Gene DSP3-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP017_AA protein Get Run
SpurP017_AA_28-181 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP1_pd Subfamily DSP1 20-179 1.2e-32 107.3 In-house 10-156 (163) alignment 
Range on Protein: 20-179
Range on HMM: 10-156/163.0
GARFLFEPSCdvnEVYERVFVGGEEIARDLSKLATLGITHVLNCAEGPSRMFRVdtnqeyyvdaSIKYCGLPVSDDPRANLKQHFETAAKFIDETlSQKD
  . |..|..   .. . ...|.|. | .|. |..||||..||...  . .|.             .|  |...| |.|.....||.. .||||   .|.
dklklydPve...kildfLylGsetvasnleiLkslgitailnvskeldnvfed..........lfeYkklkleDspkadislvfeeviefidev.kkkn

AKVLIHCVVGFSRSATVAIAYLMIRRGMTAQEATQAVRKNREI-GPNDGFLVQLCELNSEL
 |||||| .| |||.|. .|||| .. .. .|| . |...|.|  || ||  || . ...|
GkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
0041856 (Phosphotyrosine protein) phosphatases II 23-178 2.1e-31 104.3 In-house 11-171 (182) alignment 
Range on Protein: 23-178
Range on HMM: 11-171/182.0
FLFEPSCDVNEVYERVFVGGEEI--------------ARDLSKLATLGITHVLNCAegpsrmfRVDTNQEYYVDASIKYCGLPVSDDPRANlkqhFETAA
. ...| | ... .....|.                 |..|  |  ||||...|..        .  . |.. .. |.|. ||. |..  .    .... 
lpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.......eelywpellerlgiqylylpwpDhgvpd....ldell

KFIDETLSqKDAKVLIHCVVGFSRSATVAIAYLMIRRGMTAQEATQAVRKNRE---IGPNDGFLVQLCELNSE
.||.| |. .. .||.||  | .|..|...||||...|....|| . ||. |    | || .|..||..|   
dfieevle.eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
0051082 (Phosphotyrosine protein) phosphatases II 26-174 3.5e-28 93.5 In-house 3-148 (151) alignment 
Range on Protein: 26-174
Range on HMM: 3-148/151.0
EPSCDVNEVYERVFVGGEEIARDLSKLATLGITHVLNCAEGPSRMfrvdTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQKDAKVLIH
..  . . | ......|   |..|  |..|||....|. . . |     .. ||. ...|... .|. |.|  .| ..|.....|... |..|. .||.|
sdyinfsyvtgglyrsggpladflellkelgiktivnlrseeerg....ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvH

CVVGFSRSATVAIAYLMIrRGMTAQEATQAVRKNRE--IGPNDGFLVQLCE
|  | .|..|....|||. .|....|| . .|. |   . ||..||.||..
CsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_DSP3_pd Subfamily DSP3 27-181 8e-75 243.9 In-house 7-159 (162) alignment 
Range on Protein: 27-181
Range on HMM: 7-159/162.0
PSCDVNEVYERVFVGGEEIARDLSKLATLGITHVLNCAEGpsRMFRVDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQKDAKVLIHC
.|..|.|||....||.|..|.| |||..||||||||.|||  |...|||..|.| |..|||.||.|.| |...|...||||||||||.||||..|||.||
lskevdevypklyvgdeavakdkskLkklGithvlnaaeg..rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhc

VVGFSRSATVAIAYLMIRRGMTAQEATQAVRKNREIGPNDGFLVQLCELNSELHP
|||.|||||...||||||| ||..||...|||.|||.||.||| ||.||..||. 
vvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelkr
subfamily_DSP19_pd Subfamily DSP19 27-178 6e-35 114.8 In-house 8-149 (152) alignment 
Range on Protein: 27-178
Range on HMM: 8-149/152.0
PSCDVNEVYERVFVGGEEIARDLSKLATLGITHVLNCAEGPSRMFRVDtnqeyyvdasIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQKdAKVLIHC
.  .| || .|...|  . | | ..| . .|||.|| | |  ..|  |          ..|. ... |.| ..| .....| .||.|..|..   ||.||
edlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkd..........ftylsieilDlpetdllsylkealdFieearskd.gavlvHC

VVGFSRSATVAIAYLMIRRGMTAQEATQAVRKNR-EIGPNDGFLVQLCELNSE
  | ||||.|.||||| .. .. .|| . ||. |  | ||.||. ||.|...|
nAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeae
0044763 (Phosphotyrosine protein) phosphatases II 28-181 1.2e-40 134.4 In-house 20-172 (178) alignment 
Range on Protein: 28-181
Range on HMM: 20-172/178.0
SCDVNEVYERVFVGGEEIARDLSKLATLGITHVLNCAEGPSRMfRVDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQKDAKVLIHCV
  ...|.......|.   |.||  |  |||||..|..|   .. ......... .|.|.|. .|..|..  .| .||. . .||.| |..|. .||.|| 
yinaseilpglylgslppaddlellkelgithivnlteelelg.flkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

VGFSRSATVAIAYLMIRRGMTAQEATQAVRKNREIGPNDGFLVQLCELNSELHP
 |..||.|...||||...|....|| . ||. | | ||.|.| ||.|. ..|..
aGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllk
0046846 (Phosphotyrosine protein) phosphatases II 28-179 4.1e-29 97.0 In-house 9-172 (176) alignment 
Range on Protein: 28-179
Range on HMM: 9-172/176.0
SCDVNEVYERVFVGGEE----------IARDLSKLATLGITHVLNCAEG-PSRMFRVDTNQEYYVDASIKYCGLPVSDDPRANLkQHFETAAKFIDETLS
  |..........|.            .| .|  |  ||||.|.|. |     ......  ... ...|.|. ||. |    .| ...... .||.| |.
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealk

QKdAKVLIHCVVGFSRSATVAIAYLMIR-RGMTAQEATQAVRKNR--EIGPNDGFLVQLCELNSEL
..  .||.||. | .|..|...|||... .|....|| . ||. |   . ...... .| |   .|
eg.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
PTEN_1 29-181 1.2e-32 108.3 In-house 41-193 (196) alignment 
Range on Protein: 29-181
Range on HMM: 41-193/196.0
CDvnEVYERVFVGGEEIA-RDLSKLATLGITHVLNCAEGPSRmFRVDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQK-DAKVLIHC
..  |. |....| .. . .||  |   |||.|.| .|..    ... . | . .  ..|  .|. |..  .| ..|. ...||.  ||..   .||.||
lq..eideglyrgslkdvaadldnlkedgitlvvnlseeeel.sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHC

VVGFSRSATVAIAYLMIRRGMTAQEATQAVRKNR-EIGPNDGFLVQLCELNSELHP
  | .||.||..|||| ....||.|| . ||. |  ..|| ... .| |  .||. 
kaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
0036282 (Phosphotyrosine protein) phosphatases II 29-177 1.4e-26 88.6 In-house 10-167 (174) alignment 
Range on Protein: 29-177
Range on HMM: 10-167/174.0
CDVNEVYERVFVGGEEIArDLSKLATLGITHVLNCAEGPSRM-----FRVDTNQEYYVDASIKYCGLPVSDDPRANLKQhFETAAKFIDETLSQ-KDAKV
.|.... .|...|.   | ..  |  ||||.|... |   .          ...|....  |.|. ||. |.   .| . .... ||..| ||. .. .|
ldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpv

LIHCVVGFSRSATVAIAYLMIRRGM-TAQEATQAVRKNR----EIGPNDGFLVQLCELNS
|.||  |..|..|...||||.|... ....| . ||. |     . ...... .| ....
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0045098 (Phosphotyrosine protein) phosphatases II 29-178 1e-23 79.6 In-house 20-270 (278) alignment 
Range on Protein: 29-178
Range on HMM: 20-270/278.0
CDVNEVYERVFVGGEE-----------------------------------------IARDLSKLATLGITHVLNCAEGPSR------------------
 ...|... ...|. .                                         .| ..  |  ||||......|   .                  
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

------------------------MFRVDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQ-------------KDAKVLIHCVVGFSR
                         .  ... | .    ..| . |  . |  .. ..|  . .||.| |..             .. .||.||  | .|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SATVAIAYLMIRR---GMTAQEATQAVRKNRE--IGPNDGFLVQLCELNSE
..|...||||...   |....|| . .|. |   . .| .....|.|.  |
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_DSP10_pd Subfamily DSP10 30-180 1.4e-33 110.0 In-house 13-154 (159) alignment 
Range on Protein: 30-180
Range on HMM: 13-154/159.0
DVNEVYERVFVGGEEIARDLSKLATLGITHVLNCAEgpsrmfrvDTNqEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETlSQKDAKVLIHCVVG
.. .|.  .|.| |. |.||. | .|.||.||| .         ..   .. ....||  .||||  . ||||.|| | .||.|   .|...||.||  |
pasqvlpfLflGsekdaadldaldrlnitavlnvtt........svP.nefeeealkYkripvsDtskqnlkqyfeealefieea.rkkgsrvLvhCqaG

FSRSATVAIAYLMIRRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELNSELH
 ||||||.||||| ..... ..| . |...|  | || .|. || |.. ||.
isrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
subfamily_DSP8_pd Subfamily DSP8 30-180 3e-23 76.1 In-house 14-155 (159) alignment 
Range on Protein: 30-180
Range on HMM: 14-155/159.0
DVNEVYERVFVGGEEIARDLSKLATLGITHVLNCAEGPSRMFRVdtnqeyyVDAsiKYCGLPVSDDPRANLKQHFETAAKFIDETLsQKDAKVLIHCVVG
..... . ...| .. . . . |  |||..|||  .   ..  .        ..  |.  .|| |.   .| . |... .||| .  .....||.|.  |
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleel.......kes..kflrvPvkDkydekllpwfdksvefidkak.sengrvlvhvlaG

FSRSATVAIAYLMIRRGMTAQEATQAVRKNR-EIGPNDGFLVQLCELNSELH
 ||||||||||.| .  |. .|| . |.. |  | ||  || || | . ||.
isrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_STYX_pd Subfamily STYX 30-176 4e-20 65.5 In-house 11-154 (166) alignment 
Range on Protein: 30-176
Range on HMM: 11-154/166.0
DVNEVYERVFVGGEEIAR--DLSKLATLGITHVLNCAEGPSRMFrVDTNqeyyVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLsQKDAKVLIHCV
...|.   .|.|    |    | .|   ||||..   . .   . .  |     . ...|  | |.|..  |. ... |  .|||..| ||  |||.|  
emqeilpglflgpysaamksklevlkkhgithivcirqnieanl.ikpn....fpdrfrylvldvadntveniirylptvkefiddsl.qkggkvlvhgn

VGFSRSATVAIAYLMIRRGMTAQEATQAVRKNR-EIGPNDGFLVQLCELN
 | ||||.. |||.|   |.  .|| . |...|  | ||.||  || | .
agisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye
0042113 (Phosphotyrosine protein) phosphatases II 30-174 4.3e-19 64.3 In-house 46-237 (245) alignment 
Range on Protein: 30-174
Range on HMM: 46-237/245.0
DVNEVYERVFVGGEEIARDLS----KLATLGITHVLNCAEGP------------------------------------SRMFRVDTNQEYYVDASIKYCG
|. ..........   . ..      |  ||||..... |                                       | ..|  ......   | |. 
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

LPVSDDPRANLKQHFETAAKFIDETLS-QKDAKVLIHCVVGFSRSATVAIAYLM-----IRRGMTAQEATQAVRKNR-EIGPNDGFLVQLCE
||. |.. ..| .... . .|... |.  .. .||.||  | .|..|...||||      ..|....|| . .|. |  . ........| |
lpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye
PTPc_motif_SM00404 31-176 2.7e-35 116.3 In-house 2-138 (140) alignment 
Range on Protein: 31-176
Range on HMM: 2-138/140.0
VNEVYERVFVGGEEIARDLSKLATLGITHVLNCAEGPSRMfrvdtnqeyYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETlSQKDAKVLIHCVVGF
.... .....|... | .. .|. ||||||.|..|  |           . . ..... .|..|.  ..| .... ...||..   .|  |||.|| .| 
psrilphlylgskskaqnpallkklgithvinvteevslt.........kensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqaGv

SRSATVAIAYLMIRRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELN
|||||..||||| .|.....|| ..|...|. | || .|. ||.|..
SRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_DSP12_pd Subfamily DSP12 31-172 7.1e-31 101.7 In-house 2-136 (155) alignment 
Range on Protein: 31-172
Range on HMM: 2-136/155.0
VNEVYERVFVGGEEIARDLSKLATLGITHVLNCAEGPSrmfrvdtNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLsQKDAKVLIHCVVGF
|... .....|| | . . ..|..|.|||||  .. .        ...      ...  ... |.|.... .|...| .||.|.| ... .||.|| .| 
vsrilpglylggleavqeeellkelkithvlsvikeel.......pehklkkgkvstkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagv

SRSATVAIAYLMIRRGMTAQEATQAVR-KNREIGPNDGFLVQL
|||.|. ||||| . ..  ..|...|. |..|| ||.||| ||
SRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQL
subfamily_DSP15_pd Subfamily DSP15 31-175 5.8e-29 95.1 In-house 2-135 (151) alignment 
Range on Protein: 31-175
Range on HMM: 2-135/151.0
VNEVYERVFVGGEEIARDLSKLATLGITHVLNCAEgpsrmfrvdTNQEYYVDasIKYCGLPVSDDPRANLKQHFETAAKFIDETLSqKDAKVLIHCVVGF
...| . ...|. . ..|  .|    |||.|.  .          ....  |  |.|  ...|| | |.|...|. . .|| .. . |. .||.||..| 
iskvlpglylgnfrdskdeelLkeknithilsvhd.........nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRl.keenvlvhClaGv

SRSATVAIAYLMIRRGMTAQEATQAVRKNREI-GPNDGFLVQLCEL
|||.|...||||    .  ..| ......| .  || ||  || | 
sRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkey
subfamily_DSP14_pd Subfamily DSP14 31-180 1.6e-28 93.6 In-house 7-145 (157) alignment 
Range on Protein: 31-180
Range on HMM: 7-145/157.0
VNEVYERVFVGgEEIARDLSKLATLGITHVLNCAEgpsrmfrvDTNQEYYvdASIKYCGLPVSDDPRANLKQHFETAAKFIDEtLSQKDAKVLIHCVVGF
.... .  |..    |.. ..|.  .||...|..         ..... .   .|..  .||.|.|.|.| .||...|. |.| ...|. |.|.||| | 
lsqitpsLfls.gvaalskellkkkkitliinvtv........elpntkl..kdiervkvpveDnpeaklakhfdevadkiee.vkkkggktlvhCvaGv

SRSATVAIAYLMIRRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELNSELH
||||....||||  . .. .|| ..|.. |  | || ||  || .. ..|.
SRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklk
0037934 (Phosphotyrosine protein) phosphatases II 31-175 6.8e-21 70.4 In-house 39-237 (243) alignment 
Range on Protein: 31-175
Range on HMM: 39-237/243.0
VNEVYERVFVGGE--------EIARDLSKLATLGITHVLNCAEGP----------------------------------SRMFRVDTNQ-EYYVDASIKY
  .|..|.....           | ..  |  ||||..... |                                     |....   . ....   |.|
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

CGLPVSD----DPRANLKQHFETAAKFIDET----LSQKDAKVLIHCVVGFSRSATVAIAYLMIRR-GMTAQEATQAVRKNRE--IGPNDGFLVQLCEL
. ||. |    |  ..| .... . .||.|.       .. .||.||. | .|..|...||||... |....|| . .|. |   . .. .....| |.
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0048076 (Phosphotyrosine protein) phosphatases II 32-179 1.3e-32 107.8 In-house 5-142 (145) alignment 
Range on Protein: 32-179
Range on HMM: 5-142/145.0
NEVYERVFVGGEEIARDLSKLATLGITHVLNCaegpsrmfrvDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQKdAKVLIHCVVGFS
.|.......|.   |.||  |. ||||.|||.           ...|....  |.|. ||. | .  .| ...... .||.| |...  .||.||  | .
seilpglylgslptaldlellkdlgittvlnl..........tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvg

RSATVAIAYLMIRRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELNSEL
|..|...||||...|....|| . ||. |  . ||.|.| .|.|.  ||
Rtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 32-177 1.6e-31 104.4 In-house 5-142 (144) alignment 
Range on Protein: 32-177
Range on HMM: 5-142/144.0
NEVYERVFVGGEEIARDLSKLATLGITHVLNCAEGPsrmfrvdtNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSqKDAKVLIHCVVGFS
.|.......|.   |.||  |. ||||.|.|..|.          .|.. .  |.|. ||. | .  .| ...... .||.| |. .. .||.||  |..
seilpglylgslptaldlellkklgittvinlteey........epefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvg

RSATVAIAYLMIRRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELNS
|..|...||||...|....|| . ||. |  . ||.|.| .|.|...
RtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 32-179 1e-26 87.6 In-house 121-258 (263) alignment 
Range on Protein: 32-179
Range on HMM: 121-258/263.0
NEVYERVFVGGEEIARDLSKLATLGITHVLNCaegpsrmfrVDTNQEYYVDaSIKYCGL-PVSDDPRANLKQHFETAAKFIDETlsQKDAKVLIHCVVGF
.|. ...|.|| . | . | | .||.||.| .         |   . .. .   ||  .  . | ..|.. ||||    ||.|   .|   ||.||  | 
deiidklflGgldsannksilkdlgvthilla.........vadfePlfPk.lfkylsiddiedvdeadisqhfeetnafieeG..rkkGGvlvhcraGv

SRSATVAIAYLMIRRGMTAQEATQAVRKNR-EIGPNDGFLVQLCELNSEL
|||.|. |.||| .. .. .||   | |.| .| || ||. ||   . .|
srsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
subfamily_Slingshot_pd Subfamily Slingshot 32-175 2e-26 86.4 In-house 20-153 (169) alignment 
Range on Protein: 32-175
Range on HMM: 20-153/169.0
NEVYERVFVGGEEIARDLSKLATLGITHVLNCAEgpsrmfRVDtnqEyYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETlSQKDAKVLIHCVVGFS
 .... |..| |  | .| .|   |....|| ..       .|   . . . ...|. . | |.....| ...... |||...  .|..|||.|| .| |
skifdhvylGsewnasnleelkengveyilnvtk......eid...n.ffpekfeylnirvydeeetdllkywnetykfieka.kkkgskvlvhckmGvs

RSATVAIAYLMIRRGMTAQEATQAVRKNREI-GPNDGFLVQLCEL
|||.. ||| | . |.. .|| . |...|..  ||.||| || | 
rsastviayamkeyglsleealeyvkerrsvikPnkgflkqleey
subfamily_DSP6_pd Subfamily DSP6 33-180 3.7e-30 98.5 In-house 16-155 (158) alignment 
Range on Protein: 33-180
Range on HMM: 16-155/158.0
EVYERVFVGGEEIARDLSKLATLGITHVLNCAEgpsrmfrvDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSqKDAKVLIHCVVGFSR
|. .....| .. | .|  |. |.| .||| ..        . .. .  . ..||  .|..|   .|| ..|  | .||||. | |..|||.||  | ||
eilpllylGsakdasnlevlkklkikyvlnvts........nlpnkfeesgelkylqipiedhlsqnlakffPeaiefidears.kkskvlvhClaGisr

SATVAIAYLMIRRGMTAQEATQAVR-KNREIGPNDGFLVQLCELNSELH
| ||..|||| .. .. ..| . |. .. .| ||  |. || . ...|.
svtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
0049260 (Phosphotyrosine protein) phosphatases II 36-177 3.7e-25 83.8 In-house 13-147 (152) alignment 
Range on Protein: 36-177
Range on HMM: 13-147/152.0
ERVFVGGEEIARDLSKLATLGITHVLNCAEGPSrmfrvdtNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQKDAKVLIHCVVGFSRSAT
   ..|.. .| ..  | .||||..... |          . .....  |.|. ||. |..  .| |... . .||.. . .|. .||.||. |..|..|
atqgpgpntladfwrmlkelgittivmltelle.......lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

VAIAYLMIrRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELNS
...||||. .|....|| . ||. |  . || |.| .| | ..
lvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
0043147 (Phosphotyrosine protein) phosphatases II 37-179 2.5e-28 94.4 In-house 25-160 (172) alignment 
Range on Protein: 37-179
Range on HMM: 25-160/172.0
RVFVGGEEIARDLSKLATLGITHVLNCAEGpsrmfrvDTNQEYYVDASIKYCGLPVSDDPRAnLKQHFETAAKFIDE-TLSQKDAKVLIHCVVGFSRSAT
  ..... .| ..  | .|||||..|. |         .. |....  |.|. ||. | .   | .... . .||||  . ... .||.||. |..|..|
tqgplrntladfwrmlkelgithivnltel.......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

VAIAYLMIrRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELNSEL
...||||. .|....|| . ||. |  . .|.... .|..... |
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 37-179 3.3e-20 65.7 In-house 5-141 (145) alignment 
Range on Protein: 37-179
Range on HMM: 5-141/145.0
RVFVGGEEIARDLSKLATLGITHVLNCAEGPSrMfrvdTNQEYYVDaSIKYCGLPVSDDPRANLKQHFETAAKFIDETlSQKDAKVLIHCVVGFSRSATV
|..||    |.|.. |  |||. ..| | | . .    . || . . ||.   .  .|    .| |||.  . |||    .. | |..||. | ||| ||
rlyvgsalhandvptlqelgisrivnmaagsl.v....asqelkse.sieillitaedlesydlsqhfdevtdfidkg.keegagvfvhcmagvsrsvtv

AIAYLMIRRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELNSEL
..|.||   .||  ||.. || ||    ||  || .| .|. .|
svaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekql
subfamily_STYXL1_pd Subfamily STYXL1 37-177 4.9e-19 62.1 In-house 18-151 (157) alignment 
Range on Protein: 37-177
Range on HMM: 18-151/157.0
RVFVGGEEIARDLSKLATLGITHVLNCAEGPSRMFRVDTNqeyyvdaSIKYCGLPVSDDPRANLKQHFETAAKFIDETLSqKDAKVLIHCVVGFSRSATV
....| .. | . .    | .  ..| .    ...  ...         |   ..|.|...|.| .... | .||..    ..  ||.    | ||||.|
klylGnykqaqnpaikkdlkvkahvnvsmdadkliagvad.......vakllhiavedeneadllerlkeavqfiekhkk.egevvlvfsnkGisrsaav

AIAYLMIRRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELNS
.|||||  . .| ..| . ..| .| . || .|. || | . 
iiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWek
DSPc Dual specificity phosphatase, catalytic domain 38-176 2.1e-33 110.0 Pfam-A 1-131 (133) alignment 
Range on Protein: 38-176
Range on HMM: 1-131/133.0
VFVGGEEIARdLSKLATLGITHVLNCAEGPS-RmfrvdtnqEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDeTLSQKDAKVLIHCVVGFSRSATV
...|... |  |..|. ||||.|.|...  . .          . . .|.| ..|| |.  ... ...| | .||. .. ||  |||.||  | |||||.
lylgskstas.lalleklgitlvinvtkevpnn........naikkseieylripvedetetkiskeleeavefie.kaeqkgkkvlVHCqaGisRSatl

AIAYLMIRRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELN
.||||| .......|| ..|...|. | ||.||| ||.|..
iiaYlmktknlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 38-176 2.1e-33 110.0 In-house 1-131 (133) alignment 
Range on Protein: 38-176
Range on HMM: 1-131/133.0
VFVGGEEIARdLSKLATLGITHVLNCAEGPS-RmfrvdtnqEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDeTLSQKDAKVLIHCVVGFSRSATV
...|... |  |..|. ||||.|.|...  . .          . . .|.| ..|| |.  ... ...| | .||. .. ||  |||.||  | |||||.
lylgskstas.lalleklgitlvinvtkevpnn........naikkseieylripvedetetkiskeleeavefie.kaeqkgkkvlVHCqaGisRSatl

AIAYLMIRRGMTAQEATQAVRKNRE-IGPNDGFLVQLCELN
.||||| .......|| ..|...|. | ||.||| ||.|..
iiaYlmktknlslneAyefvkerrskispnagflrqLleye
0049772 (Phosphotyrosine protein) phosphatases II 38-178 9.8e-32 106.3 In-house 155-272 (314) alignment 
Range on Protein: 38-178
Range on HMM: 155-272/314.0
VfvgGEEIARDLSKLAtlgithvlncaegpsrmfRVDTNQEYYVDASIKYCGLPVSDdPRANLKQHFETAAKFIDETlsQKDAKVLIHCVVGFSRSAT-V
    .|  |.||  |                   .. ...|.. .. |||. .||.| . |.| ..|. . .||.|   .|. .||.||  | .|..| |
g...neptaadlellk..................eelydpelferlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfv

AIAYLMIRRGMTAQEATQAVRKNREIGPNDGFLVQLCELNSE
..||||...|....|| . ||. | |.||.||. ||...  .
vaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefi
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 38-176 7.5e-30 97.4 In-house 15-144 (148) alignment 
Range on Protein: 38-176
Range on HMM: 15-144/148.0
VFVGGEEIARDLSKLATLGITHVLNCAEGPSRMFRVDtnqeyyvdaSIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQkDAKVLIHCVVGFSRSATVA
.|.|  . | ||..|. ||.|.. |...    .. .          .|.|  ....|.|. .|.. ||....|.... ..   .||.|. .| |||. .|
LFlGskksaadlealkalgvtrivnatkerdnaldqr.........gieYlhvaldDkpkedlsaiFediiafvrkakde.GrrvLvhlqmGvsrssala

IAYLMIRRGMTAQEATQAVRKN-REIGPNDGFLVQLCELN
...|.  . .. .|| ..|. . | . || ||| || ||.
llwlidfkrvslkealalvkskrryvdpnlgfLkqLaele
subfamily_MKPLT_pd Subfamily MKPLT 41-175 2.3e-21 70.0 In-house 32-156 (164) alignment 
Range on Protein: 41-175
Range on HMM: 32-156/164.0
GGEEIARDLSKLATLGITHVLNCAEGPSRMFrvdtnqeyyvDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQkDAKVLIHCVVGFSRSATVAIAY
|  . |..   |  | |||..| ...    |            |..|  . |.| .  .| ...| ||||. ...     .||.||| | |||..|..|.
Gnakhatnekvlkdlkithivnvsqekkdaf..........pksveYlqvkvedesdeqlssfleraakfladaids.GGrvlvhcvqGksrsssvtvaf

LMIRRGMTAQEATQAVRKNREI-GPNDGFLVQLCEL
|.  .| | .|| . ... | |  || |||.||.. 
LikskgwtlkeayeylkerrsivapnrGflkqlakf
subfamily_MKPLV_pd Subfamily MKPLV 41-175 2.3e-21 70.0 In-house 32-156 (164) alignment 
Range on Protein: 41-175
Range on HMM: 32-156/164.0
GGEEIARDLSKLATLGITHVLNCAEGPSRMFrvdtnqeyyvDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQkDAKVLIHCVVGFSRSATVAIAY
|  . |..   |  | |||..| ...    |            |..|  . |.| .  .| ...| ||||. ...     .||.||| | |||..|..|.
Gnakhatnekvlkdlkithivnvsqekkdaf..........pksveYlqvkvedesdeqlssfleraakfladaids.GGrvlvhcvqGksrsssvtvaf

LMIRRGMTAQEATQAVRKNREI-GPNDGFLVQLCEL
|.  .| | .|| . ... | |  || |||.||.. 
LikskgwtlkeayeylkerrsivapnrGflkqlakf
0040439 (Phosphotyrosine protein) phosphatases II 43-175 1.4e-20 69.4 In-house 65-241 (249) alignment 
Range on Protein: 43-175
Range on HMM: 65-241/249.0
EEIARDLSKLATLGITHVLNCAEGPSR-----------------------MFRVDTNQEY----------YVDASIKYCGLPVSDDPRANLKQHFETAAK
| .. ..  |  ||||..... .   .                       ...|.....|          | . |... .... | |  .. ..||.. .
etvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlld

FIDETLS-----QKDAKVLIHCVVGFSRSATVAIAYLM-----IRRGMTAQEATQAVRKNR-EIGPNDGFLVQLCEL
||.. ..      |. .||.||  | .|..|...||||      ..|....|| . .|. |  . .|......|.|.
fieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
subfamily_CDKN3_pd Subfamily CDKN3 44-160 1.3e-07 25.4 In-house 58-174 (202) alignment 
Range on Protein: 44-160
Range on HMM: 58-174/202.0
EIARDLSKLATLGITHVL-NCAEGPSRMFRVDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKfIDETLsQKDAKVLIHCVVGFSRSATVAIA-YL
.. .|. .| . |.  |.  |. |    .||    . |  | .     |..|    .  .  .   . .  .| ..  | |.||  |. ||. |.    |
svekdieelksqgvedvfvlctrgelskyrvrrlldlyqqaglivhhypiadglvpdiasclkilee.lrinl.kayrktlvhcygglgrsslviaclll

MIRRGMTAQEATQAVRKNR
..   .  ..| . .|. .
ylddtiepkdaidklrdlk
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 44-142 2.4e-07 22.0 Pfam-A 59-156 (168) alignment 
Range on Protein: 44-142
Range on HMM: 59-156/168.0
EIARDLSKLATLGITHVL-NCAEGPSRMFRVDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIdeTLSQKDAKVLIHCVVGFSRSATVAIAYLM
.. .|  .| . ||  |.  |. |    .||    . | .  |     |..|    ..   .|   ..   |  ..  | ||||  |. ||. || . |.
nvqkdteelksygiqdvfvfctrgelskyrvpnlldlyqqygivthhhpiadggtpdiascleimeela..tclknyrktlihcygglgrsclvaaclll
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 44-142 2.4e-07 22.0 In-house 59-156 (168) alignment 
Range on Protein: 44-142
Range on HMM: 59-156/168.0
EIARDLSKLATLGITHVL-NCAEGPSRMFRVDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIdeTLSQKDAKVLIHCVVGFSRSATVAIAYLM
.. .|  .| . ||  |.  |. |    .||    . | .  |     |..|    ..   .|   ..   |  ..  | ||||  |. ||. || . |.
nvqkdteelksygiqdvfvfctrgelskyrvpnlldlyqqygivthhhpiadggtpdiascleimeela..tclknyrktlihcygglgrsclvaaclll
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 46-178 2.1e-26 86.1 In-house 18-151 (154) alignment 
Range on Protein: 46-178
Range on HMM: 18-151/154.0
ARDLSKLATLGITHVLNCAEGPSRMFRvDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETL-SQKDAKVLIHCVVGFSRSATVAIAYLMIR
| .  .|    |...||.. | . .|  | | .      |.|. | . ||.. .. .... | .|||... . .. |||.|.  | ||||...|.||| .
alnkldlqlkniksilnvgiGinnlft.densdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdk

RGMTAQEATQAVRKNRE-IGPNDGFLVQLCELNSE
. ..  .| . ... |  | || ||| ||.  . |
lkislslalellkdsryiikPnqGflkqleifeke
0051429 (Phosphotyrosine protein) phosphatases II 46-175 9.1e-17 57.1 In-house 35-220 (272) alignment 
Range on Protein: 46-175
Range on HMM: 35-220/272.0
ARDLSKLATLGITHVLNCAEGPSRMFrvdtNQEYYVDASIKYCGLPVSDDPRANLKQHF-----------------------------------------
|.|. .|..|||.....  .   | .    .. ... . |.|. ||. ||      ...                                         
aadfwrlkelgiktivdLrseeErgr....lkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdw

-------ETAAKFIDETLSqkDAKVLIHCVVGFSRSATVAIAYLMIrRGMT--------------AQEATQAVRKNR-EIGPNDGFLVQLCEL
       |.  ..... |.  . .||.||  | .|..||. ..|.. .|..              ..|| . .|. |  ..........|.| 
pdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
subfamily_PTPMT1_pd Subfamily PTPMT1 47-162 1.2e-16 55.7 In-house 36-150 (171) alignment 
Range on Protein: 47-162
Range on HMM: 36-150/171.0
RDLSKL-ATLGITHVLNCAEGPSRMFRVDTNQEyYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQKDaKVLIHCVVGFSRSATVAIAYLMIRR
 . ..|     .  |... |     . ... .| .    ...  |.. |   |   .. | . .||... |... .| .||  | .||||....||| ..
slikeLiekenvkavvslneeyelkalanstee.wkklgveqlqlatvDfteapdleklekgvefiekvaskgk.rvYvHCkaGrgRsatlvacylmkke

GMTAQEATQAVRKNREI
 .. .||..|..| |.|
klspeeAlkalkkkRki
0045450 (Phosphotyrosine protein) phosphatases II 52-175 1e-20 70.2 In-house 127-299 (307) alignment 
Range on Protein: 52-175
Range on HMM: 127-299/307.0
LATLGITHVLNCAEGPSR-------------------MFRVDTNQEYYvDASIKYCGLPVSDD-----------------PRANLKQHFETAAKFIDETL
|  .|.|..... |   .                    |.| .  |.. ......  |.|.|                  |  .. ..||.. .||.| .
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

S-----QKDAKVLIHCVVGFSRSATVAIAYLMIRRG--------MTAQEATQAVRKNR-EIGPNDGFLVQLCEL
.     .|. .||.||  | .|..|...||||.|..        ....|| . .|. |  . .| .....|.|.
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 54-175 7.1e-16 54.0 In-house 123-284 (297) alignment 
Range on Protein: 54-175
Range on HMM: 123-284/297.0
TLGITHVLNCAEGPSRMFrVD----------------TNQEYYVDASIK-----------------YCGLPVSDDPRANLKQHFETAAKFIDETLSQ--K
 .|.|....  .   .                     |. ...... ..                 .. ..  |.   .. ...  . ....| |..  |
eqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

DAKVLIHCVVGFSRSATVAIAYLM-----IRRGMTAQEATQAVRKNR-EIGPNDGFLVQLCEL
. .||.||. | .|..|...||||      ..|....|| . .|. |  . ........|...
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0040438 (Phosphotyrosine protein) phosphatases II 56-174 1e-16 56.6 In-house 110-270 (317) alignment 
Range on Protein: 56-174
Range on HMM: 110-270/317.0
GITHVLNCAEGPSR------------------MFRVDTNQEYYvDASIKYCGLPVSDD----------------PRANLKQHFETAAKFIDETLSQ---K
|.|....  |   .                   |.| . .|.. .|.|..  |.|.|.                |  .. .....  .|...  ..   .
gvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedp

DAKVLIHCVVGFSRSATVAIAYLM-----IRRGMTAQEATQAVRKNRE-IGPNDGFLVQLCE
. .||.||. | .|..|...||||      ..|....|| . .|. |  . .. .....|..
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 59-143 2.6e-06 17.8 Pfam-A 321-400 (451) alignment 
Range on Protein: 59-143
Range on HMM: 321-400/451.0
HVLNCAEGPSRMfrvdtnQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQ-KDAKVLIHCVVGFSRSATVAIAYLMI
 |... | ..        ..   ...    .|  |   . .|.........||...||. |. |.|..|  |   |..|..| |  
lvislsekivss......eteekkkkvlelklesskkgskeLrkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailcl
0043336 (Phosphotyrosine protein) phosphatases II 68-171 5.2e-13 44.6 In-house 159-268 (278) alignment 
Range on Protein: 68-171
Range on HMM: 159-268/278.0
SRMFRVDTNQEYYVDASIKYCGLPVSDDPRANLKQHFETAAKFIDETLSQKDAKVLIHCVVGFSRSATVAIAYLM-----IRRGMTAQEATQAVRKNR-E
 | ..|  ... ..     |. |.. |.      ...    |...| |. .. .||.||. | .|..|....||.      ..|....|| . .|. |  
vrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpg

IGPNDGFLVQ
. ... ....
avqtpsqyrf
PTPlike_phytase Inositol hexakisphosphate 72-144 1.9e-06 22.6 Pfam-A 77-149 (149) alignment 
Range on Protein: 72-144
Range on HMM: 77-149/149.0
RV---DTNQEYYVDASIKYCGLPVSDDpRANLKQHFETAAKFIDETlsQKDAKVLIHCVVGFSRSATVAIAYLMIR
.|    ...|  .  ..||. .|..|. .|  .....   ..| ..  ..|. ....|  |  |. |. . . ..|
evteevyeeelaegfgvkYvRipitde.qapeeedvDafvrliksl..prdtalvfnCqaGrgRTTtamviadLlr
PTPlike_phytase Inositol hexakisphosphate 72-144 1.9e-06 22.6 In-house 77-149 (149) alignment 
Range on Protein: 72-144
Range on HMM: 77-149/149.0
RV---DTNQEYYVDASIKYCGLPVSDDpRANLKQHFETAAKFIDETlsQKDAKVLIHCVVGFSRSATVAIAYLMIR
.|    ...|  .  ..||. .|..|. .|  .....   ..| ..  ..|. ....|  |  |. |. . . ..|
evteevyeeelaegfgvkYvRipitde.qapeeedvDafvrliksl..prdtalvfnCqaGrgRTTtamviadLlr
0038934 (Phosphotyrosine protein) phosphatases II 76-175 2.4e-18 61.9 In-house 71-172 (194) alignment 
Range on Protein: 76-175
Range on HMM: 71-172/194.0
NQEYYVDASIKYCGLPVSDD---PR-ANLKQHFETAAKFIDEtlsQKDAKVLIHCVVGFSRSATVAIAYLMIRRGMTAQEATQAVRKNREI-GPNDGFLV
. |.. .| |.|  ||. ||   |  ..|.. .. . .|..|   ... .|..||. |..|..|...|||. |.||.|.|| . .|  |    || ..| 
dpeefekagieylklpfpddgtvPsleillrfldlvdeflne...dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyle

QLCEL
.|.. 
allkr
subfamily_PTPDC1_pd Subfamily PTPDC1 76-161 3e-09 31.6 In-house 74-156 (182) alignment 
Range on Protein: 76-161
Range on HMM: 74-156/182.0
NQEYYVDASIKYCGLPVSDDPRANLKQHFeTAAKFIDETLSQKdaKVLIHCVVGFSRSATVAIAYLMIRRGMTAQEATQAVRKNRE
..| .... | .. .. .|   | |.. . .  | .. .|...  || .||  |  |   .  .||.  . .||..| . ||..| 
dlealmeqgiyvynfgwkDygvasleriL.divkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
subfamily_DSP11_pd Subfamily DSP11 80-160 3.3e-06 21.1 In-house 75-157 (178) alignment 
Range on Protein: 80-160
Range on HMM: 75-157/178.0
YVDASIKYCGLPV--SDDPRANLKQHFETAAKFIDETLSQKDAKVLIHCVVGFSRSATVAIAYLMIRRGMTAQEATQAVRKNR
. | ..||  | .   . |. .| ..|. | |   |.  ..|. . .||  |  |.  .   ||. . |. ...| .|  . |
ltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
0048567 (Phosphotyrosine protein) phosphatases II 81-160 4.2e-09 31.0 In-house 35-118 (157) alignment 
Range on Protein: 81-160
Range on HMM: 35-118/157.0
VDASIKYCGLPVSDDP-RANLKQHFETAAKFIDETLSQKDAKVLIHCVVGF---SRSATVAIAYLMIRRGMTAQEATQAVRKNR
.|. . |  .   . |   ..  .| . .. . . |. .. .. .||  |    .|.||.. .||... |.|..|| . .|  |
iddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
0051299 (Phosphotyrosine protein) phosphatases II 87-160 9.2e-10 33.9 In-house 189-265 (288) alignment 
Range on Protein: 87-160
Range on HMM: 189-265/288.0
YCGLPvsDDPRANLKQHFETAAKFIDETLSQKDAKVLIHCVVGFSRSATVAIAYLM-----IRRGMTAQEATQAVRKNR
| . |  |.   .  ... .  ..... |....  |..||  | .|..|.....|.      ..|... || . .|. |
ytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqR
0047943 (Phosphotyrosine protein) phosphatases II 88-160 1.1e-10 37.0 In-house 174-251 (273) alignment 
Range on Protein: 88-160
Range on HMM: 174-251/273.0
CGLPvsDDPRANLKQHFETAAKFIDETLSQ--KDAKVLIHCVVGFSRSATVAIAYLM-----IRRGMTAQEATQAVRKNR
 | |  |.      ... .  ......|..  .. .|..||. | .|..|.....|.      ..|... || . .|. |
tgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqR
PTPc_DSPc_SM00012 90-149 1.3e-06 23.9 In-house 15-69 (105) alignment 
Range on Protein: 90-149
Range on HMM: 15-69/105.0
LPVSDdpranlkQHFETAAKFIDETLSQK--DAKVLIHCVVGFSRSATVAIAYLMIRRGMTA
.| .        ... .. . ...  ...   . |..||  | .|..|.. ....... .. 
vPees.......dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleke
0036941 (Phosphotyrosine protein) phosphatases II 93-176 1.3e-13 46.4 In-house 176-273 (297) alignment 
Range on Protein: 93-176
Range on HMM: 176-273/297.0
SDDPRANLKQHFETAAKFIDETLS-----QKDAKVLIHCVVGFSRSATVAIAYLM--------IRRGMTAQEATQAVRKNR-EIGPNDGFLVQLCELN
 . |  .. .....  .||.. ..      .. .||.||. | .||.|...|.||        ...|..  || . .|. |  . .. .....|.|. 
tgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal
0046845 (Phosphotyrosine protein) phosphatases II 99-160 1.1e-09 33.6 In-house 186-253 (284) alignment 
Range on Protein: 99-160
Range on HMM: 186-253/284.0
NLKQHFETAAKFIDEtlSQKDAKVLIHCVVGFSRSATVAIAYLMIRR--------GMTAQEATQAVRKNR
.| . .... .....  . .. ....||  | .|..|.....|....        |....|| . .|. |
dlleflrlvrellen..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 101-160 4.7e-06 20.9 In-house 174-238 (290) alignment 
Range on Protein: 101-160
Range on HMM: 174-238/290.0
KQHFETAAKFIDeTLSQKDAKVLIHCVVGFSRSATV---AIAYLMIR---RGMTAQEATQAVRKNR
...  |. . |. .. .... |..||| | ||||..    ..| .|      .. ... .|.||.|
qedtktllsliq.kvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr
0050432 (Phosphotyrosine protein) phosphatases II 102-160 1.1e-08 30.3 In-house 217-278 (308) alignment 
Range on Protein: 102-160
Range on HMM: 217-278/308.0
QHFETAAKFIDETLsqKDAKVLIHCVVGFSRSATVAIAYLM-----IRRGMTAQEATQAVRKNR
... .  ......|  .. ....||  | .|..|.....|.       .|....|| . .|. |
eilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR
subfamily_RNGTT_pd Subfamily RNGTT 104-163 2.2e-08 28.0 In-house 100-157 (189) alignment 
Range on Protein: 104-163
Range on HMM: 100-157/189.0
F-ETAAKFIDetlSQKDAKVLIHCVVGFSRSATVAIAYLMIRRGMTAQEATQAVRKNREIG
| .   .|..    . .  . .||  || |.  ....||. .. . ...| .. .|.|. |
fiklveeffk...knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppG
subfamily_DSP23_pd Subfamily DSP23 107-160 2.5e-08 28.7 In-house 73-125 (148) alignment 
Range on Protein: 107-160
Range on HMM: 73-125/148.0
AAKFIDETlSQKDAKVLIHCVVGFSRSATVAIAYLMIRRGMTAQEATQAVRKNR
  . ..|.  .|.  | .||. |. |. |.   ||.  |...| ||   ||. |
fvrvveea.eekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr
subfamily_MSG5_pd Subfamily MSG5 108-179 3.4e-12 39.8 In-house 89-160 (165) alignment 
Range on Protein: 108-179
Range on HMM: 89-160/165.0
AKFIDETlSQKDAKVLIHCVVGFSRSATVAIAYLMIRRGMTAQEATQAVRK-NREIGPNDGFLVQLCELNSEL
.. |  .   |  |.|.||  | ||||.. .||.|   ... ..| . ..    .| |. |.. || | .  |
triihaa.tskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
subfamily_PRL_pd Subfamily PRL 110-163 1.4e-07 25.7 In-house 80-133 (151) alignment 
Range on Protein: 110-163
Range on HMM: 80-133/151.0
FIDETLSQ-KDAKVLIHCVVGFSRsATVAIAYLMIRRGMTAQEATQAVRKNREIG
 . |. ..  .. | .||| |. | | | .|  .|  ||. ..| . .|..|   
llkekfkeepkstvavhcvaGlGr.aPvlvalalieaGmkyedavefirekrrga