Gene DSP14 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP012_AA protein Get Run
SpurP012_AA_9-156 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP14_pd Subfamily DSP14 8-163 2.5e-66 216.5 In-house 3-155 (157) alignment 
Range on Protein: 8-163
Range on HMM: 3-155/157.0
HFHLINEITNSLYLTsAYGASSPTALRAKGITCIINISLsfQTPTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSAS
... ...||.||.|. ...|.|...|..|.||.|||..   ..|..||.||| |...|.| |.|.|  |||..||||..||| ||||.|||.||.|||||
elaalsqitpsLfls.gvaalskellkkkkitliinvtv..elpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAs

SVMAYLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLYGKNSVKMMYT
 ..|||||||.|.|..|. .|||.||.|||| |||||||.||..|.||.||||...
lclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvds
0046846 (Phosphotyrosine protein) phosphatases II 9-154 1.7e-28 95.0 In-house 9-174 (176) alignment 
Range on Protein: 9-154
Range on HMM: 9-174/176.0
FHLINEITNSLYLTSAY----------GASSPTALRAKGITCIINISLSFQTPT---------PKLRDIEFVRIAVDDIPTAQLgVHFDRIADKINSVKK
.  ...|...|.|.|..           |.    |.  |||...|.   ...            .  .|.. .. ..|  . .|  ..... . |... |
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

GGGKTVVHCYAGRSRSASSVMAYLMKY-EHLTLKQAHVHVKSRRP-VIRPNPGFWKQLITYEHRLYG
 ||...|||.||..|..  |.|||...  .|.. .|  .|...||  . ..|.....|  .|..|..
eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
0051429 (Phosphotyrosine protein) phosphatases II 9-152 5.2e-17 57.9 In-house 9-224 (272) alignment 
Range on Protein: 9-152
Range on HMM: 9-224/272.0
FHLINEI-----TNSLYLTSAY---GASSPTALRAKGITCIINISLSF---QTP-TPKLRDIEFVRIAVDDIPTAQLGVHF-------------------
.  ..        . ||....     | .  .|.  ||..|...   .   . .  . . .|..... . |  . .  ...                   
ardvggygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrel

-----------------------------DRIADKINSVKKgGGKTVVHCYAGRSRSASSVMAYLMKyEHLT--------------LKQAHVHVKSRRPV
                             . . . .. . . ||. .|||.||..|..  |...|.  . ..              | .|  .....|| 
lltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpg

IRPNPGFWKQLITYEHRL
..........|  ..  |
avqteeqylflyeallel
subfamily_DSP3_pd Subfamily DSP3 10-154 3.8e-32 105.2 In-house 9-159 (162) alignment 
Range on Protein: 10-154
Range on HMM: 9-159/162.0
HLINEITNSLYLTSAYGASSPTALRAKGITCIINISLS-F-Q--TPTPKLR--DIEFVRIAVDDIPTAQLGVHFDRIADKINS-VKKGGGKTVVHCYAGR
. ..|....||.. .. |.  . |.. ||| ..| . . | .  | .   .  .|... . ||| |...| ..|.. |. |.. ...  || .||| .| 
kevdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGv

SRSASSVMAYLMKYEHLTLKQAHVHVKSRRPvIRPNPGFWKQLITYEHRLYG
||||  |.|||| ....||..|  .|...|  |.|| || |||......|  
sRsatlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeelkr
0041856 (Phosphotyrosine protein) phosphatases II 11-160 4.6e-32 106.4 In-house 18-180 (182) alignment 
Range on Protein: 11-160
Range on HMM: 18-180/182.0
LINEITNSLYLTSAYG--------------ASSPTALRAKGITCIINISlSFQTPTPKLRD--IEFVRIAVDDIPTAQlgvhFDRIADKINSVKKGGGKT
 ...|...||| | ..              |.  . |.  |||.|.|.. ... .  .| .  |..... ..| ..      .| . | |. |.. ||..
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpv

VVHCYAGRSRSASSVMAYLMKYEHLTLKQAHVHVKSRRP--VIRPNPGFWKQLITYEHRLYGKNSVKM
.||| ||..|... |.|||||. ...| .|  .|.||||  ||.|| .|. ||. .|..|..|. .|.
lVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpkl
subfamily_DSP6_pd Subfamily DSP6 11-152 7.3e-28 91.1 In-house 13-154 (158) alignment 
Range on Protein: 11-152
Range on HMM: 13-154/158.0
LINEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVM
.  ||.. ||| ||  ||   .|.  .|  ..|.    .    .  ......|...|  ...|  .|    . |.  ..   | .|||.|| |||   ..
fpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtl

AYLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRL
|||||...|.|..|.  ||.|.. | ||  | .||. .|..|
aylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0045098 (Phosphotyrosine protein) phosphatases II 11-154 4.1e-27 90.7 In-house 21-273 (278) alignment 
Range on Protein: 11-154
Range on HMM: 21-273/278.0
LINEITNSLYLTSAY-----------------------------------------GASSPTALRAKGITCIINIS------------------------
 ..|||..||| ...                                          |.    |.  |||.|...                         
ipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygd

-----------------------LS---FQTPTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKK--------------GGGKTVVHCYAGRSRS
                       |.      .. ... . .. .   ..|.  .  .|... . |... |              .||...|||.|| .|.
ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRt

ASSVMAYLMKYE---HLTLKQAHVHVKSRRPV-IRPNPGFWKQLITYEHRLYG
.  |.||||..    ...| .|  ...|.||  . .|......|. .. .|. 
GtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_DSP1_pd Subfamily DSP1 12-153 5.6e-39 127.8 In-house 18-157 (163) alignment 
Range on Protein: 12-153
Range on HMM: 18-157/163.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKlrDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMA
...|.. ||| |.. ||    |...||| |.|.| . .   ..    |. .. ..| |.|.. ..|... . |..||| .||  .|| || |||.. ..|
vekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

YLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLY
|||| ....|..|.  ||.||..|.|| || .||..||..| 
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0044763 (Phosphotyrosine protein) phosphatases II 12-157 7.5e-37 122.0 In-house 23-175 (178) alignment 
Range on Protein: 12-157
Range on HMM: 23-175/178.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQT-------PTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVK-KGGGKTVVHCYAGRS
..||.. |||.|.. |. .  |.. |||.|.|..  .           |.  .|....| ..| .. .|  ||... . |...  . ||...|||.||..
aseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RSASSVMAYLMKYEHLTLKQAHVHVKSRRPvIRPNPGFWKQLITYEHRLYGKNS
||.. |.|||||. .|.| .|  .|..||| | ||||...||. .| ||.....
RsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkesd
PTPc_motif_SM00404 12-150 3.6e-36 119.1 In-house 2-139 (140) alignment 
Range on Protein: 12-150
Range on HMM: 2-139/140.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPtPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMA
...|.. ||| |.. |..|  | ..||| .||.. . . .  .  ......| .||  ...|  ..|...| |....| ||| .|||.|| ||||. ..|
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEH
|||.|..|.|..|   ||.||| |.|| .|..||| || 
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP19_pd Subfamily DSP19 12-152 9.9e-36 117.4 In-house 12-150 (152) alignment 
Range on Protein: 12-152
Range on HMM: 12-150/152.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPtpKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMA
. |....|||.|  .|.. ..|. |.|| |.|..   ..     .|.... | . | | ..|  ..... | |.....  |  .||| ||.||||| |.|
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnv..fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvvia

YLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRL
|||| |.|.|..|   |.. || |.|| ||.||| .||..|
ylmkkeelsleealelvrearpcikPneGFikqLkeyeael
0048179 (Phosphotyrosine protein) phosphatases II 12-152 2.9e-34 113.2 In-house 4-144 (144) alignment 
Range on Protein: 12-152
Range on HMM: 4-144/144.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMA
..||...||| | . |..   |.. |||..||.. ..  . ..   |..... ..| .. .|  ..... . |... . ||...|||.||..|... |.|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRL
||||...|.|..|  .|.|||| . ||||....|. ||..|
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_DSP10_pd Subfamily DSP10 12-155 7.8e-34 110.8 In-house 14-156 (159) alignment 
Range on Protein: 12-155
Range on HMM: 14-156/159.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKlRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMA
. ..   |.| |. .|.. .||.  .||...|.  |  .   .  .... || | |  . .|  .|.   . |. ..| | . .||| || ||||. |.|
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLYGK
||||. .|.|..|. .||..||.| || .|  ||. .|..|  .
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
0048076 (Phosphotyrosine protein) phosphatases II 12-153 1.9e-33 110.5 In-house 4-143 (145) alignment 
Range on Protein: 12-153
Range on HMM: 4-143/145.0
INEITNSLYLTSAYGASSPTALRAKGITCIINIslSFQTPTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMA
..||...||| | . |..   |.  |||...|.  .  .. ..  .|..... ..| .. .|  ..... . |... | ||...|||.||..|... |.|
pseilpglylgslptaldlellkdlgittvlnl..tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLY
|||......| .|  .|.|.|| . ||||....|. .|..|.
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelell
subfamily_DSP8_pd Subfamily DSP8 12-153 9.4e-31 100.5 In-house 15-155 (159) alignment 
Range on Protein: 12-153
Range on HMM: 15-155/159.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPtPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMA
...|.. ||| |   . | ..|...||. ..|.| |  ..  .|.. .|.|. | |  . .|   ||.  . |. .|.  |. .||..||.||||. ..|
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkl.eelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLY
|.||. ...| .|. .||..||.| ||  | .||. ||..| 
yimktlemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_DSP12_pd Subfamily DSP12 12-153 8.4e-29 95.0 In-house 2-144 (155) alignment 
Range on Protein: 12-153
Range on HMM: 2-144/155.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLS-FQTPTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVM
...|.. ||| ..  . ... |.  .|| .. .     .. ..|   ..   | ..| |.. .  |.|.. | |..  . .|. .|||.|| |||.. |.
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AYLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLY
|||||.|.| |..|.  ||. .| |.|| || .||  .|.  .
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgc
subfamily_DSP15_pd Subfamily DSP15 12-151 1.9e-27 90.2 In-house 2-138 (151) alignment 
Range on Protein: 12-151
Range on HMM: 2-138/151.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLsfqTPTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMA
|... . |||.    ..  . |. | || |....     . . |.|||.  ||..| | |.|  .|.   . | . .  ... .||| || |||.  |.|
iskvlpglylgnfrdskdeelLkeknithilsvhd...nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvva

YLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHR
|||   .|  ..|   .| .| |  || || .||  ||. 
YlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
0049260 (Phosphotyrosine protein) phosphatases II 12-151 2e-25 84.7 In-house 8-148 (152) alignment 
Range on Protein: 12-151
Range on HMM: 8-148/152.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKL-RDIEFVRIAVDDIPTAQLGVHFDRIADKINS-VKKGGGKTVVHCYAGRSRSASSV
 .|..  .....   |.    |.  |||.|...   .  . .|  . |.. .. ..| .. .|  ... . . |.   .. ||...|||.|| .|..  |
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

MAYLMKyEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHR
.||||.  ...|..|  .|...||.. ||||....|  .|  
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl
0036282 (Phosphotyrosine protein) phosphatases II 12-152 4e-23 77.4 In-house 12-169 (174) alignment 
Range on Protein: 12-152
Range on HMM: 12-169/174.0
INEITNSLYLTSAYGAsSPTALRAKGITCIINISLSFQT-------------PTPKLRDIEFVRIAVDDIPTAQLGVhFDRIADKINSVKKG--GGKTVV
...||. |.....  |     |.  |||....   ...                ..  .|..... ..|  .  | . .... . .... .   ||...|
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCYAGRSRSASSVMAYLMKYEHL-TLKQAHVHVKSRR---PVIRPNPGFWKQLITYEHRL
|| ||..|..  |.||||.. .| .| .|  .|...|   | . ..|.....|  .|  |
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0040439 (Phosphotyrosine protein) phosphatases II 12-153 1.2e-22 76.2 In-house 29-246 (249) alignment 
Range on Protein: 12-153
Range on HMM: 29-246/249.0
INEITNSLYLTSAYGASSPTA------------------------LRAKGITCIINISLSFQT-------------------------------------
. .|...|.|.. . ||  .                         |.  |||.|....  ..                                      
klsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrt

----PTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKK------GGGKTVVHCYAGRSRSASSVMAYLM-----KYEHLTLKQAHVHVKSRRPVI
    .. .  ...   | . |.|  ..  .|. . | |. |.|       ||...||| || .|..  ..||||     |. ...|..|  ...|.|| .
leltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpga

RPNPGFWKQLITYEHRLY
 .||.....|. ....|.
vqnpeqyrflyeallell
0051082 (Phosphotyrosine protein) phosphatases II 12-148 2.1e-22 74.8 In-house 8-149 (151) alignment 
Range on Protein: 12-148
Range on HMM: 8-149/151.0
INEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTP----KLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKG-GGKTVVHCYAGRSRSA
.. .|. ||....  |     |.  ||..|.|.   . ...     .  .||...| ..| |. .| ..|| ... .. . .  .|...||| ||..|..
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

SSVMAYLMKyEHLTLKQAHVHVKSRRP-VIRPNPGFWKQLITY
  |..|||. ....| .|  .....|| |..|| .|..||. .
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_STYX_pd Subfamily STYX 12-161 4.9e-20 65.3 In-house 12-166 (166) alignment 
Range on Protein: 12-161
Range on HMM: 12-166/166.0
INEITNSLYLTS--AYGASSPTALRAKGITCIINISLSFQTP--TPKLR-DIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSA
..||   |.|    |   |    |. .||| |. |  . ..    |... .. .. . | | .. ..  .. .. . |..  . ||| .||  || ||||
mqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

SSVMAYLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLYGKNSVKMM
. |.||.|.   |  ..|. .|. ||  | || || .||  ||     | ..|..
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakltikll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 13-155 3.4e-28 92.5 In-house 121-261 (263) alignment 
Range on Protein: 13-155
Range on HMM: 121-261/263.0
NEITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKLrdIEFVRI-AVDDIPTAQLGVHFDRIADKINSVKKGGGkTVVHCYAGRSRSASSVMA
.|| . |.| .   |   . |. .|.| |.     |.   |||    .. |  ..|.. |..  ||...   |.. .| ||  .||| || |||.. |..
deiidklflGgldsannksilkdlgvthillavadfePlfPkl..fkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvis

YLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLYGK
||||...|..|.|   |...|| |.||||| .||  ||. |.  
ylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfct
0043147 (Phosphotyrosine protein) phosphatases II 13-153 3.6e-27 90.6 In-house 20-161 (172) alignment 
Range on Protein: 13-153
Range on HMM: 20-161/172.0
NEITNSLYLTSAYGASSPTALRAKGITCIINISlSF--QTPTPKLRDIEFVRIAVDDIPTAqLGVHFDRIADKINS--VKKGGGKTVVHCYAGRSRSASS
...   ..... . |.    |. .|||.|.|.  ..   ..  .  .|.. .. ..| ..  |  ..... . |..  ... ||...|||.|| .|..  
drfiatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

VMAYLMKyEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLY
|.||||. ..|.| .|  .|...|| . .||.....|  .|..|.
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
0042113 (Phosphotyrosine protein) phosphatases II 13-152 9.7e-25 82.8 In-house 48-242 (245) alignment 
Range on Protein: 13-152
Range on HMM: 48-242/245.0
NEITNSLYLTSAYGASSPT----ALRAKGITCIINISLSFQ--------------------------------------------TPTPKLRDIEFVRIA
 .||. ...|..  ....      |.  |||.|....  .                                                ... .| . .. 
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

VDDIPTAQLGVHFDRIADKINSVKK--GGGKTVVHCYAGRSRSASSVMAYLM-----KYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRL
..| ... |  ..... . .... .  ..|...||| ||..|..  ..||||     |.  ..| .|  ...|.|| ....|.....|. ... |
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Slingshot_pd Subfamily Slingshot 14-154 1.4e-32 106.5 In-house 21-159 (169) alignment 
Range on Protein: 14-154
Range on HMM: 21-159/169.0
EITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKlrDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYL
.| . .|| | . ||    |. .|.. |.|..   .   |.  ..|...| | | ....|  ....  . |. .|| | | .|||  | |||||.|.|| 
kifdhvylGsewnasnleelkengveyilnvtkeidnffpe..kfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviaya

MKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLYG
||  .|.|..|. .||.|| ||.||.||.||| .||  |  
mkeyglsleealeyvkerrsvikPnkgflkqleeyeGilea
PTEN_1 14-152 2.2e-26 87.9 In-house 43-191 (196) alignment 
Range on Protein: 14-152
Range on HMM: 43-191/196.0
EITNSLYLTSAYGA-SSPTALRAKGITCIINISLSFQT----PTP---KLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKK--GGGKTVVHCYAGRS
||  .||. |.  . .    | ..|||...| |. . .     ..   . ...|. .. ..| ..  |  .|| ... |.....   |.. .||| ||..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSASSVMAYLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRL
||.  |.||||... || ..|  .|...||...||......|. |...|
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0037934 (Phosphotyrosine protein) phosphatases II 14-152 1.6e-24 82.3 In-house 41-241 (243) alignment 
Range on Protein: 14-152
Range on HMM: 41-241/243.0
EITNSLYLTSA--------YGASSPTALRAKGITCIINISLSF------------------------------------------Q-TPTPKLRDIEFVR
..|. |..|..        . ||    |   |||.|...   .                                            .. ... .| . .
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

IAVDD----IPTAQLGVHFDRIADKINS-----VKKGGGKTVVHCYAGRSRSASSVMAYLMKYE-HLTLKQAHVHVKSRRPV-IRPNPGFWKQLITYEHR
... |      ...|  ..| . . |..     . ..||...|||.||..|..  ..||||..  ...| .|  .....||  . ..|.....|. ... 
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle

L
|
l
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 15-151 6.9e-19 61.7 In-house 6-151 (154) alignment 
Range on Protein: 15-151
Range on HMM: 6-151/154.0
ITNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKL----RD---IEFVRIAVDDIPTA----QLGVHFDRIADKINSVKKggGKTVVHCYAGRS
 .  ||..|   |     |. | |. |.|...  .   ..      |   ||.... . | .      .|   |. | |.| .|..  .| .||. .| |
eaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggven..nkvlvhsdkGvs

RSASSVMAYLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHR
|||. ...|||.  ...| .| . .|. |..|.|| || |||  .| .
rsaallisylmdklkislslalellkdsryiikPnqGflkqleifeke
subfamily_MKPLT_pd Subfamily MKPLT 16-155 1.2e-31 103.4 In-house 26-163 (164) alignment 
Range on Protein: 16-155
Range on HMM: 26-163/164.0
TNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKlrDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLMK
 . |||  |  | . . |..  || |.|.|   .   ||   .|. .. |.| .. ||. ...|.|. . .  ..||. .|||  |.|||.|  .|.|.|
edtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLik

YEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLYGK
..  |||.|. ..| || ...|| || ||| ..|. ..||
skgwtlkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_MKPLV_pd Subfamily MKPLV 16-155 1.2e-31 103.4 In-house 26-163 (164) alignment 
Range on Protein: 16-155
Range on HMM: 26-163/164.0
TNSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKlrDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLMK
 . |||  |  | . . |..  || |.|.|   .   ||   .|. .. |.| .. ||. ...|.|. . .  ..||. .|||  |.|||.|  .|.|.|
edtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLik

YEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLYGK
..  |||.|. ..| || ...|| || ||| ..|. ..||
skgwtlkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_STYXL1_pd Subfamily STYXL1 17-155 3e-19 62.8 In-house 17-156 (157) alignment 
Range on Protein: 17-155
Range on HMM: 17-156/157.0
NSLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKLRD-IEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLMK
. |||     | .|.  .   .   .|.|   .     . |  . ..|||.| . |.|  ..... . |.. || |   .|    | ||||. ..|||| 
gklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

YEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLYGK
....|||.|. ..|  .. ..|| .| .||  .|..|.|.
skkitlkkaykylkkCkenvkPnrafveqlseWekqllge
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 18-151 2e-29 96.0 In-house 14-146 (148) alignment 
Range on Protein: 18-151
Range on HMM: 14-146/148.0
SLYLTSAYGASSPTALRAKGITCIINISLSFQTPTPKlRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLMKYE
 |.| |   |..  ||.| |.| |.| . . . .  . | ||.. .|.|| |  .|   |. |.. .. .|. |.. .||.  |.|||.  ....|....
fLFlGskksaadlealkalgvtrivnatkerdnaldq.rgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfk

HLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHR
. .||.|   |||.|. ..||.|| |||  .|..
rvslkealalvkskrryvdpnlgfLkqLaeleqa
DSPc Dual specificity phosphatase, catalytic domain 19-150 8.4e-34 111.3 Pfam-A 1-132 (133) alignment 
Range on Protein: 19-150
Range on HMM: 1-132/133.0
LYLTSAYGASsPTALRAKGITCIINISLSFQT-PTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLMKYE
||| |.. || .. | ..||| .||.. . .   . |  .||..|| |.|  ....  ..... . |..... |.| .|||.|| ||||. ..|||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

HLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEH
.|.|..|  .||.||. |.|| ||..||. || 
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 19-150 8.4e-34 111.3 In-house 1-132 (133) alignment 
Range on Protein: 19-150
Range on HMM: 1-132/133.0
LYLTSAYGASsPTALRAKGITCIINISLSFQT-PTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLMKYE
||| |.. || .. | ..||| .||.. . .   . |  .||..|| |.|  ....  ..... . |..... |.| .|||.|| ||||. ..|||||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

HLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEH
.|.|..|  .||.||. |.|| ||..||. || 
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 19-152 4.3e-23 75.0 In-house 6-141 (145) alignment 
Range on Protein: 19-152
Range on HMM: 6-141/145.0
LYLTSAYGASSPTALRAKGITCIINISLS--FQTPTPKLRDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLMKY
||  ||  |.. ..|.  ||. |.|.. .    .   | ..|| . |. .|. . .|  ||| ..| |.  |. |    ||| || ||| .  .|.||||
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

EHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRL
  .|| .|   |.|.|    ||  | |.|.  |..|
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0038934 (Phosphotyrosine protein) phosphatases II 28-153 1.8e-20 68.8 In-house 47-177 (194) alignment 
Range on Protein: 28-153
Range on HMM: 47-177/194.0
SSPTALRAKGITCIINISLSFQTPTPKLR---DIEFVRIAVDD---IPTAQLGVHFDRIADKINSvKKGGGKTVVHCYAGRSRSASSVMAYLMKYEHLTL
 .   |. ......|... .  .  |..    .||.... . |   .|. ..  .| ...|.... .. ||. .|||.||..|..  | |||... ....
vrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefln.edpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsa

KQAHVHVKSRRPVIRPNPGFWKQLITYEHRLY
..|  .....|| . ||......| .. . |.
eeAialfrekRpgaipnqdyleallkrykelr
0045450 (Phosphotyrosine protein) phosphatases II 33-153 4.3e-21 71.4 In-house 127-304 (307) alignment 
Range on Protein: 33-153
Range on HMM: 127-304/307.0
LRAKGITCIINISLSFQTPTP--------------------------KLRDIEFVRIAVDDI-----------------PTAQLGVHFDRIADKINSVKK
|. .|.|.|.... ..    .                          .| ..   .. | |                  |  ..  .|. . | |. |.|
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

------GGGKTVVHCYAGRSRSASSVMAYLMKYEH--------LTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLY
      .||...||| || .|... ..||||.. .        ..| .|  .....|| . .||.....|. ... |.
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0049772 (Phosphotyrosine protein) phosphatases II 34-155 1.6e-29 99.1 In-house 167-276 (314) alignment 
Range on Protein: 34-155
Range on HMM: 167-276/314.0
RakgitciinislSFQT--PTPKLRDIEFVRIAVDDiPTAQLGVHFDRIADKINSVkKGGGKTVVHCYAGRSRSAS-SVMAYLMKYEHLTLKQAHVHVKS
.            . ..  . .. . |...|| |.| ..| |  .||.. . |... . ||...||| ||..|...  |.|||||. ...|..|  .|..
k............eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrl

RRPvIRPNPGFWKQLITYEHRLYGK
.|| |.|||||..||. || .|. .
kRp.inpnpgfieqleqyefileal
subfamily_DSP23_pd Subfamily DSP23 34-133 5.5e-08 27.6 In-house 28-126 (148) alignment 
Range on Protein: 34-133
Range on HMM: 28-126/148.0
RAKGITCIINISLSFQTPTPKLRDIEFVRIAVDDI--PTAQLGVHFDRIADKINSvkKgGGKTVVHCYAGRSRSASSVMAYLMKYEHLTLKQAHVHVKSR
  .|.  .. ..   . ..    .. .||. .||   |. .  |.| |. .. ..  | .    |||  || |. . .  ||.| ..|.  .|   |. .
ldlgvrylvslteegrphveatpnltlvrlriddyhppaleqvvefvrvveeaee..k.neavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

RP
||
rp
0040438 (Phosphotyrosine protein) phosphatases II 37-156 1.8e-19 65.6 In-house 110-279 (317) alignment 
Range on Protein: 37-156
Range on HMM: 110-279/317.0
GITCIINISLSF------------------------------QTPTPKLRDIEFVRI----------------AVDDIPTaqlgvHFDRIADKINSVKKG
|.|.|...  ..                              . .  .|| .|..                    ...|      ..| . | .. |.. 
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp.....spdllldfleavrea

----GGKTVVHCYAGRSRSASSVMAYLM-----KYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRLYGKN
    ||...||| || .|... ..||||     |........|  .....|| . ..|.....|..... .. ..
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_MSG5_pd Subfamily MSG5 47-153 1.2e-15 51.0 In-house 62-161 (165) alignment 
Range on Protein: 47-153
Range on HMM: 62-161/165.0
SFQTPTpklrdIEFVRIAVDDipTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLI
 .. |.     ...  |  .   ....   . |..  | . .  . | .|||  | ||||| ..||.|||  |.|..|. ..||.   | |. |.  ||.
ellvpa.....vkyyhieweh..dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlm

TYEHRLY
 .|  | 
ewevals
0043336 (Phosphotyrosine protein) phosphatases II 50-151 5.3e-17 57.6 In-house 170-275 (278) alignment 
Range on Protein: 50-151
Range on HMM: 170-275/278.0
TPTPKLRDIEFVRIAVDDIPTaQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLM-----KYEHLTLKQAHVHVKSRRPVIRPNPGFWKQ
 .. . . . .. .  ...|. .|  ..| . . .. ... .|...||| || .|..  ...||.     |. ...| .|  .....|| . ..| ....
gesrtvthyhylgwpdhgvpe.slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf

LITYEHR
|. ... 
lyealle
0046845 (Phosphotyrosine protein) phosphatases II 56-139 2.2e-10 35.9 In-house 168-260 (284) alignment 
Range on Protein: 56-139
Range on HMM: 168-260/284.0
RDIEFVRIAVDDIPT-AQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLMKYE--------HLTLKQAHVHVKSRRPVIRPNP
. . .  .  ...|. ..  ..| |.......  .|||..|||| || .|..  ....|...         .... .|  .....||    ..
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
subfamily_PTPDC1_pd Subfamily PTPDC1 56-133 4.3e-08 27.8 In-house 81-156 (182) alignment 
Range on Protein: 56-133
Range on HMM: 81-156/182.0
RDIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGggKTVVHCYAGRSRSASSVMAYLMKYEHLTLKQAHVHVKSRRP
..| .  .. .|  .| |   .| .     ....|  |. |||.||. |    . .||.  ..|| ..|   |.|.||
qgiyvynfgwkDygvasleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
subfamily_PTPMT1_pd Subfamily PTPMT1 57-152 2.9e-17 57.6 In-house 73-168 (171) alignment 
Range on Protein: 57-152
Range on HMM: 73-168/171.0
DIEFVRIAVDDIPTAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHRL
..|....|. |.  |    .  .  . |..|.. | .  ||| |||.|||. | .|||| |.|....|. ..|..|. || .   ||.|  ||. |
gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
0039614 (Phosphotyrosine protein) phosphatases II 58-154 2e-19 65.7 In-house 186-290 (297) alignment 
Range on Protein: 58-154
Range on HMM: 186-290/297.0
IEFVRIAVDDIPTAQLGVHFDRIADKINSVKK---GGGKTVVHCYAGRSRSASSVMAYLM-----KYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYE
  |  .   |  . ..  ..... ...... .   .||...||| || .|... ..||||     |. ......|  .....|| ....|.....|. ..
thfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal

HRLYG
. |. 
lellk
0036941 (Phosphotyrosine protein) phosphatases II 63-162 8.4e-21 70.0 In-house 173-286 (297) alignment 
Range on Protein: 63-162
Range on HMM: 173-286/297.0
IAVDDIPTAQLGVHFDRIADKINSVKK------GGGKTVVHCYAGRSRSASSVMAYLM--------KYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITY
. . ..|   .  ... . | |. |.|      .||...||| || .||.. ..|.||        |.. .....|  .....|| . ........|. .
fhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea

EHRLYGKNSVKMMY
.  |. |. .|...
llellkkkltkepl
0047943 (Phosphotyrosine protein) phosphatases II 64-146 1.6e-13 46.2 In-house 177-265 (273) alignment 
Range on Protein: 64-146
Range on HMM: 177-265/273.0
AVDDIP-TAQLGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLM-----KYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLI
  ...| . .  ..| ....|...  ...|..|||| || .|... ....|.     |.  .....|  ...|.|| . ..| ....|.
pdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 73-141 6.7e-11 37.6 In-house 201-274 (288) alignment 
Range on Protein: 73-141
Range on HMM: 201-274/288.0
LGVHFDRIADKINSVKKGGGKTVVHCYAGRSRSASSVMAYLM-----KYEHLTLKQAHVHVKSRRPVIRPNPGF
.   .| . . ... ..||| .|||| || .|..  ....|.     | ..... .|  .....|| . ..|  
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeq
DUF1706 Protein of unknown function (DUF1706) 76-157 6.1e-06 12.2 Pfam-A 17-97 (166) alignment 
Range on Protein: 76-157
Range on HMM: 17-97/166.0
HFDRIADKINSVKKGGGKTVVHCYaGRSRSASSVMAYLMKYEHLTLKQAHVHVKSRRpVIRPNPGF-WKQLITYEHRLYGKNS
.|... ..|.|...   .. ..   .| .| . |.|||.   .| ||  . . . .. |  |..|. |.||  . ...| | .
nfeklikeiesipeelkdekfeeg.erdksvrdvlayllgWheLllkWeedeqagke.vkfpaegykWnqlgelnqefykkyq
0050432 (Phosphotyrosine protein) phosphatases II 77-140 3.8e-10 35.0 In-house 219-286 (308) alignment 
Range on Protein: 77-140
Range on HMM: 219-286/308.0
FDRIADKINSVKkGGGKTVVHCYAGRSRSASSVMAYLM-----KYEHLTLKQAHVHVKSRRPVIRPNPG
. .. ......  .||..|||| || .|..  ....|.     |  .... .|  .....||   ..| 
lldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0048567 (Phosphotyrosine protein) phosphatases II 79-151 4.8e-09 30.8 In-house 62-137 (157) alignment 
Range on Protein: 79-151
Range on HMM: 62-137/157.0
RIADKINSVKKGGGKTVVHCYAGR---SRSASSVMAYLMKYEHLTLKQAHVHVKSRRPVIRPNPGFWKQLITYEHR
.. ........ |.. .|||.||.   .|.|  . .||... ..|  .|  ...  || . | .  .  | .|.  
klnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynlt
PTPc_DSPc_SM00012 79-116 7.2e-06 21.5 In-house 24-64 (105) alignment 
Range on Protein: 79-116
Range on HMM: 24-64/105.0
RIADKINSVKKG---GGKTVVHCYAGRSRSASSVMAYLMKY
.. ......|.    .. .|||| || .|..  |.....  
ellravkknknksesskpvvVhCsaGvgRtgtfvaldillq
subfamily_Laforin_pd Subfamily Laforin 85-135 1.8e-06 21.0 In-house 104-154 (183) alignment 
Range on Protein: 85-135
Range on HMM: 104-154/183.0
NSVKKGGGKTVVHCYAGRSRSASSVMAYLMKYEHLTLKQAHVHVKSRRPVI
 .. . | .  ||| ||  ||.. |  .|.   . .|..   .. ..|||.
hallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv