Gene DSP11 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP11
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP010_AA protein Get Run
SpurP010_AA_62-206 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_RNGTT_pd Subfamily RNGTT 63-212 1.1e-36 120.3 In-house 35-183 (189) alignment 
Range on Protein: 63-212
Range on HMM: 35-183/189.0
IPDRFTPDDLLQKLNEMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKVFTPGHVV-PPPEVVDKFTAAVSSFKEynKDNDMIIGVHCTHGVNRTGYLVC
.  ||.|. ||. |. .....||.|||| |.|||. | . .....|||. . |. . | .| |..|   |..| .  |  . .|||||||| ||||.|..
eenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffk..knpeevigvhCthGfnRtGFliv

RYLIEREGYKPKDALKAFEEARGYPIERENYIEDLLQLSGDRRESVRSKEF
 ||.|.| .. ..|...| .||   | .|.|...||.  .| .|.. . | 
syLvekedwsveaavalFakaRppGiykedylkellrrYadveeaiaapel
0046846 (Phosphotyrosine protein) phosphatases II 63-195 1.1e-17 59.9 In-house 30-164 (176) alignment 
Range on Protein: 63-195
Range on HMM: 30-164/176.0
IPDRFTPDDLLQKLNEMnyRMGLIIDLTATT-------RYYNPEiFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFKEYNkdndMIIGVHCTHGVNR
 | . |  | |. | |.  . .....||  .        .| || . . ..||  . .| | ||. | .... ... .. . .      . ||| .|..|
gplprtladflemlkel..gitavvnlteevelgrlkcpnywpe.leklgiqylhlpwpDhgvpdlelllellefirealkeg....gpvlVHCsaGigR

TGYLVCRYLIER-EGYKPKDALKAFEEARG-YPIERENYIED
|| ||. ||.|.  |... .||. . | |  . .. ..... 
tgtlvaayllelekglsveealalvreqRplgavqtpeQyrf
subfamily_DSP11_pd Subfamily DSP11 64-203 2.1e-68 223.7 In-house 38-177 (178) alignment 
Range on Protein: 64-203
Range on HMM: 38-177/178.0
PDRFTPDDLLQKLNEMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFKEYNKDNDMIIGVHCTHGVNRTGYLVCRY
 .||||.|||.||.|.|...||.||||.|.|||... ..|..|.|.|...|||.||  |.|.||..||..|.|.|||||..|||||||||||||||.|||
ekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCry

LIEREGYKPKDALKAFEEARGYPIERENYIEDLLQLSGDR
||..|||.|.||..|||||||...|||||..|| .|. |.
lidvegyepedaieafeearGhslerenylkdLkklekdk
0038934 (Phosphotyrosine protein) phosphatases II 64-218 4.6e-42 139.2 In-house 38-191 (194) alignment 
Range on Protein: 64-218
Range on HMM: 38-191/194.0
PDRFTPDDLLQKLNEMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKVFTPGH-VVPPPEVVDKFTAAVSSFKeyNKDNDMIIGVHCTHGVNRTGYLVCR
  ||.|.||.. |...|...||.|||| |.|||.|| | .....|.| ..|.. .||. |....|  .|  |   |.|.. ...|||..|..|||.||..
lyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaa

YLIEREGYKPKDALKAFEEARGYPIERENYIEDLLQLSGDRRESVRSKEFHDVYFQ
|||.| |.....|.. |.|.|.  |.. .|.|.||.  .. |..|...| ......
YLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapekpellle
0043147 (Phosphotyrosine protein) phosphatases II 64-199 2.2e-23 78.3 In-house 28-156 (172) alignment 
Range on Protein: 64-199
Range on HMM: 28-156/172.0
PDRFTPDDLLQKLNEMNYRMglIIDLTatTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFKeyNKDNDMIIGVHCTHGVNRTGYLVCRY
| |.| .| .. | |.. ..  |..||  ...|.|| . . ..||  .  | | ||..|....|   . ..   .....  . |||..||.|||.||. |
plrntladfwrmlkelgith..ivnlt..ellydpellerlgiqylylpwpDhgvpllellleflefidell..alspggpvlVHCsaGvgRtgtlvaay

LIErEGYKPKDALKAFEEARGYPIERENYIEDLLQL
|.. .|... .|.. . |.|.. .. ....  |...
lml.lglsleeavalvrekRpgavqnpsqyrflyyf
0041856 (Phosphotyrosine protein) phosphatases II 68-193 2.5e-22 74.8 In-house 46-160 (182) alignment 
Range on Protein: 68-193
Range on HMM: 46-160/182.0
TPDDLLQKLNEMnyRMGLIIDLTatTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSfkeynkdNDMIIGVHCTHGVNRTGYLVCRYLIER
|. | |. | |.  . ..|..||   ..|.|| . .  .||.... |.| ||... . .|  .| .       ..  . |||..||.|||.||. ||...
tvadflrmlkel..gittivnlt..eelywpellerlgiqylylpwpDhgvpdldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkk

EGYKPKDALKAFEEARGYPIERENYI
 |. . .|.| . ..|   ....|..
lgvsleeavklvrsrRpgmvitpnqy
0049772 (Phosphotyrosine protein) phosphatases II 68-200 4e-22 74.8 In-house 155-270 (314) alignment 
Range on Protein: 68-200
Range on HMM: 155-270/314.0
TpdDLLQKLNEMNYRmgliidltatTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFkeynkDNDMIIGVHCTHGVNRTG-YLVCRYLIE
.  ...   .  ...          ...|.|| | .. ..|. . .|.. .|..| .|.| ... ..     |..  . |||..|..||| ..|. ||. 
g..neptaadlellk..........eelydpelferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmk

REGYKPKDALKAFEEARGyPIERENYIEDLLQLS
. |. ...||. . ..|     ....|| |.|. 
llgvsleealedvrlkRp.inpnpgfieqleqye
0040439 (Phosphotyrosine protein) phosphatases II 68-198 7.7e-19 63.7 In-house 66-240 (249) alignment 
Range on Protein: 68-198
Range on HMM: 66-240/249.0
TPDDLLQKLNEMNyrMGLIIDLTATTRY-------------------------------------------YNPEIFIDRDVQYVKVFtPGHVVPPPEVV
| .| .. | | .   . |..|| ....                                           |..| .  . .||..     .| | .| .
tvedfwrmlwelg..itvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedl

DKFTAAVSSFKEYNkDNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERENYIEDLLQ
..|  || .. |.. ...  . |||..||.|||.... ||.     .. |. ...|.| . ..|.. .. ..... |..
ldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflye
0042113 (Phosphotyrosine protein) phosphatases II 68-197 3.3e-18 61.4 In-house 64-236 (245) alignment 
Range on Protein: 68-197
Range on HMM: 64-236/245.0
TPDDLLQKLNEMNyrMGLIIDLTATTRYYN-----------------------------------------PEIFIDRDVQYVKVFTPGHVVPP-PEVVD
|..| .. | | .     |..|| .. .                                           .. .   ...|  .  |.| ||. .| ..
tvedfwrmlwelg..ittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllelll

KFTAAVSSFKEYnkDNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERENYIEDLL
.|  .| .. .   |..  . |||..||.|||.... ||.     .. |. . .|.| . . |.  .. ..... | 
dflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 68-209 2.4e-11 39.3 In-house 34-269 (272) alignment 
Range on Protein: 68-209
Range on HMM: 34-269/272.0
TPDDLLQKlneMNYRMGLIIDLTATT-RYYNPEIFIDRDVQYVKVFTPGHVVPPPE--------------------------------------------
|..|. .     ...   |.||. .. | ...  .   ...|. . ......|...                                            
taadfwrl...kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdw

--------VVDKFTAAVSSfkeynkdnDMIIGVHCTHGVNRTGYLVCRYLIErEGYK--------------PKDALKAFEEARGYPIE------------
         . .. ... .        .  . |||..|..||| .|. .|.  .|                . .|..   ..| . ..            
pdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal

----------------------------RENYIEDlLQLSGDRRESVRS
                             |.|..| |.|| . .| .|.
lellrsllsvraeyllaaldaideeyGsvegYLrd.lglseeelerLre
subfamily_CDC14_pd Subfamily CDC14 68-169 6.1e-07 23.6 In-house 200-290 (328) alignment 
Range on Protein: 68-169
Range on HMM: 200-290/328.0
TPDDLLQKLNEMNyrMGLIIDLTATtrYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFkeynkdnDMIIGVHCTHGVNRTGYLVCRYLIER
.|. ||.  .. |  .  .. | .    |. . | |  .... .|     .|. ..| ||.... .        .  | |||  |. ||| |.  ||...
aPeklleyfrknn..vttvvrLnkk..lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.......eGaiavhCkaGLGrtGtLiacylmkh

EG
 .
yr
0036282 (Phosphotyrosine protein) phosphatases II 71-199 2e-23 78.4 In-house 39-165 (174) alignment 
Range on Protein: 71-199
Range on HMM: 39-165/174.0
DLLQKLNEMNYRMGLIIDLTATTRYYnpeiFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFKEYnkDNDMIIGVHCTHGVNRTGYLVCRYLIEREGY
.... |.|.   ....|... ..|..    . . ..||... .|.| ||. .....|  .| .. .   |..  . |||..||.|||.||. ||..| ..
tvvmlleekelglykcinywpelred....lerlgiqylylpwpDhgvpdlsillefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll

-KPKDALKAFEEAR---GYPIERENYIEDLLQL
 .. |||. . |.|   .. ........ | ..
eslvdaldlvrelRlqrpgmvqtpsQyrflyyf
subfamily_PTEN_pd Subfamily PTEN 71-183 1.2e-10 36.6 In-house 49-156 (184) alignment 
Range on Protein: 71-183
Range on HMM: 49-156/184.0
DLLQKLNEMNYRMGLIIDLTAtTRYYNPEIFiDRDVQYVKVftPGHVVPPPEVVDKFTAAVSSFKEynKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGY
|. . |..       |..|..  |.|. . | |  |. ...    |  || |.....   .... |  .|.. .. |||  |  ||| |.. ||...  .
dvvkflekkhkdhykiynlrs.erkydskkf.dgrvavypf..dDhnppplelleeivediekwle..edkknvvvvHCkaGkGRtGvlivayllkslll

KPK-DALKAFEEAR
. . .||. |.|||
ekaeealelfaeaR
PTEN_1 73-185 3.1e-19 64.6 In-house 56-173 (196) alignment 
Range on Protein: 73-185
Range on HMM: 56-173/196.0
LQKLNEMNYRMG--LIIDLTATT----RYYNPEIFIDRDVQYVKVFTPGHVVPPPEvvdKFTAAVSSFKEYNKD--NDMIIGVHCTHGVNRTGYLVCRYL
.... .... .|  |...|.       | |..|.|....|.| ..  . | .|. .   .. ... ||.|. .   |  .. |||..|..|.| .|. ||
vaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapsls...elfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayL

IEREGYKPKDALKAFEEARGY
...... ...||. . |.|  
mykgkltadeAlelvrekRpp
0051082 (Phosphotyrosine protein) phosphatases II 73-190 8.8e-17 56.6 In-house 26-139 (151) alignment 
Range on Protein: 73-190
Range on HMM: 26-139/151.0
LQKLneMNYRMGLIIDLTATT-RYYNPEIFIDRDVQYVKVFTPGHVVPPpeVVDKFTAAVSSFKEYNKDNDMIIGVHCTHGVNRTGYLVCRYLIErEGYK
|. |   ..    |..|. .. |.|.||.. . ..... .  ... .|.  . . | |... .........  . |||..|..||| ||. ||.  .|. 
lell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpg..lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvs

PKDALKAFEEARGYPIERE
. .||. . . |.. .  .
leealeeyrlkrpgvvqpn
0045098 (Phosphotyrosine protein) phosphatases II 76-187 8.2e-15 50.4 In-house 126-255 (278) alignment 
Range on Protein: 76-187
Range on HMM: 126-255/278.0
LNEMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKV-FTPGHVVPPPEVVDKFTAAVSSFKEYNK-------------DNDMIIGVHCTHGVNRTGYLVC
|.|... .  ...|. |  ....| .  | |....  . | | ||. .... |  ..   .|..|             |..  . ||| .||.||| ||.
lseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlva

RYLIERE---GYKPKDALKAFEEARGY-PI
 ||. .    |. . .|.| . . |..  .
aylmlelleggvdlleavkelrsqRpglav
0046845 (Phosphotyrosine protein) phosphatases II 77-191 1.5e-11 39.7 In-house 141-261 (284) alignment 
Range on Protein: 77-191
Range on HMM: 141-261/284.0
NEMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKVFtpGHVVPP-PEVVDKFTAAVSSFKEYnKDNDMIIGVHCTHGVNRTGYLVCRYLIERE-------
.|...    .. |. |   |. | .. .  .| .     | ||| || . .|  .| .. |   ...  | ||| .||.|||.... .|. .        
seevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekegll

-GYKPKDALKAFEEARGYPIEREN
 |. . .|.| . | | . .. . 
lgvdvleavkrlreqRpgmvqtle
0049260 (Phosphotyrosine protein) phosphatases II 78-199 1.3e-21 72.3 In-house 27-145 (152) alignment 
Range on Protein: 78-199
Range on HMM: 27-145/152.0
EMNYRMGLIIDLTATTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSFKeyNKDNDMIIGVHCTHGVNRTGYLVCRYLIErEGYKPKDALK
.| ...|  . .. |......... ..  ||  ...| | ||. . . .|   .  .   ..|..  . |||..||.||| ||. ||..  |.....|..
rmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeava

AFEEARGYPIERENYIEDLLQL
 . |.| . .. ..... |.. 
lvrekRpgavpnpgqlrflyef
0048179 (Phosphotyrosine protein) phosphatases II 79-199 2e-20 68.4 In-house 26-140 (144) alignment 
Range on Protein: 79-199
Range on HMM: 26-140/144.0
MNYRMGLIIDLTATtryYNPEIFIDRDVQYVKVFTPGHVVPPP-EVVDKFTAAVSSFKEynkdNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALK
 ..  ...|.|| .   | || ...  .||... .|.| ||.  | ...| ... .. |    ..  . |||..||.|||.||. ||. ..|. ...||.
kklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

AFEEARGYPIERENYIEDLLQL
 . ..| . .. ..... ||..
lvrsrrpgavpnpgqlrfLley
0048076 (Phosphotyrosine protein) phosphatases II 79-198 7.1e-20 66.6 In-house 26-137 (145) alignment 
Range on Protein: 79-198
Range on HMM: 26-137/145.0
MNYRMGLIIDLtattrYYNPEIFIDRDVQYVKVFTPGHVVPPP-EVVDKFTAAVSSFKEynkdNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALK
 ..  .....|      ...| . . ..||. . .|.| ||.  | ...| ... .. .    ..  . |||..||.|||.||. ||. ..|. . .||.
kdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealk....eggpvlVHCsaGvgRtgtlvaaylmlllgvsleeale

AFEEARGYPIERENYIEDLLQ
 . ..| . ........ |..
lvrsqrpgavpnpgqlrflye
0037934 (Phosphotyrosine protein) phosphatases II 80-198 3.7e-19 64.7 In-house 70-236 (243) alignment 
Range on Protein: 80-198
Range on HMM: 70-236/243.0
NYRMGLIIDLTATT----------------------------------------RYYNPEIFIDRDVQYVKVFTPGHVVPP-PEVVDKFTAAVSSFKEY-
... . |..|| ..                                        ...... .   ...|  .  |.| ||. || . .|  .| .| |  
elgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieel

----NKDNDMIIGVHCTHGVNRTGYLVCRYLIERE-GYKPKDALKAFEEARGY-PIERENYIEDLLQ
    . |..  . |||..||.|||.|.. ||. .  |. . .|.| . | |..  .. ..... | .
lsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflye
0040438 (Phosphotyrosine protein) phosphatases II 80-198 3.3e-17 58.2 In-house 108-270 (317) alignment 
Range on Protein: 80-198
Range on HMM: 108-270/317.0
NYRMGLIIDLTATTRY----------------------YNPEIFIDRDVQYVKVFT-------------------PGHVVPP-PEVVDKFTAAVSSFKEy
... ..|. || .. .                       . ... . .... ..                     | | ||| |. . .|  || .. | 
eqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.

nkDNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERENYIEDLLQ
  |..  . |||..||.|||.... ||.     ...|. ...|.| . |.|.. .. ..... | .
..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd
0044763 (Phosphotyrosine protein) phosphatases II 81-198 7.5e-22 73.3 In-house 47-165 (178) alignment 
Range on Protein: 81-198
Range on HMM: 47-165/178.0
YRMGLIIDLTATTRYY----NPEIFIDRDVQYVKVFTPGHVVPP-PEVVDKFTAAVSSFKEynkDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDA
.  ..|..|| .....    .|. . . ..||... .|.| ||. .| ...|.... .. .   ...  . |||..||.|.|.||. ||. . |. . .|
lgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkklglsleea

LKAFEEARGyPIERENYIEDLLQ
.. . |.|   ........ |..
ielvrerRp.ivpnpgqlrqLye
0043336 (Phosphotyrosine protein) phosphatases II 81-195 1.7e-15 52.7 In-house 154-268 (278) alignment 
Range on Protein: 81-195
Range on HMM: 154-268/278.0
YRMGLIIDLTATTRyYNPEIFIDRDVQYVKVFtpGHVVP-PPEVVDKFTAAVSSFKEynkDNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKD
.    ...|. | . ...| .. . ..|...    | || ... . .|  || .. |   |..  . |||..||.|||.... ||.      . |. . .
lddytvrtlevtnl.gdgesrtvthyhylgwp..dhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdlee

ALKAFEEARGYPIERENYIED
|.| . | |.  .. ..... 
avkelreqRpgavqtpsqyrf
subfamily_DSP10_pd Subfamily DSP10 81-194 1.4e-06 22.3 In-house 38-144 (159) alignment 
Range on Protein: 81-194
Range on HMM: 38-144/159.0
YRMGLIIDLTATTryynPEIFIDRDVQYVKVftPGHVVPPPEVVDKFTAAVSSFKEYNKDNDMIIgVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFE
...  ....|...    |  | . ...| ..  | .     ..  .|..|.   .| .| .  .. |||  |. |   .|  ||... . . .|| |  .
lnitavlnvttsv....PnefeeealkYkri..pvsDtskqnlkqyfeealefieearkkgsrvL.vhCqaGisrsatvviaYlmkhlnlslndaykfvk

EARGYPIERENYIE
|.|       |.. 
ekrpiisPnLnfmG
0045450 (Phosphotyrosine protein) phosphatases II 82-198 1e-15 53.7 In-house 131-298 (307) alignment 
Range on Protein: 82-198
Range on HMM: 131-298/307.0
RMGLIIDLTATTRY---------------------------------------------YNPEIFIDRDVQYvkVFTPGHVVPP-PEVVDKFTAAVSSFK
. ..|..|| .. .                                             .. | .. .  .|     |.| ||| .| . .|  .| .. 
gvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy..tgwpdhgvppsfeelldfieevrkal

EYNkDNDMIIGVHCTHGVNRTGYLVCRYLIEREG--------YKPKDALKAFEEARGYPIERENYIEDLLQ
| . ...  . |||..||.|||.... ||. | .        . . .|.| . | |.  .. ..... | .
eel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye
0039614 (Phosphotyrosine protein) phosphatases II 82-196 1.2e-14 50.0 In-house 125-281 (297) alignment 
Range on Protein: 82-196
Range on HMM: 125-281/297.0
RMGLIIDLTATTRY--------------------YNPEIFIDRDVQ-----------------YVKVFTPGHVVPP-PEVVDKFTAAVSSFKEYNkDNDM
.   |. || .. .                    .. ... . ..                  .  .  | | ||| .|....|  .| .. ... ... 
gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael.pkgg

IIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERENYIEDL
 . |||..||.|||.... ||.     .. |. ...|.| . |.|.. .. ..... |
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl
0048567 (Phosphotyrosine protein) phosphatases II 89-183 8.3e-13 43.0 In-house 21-118 (157) alignment 
Range on Protein: 89-183
Range on HMM: 21-118/157.0
LTATTRYYNPEIF-IDRDVQYVKVFTPGHvVPPPEVVDKFTAAVSSFKEYNKDNDMIIGVHCTHGV---NRTGYLVCRYLIEREGYKPKDALKAFEEAR
  .....||. .| ||....|.  | .    ..  .. .|   . .| .. . ..  | |||..|     ||..|.. ||| . |. | .|.. .  .|
prlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
subfamily_DSP23_pd Subfamily DSP23 89-188 2.3e-08 28.8 In-house 35-130 (148) alignment 
Range on Protein: 89-188
Range on HMM: 35-130/148.0
LTATTRYYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVssfKEYNKDNDmIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIE
| . |   .|..    .. .|..  . .  | .| |..|   |   .| .. |.  ..|||  |  ||| ..  ||.  ..    .|.    . |   .|
lvslteegrphveatpnltlvrlriddyhppaleqvvefvrvv...eeaeekne.avsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsve
subfamily_VSP_pd Subfamily VSP 91-184 4.7e-11 37.0 In-house 82-171 (212) alignment 
Range on Protein: 91-184
Range on HMM: 82-171/212.0
ATTRYYNPEIFIDRdVqyVKVFTPGHVVPPPEVVDKFTAAVSSFKeyNKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYK-PKDALKAFEEARG
 . | |....| .| |  ... .  | ||  | . .||  |  .   .||.. .. .||  | .||| .|| .|.. | ..  |..|. | | | 
cseraydekyfnnr.v..kriliddhnvpkleellvftkevkewl..ekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrt
subfamily_PRL_pd Subfamily PRL 95-185 7.9e-10 33.0 In-house 45-132 (151) alignment 
Range on Protein: 95-185
Range on HMM: 45-132/151.0
YYNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSsfKEYNKDNDMIIGVHCTHGVNRTGYLVCRYLIErEGYKPKDALKAFEEARGY
 |. | . ..... . .      ||| |||... . .   ........ ...|||  |. |.  ||.  ||| .| |..||..   | |  
tydteklekegievldlafddGavPpeevveeWlellk..ekfkeepkstvavhcvaGlGraPvlvalalie.aGmkyedavefirekrrg
subfamily_PTPDC1_pd Subfamily PTPDC1 96-196 2e-07 25.6 In-house 73-168 (182) alignment 
Range on Protein: 96-196
Range on HMM: 73-168/182.0
YNPEIFIDRDVQYVKVFTPGHVVPPPEVVDKFTAAVSSfkeyNKDNDmIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIERENYIED
|..| . .... . ..  . . |.. | .      |..      ...  ..|||  |  ||| |.. ||.  . .....|.|   . |   |.  . .| 
YdlealmeqgiyvynfgwkDygvasleriLdivkvvaf....alqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvel

L
.
v
subfamily_PTPMT1_pd Subfamily PTPMT1 105-185 6e-07 24.1 In-house 73-150 (171) alignment 
Range on Protein: 105-185
Range on HMM: 73-150/171.0
DVQYVKVFTPGHVVPPPevVDKFTAAVSSFKEYNKDNDMiIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGY
.|..... |. .   |   ..| . .|   ... .. .  . |||  |  |.. ||  ||. .|  .|..|||| .. | .
gveqlqlatvDfteapd..leklekgvefiekvaskgkr.vYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRki
0047943 (Phosphotyrosine protein) phosphatases II 106-191 8.2e-10 34.1 In-house 171-259 (273) alignment 
Range on Protein: 106-191
Range on HMM: 171-259/273.0
VQYVKVFtpGHVVP-PPEVVDKFTAAVSSFKEYNKDNdMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIEREN
..| .     | ||  .| . .|  .| .. |....|   . ||| .||.||| ... .|.     .. |  ...|.| . . | . .. ..
fhytgwp..dhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe
0050432 (Phosphotyrosine protein) phosphatases II 108-190 4.1e-10 34.9 In-house 202-285 (308) alignment 
Range on Protein: 108-190
Range on HMM: 202-285/308.0
YVKVFTPGHVVPP-PEVVDKFTAAVSSFKeynkdNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERE
.     | | ||| || . .|  .| ..      ..  | ||| .||.||| ... .|.     .  |  . .|.| . | | . .. .
fhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0051299 (Phosphotyrosine protein) phosphatases II 108-190 2.4e-09 32.5 In-house 187-272 (288) alignment 
Range on Protein: 108-190
Range on HMM: 187-272/288.0
YVKVFTPGHVVPP-PEVVDKFTAAVSSFKEynkDNDMIIGVHCTHGVNRTGYLVCRYLI-----EREGYKPKDALKAFEEARGYPIERE
.     | | ||. || . .|  .| .. .   ...  . ||| .||.||| ... .|.     ...|  . .|.| . | | . .. .
fhytnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 111-190 1.2e-08 30.1 In-house 176-263 (297) alignment 
Range on Protein: 111-190
Range on HMM: 176-263/297.0
VFTPGHVVPP-PEVVDKFTAAVSSFKEYNKDNdMIIGVHCTHGVNRTGYLVCRYLI--------EREGYKPKDALKAFEEARGYPIERE
   | | ||. |. . .|  .| .. ..  ..   . ||| .||.|.| ... .|.        ...|. ...|.| . | |   .. .
tgwpdhgvpespaslldfielvrkvlkllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtl
PTPc_DSPc_SM00012 114-173 9.7e-09 30.7 In-house 11-70 (105) alignment 
Range on Protein: 114-173
Range on HMM: 11-70/105.0
PGHVVPPPEvvDKFTAAVSSFKEYNKDND--MIIGVHCTHGVNRTGYLVCRYLIEREGYKPK
| | || .   |... .. ..|. .....    . ||| .||.|||..|. ... .  .| .
pdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket
DSPc Dual specificity phosphatase, catalytic domain 123-199 3.1e-14 48.0 Pfam-A 55-130 (133) alignment 
Range on Protein: 123-199
Range on HMM: 55-130/133.0
VVDKFTAAVSSFKEYnKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIERENYIEDLLQL
..... .||.  ..  ...   . |||..|..|...|...||....... ..|.....| |.   ......  ||..
iskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 123-199 3.1e-14 48.0 In-house 55-130 (133) alignment 
Range on Protein: 123-199
Range on HMM: 55-130/133.0
VVDKFTAAVSSFKEYnKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIERENYIEDLLQL
..... .||.  ..  ...   . |||..|..|...|...||....... ..|.....| |.   ......  ||..
iskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLley
subfamily_DSP19_pd Subfamily DSP19 126-183 4.7e-06 21.0 In-house 73-130 (152) alignment 
Range on Protein: 126-183
Range on HMM: 73-130/152.0
KFTAAVSSFKEYNKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEAR
..  ..  | |  ...| .. |||  || |.  .|  ||...|  . ..||.   |||
sylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrear
PTPc_motif_SM00404 130-199 1.2e-12 42.9 In-house 72-137 (140) alignment 
Range on Protein: 130-199
Range on HMM: 72-137/140.0
AVSSFkeynKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIERENYIEDLLQL
 ....    ...   . |||..||.|...|.. ||....... ..|.....| |    ...|... |...
fiena....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLiey
subfamily_DSP12_pd Subfamily DSP12 133-193 4.1e-06 21.3 In-house 73-133 (155) alignment 
Range on Protein: 133-193
Range on HMM: 73-133/155.0
SFKEYNKDNDMIIGVHCTHGVNRTGYLVCRYLIEREGYKPKDALKAFEEARGYPIERENYI
.| |   ...  . |||. || |   .|  ||. .|. . ..|||. .|..      |...
dFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFl