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng..........................neptaadlellk.................

qndnisqdcdlphngdlT-------SitmavsePFIVYQLQYKNWLDSCGVDMNDIIKLHKVKNSLlfNpqsfitslekdvckpdliddnnselhldtaN
                 .               .  .... . .. | .  . .|. .. .. ...  .                              .
.................eelydpelf.......erlgikylripvpDgsaplledfdeflefieea..d..............................k

SSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnhsnkidvwnMTQDLIfiiVNELRKQRI-----SMVQNLTQYIACYEALLNYFALQ
 .|.||||.||.||||.||....|.. |              .. . .   ....|..|      .....| ||. ..||||.|.  .
ggpvlvHCkaGkgRtgtfvvaaylmkllg.............vsleea...ledvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 409-572 3.4e-21 70.6 In-house 42-174 (281) alignment 
Range on Protein: 409-572
Range on HMM: 42-174/281.0
FTKNRYSNILPYEHSRVKLPHSPKPPavseasttetktdksypmcpvdaknhsckPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVK
 .|||||||  |...|||. .. .                                .||||||...   .. . .|||||.|.|.....||...  .||.
vlknrYsnivaYDatrvkvtpneenk.............................ntDYinanfvp..gykgekeyiatqgPvPaslvafWqmvweqkvs

VIISLNSDDELNLRKWDIYWNNLS----YSNHTIKLQNTweniCNINGCVLRVFQVKKTAPQNDNISQ
.|. .  . | .  |   || . .    |.. |.| ...     . .  . |.|.....  .. ...|
aivmvtreieagklkChrYWPddnselkygdvtvkstae....eekatyierkfkleresgetreveq
subfamily_PTPN23_pd Subfamily PTPN23 410-563 3.8e-19 63.6 In-house 45-165 (288) alignment 
Range on Protein: 410-563
Range on HMM: 45-165/288.0
TKNRYSNILPYEHSRVKLPhspkppavseasttetktdksypmcpvdaknhsCKPNDYINANYLK-LTQINPDFkyIATQAPLPSTMDDFWKVITLNKVK
.|||. .||||.|.||||                                   . .||||| ..| |.   |||  |||||||.||. |||...  .|..
eknrsrdilPyDhnRvklr.................................gskDDYinAsfvkdlspgcPdf..iatqaPlqstlnDFWlmvyeqkss

VIISLNSDDELNLRKWDIYWNN-LSYSNHTIKLQNTWENICNINGCVLRVFQVKKT
||. | | .||.  | | || .    ...  .|. | ..  . . .| ||....  
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletl
subfamily_egg_pd Subfamily egg 410-530 2.8e-10 34.4 In-house 42-129 (307) alignment 
Range on Protein: 410-530
Range on HMM: 42-129/307.0
TKNRYSNILPYEHSRVKLphspkppavseasttE-------TktdksypmcpvdaknhsckpnDYINANYLKLTQINPDFkyIATQAPLPSTMDDFWKVI
.| |   .   . |||||               |                             |.| ||..|   .  .|  | .||||  |.||||...
ekarskrvhckdssrvkl...............elrrGqyld.....................dfihanrvkGkpllnef..ilaqaplkntvddfwrmv

TLNKVKVIISLNSDDELnlRKWDIYWNN
  ..|. |. |.|  |    . . || .
fqeevqyivmltsrkes..erceyywpk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 411-736 2.8e-21 70.6 In-house 36-264 (283) alignment 
Range on Protein: 411-736
Range on HMM: 36-264/283.0
KNRYSNILPYEHSRVKLPHSPKppavseasttetktdksypmcpvdaknhsckpnDYINANYLKLTQ-INPDFKYIATQAPLPSTMDDFWKVITLNKVKV
|||. .|.|..  ||.|   ..                                 ||||| .. ...  . | |||..|.||  |. ||||..  .|.  
knrnqeivpadqwrvelksesr.................................dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

IISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTWENicniNGCVLRVFQVKKTapqndnisqdcdlphngdltsitmavsepfivyqlqyknwlds
|. |    | .  |   || .     | . |. |.. . .    |  . . . ...                                            
ivmltklqedlrikCsqyWPkrGsedyGeftvtlrketts....nsfiikelllrvn...........................................

CGVDMNDIIKLHKVKNSLLFNPQSFITSLekdvCKPDLIDDNNSElhldtANSSPLLVHCSAGCGRTGVFVTLdfLLSILSPTTnhSNKIDvwnmtqdlI
.    . ..  ..| . | ...|. | ||     | ...  .  |      . .|..||||.| |||.||...    |.    |  .  .|        .
ssakstlllahyqvidWleygeqaiinsl....vkfnkvislqte.....skkgPivvhCstgiGrtavfiaa..sasvkdalt..esvvd........v

FIIVNELRKQRISMVQNLTQYIACYEALLN
| .|. .|.||. .||.| ||   .|. |.
favvkimreqrmmavqtldqyklvhelvle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 411-531 1.1e-11 39.5 In-house 6-94 (237) alignment 
Range on Protein: 411-531
Range on HMM: 6-94/237.0
KNRYSNILPYEHSRVKLPHSPKPpavseasttetktdksypmcpvdaknhsckpNDYINANYLKLTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVI
||||.||  |.|||| |  .                                   |||||.|||  .  |  ||||.| || |. ||||...  .|  ||
knrygnivaydhsrvvlkgagsg...............................sdyinatylkgfdgtpk.kyiaaqgplesscddfwqmvwqekcsvi

ISLNSDDELNLRKWDIYWNNL
. |    | |  |   || . 
vmltgliegnelkchkywpst
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 445-541 1.6e-11 38.7 In-house 60-153 (315) alignment 
Range on Protein: 445-541
Range on HMM: 60-153/315.0
KTDKSYPMCPVDAK-NHSckpnDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN--NLSYSNHTIKLQ
 .||| .  |.  . .||    ||.|||...    |   .|||.|.|......|||...  ...  |. |..  | . || . ||   .. | . |. ..
aydksrvqlpllendphs....dyvnanfid..GynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrk
subfamily_PTPN13_pd Subfamily PTPN13 452-564 1.7e-15 52.0 In-house 46-161 (273) alignment 
Range on Protein: 452-564
Range on HMM: 46-161/273.0
MCPVDAKNHSCKPND-YINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSysNHTIKLQN----TWEN
. |.|.     . .  ||||...|..  .  ..|||.| ||| |..|||...   |..||. . .. | .  | . || .    |...|..|    . ..
vlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk..nkklkvsnrlevellk

ICNINGCVLRVFQVKKTA
. . .| |.| ..||...
vqkldgfvvralavkdse
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 454-513 8.3e-10 32.7 In-house 58-116 (347) alignment 
Range on Protein: 454-513
Range on HMM: 58-116/347.0
PVDAKNHS-CKPNDYINANYLKLTqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISL
| ..||    ... |||| ..|.   | . .|| || |||.|. ||||.... ||  ....
peksknsraddvetyinashikfd..naskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_CG42327_pd Subfamily CG42327 455-530 1.1e-08 29.2 In-house 46-120 (319) alignment 
Range on Protein: 455-530
Range on HMM: 46-120/319.0
VDAKNHSCKPNDYINANYLKLTQINPdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN
|  .  . . . |..|.|..  .  |   |||.|..| ..  |||...  .. .||. | .  || ...   |.  
vlqrigdddkdeyldasyvrGyddap.nsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 457-605 5.9e-13 43.2 In-house 62-200 (301) alignment 
Range on Protein: 457-605
Range on HMM: 62-200/301.0
AKNHSCKPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL-SYSNHTIKLQNTWENICNINGCVL
 .| . . ..||||.|..   ..   |.||.|.|. .|. |||..|  .|.  |. .   .|    |   ||.|    |..  ....|  | ...   |.
kpnldlcqreyinasyid..gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvi

RVFQVKKTAPQNdnisqdcdlphNGDLTSITMAVS--EPFIVYQLQYKNWLD
| ..|| .   |           || . .     |  ..  | |||  .| .
rqlnvkiqdgsn...........ngyierkfkvksdksswdvlqlqvtdWpq
subfamily_PTPN6_pd Subfamily PTPN6 458-605 7.3e-16 53.0 In-house 74-198 (306) alignment 
Range on Protein: 458-605
Range on HMM: 74-198/306.0
KNHSCKPNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHT--IKLQNTWEniCNINGCVL
|..| . .|||||||.|  . . | .|||||  |..|. |||...  .. .||. .  . | .  |   || . . ....  |...|. |   . .  .|
kepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse..ksladYil

RVFQVKKTapqndnisqdcdlphngdltsitMAVSEPFIVYQLQYKNWLD
| ..|.|.                          .|   |.|...|.| |
Relsvskk.......................kkkkeerevfqyhfksWPd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 458-543 9.4e-13 42.9 In-house 30-115 (250) alignment 
Range on Protein: 458-543
Range on HMM: 30-115/250.0
KNHSCKPNDYINANYLKLTQINpdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRkWDIYWN---NLSYSNHTIKLQNT
|... |  ||||| .|.  . .    .||||.||..|. |||.... .|...|. |..  | .   .  ||       | . |..| ..
kekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllsk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 458-525 2.9e-08 27.8 In-house 66-131 (305) alignment 
Range on Protein: 458-525
Range on HMM: 66-131/305.0
KNHSCKPNDYINANYLKlTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWD
| ..  | .|| |||.  |  ||  ..| |||||  |  ||| .   .||. |. |    |   .|  
klegpwpheyihanyvs.tptnpk.rfictqaplektcadfwymclqdkveaifmlcnllekgakkcl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 458-529 4.4e-08 27.4 In-house 55-122 (285) alignment 
Range on Protein: 458-529
Range on HMM: 55-122/285.0
KNHSckpNDYINANYLKLTQINpDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN
|||     ||| |.....   . .  ||.|| ||| |. |||..|  .|.  .. | .  |  . |  .|. 
knhd...rdyihaswmrmpgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 459-560 3.7e-15 51.0 In-house 78-179 (298) alignment 
Range on Protein: 459-560
Range on HMM: 78-179/298.0
NHSCKPNDYINANYLKLTQINPdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTwENICNINGCVL
... .  ||||| .|.  . ..   .|||||||..|. |||...| .....|. |..  ||.  |.  || .     | . |..|... |.  ..  . |
edadeesdYiNAsflhaykgrn..afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllsk.eefadlivrkl

RVFQV
 | . 
kvskk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 459-564 2.1e-14 48.4 In-house 68-172 (305) alignment 
Range on Protein: 459-564
Range on HMM: 68-172/305.0
NHSCKPNDYINANYLKLTqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYS-NHTIKLQNTWENICNINGCVLRV
..| . .|||||.|..    .   |||..|.||..|..|||..|   ||..|. |    | .  |   || .     ..  ... . ..  .... . | 
keslddsdyinasyvdgy..krkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRk

FQVKKTA
... .  
lkisied
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 460-563 1.8e-13 45.2 In-house 70-171 (288) alignment 
Range on Protein: 460-563
Range on HMM: 70-171/288.0
HSCKPNDYINANYLKLTQINpdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLS----YSNHTIKLQNTweniCNINGCVL
.  . .|||||.|.. .. .   ||||||.||..|..|||...  ||.. |. |..  | . .| . || .      | . |..|...     . .  ||
eeeagaDYinasyidgekkk..kkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlves....keledfvl

RVFQVKKT
| . ..|.
rklllekk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 460-567 3.3e-13 44.2 In-house 71-175 (290) alignment 
Range on Protein: 460-567
Range on HMM: 71-175/290.0
H-SCkPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL---SYSNHTIKLQNtwENICNinGCVL
|  | .|.|||| |.|  . . . .|||||.|...|. ||||.|  .|| .|. | .  | .  |   || .    .| . .|||.|  |...|  . . 
hkDC.tneyinAcyik..gykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsiklln..eetln..eyie

RVFQVKKTAPQN
| ..||..  ..
rklevknknsag
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 460-548 1.6e-11 38.4 In-house 75-162 (305) alignment 
Range on Protein: 460-548
Range on HMM: 75-162/305.0
HSCKPNDYINANYLKLTQInPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENIC
.   | ||| |||.    | |. ..|..| ||  |.|.|| ..  |||. |. |    ||   |   ||      ....|     ||. 
dkpspsdyihanyvgcpmi.pekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvs
subfamily_PTPRN_pd Subfamily PTPRN 460-537 2.1e-10 34.8 In-house 79-155 (297) alignment 
Range on Protein: 460-537
Range on HMM: 79-155/297.0
HSCKPNDYINANYLklTQINPD-FKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHT
 | . .|||||  .  .. .|    |||||.||.||. |||...  . | ||..| . .| .... . || .   . . 
asaeksdyinasai..ldhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyh
subfamily_PTPN14_pd Subfamily PTPN14 461-738 1.7e-26 87.9 In-house 72-296 (300) alignment 
Range on Protein: 461-738
Range on HMM: 72-296/300.0
SCKPNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNtwenicningcvlrvFQV
  . ..||||  .| .    . .||..|.||. |. |||...  ..|..|. | .. |    |   |. .|. ...|.. ..               |.|
kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgk...............fkv

KKtapqndNISQDCDLPHNGDLTSITMAVSEPFIVYQLQYKNWLDS-CGVDMNDIIklhkvknsllfnpqsfiTSLEKdVckPDLIDDNNSELHLdTANS
 .      . |.| |      |.   .  .|   |. |||..| |  .  |... .                   ||. |    .    ||| .  . ..
tt......kfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgfl.................syLee.v..qsvrrktnseves.kesk

SPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYF
 |.||||||| ||||| .. |.|..    | .| ..||. ..        .. ||.|| ..||.|.||   |..|..|.
PPvlvhCsaGvGrtGvlilsdllia....tlehneeidikkv........larLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPN12_pd Subfamily PTPN12 461-563 1.5e-17 58.4 In-house 64-166 (290) alignment 
Range on Protein: 461-563
Range on HMM: 64-166/290.0
SCKPNDYINANYLKLTQinPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNH---TIKLQNTWENICNiNGCVLRV
. . .||||||..| ..   . .|||.|.||| |.||||..|   .|.... .    ||.  | . || .   ..    ....... |. .. .. ..| 
eeegsdYinanfikgve..gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavd.ddflirt

FQVKKT
..|.. 
Lkveaq
0044763 (Phosphotyrosine protein) phosphatases II 462-738 6.5e-17 57.2 In-house 10-171 (178) alignment 
Range on Protein: 462-738
Range on HMM: 10-171/178.0
CKPNDYINANYLKLTQINPDfKYIATQAPlpstmDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYsnhtiklqntwenicningcvlrvfqvk
... ..  . |. ...| |.  |.... |      |... .  .....|..|....||.  | | ||                                 
snleglersdyinaseilpg.lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............................

ktapqndnisqdcdlphngdltsitmavsepfivYQLQYKNWLDSCGVD-MNDIIKLHKVKNSLLfnpqsfitslekdvckpdliddnnselhldTANSS
                                  .| .. .. |..  | .  . ....  ...|                                . .
..................................iqylhipipDhgvpdllehflefvefieeal..............................dekgg

PLLVHCSAGCGRTGVFVTLDFLLSIlspttnhsnKIDVWNmtqdlifiIVNELRKQRIsMVQNLTQYIACYEALLNYF
| ||||||| ||.|..| .. ...          .... .        .....|..|  .|.|  |.  .||  | ..
pvlVHCsaGvgRsgtlvaaylmkkl.........glslee........aielvrerRp.ivpnpgqlrqLyefelrll
subfamily_PTPRB_pd Subfamily PTPRB 462-563 2.1e-15 51.5 In-house 76-175 (293) alignment 
Range on Protein: 462-563
Range on HMM: 76-175/293.0
CKPNDYINANYLKLTQINpdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVFQVK
 . .|||||||..  . .   ..|||| |||.|.||||...  .|...|. |    |    | . || . . .    ... |  .  . .  |.| ....
esgsDYinanyipgynsp..refiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkie

KT
|.
ke
subfamily_PTPN9_pd Subfamily PTPN9 462-562 7.3e-11 36.6 In-house 67-166 (297) alignment 
Range on Protein: 462-562
Range on HMM: 67-166/297.0
CKPNDYINANYLKLTQINPdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN-NLSYSNHTIKLQNTWENICNINGCVLRVFQV
 .  ||||||..   . .    .|||| ||. |..|||...  ..| ||.      |   .|   ||. .   |..  .|. .  .. . .  . ||...
deasdyinanfvdGykqkk..afiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvlei

KK
|.
kn
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 462-525 2.9e-08 27.7 In-house 66-126 (303) alignment 
Range on Protein: 462-525
Range on HMM: 66-126/303.0
CKPNDYINANYLKLtqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWD
     || |.||.|   . . | | || ||. |  |||..|  .|||... | .| | .    |
lsdssyihasylel...dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggd
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 462-567 4.6e-08 27.0 In-house 76-181 (310) alignment 
Range on Protein: 462-567
Range on HMM: 76-181/310.0
CKPNDYINANYLKLTQINPDFkyIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSN--HTIKLQNTWENICNINGCVLRVFQ
 . .||| |||.|   .   |  | .| ||  |. |||..|  .. . |. |    |    |   ||  |  ..    |.. |  |   ... | | |  
sryedyihanyvktnylrstf..icsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtf

VKKTAPQN
|    | .
vpdnvpvd
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 462-516 1.8e-06 22.1 In-house 54-106 (267) alignment 
Range on Protein: 462-516
Range on HMM: 54-106/267.0
CKPNDYINANYLKLTQINpdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSD
 | ..|||| |..  . .   ..|.|| ||  |. ||..||. .|| ||. |   
tkeeeyinasyvegyktk..nafivtqdplkntitdfltvihdqkvpvivlltkv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 462-519 2.1e-06 21.5 In-house 119-174 (244) alignment 
Range on Protein: 462-519
Range on HMM: 119-174/244.0
CKPNDYINANYLKLtqINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDEL
.  | |||| ..    .    .|| || ||  |  ||||..   .|.|.. | | .| 
smgntyinasfvgc..lgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee
subfamily_eak_pd Subfamily eak 462-532 8.1e-06 19.4 In-house 75-143 (332) alignment 
Range on Protein: 462-532
Range on HMM: 75-143/332.0
CKPNDYINANYLKLTQINPdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLS
  .. ||||  ......    ||| | ..  . .  ||...  .|   |. |  | ||.| | | |. . .
lnrlGyinaslaefsevGr..kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 463-568 2.1e-17 58.2 In-house 72-174 (318) alignment 
Range on Protein: 463-568
Range on HMM: 72-174/318.0
KPNDYINANYLKLTqiNPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSySNHTIKLQNTWENICNINGCVLRVFQVKK
.  |||||||.     . . .|||.||||| |..|||...   . .||. |    |   .| . || .   |..  ||. . ..  ...  ||| |.|..
egsDyinanyidGy..rrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtr

TAPQND
|  .. 
teeees
subfamily_PTPN3_pd Subfamily PTPN3 463-567 2.3e-14 48.0 In-house 63-169 (280) alignment 
Range on Protein: 463-567
Range on HMM: 63-169/280.0
KPNDYINANYLKLTQIN--PDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVFQV
 ..|||||||...         .||||| ||..|. |||...  .|...|. | .  |    |   || . . . .  ... . |.  . . .||| . .
setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvl

KKTAPQN
|... ..
kdketke
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 463-563 1.7e-12 42.1 In-house 74-171 (319) alignment 
Range on Protein: 463-563
Range on HMM: 74-171/319.0
KPNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTiKLQNTWENICNINGCVLRVFQVKK
.  |||||...     .   |.|||||||  |..|||...  ... ... |. . |    |   ||..  . .   .|  | |.  . .. . | ....|
egsdyinasfid..gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyG.rlivtleeeeeledyiirklklnk

T
 
k
subfamily_PTPRA_pd Subfamily PTPRA 463-561 9.9e-10 32.8 In-house 84-179 (330) alignment 
Range on Protein: 463-561
Range on HMM: 84-179/330.0
KPNDYINANYLKLTQinPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTWEnicnINGCVLRVFQ
.  ||||| ...  .     |.||.| |.  |..|||..|   |   |. |   .| .  |   || .   ..| | ....... .    ..   .| | 
eesdyinasfidGyk..ekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetv....lvdytvrkfl

VK
|.
vq
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 463-520 6.7e-06 20.4 In-house 11-66 (130) alignment 
Range on Protein: 463-520
Range on HMM: 11-66/130.0
KPNDYINANYLKLTQINpdFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELN
. |.||||... |..     .|. ||.||  |  ||||..    | |.. | | .| .
qgntyinasfvGllgrt..aeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed
subfamily_PTPRD_pd Subfamily PTPRD 464-741 1.4e-39 131.2 In-house 75-284 (564) alignment 
Range on Protein: 464-741
Range on HMM: 75-284/564.0
PNDYINANYLKLTQinPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSySNHTIKLQNTWENICNINGCVLRVFQVKKT
  |||||....  .   . .|||||.||..|..|||. .. .....|. |..  | .  | . || . . . .  .|. | |.  ...  ..| |..||.
gsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkk

ApqndnisqdcdlphngdltsitmaVSEPFIVYQLQYKNWLDSCGVDM-NDIIKL-HKVKNSLLfnpqsfitslekdvckpdliddnnselhldtANSSP
                          ||   | | .. .| |..  .  .....| .||...                                  .. |
k........................ssesreVrqFhFtsWPdhgvpesatslLdlirkvralne...............................pdagP

LLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFALQ
..|||||| ||||.|...| .|  .    ......|....        |..|||||  |||. .||| ..||.|.. | .
ivVhCSaGVGRTGtfividamleri....keektvDiyqy........vkalrkqRnamVqteeQYiFiheailealacg
subfamily_Ptp69D_pd Subfamily Ptp69D 464-739 5.2e-29 96.3 In-house 75-287 (307) alignment 
Range on Protein: 464-739
Range on HMM: 75-287/307.0
PNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN-NLSYSNHTIKLQNTWENICniNGCVLRVFQVKK
  |||||...|    .  .|.|| |.|. .|..|||..|.  .|..|. |   .| | .| . ||  .       |  .   |. .  .  . | ..| |
dsdYinasfik..gykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekh..sdyiiReldvsk

TAPQNDNIsqdcdlphngdltsitmavSEPFIVYQLQYKNWLDSCGVD-MNDIIKLHKVK-NSLLFNpqsfitslekdvckpdliddnnselhldtanSS
.  .  ..                    .   | | .|..| ||   .  . ..|| .   .   .|                                |
kkeesgev...................edsrkvvqyhytgWkDskvPevargllklieqvrelykln...............................rs

PLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFA
|..|||||| ||.|.||.|| ||      ..  .|.|....        | .||.||  .||.| ||. .| |||.|  
PivvhCsaGvgrsgifvaldsllq....qlkaedkvdifet........vkdLrsqRnllvqsleqYvflyralldyss
0043147 (Phosphotyrosine protein) phosphatases II 464-732 3.6e-25 84.1 In-house 4-155 (172) alignment 
Range on Protein: 464-732
Range on HMM: 4-155/172.0
PNDYINANYLKLTQINPDfkYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDdelnlrkwdiywnnlsysnhtiklqntwenicningcvlrvfqvkkt
..|||||.||.|. | ..  .||||.||..|..|||. .  .....|..|..                                                
gsdyinasyldlyyipdr..fiatqgplrntladfwrmlkelgithivnltel...............................................

apqndnisqdcdlphngdltsITMAVSEPFIVYQLQYKNWLDSCGVDMNDIIKLHKVKNSLLF--NpqsfitslekdvckpdliddnnselhldtanSSP
                      . .  .   ..|..| .| | .  ... .... .  ..||   .                               . |
.....................lydpellerlgiqylylpwpDhgvpllellleflefidellalsp...............................ggp

LLVHCSAGCGRTGVFVTLDFLLsilspttnhsNKIdvwnmtqdLIFIIVNELRKQRISMVQNLTQYIACYE
 |||||||.||||..| .. .|           ..         .. .|...|..|  .|||  ||. .|.
vlVHCsaGvgRtgtlvaaylml..........lgl........sleeavalvrekRpgavqnpsqyrflyy
0046846 (Phosphotyrosine protein) phosphatases II 464-737 2.8e-22 74.8 In-house 11-172 (176) alignment 
Range on Protein: 464-737
Range on HMM: 11-172/176.0
PNDYINANYLKLTqinpdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNlsYSNHTIklqntwenicningcvlrvfqvkkt
. ||||||..         ..||||.|||.|. ||.. .  ........|... ||.  |.. ||.   . .. |                         
dldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.........................

apqndnisqdcdlphngdltsitmavsepfivyQLQYKNWLDSCGVDMNDIIKLHKVKNSLLfnpqsfitslekdvckpdliddnnselhldtANSSPLL
                                 | .. .| | .  |......| .  .. |                                .  | |
.................................qylhlpwpDhgvpdlelllellefireal...............................keggpvl

VHCSAGCGRTGVFVTLDFLLSilspttnhSNKIDVwnmtqdliFIIVNELRKQRI-SMVQNLTQYIACYEALLNY
||||||.||||..| .. | .        .. ..|        . .. ..|.||   .||.  ||  .||..| .
VHCsaGigRtgtlvaayllel........ekglsv........eealalvreqRplgavqtpeQyrflyefelll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 464-738 3.5e-17 56.9 In-house 72-236 (392) alignment 
Range on Protein: 464-738
Range on HMM: 72-236/392.0
PNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNlrkwdiywnnlsysnhtiklqntwenicningcvlrvfqvkkt
 .||.|| |..   .. .  |||.|.| ....||||...  ..|  |. ..  .| .                                           
dsdylnasyip..sfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........................................

apqndnisqdcdlphngdltsitmavsepfivyqlqyknwldscgvdmndiiklhKVKNSLLFNPQSFITSLEKDVCKPD-LIDDNNSELHLDTANSS-P
                                                       | ..        |    .||| |    .     |.. |  . . |
.......................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythp

LLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYF
|..||||| ||||| ...| ...     ....  .||.|        .| ..|..|  |||   ||   | |.|. .
liihcsagvgrtgvvisidsvva....hakktrmvdvfn........fvtnirrkrpymvqtkeqyafiygavledl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 464-544 1.3e-13 45.6 In-house 47-124 (270) alignment 
Range on Protein: 464-544
Range on HMM: 47-124/270.0
PNDYINANYLKLTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNlsYSNHTIKLQNTW
   ||||||..  . ..  ||||...|||.|. .||..|  .||. |. .    | . .| . || .   .....||..  
ataYinAnyvrGfdgekk.kYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa..epkekvkledgk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 464-563 1.5e-12 42.2 In-house 75-172 (325) alignment 
Range on Protein: 464-563
Range on HMM: 75-172/325.0
PNDYINANYLKlTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNlRKWDIYWNNL-SYSNHTIKLQNTWENICNINGCVLRVFQVKK
  |||||.||. .... |  ..|.||||..|..|.|...   .  |.. ||  |. .  .  .|| .  . | .   |.     | .|   | ||..||.
ssdyinasylr.ddkkkd.vflaaqaPltatindlWrlvldWrcsvvvvlneldlgk.drcavywpkemgksktfGglevklrtieeisdyvhrvldvkq

T
.
v
subfamily_PTPRK_pd Subfamily PTPRK 464-609 1.7e-12 41.8 In-house 70-188 (314) alignment 
Range on Protein: 464-609
Range on HMM: 70-188/314.0
PNDYINANYLKLTQinPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENicNINGCVLRVFQVKKt
 .|||||...   .     ..|.|| ||..|. |||...  ..   |. |.   |    |   || . .     ||..    .    .  | |.|.|.| 
ssdyinaalidsyk..rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvete..llaelvvrifrvek.

apqndnisqdcdlphngdltsITMAVSEPFIVYQLQYKNWLDScGV
                     .. ...|  .| |.|. .| |  .|
.....................largqeeirevrqfqflgWpdh.dv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 464-530 2.1e-12 41.5 In-house 58-124 (297) alignment 
Range on Protein: 464-530
Range on HMM: 58-124/297.0
PNDYINANYLKLTQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN
 .|||||.|. . . . |.||| .| || .|.||||.... . |.||. .    |    |   || .
erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps
subfamily_ptpA1_pd Subfamily ptpA1 464-586 3.5e-11 37.5 In-house 74-189 (418) alignment 
Range on Protein: 464-586
Range on HMM: 74-189/418.0
PNDYINANYLKLTQinPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNTWENICNINGCVLRVFQvkkt
 .|||||||.  .   |  ..|.|| ||| |. |||...  |....|. |. . |    | | || .    ..     |  | .   .  .. | |    
gsdyinanyidgay..pk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviq....

APQNDNISQDCDLPHNGDLTSIT
 |. . |...  |  .|.   ||
dpereiitrnirltfegetrdit
subfamily_PTPN1_pd Subfamily PTPN1 464-605 7.5e-11 36.3 In-house 55-174 (290) alignment 
Range on Protein: 464-605
Range on HMM: 55-174/290.0
PNDYINANYLKLTQINPdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYsNHTIKLQNTWENICNINGCVLRVFQVKKT
 ||||||. ..| ...   .|| || |||.|.| ||...  .| | .. ||   | .  |   || .    .....|..|  ..  |.  . . ..|.. 
dndyinaslveleeakr..syiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee.ekellledtklkvkliseerksyytvrll

APQNdnisqdcdlphngdltsitMAVSEPFIVYQLQYKNWLD
  .|                   .   |   ...  |  | |
elen...................lktqetreilhfhyttwpd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 464-571 2.2e-09 31.7 In-house 66-163 (307) alignment 
Range on Protein: 464-571
Range on HMM: 66-163/307.0
PNDYINANYLKlTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNLSYSNHTIKLQNtwenicniNGCVLRVFQVKKT
  ||| ||||  . |.|  |.|..| || .|. .|| ..  .||. .| |    ||   | . ||      . .   ..        |   .  . .|| 
asdyihanylg.iaikpk.kficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeap........ntisvanlgakkl

APQNDNIS
||..| | 
apdedlin
subfamily_CG7180_pd Subfamily CG7180 464-619 3.7e-08 27.4 In-house 69-208 (296) alignment 
Range on Protein: 464-619
Range on HMM: 69-208/296.0
PNDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLrKWDIYWNNLS---YSNHTIKLQNTwENICNIngcVLRVFQV
 .||||| |        . .|| |.||  .|.|.||...  .... .. |    . .  ..  || | |   | .  ... .. ..  |.   . | |..
ksdYinavyvd..sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveivee.kqyanl...kirtfkl

KKTapqndnisqdcdlphngdLT----SITMAVSEPFIVYQLQYKNWLD--SCGVDMNDIIKLHK
.|.                  .       .  . |  || ..|.. |    .. .  | .|.| .
tkk..................ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr
0051429 (Phosphotyrosine protein) phosphatases II 465-739 1e-29 99.5 In-house 4-226 (272) alignment 
Range on Protein: 465-739
Range on HMM: 4-226/272.0
NDYINANYLKLTqinpdFK------YIATQAPLPSTMDDFWKViTLNKVKVIISLNSDDELNLRKWDIYWN-----------NLSYSNHTIKLQNTWENI
..||||....       ..      ......||| | .|||.    ...|.|..| |..|..  |.| ||            .  ..   ..|  |.  .
sgyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

CNINGCVLRVFQVKKTAPqndnisqdcdlphngdltsitmaVSEPFIVYQLQYKNWLDSCGVD--MNDIIKLHkvknsllfnpqsfitslekdvckpdli
 . . ..||....... .                        .|.. |..|.| .|.| .  .  . ....|                            
ellldyilrellltllls.......................agearevmhlhytdwpdhgvpqeallellell...........................

ddnnselhLDtanSSPLLVHCSAGCGRTGVFVTLDFLLsilsPTTNHSNKIDVWNMTQDLIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
        ||   . |.|||||||..|||..| |. ||       ...  .| . .|   .. .|.|||.||  .||. .||. .|||||... 
........ld...ggpvlvHCsaGkdRTGtvvalllll....lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellr
0036282 (Phosphotyrosine protein) phosphatases II 465-732 1.6e-29 98.2 In-house 2-164 (174) alignment 
Range on Protein: 465-732
Range on HMM: 2-164/174.0
NDYINANYLKLTQINPdfKYIATQAPLPstmddFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNlsysnhtiklqntwenicningcvlrvfqvkkta
.|||||..|.|. |.|  ..||.|.||.     ||. .  ........|..  ||.| |.  ||.                                   
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................

pqndnisqdcdlphngdltsitMAVSEPFIVYQLQYKNWLDSCGVDMNDIIKLHKVKNSLLfnpqsfitslekdvckpdliddnnselhldtA--NSSPL
                      .  ..   ..|..| .| | .  |.. .... |  .. |                               .  .. |.
......................lredlerlgiqylylpwpDhgvpdlsillefvkfveeal...............................sedpggpv

LVHCSAGCGRTGVFVTLDFLLSILSPTTNHSnkidvwnmtqdliFIIVNELRKQRISMVQNLTQYIACYE
|||||||.||||..| .. .|  | ... .              . .| |||.||  |||.  ||. .|.
lVHCsaGvgRtGtlvaaylmlrglleslvda.............ldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPRG_pd Subfamily PTPRG 465-739 5.2e-26 86.0 In-house 76-288 (563) alignment 
Range on Protein: 465-739
Range on HMM: 76-288/563.0
NDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN---LSYSNHTIKLQNTWENICningCVLRVFQVK
 |||||||..    .   ..|||| ||..|.||||..|  ..|..|. .    | . || |.|| .   . | . ...|...   ..       | ...|
lDYinAnyid..GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlal....ytvrtlvik

KTAPQNDNIsqdcdlphngdltsitmaVSEPFIVYQLQYKNWLDsCGVDMNDIIKLHKVKNSllfnpqsfitslekdvckpdliddnnseLHLDTANSSP
..  .. .                     .   |.| .| .| | .||    . .|  || |                                 |.  |
nlklkkkkq..................cdteklvrqyhytkWPd.hgvPehslpvLifvkks............................saankaeaGP

LLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
..|||||| ||||... || ||  .    .. |...|..        ..  .| ||  .||.  |||  ..|||.  |
ivvHcsaGvgrtGtyivldtllkqi....qqenavnvfg........flkhiraqRnflvqteEqYiflhdalleaia
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 465-569 1.5e-14 48.8 In-house 79-177 (297) alignment 
Range on Protein: 465-569
Range on HMM: 79-177/297.0
NDYINANYLKLTQInpdfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLrKWDIYWNNLSYSNhTIKLQNTWENICNINGCVLRVFQVKKTA
 ||.|| ..|  .     ..|.|| | ..|..|||...  ..|..|. || |.| .  |   || . . ..   ..  . . . . .| . | ..|.| .
sDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgk

PQNDN
... .
akarr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 465-530 1.1e-11 39.1 In-house 72-135 (315) alignment 
Range on Protein: 465-530
Range on HMM: 72-135/315.0
NDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNN
.||||| |.|   .. |  |||.|.||....||||...  .||  |. ..  .| .  |   || .
sdyinasyik..svdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 465-531 4.7e-11 36.5 In-house 71-135 (515) alignment 
Range on Protein: 465-531
Range on HMM: 71-135/515.0
NDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL
.||.|| |..   .. |  |||.|.|.....||||...  ..|  |. ..   | .  |   || . 
sdyfnasyip..sfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 465-529 6.6e-11 36.5 In-house 65-127 (287) alignment 
Range on Protein: 465-529
Range on HMM: 65-127/287.0
NDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWN
 |||||||.     . | ..||.|.|...|. |||...  ... ..| .  . |    |   || 
sdyinanyva..sytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 465-565 7.7e-10 33.7 In-house 53-144 (284) alignment 
Range on Protein: 465-565
Range on HMM: 53-144/284.0
NDYINANYLKLTQINpDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNsddelnLRKWDIYWNN---LSYSNHTIKLQNTWENICningCVLRVFQVK
 ||||| ...  | . | |||||| ||. |..|||..|   ..  |. |         |   || .     . .  .|..   |        |.| ... 
sdyinasfitGyqrk.d.kyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee....yvvrdiels

KTAP
. . 
edgk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 465-565 9.6e-10 33.3 In-house 89-180 (319) alignment 
Range on Protein: 465-565
Range on HMM: 89-180/319.0
NDYINANYLKLTQInPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNsddelnLRKWDIYWNN---LSYSNHTIKLQNTWENICningCVLRVFQVK
 ||||| ...  |  .| ||||.| ||. |..|||..|   ..  |. |         |   || .     . .  .|..   |        |.| ... 
sdyinasfvtGyqr.kd.kyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae....yvvrdiels

KTAP
. . 
edgk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 465-543 2.4e-07 25.1 In-house 35-114 (239) alignment 
Range on Protein: 465-543
Range on HMM: 35-114/239.0
NDYINANYLKLTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL--SYSNHTIKLQNT
.|||||.||.  . .|   |||||  .  .  |||...  ..  ||. |    |   .|   || .    | |  . |..|
sdyinasylrdydgspk.ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrkt
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 465-543 2.5e-07 25.1 In-house 36-115 (239) alignment 
Range on Protein: 465-543
Range on HMM: 36-115/239.0
NDYINANYLKLTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL--SYSNHTIKLQNT
.|||||.||.  . .|   |||||  .  .  |||...  ..  ||. |    |   .|   || .    | |  . |..|
sdyinasylrdydgspk.ayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrkt
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 465-515 1.5e-06 21.9 In-house 76-124 (439) alignment 
Range on Protein: 465-515
Range on HMM: 76-124/439.0
NDYINANYLKltQINPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNS
  ||||||.|      |  |||||.|   | ||||...  .|.  |. |  
shyinanyik..Gyyddklyiatqgpkkettddfwrlviekktvtivmltn
0051082 (Phosphotyrosine protein) phosphatases II 466-734 9.7e-20 66.1 In-house 4-149 (151) alignment 
Range on Protein: 466-734
Range on HMM: 4-149/151.0
DYINANYLKLTqinpdfkYIATQAPLPstmdDFWKVITLNKVKVIISLNSDDELNlrKWDIYWNNLSysnhtiklqntwenicningcvlrvfqvkktap
||||..|.          ......||.    ||.. .  ...|.|..|.|..| .  ..  |...|.                                 
dyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qndnisqdcdlphngdltsitmavsepFIVYQLQYKNWLDSCgvdmndiiklhkvknsllfnpqsfitslekdvcKPDLIDDNNSELHLDTAN-SSPLLV
                           . |..... .| |                                    |...|  .. |.|  .. . |.||
...........................ievlhipildwpdpg.................................lplsfdavleflellldkkngpvlv

HCSAGCGRTGVFVTLDFLLsiLSpttnhsnkidvWNMTQdlifiIVNELRKQRISMVQNLTQYIACYEAL
|||||.||||..| |. .|  |            ... .     ...|.|..|  .||  .|.. .. ||
HCsaGkgRTGtlvalylml..lg...........vslee.....aleeyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 468-531 2.2e-08 28.2 In-house 78-139 (301) alignment 
Range on Protein: 468-531
Range on HMM: 78-139/301.0
INANYLKlTQINPDfKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWNNL
| ||... |. .|. ..||||.||..|..||| ...  .|. |. |    | . .| . |    
ihanwip.tsGhph.rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk
0049260 (Phosphotyrosine protein) phosphatases II 479-732 9.7e-22 72.7 In-house 6-144 (152) alignment 
Range on Protein: 479-732
Range on HMM: 6-144/152.0
NPDFKYIATQAPLPSTMDDFWKVITLNKVKVIISLNSDDELNLRKWDIYWnnlsysnhtiklqntwenicningcvlrvfqvkktapqndnisqdcdlph
.. |..||||.|.| |..|||. .  .....|..|....||.  |.. |.                                                  
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

ngdltsitmavsepfivyQLQYKNWLDSCGVDMNDIIKLHKVKNSL-LFNPQSfitslekdvckpdliddnnselhldtanssPLLVHCSAGCGRTGVFV
                  | .. .| |..  |. ....         . ...                               | |||||||.||||..|
..................qylhlpwpDhgvpdlsqlllflllfieklaldkgg..............................pvlVHCsaGvgRtgtlv

TLDFLLsilspttnhsnkidvwnmTQDLIFIIVNELRKQRISMVQNLTQYIACYE
 .. .|                   .  .. .|. .|..|  .|.|  |.. .||
aaylml..................lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 484-530 7.7e-06 19.5 In-house 238-281 (440) alignment 
Range on Protein: 484-530
Range on HMM: 238-281/440.0
YIATQAPLPSTMDDFWKVITLNKVKVIISLNsddELNLRKWDIYWNN
.|||| || ||. |||...   ..  || ||   .|| .   |||  
fiatqmpldstvldfwrlvhdyristiimln...qlndktcsiywpv
0048179 (Phosphotyrosine protein) phosphatases II 582-732 1.1e-12 43.4 In-house 48-139 (144) alignment 
Range on Protein: 582-732
Range on HMM: 48-139/144.0
LtsitmavsepfiVYQLQYKNWLDSCGVDM-NDIIKLHKVKNSLlfnpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLD
             ..|... .| | .  |. ...... .  ...                                ... | |||||||.||||..|...
e............giqylhlpwpDhgvpdllellleflefieea...............................leeggpvlVHCsaGvgRtgtlvaay

FLLsilspttnhsnkidVWNMTqdlIFIIVNELRKQRISMVQNLTQYIACYE
 ..              . ...   .. .....|..|  .|.|  |.. ..|
lmk..............klgls...leealalvrsrrpgavpnpgqlrfLle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 590-736 1.5e-11 38.7 In-house 161-293 (297) alignment 
Range on Protein: 590-736
Range on HMM: 161-293/297.0
SEPFIVYQLQYKNWLDSCGV-DMNDIIKLHKVKNSLLFNPQSFITSLEKDVCkpdLIDDNNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSp
||   |   |. .| |     |..|. ...    |       ... .|  ..   ..  .   |. .   . .|||||||| ||.|| |  | .|..|  
sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemfta...mvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklr.

ttnhSNKIdvWNmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLN
     ..|   .     .  |.. ||.||  .|| | |.  .|.| |.
....kkri..pd.....vaailsilreqrarlvqtleqfellydavlk
subfamily_PTPN3_pd Subfamily PTPN3 592-736 4.3e-15 50.4 In-house 170-273 (280) alignment 
Range on Protein: 592-736
Range on HMM: 170-273/280.0
PFIVYQLQYKNWLDSC-GVDMNDIIKLH-KVKNSLlfnpqsfitslekdvckpdliddnnselhldTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspt
   . |||| .| |..   | .|....  .|..                                 .....|..|||||| |||||...|.  |...   
erkilqlqylaWpdhgvPddsadflefvervrklr...............................sgkeePvvvhCsaGigrtGvlilletalali...

tNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLN
 ...... . .        || ..| || ..||. .||    ||.|.
.eaaepvypld........ivrtmrdqramlvqtasqykfvCeailk
0048076 (Phosphotyrosine protein) phosphatases II 594-736 6.5e-13 44.1 In-house 46-141 (145) alignment 
Range on Protein: 594-736
Range on HMM: 46-141/145.0
IVYQLQYKNWLDSCGVDM-NDIIKLHKVKNSLLFNpqsfitslekdvckpdliddnnselhldtanSSPLLVHCSAGCGRTGVFVTLDFLLSilspttnh
 ..|..| .| | .  |. ...... .  ...| .                                 | |||||||.||||..| .. .|.        
lgiqylylpwpDhgvpdllellleflefieealke...............................ggpvlVHCsaGvgRtgtlvaaylmll........

snkidvWNMTqdlIFIIVNELRKQRISMVQNLTQYIACYEALLN
       ...   .. .....|.||  .|.|  |.. .||..| 
......lgvs...leealelvrsqrpgavpnpgqlrflyefele
PTPc_DSPc_SM00012 595-735 3.9e-24 80.2 In-house 2-104 (105) alignment 
Range on Protein: 595-735
Range on HMM: 2-104/105.0
VYQLQYKNWLDSCGVD-MNDIIKL-HKVKNSLLFNPQsfitslekdvckpdliddnnselhldtanSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTnh
|....|..| | .  . ...|..| ..||..   . .                             |.|..||||||.||||.||.|| ||. |. .|  
vkhyhytgwpdhgvPeesdsilellravkknknkses.............................skpvvVhCsaGvgRtgtfvaldillqqleket..

snkidvwnmTQDLIFIIVNELRKQRISMVQNLTQYIACYEALL
         ... || ||.|||||| .|||...||. .|.|||
.........kevdifqivkelrkqRpgmvqteeqylflyrall
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 641-739 9.2e-07 22.9 In-house 191-277 (312) alignment 
Range on Protein: 641-739
Range on HMM: 191-277/312.0
KPDLIDDNNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlIFIIvneLRKQRISMVQNLTQYIACYEALLNYFA
 ||  |     |     .  |.. ||||| |||| .. .. ... |     |  | .| .     .|..   |||.|   |. . ||. .  ..|... 
mpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaal....rhprkqnvkd.....sfvl...lrkdrarsvrvfpqyvyalrcvlefly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 645-737 1.9e-10 34.6 In-house 115-193 (440) alignment 
Range on Protein: 645-737
Range on HMM: 115-193/440.0
IDDNNSElhLDTANSSPLLVHCSAGCGRTGVFVTLDfllSILSpTTNHSNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNY
|.| |     . | ..|||||||||.||||| ...|   |||   ...|..||        || ..| .|..|  |||   ||   .||.|. 
iqdvnes..qekagngpllvhcsagagrtgviiavd...silr.eakrsdqid........ifsfinsmrnnrpqmvqtpeqyafvheavleg
subfamily_CG42327_pd Subfamily CG42327 645-738 2.5e-08 28.0 In-house 233-315 (319) alignment 
Range on Protein: 645-738
Range on HMM: 233-315/319.0
IDDNNSELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSpTTNHSnkIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYF
|. | |       .  || |||| | ||||. .. |. .  |  ....|  .|. .        .|  .|..| | |..  ||   |  | .| 
ingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsle.eskrs..vdiPq........lvssvrrdrasavltkeqyefiykvlseya
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 648-738 1.4e-14 49.0 In-house 210-288 (325) alignment 
Range on Protein: 648-738
Range on HMM: 210-288/325.0
NNSELHLDTANSSPLLVHCSAGCGRTGVFVTLdflLSILSPTTNHSnKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYF
 .  .. .|  |.|.||||||| ||||||..|    |.|    ..| ..|        ||  |. |||.| |||.   ||| .|||| ...
vservtantkastpilvhcsaGvGrtGvfisl...ysalakviees.rvd........ifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 650-737 9.1e-17 56.3 In-house 215-290 (319) alignment 
Range on Protein: 650-737
Range on HMM: 215-290/319.0
SELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNY
. |.    .  ...||||||.|||||...|| ||. .    .. ...||.|.        |..||.||  .||.|.||  .| |||. 
rhltskenhranivvhcsaGvGrtGvyivldvlldrm....keekqvdvynf........vrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 650-737 2e-16 55.4 In-house 179-254 (284) alignment 
Range on Protein: 650-737
Range on HMM: 179-254/284.0
SELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNY
. |.    . ....||||||.|||||...|| ||. .    .. ...||.|.        |..||.|| ..||.|.||  .| |||. 
rhltskenhranivvhcsagvgrtgvyivldvlldrm....keekqvdvynf........vrdlrqqrntlvqdlvqykfiysallee
subfamily_PTPN6_pd Subfamily PTPN6 650-745 3.8e-15 50.7 In-house 218-304 (306) alignment 
Range on Protein: 650-745
Range on HMM: 218-304/306.0
SELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTtNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFALQKQIK
 . .| .|.. |..|||||| |||| |. .| ||.... .     .||. ..        |. .|.||  .||  .||   |.|. .|   .|...
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekk.gldadidiqkl........vksvreqrsglvqteqqykfvykaikkyietkkkle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 650-747 3.3e-11 37.5 In-house 201-286 (287) alignment 
Range on Protein: 650-747
Range on HMM: 201-286/287.0
SELHLDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNhsnkIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQIKNA
 ||  |...  ||.||...| ||.|.....  |.| |  . .    .|| .        .|  ||..| ..||   |.   ||||  |.  . |. .|
ielardasevGPlvvhddvGiGrsGillatlvlvsrledlGr....vdvaa........vvirlreyraalvqavvqlrllyealvtyyktnpqlyva
subfamily_PTPRB_pd Subfamily PTPRB 654-743 1.3e-17 58.8 In-house 213-290 (293) alignment 
Range on Protein: 654-743
Range on HMM: 213-290/293.0
LDTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPttnhSNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQ
 .||...|..|||||| ||||.|..|| ||. ..     .. .|        || || |||..| ..||. .|||  ....|...  ...
ektaskrPivvhCsaGvGRtGtfialdrllqaiee....edyvd........ifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_PTPN13_pd Subfamily PTPN13 654-737 6.2e-17 56.8 In-house 198-268 (273) alignment 
Range on Protein: 654-737
Range on HMM: 198-268/273.0
LDTaNSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTnhsnKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNY
|.| ...|..|||||| ||.|...|.| .| ...  .    ..|| .        ||..||.|| ..||   ||| .|.|.|. 
lqt.dagPivvhcsaGiGrsGtlitidvvlglierdk....efdvke........ivrklreqrqgvvqtkdqyifvykailev
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 654-739 6e-15 50.1 In-house 212-285 (297) alignment 
Range on Protein: 654-739
Range on HMM: 212-285/297.0
LDTANSSPLLVHCSAGCGRTGVFVTLDfllSILSpTTNHSNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
 .. ...||||||.|| |||||..|.|   |...   .. ...|        || .|. ||..|  .||   ||   |.|.|... 
fsqnaegPllvhclaGvGrtgvlltid...svva.eakrekevd........ifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 654-739 1.7e-14 48.4 In-house 207-280 (315) alignment 
Range on Protein: 654-739
Range on HMM: 207-280/315.0
LDTANSSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFA
 .|.. ....|||||| |||| |.||| .|       .  | |||.|.        .. .|..|| ||| . ||   |.|||. | 
hhtnsvgaivvhcsaGvGrtGtfitldavld....qaeaenaidvynf........itgvrqnrikmvqvaeqyqfiydalletfv
subfamily_PTPN12_pd Subfamily PTPN12 655-744 1.3e-19 65.1 In-house 203-283 (290) alignment 
Range on Protein: 655-744
Range on HMM: 203-283/290.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPtTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQI
 .....||.||||||.||||. ...|.  ..|    . ....||..        .| |||||| ..||   ||   |.|.....  . .|
qesedaPlvvhCsaGvGrtGtiiaidyvrellka.ekipeeldvfd........lvlelrkqraalvqtkeqyelvykavaelvqkelei
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 655-736 1.6e-17 58.5 In-house 208-277 (288) alignment 
Range on Protein: 655-736
Range on HMM: 208-277/288.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPttnhSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLN
..|.. |..|||||| ||||.|..|| |.  .      ...||| .        .|..||||| ..||.|.||. .||.||.
nqadtgpiivhCsaGvGrtgtFialdalidavee....edyiDvag........tvaklRkqRallvqtlkqYefiyevlls
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 655-740 3.2e-16 54.1 In-house 193-266 (270) alignment 
Range on Protein: 655-740
Range on HMM: 193-266/270.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFAL
......||||||||| ||||....||. . .|.    ...|.|| .        |..||||.|. .||   ||   |.|...|   
eldkaePllvHcsaGvgRtGtlialDiavrlLe....etkkvdvla........iieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 655-736 1.6e-12 41.6 In-house 208-277 (439) alignment 
Range on Protein: 655-736
Range on HMM: 208-277/439.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLN
|. .  |..|||||| ||||  ..||  |  |    .  ||.|.          ||. |||||  |||.| ||.  |.|.|.
dkeeygpvvvhcsagvGrtGtiialdialeql....klenkvdikg........ivkvlrkqrkqmvqalcqyvfiynavle
subfamily_CG7180_pd Subfamily CG7180 655-741 1.1e-09 32.3 In-house 219-293 (296) alignment 
Range on Protein: 655-741
Range on HMM: 219-293/296.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVwnmtqdliFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQ
.  . .|..|..| | .|.||....|  |  .    .. ...||        |  |  ||..|  .|.| ..|  .|. ||...  .
edpeegPvvvvssdGasRsGvylaidanlelv....ekeeevdv........FeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 655-739 9.8e-07 22.5 In-house 214-286 (302) alignment 
Range on Protein: 655-739
Range on HMM: 214-286/302.0
DTANSSPLLVHCSAGCGRTGVFVTLDFLLSILspTTNHSNKIDVwnmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
..  ......    |.|| |.|.||   .. |  ....  .|            ||. .|.|| ..|..|.||.  | ||| |. 
kikadentvivSknGaGRagafltlavavekl..qkgkepnike..........ivksiRsqRpravdslkQyvslyialllyik
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 656-741 1.2e-16 55.7 In-house 210-283 (318) alignment 
Range on Protein: 656-741
Range on HMM: 210-283/318.0
TANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFALQ
... .|..|||||| ||||||...| ||  .    .. . .||...        |..||.||  |||   ||. .|..||.. |  
ksgagpivvhCsaGvGrtGvfiavdilleri....kaealvDvfqt........vkqlreqrnlmvqtedqyefiydvllealasg
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 656-739 2e-15 51.7 In-house 172-243 (250) alignment 
Range on Protein: 656-739
Range on HMM: 172-243/250.0
TANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
 |...|..|.|||| ||.| |...| .|  |    ......||..        ... |||.|. .|. |.||. .||..|..  
qagnaPvivqCsaGvgrsGafiaidavlerl....kkekvvdvfk........vikvlrkdrphavesleqyvfvyeiilkald
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 656-739 3.7e-14 47.7 In-house 220-291 (298) alignment 
Range on Protein: 656-739
Range on HMM: 220-291/298.0
TANSSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFA
 |  .|..|.|||| ||.| |. .| .|       ......||...        |. |||.|. .||  .||. .||| |....
qagnkpvivqCsaGvgRsGtfiaidsvle....rvkkeqvvDvfqv........vkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 656-747 4.7e-07 23.7 In-house 197-278 (281) alignment 
Range on Protein: 656-747
Range on HMM: 197-278/281.0
TANSSPLLVHCSAGCGRTGVFVTLDFLLSILsptTNHsnkidvwnMTQDLIFIIVNELR-KQRISMVQNLTQYIACYEALLNYFALQKQIKNA
 | |.| ..||||| ||.| .....  |  .    .|        .|   |  ||  ||   | . || | ||.  .. ||..    ||| . 
rarstppvihcsagvgrsgtlmaveialqsi...hsh........ftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqitee
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 656-729 7.7e-07 23.6 In-house 169-230 (237) alignment 
Range on Protein: 656-729
Range on HMM: 169-230/237.0
TANSSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIA
 ..|.| ..||||| ||||.|. .| .|      ..  . .|..|         |  . ..|  ..|   ||. 
vsesgpwiihcsagvgrtgiflvidamlr....qakekkvvdiyny........vysieedrpyiiqtkdqyvf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 657-740 5.7e-17 56.7 In-house 214-285 (319) alignment 
Range on Protein: 657-740
Range on HMM: 214-285/319.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnHSNKIDVwnmtqdliFIIVNELRKQRISMVQNLTQYIACYEALLNYFAL
 .| |. |||||| |||| |..||  |  ..    . . .||        |..|..|| ||  |||.  ||. .|||||..   
tqsgPivvhCsaGvGRtGtfivldamlervk....eegvlDv........fstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_PTPRA_pd Subfamily PTPRA 657-739 1.5e-16 55.2 In-house 226-296 (330) alignment 
Range on Protein: 657-739
Range on HMM: 226-296/330.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
 ...|. |||||| |||| |..|| .|  .    .  .|.||..        .|..||.||  ||| . ||  .|..||.|. 
qsagpivvhcsaGvGrtGtfivldavlerv....kaerkvdvfe........fvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 657-740 2.4e-14 48.1 In-house 206-278 (281) alignment 
Range on Protein: 657-740
Range on HMM: 206-278/281.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFAL
 .  ||..||||| ||||....|| |.. ..   .. ...|| .        .|.||||.|  ||| ..||   | |.|...  
ktkaplvihCsaGvGrtGtyialDrlvkave...aeleeldvka........vvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 657-740 4.1e-12 40.6 In-house 208-279 (315) alignment 
Range on Protein: 657-740
Range on HMM: 208-279/315.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFAL
 .  .|||||||| |||||....|  ..      .... .||.|        .|..||..|. .||   .|   |.|.|...  
kkefsllvhcsaGvGrtGvvisidevva....qikrtrsvdvfn........fvknlrakrpylvqteeeyafiydavledllw
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 657-739 4e-10 34.2 In-house 207-278 (307) alignment 
Range on Protein: 657-739
Range on HMM: 207-278/307.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNhsnkidVWNMTQdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
 .  |..|||||| ||.|  |.. ..   .    |        .| .     .|.|||.||   .|.  ||.  .  ||.|| 
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGin......ckdmkk.....lveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_PTPN1_pd Subfamily PTPN1 657-736 2.3e-08 28.1 In-house 199-269 (290) alignment 
Range on Protein: 657-736
Range on HMM: 199-269/290.0
ANSSPLLVHCSAGCGRTGVFVTLDFLLSILSPTTNhSNKIDVwnmTQDLIfiivnELRKQRISMVQNLTQYIACYEALLN
 .  | ..||||| ||.| |. .| .|  .  . .  . .|.    . |.     ||||.|. ..|   |    | |.|.
sdvGpavihcsaGiGrsGtfclvdtclvliekkdd.lssvdi...kkvll.....elrkyrlGliqtadqlrfsylaile
subfamily_PTPN9_pd Subfamily PTPN9 658-742 5.1e-16 53.5 In-house 222-294 (297) alignment 
Range on Protein: 658-742
Range on HMM: 222-294/297.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNMtqdlifiiVNELRKQRISMVQNLTQYIACYEALLNYFALQK
.  |..|||||| |||| |.|||. || |    .. ...|| .         |. ||.||  ..|   ||  || |.|.|   .|
sgPPivvhcsaGiGrtGtfitldiclsrl....eevgtvdvvet........vkllrtqrafsiqtpeqyefcylavleyalelk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 658-739 6.5e-16 53.4 In-house 215-284 (305) alignment 
Range on Protein: 658-739
Range on HMM: 215-284/305.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
.  ||||||||| ||||||...|  |  |    .. . .||..        ....||..|. |||.| ||  ...|| ..  
kgvpllVhCsagvgRtGvfiavdialerl....kkEevvdvfe........vlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPRK_pd Subfamily PTPRK 658-736 1.2e-13 45.6 In-house 209-275 (314) alignment 
Range on Protein: 658-736
Range on HMM: 209-275/314.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLN
.  ...||||||.||||.|...| .| ..    .. . .||.|        .| .||.... ||.   ||. .|...|.
eaGrivvhCsaGaGrtGtfiaidivldmi....eregvvdvfn........avktlrsrkvnmveteeqykfiydvile
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 658-740 4.5e-11 37.2 In-house 191-259 (267) alignment 
Range on Protein: 658-740
Range on HMM: 191-259/267.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILspttNHSNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYfaL
 . ||.|.||.| ||.| |...|  |  .     . .  |        ||  . ..|.|||..|. . .|| ..| | .|   
gnrPlvvacsdGvGrsGtflvidsqlera....ktegvsd........ifdflrkirsqriglvdtkeryiyihellaey..a
subfamily_PTPN23_pd Subfamily PTPN23 658-737 9.9e-11 36.0 In-house 211-279 (288) alignment 
Range on Protein: 658-737
Range on HMM: 211-279/288.0
NSSPLLVHCSAGCGRTGVFVTLdflLSILSPTtNHSNKIDvwnmtqdLIFIIVNELRKQRISMVQNLTQYIACYEALLNY
   ||.|||||| ||||||  .    ...  . .. | .         |  .|. ||.||  |||. .|.  .||| |..
sktPlvvhCsaGvgRtgvfalv...yaavrel.ekgngll.......diiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 658-739 3e-09 31.0 In-house 215-284 (290) alignment 
Range on Protein: 658-739
Range on HMM: 215-284/290.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
 | |. |||||| |||| ||...  | ||     .  ..|. .        .|  ||. |.. ||  .||.|  |.||..  
asGpvvvhcsaGiGrtGtfvaievglqill....dGkeldlld........lvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 658-744 3.3e-09 30.9 In-house 218-293 (305) alignment 
Range on Protein: 658-744
Range on HMM: 218-293/305.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnHSNKIDvwnMTQDlifiIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQI
   |. |||||| ||||  | |...|  |       ..|.    |.     |.. .|.||   .|  .||.  .. .||||  .| .
skgpivvhcsagigrtgsvvmleyildqll....agqiie...dtdk....ilqkireqrnnsiqtdaqylfvhqvilnyfrkkkll
subfamily_PTPRN_pd Subfamily PTPRN 658-733 3.2e-08 27.6 In-house 223-287 (297) alignment 
Range on Protein: 658-733
Range on HMM: 223-287/297.0
NSSPLLVHCSAGCGRTGVFVTLDFLLSILSpttNHSNKIDVwnmtqdliFIIVNELRKQRISMVQNLTQYIACYEA
 |.|..||||.|.|||||.. .|..|. |    .  ..||.           .. || ||  .|.   |.  .. |
rscpivvhcsdGaGrtGvyilidlvlnrll...kGvkeidi........aatlehlrdqrpglvktkdqfefalta
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 658-731 6.9e-06 20.4 In-house 133-196 (198) alignment 
Range on Protein: 658-731
Range on HMM: 133-196/198.0
NSSPLLVHCSAGCGRTGVFVTLDFllSILSPTTNHSNKIDvwnmtqdLiFIIVNELRKQRISMVQNLTQYIACY
. .|..|||| | | |||||.||    . |    ..  .|       | | . . ||. |  ..  | .|   |
kdapvivhcsdgqgftgvfvaldi..gvrsheesktsvvd.......l.fevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 658-731 7e-06 20.3 In-house 134-197 (199) alignment 
Range on Protein: 658-731
Range on HMM: 134-197/199.0
NSSPLLVHCSAGCGRTGVFVTLDFllSILSPTTNHSNKIDvwnmtqdLiFIIVNELRKQRISMVQNLTQYIACY
. .|..|||| | | |||||.||    . |    ..  .|       | | . . ||. |  ..  | .|   |
kdapvivhcsdgqgftgvfvaldi..gvrsheesktsvvd.......l.fevakrlrqarcgiisslqhynfiy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 659-740 9.1e-10 33.0 In-house 211-280 (287) alignment 
Range on Protein: 659-740
Range on HMM: 211-280/287.0
SSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVwnmtqdliFIIVNELRKQRISMVQNLTQYIACYEALLNYFAL
 ....||||.. ||...|.  .  .      ..    |||        | .... | |.  .||  .||.  ....|.|   
ntsivvhCsdtvGrsamfcaaattin....kckteGviDv........fqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 659-739 1.2e-09 32.5 In-house 216-284 (290) alignment 
Range on Protein: 659-739
Range on HMM: 216-284/290.0
SSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
  ...||||.. ||..||....  .      ..    ||        .| .....| |.  .||   ||   .. .|.|. 
ntsivvHCSdtvgrsavfcaaattin....kcktegvid........vfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 659-743 2.3e-09 31.4 In-house 226-298 (301) alignment 
Range on Protein: 659-743
Range on HMM: 226-298/301.0
SSPLLVHCSAGCGRTGVFVTLdfllSILSPTTNHSNKIDVwnmtqdliFIIVNELRKQRISMVQNLTQYIACYEALLNYFALQKQ
 .|..||||.. .|.||....    ||          .||        | ... .|...  .|. | ||.  |...  |..|.. 
ggpvvVHCSdtVsrsGvYcsv....siglEQckaegVVdv........fqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 659-741 3.2e-09 30.8 In-house 221-292 (305) alignment 
Range on Protein: 659-741
Range on HMM: 221-292/305.0
SSPLLVHCSAGCGRTGVFVTLDFLLSILSpttnhSNKiDVWNMTQdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFALQ
  |..|||||| ||||  |.....|  ..      || ..  | .     .|. || ||   .||  ||.  .  .||||  .
kvpivvhcsagigrtgtivaieyilekia.....enk.pcppmpe.....lvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 659-739 1.9e-07 25.3 In-house 203-271 (285) alignment 
Range on Protein: 659-739
Range on HMM: 203-271/285.0
SSPLLVHCSAGCGRTGVFVTLDFLLSILSptTNhsNKIDvwnmtqdlIFIIVNELRKQRISMVQNLTQYIACYEALLNYFA
  |. |||||| |||  || .|.    .    |   .|.        .. || |.|  |.  ||.  |..  |  |..|| 
ekpicvhcsagvgrtatfvgidyatirim..en..pnie........mldivremramrfqavqshmqflflyvvlmeyfi
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 659-735 6.6e-07 23.7 In-house 173-237 (239) alignment 
Range on Protein: 659-735
Range on HMM: 173-237/239.0
SSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALL
. | ..||||| |||| |. .| .|      ... . .|..|         |. .|..|  |||   ||.  . |.|
arpwvihcsagvgrtgaflvidamlr....qakkqktvdifn........yvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 659-735 7.8e-07 23.5 In-house 174-238 (239) alignment 
Range on Protein: 659-735
Range on HMM: 174-238/239.0
SSPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALL
. | ..||||| |||| |. .| .|      ... . .|..|         |. .|..|  |||   ||.  . |.|
arpwvihcsagvgrtgaflvidamlr....qakkqktvdifn........yvkairedrphmvqtseqyvfihlavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 660-739 7.5e-12 39.1 In-house 210-277 (515) alignment 
Range on Protein: 660-739
Range on HMM: 210-277/515.0
SPLLVHCSAGCGRTGVFVTLDFLLSilspTTNHSNKIDVWNmtqdlifiIVNELRKQRISMVQNLTQYIACYEALLNYFA
 ||..||||| |||||....|  ..      . .. .||.|        .|. .|..|  .||   ||   |.|.|... 
hpliihcsaGvGrtGvvisidsvva....hakttrmvdvfn........fvtnirqkrpylvqtqeqyafiygavledll