Gene DSP3-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP016_AA protein Get Run
SpurP016_AA_1-105 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPMT1_pd Subfamily PTPMT1 1-84 6.5e-19 63.0 In-house 68-150 (171) alignment 
Range on Protein: 1-84
Range on HMM: 68-150/171.0
EYQDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQEDgKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPI
|.. .....  |.. |. .|   .. . .|.||..  .. . .| .|| || .||||....||| .. .. .||.....|||.|
ewkklgveqlqlatvDfteapdleklekgvefiekvaskgk.rvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRki
subfamily_DSP3_pd Subfamily DSP3 2-96 1.7e-49 161.6 In-house 58-152 (162) alignment 
Range on Protein: 2-96
Range on HMM: 58-152/162.0
YQDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPIGPNEGFLKQLWL
|.|..|||.||.|.||| ....|.|.||.|||||||.|..||||.|||.|.|||||...||||||| ||..||.||||||| |.|||||||||  
ykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLae
0049772 (Phosphotyrosine protein) phosphatases II 2-96 2.7e-32 108.2 In-house 176-268 (314) alignment 
Range on Protein: 2-96
Range on HMM: 176-268/314.0
YQDTNIKYCGLPVNDvPGANMKKHFNTAVKFIDEAleQEDGKVLIHCVAGFSRSAT-IAIAYLMIRRGMTAQEATRTVRKKRPIGPNEGFLKQLWL
.....|||. .|| | ..|.  ..|. ...||.||  ...|.||.|| || .|..| ...||||...|....|| . ||.||||.||.||..|| .
ferlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleq
0044763 (Phosphotyrosine protein) phosphatases II 2-96 7.1e-32 105.9 In-house 71-165 (178) alignment 
Range on Protein: 2-96
Range on HMM: 71-165/178.0
YQDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPIGPNEGFLKQLWL
.....|.|. .|. | .  .. .||  .|.||.|||....|.||.|| ||..||.|...||||...|....|| . ||..||| ||.|.|.|| .
peeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLye
PTEN_1 2-94 7.1e-29 96.0 In-house 90-184 (196) alignment 
Range on Protein: 2-94
Range on HMM: 90-184/196.0
YQDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQE-DGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKR-PIGPNEGFLKQL
... ...|  .|..| .  .. ..|  ...||. .|...  ..||.|| || .||.|...|||| ....||.|| . ||.|| |..|| .....|
ffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerl
subfamily_DSP10_pd Subfamily DSP10 2-94 3.7e-28 92.4 In-house 54-146 (159) alignment 
Range on Protein: 2-94
Range on HMM: 54-146/159.0
YQDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEAlEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP-IGPNEGFLKQL
......||  .||.|    |.|..|. |..||.||  ... .||.|| || |||||..||||| ..... ..| . |..||| | || .|. ||
feeealkYkripvsDtskqnlkqyfeealefieea.rkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqL
0048076 (Phosphotyrosine protein) phosphatases II 2-96 5.6e-26 86.4 In-house 43-137 (145) alignment 
Range on Protein: 2-96
Range on HMM: 43-137/145.0
YQDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQEdGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPI-GPNEGFLKQLWL
. ...|.|. ||. | .  .. ... ....||.|||... |.||.|| || .|..|...||||...|....|| . ||..||.  ||.|.|..| .
lerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflye
0043147 (Phosphotyrosine protein) phosphatases II 2-95 1.9e-25 85.0 In-house 61-154 (172) alignment 
Range on Protein: 2-95
Range on HMM: 61-154/172.0
YQDTNIKYCGLPVNDVPGAnMKKHFNTAVKFIDE-ALEQEDGKVLIHCVAGFSRSATIAIAYLMIrRGMTAQEATRTVRKKRP-IGPNEGFLKQLW
.....|.|. ||. | .   . ...  ...|||| ......|.||.||.||..|..|...||||. .|....|| ..||.||| . .|......| 
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 2-96 1.1e-24 82.6 In-house 72-167 (176) alignment 
Range on Protein: 2-96
Range on HMM: 72-167/176.0
YQDTNIKYCGLPVNDVPGANMkKHFNTAVKFIDEALEQEdGKVLIHCVAGFSRSATIAIAYLMIR-RGMTAQEATRTVRKKRP--IGPNEGFLKQLWL
... .|.|. ||. |    .. ... ....||.|||..  |.||.||.|| .|..|...|||... .|....|| ..||..||  . ........|  
leklgiqylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflye
0051082 (Phosphotyrosine protein) phosphatases II 2-95 4.4e-22 73.7 In-house 53-147 (151) alignment 
Range on Protein: 2-95
Range on HMM: 53-147/151.0
YQDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLMIrRGMTAQEATRTVRKKRP--IGPNEGFLKQLW
.....|... .|. | |  ..  .|.....|....|....|.||.|| || .|..|....|||. .|....|| . .|.|||  . ||..||.||.
lpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_Slingshot_pd Subfamily Slingshot 2-95 1.1e-21 70.9 In-house 58-151 (169) alignment 
Range on Protein: 2-95
Range on HMM: 58-151/169.0
YQDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEqEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPI-GPNEGFLKQLW
. . ...|. . | | . ... |..|.. |||..| . .. |||.||  | ||||.. ||| | . |.. .|| . |...| .  ||.|||||| 
ffpekfeylnirvydeeetdllkywnetykfiekakk.kgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqle
subfamily_PTPDC1_pd Subfamily PTPDC1 2-83 1.6e-13 45.5 In-house 78-156 (182) alignment 
Range on Protein: 2-83
Range on HMM: 78-156/182.0
YQDTNIKYCGLPVNDVPGANMKKHFnTAVKFIDEALEQEdgKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP
.....| .. .. .|   | ... . . || .. ||...  || .|| ||  |   .  .||.  . .||..| ..||.|||
lmeqgiyvynfgwkDygvasleriL.divkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
subfamily_Laforin_pd Subfamily Laforin 2-84 2.4e-07 23.8 In-house 72-153 (183) alignment 
Range on Protein: 2-84
Range on HMM: 72-153/183.0
YQDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEqEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPI
|..  . |  ||..|.   .  . .  || ..   || .  .| .|| ||  ||..|   .|.   | . .     .  |||.
ykeeglayiwlptedlstesrvenlpqavyllhalle.kghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpv
subfamily_DSP11_pd Subfamily DSP11 2-82 2.9e-07 24.6 In-house 75-157 (178) alignment 
Range on Protein: 2-82
Range on HMM: 75-157/178.0
YQDTNIKYCGL--PVNDVPGANMKKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKR
..|...||  |  | ..||  .. |.|. |||   |  ...|  . .||  |  |.  .   ||. . |. ...| ..  . |
ltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
DSPc Dual specificity phosphatase, catalytic domain 3-95 6.5e-30 98.7 Pfam-A 36-128 (133) alignment 
Range on Protein: 3-95
Range on HMM: 36-128/133.0
QDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEAlEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP-IGPNEGFLKQLW
....|.| ..||.|   ... |... ||.||..| ||. .|||.|| || |||||..||||| .......|| . |...|. | ||.|||.|| 
kkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLl
DSPc Dual specificity phosphatase, catalytic domain 3-95 6.5e-30 98.7 In-house 36-128 (133) alignment 
Range on Protein: 3-95
Range on HMM: 36-128/133.0
QDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEAlEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP-IGPNEGFLKQLW
....|.| ..||.|   ... |... ||.||..| ||. .|||.|| || |||||..||||| .......|| . |...|. | ||.|||.|| 
kkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLl
subfamily_DSP1_pd Subfamily DSP1 3-95 1.2e-26 87.7 In-house 59-150 (163) alignment 
Range on Protein: 3-95
Range on HMM: 59-150/163.0
QDtNIKYCGLPVNDVPGANMKKHFNTAVKFIDEAlEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPI-GPNEGFLKQLW
.|   .|  |...| | |.....|.....||||. ....||||||| || |||.|. .|||| .. .. .||   |...|.|  || || .|| 
ed.lfeYkklkleDspkadislvfeeviefidev.kkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLl
0041856 (Phosphotyrosine protein) phosphatases II 3-96 1.2e-25 85.6 In-house 76-167 (182) alignment 
Range on Protein: 3-96
Range on HMM: 76-167/182.0
QDTNIKYCGLPVNDVPGANmkkhFNTAVKFIDEALEqEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP---IGPNEGFLKQLWL
....|.|. ||. | .  .    ......||.|.|| |.|.||.|| || .|..|...||||...|....|| ..||..||   | || .|. || |
erlgiqylylpwpDhgvpd....ldelldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlal
0036282 (Phosphotyrosine protein) phosphatases II 3-95 1.6e-23 78.7 In-house 66-163 (174) alignment 
Range on Protein: 3-95
Range on HMM: 66-163/174.0
QDTNIKYCGLPVNDVPGANMKKhFNTAVKFIDEALEQ-EDGKVLIHCVAGFSRSATIAIAYLMIRRGM-TAQEATRTVRKKR----PIGPNEGFLKQLW
 ...|.|. ||. |    .. . . ..|||..|||.. ..|.||.|| ||..|..|...||||.|... ....| ..||..|    .. ........| 
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly
0045450 (Phosphotyrosine protein) phosphatases II 3-97 2.1e-21 72.4 In-house 174-299 (307) alignment 
Range on Protein: 3-97
Range on HMM: 174-299/307.0
QDTNIKYCGLPVNDV-----------------PGANMKKHFNTAVKFIDEALE-----QEDGKVLIHCVAGFSRSATIAIAYLMIRRG--------MTAQ
.. ....  |.| |                  |. .  ..|.....||.|...     ...|.||.|| || .|..|...||||.|..        ....
hldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdll

EATRTVRKKRPIGP-NEGFLKQLWLV
|| ...|..|| .  |......|  .
eavkllreqRpgavqnpeqyrflyea
0038934 (Phosphotyrosine protein) phosphatases II 3-95 2.5e-21 71.6 In-house 76-170 (194) alignment 
Range on Protein: 3-95
Range on HMM: 76-170/194.0
QDTNIKYCGLPVND---VPGANMKKHFNTAVKFIDEalEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPIG-PNEGFLKQLW
.. .|.|  ||. |   ||  .. ..|  .|... .  |...|.|..||.||..|..|...|||. |.||.|.|| ...| ||| . || ..|..|.
ekagieylklpfpddgtvPsleillrfldlvdefln..edpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleall
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 3-94 2.9e-20 66.3 In-house 49-140 (148) alignment 
Range on Protein: 3-94
Range on HMM: 49-140/148.0
QDTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALeQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP-IGPNEGFLKQL
..  |.|  ....| |  .... |.....|...|  .| ..||.|.  | |||. .|...|.  . .. .||   |. ||. . || ||||||
dqrgieYlhvaldDkpkedlsaiFediiafvrkak.deGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqL
0040438 (Phosphotyrosine protein) phosphatases II 3-97 4e-19 64.5 In-house 152-271 (317) alignment 
Range on Protein: 3-97
Range on HMM: 152-271/317.0
QDTNIKYCGLPVNDV----------------PGANMKKHFNTAVKFIDEALEQ---EDGKVLIHCVAGFSRSATIAIAYLM-----IRRGMTAQEATRTV
.. .|..  |.| |                 |  .  ..... ..|.... |.   ..|.||.||.|| .|..|...||||      ..|....|| ...
elagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel

RKKRP-IGPNEGFLKQLWLV
|..|| . ........|  .
reqRpgavqtpeqyrflyda
PTPc_DSPc_SM00012 3-72 1.3e-08 30.3 In-house 6-70 (105) alignment 
Range on Protein: 3-72
Range on HMM: 6-70/105.0
QDTNIKYCGLPVNDvpganmkKHFNTAVKFIDEAL----EqeDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQ
. |... .|.| .        ... .... ...      .   . |..|| || .|..|.. ....... .. .
hytgwpdhgvPees.......dsilellravkknknkses..skpvvVhCsaGvgRtgtfvaldillqqleket
PTPc_motif_SM00404 4-95 4.5e-29 96.1 In-house 44-135 (140) alignment 
Range on Protein: 4-95
Range on HMM: 44-135/140.0
DTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEAlEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP-IGPNEGFLKQLW
. ..... .|..|   ... |... ...||..| |.. ||||.|| || |||||..||||| .|.....|| . |...|| | ||..|..|| 
nsgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLi
subfamily_DSP6_pd Subfamily DSP6 4-94 4e-26 85.4 In-house 57-147 (158) alignment 
Range on Protein: 4-94
Range on HMM: 57-147/158.0
DTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQeDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKR-PIGPNEGFLKQL
. ..||  .|..|.  .|. |.|  |..||||| .. . |||.|| || ||| |...|||| .. .. ..|   |.|..  | ||  |..||
sgelkylqipiedhlsqnlakffPeaiefidearsk.kskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgql
0048179 (Phosphotyrosine protein) phosphatases II 4-95 1.3e-25 85.2 In-house 47-138 (144) alignment 
Range on Protein: 4-95
Range on HMM: 47-138/144.0
DTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEqEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP-IGPNEGFLKQLW
...|.|. ||. | .  .. ........||.|||| |.|.||.|| ||..|..|...||||...|....|| . ||..|| . ||.|.|..| 
regiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLl
0049260 (Phosphotyrosine protein) phosphatases II 4-95 4e-24 80.5 In-house 52-143 (152) alignment 
Range on Protein: 4-95
Range on HMM: 52-143/152.0
DTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLMIrRGMTAQEATRTVRKKRP-IGPNEGFLKQLW
.  |.|. ||. | .  ..  ..  ...||........|.||.||.||..|..|...||||. .|....|| . ||.||| . ||.|.|..| 
eqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrfly
0037934 (Phosphotyrosine protein) phosphatases II 4-97 1.2e-20 69.5 In-house 135-237 (243) alignment 
Range on Protein: 4-97
Range on HMM: 135-237/243.0
DTNIKYCGLPVNDVPG--ANMKKHFNTAVKFIDEA----LEQEDGKVLIHCVAGFSRSATIAIAYLMIRR-GMTAQEATRTVRKKRP--IGPNEGFLKQL
.... | . | ..||   ... .... . .||.|.     . ..|.||.||.|| .|..|...||||... |....|| ...|..||  . ........|
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfl

WLV
  .
yea
0040439 (Phosphotyrosine protein) phosphatases II 4-97 2e-20 68.9 In-house 137-241 (249) alignment 
Range on Protein: 4-97
Range on HMM: 137-241/249.0
DTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALE-----QEDGKVLIHCVAGFSRSATIAIAYLM-----IRRGMTAQEATRTVRKKRPIG-PNEGFLK
.. ... .... | |  .  ..|.....||.....      ..|.||.|| || .|..|...||||      ..|....|| ...|..|| . .|.....
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

QLWLV
.|  .
flyea
0042113 (Phosphotyrosine protein) phosphatases II 4-96 9.4e-19 63.2 In-house 138-237 (245) alignment 
Range on Protein: 4-96
Range on HMM: 138-237/245.0
DTNIKYCGLPVNDVPGANMKKHFNTAVKFIDEALE-QEDGKVLIHCVAGFSRSATIAIAYLM-----IRRGMTAQEATRTVRKKRPIGP-NEGFLKQLWL
 ..| |. ||. | . ... ...  ...|...||.  ..|.||.|| || .|..|...||||      ..|....|| . .|..||    .......|  
revihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye
0051429 (Phosphotyrosine protein) phosphatases II 5-118 2.8e-18 62.0 In-house 68-241 (272) alignment 
Range on Protein: 5-118
Range on HMM: 68-241/272.0
TNIKYCGLPVNDVPGANMKKHF------------------------------------------------NTAVKFIDEALEqeDGKVLIHCVAGFSRSA
 .|.|. ||..|     .  ..                                                .. ...... |.  .|.||.|| || .|..
pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTG

TIAIAYLMIrRGMT--------------AQEATRTVRKKR-PIGPNEGFLKQLWLVAVAAASVVASVQTDAVRLLLQ
|.. ..|.. .|..              ..|| . .|..|  ....|.....|. ......  ..||. ....  |.
tvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaald
0043336 (Phosphotyrosine protein) phosphatases II 5-85 8.1e-16 53.7 In-house 176-259 (278) alignment 
Range on Protein: 5-85
Range on HMM: 176-259/278.0
TNIKYCGLPVNDVPGanMKKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLM-----IRRGMTAQEATRTVRKKRPIG
| . | | | ..||     ...   .|...|||| ..|.||.||.|| .|..|....||.      ..|....|| ...|..||  
thyhylgwpdhgvpe..slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpga
PE-PPE PE-PPE domain 5-94 5.2e-06 12.3 Pfam-A 6-99 (225) alignment 
Range on Protein: 5-94
Range on HMM: 6-99/225.0
TNIKYCG--LPVNDVPGANMKKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGM--TAQEATRTVRKKRPIGPNEGFLKQL
. .||    |||.... ..... .. .|. ...|..... .     |.|.|..|..| ...     .   ... .. |    |  || |.|...
vavkypaqflpvtglgsltvdesvaeGvenLnaairaqlaagepvvvfGySqGalvaalekarlaasgdpeaddlsFvlignpnrpnggllarf
subfamily_DSP19_pd Subfamily DSP19 6-95 6.7e-29 95.2 In-house 55-144 (152) alignment 
Range on Protein: 6-95
Range on HMM: 55-144/152.0
NIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQEdGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKR-PIGPNEGFLKQLW
...|. ... |.| ... .....|..||.||.... | ||.|| || ||||...||||| .. .. .|| ..||..| .| |||||.||| 
dftylsieilDlpetdllsylkealdFieearskd.gavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLk
subfamily_DSP12_pd Subfamily DSP12 6-96 1.1e-27 91.3 In-house 48-138 (155) alignment 
Range on Protein: 6-96
Range on HMM: 48-138/155.0
NIKYCGLPVNDVPGANMKKHFNTAVKFIDEALeQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKK-RPIGPNEGFLKQLWL
....  ... | | ... .|...||.||.||| .|.|.||.|| || |||.|| ||||| . ..  ..|...|..| . | ||||||.|| |
kvstkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLkl
subfamily_DSP14_pd Subfamily DSP14 6-95 1.8e-26 86.9 In-house 49-138 (157) alignment 
Range on Protein: 6-95
Range on HMM: 49-138/157.0
NIKYCGLPVNDVPGANMKKHFNTAVKFIDEaLEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP-IGPNEGFLKQLW
.|..  .||.| | |.. |||..... |.| .....||.|.||||| ||||....||||  . .. .|| ..|...|| | || || ||| 
diervkvpveDnpeaklakhfdevadkiee.vkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqli
subfamily_DSP8_pd Subfamily DSP8 6-94 4.1e-23 75.7 In-house 59-147 (159) alignment 
Range on Protein: 6-94
Range on HMM: 59-147/159.0
NIKYCGLPVNDVPGANMKKHFNTAVKFIDEAlEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP-IGPNEGFLKQL
. |.  .||.|    ..   |...|.||| |  .|.|.||.|. || |||||.||||.| .  |. .|| | |..||| | ||  ||.||
eskflrvPvkDkydekllpwfdksvefidka.ksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqL
subfamily_DSP15_pd Subfamily DSP15 6-95 4.5e-23 76.0 In-house 44-133 (151) alignment 
Range on Protein: 6-95
Range on HMM: 44-133/151.0
NIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEqEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPI-GPNEGFLKQLW
.|.|  ....| |.|...|.|. .|.|| ..   ....||.||.|| |||.|...||||    .  ..| ......| .  || || .|| 
dieYkciaasDtpsaklskffkesvefihkcRl.keenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlk
subfamily_MKPLT_pd Subfamily MKPLT 6-94 8.4e-20 64.9 In-house 65-153 (164) alignment 
Range on Protein: 6-94
Range on HMM: 65-153/164.0
NIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQeDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPI-GPNEGFLKQL
 ..|  . |.|..  .. .... | ||. .|..   |.||.||| | |||.....|.|.  .| | .||   ....| |  || ||||||
sveYlqvkvedesdeqlssfleraakfladaids.GGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkql
subfamily_MKPLV_pd Subfamily MKPLV 6-94 8.4e-20 64.9 In-house 65-153 (164) alignment 
Range on Protein: 6-94
Range on HMM: 65-153/164.0
NIKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQeDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPI-GPNEGFLKQL
 ..|  . |.|..  .. .... | ||. .|..   |.||.||| | |||.....|.|.  .| | .||   ....| |  || ||||||
sveYlqvkvedesdeqlssfleraakfladaids.GGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkql
subfamily_STYX_pd Subfamily STYX 6-96 2.1e-19 63.2 In-house 62-152 (166) alignment 
Range on Protein: 6-96
Range on HMM: 62-152/166.0
NIKYCGLPVNDVPGANMKKHFNTAVKFIDEALeQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKR-PIGPNEGFLKQLWL
...|  | | | .  |. ... |  .|||..| |. ||||.|  || ||||.. |||.|   |.  .|| . |...|  | ||||| .||  
rfrylvldvadntveniirylptvkefiddsl.qkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlke
0045098 (Phosphotyrosine protein) phosphatases II 7-97 2.6e-24 81.5 In-house 159-267 (278) alignment 
Range on Protein: 7-97
Range on HMM: 159-267/278.0
IKYCGLPVNDVPGANMKKHFNTAVKFIDEALEQ-------------EDGKVLIHCVAGFSRSATIAIAYLMIRR---GMTAQEATRTVRKKRP--IGPNE
..| . | ..||  .. |.|  ...||.|||..             ..|.||.|| || .|..|...||||...   |....|| ...|..||  . .|.
lhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnl

GFLKQLWLV
.....|  .
eqyrflyef
subfamily_LRR-DSP_pd Subfamily LRR-DSP 7-94 8e-23 74.9 In-house 164-251 (263) alignment 
Range on Protein: 7-94
Range on HMM: 164-251/263.0
IKYCGL-PVNDVPGANMKKHFNTAVKFIDEAleQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP-IGPNEGFLKQL
 ||  .  ..||. |.. .||.    ||.|   .. | ||.|| || |||.|. |.||| .. .. .||   | |||| | || ||..||
fkylsiddiedvdeadisqhfeetnafieeG..rkkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdql
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 7-95 5.8e-22 71.7 In-house 56-146 (154) alignment 
Range on Protein: 7-95
Range on HMM: 56-146/154.0
IKYCGLPVNDVPGANMKKHFNTAVKFIDEAL-EQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP-IGPNEGFLKQLW
|.|. | . | .  .. .... | .|||.|.   |..|||.|. .| ||||...|.||| .. ..  .|   ... |. | ||.|||||| 
ieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqle
0047943 (Phosphotyrosine protein) phosphatases II 7-84 3.4e-14 48.4 In-house 171-253 (273) alignment 
Range on Protein: 7-84
Range on HMM: 171-253/273.0
IKYCGLPVNDVPGanMKKHFNTAVKFIDEALEQ--EDGKVLIHCVAGFSRSATIAIAYLM-----IRRGMTAQEATRTVRKKRPI
. | | | ..||     ... . ......|||.  ..|.|..||.|| .|..|.....|.      ..|... || . .|..|| 
fhytgwpdhgvpp..slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpg
0046845 (Phosphotyrosine protein) phosphatases II 7-84 7.1e-13 44.0 In-house 170-255 (284) alignment 
Range on Protein: 7-84
Range on HMM: 170-255/284.0
IKYCGLPVNDVPGAnmKKHFNTAVKFIDEALE--QEDGKVLIHCVAGFSRSATIAIAYLMIRR--------GMTAQEATRTVRKKRPI
. | . | ..||     ... . .....|.||    .|....|| || .|..|.....|....        |....|| . .|..|| 
fhytswpdhgvpps..pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
subfamily_PTPRK_pd Subfamily PTPRK 7-65 5.3e-06 20.5 In-house 178-234 (314) alignment 
Range on Protein: 7-65
Range on HMM: 178-234/314.0
IKYCGLPVNDVPgaNMKKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLMI
... | |  |||  . .. . . |. ...  |.|.|....||.||  |. |  .   ..
fqflgWpdhdvP..vsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl
0039614 (Phosphotyrosine protein) phosphatases II 8-97 7.4e-18 60.5 In-house 189-284 (297) alignment 
Range on Protein: 8-97
Range on HMM: 189-284/297.0
KYCGLPvnDVPGANMKKHFNTAVKFIDEALEQ--EDGKVLIHCVAGFSRSATIAIAYLM-----IRRGMTAQEATRTVRKKRPIGP-NEGFLKQLWLV
 | | |  |    .  ...  ......|||..  ..|.||.||.|| .|..|...||||      ..|....|| ...|..|| .  .......|  .
qytgwp..dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0051299 (Phosphotyrosine protein) phosphatases II 9-84 8.7e-13 43.8 In-house 189-267 (288) alignment 
Range on Protein: 9-84
Range on HMM: 189-267/288.0
YCGLPVNDVPGanMKKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLM-----IRRGMTAQEATRTVRKKRPI
| . | ..||     ... . ......||.. .| |..|| || .|..|.....|.      ..|... || ...|..|| 
ytnwpdhgvpd..spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpg
subfamily_STYXL1_pd Subfamily STYXL1 10-94 1.9e-17 56.9 In-house 62-146 (157) alignment 
Range on Protein: 10-94
Range on HMM: 62-146/157.0
CGLPVNDVPGANMKKHFNTAVKFIDEALEqEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKR-PIGPNEGFLKQL
  ..|.|.. |.. .... ||.||..  . |.  ||.    | ||||...|||||  . .| ..|   ..| .  . || .|..||
lhiavedeneadllerlkeavqfiekhkk.egevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveql
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 13-95 1e-16 54.4 In-house 53-135 (145) alignment 
Range on Protein: 13-95
Range on HMM: 53-135/145.0
PVNDVPGANMKKHFNTAVKFIDEALEQEDGkVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPI-GPNEGFLKQLW
  .|.   .. .||.    |||   |.  | |..||.|| ||| |...|.||   .||  ||.| || .|    ||  |||.|.
taedlesydlsqhfdevtdfidkgkeegag.vfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknll
0036941 (Phosphotyrosine protein) phosphatases II 15-96 2e-16 55.6 In-house 176-271 (297) alignment 
Range on Protein: 15-96
Range on HMM: 176-271/297.0
NDVPGANMKKHFNTAVKFIDEALE-----QEDGKVLIHCVAGFSRSATIAIAYLM--------IRRGMTAQEATRTVRKKRP-IGPNEGFLKQLWL
 . |  ..  .... ..||.....      ..|.||.||.|| .||.|...|.||        ...|..  || ...|..|| . ........|  
tgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflye
subfamily_RNGTT_pd Subfamily RNGTT 16-93 4.2e-09 30.3 In-house 90-166 (189) alignment 
Range on Protein: 16-93
Range on HMM: 90-166/189.0
DVPGANMKKHFNTAVK-FIDealEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRPIGPNE-GFLKQ
. | |.  |.| . |. |..   .. .  . .||  || |.  ....||. .. . ...| .. .| || |  .  .||.
eaPeaeqvkefiklveeffk...knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylke
Y_phosphatase Protein-tyrosine phosphatase 16-83 1.7e-07 26.3 Pfam-A 142-217 (235) alignment 
Range on Protein: 16-83
Range on HMM: 142-217/235.0
DVPGANMKKHFNTAVKFIDEALEQE---DGKVLIHCVAGFSRSATIAIAYLMIRRGMT-----AQEATRTVRKKRP
. |  ..... .  ...|..  ...   .|.|..|| || .|..|.. . .....  .       .. ...||.||
nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
Y_phosphatase Protein-tyrosine phosphatase 16-83 1.7e-07 26.3 In-house 142-217 (235) alignment 
Range on Protein: 16-83
Range on HMM: 142-217/235.0
DVPGANMKKHFNTAVKFIDEALEQE---DGKVLIHCVAGFSRSATIAIAYLMIRRGMT-----AQEATRTVRKKRP
. |  ..... .  ...|..  ...   .|.|..|| || .|..|.. . .....  .       .. ...||.||
nWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
0048567 (Phosphotyrosine protein) phosphatases II 19-88 6.2e-12 40.1 In-house 52-127 (157) alignment 
Range on Protein: 19-88
Range on HMM: 52-127/157.0
GANMKKHFNTAVKFIDEALEQEDGKVLIHCVAGF---SRSATIAIAYLMIRRGMTAQEATRTVRKKRP---IGPNE
. ..  .|.. .. . . || ..... .|| ||    .|.||.. .||... |.|..|| . .|  ||   ...  
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrda
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 21-77 4e-06 21.2 In-house 172-233 (290) alignment 
Range on Protein: 21-77
Range on HMM: 172-233/290.0
NMKKHFNTAVKFIDEaLEQEDGKVLIHCVAGFSRSATIA---IAYLMIRR---GMTAQEATRT
|....  |... |.  .....  |..||| | ||||..|   ..| .|      .. ...  .
nvqedtktllsliqk.vkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlka
0050432 (Phosphotyrosine protein) phosphatases II 23-83 4.4e-12 41.4 In-house 216-279 (308) alignment 
Range on Protein: 23-83
Range on HMM: 216-279/308.0
KKHFNTAVKFIDEALeqEDGKVLIHCVAGFSRSATIAIAYLM-----IRRGMTAQEATRTVRKKRP
 ... . ...... |  ..|....|| || .|..|.....|.       .|....|| ...|..||
peilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRp
DSPc_SM00195 23-69 6.2e-06 21.1 In-house 177-223 (263) alignment 
Range on Protein: 23-69
Range on HMM: 177-223/263.0
KKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGM
.|..   ......  ....| ...|| || .|..|.. . .....  
tksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskle
PTPc_SM00194 23-69 6.2e-06 21.1 In-house 177-223 (263) alignment 
Range on Protein: 23-69
Range on HMM: 177-223/263.0
KKHFNTAVKFIDEALEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGM
.|..   ......  ....| ...|| || .|..|.. . .....  
tksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskle
subfamily_DSP23_pd Subfamily DSP23 25-83 3.3e-10 34.8 In-house 69-126 (148) alignment 
Range on Protein: 25-83
Range on HMM: 69-126/148.0
HFNTAVKFIDEALEQEDgKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP
  .  |. ..|| |...  | .||. |. |. |.   ||.  |...| ||   ||..||
qvvefvrvveeaeekne.avsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp
subfamily_PRL_pd Subfamily PRL 26-87 1.3e-08 29.1 In-house 74-135 (151) alignment 
Range on Protein: 26-87
Range on HMM: 74-135/151.0
FNTAVKFIDEALEQE-DGKVLIHCVAGFSRsATIAIAYLMIRRGMTAQEATRTVRKKRPIGPN
 .  .. . |. ..| .  | .|||||. | | . .|  .|  ||. ..| . .|.||    |
veeWlellkekfkeepkstvavhcvaGlGr.aPvlvalalieaGmkyedavefirekrrgain
subfamily_PTEN_pd Subfamily PTEN 26-82 2.8e-06 22.4 In-house 98-156 (184) alignment 
Range on Protein: 26-82
Range on HMM: 98-156/184.0
FNTAVKFIDEALEQEDGKV-LIHCVAGFSRSATIAIAYLMIRRGMTAQ-EATRTVRKKR
....|. |.. ||... .|  .|| ||  |. .. .|||. .. .. . ||..   ..|
leeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_MSG5_pd Subfamily MSG5 30-98 4.3e-10 32.9 In-house 89-159 (165) alignment 
Range on Protein: 30-98
Range on HMM: 89-159/165.0
VKFIDEALEQeDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRK-KRPIGPNEGFLKQL--WLVA
 . |  |  .   |.|.||  | ||||.. .||.|   ... ..|   ..     | |. |.. ||  | ||
triihaatsk.rkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweva
subfamily_CDC14_pd Subfamily CDC14 31-92 4.3e-09 30.7 In-house 254-317 (328) alignment 
Range on Protein: 31-92
Range on HMM: 254-317/328.0
KFIdEALEQEDGKVLIHCVAGFSRSATIAIAYLMIRRGMTAQEATRTVRKKRP---IGPNEGFLK
||. |..|. .|.. .|| ||. |  |.  .||| . ..||.||   .|  ||   ||| . ||.
kfl.eiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfle