Gene CDC14 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP005_AA protein Get Run
SpurP005_AA_7-156 phosphatase_domain Get Run
SpurP005_AA_175-333 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0048567 (Phosphotyrosine protein) phosphatases II 6-160 1.7e-53 175.0 In-house 3-157 (157) alignment
Range on Protein: 6-160
Range on HMM: 3-157/157.0
ELMSASEIIQDRLYFATLRNKPRSTTNTHYFCIDDEFQYENFYADFGPLNLALLYRYCCKLNKKLKSTSLSRKKIVHYTSFDSKKRTNAACLIGCYAVRY
|.....|||.||||||.|...|.|. |..||.|||...||.|..||||||||.|||...||||.||...| .|.|....... |||...|.|||||.. .
engdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilh

FHQTPNSSEISIYFVTADNLSIKDASFGACTYNLTLLDCLKGIDKAVTHGFLDFE
.. ||.     . .|  . .   |||.. ..|||||||.|.|. ||. .||||.|
lgftpeeaiaplrivrpgsvpfrdasyllslynltlldvlyGllkAlelgfldle

subfamily_CDC14_pd Subfamily CDC14 9-334 3.8e-174 573.1 In-house 2-328 (328) alignment
Range on Protein: 9-334
Range on HMM: 2-328/328.0
SASEIIQDRLYFATLRNKPRSTTNTHYFCIDDEFQYENFYADFGPLNLALLYRYCCKLNKKLKSTSLSRKKIVHYTSFDSKKRTNAACLIGCYAVRYFHQ
.|.|...|||||||||.||.||...|||..|||..|||||||||||||| |||||.||||||||.. ..||||.|||.|||||.|||.|||.||| |...
nalelledrlyfatlrkkPkstselhyfsvddelkyenfyadfGPlnlavlyrycvklnkkLkseekaskkivlytsadskkranaalligayaviylkk

TPNSSEISIYFVT-ADNLSIKDASFGACTYNLTLLDCLKGIDKAVTHGFLDFENFDVEEYEHYERVENGDFNWIVPNKYLAFSGPHPKSKIENGYPYHAP
|....  .. ... .......|||.|...|.|||||.|||..||...||||.|.||.||||.||||||||||||||.|.||..|||.|||.|.|||.|||
taeeayraleaaetppfvpfrdasygsasykltlldvlkgvekalqkgfldledfdleeYekyervenGDfnwivPdkflalagPhnkskledgyplhaP

EAYFPYFRKHNITSIVRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMR
|....||||.|.|..||||||.|||..||||||||.||||||||||||.|..|||.|.|..||..|||||||||||||||.||.|||.||||||.|||.|
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlr

ICRPGSVIGPQQHYMEEKQAAMWVQGD
||||||||||||...||||||.|..||
icrPGsvigpqqkfleekqaalwlegd

DSPn Dual specificity protein phosphatase, N-terminal half 12-151 8.9e-57 181.7 Pfam-A 2-141 (141) alignment
Range on Protein: 12-151
Range on HMM: 2-141/141.0
EIIQDRLYFATLRNKPRSTTNTHYFCIDDEFQYENFYADFGPLNLALLYRYCCKLNKKLKSTSLSRKKIVHYTSFDSKKRTNAACLIGCYAVRYFHQTPN
|.|.|||||..|..||..| |||||.||.|..||.||||||||||| .||.|.|||||||...|..||||.|||.|.|||.|||.|||.||| . . .|.
eliedrLyfvslkkkpkktenthyfsiDeelvYepfyadFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytsldekkranaalLigaYavivlklspe

SSEISIYFVTADNLSIKDASFGACTYNLTLLDCLKGIDKA
.    .  |..  |. .|||.|..||.||.||||||..||
ealkplesvepsllpFrDAsygestyeltildclkglekA

0049772 (Phosphotyrosine protein) phosphatases II 118-325 7.6e-40 132.9 In-house 60-266 (314) alignment
Range on Protein: 118-325
Range on HMM: 60-266/314.0
YFVTADNLSIKDASFGACTYNLTLLDCLKGIDKaVTHGFLDFENFDVEEYEHYERVENGDFNWIVPNK---------------------YLAFSGPHpks
 .| ...|.... ..  . |  . |...    .   ... ||....| .|.....|..||.|.... .                     .| ..|..   
nrvilpglpvsgsdyinasyvdgflkfIatqgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...

kiengyPYHaPEAYFPYFRkhnitsivrlnKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAISES--SEGSLAVHCKAGLGRTGT-LIGCYIMK
      ..  ..|......           . .||. .|...|. .... . |||.|.......||.. |.   .| ..|||||| ||||| .. .|.||
......nep.taadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmk

HFRFTAAEVIAWMRICRPgsvIGPQQHYMEEK
.......|.....| .||   |.|.....|  
llgvsleealedvrlkRp...inpnpgfieql

0050432 (Phosphotyrosine protein) phosphatases II 121-321 8.7e-40 132.3 In-house 8-289 (308) alignment
Range on Protein: 121-321
Range on HMM: 8-289/308.0
TADNLSIKDASFGACTYNLTLLDCLKGIDKAVTHGFLD------FENFDVEEYEHYERVENGDFNW-------------------------------IVP
. . |  .|.|. .....|..||.|| ..||   |.|.      .......||......||.|.|.                               ..|
llelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklp

NKYLAFSGPHpkskiengypYHAPEAYFPYFRKHNITSIVRLNKKIYD-----ARRFTDA---GFDHYDLFFI---------------------------
.|..|. ||.          ..  | .. .. ..|.. ||.|.| ...     |. . .    |. .|. |..                           
rkfIatqgPl..........pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesr

-----------DGSTPSD-SILQKFLAISESS--EGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQHY
           |...|.. .|| .|| . ..|  .|  .|||.||.|||||.| ....     |. .... |.....| .|||.|..|.|..
tvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqyl

0039614 (Phosphotyrosine protein) phosphatases II 127-320 1.4e-37 125.1 In-house 4-278 (297) alignment
Range on Protein: 127-320
Range on HMM: 4-278/297.0
IKDASFGACTYNLTLLDCLKGIDKAVTHGFLDFENFDV----EEYEHYERVENGDFNWIV------------------------------------PNKY
. ||... ... |. ||.|....||   ..|. | ...    ..|......||.|.|...                                    ..|.
lrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

LAFSGPHPKskiengypyhAPEAYFPYFRKHNITSIVRLNKKIYDARRF----------------TDAGFDHYDLFF-----------------------
.|..||.|.           .| .. .......|.||.|.| ... | .                |  ...|.| ..                       
IatqgPlpe..........tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgw

IDGSTP-SDSILQKFLAISES------SEGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
 |...| | ..|..|| . ..      ..|  .|||.||.|||||.|..|.|     |. .... |.....| .|||.|  |.| 
pdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy

0045450 (Phosphotyrosine protein) phosphatases II 127-320 1.8e-36 121.9 In-house 8-293 (307) alignment
Range on Protein: 127-320
Range on HMM: 8-293/307.0
IKDASFGACTYNLTLLDCLKGIDKAVThGFLDFENFDVEEYEHYERVENGDFNWI-------------------------------------------VP
. || .. . ..|.|||.| |. |.    .|... |.. ||......||.|.|..                                           ..
fidalkllllvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlk

NKYLAFSGPHPKskiengypyhAPEAYFPYFRKHNITSIVRLNKKIYDARR------------------------------------------FTDAGFD
.|..|. ||.|.           .| .. .......| ||.|.. ....|.                                          .|. .. 
rkfIatqgPlpe..........tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrt

HYDLFF---IDGSTPSD-SILQKFLAISES------SEGSLAVHCKAGLGRTGTLIGCYIMKHFR--------FTAAEVIAWMRICRPGSVIGPQQH
.. ...    |...|.. ..| .|. . ..      ..|  .|||.||.|||||.|..|.|.. .        ... |.....| .|||.|  |.| 
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

0043336 (Phosphotyrosine protein) phosphatases II 133-320 6.7e-37 122.8 In-house 3-266 (278) alignment
Range on Protein: 133-320
Range on HMM: 3-266/278.0
GACTYNLTLLDCLKGIDKAVTHGFLDFENFDVEEYEHYERVENGDFNWIV----------------------------------PNKYLAFSGPHPKski
. ...  .||..|..  ...  .| .. .|....|......||.|.|...                                  |.|..|..||.|.   
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe...

engypyhAPEAYFPYFRKHNITSIVRLNKKI--------------------------------------------YDARRFTDAGFDHYDLFfiDGSTP-
        .| .. .......|.||.|..                                              .|   .|  .. ...    |...| 
.......tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpe

SDSILQKFLAISES----SEGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
| |.|..|| .  .    |.| ..|||.||.|||||.|..|..     |. .... |.....| .|||.|  |.| 
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy

0040438 (Phosphotyrosine protein) phosphatases II 135-321 8.7e-39 129.0 In-house 3-266 (317) alignment
Range on Protein: 135-321
Range on HMM: 3-266/317.0
CTYNLTLLDCLKGIDKAVTHGFLDFENFDVEEYEHYERVENGDFNWIV----------------------------------PNKYLAFSGPHPKskien
. ..|.|||.||.  .|.  .| |. ......|...|..||.|.|...                                  ..|..|..||.|.     
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpn.....

gypyhAPEAYFPYFRKHNITSIVRLNKKIYD------------------------ARRFTDAGFDHYDLFF-------------------IDGSTP-SDS
       | .. .. ....|.||.|..  ..                           ...||. .. | .                    |...| | .
.....tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspd

ILQKFLAISESS----EGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQHY
.|..|| . ...    .| ..|||.||.|||||.|..|.|     |. .... |.....| .|||.|  |.| .
llldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyr

0045098 (Phosphotyrosine protein) phosphatases II 153-328 1.7e-36 121.5 In-house 11-270 (278) alignment
Range on Protein: 153-328
Range on HMM: 11-270/278.0
THGFLDFENFDVEEYEHYERVENGDFNWIV----------------------PNKYLAFSGPHPkskiengypyHAPEAYFPYFRKHNITSIVRLNKKIY
. ..  .  ... |.... ...|.|.|...                      |.|..|. ||.|          .  .... ......||.||.|.. ..
lefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlp..........stvadfwrmlwelgitvivmltelve

DA----------------------------------------------RRFTDAGFDHYDL-FFIDGSTPSDSILQKFLAISE-----------------
..                                                .. .|. |... .. |...||..||. || . |                 
lgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

---SSEGSLAVHCKAGLGRTGTLIGCYIMKHF---RFTAAEVIAWMRICRPG-SV-IGPQQHYMEEKQAA
   .|.|  .|||.||.||||||...|.|..    .... |.....| .||| .| .  |.....| .. 
llldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle

0044763 (Phosphotyrosine protein) phosphatases II 158-333 1e-35 118.4 In-house 3-174 (178) alignment
Range on Protein: 158-333
Range on HMM: 3-174/178.0
DFENFDVEEYEHYERVENGDFNWIVPNKYLAFSGPhpkskiengypyhapEAYFPYFRKHNITSIVRLNKKIY------DARRFTDAGFDHYDLFFIDGS
|.  ......|..||... ....|.|. ||.  .|               ...........||.||.|.. ..      |.  ...||. .. . . |..
drtrvllsnleglersdyinaseilpglylgslpp...............addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhg

TPS-DSILQKFLAISE----SSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPGSVIGPQQHYMEEKQAAMWVQG
.|. ......|... |    ...|  .|||.||.||.|||. .|.||...... |.|...| .||..    |.....| .  .. ..
vpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkes

0047943 (Phosphotyrosine protein) phosphatases II 160-321 1e-27 92.8 In-house 23-262 (273) alignment
Range on Protein: 160-321
Range on HMM: 23-262/273.0
ENFDVEEYEHYERVENGDFNWI------------------------------VPNKYLAFSGPHPKSkiengypyhaPEAYFPYFRKHNITSIVRLNKKI
..... .|......||.|.|..                              ...|..|. || |..           | .. .. ..|.. ||.|.. .
slkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpnt..........vedfwrmvweqnvrviVmLtelv

YDARR---------------------------FTDAGFDHYDLFFI-------------------DGSTP-SDSILQKFLAISES------SEGSLAVHC
.. |.                           .|.... .. |                      | ..| | ..| .|. . ..      |.|  .|||
elgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC

KAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQHY
.||.|||||.| ....     |. .... |.....| .|||.|. |.| .
saGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr

0041856 (Phosphotyrosine protein) phosphatases II 161-335 1.1e-42 141.0 In-house 1-175 (182) alignment
Range on Protein: 161-335
Range on HMM: 1-175/182.0
NFDVEEYEHYERVENGDFNWIVPNKYLAFSGPHPKSKIENGYPYHAPEAYFPYFRKHNITSIVRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQK
|.| ..|... ..... ... . ......| |. .  . .|.... ............||.||.|.   |.. .....|. ...|.. |...|. ..| .
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelld

FLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPGSVIGPQQHYMEEKQAAMWVQGDI
|. . ....|  .|||.||.||||||...|.||. .... |.....| .|||.|| |.|....  .. .......
fieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk

PTEN_1 163-327 5.1e-28 93.2 In-house 10-189 (196) alignment
Range on Protein: 163-327
Range on HMM: 10-189/196.0
DVEEYEHYERVENGDFNWIVPNKYLAFSGPHPKSKIENGYPYHAP--EAYFPYFRKHNITSIVRLNK------KIYDARRFTDAGFDHYDLFFIDGSTPS
. . ... | .... ... .  .  |.| | ..  .|. |  ...  .|..  . ...||..|.|.       . || . | . |. .... . |  .||
kknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgaps

DSILQKFLAISESS------EGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICR-PGSVIGPQQHYMEEKQA
 | |.....  ...      ..  .|||||||||.||.. .| |.. ..|| | ....|..| ||..  |.|   .| .|
lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfa

0036941 (Phosphotyrosine protein) phosphatases II 164-321 1e-19 66.4 In-house 28-267 (297) alignment
Range on Protein: 164-321
Range on HMM: 28-267/297.0
VEEYEHYERVENGDFNWIV------------------------------PNKYLAFSGPHPkskiengypyHAPEAYFPYFRKHNITSIVRLNKKIYDAR
  ........|| . |                                 ..|..|  || |          .  | ..    ..|.|.|| |.. . . |
lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlp..........ntvedFWrmvweqnvtvIvmltelvelgr

R-----FT-----------------------DAGFDHYDL-------------------FFIDGSTPS-DSILQKFLAISES------SEGSLAVHCKAG
      .                        ....  . |                      | ..|.  ..| .|.   ..      |.|   |||.||
ekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

LGRTGTLIGCYIM--------KHFRFTAAEVIAWMRICRPGSVIGPQQHY
.||.||.|....|        |. ...  |.. ..| .|||.|  ..| .
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyr

0038934 (Phosphotyrosine protein) phosphatases II 165-325 1.7e-40 134.1 In-house 4-169 (194) alignment
Range on Protein: 165-325
Range on HMM: 4-169/194.0
EEYEHYERVENgdfnwIVPNKYLAFSGPHPKSKIENGYPYH--APEAYFPYFRK--HNITSIVRLN--KKIYDARRFTDAGFDHYDLFFID-GSTPSDSI
.....||||..     |.... .||..|...|  .. ....  .|| .. |..   .... ...|.  .. ||...|..||.....|.|.| |..||..|
drwlkyervgd.....iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

LQKFLAI-----SESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPGSVigPQQHYMEEK
|..|| .     .|...|  ||||||||||||||...|........| | ||..|..|||..  |.|.|.|. 
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyleal

0043147 (Phosphotyrosine protein) phosphatases II 165-323 4.5e-35 116.3 In-house 2-153 (172) alignment
Range on Protein: 165-323
Range on HMM: 2-153/172.0
EEYEHYERVENGDFNWiVPNKYLAFSGPhpkskiengyPYHAPEAYFPYFRKHNITSIVRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAI
.|...|..... |... .|....|. ||            .  . .. ......|| ||.|..  ||.  ... |. .. | . |...|. ..|..|| .
degsdyinasyldlyy.ipdrfiatqgp..........lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflef

SES-----SEGSLAVHCKAGLGRTGTLIGCYIMKhFRFTAAEVIAWMRICRPGSVIGPQQHYME
 ..     ..|  .|||.||.||||||. .|.|.  .... |..|..| .|||.|  |.|..  
idellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrfl

0040439 (Phosphotyrosine protein) phosphatases II 166-320 2.7e-30 101.2 In-house 2-235 (249) alignment
Range on Protein: 166-320
Range on HMM: 2-235/249.0
EYEHYERVENGDFNWIV----------------------------------PNKYLAFSGPHPKskiengypyhAPEAYFPYFRKHNITSIVRLNKKI--
||......||.| |...                                  .....|..|| |.          . |... ......||.||.|..    
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..........tvedfwrmlwelgitvivmLtslvel

-------------------------------------------YDARRFTDAGFDHYDLFfiDGSTP-SDSILQKFLAISES------SEGSLAVHCKAG
                                           ||   .|  .. ..|.   | ..| | ..| .|. . ..      ..| ..|||.||
grekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaG

LGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
.|||||.|..|.|     |. .... |.....| .|||.|  |.| 
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqy

0042113 (Phosphotyrosine protein) phosphatases II 167-321 6.3e-31 103.1 In-house 1-233 (245) alignment
Range on Protein: 167-321
Range on HMM: 1-233/245.0
YEHYERVENGDFNWI----------------------------------VPNKYLAFSGPHPKskiengypyhAPEAYFPYFRKHNITSIVRLNKKIYD-
|......||.|.|..                                  ...|..|..||.|.           .|... ......||.||.|..  .. 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe..........tvedfwrmlwelgittivmLteeeelg

------------------------------------------ARRFTDAGFDHYDLFFIDGSTPS-DSILQKFLAISES-----SEGSLAVHCKAGLGRT
                                             ..  .. .. | . |...|. ...|..|| . ..     |.| ..|||.||.|||
rvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt

GTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQHY
||.|..|.|     |. .... |.....| .|||.|  |.| .
GtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyr

0036282 (Phosphotyrosine protein) phosphatases II 169-320 2.2e-30 101.0 In-house 3-159 (174) alignment
Range on Protein: 169-320
Range on HMM: 3-159/174.0
HYERVENGDFNWIVPnKYLAFSGPHPkskiengypyhapeaYFPYFRKHNITSIVRLNKKIYDA------------RRFTDAGFDHYDLFFIDGSTPSDS
.|... . |...| | ...|..||..               .........||..|.|.. ...               ... |. ...| . |...|..|
dyinaspldlsyitp.rliagqgpla...............fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdls

ILQKFLAISESS-----EGSLAVHCKAGLGRTGTLIGCYIMKHFRF-TAAEVIAWMRICR---PGSVIGPQQH
||..|. . |.      .| ..|||.||.||||||...|.|..  . .. ......| .|   ||.|. |.| 
illefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQy

0046846 (Phosphotyrosine protein) phosphatases II 172-321 3e-29 97.4 In-house 6-163 (176) alignment
Range on Protein: 172-321
Range on HMM: 6-163/176.0
RVENGDFNWIVPNKYLAFsgphpKSKIENGYPYHAPEAYFPYFRKHNITSIVRLNKK--------IYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLA
.....|...|..| .|       .  .  |  ..  .... ......|| .|.|..          ..  .....|. .. | . |...|....|...|.
lgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllelle

ISESSE---GSLAVHCKAGLGRTGTLIGCYIMKH-FRFTAAEVIAWMRICRP-GSVIGPQQHY
. ..     |  .|||.||.||||||. .|.... . ... |..|..| .|| |.|  |.| .
firealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyr

0037934 (Phosphotyrosine protein) phosphatases II 173-320 1.5e-30 102.0 In-house 34-231 (243) alignment
Range on Protein: 173-320
Range on HMM: 34-231/243.0
VENGDFNWIVPNkYLAFSGPHPKskiengYPYHAPEAYFPYFRKHNITSIVRLNKKI------------------------------------------Y
  |... ...|. . |..||.|.         ....... .. ...||.|| |.. .                                          .
yinanliyvtpr.liatqgPlpe......tveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenl

DARRFTDAGFDHYDLFFIDGSTPS-DSILQKFLAI------------SESSEGSLAVHCKAGLGRTGTLIGCYIMKHF-RFTAAEVIAWMRICRPG-SVI
|.  .|  .. .. | . |...|.  ..|..|| .             ..|.| ..|||.||.||||||| .|.|..  .... |.....| .||| .| 
dlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavq

GPQQH
 |.| 
tpsqy

0048567 (Phosphotyrosine protein) phosphatases II 173-225 2e-07 25.5 In-house 2-59 (157) alignment
Range on Protein: 173-225
Range on HMM: 2-59/157.0
VENGDFNWIVPNKYLAFSGPHPKSKIENGYPYHAPE--AYFPYFRKH---NITSIVRL
.||||...|.|........|.......| .... ..   |...|...   |.. ..|.
kengdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrF

0051082 (Phosphotyrosine protein) phosphatases II 177-323 3.6e-31 103.2 In-house 7-145 (151) alignment
Range on Protein: 177-323
Range on HMM: 7-145/151.0
DFNWIVPNkYLAFSGPHPkskiengypyhapeAYFPYFRKHNITSIVRLNKKI---YDARRFTDAGFDHYDLFFIDGSTPSD----SILQKFLAISESS-
.|... .. .....||..              ..........|..|| |...    |........|...... ..| ..|.      ....|| . ..  
nfsyvtgg.lyrsggpla..............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkk

EGSLAVHCKAGLGRTGTLIGCYIMKhFRFTAAEVIAWMRICRPGSVIGPQQHYME
.| ..|||.||.||||||...|.|.  .....|.....|..|||.|. .||....
ngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfq

0051429 (Phosphotyrosine protein) phosphatases II 178-322 5.7e-19 64.3 In-house 16-216 (272) alignment
Range on Protein: 178-322
Range on HMM: 16-216/272.0
FNWIVPNKYLAFSGPHPKSkiengypyhapEAYFPYFRKHNITSIVRLNKKIYDAR---RFTDAGFDHYDLFFIDGSTPSD-------------------
.....|..... .||.| .           .| |.......|..|| | .  . .|    .  .|.... | ..| |.|.                    
grvvkpgrlyrsggplplt...........aadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyi

---------------------------------SILQKFLAISESsEGSLAVHCKAGLGRTGTLIGCYIMKhFRFT--------------AAEVIAWMRI
                                 . | ..|..  . .| . |||.|| .||||.. ....   ...              ..|.....| 
lrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelra

CRPGSVIGPQQHYM
.|||.|  ..| ..
qrpgavqteeqylf

0046845 (Phosphotyrosine protein) phosphatases II 180-321 8.8e-23 76.5 In-house 73-264 (284) alignment
Range on Protein: 180-321
Range on HMM: 73-264/284.0
WIVPNKYLAFSGPHPK-------------------------SKIENGYPYHAPEAYFPYFRKHNITSIVRLNKKIYDARRF-------TDAGFDHYDLFF
.....|..|..|| |.                          . |  ..|  .|  . .. .  .| . . .|. |  |..       |.  . .. . .
tyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhy

I---DGSTP-SDSILQKFLAISESS------EGSLAVHCKAGLGRTGTLIGCYIMKHF--------RFTAAEVIAWMRICRPGSVIGPQQHY
.   | ..| | ..|..|| . ...      .|  .|||.||.|||||.| ......         .... |.....| .|||.|  ..| .
tswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyr

0051299 (Phosphotyrosine protein) phosphatases II 181-320 3.9e-20 67.9 In-house 89-275 (288) alignment
Range on Protein: 181-320
Range on HMM: 89-275/288.0
IVPNKYLAFSGPHPkskiengypyHAPEAYFPYFRKHNITSIVRLNKKI-------------------------------------------------YD
  ..|..|. || |          .  | .. .  ..|.. ||.|.| .                                                 .|
nlkrkfIatqgPlp..........ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgd

ARRFTDAGFDHYDLFfiDGSTPS-DSILQKFLAISESS----EGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
   .|   | ...    | ..|.  . | .|| .  ..    .|  .|||.||.|||||.| ....     |. .... |.....| .|||.|. |.| 
gesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqy

0049260 (Phosphotyrosine protein) phosphatases II 201-322 7.1e-32 105.6 In-house 16-141 (152) alignment
Range on Protein: 201-322
Range on HMM: 16-141/152.0
GYPYHAPEAYFPYFRKHNITSIVRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAI-----SESSEGSLAVHCKAGLGRTGTLIGCYIMKhF
|.  .  . .. ......|| ||.|..  .... ... .. .. |.. |...|..|.| .|| .      ....|  .|||.||.||||||. .|.|. .
gpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.l

RFTAAEVIAWMRICRPGSVIGPQQHYM
.... |..|..| .|||.|. |.| . 
gvsleeavalvrekRpgavpnpgqlrf

subfamily_RNGTT_pd Subfamily RNGTT 208-324 1.1e-09 32.3 In-house 42-166 (189) alignment
Range on Protein: 208-324
Range on HMM: 42-166/189.0
EAYFPYFR--KHNITSIVRLN--KKIYDARRFTDAGFDHYDLFFI-DGSTPSDSILQKFLAISES-----SEGSLAVHCKAGLGRTGTLIGCYIMKHFRF
.  . |..  |...  .. |   .. ||.. ... |  .  |     | .|.    ..|  . |.     .|  ..|||. |  ||| || .|....  .
smllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedw

TAAEVIAWMRICRPGSVIgpQQHYMEE
 . . .|  . .||  .   ...|..|
sveaavalFakaRppGiy..kedylke

subfamily_PRL_pd Subfamily PRL 209-327 1.1e-16 55.2 In-house 25-147 (151) alignment
Range on Protein: 209-327
Range on HMM: 25-147/151.0
AYFPYFRKHNITSIVRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAI-----SESSEGSLAVHCKAGLGRTGTLIGCYIMKHfRFTAAEVI
 .   ..|......||  .  ||.. . ..| .  || | ||..|........|..     .|... ..|||| |||||.  |.   .. .  ..  . .
kfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyedav

AWMRICRPGSVIGPQQHYMEEKQA
 ..|  | |..   | ...|. .|
efirekrrgainskqlkflekyka

0048179 (Phosphotyrosine protein) phosphatases II 210-320 6.4e-26 86.2 In-house 21-134 (144) alignment
Range on Protein: 210-320
Range on HMM: 21-134/144.0
YFPYFRKHNITSIVRLNKKiYDARRFTDAGFDHYDLFFIDGSTPSD-SILQKFLAISESS---EGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAW
 .....|..|| ...|. . |.   ... |. .. | . | ..|.. ..|..||.. |.    .|  .|||.||.||||||. .|.||...... |..|.
dlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealal

MRICRPGSVIGPQQH
.| .|||.|. |.| 
vrsrrpgavpnpgql

0048076 (Phosphotyrosine protein) phosphatases II 211-320 4.3e-25 83.5 In-house 22-132 (145) alignment
Range on Protein: 211-320
Range on HMM: 22-132/145.0
FPYFRKHNITSIVRLnkkIYDARRFTDAGFDHYDLFFIDGSTPSD-SILQKFLAISESS---EGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWM
........|| ...|    .. . ... |. .. | . | ..|.. ..|..||.. |.    .|  .|||.||.||||||...|.|....... |.....
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelv

RICRPGSVIGPQQH
| .|||.|. |.| 
rsqrpgavpnpgql

0048567 (Phosphotyrosine protein) phosphatases II 214-330 1.4e-34 113.6 In-house 12-138 (157) alignment
Range on Protein: 214-330
Range on HMM: 12-138/157.0
FRKHNITSIVRLNKKIYDARRF-TDAGFDHYDLFFIDGstPSD--------SILQKFLAISESSEGSLAVHCKAGL---GRTGTLIGCYIMKHFRFTAAE
. ... .. .||.|..|.|  | .|.|. ..|.|| .|  | .         .| ||| | |  .. .||||||||   |||.||||||...|..||..|
pdrlyfallprlpkslynalyFsiddglvyedfffdfG..PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpee

VIAWMRICRPGSVIGPQQHYMEEKQAAMW
.||..||.|||||......|.. ..  ..
aiaplrivrpgsvpfrdasyllslynltl

PTPc_motif_SM00404 216-324 1.5e-12 42.6 In-house 25-133 (140) alignment
Range on Protein: 216-324
Range on HMM: 25-133/140.0
KHNITSIVRLNKKIY---DARRFTDAGFDhYDLFFIDGSTPSDSILQKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpg
|..|| .. . ...       .|.    .  |    |  ..  . . .|.  .|...|.  |||.||. |..||| .|.|.   ...||..  ..  |  
klgithvinvteevsltkensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR..

SVIGPQQHYMEE
. | |. .....
piispnlnfvrq

subfamily_DSP1_pd Subfamily DSP1 216-323 8.2e-08 26.5 In-house 41-147 (163) alignment
Range on Protein: 216-323
Range on HMM: 41-147/163.0
KHNITSIVRLNKKIYDArrFTDaGFDHYDLFFIDgSTPSDsIL------QKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRIC
...|| |. . |.. ..  | |  | .. |   | |.  | |        .|.   ....| . .||.||. |  ||.  |.||. |..  |   ...  
slgitailnvskeldnv..fed.lfeYkklkleD.spkad.islvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqr

RpgSVIGPQQHYME
|  |.| |   .. 
R..siisPnagFvl

subfamily_DSP15_pd Subfamily DSP15 216-311 6.6e-07 23.5 In-house 25-120 (151) alignment
Range on Protein: 216-311
Range on HMM: 25-120/151.0
KHNITSIVRLNKkiyDARRFTDAgfDHYDLFFIDGsTPSDSIL------QKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRIC
..||| |. ..    .|... .    .| .. ..  |||  .        .|.  . . |..  ||| ||. |  ||.  |.|    .   ...  .. .
eknithilsvhd...nakkllkd..ieYkciaasD.tpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaa

RP
| 
Rs

subfamily_PTPMT1_pd Subfamily PTPMT1 217-313 2.5e-11 38.3 In-house 45-151 (171) alignment
Range on Protein: 217-313
Range on HMM: 45-151/171.0
HNITSIVRLNKKI------YDARRFTDAGFDHYDLFFIDGS-TPSDSILQK---FLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWM
.|. ..| ||.           ....  | ... |  .|   .|.   |.|   |.    |.  .. |||||| ||..||..||.||. ...  | .  .
envkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkal

RICRPGS
. .|.  
kkkRkii

subfamily_PTPRK_pd Subfamily PTPRK 218-293 9.8e-06 19.6 In-house 161-234 (314) alignment
Range on Protein: 218-293
Range on HMM: 161-234/314.0
NITSIVRLNKKIYDARRFTDAGFDHYDLFFIDgsTPSDSILQKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMK
... . |  ..|   |.|   |. ..|       |   .....  . .| ..| . ||| || ||||| | . |. 
rveklargqeeirevrqfqflgWpdhdvPvsa..tgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl

subfamily_DSP3_pd Subfamily DSP3 223-322 3e-06 21.0 In-house 51-147 (162) alignment
Range on Protein: 223-322
Range on HMM: 51-147/162.0
VRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILqKFLAIS-ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPgsvIGPQQHY
|  ... |.   ..  |..  | . .| |.  ..   ||.. . ...|| . |||..|. |  ||.  |.| . ..|. | |  .|  |    |.| . .
vdtgaefykdleikylGlevdDvpefdlskyFetaa.kfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe...ilPneGF

M
.
l

subfamily_DSP11_pd Subfamily DSP11 227-324 1.1e-08 29.1 In-house 67-169 (178) alignment
Range on Protein: 227-324
Range on HMM: 67-169/178.0
KKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAI-------SESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpGSVIGpQQ
.. |. . .|| |  .. |.    ..|.. ...|| .        .. ..  ..|||  |. ||| ||  |....  . . . |  .  .| |  .  ..
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear.Ghsle.re

HYMEE
.|...
nylkd

subfamily_PTEN_pd Subfamily PTEN 228-306 1.9e-09 32.8 In-house 71-152 (184) alignment
Range on Protein: 228-306
Range on HMM: 71-152/184.0
KIYDARRFtDAGFDHYDlfFIDGSTPSDSILQKFLA-----ISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAA-EVIAWM
. ||...| |    .|.  | |  .|. ..|....      ..|...   .|||||| ||||.|| .|..|.  .. | |.... 
rkydskkf.dgrvavyp..fdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelf

subfamily_PTPDC1_pd Subfamily PTPDC1 230-319 8.3e-15 49.7 In-house 73-164 (182) alignment
Range on Protein: 230-319
Range on HMM: 73-164/182.0
YDARRFTDAGFDHYDLFFIDGSTPS-DSILQKFLAIS-ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPGSVIGPQQ
||   ....|  .| . . | ...| ..||.    ..   .|| .|||| ||||||| || ||.. . |.||.. |  .|  || |.   .|
YdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreq

subfamily_DSP23_pd Subfamily DSP23 253-319 4.9e-14 47.2 In-house 65-134 (148) alignment
Range on Protein: 253-319
Range on HMM: 65-134/148.0
PSDSILQKFLAISESS---EGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPGSVIGPQQ
|.   ...|. . | .   . ...|||  | |||||.. ||..|. ...||| || .|  |||||   .|
paleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveq

PTPc_DSPc_SM00012 255-310 2e-08 29.7 In-house 20-86 (105) alignment
Range on Protein: 255-310
Range on HMM: 20-86/105.0
DSILQKFLAISESSE-----GSLAVHCKAGLGRTGTLIGCYIMKHFRFTAA------EVIAWMRICR
||||. . |. .. .     ... |||.|| |||||..  .|. .   .        ...  .|  |
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqR

DSPc_SM00195 255-320 2.5e-07 25.6 In-house 178-251 (263) alignment
Range on Protein: 255-320
Range on HMM: 178-251/263.0
DSILQKFLAISESS---EGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
.|.|. . |. .|.   .| . |||.||.|||||..   |.     .....   |..  .|  |||.|   .|.
ksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqY

PTPc_SM00194 255-320 2.5e-07 25.6 In-house 178-251 (263) alignment
Range on Protein: 255-320
Range on HMM: 178-251/263.0
DSILQKFLAISESS---EGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
.|.|. . |. .|.   .| . |||.||.|||||..   |.     .....   |..  .|  |||.|   .|.
ksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqY

DSPc Dual specificity phosphatase, catalytic domain 258-323 1.1e-12 42.9 Pfam-A 62-125 (133) alignment
Range on Protein: 258-323
Range on HMM: 62-125/133.0
LQKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpgSVIGPQQHYME
. .|..  |..... .|||.||. |..||| .|.|| ..... | .. ..  |  | | |. ... 
avefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..skispnagflr

DSPc Dual specificity phosphatase, catalytic domain 258-323 1.1e-12 42.9 In-house 62-125 (133) alignment
Range on Protein: 258-323
Range on HMM: 62-125/133.0
LQKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpgSVIGPQQHYME
. .|..  |..... .|||.||. |..||| .|.|| ..... | .. ..  |  | | |. ... 
avefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..skispnagflr

subfamily_DSP19_pd Subfamily DSP19 259-321 1e-07 26.4 In-house 79-139 (152) alignment
Range on Protein: 259-321
Range on HMM: 79-139/152.0
QKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPgsVIGPQQHY
..|.  . |..| . |||.||  |. ...  |.||. . .  | .  .|  ||   | | . .
ldFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearp..cikPneGF

subfamily_PTPN6_pd Subfamily PTPN6 259-288 7.8e-06 20.1 In-house 217-246 (306) alignment
Range on Protein: 259-288
Range on HMM: 217-246/306.0
QKFLAISESSEGSLAVHCKAGLGRTGTLIG
.|   ..|...|.. ||| ||.|||||.| 
rkqeeleeaeagpivvhCsaGiGRtGtfiv

Y_phosphatase Protein-tyrosine phosphatase 260-318 1.5e-06 23.2 Pfam-A 157-224 (235) alignment
Range on Protein: 260-318
Range on HMM: 157-224/235.0
KFLAIS----ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRF-----TAAEVIAWMRICRPGSVIGPQ
...       |...|.. |||.|| |||||..   |. .           ...  .| .|||.|   .
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsle

Y_phosphatase Protein-tyrosine phosphatase 260-318 1.5e-06 23.2 In-house 157-224 (235) alignment
Range on Protein: 260-318
Range on HMM: 157-224/235.0
KFLAIS----ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRF-----TAAEVIAWMRICRPGSVIGPQ
...       |...|.. |||.|| |||||..   |. .           ...  .| .|||.|   .
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsle

subfamily_Slingshot_pd Subfamily Slingshot 260-326 1.8e-06 21.4 In-house 87-151 (169) alignment
Range on Protein: 260-326
Range on HMM: 87-151/169.0
KFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpgSVIGPQQHYMEEKQ
||.  . ... .. |||| |. |. . .  | ||.....  | .....  |  ||| | . ...  .
kfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerr..svikPnkgflkqle

subfamily_DSP8_pd Subfamily DSP8 260-319 3.8e-06 20.5 In-house 84-141 (159) alignment
Range on Protein: 260-319
Range on HMM: 84-141/159.0
KFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpgSVIGPQQ
.|.    |..|.  ||. ||  |  |.. .||||.....  |   ...  |   .| |. 
efidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr..ptispnl

subfamily_DSP12_pd Subfamily DSP12 261-311 2.8e-06 21.8 In-house 74-124 (155) alignment
Range on Protein: 261-311
Range on HMM: 74-124/155.0
FLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRP
|.  . . ||.. |||.||. |  |..  |.||. ..   . .  ..  .|
FieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp

subfamily_PTPN13_pd Subfamily PTPN13 264-327 2.5e-06 22.0 In-house 197-264 (273) alignment
Range on Protein: 264-327
Range on HMM: 197-264/273.0
ISESSEGSLAVHCKAGLGRTGTLIGCYI-----MKHFRFTAAEVIAWMRICRPgSVIGPQQHYMEEKQA
  ....| ..||| ||.||.||||  ..      .   |   |..  .|  |  .|.  .. |.   .|
rlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrq.gvvqtkdqyifvyka

subfamily_DSP10_pd Subfamily DSP10 266-322 7.2e-08 26.5 In-house 89-143 (159) alignment
Range on Protein: 266-322
Range on HMM: 89-143/159.0
ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPgsVIGPQQHYM
 ... .. |||.||. |  |..  |.|||.. .  .   ... .||  .| |   .|
rkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp..iisPnLnfm

subfamily_DSP14_pd Subfamily DSP14 266-317 2.6e-06 21.5 In-house 80-129 (157) alignment
Range on Protein: 266-317
Range on HMM: 80-129/157.0
ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPgsVIGP
. ..|   |||.||  |  .|   |.||. . . .|   ... .||  .| |
kkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRp..iirP