Gene DSP3-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP018_AA protein Get Run
SpurP018_AA_29-183 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0038934 (Phosphotyrosine protein) phosphatases II 22-179 4.1e-20 67.7 In-house 20-176 (194) alignment 
Range on Protein: 22-179
Range on HMM: 20-176/194.0
SIVIALPQRQ-IDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHGRKFFhvdtDQKFYDELKIKFLGLGVSDF----PQSNIKQHFDTAFKFMDEalq
 |....|  . .|......|. . ..  .  .|.  ....|..  .  ...    | . . ...|..| | . |.    ....... .| . .|..|   
fiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryY....dpeefekagieylklpfpddgtvPsleillrfldlvdeflne...

HENGKVLVHCVQGYSRSATIAIAYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNEEL
...|.|.|||. |..|..|...|||. ...|.|..|  ..||||  . || ..|..|.   .||
dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
subfamily_Slingshot_pd Subfamily Slingshot 23-183 3.7e-28 92.0 In-house 10-161 (169) alignment 
Range on Protein: 23-183
Range on HMM: 10-161/169.0
IVIALPQRQIDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHgrkffHVDtdqKFYDElKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEAlQHENGKV
.||     .  ...  ||.| |  | . . ||  |....|| ..      .|   .|..| |...| . | | ..... .......||...| .... ||
lvilgqldsaskifdhvylGsewnasnleelkengveyilnvtk.....eid...nffpe.kfeylnirvydeeetdllkywnetykfieka.kkkgskv

LVHCVQGYSRSATIAIAYLMVSRNMTAQQAATTVREKREI-GPNKGFLQQLCDLNEELHRKK
||||  | ||||.. ||| | . ... ..| . |.|.|..  ||||||.||   .  |. .|
lvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileask
0044763 (Phosphotyrosine protein) phosphatases II 24-183 1.1e-45 150.8 In-house 15-174 (178) alignment 
Range on Protein: 24-183
Range on HMM: 15-174/178.0
VIALPQRQIDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHGRKFFHVDTDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQHENGKVL
. . ..  ..|..|..|.|.  .|.|.. || |||||..|...    .....|.....|  |..| ....|..  .. .||. ...|..|||. ..|.||
lersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvl

VHCVQGYSRSATIAIAYLMVSRNMTAQQAATTVREKREIGPNKGFLQQLCDLNEELHRKK
|||  |..||.|...|||| ........|   |||.| | || |.|.||... ..|. ..
VHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkes
0046846 (Phosphotyrosine protein) phosphatases II 25-180 1.5e-31 104.9 In-house 5-173 (176) alignment 
Range on Protein: 25-180
Range on HMM: 5-173/176.0
IALPQRQIDEVYPNVYVGGES----------SAKDKQRLKTLGITHVLNCAHGRKFFHV--DTDQKFYDELKIKFLGLGVSDFPQSNIkQHFDTAFKFMD
.  ..  .|....|...|.             |.. ..|| ||||.|.|.   . . ..  ... . . .|.|..| |.. |.   .. ........|..
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

EALQHEnGKVLVHCVQGYSRSATIAIAYLMVS-RNMTAQQAATTVREKR--EIGPNKGFLQQLCDLNEELH
|||..  |.|||||. | .|..|...|||. . .......|  .|||.|   . .. .....| .   .|.
ealkeg.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0036941 (Phosphotyrosine protein) phosphatases II 25-183 1.3e-18 62.8 In-house 12-280 (297) alignment 
Range on Protein: 25-183
Range on HMM: 12-280/297.0
IALPQRQIDEVYPNVYVGGESSAKDKQRLK----------------------------------------------------------TLGITHVLNCAH
.|| ... .|..|. . |  | |. .. |.                                                           ...|....   
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlte

GRK--------FFHVD-TDQKFYDELKIKFLGLGV-----------------------------SDFPQSNIKQHFDTAFKFMDEALQH-----ENGKVL
           ... .  . . |.......|.  |                              . |  .. ..... ..|.......     ..|.||
lvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvl

VHCVQGYSRSATIAIAYLM--------VSRNMTAQQAATTVREKR-EIGPNKGFLQQLCDLNEELHRKK
|||. | .||.|...|.||          ....  .|  ..||.|  . .. .....|...  || .||
VHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_DSP3_pd Subfamily DSP3 26-183 3.2e-78 255.0 In-house 5-161 (162) alignment 
Range on Protein: 26-183
Range on HMM: 5-161/162.0
ALPQRQIDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHGrKFFHVDTDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQHENGKVLVH
.|.....|||||..|||.|..||||..||.||||||||.|.| .|..|||...||..|.||.||| |.|.|.......|.||.||.||||....||||||
rllskevdevypklyvgdeavakdkskLkklGithvlnaaeg.rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvh

CVQGYSRSATIAIAYLMVSRNMTAQQAATTVREKREIGPNKGFLQQLCDLNEELHRKK
||.|.|||||...||||..|.||...| .|||.||||.||.|||.||..|.|||.|||
cvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelkrkk
0045098 (Phosphotyrosine protein) phosphatases II 27-182 1.1e-27 92.6 In-house 17-274 (278) alignment 
Range on Protein: 27-182
Range on HMM: 17-274/278.0
LPQRQIDEVYPNVYVGGES-----------------------------------------SAKDKQRLKTLGITHVLNCAHG------------------
|.. ...|..|..|.|. .                                          |.. . |. ||||.......                   
lllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsl

--------------------RKFFHVD-----TDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQH-------------ENGKVLVHCVQG
                    |..  ..     .| . .    ...|.    . | ..| ..|. ...|..|||..             ..|.|||||  |
tygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaG

YSRSATIAIAYLMVSR---NMTAQQAATTVREKRE--IGPNKGFLQQLCDLNEELHRK
 .|..|...|||| ..   ......| ...|..|   . .|......|...  ||...
vgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0041856 (Phosphotyrosine protein) phosphatases II 28-181 2e-33 110.9 In-house 15-174 (182) alignment 
Range on Protein: 28-181
Range on HMM: 15-174/182.0
PQRQIDEVYPNVYVGGESS--------------AKDKQRLKTLGITHVLNCAhgrkffHVDTDQKFYDELKIKFLGLGVSDFPQSNikqhFDTAFKFMDE
. | .|.. .|.|.|.  .              |.. . || ||||...|..       .  . ...  | |..| |.. |..  .    .|....|..|
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd....ldelldfiee

ALQhENGKVLVHCVQGYSRSATIAIAYLMVSRNMTAQQAATTVREKRE---IGPNKGFLQQLCDLNEELHR
.|. |.|.|||||  | .|..|...|||| ........|  .||..|    | || .|. ||. | . |..
vle.eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_DSP19_pd Subfamily DSP19 29-179 2.4e-37 122.6 In-house 9-150 (152) alignment 
Range on Protein: 29-179
Range on HMM: 9-150/152.0
QRQIDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAhgrkffhVDTDQKFYDELKIKFlgLGVSDFPQSNIKQHFDTAFKFMDEALQHEnGKVLVHCVQ
. .. || |..|.|  ..|.||. ||. .|||.|| |       ..... | ......   . . | |. .. .....|..|..||.... | |||||  
dlevgeveprlylgsqdvaadkeilkekkitHilnva.......tgvpnvfpkdftyls..ieilDlpetdllsylkealdFieearskd.gavlvHCnA

GYSRSATIAIAYLMVSRNMTAQQAATTVREKR-EIGPNKGFLQQLCDLNEEL
| ||||...||||| ..... ..| ..|||.|  | ||.||..||.....||
GvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP14_pd Subfamily DSP14 29-183 4.5e-33 108.4 In-house 4-148 (157) alignment 
Range on Protein: 29-183
Range on HMM: 4-148/157.0
QRQIDEVYPNVYVGgESSAKDKQRLKTLGITHVLNCAHgrkffhvDTDQKFYDElkIKFLGLGVSDFPQSNIKQHFDTAFKFMDEaLQHENGKVLVHCVQ
.... .. |. ...  ..|..|. ||  .||...|..        .. .. ...  |. . . |.| |.... .|||.. . ..| .....||.||||| 
laalsqitpsLfls.gvaalskellkkkkitliinvtv.......elpntklkd..iervkvpveDnpeaklakhfdevadkiee.vkkkggktlvhCva

GYSRSATIAIAYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNEELHRKK
| ||||....||||  .... ..| ..|...|  | || || .|| |. ..|. |.
GvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
subfamily_LRR-DSP_pd Subfamily LRR-DSP 29-180 9e-31 100.9 In-house 117-259 (263) alignment 
Range on Protein: 29-180
Range on HMM: 117-259/263.0
QRQIDEVYPNVYVGGESSAKDKQRLKTLGITHV-LNCAHGRKFFhVDTdqkfydelkIKFLGL-GVSDFPQSNIKQHFDTAFKFMDEAlqHENGKVLVHC
    ||. .....||  ||..|  ||.||.||. |  |. . .|  ..          |.| .  . | .. .| |||.    |..|    ..| |||||
ssvPdeiidklflGgldsannksilkdlgvthillavadfePlf.Pkl.........fkylsiddiedvdeadisqhfeetnafieeG..rkkGGvlvhc

VQGYSRSATIAIAYLMVSRNMTAQQAATTVREKR-EIGPNKGFLQQLCDLNEELH
  | |||.|. |.|||  .... ..|   | .|| .| ||.||..||   ...| 
raGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_DSP8_pd Subfamily DSP8 29-182 7.9e-30 97.5 In-house 12-157 (159) alignment 
Range on Protein: 29-182
Range on HMM: 12-157/159.0
QRQIDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHgrkffhVDTDQKFYDELKikFLGLGVSDFPQSNIKQHFDTAFKFMDEAlQHENGKVLVHCVQ
. .. .. .|.|.| .  . ... |. |||..|||  .       . ....  | |  || . | |  . .. . ||....|.| | ..|||.||||.  
dvgptrilknlylGsqkdvlseellsklgisyvlnasn......scpkleelkesk..flrvPvkDkydekllpwfdksvefidka.ksengrvlvhvla

GYSRSATIAIAYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNEELHRK
| |||||.||||.|   .|. ..| . |.|||. | ||  ||.|| . ..||. .
GisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkll
subfamily_STYX_pd Subfamily STYX 29-175 5.3e-24 78.2 In-house 9-153 (166) alignment 
Range on Protein: 29-175
Range on HMM: 9-153/166.0
QRQIDEVYPNVYVGGESSAKDK--QRLKTLGITHVLNCAHGRKFFHVDtdQKFYDelKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQHeNGKVLVHC
.|...|. | ...|  |.|.    . ||  ||||..      .   .    .| |  ....| | |.| .  || ... |  .|.|..||.  |||||| 
rremqeilpglflgpysaamksklevlkkhgithivcirqnieanlik..pnfpd..rfrylvldvadntveniirylptvkefiddslqk.ggkvlvhg

VQGYSRSATIAIAYLMVSRNMTAQQAATTVREKR-EIGPNKGFLQQLCDL
  | ||||.. |||.| .  .  ..| . |.|.|  | ||.|| .|| . 
nagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkey
0049772 (Phosphotyrosine protein) phosphatases II 30-183 4.2e-33 110.8 In-house 155-277 (314) alignment 
Range on Protein: 30-183
Range on HMM: 155-277/314.0
RqidevypnvyvgGESSAKDKQRLKtlgithvlncahgrkffHVDTDQKFYDELKIKFLGLGVSDfPQSNIKQHFDTAFKFMDEAlqHENGKVLVHCVQG
             .| .|.| . ||                  . .|.... .| ||.| . |.| .. .. ..|| ...|..||  ...|.|||||  |
g............neptaadlellk.................eelydpelferlgikylripvpD.gsaplledfdeflefieea..dkggpvlvHCkaG

YSRSAT-IAIAYLMVSRNMTAQQAATTVREKREIGPNKGFLQQLCDLNEELHRKK
 .|..| ...||||  .......|   ||.|| |.||.||..||... ..|....
kgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefileall
PTEN_1 31-182 5.9e-35 115.9 In-house 42-194 (196) alignment 
Range on Protein: 31-182
Range on HMM: 42-194/196.0
QidEVYPNVYVGGESSA-KDKQRLKTLGITHVLNCAHGRKFFHVDTDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQHE-NGKVLVHCVQ
|  |. ...|.| .... .|...||  |||.|.| .....   .. | ... . ....| ... |.. ... ..|| . .|.. .|... ...||||| .
q..eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCka

GYSRSATIAIAYLMVSRNMTAQQAATTVREKR-EIGPNKGFLQQLCDLNEELHRK
| .||.|...|||| ....||..|   |||||  ..|| .....|    .||...
GlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
subfamily_DSP10_pd Subfamily DSP10 31-183 8.5e-35 114.0 In-house 13-157 (159) alignment 
Range on Protein: 31-183
Range on HMM: 13-157/159.0
QIDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHgrkffhvDTDQKFYDeLKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEAlQHENGKVLVHCVQGY
.. .|.| ...| |  |.|.. |..|.||.||| .        .. ..|..  ..|.  . |||  . |.||.|. |..|..|| .... .|||||  | 
pasqvlpfLflGsekdaadldaldrlnitavlnvtt.......svPnefee.ealkYkripvsDtskqnlkqyfeealefieea.rkkgsrvLvhCqaGi

SRSATIAIAYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNEELHRKK
|||||..|||||  .|.. ..|   |.|||  | || .|. || ....||...|
srsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk
PTPc_motif_SM00404 32-176 6.8e-36 118.2 In-house 2-138 (140) alignment 
Range on Protein: 32-176
Range on HMM: 2-138/140.0
IDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHGRKFFhvdtdqkfYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEAlQHENGKVLVHCVQGYS
. .. |..|.|..|.|.... || ||||||.|..   .          . . ....| . ..|  .... ...| . .|...| . ..|||||||  |.|
psrilphlylgskskaqnpallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfiena.ekkggkvlVHCqaGvS

RSATIAIAYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLN
||||..||||| .|......|   |.|.|. | || .|..||....
RSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
0048076 (Phosphotyrosine protein) phosphatases II 32-179 5.1e-35 115.6 In-house 4-142 (145) alignment 
Range on Protein: 32-179
Range on HMM: 4-142/145.0
IDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCahgrkffhvDTDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQHEnGKVLVHCVQGYS
..|..|..|.|.  .|.| ..|| ||||.|||.          ...... .| |..| |.. |..  .. ........|..|||... |.|||||  |..
pseilpglylgslptaldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvg

RSATIAIAYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNEEL
|..|...|||| ........|   ||..|  . || |.|..|... .||
Rtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 32-178 7.3e-34 111.9 In-house 4-143 (144) alignment 
Range on Protein: 32-178
Range on HMM: 4-143/144.0
IDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHGRkffhvdtDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQhENGKVLVHCVQGYS
..|..|..|.|.  .|.| ..|| ||||.|.|.....       .. |.    |..| |.. |..  .. ........|..|||. |.|.|||||  |..
pseilpglylgslptaldlellkklgittvinlteey.......epefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvg

RSATIAIAYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNEE
|..|...||||. .......|   ||..|  . || |.|..|......
RtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_DSP12_pd Subfamily DSP12 32-172 1e-33 110.9 In-house 2-136 (155) alignment 
Range on Protein: 32-172
Range on HMM: 2-136/155.0
IDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHGRKfFHVDTDQKFYDelkikFLGLGVSDFPQSNIKQHFDTAFKFMDEALqHENGKVLVHCVQGYS
.... |..|.|| . ......||.|.|||||  .. .  ..  ....  .      . . . | |. .| .|.|.|..|..||| .|.|.|||||  | |
vsrilpglylggleavqeeellkelkithvlsvikeel.pehklkkgkvs.....tkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvS

RSATIAIAYLMVSRNMTAQQAATTVREK-REIGPNKGFLQQL
||.|| ||||| . ..  ..|  .|.|| .|| ||.|||.||
RSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQL
subfamily_DSP15_pd Subfamily DSP15 32-178 2.8e-31 102.6 In-house 2-138 (151) alignment 
Range on Protein: 32-178
Range on HMM: 2-138/151.0
IDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHgrkffhvdTDQKFYDElkIKFLGLGVSDFPQSNIKQHFDTAFKFMDEAlQHENGKVLVHCVQGYS
|..| |..|.|.   .||...||   |||.|.             .|. ..  |... . .|| |. .....|. . .|. .. . ....|||||. | |
iskvlpglylgnfrdskdeelLkeknithilsvhd........nakkllkd..ieYkciaasDtpsaklskffkesvefihkc.RlkeenvlvhClaGvs

RSATIAIAYLMVSRNMTAQQAATTVREKREI-GPNKGFLQQLCDLNEE
||.|...||||   ..  ..| ......| .  || || .|| . .. 
RsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
0043147 (Phosphotyrosine protein) phosphatases II 32-181 3.2e-30 100.5 In-house 19-162 (172) alignment 
Range on Protein: 32-181
Range on HMM: 19-162/172.0
IDEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAhGRkffhvDTDQKFYDELKIKFLGLGVSDFPQSnIKQHFDTAFKFMDE-ALQHENGKVLVHCVQGY
.|.. .. .....  |.. . ||.|||||..|.  ..      .| ... .| |..| |.. |..   . .... ...|.|| ... ..|.|||||. | 
pdrfiatqgplrntladfwrmlkelgithivnlt.el.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGv

SRSATIAIAYLMVsRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNEELHR
.|..|...||||  .......|  .|||||  . .|......|..... |..
gRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekllll
subfamily_PTPMT1_pd Subfamily PTPMT1 32-162 3.1e-19 64.0 In-house 20-150 (171) alignment 
Range on Protein: 32-162
Range on HMM: 20-150/171.0
IDEVYPNVYVGGESSAKDKQRL-KTLGITHVLNCAHGRKFFHVDTDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQhENGKVLVHCVQGY
.| .  .|..|     .....| .   .  |... .  .. ..   .. . .| ...| | . || ..   ..   . .|...  . .  .| |||  | 
ydriDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvas.kgkrvYvHCkaGr

SRSATIAIAYLMVSRNMTAQQAATTVREKREI
.||||....||| ..... ..| .....||.|
gRsatlvacylmkkeklspeeAlkalkkkRki
subfamily_DSP1_pd Subfamily DSP1 33-183 2e-34 113.0 In-house 19-160 (163) alignment 
Range on Protein: 33-183
Range on HMM: 19-160/163.0
DEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHgrkffhvDTDQKFYDelKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEAlQHENGKVLVHCVQGYSR
 .. . .|.|.|..| ... ||.||||..||...       ..|. | |    ..  | ..| |. .|...|... .|.||. ...|||||.|| .| ||
ekildfLylGsetvasnleiLkslgitailnvsk.......eldnvfed..lfeYkklkleDspkadislvfeeviefidev.kkknGkvlihCqaGisR

SATIAIAYLMVSRNMTAQQAATTVREKREI-GPNKGFLQQLCDLNEELHRKK
|.|. .|||| ..... ..| . |...|.|  || || .|| . ...| ...
sstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklllel
0051082 (Phosphotyrosine protein) phosphatases II 33-175 1.1e-27 91.8 In-house 9-149 (151) alignment 
Range on Protein: 33-175
Range on HMM: 9-149/151.0
DEVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHGRKFFhvdTDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQHENGKVLVHCVQGYSR
  | ...|..|  .| . . ||.|||....|.          .. ... || |..| . . |.|  .. ..||.. .|....|...||.|||||  | .|
syvtgglyrsggpladflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgR

SATIAIAYLMVsRNMTAQQAATTVREKRE--IGPNKGFLQQLCDL
..|....|||  .......|   .|.||   . || .|| ||..|
TGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0036282 (Phosphotyrosine protein) phosphatases II 33-177 4.7e-26 86.9 In-house 13-167 (174) alignment 
Range on Protein: 33-177
Range on HMM: 13-167/174.0
DEVYPNVYVGGESSAkDKQRLKTLGITHVLNCAHGRKFFHV------DTDQKFYDELKIKFLGLGVSDFPQSNIKQhFDTAFKFMDEALQH-ENGKVLVH
 .. |....|.   | . . || ||||.|... . .   ..       ...... .| |..| |.. |.   .. . .....||..|||.. ..|.||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CVQGYSRSATIAIAYLMVSRNM-TAQQAATTVREKR----EIGPNKGFLQQLCDLNE
|  | .|..|...||||  . . ....|  .|||.|     . .. .....| ... 
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0042113 (Phosphotyrosine protein) phosphatases II 33-174 5.1e-20 67.4 In-house 48-237 (245) alignment 
Range on Protein: 33-174
Range on HMM: 48-237/245.0
DEVYPNVYVGGESSAKDKQ----RLKTLGITHVLNCAHGRKF-------------------------------------FHVDTDQKFYDELKIKFLGLG
....|......  .... .     |. ||||.....     .                                     ..|  .....    | .. |.
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

VSDFPQSNIKQHFDTAFKFMDEALQ-HENGKVLVHCVQGYSRSATIAIAYLM-----VSRNMTAQQAATTVREKR-EIGPNKGFLQQLCD
. |..  .. .... ...|...||. ..||.|||||  | .|..|...||||       .......|   .|..|  . .. .....| .
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye
subfamily_DSP6_pd Subfamily DSP6 34-181 1.6e-32 106.2 In-house 16-156 (158) alignment 
Range on Protein: 34-181
Range on HMM: 16-156/158.0
EVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHgrkffhvDTDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQHeNGKVLVHCVQGYSRS
|. |..|.| . .|.. . || |.| .||| ..       . ..|| .. ..|.| . ..|  . |. ..|  |..|.||| .. . ||||||  | |||
eilpllylGsakdasnlevlkklkikyvlnvts.......nlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearsk.kskvlvhClaGisrs

ATIAIAYLMVSRNMTAQQAATTVREKR-EIGPNKGFLQQLCDLNEELHR
 |...|||| ..... ..|   |.... .| ||  |..|| | ...|. 
vtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
0049260 (Phosphotyrosine protein) phosphatases II 34-177 2.1e-27 91.1 In-house 10-147 (152) alignment 
Range on Protein: 34-177
Range on HMM: 10-147/152.0
EVYPNVYVGGESSAKDKQRLKTLGITHVLNCAHGRKFFHVDTDQKFydelkiKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQHENGKVLVHCVQGYSRS
|. .. ..|... |.... ||.||||.....     . .. ..| .      ..| | . |..  .. |... ...|.........|.|||||. | .|.
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi......qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRt

ATIAIAYLMVsRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNE
.|...||||  .......|   |||||  . ||.|.|..| . ..
gtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_STYXL1_pd Subfamily STYXL1 34-180 2.5e-22 72.8 In-house 13-154 (157) alignment 
Range on Protein: 34-180
Range on HMM: 13-154/157.0
EVYP-NVYVGGESSAKDKQRLKTLGITHVLNCAHG-RKFFHVDTDqkfydelKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQhENGKVLVHCVQGYS
|| | ..|.| .. |....  | | .  ..| ..   |... ..|         | | . |.| ..... .... | .|...  . |.  |||   .| |
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvad.......vakllhiavedeneadllerlkeavqfiekhkk.egevvlvfsnkGis

RSATIAIAYLMVSRNMTAQQAATTVREK-REIGPNKGFLQQLCDLNEELH
|||...||||| |...| ..| . ...    . ||..|..|| . ...| 
rsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
0037934 (Phosphotyrosine protein) phosphatases II 34-175 2.2e-21 72.0 In-house 41-237 (243) alignment 
Range on Protein: 34-175
Range on HMM: 41-237/243.0
EVYPNVYVGGE--------SSAKDKQRLKTLGITHVLNCAHGR------------------------------------KFFHVDTDQKFYDELKIKFLG
.|.|......           |.. . |. ||||..... .                                      ..  . .| . .  | |... 
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

LGVSDF----PQSNIKQHFDTAFKFMDEA----LQHENGKVLVHCVQGYSRSATIAIAYLMVSR-NMTAQQAATTVREKRE--IGPNKGFLQQLCDL
|.. |.      ... ...| . .|..|.      ...|.|||||. | .|..|...|||| .. ......|  ..||.|   . .. .....| ..
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 35-178 4.7e-22 74.2 In-house 32-244 (249) alignment 
Range on Protein: 35-178
Range on HMM: 32-244/249.0
VYPNVYVG------------------------GESSAKDKQRLKTLGITHVLNCAHGRKFFHVDTDQKF-------------------------------
..|... .                         |. ... . |. ||||..... .   . ... .| .                               
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---YDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQ-----HENGKVLVHCVQGYSRSATIAIAYLM-----VSRNMTAQQAATTVREKR-EIGPN
   ||  ... |.. . |.|  .. ..|.....|......     ...|.|||||  | .|..|...||||       .......|  ..|..|  . .|
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

KGFLQQLCDLNEE
 .....|...  |
peqyrflyealle
0051429 (Phosphotyrosine protein) phosphatases II 35-179 1.8e-18 62.7 In-house 19-224 (272) alignment 
Range on Protein: 35-179
Range on HMM: 19-224/272.0
VYPN-VYVGGES---SAKDKQRLKTLGITHVLNCAHGRKFFHVDTDQKFydeLKIKFLGLGVSDFPQSNIKQHF--------------------------
| |. .| .|     .|.| .|||.|||.....  .     ....|.       |..| | . |.    | ...                          
vkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw...pgirylhlpilddsaptilygalrvtllseellldyilrellltllls

----------------------DTAFKFMDEALQheNGKVLVHCVQGYSRSATIAIAYLMVsRNMT--------------AQQAATTVREKR-EIGPNKG
                      ..  ..... |.  .|.|||||  | .|..|.. ..|.. ....              ...|   .|..|  .... .
agearevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee

FLQQLCDLNEEL
....|..   ||
qylflyeallel
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 37-179 3.4e-32 104.9 In-house 8-152 (154) alignment 
Range on Protein: 37-179
Range on HMM: 8-152/154.0
PNVYVGGESSAKDKQRLKTLGITHVLNCAHGRKFFHVDTDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEAL-QHENGKVLVHCVQGYSRSAT
 ..|..   .| .|  |.   |...||.. | .    | .    | . |..| | . | .. .| ...| ||.|.|.|.   ||.|||||. .| ||||.
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

IAIAYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNEEL
..|.||| .....  .|   ... |  | ||.|||.||.  . ||
llisylmdklkislslalellkdsryiikPnqGflkqleifekel
subfamily_MKPLT_pd Subfamily MKPLT 38-177 2.4e-26 86.2 In-house 28-158 (164) alignment 
Range on Protein: 38-177
Range on HMM: 28-158/164.0
NVYVGGESSAKDKQRLKTLGITHVLNCAHGRKffhvdtdQKFYDelKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQhENGKVLVHCVQGYSRSATIA
..| |  . |.... || | |||..| . ..|       ..|     ...| . |.| ..... .... | ||. .|..   |.|||||||| |||....
tlylGnakhatnekvlkdlkithivnvsqekk.......dafpk..sveYlqvkvedesdeqlssfleraakfladaid.sGGrvlvhcvqGksrsssvt

IAYLMVSRNMTAQQAATTVREKREI-GPNKGFLQQLCDLNE
.|.|. |.  | ..|   ..|.| |  ||.|||.||.  .|
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 38-177 2.4e-26 86.2 In-house 28-158 (164) alignment 
Range on Protein: 38-177
Range on HMM: 28-158/164.0
NVYVGGESSAKDKQRLKTLGITHVLNCAHGRKffhvdtdQKFYDelKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQhENGKVLVHCVQGYSRSATIA
..| |  . |.... || | |||..| . ..|       ..|     ...| . |.| ..... .... | ||. .|..   |.|||||||| |||....
tlylGnakhatnekvlkdlkithivnvsqekk.......dafpk..sveYlqvkvedesdeqlssfleraakfladaid.sGGrvlvhcvqGksrsssvt

IAYLMVSRNMTAQQAATTVREKREI-GPNKGFLQQLCDLNE
.|.|. |.  | ..|   ..|.| |  ||.|||.||.  .|
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
DSPc Dual specificity phosphatase, catalytic domain 39-176 3.6e-35 115.7 Pfam-A 1-131 (133) alignment 
Range on Protein: 39-176
Range on HMM: 1-131/133.0
VYVGGESSAKdKQRLKTLGITHVLNCAHGRKFFhvdtdqKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEAlQHENGKVLVHCVQGYSRSATIAI
.|.|..|.|. .. |. ||||.|.|...  .        ... . .|..|.. | |. ...| .... | .|...| . ...||||||  |.|||||..|
lylgskstas.lalleklgitlvinvtkevpnn......naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatlii

AYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLN
|||| ..|.....|   |.|.|. | || |||.||....
aYlmktknlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 39-176 3.6e-35 115.7 In-house 1-131 (133) alignment 
Range on Protein: 39-176
Range on HMM: 1-131/133.0
VYVGGESSAKdKQRLKTLGITHVLNCAHGRKFFhvdtdqKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEAlQHENGKVLVHCVQGYSRSATIAI
.|.|..|.|. .. |. ||||.|.|...  .        ... . .|..|.. | |. ...| .... | .|...| . ...||||||  |.|||||..|
lylgskstas.lalleklgitlvinvtkevpnn......naikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatlii

AYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLN
|||| ..|.....|   |.|.|. | || |||.||....
aYlmktknlslneAyefvkerrskispnagflrqLleye
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 39-176 1.9e-28 92.8 In-house 15-144 (148) alignment 
Range on Protein: 39-176
Range on HMM: 15-144/148.0
VYVGGESSAKDKQRLKTLGITHVLNCAHGRKFFHVDTdqkfydelKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEAlQHENGKVLVHCVQGYSRSATIAI
...|   || | ..|| ||.|.. |... |.    .          |..| . ..| |. .... |... .|...| . | ..||||.  | |||. .|.
LFlGskksaadlealkalgvtrivnatkerdnaldqr........gieYlhvaldDkpkedlsaiFediiafvrka.kdeGrrvLvhlqmGvsrssalal

AYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLN
..|.  .... ..|.  |..||. . ||.|||.|| .|.
lwlidfkrvslkealalvkskrryvdpnlgfLkqLaele
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 39-183 2.5e-23 75.8 In-house 6-145 (145) alignment 
Range on Protein: 39-183
Range on HMM: 6-145/145.0
VYVGGESSAKDKQRLKTLGITHVLNCAHGRKFfhvdTDQKFYDElKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEAlQHENGKVLVHCVQGYSRSATIAI
.|||    |.|   |. |||. ..| | |       . |. . | .|. | .. .|.   .. ||||    |.|   . |   |.|||. | ||| |...
lyvgsalhandvptlqelgisrivnmaagslv....asqelkse.sieillitaedlesydlsqhfdevtdfidkg.keegagvfvhcmagvsrsvtvsv

AYLMVSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNEELHRKK
|.||   |||  .||  || .|    ||  ||..| .|. .|...|
aflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkeek
0043336 (Phosphotyrosine protein) phosphatases II 43-168 1.4e-14 49.7 In-house 136-265 (278) alignment 
Range on Protein: 43-168
Range on HMM: 136-265/278.0
GESSAKDKQRLKTLGITHvLNCAHGRKFFHVDTDQKFYdELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQHENGKVLVHCVQGYSRSATIAIAYLM
|.|   .. . ..|...| |.  . |..  ...  ...      .  ||. |.      ...    |...|||...||.|||||. | .|..|....||.
ggsltygdftvtllkeeh.lddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyll

-----VSRNMTAQQAATTVREKR-EIGPNKGF
       .......|  ..||.|  . ..  .
leqlekeggvdleeavkelreqRpgavqtpsq
0051299 (Phosphotyrosine protein) phosphatases II 43-160 2.7e-12 42.2 In-house 141-265 (288) alignment 
Range on Protein: 43-160
Range on HMM: 141-265/288.0
GESSAKDKQRLKTLGITHvLNCAHGRKFFHVDTDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQH---ENGKVLVHCVQGYSRSATIAIA
|.|   .. . ..| ... |.    |..  ...|   .|. ...   . . ..|  .. ....  ..|. .. ..    .| |.|||  | .|..|....
ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfial

YLM-----VSRNMTAQQAATTVREKR
.|.       . ... .|  ..||.|
dllleqlekeggvdvleavkrlreqR
subfamily_CDKN3_pd Subfamily CDKN3 47-161 3.2e-06 20.9 In-house 60-175 (202) alignment 
Range on Protein: 47-161
Range on HMM: 60-175/202.0
AKDKQRLKTLGITHVL-NCAHGRK-FFHVdtdQKFYDELKIkfLGLGVSDFPQSN-IKQHFDTAFKFMDEALQ--HENGKVLVHCVQGYSRSATIA-IAY
 || . ||. |.  |.  |. |    . |   ... |. .    || |  .| ..    .  .  |...|     ..  | ||||  |  ||. ..    
ekdieelksqgvedvfvlctrgelskyrv...rrlldlyqq..aglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviacll

LMVSRNMTAQQAATTVREKRE
|...  .  ..|   .|. . 
lylddtiepkdaidklrdlkg
0045450 (Phosphotyrosine protein) phosphatases II 51-176 9e-21 70.3 In-house 125-300 (307) alignment 
Range on Protein: 51-176
Range on HMM: 125-300/307.0
QRLKTLGITHVLNCAHGR--------KFFHVDTDQKFYD-----------ELKIKFLGLGVSDF-----------------PQSNIKQHFDTAFKFMDEA
. |. .|.|..... .          ...  . ... |.           . ... . | |.|                  |  .. ..|.....|..|.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

LQH-----ENGKVLVHCVQGYSRSATIAIAYLMVSRN--------MTAQQAATTVREKR-EIGPNKGFLQQLCDLN
...     ..|.|||||  | .|..|...|||| ..         .....|  ..||.|  . .| .....|... 
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0039614 (Phosphotyrosine protein) phosphatases II 52-177 8e-18 60.4 In-house 120-286 (297) alignment 
Range on Protein: 52-177
Range on HMM: 120-286/297.0
RLKTLGITHVLNCAHGR-------KFFHVDTDqkFYDELKIK----------------------------FLGLGVSDFPQSNIKQHFDTAFKFMDEALQ
 .. .|.|....            ...  ...   |......                            |. .|  |.   .. .... ......|||.
mvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

H--ENGKVLVHCVQGYSRSATIAIAYLM-----VSRNMTAQQAATTVREKR-EIGPNKGFLQQLCDLNE
.  ..|.|||||. | .|..|...||||       .......|  ..||.|  . .. .....|.|.  
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0040438 (Phosphotyrosine protein) phosphatases II 53-182 2e-17 58.9 In-house 106-278 (317) alignment 
Range on Protein: 53-182
Range on HMM: 106-278/317.0
LKTLGITHVLNCAHGRKF-------------------FHVDTDQKFYdELKIKFLGLGVSDF----------------PQSNIKQHFDTAFKFMDEALQH
.. .|.|....  .   .                   |.| . . .. .  |. . | |.|                 |  .. ...|. ..|.... ..
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

---ENGKVLVHCVQGYSRSATIAIAYLM-----VSRNMTAQQAATTVREKRE-IGPNKGFLQQLCDLNEELHRK
   ..|.|||||. | .|..|...||||       .......|  ..||.|  . .. .....|.|.  |....
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 53-161 1.2e-06 18.8 Pfam-A 314-416 (451) alignment 
Range on Protein: 53-161
Range on HMM: 314-416/451.0
LKTLGITHVLNCAHGRKFFhvDTDQKFYdelKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQH-ENGKVLVHCVQGYSRSATIAIAYLMVSRNMTAQQ
 ..  .. |... .       .|..|     |   |.|. | . . ......... .|... |.. .| |.||.| .|   |.....| | .  . . . 
keekevdlvislsekivss..eteekkk...kvlelklesskkgskeLrkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailclyfdeegkl

AAttVREKRE
 .   .|...
kk..seeekk
subfamily_RNGTT_pd Subfamily RNGTT 59-174 1.3e-09 32.0 In-house 56-169 (189) alignment 
Range on Protein: 59-174
Range on HMM: 56-169/189.0
THVLNCAHGRKFFHVDTD-QKFYDELKIKFLGLGVSdfPQSNIKQHFDTA-FKFMDealQHENGKVLVHCVQGYSRSATIAIAYLMVSRNMTAQQAATTV
  |.. .. ..... .   ..     |..  | |..  |...  ..| .   .|..   .. .  . |||  |. |.  ....||.  ... ...| .. 
glvidltntsryYdkeelekegikyvklqcagkgea..Peaeqvkefiklveeffk...knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalF

REKREIGPNK-GFLQQLCD
.. |. |  |  .|..|..
akaRppGiykedylkellr
subfamily_PTPDC1_pd Subfamily PTPDC1 74-161 9.2e-13 43.0 In-house 72-156 (182) alignment 
Range on Protein: 74-161
Range on HMM: 72-156/182.0
DTDQKFYDELKIKFLGLGVSDFPQSNIKQHFDTaFKFMDEALQHEngKVLVHCVQGYSRSATIAIAYLMVSRNMTAQQAATTVREKRE
  |.. . | .| .  .| .|.    ... .|   | .. |||..  || |||  |  |   .  .||. ....||..| ..||.|| 
sYdlealmeqgiyvynfgwkDygvasleriLdi.vkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
DSPc_SM00195 77-146 1.2e-06 23.5 In-house 154-222 (263) alignment 
Range on Protein: 77-146
Range on HMM: 154-222/263.0
QkfydELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQH---ENGKVLVHCVQGYSRSATIAIAYLMVSRN
.    | . |.  . . . |.... .. .  .... .. ..   ..| ..||| .| .|..|.. . ...|. 
k....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskl
PTPc_SM00194 77-146 1.2e-06 23.5 In-house 154-222 (263) alignment 
Range on Protein: 77-146
Range on HMM: 154-222/263.0
QkfydELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEALQH---ENGKVLVHCVQGYSRSATIAIAYLMVSRN
.    | . |.  . . . |.... .. .  .... .. ..   ..| ..||| .| .|..|.. . ...|. 
k....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 79-160 3.1e-07 24.8 In-house 152-238 (290) alignment 
Range on Protein: 79-160
Range on HMM: 152-238/290.0
FYDELKIKFLGLGVSDFPQSNIKQHFDTAFKFMDEaLQHENGKVLVHCVQGYSRSATI---AIAYLMVS---RNMTAQQAATTVREKR
| || . ..    .... ..|....  |. . ..  .. ..  |.||||.| ||||..    ..| ..     ... ...  ..|..|
fddeeeftvtHsllkgWnklnvqedtktllsliqk.vkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr
subfamily_DSP11_pd Subfamily DSP11 83-160 4.6e-06 20.6 In-house 83-157 (178) alignment 
Range on Protein: 83-160
Range on HMM: 83-157/178.0
LKIKFLGlgvSDFPQSNIKQHFDTAFKFMDEALQHENGKVLVHCVQGYSRSATIAIAYLMVSRNMTAQQAATTVREKR
||..  |    ..|.... ..|  | |   |  ....  . ||| .|  |.  .   ||.   .. ...|  .  | |
lklncpG...hevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
subfamily_DSP23_pd Subfamily DSP23 85-160 4e-10 34.5 In-house 52-125 (148) alignment 
Range on Protein: 85-160
Range on HMM: 52-125/148.0
IKFLGLGVSDFPQSNIKQhFDTAFKFMDEAlQHENGKVLVHCVQGYSRSATIAIAYLMVSRNMTAQQAATTVREKR
. .  |.. |.    ..|  .   . ..|| .. |  | |||..|. |. |.   ||.  |...| .| . ||..|
ltlvrlriddyhppaleq.vvefvrvveea.eekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr
subfamily_PTEN_pd Subfamily PTEN 88-159 3.8e-06 22.0 In-house 83-155 (184) alignment 
Range on Protein: 88-159
Range on HMM: 83-155/184.0
LGLGVSDFPQSNIKQhFDTAFKFMDEALQHENGKV-LVHCVQGYSRSATIAIAYLMVSRNMTAQQAATT-VREK
  ....|    ...  .... . ... |.... .|  |||  |  |. .. .|||. |. .. .. |..   |.
avypfdDhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaea
Y_phosphatase Protein-tyrosine phosphatase 89-152 1.2e-07 26.7 Pfam-A 137-208 (235) alignment 
Range on Protein: 89-152
Range on HMM: 137-208/235.0
GLGVSDFPQSNIKQHFDTAFKFMDEALQHE---NGKVLVHCVQGYSRSATIAIAYLMVSRNMT-----AQQA
 | . . |....... .  ......  ...   .|.|.||| .| .|..|.. . .....  .       |.
qlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqi
Y_phosphatase Protein-tyrosine phosphatase 89-152 1.2e-07 26.7 In-house 137-208 (235) alignment 
Range on Protein: 89-152
Range on HMM: 137-208/235.0
GLGVSDFPQSNIKQHFDTAFKFMDEALQHE---NGKVLVHCVQGYSRSATIAIAYLMVSRNMT-----AQQA
 | . . |....... .  ......  ...   .|.|.||| .| .|..|.. . .....  .       |.
qlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqi
0046845 (Phosphotyrosine protein) phosphatases II 90-160 1.7e-11 39.5 In-house 170-253 (284) alignment 
Range on Protein: 90-160
Range on HMM: 170-253/284.0
LGVSDFPQSNIKQHFDT---AFKFMDEALQ--HENGKVLVHCVQGYSRSATIAIAYLMVSR--------NMTAQQAATTVREKR
. . ..|  .. ....     .....|.|.  . .|...|||  | .|..|.....|. ..        ......|   .||.|
fhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR
0047943 (Phosphotyrosine protein) phosphatases II 94-160 1.8e-12 42.7 In-house 175-251 (273) alignment 
Range on Protein: 94-160
Range on HMM: 175-251/273.0
DFPQSNIKQ---HFDTAFKFMDEALQH--ENGKVLVHCVQGYSRSATIAIAYLM-----VSRNMTAQQAATTVREKR
..|  .. .   .. . ......||..  .||.|.|||. | .|..|.....|.       ..... .|   .|..|
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqR
0050432 (Phosphotyrosine protein) phosphatases II 94-160 1.3e-10 36.5 In-house 206-278 (308) alignment 
Range on Protein: 94-160
Range on HMM: 206-278/308.0
DFPQSNIKQHFDTAFKFMDEALQH-ENGKVLVHCVQGYSRSATIAIAYLM-----VSRNMTAQQAATTVREKR
. |  .. ....  ..|.... .. ..|...|||  | .|..|.....|.       .......|  ..||.|
nWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR
PTPc_DSPc_SM00012 96-150 5e-08 28.5 In-house 16-70 (105) alignment 
Range on Protein: 96-150
Range on HMM: 16-70/105.0
PQ--SNIKQHFDTAFKFMDEALQheNGKVLVHCVQGYSRSATIAIAYLMVSRNMTAQ
|.  ..| ....   |.. .. .  .. |.|||  | .|..|.. .......... .
Peesdsilellravkknknkses..skpvvVhCsaGvgRtgtfvaldillqqleket
0048567 (Phosphotyrosine protein) phosphatases II 99-168 2.5e-09 31.7 In-house 54-129 (157) alignment 
Range on Protein: 99-168
Range on HMM: 54-129/157.0
NIKQHFDTAFKFMDEALQHENGKVLVHCVQGY---SRSATIAIAYLMVSRNMTAQQAATTVREKR---EIGPNKGF
.|  .| . .. . . |....... |||  |.   .|.||.. .||.   ..|...|   .|  |    ...  ..
ailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasy
subfamily_MTMR6_pd Subfamily MTMR6 99-170 4.3e-06 18.3 In-house 204-275 (397) alignment 
Range on Protein: 99-170
Range on HMM: 204-275/397.0
NIKQHFDTAFkFMDEALQHENGKVLVHCVQGYSRSA-TIAIAYLMVSRNMTAQQAATTVREKREIGPNKGFLQ
 ||. .|..  |. .|...|.  |||||  |. |.| ....| |.. .   . .    . ||  ..    | .
hikavldasi.fiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfse
subfamily_PRL_pd Subfamily PRL 101-172 3.7e-07 24.3 In-house 71-142 (151) alignment 
Range on Protein: 101-172
Range on HMM: 71-142/151.0
KQHFDTAFKFMDEALQH-ENGKVLVHCVQGYSRSAtIAIAYLMVSRNMTAQQAATTVREKREIGPNKGFLQQL
..  .  .. . |. ..  .  | |||| |  |.  . .|  ..   |. ..|   .||||    |.  |. |
eevveeWlellkekfkeepkstvavhcvaGlGraP.vlvalalieaGmkyedavefirekrrgainskqlkfl
subfamily_CDC14_pd Subfamily CDC14 109-168 3.9e-06 20.9 In-house 253-315 (328) alignment 
Range on Protein: 109-168
Range on HMM: 253-315/328.0
KFMDEALQHENGKVLVHCVQGYSRSATIAIAYLMVSRNMTAQQAATTVREKRE---IGPNKGF
| . |.... .|.. |||  |  |  |.  .|||   ..||..| . .|  |    ||| . |
kkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkf
subfamily_MSG5_pd Subfamily MSG5 116-182 1.4e-10 34.5 In-house 96-163 (165) alignment 
Range on Protein: 116-182
Range on HMM: 96-163/165.0
QHENGKVLVHCVQGYSRSATIAIAYLMVSRNMTAQQAATTVREK-REIGPNKGFLQQLCDLNEELHRK
. .. |.||||  | ||||.. .||.|   |.. ..|   .. .  .| |. |.. || . .  | .|
tskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk