Gene SpurDSP-Un-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP007_AA protein Get Run
SpurP007_AA_164-324 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PTEN_1 151-323 2e-10 35.8 In-house 24-192 (196) alignment
Range on Protein: 151-323
Range on HMM: 24-192/196.0
IIPEIKIDKTLYKDQNVT-EILDFLYMGDLEAANR-EPLLCRLNIEYIIDLSNLSGEqvkrtirlKDCPCLCASTMKHTRIRLNLHLDETVGDGISHYFD
.|..  |...   ..... || ..||.| |. . .    |   .|  ...||. . .        . ...   . .|.  . |... .      .|. ||
yitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel........sgrsydleeffksgveylhfpieDhgapslselfd

EVNRFIEGARK--SNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLR
....||| ...  ... ||..|  ||    |.   |... ...| ..|  .. .  | . .. ..|..|.. ...|.
icksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell

0044763 (Phosphotyrosine protein) phosphatases II 155-324 2e-21 71.9 In-house 11-172 (178) alignment
Range on Protein: 155-324
Range on HMM: 11-172/178.0
IKIDKTLYKDQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLSgeqvkrtiRLKDCPCLCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFI
   .   .   |..|||..||.|.| .|.  .||..|.| .|..|..          .|  ..|.    ...    |.....      .. .|.|. .||
nleglersdyinaseilpglylgslppaddlellkelgithivnlteel........elgflkcdpywpeeagiqylhipipDhgvpdllehflefvefi

EGAR-KSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPeVTFREGFQRALIRLEQNLRP
| |. .....||..|  |.  ..|.   |.. ..|..| .|  .. . .| .  ..|..| |...|. |..
eealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk

0041856 (Phosphotyrosine protein) phosphatases II 161-321 5.7e-13 44.3 In-house 17-171 (182) alignment
Range on Protein: 161-321
Range on HMM: 17-171/182.0
LykdqNVTEILDFLYMGDLEA--------------ANREPLLCRLNIEYIIDLSnlsgeqvkrtirlkdcpC--LCASTMkhTRIRLNLHLDETVGDGIS
.    . ..|.. ||.|.| |              |.  ..| .|.| .|..|.                 .    ..    .|  ....     ..|. 
r....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.................eelywpell..erlgiqylylpwpDhgvp

HyFDEVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKP--EVTFREGFQRALIRLEQN
  .||...||| .......||. |  |.  ..|.   |.. ..|..| .|  .. . .|   .|   .| . |. ||  
d.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_DSP10_pd Subfamily DSP10 162-325 1.5e-20 67.7 In-house 9-156 (159) alignment
Range on Protein: 162-325
Range on HMM: 9-156/159.0
YKDQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgeqvkrtirlkDCPCLCAS-TMKHTRIRLNlhldETVGDGISHYFDEVNRFIEGARKS
.. ......| ||..|. . |. . .| ||||...... .             ..|.  .  ..|. || ..    .|    ...||.|   ||| |||.
ietapasqvlpfLflGsekdaadldaldrlnitavlnvtt.............svPnefeeealkYkripvs....Dtskqnlkqyfeealefieearkk

NRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLRPK
..|||..|  |.  . |..  |... ....|..|. .. . .| ..   .|   |...|..|. .
gsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks

subfamily_DSP1_pd Subfamily DSP1 162-323 2.4e-17 57.5 In-house 14-157 (163) alignment
Range on Protein: 162-323
Range on HMM: 14-157/163.0
YKDqNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgeqvkrtirlkDCPCLCASTMKHTRirlnLHLDETVGDGISHYFDEVNRFIEGARKSN
  |  |..||||||.|  . | .  .| .|.|  |...|.             ...  . ..... .    |.|...  . || .|.||  ||. ..|.|
lyd.PvekildfLylGsetvasnleiLkslgitailnvsk.............eldnvfedlfeYkk....lkleDspkadislvfeeviefidevkkkn

RRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLR
 .|||.| .|.  . |.   |...   ..|..|.  . . .. .    ||.. |.. |..| 
GkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll

subfamily_DSP19_pd Subfamily DSP19 162-322 9.2e-17 55.8 In-house 7-150 (152) alignment
Range on Protein: 162-322
Range on HMM: 7-150/152.0
YKDQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSnlsgeqvkrtirlKDCPCLCASTMKHTRIRLnlhLDETvGDGISHYFDEVNRFIEGARKSN
 .| .|.|. . ||.|  ..|. .  | . .| .|....              . |.. .. .. . | .   ||.     ...|..|.  ||| ||...
kedlevgeveprlylgsqdvaadkeilkekkitHilnva.............tgvpnvfpkdftylsiei...lDlp.etdllsylkealdFieearskd

RRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
 .||. |  |   ....   |...   ..|..|   . ...| ..  |||.. | ..|..|
gavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael

0046846 (Phosphotyrosine protein) phosphatases II 162-323 3e-12 42.1 In-house 7-173 (176) alignment
Range on Protein: 162-323
Range on HMM: 7-173/176.0
YKDQNVTEILDFLYMGDLE----------AANREPLLCRLNIEYIIDLSNLSGEQVKRtirlkdCPCLCASTMKHTRIRLNLHLDETVGDGIsHYFDEVN
. | ....|.. |..|..            |.   .| .|.|.....| ..   .  .      || ..   .|.    |.|. ..     .  ...|. 
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlk......cpnywpeleklgiqylhlpwpDhgvpdl.elllell

RFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQV-MGMTLKQAHGHITKIKP-EVTFREGFQRALIRLEQNLR
.||. |.|....||. |. |.  ..|.   |...  .|... .|  .. ...|  .   ... | | . |. |.
efirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll

subfamily_DSP6_pd Subfamily DSP6 164-323 2.8e-15 50.2 In-house 11-155 (158) alignment
Range on Protein: 164-323
Range on HMM: 11-155/158.0
DQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgeQVKRTIRLkdcpclcASTMKHTRIRLNLHLDetvgDGISHYFDEVNRFIEGARKSNRR
..   |||..||.|  ..|.   .| .|.|.|.... .    ..  . .        .  .|...| .. ||       ....| |  .||. ||...  
aefpveilpllylGsakdasnlevlkklkikyvlnvts....nlpnkfee.......sgelkylqipiedhls....qnlakffPeaiefidearskksk

VLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLR
||..| .|.  . |.|  |... . ..|..|.  . | |....    |   |.  |..||
vlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr

subfamily_DSP8_pd Subfamily DSP8 164-323 4.3e-15 49.6 In-house 12-155 (159) alignment
Range on Protein: 164-323
Range on HMM: 12-155/159.0
DQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgeqvkrtiRLKDCPCLCASTmkHTRIRLNlhldETVGDGISHYFDEVNRFIEGARKSNRR
| ..|.||..||.|  . .  | || .|.|.|.. .||             .  .|. |     |. ..    ..  . .. .||.   ||. |...| |
dvgptrilknlylGsqkdvlseellsklgisyvlnasn..........scpkleelkesk..flrvPvk....Dkydekllpwfdksvefidkaksengr

VLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLR
||... .|   ..|.   |... . |.| .|. .. . .| .     |.  |.  |..|.
vlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk

subfamily_DSP3_pd Subfamily DSP3 164-325 5.8e-14 46.0 In-house 8-160 (162) alignment
Range on Protein: 164-325
Range on HMM: 8-160/162.0
DQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEQVKRTIRL-KDCPclcastmkhtrIR-LNLHLDETVGDGISHYFDEVNRFIEGARKS-
 ..| |. . ||.|| ..|. .  | .| | .... .. .  .|.      ||             |. | |..|..    .|.||... .||. | .. 
skevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdle...........ikylGlevdDvpefdlskyFetaakfidealsqk

NRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKiKPEVTFREGFQRALIRLEQNLRPK
. .||. ||.|.  ..|.   |.. .  |||..|  .. | | |..  ||| . |. |...|. |
egkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrk.kReilPneGFlkqLaeldeelkrk

0036282 (Phosphotyrosine protein) phosphatases II 165-320 5.6e-09 31.4 In-house 10-167 (174) alignment
Range on Protein: 165-320
Range on HMM: 10-167/174.0
QNVTEILDFLYMGDLEAAnREPLLCRLNIEYIIDLSNLSGEQVKRTIRLKDCpcLCASTMKHTRIRLNLHLDETVGDGISHyFDEVNRFIEGARKS--NR
 ....|.. |. |.  .|   ..|..|.|.....| ..   .  . |..     |  .  ..    | |. .      .|  ..|. .|.| |...  ..
ldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpe..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpgg

RVLIYCVTGLILAPTITTQYMIQVMGM-TLKQAHGHITKIK---PEVTFREGFQRALIRLEQ
 ||. |  |.  ..|.   |.. .... .| .|  .. ...   | .  .... | |  .|.
pvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek

subfamily_DSP14_pd Subfamily DSP14 166-327 2.6e-19 63.7 In-house 6-149 (157) alignment
Range on Protein: 166-327
Range on HMM: 6-149/157.0
NVTEILDFLYMGdLEAANREPLLCRLNIEYIIDLSNlsgEQVKrtIRLKDCPclcastmkhtriRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVL
....| . |...   ||... || . .|  ||...    |...   .|||              |... ....    ....||||   || ..|.. ..|
alsqitpsLfls.gvaalskellkkkkitliinvtv...elpn..tklkdie............rvkvpveDnpeaklakhfdevadkieevkkkggktl

IYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLRPKAA
..||.|     .... |...   ..|..|. .. ...| .    || . ||..|..|. |..
vhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkss

0048076 (Phosphotyrosine protein) phosphatases II 166-322 2.7e-16 55.0 In-house 3-142 (145) alignment
Range on Protein: 166-322
Range on HMM: 3-142/145.0
NVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLsnlsgeqvkrtirlkdcPCLCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVL
...|||. || |.| .|.. .||..|.| ....|                  . .    ..    |.| ..      .. ...|. .||| |.|....||
wpseilpglylgslptaldlellkdlgittvlnl.................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvl

IYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
..|  |.  ..|.   |..  .|..| .|  .. .  | .  ..|..| |...|. |
VHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 166-320 3.8e-15 51.4 In-house 3-142 (144) alignment
Range on Protein: 166-320
Range on HMM: 3-142/144.0
NVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlSGEQVKRTIRlkdcpclcastmkhTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVL
|..|||. ||.|.| .|.. .||..|.| ..|.|.. . |.   .                    |.| ..      ......|. .||| |......||
npseilpglylgslptaldlellkklgittvinlte.eyepeflere..............giqylhlpwpDhgvpdllellleflefieealeeggpvl

IYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
..|  |.  ..|. . |.. ..|..|..|  .. .. | .   .|. | |...|.
VHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek

0051082 (Phosphotyrosine protein) phosphatases II 166-305 7.2e-10 34.2 In-house 7-136 (151) alignment
Range on Protein: 166-305
Range on HMM: 7-136/151.0
NVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEQvkrtirlkDCPCLCAS-TmkhtRIRLNLHLDETVGDGISHYFDEVNRFIEGARKS-NRR
| . . ..|| ..   |   .|| .|.| .|..| ..   .         ||... .      .  |..... .   |....||.|..|.| ...  |  
nfsyvtgglyrsggpladflellkelgiktivnlrseeerg........ycpeylpelg....ievlhipildwpdpglplsfdavleflellldkkngp

VLIYCVTGLILAPTITTQYMIQvMGMTLKQAHGHITKIKP-EV
||..|  |.    |.   |..  .|..| .|  .. .. |  |
vlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvv

subfamily_Slingshot_pd Subfamily Slingshot 166-319 8.6e-10 32.3 In-house 18-154 (169) alignment
Range on Protein: 166-319
Range on HMM: 18-154/169.0
NVTEILDFLYMGD-LEAANREPLlCRLNIEYIIDLSnlsgeqvkrtirlKDCPCLCASTMKHTRIRLNlhlDETVgDGISHYFDEVNRFIEGARKSNRRV
. ..| |..|.|   .|.| | |  . ..|||....             |..    . ......||.    ||   . . .|..|  .||| |.|.. .|
saskifdhvylGsewnasnleel.kengveyilnvt.............keidnffpekfeylnirvy...deee.tdllkywnetykfiekakkkgskv

LIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLE
|..|  |.  . ..   | ..  |..|..|. .. . .  .   .|| . |   |
lvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeye

PTPc_motif_SM00404 167-320 4.8e-21 70.1 In-house 2-139 (140) alignment
Range on Protein: 167-320
Range on HMM: 2-139/140.0
VTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEQvkrtirlkdcpclcasTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLI
...||. ||.| ...|....||  |.|...|....    .                  .  . .|.. ||..  | .|.|.|.|..||| |.|....||.
psrilphlylgskskaqnpallkklgithvinvteevslt................kensgfqilqiplddnekdklskyldkvldfienaekkggkvlV

YCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
.|  |.    |... |... ....|..|   . . .| .  ...| | || .|.
HCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

subfamily_DSP12_pd Subfamily DSP12 167-315 3.2e-16 54.1 In-house 2-136 (155) alignment
Range on Protein: 167-315
Range on HMM: 2-136/155.0
VTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgEQVkrtirlkdcPCLC--ASTMKhtriRLNLHL-DETVGDgISHYFDEVNRFIEGARKSNRR
|..||. ||.|.|||...|.||  |.|. .. . .   |..         |     .....    ...... ||   | | ...||...||| |.. .. 
vsrilpglylggleavqeeellkelkithvlsvik...eel.........pehklkkgkvs....tkfiqilDepeed.iLshldeavdFieealeeega

VLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRAL
||. |  |.    || . |...  .. |..|.  . ..|||..  |||.. |
vlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQL

subfamily_DSP15_pd Subfamily DSP15 167-319 2.7e-14 47.5 In-house 2-136 (151) alignment
Range on Protein: 167-319
Range on HMM: 2-136/151.0
VTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgeqvkrtirlkdcpclCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLI
....|  ||.|... .. | || . ||  |. ...                   |  . .    . .....| .  .|..|.| ..||  .|  .  ||.
iskvlpglylgnfrdskdeelLkeknithilsvhd..................nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlv

YCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLE
.|. |.  . |... |.. |. .  ..|   | . .       ||.| |   |
hClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeye

0043147 (Phosphotyrosine protein) phosphatases II 167-322 1.6e-11 39.7 In-house 19-160 (172) alignment
Range on Protein: 167-322
Range on HMM: 19-160/172.0
VTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLsgeqvkrtirlkdcPCLCASTMKHTRIRLNLHLDETVGDgISHYFDEVNRFIEG--ARKSNRRV
 ...........   |    .| .|.| .|..| .|               ...   ...    | |  .      .. ...|. .||.   |.... .|
pdrfiatqgplrntladfwrmlkelgithivnltel..............lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpv

LIYCVTGLILAPTITTQYMIQvMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
|. |. |.  ..|.   |... .|..| .|  .. . .| .   ....| |  .|. |
lVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll

0042113 (Phosphotyrosine protein) phosphatases II 167-321 4.2e-07 25.1 In-house 47-241 (245) alignment
Range on Protein: 167-321
Range on HMM: 47-241/245.0
VTEILDFLYMGDLEAANREP----LLCRLNIEYIIDLSNLSGEQV--------------------------------KRTIRLKDCPCLCastmkhTRIR
. .| . .....  ...  .    .| .|.|..|..|...   .                                  ||..... .. .      .|  
gyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgdde......srev

LNLHLDETVGDG---ISHYFDEVNRFIEGARK--SNRRVLIYCVTGLILAPTITTQYMI-----QVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
...|     ..|   .. ..... .|.. |..  || .||. |  |.  . |. . |..       .|..| .|  .. . .| .   ... | |.....
ihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

N
.
e

subfamily_LRR-DSP_pd Subfamily LRR-DSP 168-322 1.5e-14 47.7 In-house 121-258 (263) alignment
Range on Protein: 168-322
Range on HMM: 121-258/263.0
TEILDFLYMGDLEAANREPLLCRLNIEYIIdlsnlsgeqvkrtIRLKDCPCLCASTMKHTRIRlnlHLDETVGDGISHYFDEVNRFIEGARKSNrRVLIY
 ||.| |..| |..|| ...|  |.. .|.             . . |.  |   ..|.  |    .....    || .|.|.| |||  ||.   ||..
deiidklflGgldsannksilkdlgvthil.............lavadfePlfPklfkylsid...diedvdeadisqhfeetnafieeGrkkG.Gvlvh

CVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
| .|.  . |..  |...   ...|.|   . | .|..    ||.  | . |..|
craGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl

0049260 (Phosphotyrosine protein) phosphatases II 168-320 4.4e-09 31.7 In-house 9-147 (152) alignment
Range on Protein: 168-320
Range on HMM: 9-147/152.0
TEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEQVKRTIRLKdcpclcastmkhtrIRLNLHLDETVGDGISHYFDEVNRFIEG-ARKSNRRVLI
.|.. ....|.  .|.   .| .|.| .|. | .|.      . ..                 |.|  .      .| .......|||  |.... .||.
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlV

YCVTGLILAPTITTQYMIQvMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
 |. |.  ..|.   |..  .|..|..|  .. . .| .   .|. | |   |.
HCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek

0040439 (Phosphotyrosine protein) phosphatases II 169-321 6e-09 31.4 In-house 31-244 (249) alignment
Range on Protein: 169-321
Range on HMM: 31-244/249.0
EILDFLYMGDLEAANREPL------------------------LCRLNIEYIIDLSNLSGE--------------------------------QVKRTIR
.||. |. .|   |.  ..                        | .|.|..|..|..|                                    . ||..
silpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtle

LKDCpclcasTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARK------SNRRVLIYCVTGLILAPTITTQYMI-----QVMGMTLKQAHGHITKI
|..         . .|  | ..      .|.. .|... .||| .||      .. .||. |  |.  ..|. . |..        |..|..|  .. . 
ltnl......ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsq

KPEVTFREGFQRALIRLEQN
.| .   ... | |..... 
Rpgavqnpeqyrflyealle

subfamily_STYXL1_pd Subfamily STYXL1 172-322 3.4e-09 30.1 In-house 17-153 (157) alignment
Range on Protein: 172-322
Range on HMM: 17-153/157.0
DFLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEqvkrtirlkdcpclCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTG
..||.|. . |  . .   | .   ...|. ...                ......   |.......    . . ..|. .|||  .|... ||..   |
gklylGnykqaqnpaikkdlkvkahvnvsmdadk..............liagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkG

LILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
.  . ..   |..    .|||.|. .. | |. |  . .|   | . |..|
isrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 173-321 5.6e-11 36.2 In-house 14-146 (148) alignment
Range on Protein: 173-321
Range on HMM: 14-146/148.0
FLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEQVKRTirlkdcpclcastmkhtRI-RLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTG
||..|. . |     |  |..  |.. ..     .                     |  |.. ||.     .| .|...  |.. |..  ||||. .  |
fLFlGskksaadlealkalgvtrivnatkerdnaldqr.................gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmG

LILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQN
   .  ..  ..|.   ..||.|   .   .. |  . || . |  |||.
vsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqa

DSPc Dual specificity phosphatase, catalytic domain 174-320 8.4e-17 56.3 Pfam-A 1-132 (133) alignment
Range on Protein: 174-320
Range on HMM: 1-132/133.0
LYMGDLEAANrEPLLCRLNIEYIIDLSNLSGEQvkrtirlkdcpclcASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTGLI
||.|  ..|. ..||  |.|...|....   ..               .  |  . .|.. ....  . || ...|. .||| |......||..|  |. 
lylgskstas.lalleklgitlvinvtkevpnn..............naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGis

LAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
  .|... |... ....|..|  .. . .. .  ..||.| |. .|.
RSatliiaYlmktknlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 174-320 8.4e-17 56.3 In-house 1-132 (133) alignment
Range on Protein: 174-320
Range on HMM: 1-132/133.0
LYMGDLEAANrEPLLCRLNIEYIIDLSNLSGEQvkrtirlkdcpclcASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTGLI
||.|  ..|. ..||  |.|...|....   ..               .  |  . .|.. ....  . || ...|. .||| |......||..|  |. 
lylgskstas.lalleklgitlvinvtkevpnn..............naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGis

LAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
  .|... |... ....|..|  .. . .. .  ..||.| |. .|.
RSatliiaYlmktknlslneAyefvkerrskispnagflrqLleyer

0045450 (Phosphotyrosine protein) phosphatases II 187-321 1.3e-08 30.5 In-house 126-302 (307) alignment
Range on Protein: 187-321
Range on HMM: 126-302/307.0
LLCRLNIEYIIDLSNLSGE---------------------------------QVKRTIRLKDCpclcaSTMKHTRIRLNLHLDETVGDGISHYFDEVNRF
.| ......|..|..|                                     . ||....|.     .  . .|.   .|  .  ..|.. .|.|. .|
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.....dgtgesrtvthfhytgwpdhgvppsfeelldf

IEGARK------SNRRVLIYCVTGLILAPTITTQYMIQVMG--------MTLKQAHGHITKIKPEVTFREGFQRALIRLEQN
|| .||      .. .||. |  |.  ..|. . |.. ...        ..| .|  .. . .| .   ... | |..... 
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

0038934 (Phosphotyrosine protein) phosphatases II 190-329 1e-09 33.8 In-house 40-183 (194) alignment
Range on Protein: 190-329
Range on HMM: 40-183/194.0
RLNIEYIIDLSNLSGEQVKRTIRLK------DCPCLCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIegARKSNRRVLIYCVTGLILAPTITTQYM
|...| .... .| ....   |.|       |.  . .. ... ..    .      . . ...| |..|.  .....  |.. |. ||  ..|.   |.
rfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYL

IQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLRPKAALP
|...||....| .... ..| .  . .. .|| .  ..||...  |
iyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlap

0040438 (Phosphotyrosine protein) phosphatases II 190-322 7.6e-06 20.9 In-house 108-275 (317) alignment
Range on Protein: 190-322
Range on HMM: 108-275/317.0
RLNIEYIIDLSNLSGEQ--------------------------------VKRTIRLKDCPCLcastmkHTRIRLNLHLDETVGDGISHYFDEVNRFIEGA
......|. | .|   .                                . ||....|  .        .|.   .|      .|.  ..|.. .|.| .
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgds......esrtvthfhytgWpdhgvppspdllldfleav

RKS----NRRVLIYCVTGLILAPTITTQYMI-----QVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
|..    .  ||. |. |.  . |. . |..     . .|.....|  .. . .| .   ... | |.......
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley

0049772 (Phosphotyrosine protein) phosphatases II 197-322 1.6e-10 36.7 In-house 161-273 (314) alignment
Range on Protein: 197-322
Range on HMM: 161-273/314.0
IDLSNLSgeqvkrtirlkD-C--PCLCAST-MKHTRIrlnlHLDETVGDgISHYFDEVNRFIEGArKSNRRVLIYCVTGLILAPT-ITTQYMIQVMGMTL
 || .|            . .  | |.  . .|. ||    ...    . .. .|||. .||| | . ...||. |  |   ..| ... |..  .|..|
adlellk...........eelydpelferlgikylri....pvpDgsap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsl

KQAHGHITKIKPeVTFREGFQRALIRLEQNL
..|  .. .. | .  ..|| . |...|. |
eealedvrlkRp.inpnpgfieqleqyefil

subfamily_STYX_pd Subfamily STYX 219-319 5e-07 23.0 In-house 54-154 (166) alignment
Range on Protein: 219-319
Range on HMM: 54-154/166.0
LCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRL
|    ....   | | . ... . |  |. .|  ||... ..  .||..  .|.  . ..   |... .|.  ..|. .. . .  ..  ||| . |   
likpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkey

E
|
e

subfamily_MKPLT_pd Subfamily MKPLT 230-320 1.1e-10 35.3 In-house 68-158 (164) alignment
Range on Protein: 230-320
Range on HMM: 68-158/164.0
RLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
 |........ . .| ... .. |.  | .|  |||..|| |   . ..| ...|.  | |||.|. .. . .  |.   || . | . |.
YlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_MKPLV_pd Subfamily MKPLV 230-320 1.1e-10 35.3 In-house 68-158 (164) alignment
Range on Protein: 230-320
Range on HMM: 68-158/164.0
RLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
 |........ . .| ... .. |.  | .|  |||..|| |   . ..| ...|.  | |||.|. .. . .  |.   || . | . |.
YlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 241-323 3e-08 26.9 In-house 60-142 (145) alignment
Range on Protein: 241-323
Range on HMM: 60-142/145.0
DGISHYFDEVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLR
  .| .||||  ||.  ..    |...|..|.  . |..  ....  .||| .|   .   .        | ..|..||..|.
ydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlk

0048567 (Phosphotyrosine protein) phosphatases II 243-305 2.2e-06 22.2 In-house 56-121 (157) alignment
Range on Protein: 243-305
Range on HMM: 56-121/157.0
ISHYFDEVNRFIEGARKSNRRVLIYCVTGL---ILAPTITTQYMIQVMGMTLKQAHGHITKIKPEV
. ...  .|.|..  .. .... ..| .||     . |.   |.| ..|.|  .| ...  . |  
lyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgs

subfamily_PTPMT1_pd Subfamily PTPMT1 249-322 4.3e-07 24.5 In-house 95-168 (171) alignment
Range on Protein: 249-322
Range on HMM: 95-168/171.0
EVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
.  .|||  ... .|| . | .|   . |. . |...   .....|. .. |... .  ..  ..|| . |..|
kgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl