Gene CDC14 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP005_AA protein Get Run
SpurP005_AA_7-156 phosphatase_domain Get Run
SpurP005_AA_175-333 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0048567 (Phosphotyrosine protein) phosphatases II 6-160 1.7e-53 175.0 In-house 3-157 (157) alignment 
Range on Protein: 6-160
Range on HMM: 3-157/157.0
ELMSASEIIQDRLYFATLRNKPRSTTNTHYFCIDDEFQYENFYADFGPLNLALLYRYCCKLNKKLKSTSLSRKKIVHYTSFDSKKRTNAACLIGCYAVRY
|.....|||.||||||.|...|.|. |..||.|||...||.|..||||||||.|||...||||.||...| .|.|....... |||...|.|||||.. .
engdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilh

FHQTPNSSEISIYFVTADNLSIKDASFGACTYNLTLLDCLKGIDKAVTHGFLDFE
.. ||.     . .|  . .   |||.. ..|||||||.|.|. ||. .||||.|
lgftpeeaiaplrivrpgsvpfrdasyllslynltlldvlyGllkAlelgfldle
subfamily_CDC14_pd Subfamily CDC14 9-334 3.8e-174 573.1 In-house 2-328 (328) alignment 
Range on Protein: 9-334
Range on HMM: 2-328/328.0
SASEIIQDRLYFATLRNKPRSTTNTHYFCIDDEFQYENFYADFGPLNLALLYRYCCKLNKKLKSTSLSRKKIVHYTSFDSKKRTNAACLIGCYAVRYFHQ
.|.|...|||||||||.||.||...|||..|||..|||||||||||||| |||||.||||||||.. ..||||.|||.|||||.|||.|||.||| |...
nalelledrlyfatlrkkPkstselhyfsvddelkyenfyadfGPlnlavlyrycvklnkkLkseekaskkivlytsadskkranaalligayaviylkk

TPNSSEISIYFVT-ADNLSIKDASFGACTYNLTLLDCLKGIDKAVTHGFLDFENFDVEEYEHYERVENGDFNWIVPNKYLAFSGPHPKSKIENGYPYHAP
|....  .. ... .......|||.|...|.|||||.|||..||...||||.|.||.||||.||||||||||||||.|.||..|||.|||.|.|||.|||
taeeayraleaaetppfvpfrdasygsasykltlldvlkgvekalqkgfldledfdleeYekyervenGDfnwivPdkflalagPhnkskledgyplhaP

EAYFPYFRKHNITSIVRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMR
|....||||.|.|..||||||.|||..||||||||.||||||||||||.|..|||.|.|..||..|||||||||||||||.||.|||.||||||.|||.|
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlr

ICRPGSVIGPQQHYMEEKQAAMWVQGD
||||||||||||...||||||.|..||
icrPGsvigpqqkfleekqaalwlegd
DSPn Dual specificity protein phosphatase, N-terminal half 12-151 8.9e-57 181.7 Pfam-A 2-141 (141) alignment 
Range on Protein: 12-151
Range on HMM: 2-141/141.0
EIIQDRLYFATLRNKPRSTTNTHYFCIDDEFQYENFYADFGPLNLALLYRYCCKLNKKLKSTSLSRKKIVHYTSFDSKKRTNAACLIGCYAVRYFHQTPN
|.|.|||||..|..||..| |||||.||.|..||.||||||||||| .||.|.|||||||...|..||||.|||.|.|||.|||.|||.||| . . .|.
eliedrLyfvslkkkpkktenthyfsiDeelvYepfyadFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytsldekkranaalLigaYavivlklspe

SSEISIYFVTADNLSIKDASFGACTYNLTLLDCLKGIDKA
.    .  |..  |. .|||.|..||.||.||||||..||
ealkplesvepsllpFrDAsygestyeltildclkglekA
0049772 (Phosphotyrosine protein) phosphatases II 118-325 7.6e-40 132.9 In-house 60-266 (314) alignment 
Range on Protein: 118-325
Range on HMM: 60-266/314.0
YFVTADNLSIKDASFGACTYNLTLLDCLKGIDKaVTHGFLDFENFDVEEYEHYERVENGDFNWIVPNK---------------------YLAFSGPHpks
 .| ...|.... ..  . |  . |...    .   ... ||....| .|.....|..||.|.... .                     .| ..|..   
nrvilpglpvsgsdyinasyvdgflkfIatqgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...

kiengyPYHaPEAYFPYFRkhnitsivrlnKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAISES--SEGSLAVHCKAGLGRTGT-LIGCYIMK
      ..  ..|......           . .||. .|...|. .... . |||.|.......||.. |.   .| ..|||||| ||||| .. .|.||
......nep.taadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmk

HFRFTAAEVIAWMRICRPgsvIGPQQHYMEEK
.......|.....| .||   |.|.....|  
llgvsleealedvrlkRp...inpnpgfieql
0050432 (Phosphotyrosine protein) phosphatases II 121-321 8.7e-40 132.3 In-house 8-289 (308) alignment 
Range on Protein: 121-321
Range on HMM: 8-289/308.0
TADNLSIKDASFGACTYNLTLLDCLKGIDKAVTHGFLD------FENFDVEEYEHYERVENGDFNW-------------------------------IVP
. . |  .|.|. .....|..||.|| ..||   |.|.      .......||......||.|.|.                               ..|
llelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklp

NKYLAFSGPHpkskiengypYHAPEAYFPYFRKHNITSIVRLNKKIYD-----ARRFTDA---GFDHYDLFFI---------------------------
.|..|. ||.          ..  | .. .. ..|.. ||.|.| ...     |. . .    |. .|. |..                           
rkfIatqgPl..........pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesr

-----------DGSTPSD-SILQKFLAISESS--EGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQHY
           |...|.. .|| .|| . ..|  .|  .|||.||.|||||.| ....     |. .... |.....| .|||.|..|.|..
tvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqyl
0039614 (Phosphotyrosine protein) phosphatases II 127-320 1.4e-37 125.1 In-house 4-278 (297) alignment 
Range on Protein: 127-320
Range on HMM: 4-278/297.0
IKDASFGACTYNLTLLDCLKGIDKAVTHGFLDFENFDV----EEYEHYERVENGDFNWIV------------------------------------PNKY
. ||... ... |. ||.|....||   ..|. | ...    ..|......||.|.|...                                    ..|.
lrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

LAFSGPHPKskiengypyhAPEAYFPYFRKHNITSIVRLNKKIYDARRF----------------TDAGFDHYDLFF-----------------------
.|..||.|.           .| .. .......|.||.|.| ... | .                |  ...|.| ..                       
IatqgPlpe..........tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgw

IDGSTP-SDSILQKFLAISES------SEGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
 |...| | ..|..|| . ..      ..|  .|||.||.|||||.|..|.|     |. .... |.....| .|||.|  |.| 
pdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy
0045450 (Phosphotyrosine protein) phosphatases II 127-320 1.8e-36 121.9 In-house 8-293 (307) alignment 
Range on Protein: 127-320
Range on HMM: 8-293/307.0
IKDASFGACTYNLTLLDCLKGIDKAVThGFLDFENFDVEEYEHYERVENGDFNWI-------------------------------------------VP
. || .. . ..|.|||.| |. |.    .|... |.. ||......||.|.|..                                           ..
fidalkllllvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlk

NKYLAFSGPHPKskiengypyhAPEAYFPYFRKHNITSIVRLNKKIYDARR------------------------------------------FTDAGFD
.|..|. ||.|.           .| .. .......| ||.|.. ....|.                                          .|. .. 
rkfIatqgPlpe..........tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrt

HYDLFF---IDGSTPSD-SILQKFLAISES------SEGSLAVHCKAGLGRTGTLIGCYIMKHFR--------FTAAEVIAWMRICRPGSVIGPQQH
.. ...    |...|.. ..| .|. . ..      ..|  .|||.||.|||||.|..|.|.. .        ... |.....| .|||.|  |.| 
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy
0043336 (Phosphotyrosine protein) phosphatases II 133-320 6.7e-37 122.8 In-house 3-266 (278) alignment 
Range on Protein: 133-320
Range on HMM: 3-266/278.0
GACTYNLTLLDCLKGIDKAVTHGFLDFENFDVEEYEHYERVENGDFNWIV----------------------------------PNKYLAFSGPHPKski
. ...  .||..|..  ...  .| .. .|....|......||.|.|...                                  |.|..|..||.|.   
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe...

engypyhAPEAYFPYFRKHNITSIVRLNKKI--------------------------------------------YDARRFTDAGFDHYDLFfiDGSTP-
        .| .. .......|.||.|..                                              .|   .|  .. ...    |...| 
.......tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpe

SDSILQKFLAISES----SEGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
| |.|..|| .  .    |.| ..|||.||.|||||.|..|..     |. .... |.....| .|||.|  |.| 
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy
0040438 (Phosphotyrosine protein) phosphatases II 135-321 8.7e-39 129.0 In-house 3-266 (317) alignment 
Range on Protein: 135-321
Range on HMM: 3-266/317.0
CTYNLTLLDCLKGIDKAVTHGFLDFENFDVEEYEHYERVENGDFNWIV----------------------------------PNKYLAFSGPHPKskien
. ..|.|||.||.  .|.  .| |. ......|...|..||.|.|...                                  ..|..|..||.|.     
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpn.....

gypyhAPEAYFPYFRKHNITSIVRLNKKIYD------------------------ARRFTDAGFDHYDLFF-------------------IDGSTP-SDS
       | .. .. ....|.||.|..  ..                           ...||. .. | .                    |...| | .
.....tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspd

ILQKFLAISESS----EGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQHY
.|..|| . ...    .| ..|||.||.|||||.|..|.|     |. .... |.....| .|||.|  |.| .
llldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyr
0045098 (Phosphotyrosine protein) phosphatases II 153-328 1.7e-36 121.5 In-house 11-270 (278) alignment 
Range on Protein: 153-328
Range on HMM: 11-270/278.0
THGFLDFENFDVEEYEHYERVENGDFNWIV----------------------PNKYLAFSGPHPkskiengypyHAPEAYFPYFRKHNITSIVRLNKKIY
. ..  .  ... |.... ...|.|.|...                      |.|..|. ||.|          .  .... ......||.||.|.. ..
lefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlp..........stvadfwrmlwelgitvivmltelve

DA----------------------------------------------RRFTDAGFDHYDL-FFIDGSTPSDSILQKFLAISE-----------------
..                                                .. .|. |... .. |...||..||. || . |                 
lgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

---SSEGSLAVHCKAGLGRTGTLIGCYIMKHF---RFTAAEVIAWMRICRPG-SV-IGPQQHYMEEKQAA
   .|.|  .|||.||.||||||...|.|..    .... |.....| .||| .| .  |.....| .. 
llldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
0044763 (Phosphotyrosine protein) phosphatases II 158-333 1e-35 118.4 In-house 3-174 (178) alignment 
Range on Protein: 158-333
Range on HMM: 3-174/178.0
DFENFDVEEYEHYERVENGDFNWIVPNKYLAFSGPhpkskiengypyhapEAYFPYFRKHNITSIVRLNKKIY------DARRFTDAGFDHYDLFFIDGS
|.  ......|..||... ....|.|. ||.  .|               ...........||.||.|.. ..      |.  ...||. .. . . |..
drtrvllsnleglersdyinaseilpglylgslpp...............addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhg

TPS-DSILQKFLAISE----SSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPGSVIGPQQHYMEEKQAAMWVQG
.|. ......|... |    ...|  .|||.||.||.|||. .|.||...... |.|...| .||..    |.....| .  .. ..
vpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkes
0047943 (Phosphotyrosine protein) phosphatases II 160-321 1e-27 92.8 In-house 23-262 (273) alignment 
Range on Protein: 160-321
Range on HMM: 23-262/273.0
ENFDVEEYEHYERVENGDFNWI------------------------------VPNKYLAFSGPHPKSkiengypyhaPEAYFPYFRKHNITSIVRLNKKI
..... .|......||.|.|..                              ...|..|. || |..           | .. .. ..|.. ||.|.. .
slkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpnt..........vedfwrmvweqnvrviVmLtelv

YDARR---------------------------FTDAGFDHYDLFFI-------------------DGSTP-SDSILQKFLAISES------SEGSLAVHC
.. |.                           .|.... .. |                      | ..| | ..| .|. . ..      |.|  .|||
elgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC

KAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQHY
.||.|||||.| ....     |. .... |.....| .|||.|. |.| .
saGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr
0041856 (Phosphotyrosine protein) phosphatases II 161-335 1.1e-42 141.0 In-house 1-175 (182) alignment 
Range on Protein: 161-335
Range on HMM: 1-175/182.0
NFDVEEYEHYERVENGDFNWIVPNKYLAFSGPHPKSKIENGYPYHAPEAYFPYFRKHNITSIVRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQK
|.| ..|... ..... ... . ......| |. .  . .|.... ............||.||.|.   |.. .....|. ...|.. |...|. ..| .
nldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelld

FLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPGSVIGPQQHYMEEKQAAMWVQGDI
|. . ....|  .|||.||.||||||...|.||. .... |.....| .|||.|| |.|....  .. .......
fieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
PTEN_1 163-327 5.1e-28 93.2 In-house 10-189 (196) alignment 
Range on Protein: 163-327
Range on HMM: 10-189/196.0
DVEEYEHYERVENGDFNWIVPNKYLAFSGPHPKSKIENGYPYHAP--EAYFPYFRKHNITSIVRLNK------KIYDARRFTDAGFDHYDLFFIDGSTPS
. . ... | .... ... .  .  |.| | ..  .|. |  ...  .|..  . ...||..|.|.       . || . | . |. .... . |  .||
kknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgaps

DSILQKFLAISESS------EGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICR-PGSVIGPQQHYMEEKQA
 | |.....  ...      ..  .|||||||||.||.. .| |.. ..|| | ....|..| ||..  |.|   .| .|
lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfa
0036941 (Phosphotyrosine protein) phosphatases II 164-321 1e-19 66.4 In-house 28-267 (297) alignment 
Range on Protein: 164-321
Range on HMM: 28-267/297.0
VEEYEHYERVENGDFNWIV------------------------------PNKYLAFSGPHPkskiengypyHAPEAYFPYFRKHNITSIVRLNKKIYDAR
  ........|| . |                                 ..|..|  || |          .  | ..    ..|.|.|| |.. . . |
lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlp..........ntvedFWrmvweqnvtvIvmltelvelgr

R-----FT-----------------------DAGFDHYDL-------------------FFIDGSTPS-DSILQKFLAISES------SEGSLAVHCKAG
      .                        ....  . |                      | ..|.  ..| .|.   ..      |.|   |||.||
ekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

LGRTGTLIGCYIM--------KHFRFTAAEVIAWMRICRPGSVIGPQQHY
.||.||.|....|        |. ...  |.. ..| .|||.|  ..| .
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyr
0038934 (Phosphotyrosine protein) phosphatases II 165-325 1.7e-40 134.1 In-house 4-169 (194) alignment 
Range on Protein: 165-325
Range on HMM: 4-169/194.0
EEYEHYERVENgdfnwIVPNKYLAFSGPHPKSKIENGYPYH--APEAYFPYFRK--HNITSIVRLN--KKIYDARRFTDAGFDHYDLFFID-GSTPSDSI
.....||||..     |.... .||..|...|  .. ....  .|| .. |..   .... ...|.  .. ||...|..||.....|.|.| |..||..|
drwlkyervgd.....iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

LQKFLAI-----SESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPGSVigPQQHYMEEK
|..|| .     .|...|  ||||||||||||||...|........| | ||..|..|||..  |.|.|.|. 
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyleal
0043147 (Phosphotyrosine protein) phosphatases II 165-323 4.5e-35 116.3 In-house 2-153 (172) alignment 
Range on Protein: 165-323
Range on HMM: 2-153/172.0
EEYEHYERVENGDFNWiVPNKYLAFSGPhpkskiengyPYHAPEAYFPYFRKHNITSIVRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAI
.|...|..... |... .|....|. ||            .  . .. ......|| ||.|..  ||.  ... |. .. | . |...|. ..|..|| .
degsdyinasyldlyy.ipdrfiatqgp..........lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflef

SES-----SEGSLAVHCKAGLGRTGTLIGCYIMKhFRFTAAEVIAWMRICRPGSVIGPQQHYME
 ..     ..|  .|||.||.||||||. .|.|.  .... |..|..| .|||.|  |.|..  
idellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrfl
0040439 (Phosphotyrosine protein) phosphatases II 166-320 2.7e-30 101.2 In-house 2-235 (249) alignment 
Range on Protein: 166-320
Range on HMM: 2-235/249.0
EYEHYERVENGDFNWIV----------------------------------PNKYLAFSGPHPKskiengypyhAPEAYFPYFRKHNITSIVRLNKKI--
||......||.| |...                                  .....|..|| |.          . |... ......||.||.|..    
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..........tvedfwrmlwelgitvivmLtslvel

-------------------------------------------YDARRFTDAGFDHYDLFfiDGSTP-SDSILQKFLAISES------SEGSLAVHCKAG
                                           ||   .|  .. ..|.   | ..| | ..| .|. . ..      ..| ..|||.||
grekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaG

LGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
.|||||.|..|.|     |. .... |.....| .|||.|  |.| 
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqy
0042113 (Phosphotyrosine protein) phosphatases II 167-321 6.3e-31 103.1 In-house 1-233 (245) alignment 
Range on Protein: 167-321
Range on HMM: 1-233/245.0
YEHYERVENGDFNWI----------------------------------VPNKYLAFSGPHPKskiengypyhAPEAYFPYFRKHNITSIVRLNKKIYD-
|......||.|.|..                                  ...|..|..||.|.           .|... ......||.||.|..  .. 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe..........tvedfwrmlwelgittivmLteeeelg

------------------------------------------ARRFTDAGFDHYDLFFIDGSTPS-DSILQKFLAISES-----SEGSLAVHCKAGLGRT
                                             ..  .. .. | . |...|. ...|..|| . ..     |.| ..|||.||.|||
rvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt

GTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQHY
||.|..|.|     |. .... |.....| .|||.|  |.| .
GtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyr
0036282 (Phosphotyrosine protein) phosphatases II 169-320 2.2e-30 101.0 In-house 3-159 (174) alignment 
Range on Protein: 169-320
Range on HMM: 3-159/174.0
HYERVENGDFNWIVPnKYLAFSGPHPkskiengypyhapeaYFPYFRKHNITSIVRLNKKIYDA------------RRFTDAGFDHYDLFFIDGSTPSDS
.|... . |...| | ...|..||..               .........||..|.|.. ...               ... |. ...| . |...|..|
dyinaspldlsyitp.rliagqgpla...............fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdls

ILQKFLAISESS-----EGSLAVHCKAGLGRTGTLIGCYIMKHFRF-TAAEVIAWMRICR---PGSVIGPQQH
||..|. . |.      .| ..|||.||.||||||...|.|..  . .. ......| .|   ||.|. |.| 
illefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQy
0046846 (Phosphotyrosine protein) phosphatases II 172-321 3e-29 97.4 In-house 6-163 (176) alignment 
Range on Protein: 172-321
Range on HMM: 6-163/176.0
RVENGDFNWIVPNKYLAFsgphpKSKIENGYPYHAPEAYFPYFRKHNITSIVRLNKK--------IYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLA
.....|...|..| .|       .  .  |  ..  .... ......|| .|.|..          ..  .....|. .. | . |...|....|...|.
lgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllelle

ISESSE---GSLAVHCKAGLGRTGTLIGCYIMKH-FRFTAAEVIAWMRICRP-GSVIGPQQHY
. ..     |  .|||.||.||||||. .|.... . ... |..|..| .|| |.|  |.| .
firealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyr
0037934 (Phosphotyrosine protein) phosphatases II 173-320 1.5e-30 102.0 In-house 34-231 (243) alignment 
Range on Protein: 173-320
Range on HMM: 34-231/243.0
VENGDFNWIVPNkYLAFSGPHPKskiengYPYHAPEAYFPYFRKHNITSIVRLNKKI------------------------------------------Y
  |... ...|. . |..||.|.         ....... .. ...||.|| |.. .                                          .
yinanliyvtpr.liatqgPlpe......tveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenl

DARRFTDAGFDHYDLFFIDGSTPS-DSILQKFLAI------------SESSEGSLAVHCKAGLGRTGTLIGCYIMKHF-RFTAAEVIAWMRICRPG-SVI
|.  .|  .. .. | . |...|.  ..|..|| .             ..|.| ..|||.||.||||||| .|.|..  .... |.....| .||| .| 
dlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavq

GPQQH
 |.| 
tpsqy
0048567 (Phosphotyrosine protein) phosphatases II 173-225 2e-07 25.5 In-house 2-59 (157) alignment 
Range on Protein: 173-225
Range on HMM: 2-59/157.0
VENGDFNWIVPNKYLAFSGPHPKSKIENGYPYHAPE--AYFPYFRKH---NITSIVRL
.||||...|.|........|.......| .... ..   |...|...   |.. ..|.
kengdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrF
0051082 (Phosphotyrosine protein) phosphatases II 177-323 3.6e-31 103.2 In-house 7-145 (151) alignment 
Range on Protein: 177-323
Range on HMM: 7-145/151.0
DFNWIVPNkYLAFSGPHPkskiengypyhapeAYFPYFRKHNITSIVRLNKKI---YDARRFTDAGFDHYDLFFIDGSTPSD----SILQKFLAISESS-
.|... .. .....||..              ..........|..|| |...    |........|...... ..| ..|.      ....|| . ..  
nfsyvtgg.lyrsggpla..............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkk

EGSLAVHCKAGLGRTGTLIGCYIMKhFRFTAAEVIAWMRICRPGSVIGPQQHYME
.| ..|||.||.||||||...|.|.  .....|.....|..|||.|. .||....
ngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfq
0051429 (Phosphotyrosine protein) phosphatases II 178-322 5.7e-19 64.3 In-house 16-216 (272) alignment 
Range on Protein: 178-322
Range on HMM: 16-216/272.0
FNWIVPNKYLAFSGPHPKSkiengypyhapEAYFPYFRKHNITSIVRLNKKIYDAR---RFTDAGFDHYDLFFIDGSTPSD-------------------
.....|..... .||.| .           .| |.......|..|| | .  . .|    .  .|.... | ..| |.|.                    
grvvkpgrlyrsggplplt...........aadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyi

---------------------------------SILQKFLAISESsEGSLAVHCKAGLGRTGTLIGCYIMKhFRFT--------------AAEVIAWMRI
                                 . | ..|..  . .| . |||.|| .||||.. ....   ...              ..|.....| 
lrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelra

CRPGSVIGPQQHYM
.|||.|  ..| ..
qrpgavqteeqylf
0046845 (Phosphotyrosine protein) phosphatases II 180-321 8.8e-23 76.5 In-house 73-264 (284) alignment 
Range on Protein: 180-321
Range on HMM: 73-264/284.0
WIVPNKYLAFSGPHPK-------------------------SKIENGYPYHAPEAYFPYFRKHNITSIVRLNKKIYDARRF-------TDAGFDHYDLFF
.....|..|..|| |.                          . |  ..|  .|  . .. .  .| . . .|. |  |..       |.  . .. . .
tyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhy

I---DGSTP-SDSILQKFLAISESS------EGSLAVHCKAGLGRTGTLIGCYIMKHF--------RFTAAEVIAWMRICRPGSVIGPQQHY
.   | ..| | ..|..|| . ...      .|  .|||.||.|||||.| ......         .... |.....| .|||.|  ..| .
tswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyr
0051299 (Phosphotyrosine protein) phosphatases II 181-320 3.9e-20 67.9 In-house 89-275 (288) alignment 
Range on Protein: 181-320
Range on HMM: 89-275/288.0
IVPNKYLAFSGPHPkskiengypyHAPEAYFPYFRKHNITSIVRLNKKI-------------------------------------------------YD
  ..|..|. || |          .  | .. .  ..|.. ||.|.| .                                                 .|
nlkrkfIatqgPlp..........ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgd

ARRFTDAGFDHYDLFfiDGSTPS-DSILQKFLAISESS----EGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
   .|   | ...    | ..|.  . | .|| .  ..    .|  .|||.||.|||||.| ....     |. .... |.....| .|||.|. |.| 
gesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqy
0049260 (Phosphotyrosine protein) phosphatases II 201-322 7.1e-32 105.6 In-house 16-141 (152) alignment 
Range on Protein: 201-322
Range on HMM: 16-141/152.0
GYPYHAPEAYFPYFRKHNITSIVRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAI-----SESSEGSLAVHCKAGLGRTGTLIGCYIMKhF
|.  .  . .. ......|| ||.|..  .... ... .. .. |.. |...|..|.| .|| .      ....|  .|||.||.||||||. .|.|. .
gpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.l

RFTAAEVIAWMRICRPGSVIGPQQHYM
.... |..|..| .|||.|. |.| . 
gvsleeavalvrekRpgavpnpgqlrf
subfamily_RNGTT_pd Subfamily RNGTT 208-324 1.1e-09 32.3 In-house 42-166 (189) alignment 
Range on Protein: 208-324
Range on HMM: 42-166/189.0
EAYFPYFR--KHNITSIVRLN--KKIYDARRFTDAGFDHYDLFFI-DGSTPSDSILQKFLAISES-----SEGSLAVHCKAGLGRTGTLIGCYIMKHFRF
.  . |..  |...  .. |   .. ||.. ... |  .  |     | .|.    ..|  . |.     .|  ..|||. |  ||| || .|....  .
smllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedw

TAAEVIAWMRICRPGSVIgpQQHYMEE
 . . .|  . .||  .   ...|..|
sveaavalFakaRppGiy..kedylke
subfamily_PRL_pd Subfamily PRL 209-327 1.1e-16 55.2 In-house 25-147 (151) alignment 
Range on Protein: 209-327
Range on HMM: 25-147/151.0
AYFPYFRKHNITSIVRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAI-----SESSEGSLAVHCKAGLGRTGTLIGCYIMKHfRFTAAEVI
 .   ..|......||  .  ||.. . ..| .  || | ||..|........|..     .|... ..|||| |||||.  |.   .. .  ..  . .
kfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyedav

AWMRICRPGSVIGPQQHYMEEKQA
 ..|  | |..   | ...|. .|
efirekrrgainskqlkflekyka
0048179 (Phosphotyrosine protein) phosphatases II 210-320 6.4e-26 86.2 In-house 21-134 (144) alignment 
Range on Protein: 210-320
Range on HMM: 21-134/144.0
YFPYFRKHNITSIVRLNKKiYDARRFTDAGFDHYDLFFIDGSTPSD-SILQKFLAISESS---EGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAW
 .....|..|| ...|. . |.   ... |. .. | . | ..|.. ..|..||.. |.    .|  .|||.||.||||||. .|.||...... |..|.
dlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealal

MRICRPGSVIGPQQH
.| .|||.|. |.| 
vrsrrpgavpnpgql
0048076 (Phosphotyrosine protein) phosphatases II 211-320 4.3e-25 83.5 In-house 22-132 (145) alignment 
Range on Protein: 211-320
Range on HMM: 22-132/145.0
FPYFRKHNITSIVRLnkkIYDARRFTDAGFDHYDLFFIDGSTPSD-SILQKFLAISESS---EGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWM
........|| ...|    .. . ... |. .. | . | ..|.. ..|..||.. |.    .|  .|||.||.||||||...|.|....... |.....
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelv

RICRPGSVIGPQQH
| .|||.|. |.| 
rsqrpgavpnpgql
0048567 (Phosphotyrosine protein) phosphatases II 214-330 1.4e-34 113.6 In-house 12-138 (157) alignment 
Range on Protein: 214-330
Range on HMM: 12-138/157.0
FRKHNITSIVRLNKKIYDARRF-TDAGFDHYDLFFIDGstPSD--------SILQKFLAISESSEGSLAVHCKAGL---GRTGTLIGCYIMKHFRFTAAE
. ... .. .||.|..|.|  | .|.|. ..|.|| .|  | .         .| ||| | |  .. .||||||||   |||.||||||...|..||..|
pdrlyfallprlpkslynalyFsiddglvyedfffdfG..PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpee

VIAWMRICRPGSVIGPQQHYMEEKQAAMW
.||..||.|||||......|.. ..  ..
aiaplrivrpgsvpfrdasyllslynltl
PTPc_motif_SM00404 216-324 1.5e-12 42.6 In-house 25-133 (140) alignment 
Range on Protein: 216-324
Range on HMM: 25-133/140.0
KHNITSIVRLNKKIY---DARRFTDAGFDhYDLFFIDGSTPSDSILQKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpg
|..|| .. . ...       .|.    .  |    |  ..  . . .|.  .|...|.  |||.||. |..||| .|.|.   ...||..  ..  |  
klgithvinvteevsltkensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR..

SVIGPQQHYMEE
. | |. .....
piispnlnfvrq
subfamily_DSP1_pd Subfamily DSP1 216-323 8.2e-08 26.5 In-house 41-147 (163) alignment 
Range on Protein: 216-323
Range on HMM: 41-147/163.0
KHNITSIVRLNKKIYDArrFTDaGFDHYDLFFIDgSTPSDsIL------QKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRIC
...|| |. . |.. ..  | |  | .. |   | |.  | |        .|.   ....| . .||.||. |  ||.  |.||. |..  |   ...  
slgitailnvskeldnv..fed.lfeYkklkleD.spkad.islvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqr

RpgSVIGPQQHYME
|  |.| |   .. 
R..siisPnagFvl
subfamily_DSP15_pd Subfamily DSP15 216-311 6.6e-07 23.5 In-house 25-120 (151) alignment 
Range on Protein: 216-311
Range on HMM: 25-120/151.0
KHNITSIVRLNKkiyDARRFTDAgfDHYDLFFIDGsTPSDSIL------QKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRIC
..||| |. ..    .|... .    .| .. ..  |||  .        .|.  . . |..  ||| ||. |  ||.  |.|    .   ...  .. .
eknithilsvhd...nakkllkd..ieYkciaasD.tpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaa

RP
| 
Rs
subfamily_PTPMT1_pd Subfamily PTPMT1 217-313 2.5e-11 38.3 In-house 45-151 (171) alignment 
Range on Protein: 217-313
Range on HMM: 45-151/171.0
HNITSIVRLNKKI------YDARRFTDAGFDHYDLFFIDGS-TPSDSILQK---FLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWM
.|. ..| ||.           ....  | ... |  .|   .|.   |.|   |.    |.  .. |||||| ||..||..||.||. ...  | .  .
envkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkal

RICRPGS
. .|.  
kkkRkii
subfamily_PTPRK_pd Subfamily PTPRK 218-293 9.8e-06 19.6 In-house 161-234 (314) alignment 
Range on Protein: 218-293
Range on HMM: 161-234/314.0
NITSIVRLNKKIYDARRFTDAGFDHYDLFFIDgsTPSDSILQKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMK
... . |  ..|   |.|   |. ..|       |   .....  . .| ..| . ||| || ||||| | . |. 
rveklargqeeirevrqfqflgWpdhdvPvsa..tgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl
subfamily_DSP3_pd Subfamily DSP3 223-322 3e-06 21.0 In-house 51-147 (162) alignment 
Range on Protein: 223-322
Range on HMM: 51-147/162.0
VRLNKKIYDARRFTDAGFDHYDLFFIDGSTPSDSILqKFLAIS-ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPgsvIGPQQHY
|  ... |.   ..  |..  | . .| |.  ..   ||.. . ...|| . |||..|. |  ||.  |.| . ..|. | |  .|  |    |.| . .
vdtgaefykdleikylGlevdDvpefdlskyFetaa.kfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe...ilPneGF

M
.
l
subfamily_DSP11_pd Subfamily DSP11 227-324 1.1e-08 29.1 In-house 67-169 (178) alignment 
Range on Protein: 227-324
Range on HMM: 67-169/178.0
KKIYDARRFTDAGFDHYDLFFIDGSTPSDSILQKFLAI-------SESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpGSVIGpQQ
.. |. . .|| |  .. |.    ..|.. ...|| .        .. ..  ..|||  |. ||| ||  |....  . . . |  .  .| |  .  ..
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear.Ghsle.re

HYMEE
.|...
nylkd
subfamily_PTEN_pd Subfamily PTEN 228-306 1.9e-09 32.8 In-house 71-152 (184) alignment 
Range on Protein: 228-306
Range on HMM: 71-152/184.0
KIYDARRFtDAGFDHYDlfFIDGSTPSDSILQKFLA-----ISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAA-EVIAWM
. ||...| |    .|.  | |  .|. ..|....      ..|...   .|||||| ||||.|| .|..|.  .. | |.... 
rkydskkf.dgrvavyp..fdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelf
subfamily_PTPDC1_pd Subfamily PTPDC1 230-319 8.3e-15 49.7 In-house 73-164 (182) alignment 
Range on Protein: 230-319
Range on HMM: 73-164/182.0
YDARRFTDAGFDHYDLFFIDGSTPS-DSILQKFLAIS-ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPGSVIGPQQ
||   ....|  .| . . | ...| ..||.    ..   .|| .|||| ||||||| || ||.. . |.||.. |  .|  || |.   .|
YdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreq
subfamily_DSP23_pd Subfamily DSP23 253-319 4.9e-14 47.2 In-house 65-134 (148) alignment 
Range on Protein: 253-319
Range on HMM: 65-134/148.0
PSDSILQKFLAISESS---EGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPGSVIGPQQ
|.   ...|. . | .   . ...|||  | |||||.. ||..|. ...||| || .|  |||||   .|
paleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveq
PTPc_DSPc_SM00012 255-310 2e-08 29.7 In-house 20-86 (105) alignment 
Range on Protein: 255-310
Range on HMM: 20-86/105.0
DSILQKFLAISESSE-----GSLAVHCKAGLGRTGTLIGCYIMKHFRFTAA------EVIAWMRICR
||||. . |. .. .     ... |||.|| |||||..  .|. .   .        ...  .|  |
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqR
DSPc_SM00195 255-320 2.5e-07 25.6 In-house 178-251 (263) alignment 
Range on Protein: 255-320
Range on HMM: 178-251/263.0
DSILQKFLAISESS---EGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
.|.|. . |. .|.   .| . |||.||.|||||..   |.     .....   |..  .|  |||.|   .|.
ksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqY
PTPc_SM00194 255-320 2.5e-07 25.6 In-house 178-251 (263) alignment 
Range on Protein: 255-320
Range on HMM: 178-251/263.0
DSILQKFLAISESS---EGSLAVHCKAGLGRTGTLIGCYIM-----KHFRFTAAEVIAWMRICRPGSVIGPQQH
.|.|. . |. .|.   .| . |||.||.|||||..   |.     .....   |..  .|  |||.|   .|.
ksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqY
DSPc Dual specificity phosphatase, catalytic domain 258-323 1.1e-12 42.9 Pfam-A 62-125 (133) alignment 
Range on Protein: 258-323
Range on HMM: 62-125/133.0
LQKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpgSVIGPQQHYME
. .|..  |..... .|||.||. |..||| .|.|| ..... | .. ..  |  | | |. ... 
avefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..skispnagflr
DSPc Dual specificity phosphatase, catalytic domain 258-323 1.1e-12 42.9 In-house 62-125 (133) alignment 
Range on Protein: 258-323
Range on HMM: 62-125/133.0
LQKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpgSVIGPQQHYME
. .|..  |..... .|||.||. |..||| .|.|| ..... | .. ..  |  | | |. ... 
avefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..skispnagflr
subfamily_DSP19_pd Subfamily DSP19 259-321 1e-07 26.4 In-house 79-139 (152) alignment 
Range on Protein: 259-321
Range on HMM: 79-139/152.0
QKFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPgsVIGPQQHY
..|.  . |..| . |||.||  |. ...  |.||. . .  | .  .|  ||   | | . .
ldFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearp..cikPneGF
subfamily_PTPN6_pd Subfamily PTPN6 259-288 7.8e-06 20.1 In-house 217-246 (306) alignment 
Range on Protein: 259-288
Range on HMM: 217-246/306.0
QKFLAISESSEGSLAVHCKAGLGRTGTLIG
.|   ..|...|.. ||| ||.|||||.| 
rkqeeleeaeagpivvhCsaGiGRtGtfiv
Y_phosphatase Protein-tyrosine phosphatase 260-318 1.5e-06 23.2 Pfam-A 157-224 (235) alignment 
Range on Protein: 260-318
Range on HMM: 157-224/235.0
KFLAIS----ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRF-----TAAEVIAWMRICRPGSVIGPQ
...       |...|.. |||.|| |||||..   |. .           ...  .| .|||.|   .
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsle
Y_phosphatase Protein-tyrosine phosphatase 260-318 1.5e-06 23.2 In-house 157-224 (235) alignment 
Range on Protein: 260-318
Range on HMM: 157-224/235.0
KFLAIS----ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRF-----TAAEVIAWMRICRPGSVIGPQ
...       |...|.. |||.|| |||||..   |. .           ...  .| .|||.|   .
dlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsle
subfamily_Slingshot_pd Subfamily Slingshot 260-326 1.8e-06 21.4 In-house 87-151 (169) alignment 
Range on Protein: 260-326
Range on HMM: 87-151/169.0
KFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpgSVIGPQQHYMEEKQ
||.  . ... .. |||| |. |. . .  | ||.....  | .....  |  ||| | . ...  .
kfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerr..svikPnkgflkqle
subfamily_DSP8_pd Subfamily DSP8 260-319 3.8e-06 20.5 In-house 84-141 (159) alignment 
Range on Protein: 260-319
Range on HMM: 84-141/159.0
KFLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRpgSVIGPQQ
.|.    |..|.  ||. ||  |  |.. .||||.....  |   ...  |   .| |. 
efidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr..ptispnl
subfamily_DSP12_pd Subfamily DSP12 261-311 2.8e-06 21.8 In-house 74-124 (155) alignment 
Range on Protein: 261-311
Range on HMM: 74-124/155.0
FLAISESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRP
|.  . . ||.. |||.||. |  |..  |.||. ..   . .  ..  .|
FieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp
subfamily_PTPN13_pd Subfamily PTPN13 264-327 2.5e-06 22.0 In-house 197-264 (273) alignment 
Range on Protein: 264-327
Range on HMM: 197-264/273.0
ISESSEGSLAVHCKAGLGRTGTLIGCYI-----MKHFRFTAAEVIAWMRICRPgSVIGPQQHYMEEKQA
  ....| ..||| ||.||.||||  ..      .   |   |..  .|  |  .|.  .. |.   .|
rlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrq.gvvqtkdqyifvyka
subfamily_DSP10_pd Subfamily DSP10 266-322 7.2e-08 26.5 In-house 89-143 (159) alignment 
Range on Protein: 266-322
Range on HMM: 89-143/159.0
ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPgsVIGPQQHYM
 ... .. |||.||. |  |..  |.|||.. .  .   ... .||  .| |   .|
rkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp..iisPnLnfm
subfamily_DSP14_pd Subfamily DSP14 266-317 2.6e-06 21.5 In-house 80-129 (157) alignment 
Range on Protein: 266-317
Range on HMM: 80-129/157.0
ESSEGSLAVHCKAGLGRTGTLIGCYIMKHFRFTAAEVIAWMRICRPgsVIGP
. ..|   |||.||  |  .|   |.||. . . .|   ... .||  .| |
kkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRp..iirP