Gene SpurDSP-Un-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP007_AA protein Get Run
SpurP007_AA_164-324 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PTEN_1 151-323 2e-10 35.8 In-house 24-192 (196) alignment 
Range on Protein: 151-323
Range on HMM: 24-192/196.0
IIPEIKIDKTLYKDQNVT-EILDFLYMGDLEAANR-EPLLCRLNIEYIIDLSNLSGEqvkrtirlKDCPCLCASTMKHTRIRLNLHLDETVGDGISHYFD
.|..  |...   ..... || ..||.| |. . .    |   .|  ...||. . .        . ...   . .|.  . |... .      .|. ||
yitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel........sgrsydleeffksgveylhfpieDhgapslselfd

EVNRFIEGARK--SNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLR
....||| ...  ... ||..|  ||    |.   |... ...| ..|  .. .  | . .. ..|..|.. ...|.
icksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0044763 (Phosphotyrosine protein) phosphatases II 155-324 2e-21 71.9 In-house 11-172 (178) alignment 
Range on Protein: 155-324
Range on HMM: 11-172/178.0
IKIDKTLYKDQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLSgeqvkrtiRLKDCPCLCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFI
   .   .   |..|||..||.|.| .|.  .||..|.| .|..|..          .|  ..|.    ...    |.....      .. .|.|. .||
nleglersdyinaseilpglylgslppaddlellkelgithivnlteel........elgflkcdpywpeeagiqylhipipDhgvpdllehflefvefi

EGAR-KSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPeVTFREGFQRALIRLEQNLRP
| |. .....||..|  |.  ..|.   |.. ..|..| .|  .. . .| .  ..|..| |...|. |..
eealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
0041856 (Phosphotyrosine protein) phosphatases II 161-321 5.7e-13 44.3 In-house 17-171 (182) alignment 
Range on Protein: 161-321
Range on HMM: 17-171/182.0
LykdqNVTEILDFLYMGDLEA--------------ANREPLLCRLNIEYIIDLSnlsgeqvkrtirlkdcpC--LCASTMkhTRIRLNLHLDETVGDGIS
.    . ..|.. ||.|.| |              |.  ..| .|.| .|..|.                 .    ..    .|  ....     ..|. 
r....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.................eelywpell..erlgiqylylpwpDhgvp

HyFDEVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKP--EVTFREGFQRALIRLEQN
  .||...||| .......||. |  |.  ..|.   |.. ..|..| .|  .. . .|   .|   .| . |. ||  
d.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_DSP10_pd Subfamily DSP10 162-325 1.5e-20 67.7 In-house 9-156 (159) alignment 
Range on Protein: 162-325
Range on HMM: 9-156/159.0
YKDQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgeqvkrtirlkDCPCLCAS-TMKHTRIRLNlhldETVGDGISHYFDEVNRFIEGARKS
.. ......| ||..|. . |. . .| ||||...... .             ..|.  .  ..|. || ..    .|    ...||.|   ||| |||.
ietapasqvlpfLflGsekdaadldaldrlnitavlnvtt.............svPnefeeealkYkripvs....Dtskqnlkqyfeealefieearkk

NRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLRPK
..|||..|  |.  . |..  |... ....|..|. .. . .| ..   .|   |...|..|. .
gsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
subfamily_DSP1_pd Subfamily DSP1 162-323 2.4e-17 57.5 In-house 14-157 (163) alignment 
Range on Protein: 162-323
Range on HMM: 14-157/163.0
YKDqNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgeqvkrtirlkDCPCLCASTMKHTRirlnLHLDETVGDGISHYFDEVNRFIEGARKSN
  |  |..||||||.|  . | .  .| .|.|  |...|.             ...  . ..... .    |.|...  . || .|.||  ||. ..|.|
lyd.PvekildfLylGsetvasnleiLkslgitailnvsk.............eldnvfedlfeYkk....lkleDspkadislvfeeviefidevkkkn

RRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLR
 .|||.| .|.  . |.   |...   ..|..|.  . . .. .    ||.. |.. |..| 
GkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP19_pd Subfamily DSP19 162-322 9.2e-17 55.8 In-house 7-150 (152) alignment 
Range on Protein: 162-322
Range on HMM: 7-150/152.0
YKDQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSnlsgeqvkrtirlKDCPCLCASTMKHTRIRLnlhLDETvGDGISHYFDEVNRFIEGARKSN
 .| .|.|. . ||.|  ..|. .  | . .| .|....              . |.. .. .. . | .   ||.     ...|..|.  ||| ||...
kedlevgeveprlylgsqdvaadkeilkekkitHilnva.............tgvpnvfpkdftylsiei...lDlp.etdllsylkealdFieearskd

RRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
 .||. |  |   ....   |...   ..|..|   . ...| ..  |||.. | ..|..|
gavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
0046846 (Phosphotyrosine protein) phosphatases II 162-323 3e-12 42.1 In-house 7-173 (176) alignment 
Range on Protein: 162-323
Range on HMM: 7-173/176.0
YKDQNVTEILDFLYMGDLE----------AANREPLLCRLNIEYIIDLSNLSGEQVKRtirlkdCPCLCASTMKHTRIRLNLHLDETVGDGIsHYFDEVN
. | ....|.. |..|..            |.   .| .|.|.....| ..   .  .      || ..   .|.    |.|. ..     .  ...|. 
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlk......cpnywpeleklgiqylhlpwpDhgvpdl.elllell

RFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQV-MGMTLKQAHGHITKIKP-EVTFREGFQRALIRLEQNLR
.||. |.|....||. |. |.  ..|.   |...  .|... .|  .. ...|  .   ... | | . |. |.
efirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_DSP6_pd Subfamily DSP6 164-323 2.8e-15 50.2 In-house 11-155 (158) alignment 
Range on Protein: 164-323
Range on HMM: 11-155/158.0
DQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgeQVKRTIRLkdcpclcASTMKHTRIRLNLHLDetvgDGISHYFDEVNRFIEGARKSNRR
..   |||..||.|  ..|.   .| .|.|.|.... .    ..  . .        .  .|...| .. ||       ....| |  .||. ||...  
aefpveilpllylGsakdasnlevlkklkikyvlnvts....nlpnkfee.......sgelkylqipiedhls....qnlakffPeaiefidearskksk

VLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLR
||..| .|.  . |.|  |... . ..|..|.  . | |....    |   |.  |..||
vlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
subfamily_DSP8_pd Subfamily DSP8 164-323 4.3e-15 49.6 In-house 12-155 (159) alignment 
Range on Protein: 164-323
Range on HMM: 12-155/159.0
DQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgeqvkrtiRLKDCPCLCASTmkHTRIRLNlhldETVGDGISHYFDEVNRFIEGARKSNRR
| ..|.||..||.|  . .  | || .|.|.|.. .||             .  .|. |     |. ..    ..  . .. .||.   ||. |...| |
dvgptrilknlylGsqkdvlseellsklgisyvlnasn..........scpkleelkesk..flrvPvk....Dkydekllpwfdksvefidkaksengr

VLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLR
||... .|   ..|.   |... . |.| .|. .. . .| .     |.  |.  |..|.
vlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_DSP3_pd Subfamily DSP3 164-325 5.8e-14 46.0 In-house 8-160 (162) alignment 
Range on Protein: 164-325
Range on HMM: 8-160/162.0
DQNVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEQVKRTIRL-KDCPclcastmkhtrIR-LNLHLDETVGDGISHYFDEVNRFIEGARKS-
 ..| |. . ||.|| ..|. .  | .| | .... .. .  .|.      ||             |. | |..|..    .|.||... .||. | .. 
skevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdle...........ikylGlevdDvpefdlskyFetaakfidealsqk

NRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKiKPEVTFREGFQRALIRLEQNLRPK
. .||. ||.|.  ..|.   |.. .  |||..|  .. | | |..  ||| . |. |...|. |
egkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrk.kReilPneGFlkqLaeldeelkrk
0036282 (Phosphotyrosine protein) phosphatases II 165-320 5.6e-09 31.4 In-house 10-167 (174) alignment 
Range on Protein: 165-320
Range on HMM: 10-167/174.0
QNVTEILDFLYMGDLEAAnREPLLCRLNIEYIIDLSNLSGEQVKRTIRLKDCpcLCASTMKHTRIRLNLHLDETVGDGISHyFDEVNRFIEGARKS--NR
 ....|.. |. |.  .|   ..|..|.|.....| ..   .  . |..     |  .  ..    | |. .      .|  ..|. .|.| |...  ..
ldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpe..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpgg

RVLIYCVTGLILAPTITTQYMIQVMGM-TLKQAHGHITKIK---PEVTFREGFQRALIRLEQ
 ||. |  |.  ..|.   |.. .... .| .|  .. ...   | .  .... | |  .|.
pvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
subfamily_DSP14_pd Subfamily DSP14 166-327 2.6e-19 63.7 In-house 6-149 (157) alignment 
Range on Protein: 166-327
Range on HMM: 6-149/157.0
NVTEILDFLYMGdLEAANREPLLCRLNIEYIIDLSNlsgEQVKrtIRLKDCPclcastmkhtriRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVL
....| . |...   ||... || . .|  ||...    |...   .|||              |... ....    ....||||   || ..|.. ..|
alsqitpsLfls.gvaalskellkkkkitliinvtv...elpn..tklkdie............rvkvpveDnpeaklakhfdevadkieevkkkggktl

IYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLRPKAA
..||.|     .... |...   ..|..|. .. ...| .    || . ||..|..|. |..
vhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkss
0048076 (Phosphotyrosine protein) phosphatases II 166-322 2.7e-16 55.0 In-house 3-142 (145) alignment 
Range on Protein: 166-322
Range on HMM: 3-142/145.0
NVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLsnlsgeqvkrtirlkdcPCLCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVL
...|||. || |.| .|.. .||..|.| ....|                  . .    ..    |.| ..      .. ...|. .||| |.|....||
wpseilpglylgslptaldlellkdlgittvlnl.................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvl

IYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
..|  |.  ..|.   |..  .|..| .|  .. .  | .  ..|..| |...|. |
VHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 166-320 3.8e-15 51.4 In-house 3-142 (144) alignment 
Range on Protein: 166-320
Range on HMM: 3-142/144.0
NVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlSGEQVKRTIRlkdcpclcastmkhTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVL
|..|||. ||.|.| .|.. .||..|.| ..|.|.. . |.   .                    |.| ..      ......|. .||| |......||
npseilpglylgslptaldlellkklgittvinlte.eyepeflere..............giqylhlpwpDhgvpdllellleflefieealeeggpvl

IYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
..|  |.  ..|. . |.. ..|..|..|  .. .. | .   .|. | |...|.
VHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0051082 (Phosphotyrosine protein) phosphatases II 166-305 7.2e-10 34.2 In-house 7-136 (151) alignment 
Range on Protein: 166-305
Range on HMM: 7-136/151.0
NVTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEQvkrtirlkDCPCLCAS-TmkhtRIRLNLHLDETVGDGISHYFDEVNRFIEGARKS-NRR
| . . ..|| ..   |   .|| .|.| .|..| ..   .         ||... .      .  |..... .   |....||.|..|.| ...  |  
nfsyvtgglyrsggpladflellkelgiktivnlrseeerg........ycpeylpelg....ievlhipildwpdpglplsfdavleflellldkkngp

VLIYCVTGLILAPTITTQYMIQvMGMTLKQAHGHITKIKP-EV
||..|  |.    |.   |..  .|..| .|  .. .. |  |
vlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvv
subfamily_Slingshot_pd Subfamily Slingshot 166-319 8.6e-10 32.3 In-house 18-154 (169) alignment 
Range on Protein: 166-319
Range on HMM: 18-154/169.0
NVTEILDFLYMGD-LEAANREPLlCRLNIEYIIDLSnlsgeqvkrtirlKDCPCLCASTMKHTRIRLNlhlDETVgDGISHYFDEVNRFIEGARKSNRRV
. ..| |..|.|   .|.| | |  . ..|||....             |..    . ......||.    ||   . . .|..|  .||| |.|.. .|
saskifdhvylGsewnasnleel.kengveyilnvt.............keidnffpekfeylnirvy...deee.tdllkywnetykfiekakkkgskv

LIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLE
|..|  |.  . ..   | ..  |..|..|. .. . .  .   .|| . |   |
lvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeye
PTPc_motif_SM00404 167-320 4.8e-21 70.1 In-house 2-139 (140) alignment 
Range on Protein: 167-320
Range on HMM: 2-139/140.0
VTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEQvkrtirlkdcpclcasTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLI
...||. ||.| ...|....||  |.|...|....    .                  .  . .|.. ||..  | .|.|.|.|..||| |.|....||.
psrilphlylgskskaqnpallkklgithvinvteevslt................kensgfqilqiplddnekdklskyldkvldfienaekkggkvlV

YCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
.|  |.    |... |... ....|..|   . . .| .  ...| | || .|.
HCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP12_pd Subfamily DSP12 167-315 3.2e-16 54.1 In-house 2-136 (155) alignment 
Range on Protein: 167-315
Range on HMM: 2-136/155.0
VTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgEQVkrtirlkdcPCLC--ASTMKhtriRLNLHL-DETVGDgISHYFDEVNRFIEGARKSNRR
|..||. ||.|.|||...|.||  |.|. .. . .   |..         |     .....    ...... ||   | | ...||...||| |.. .. 
vsrilpglylggleavqeeellkelkithvlsvik...eel.........pehklkkgkvs....tkfiqilDepeed.iLshldeavdFieealeeega

VLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRAL
||. |  |.    || . |...  .. |..|.  . ..|||..  |||.. |
vlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQL
subfamily_DSP15_pd Subfamily DSP15 167-319 2.7e-14 47.5 In-house 2-136 (151) alignment 
Range on Protein: 167-319
Range on HMM: 2-136/151.0
VTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNlsgeqvkrtirlkdcpclCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLI
....|  ||.|... .. | || . ||  |. ...                   |  . .    . .....| .  .|..|.| ..||  .|  .  ||.
iskvlpglylgnfrdskdeelLkeknithilsvhd..................nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlv

YCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLE
.|. |.  . |... |.. |. .  ..|   | . .       ||.| |   |
hClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeye
0043147 (Phosphotyrosine protein) phosphatases II 167-322 1.6e-11 39.7 In-house 19-160 (172) alignment 
Range on Protein: 167-322
Range on HMM: 19-160/172.0
VTEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLsgeqvkrtirlkdcPCLCASTMKHTRIRLNLHLDETVGDgISHYFDEVNRFIEG--ARKSNRRV
 ...........   |    .| .|.| .|..| .|               ...   ...    | |  .      .. ...|. .||.   |.... .|
pdrfiatqgplrntladfwrmlkelgithivnltel..............lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpv

LIYCVTGLILAPTITTQYMIQvMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
|. |. |.  ..|.   |... .|..| .|  .. . .| .   ....| |  .|. |
lVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0042113 (Phosphotyrosine protein) phosphatases II 167-321 4.2e-07 25.1 In-house 47-241 (245) alignment 
Range on Protein: 167-321
Range on HMM: 47-241/245.0
VTEILDFLYMGDLEAANREP----LLCRLNIEYIIDLSNLSGEQV--------------------------------KRTIRLKDCPCLCastmkhTRIR
. .| . .....  ...  .    .| .|.|..|..|...   .                                  ||..... .. .      .|  
gyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgdde......srev

LNLHLDETVGDG---ISHYFDEVNRFIEGARK--SNRRVLIYCVTGLILAPTITTQYMI-----QVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
...|     ..|   .. ..... .|.. |..  || .||. |  |.  . |. . |..       .|..| .|  .. . .| .   ... | |.....
ihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

N
.
e
subfamily_LRR-DSP_pd Subfamily LRR-DSP 168-322 1.5e-14 47.7 In-house 121-258 (263) alignment 
Range on Protein: 168-322
Range on HMM: 121-258/263.0
TEILDFLYMGDLEAANREPLLCRLNIEYIIdlsnlsgeqvkrtIRLKDCPCLCASTMKHTRIRlnlHLDETVGDGISHYFDEVNRFIEGARKSNrRVLIY
 ||.| |..| |..|| ...|  |.. .|.             . . |.  |   ..|.  |    .....    || .|.|.| |||  ||.   ||..
deiidklflGgldsannksilkdlgvthil.............lavadfePlfPklfkylsid...diedvdeadisqhfeetnafieeGrkkG.Gvlvh

CVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
| .|.  . |..  |...   ...|.|   . | .|..    ||.  | . |..|
craGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
0049260 (Phosphotyrosine protein) phosphatases II 168-320 4.4e-09 31.7 In-house 9-147 (152) alignment 
Range on Protein: 168-320
Range on HMM: 9-147/152.0
TEILDFLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEQVKRTIRLKdcpclcastmkhtrIRLNLHLDETVGDGISHYFDEVNRFIEG-ARKSNRRVLI
.|.. ....|.  .|.   .| .|.| .|. | .|.      . ..                 |.|  .      .| .......|||  |.... .||.
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlV

YCVTGLILAPTITTQYMIQvMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
 |. |.  ..|.   |..  .|..|..|  .. . .| .   .|. | |   |.
HCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
0040439 (Phosphotyrosine protein) phosphatases II 169-321 6e-09 31.4 In-house 31-244 (249) alignment 
Range on Protein: 169-321
Range on HMM: 31-244/249.0
EILDFLYMGDLEAANREPL------------------------LCRLNIEYIIDLSNLSGE--------------------------------QVKRTIR
.||. |. .|   |.  ..                        | .|.|..|..|..|                                    . ||..
silpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtle

LKDCpclcasTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARK------SNRRVLIYCVTGLILAPTITTQYMI-----QVMGMTLKQAHGHITKI
|..         . .|  | ..      .|.. .|... .||| .||      .. .||. |  |.  ..|. . |..        |..|..|  .. . 
ltnl......ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsq

KPEVTFREGFQRALIRLEQN
.| .   ... | |..... 
Rpgavqnpeqyrflyealle
subfamily_STYXL1_pd Subfamily STYXL1 172-322 3.4e-09 30.1 In-house 17-153 (157) alignment 
Range on Protein: 172-322
Range on HMM: 17-153/157.0
DFLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEqvkrtirlkdcpclCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTG
..||.|. . |  . .   | .   ...|. ...                ......   |.......    . . ..|. .|||  .|... ||..   |
gklylGnykqaqnpaikkdlkvkahvnvsmdadk..............liagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkG

LILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
.  . ..   |..    .|||.|. .. | |. |  . .|   | . |..|
isrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 173-321 5.6e-11 36.2 In-house 14-146 (148) alignment 
Range on Protein: 173-321
Range on HMM: 14-146/148.0
FLYMGDLEAANREPLLCRLNIEYIIDLSNLSGEQVKRTirlkdcpclcastmkhtRI-RLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTG
||..|. . |     |  |..  |.. ..     .                     |  |.. ||.     .| .|...  |.. |..  ||||. .  |
fLFlGskksaadlealkalgvtrivnatkerdnaldqr.................gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmG

LILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQN
   .  ..  ..|.   ..||.|   .   .. |  . || . |  |||.
vsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqa
DSPc Dual specificity phosphatase, catalytic domain 174-320 8.4e-17 56.3 Pfam-A 1-132 (133) alignment 
Range on Protein: 174-320
Range on HMM: 1-132/133.0
LYMGDLEAANrEPLLCRLNIEYIIDLSNLSGEQvkrtirlkdcpclcASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTGLI
||.|  ..|. ..||  |.|...|....   ..               .  |  . .|.. ....  . || ...|. .||| |......||..|  |. 
lylgskstas.lalleklgitlvinvtkevpnn..............naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGis

LAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
  .|... |... ....|..|  .. . .. .  ..||.| |. .|.
RSatliiaYlmktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 174-320 8.4e-17 56.3 In-house 1-132 (133) alignment 
Range on Protein: 174-320
Range on HMM: 1-132/133.0
LYMGDLEAANrEPLLCRLNIEYIIDLSNLSGEQvkrtirlkdcpclcASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTGLI
||.|  ..|. ..||  |.|...|....   ..               .  |  . .|.. ....  . || ...|. .||| |......||..|  |. 
lylgskstas.lalleklgitlvinvtkevpnn..............naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGis

LAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
  .|... |... ....|..|  .. . .. .  ..||.| |. .|.
RSatliiaYlmktknlslneAyefvkerrskispnagflrqLleyer
0045450 (Phosphotyrosine protein) phosphatases II 187-321 1.3e-08 30.5 In-house 126-302 (307) alignment 
Range on Protein: 187-321
Range on HMM: 126-302/307.0
LLCRLNIEYIIDLSNLSGE---------------------------------QVKRTIRLKDCpclcaSTMKHTRIRLNLHLDETVGDGISHYFDEVNRF
.| ......|..|..|                                     . ||....|.     .  . .|.   .|  .  ..|.. .|.|. .|
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.....dgtgesrtvthfhytgwpdhgvppsfeelldf

IEGARK------SNRRVLIYCVTGLILAPTITTQYMIQVMG--------MTLKQAHGHITKIKPEVTFREGFQRALIRLEQN
|| .||      .. .||. |  |.  ..|. . |.. ...        ..| .|  .. . .| .   ... | |..... 
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0038934 (Phosphotyrosine protein) phosphatases II 190-329 1e-09 33.8 In-house 40-183 (194) alignment 
Range on Protein: 190-329
Range on HMM: 40-183/194.0
RLNIEYIIDLSNLSGEQVKRTIRLK------DCPCLCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIegARKSNRRVLIYCVTGLILAPTITTQYM
|...| .... .| ....   |.|       |.  . .. ... ..    .      . . ...| |..|.  .....  |.. |. ||  ..|.   |.
rfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYL

IQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLRPKAALP
|...||....| .... ..| .  . .. .|| .  ..||...  |
iyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlap
0040438 (Phosphotyrosine protein) phosphatases II 190-322 7.6e-06 20.9 In-house 108-275 (317) alignment 
Range on Protein: 190-322
Range on HMM: 108-275/317.0
RLNIEYIIDLSNLSGEQ--------------------------------VKRTIRLKDCPCLcastmkHTRIRLNLHLDETVGDGISHYFDEVNRFIEGA
......|. | .|   .                                . ||....|  .        .|.   .|      .|.  ..|.. .|.| .
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgds......esrtvthfhytgWpdhgvppspdllldfleav

RKS----NRRVLIYCVTGLILAPTITTQYMI-----QVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
|..    .  ||. |. |.  . |. . |..     . .|.....|  .. . .| .   ... | |.......
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
0049772 (Phosphotyrosine protein) phosphatases II 197-322 1.6e-10 36.7 In-house 161-273 (314) alignment 
Range on Protein: 197-322
Range on HMM: 161-273/314.0
IDLSNLSgeqvkrtirlkD-C--PCLCAST-MKHTRIrlnlHLDETVGDgISHYFDEVNRFIEGArKSNRRVLIYCVTGLILAPT-ITTQYMIQVMGMTL
 || .|            . .  | |.  . .|. ||    ...    . .. .|||. .||| | . ...||. |  |   ..| ... |..  .|..|
adlellk...........eelydpelferlgikylri....pvpDgsap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsl

KQAHGHITKIKPeVTFREGFQRALIRLEQNL
..|  .. .. | .  ..|| . |...|. |
eealedvrlkRp.inpnpgfieqleqyefil
subfamily_STYX_pd Subfamily STYX 219-319 5e-07 23.0 In-house 54-154 (166) alignment 
Range on Protein: 219-319
Range on HMM: 54-154/166.0
LCASTMKHTRIRLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRL
|    ....   | | . ... . |  |. .|  ||... ..  .||..  .|.  . ..   |... .|.  ..|. .. . .  ..  ||| . |   
likpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkey

E
|
e
subfamily_MKPLT_pd Subfamily MKPLT 230-320 1.1e-10 35.3 In-house 68-158 (164) alignment 
Range on Protein: 230-320
Range on HMM: 68-158/164.0
RLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
 |........ . .| ... .. |.  | .|  |||..|| |   . ..| ...|.  | |||.|. .. . .  |.   || . | . |.
YlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 230-320 1.1e-10 35.3 In-house 68-158 (164) alignment 
Range on Protein: 230-320
Range on HMM: 68-158/164.0
RLNLHLDETVGDGISHYFDEVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQ
 |........ . .| ... .. |.  | .|  |||..|| |   . ..| ...|.  | |||.|. .. . .  |.   || . | . |.
YlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 241-323 3e-08 26.9 In-house 60-142 (145) alignment 
Range on Protein: 241-323
Range on HMM: 60-142/145.0
DGISHYFDEVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNLR
  .| .||||  ||.  ..    |...|..|.  . |..  ....  .||| .|   .   .        | ..|..||..|.
ydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlk
0048567 (Phosphotyrosine protein) phosphatases II 243-305 2.2e-06 22.2 In-house 56-121 (157) alignment 
Range on Protein: 243-305
Range on HMM: 56-121/157.0
ISHYFDEVNRFIEGARKSNRRVLIYCVTGL---ILAPTITTQYMIQVMGMTLKQAHGHITKIKPEV
. ...  .|.|..  .. .... ..| .||     . |.   |.| ..|.|  .| ...  . |  
lyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgs
subfamily_PTPMT1_pd Subfamily PTPMT1 249-322 4.3e-07 24.5 In-house 95-168 (171) alignment 
Range on Protein: 249-322
Range on HMM: 95-168/171.0
EVNRFIEGARKSNRRVLIYCVTGLILAPTITTQYMIQVMGMTLKQAHGHITKIKPEVTFREGFQRALIRLEQNL
.  .|||  ... .|| . | .|   . |. . |...   .....|. .. |... .  ..  ..|| . |..|
kgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl