Gene DSP8 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP8
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP020_AA protein Get Run
SpurP020_AA_165-311 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 22-136 2.5e-13 42.5 Pfam-A 3-112 (113) alignment 
Range on Protein: 22-136
Range on HMM: 3-112/113.0
KTLGSALnSQEKLLLVDSRSFLEYNVDHIQHAINITGSKLVKRRLQHNKITIKELLTTACETePDPGSEVVVYDqgtldITCLTADTFLSVLLAK-LNE-
| | . |  .||..|.| ||. ||.  ||. |.|.  . | .|| .  |  ..| | ..     |.  .||||.      ..  . .  ..|||. |.| 
kelkell.ekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkk.ldkdktvvvyc.....rsgnrsggaaalllalilkel

SFKTVSLLAGGYTSFQS
..|.|..| ||......
gyknvyvLdGGfeawka
0042113 (Phosphotyrosine protein) phosphatases II 155-305 4.1e-26 87.3 In-house 22-240 (245) alignment 
Range on Protein: 155-305
Range on HMM: 22-240/245.0
PLSQPCLPVTNTGP------------TRVLGFLYLGSQQDVMSEE----CLKNYGINYVLNVSRSC----------------------------------
. .. .|..... .             |. . ......    . |     |...||........                                    
dhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehldd

-----------PIPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRS--ANGSVIVHCLAGISRSPTVAIAFIM-----RYLNMNVDEAYKYVKEK
           . .| .  .|.|..|. |..   .| .....|||..|...  .|| |.||| ||..|. |...|..|     ..|.....||.|.....
ytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsq

RATISPNFNFLGQLLEYEK
|  . ...... .| |...
Rpgavqtpsqyrflyeall
subfamily_DSP8_pd Subfamily DSP8 156-311 1.1e-78 256.3 In-house 3-158 (159) alignment 
Range on Protein: 156-311
Range on HMM: 3-158/159.0
LSQPCLPVTNTGPTRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCPIPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLA
||||||.|...||||.| .||||||.||.|||.|...||.||||.|.||| .|.|....|.|.||.|.. ||.|||||...|||||..|.||.|.||.||
lsqPCLsvadvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvla

GISRSPTVAIAFIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKIIRTRQ
|||||.|||||.||..|.|..||||..|||||.|||||.||||||||||| .....
GisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkllt
0044763 (Phosphotyrosine protein) phosphatases II 157-308 4.7e-41 135.7 In-house 12-171 (178) alignment 
Range on Protein: 157-308
Range on HMM: 12-171/178.0
SQPCLPVTNTGPTRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCP------IPEFLPQ--THFHRIPVRDNHGEKILPWFDEALEFIDKVR-SANG
 . .. . .......|..|||||. ...  | ||..||....|..  ..      .|... .   ....||. |..   .| .|.|..|||.... . .|
leglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekgg

SVIVHCLAGISRSPTVAIAFIMRYLNMNVDEAYKYVKEKRAtISPNFNFLGQLLEYEKIIR
 |.||| ||..||.|...|..|..|.....||...|.|.|  |.||...| ||.|.|....
pvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
PTEN_1 159-308 1.1e-27 92.1 In-house 36-192 (196) alignment 
Range on Protein: 159-308
Range on HMM: 36-192/196.0
PCLPVTNtgptRVLGFLYLGSQQDV-MSEECLKNYGINYVLNVSRSCPIP--------EFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSAN--G
|..|..     .. ..||.||. || .  . ||  ||  |.|.|  ....        .|  .  ....|..| .   .  .||.. .||. ..|..  .
psrpllq....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngn

SVIVHCLAGISRSPTVAIAFIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKIIR
 |.||| ||..|| ||..|. |.. ....||| ..|.|||  ..||  .. .||||.. ..
vVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0041856 (Phosphotyrosine protein) phosphatases II 161-307 8e-35 115.4 In-house 17-172 (182) alignment 
Range on Protein: 161-307
Range on HMM: 17-172/182.0
LpvtntGPTRVLGFLYLGSQQD--------------VMSEECLKNYGINYVLNVSRSCPIPEFLPQT--HFHRIPVRDNHGEKilpwFDEALEFIDKVRS
.     ......  |||||. .               .  . ||..||....|..  .  ||.|...  .....|. |..       .||.|.||..|..
r.....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevle

ANGSVIVHCLAGISRSPTVAIAFIMRYLNMNVDEAYKYVKEKRA--TISPNFNFLGQLLEYEKII
 .| |.||| ||..|..|...|..|..|.....||.|.|...|    |.||..|. ||...|.. 
eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
0037934 (Phosphotyrosine protein) phosphatases II 162-306 1.7e-28 95.3 In-house 33-240 (243) alignment 
Range on Protein: 162-306
Range on HMM: 33-240/243.0
PVTNTGPTRVLGFLYLGSQ--------QDVMSEECLKNYGINYVLNVSRSC--------------------------------------------PIPEF
   | . ..|.. |.....         .    . |...||...... . .                                            . ...
dyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddlt

LPQTHFHRIPVRD----NHGEKILPWFDEALEFIDK-----VRSANGSVIVHCLAGISRSPTVAIAFIMRYL-NMNVDEAYKYVKEKRAT-ISPNFNFLG
.  .|.|..|. |    .. | .| ..||. |||..     ... .| |.||| ||..|. |...|..| .| .....||.|...|.|   . ...... 
rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyr

QLLEYEKI
.| |... 
flyealle
0046846 (Phosphotyrosine protein) phosphatases II 164-307 4.2e-29 96.9 In-house 8-172 (176) alignment 
Range on Protein: 164-307
Range on HMM: 8-172/176.0
TNTGPTRVLGFLYLGSQQ----------DVMSEECLKNYGINYVLNVSRSC--------PIPEFLP--QTHFHRIPVRDNHGEKIlPWFDEALEFIDKVR
 . ....... |.|||                 | ||..||..|.|.             ... |   . .....|..|..   .  ...|.||||....
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

SANGSVIVHCLAGISRSPTVAIAFIMRY-LNMNVDEAYKYVKEKRA-TISPNFNFLGQLLEYEKII
...| |.||| |||.|..|...|.....  ...|.||...|.|.|   . ...... .| |.|. .
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_DSP10_pd Subfamily DSP10 165-310 5.8e-53 173.0 In-house 11-156 (159) alignment 
Range on Protein: 165-310
Range on HMM: 11-156/159.0
NTGPTRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCPIPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVA
..  ..|| ||.|||..|  ... |....|..||||  |.|      . ...||||.|.. ...   |.||||||...|. . .|.||| |||||| ||.
tapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvv

IAFIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKIIRTR
||..|..||... .|||.|||||..||||.||.|||||.|| ..  
iaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
subfamily_DSP6_pd Subfamily DSP6 165-310 6.5e-48 156.2 In-house 11-157 (158) alignment 
Range on Protein: 165-310
Range on HMM: 11-157/158.0
NTGPTRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCPI-PEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTV
.. | ..| .|||||..|    | ||...|.|||||    |   |  .. .. .||..|.. ...  .| ||.||||. ||.. .|.|||||||||| ||
aefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtv

AIAFIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKIIRTR
..|..|..|.. ...||..||.... |||||||.||||..|. .|..
tlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls
0036282 (Phosphotyrosine protein) phosphatases II 166-307 6.5e-27 89.7 In-house 10-169 (174) alignment 
Range on Protein: 166-307
Range on HMM: 10-169/174.0
TGPTRVLGFLYLGSQQDVmSEECLKNYGINYVLNVSRSCPIP--------------EFLPQTHFHRIPVRDNHGEKILPwFDEALEFIDKVRSA--NGSV
 . ..... |..|.       | ||..||..|... ....                .     .....|. |..   .   ..|...|.....|   .| |
ldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpv

IVHCLAGISRSPTVAIAFIMRYLNM-NVDEAYKYVKEKR---ATISPNFNFLGQLLEYEKII
.||| ||..|..|...|..| .. . ....|...|.|.|     . ...... .| ..||..
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0048179 (Phosphotyrosine protein) phosphatases II 167-306 3.5e-37 122.6 In-house 3-143 (144) alignment 
Range on Protein: 167-306
Range on HMM: 3-143/144.0
GPTRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCPIPEFLPQ-THFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAI
 |...|. |||||. .... | ||..||..|.|.. ... ... .. ......|. |..   .| ...|.||||..... .| |.||| ||..|..|...
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AFIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKI
|..|..|.....||...|...|  . ||...| .||||||.
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 167-307 4.7e-37 122.2 In-house 3-142 (145) alignment 
Range on Protein: 167-307
Range on HMM: 3-142/145.0
GPTRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCPIPEfLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIA
.|...|. |||||. .... | ||..|| .|||... .. .|    ......|. |..   .| ...|.||||.......| |.||| ||..|..|...|
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

FIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKII
..|..|.....||...|...|  . ||...| .|.|.|...
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0043147 (Phosphotyrosine protein) phosphatases II 167-309 9.6e-35 115.2 In-house 18-162 (172) alignment 
Range on Protein: 167-309
Range on HMM: 18-162/172.0
GPTRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRS--CPIPEFLPQTHFHRIPVRDNHGEkILPWFDEALEFIDK--VRSANGSVIVHCLAGISRSPT
 |.|.. ......  . .  . ||..||....|. .    | ...    .....|. |..   .| ...|.|||||.  ..| .| |.||| ||..|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

VAIAFIMRyLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKIIRT
...|..|. |.....||...|.|||  ...|.... .|...||....
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekllll
PTPc_motif_SM00404 168-305 1.5e-45 149.5 In-house 2-139 (140) alignment 
Range on Protein: 168-305
Range on HMM: 2-139/140.0
PTRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCPIPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAF
|.|.|. |||||... .....||..|| .|.||........  .. .. .||..||. .|.....|..|.||..... .|.|.||| ||.||| |..||.
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

IMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEK
.||| .....|||..|||.| .||||.||. ||.||||
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP1_pd Subfamily DSP1 168-307 1.6e-44 145.9 In-house 17-156 (163) alignment 
Range on Protein: 168-307
Range on HMM: 17-156/163.0
PTR-VLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCPiPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIA
|.. .| ||||||...    |.||. ||  .||||....   |    ........|.. . |  .|.|..||||.|...|| |..|| |||||| |. .|
PvekildfLylGsetvasnleiLkslgitailnvskeld.nvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

FIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKII
..|.  .....||...||..|. ||||..| .|||.||| .
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
subfamily_Slingshot_pd Subfamily Slingshot 168-310 1.4e-34 112.9 In-house 19-160 (169) alignment 
Range on Protein: 168-310
Range on HMM: 19-160/169.0
PTRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRScpIPEFLPQT-HFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIA
....  ..||||. .    | ||. |..|.|||..   | .| |.. ....| | |.. ...|....|. .||.|..... .|.|||  |.||| .. ||
askifdhvylGsewnasnleelkengveyilnvtke..idnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

FIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKIIRTR
. |.  .....||..||||.|  | || .|| || ||| |....
yamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileas
0049260 (Phosphotyrosine protein) phosphatases II 168-307 3.3e-31 103.4 In-house 8-149 (152) alignment 
Range on Protein: 168-307
Range on HMM: 8-149/152.0
PTRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCPIPEFLPQT--HFHRIPVRDNHGEKILPWFDEALEFIDK-VRSANGSVIVHCLAGISRSPTVA
|.........|..      . ||..||...... . ......      .....|. |..  ..  .....|.||.|  .. .| |.||| ||..|..|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IAFIMRyLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKII
.|..|. |.....||...|.|||  . ||...| .|.|.||..
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0045098 (Phosphotyrosine protein) phosphatases II 168-306 2.9e-26 87.9 In-house 22-270 (278) alignment 
Range on Protein: 168-306
Range on HMM: 22-270/278.0
PTRVLGFLYLGSQQ-----------------------------------------DVMSEECLKNYGINYVLNVSRS-----------------------
| ... .||||..                                               ..|...||...... .                        
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

----------------------------CPIPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRS--------------ANGSVIVHCLAGISRSP
                               . .. . |.. .|  . . . || .|.|.||||.....               .| |.||| ||..|. 
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

TVAIAFIMRYL---NMNVDEAYKYVKEKRAT-ISPNFNFLGQLLEYEKI
|...|..|..|   .....||.|.....|   . .|.... .| |..  
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_LRR-DSP_pd Subfamily LRR-DSP 168-306 6.3e-26 85.0 In-house 120-257 (263) alignment 
Range on Protein: 168-306
Range on HMM: 120-257/263.0
PTRVLGFLYLGSQQDVMSEECLKNYGINYV-LNVSRSCPipeFLPQT-HFHRI-PVRDNHGEKILPWFDEALEFIDKVRSaNGSVIVHCLAGISRSPTVA
|  ..  |.||...  . .  ||. |. .. | |.   |   . |..  .  |  ..|    .|  .|.|   ||.. |  .| |.||| ||.||| |. 
PdeiidklflGgldsannksilkdlgvthillavadfeP...lfPklfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraGvsrsstlv

IAFIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKI
|...|.. ...  ||.  |..||. | ||  |. ||. ||| 
isylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk
subfamily_DSP12_pd Subfamily DSP12 169-307 7.3e-37 121.1 In-house 3-143 (155) alignment 
Range on Protein: 169-307
Range on HMM: 3-143/155.0
TRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRScPIPEFLPQTHFHR---IPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAI
.|.|. ||||. ..|..|| ||...|. || | .  ..||. ...   .   |...|.  | || ..|||..||.. .. .|.|.||| ||.||| |. |
srilpglylggleavqeeellkelkithvlsvike.elpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

AFIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKII
|..|.. ......|.| ||||. .|.|| .|| ||  .||. 
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
subfamily_DSP14_pd Subfamily DSP14 169-309 3e-36 118.7 In-house 8-146 (157) alignment 
Range on Protein: 169-309
Range on HMM: 8-146/157.0
TRVLGFLYLGsQQDVMSEECLKNYGINYVLNVSRSCPIpEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFI
...   |.|.  . ..|.| ||...|. ..||..  |  . |.. .  ..||.||. .|. ..|||. . |..|. ..| ..||| ||.||| ....|..
sqitpsLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKIIRT
|.| ...  ||||.||..|  |.||  |  || .||| .. 
mkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkg
0049772 (Phosphotyrosine protein) phosphatases II 169-307 3.6e-34 114.3 In-house 155-273 (314) alignment 
Range on Protein: 169-307
Range on HMM: 155-273/314.0
TrvlgflylgSQQDVMSEECLKnyginyvlnvSRSCPIPEFLPQ-THFHRIPVRDnHGEKILPWFDEALEFIDKVrSANGSVIVHCLAGISRSPT-VAIA
.         .. ...  | ||          .. .. . |  .  ...|||| | ... .| .|||.||||... ...| |.||| ||..|..| |..|
g.........neptaadlellk..........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaa

FIMRYLNMNVDEAYKYVKEKRAtISPNFNFLGQLLEYEKII
..|..|.....||...|..||  |.||..|. ||..||.| 
ylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
0051082 (Phosphotyrosine protein) phosphatases II 169-303 1.8e-23 78.2 In-house 9-149 (151) alignment 
Range on Protein: 169-303
Range on HMM: 9-149/151.0
TRVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSC---PIPEFLPQ--THFHRIPVRDNHGEKILPWFDEALEFIDKVRSA-NGSVIVHCLAGISRSPT
..| |.||....      | ||..||....|.         ||.||.   ....||. |..  ..  .||..|||......  || |.||| ||..|. |
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

VAIAFIMRyLNMNVDEAYKYVKEKRA-TISPNFNFLGQLLEY
......|  |.....||......||   . ||  || ||...
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP15_pd Subfamily DSP15 170-306 2.5e-30 99.5 In-house 4-138 (151) alignment 
Range on Protein: 170-306
Range on HMM: 4-138/151.0
RVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCpiPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIM
.||  ||||  .|   || ||.  |  .|.|. .    ..|...... |.. |  . |.  .|.|. ||| | |. ...|.||||||.||| |...|..|
kvlpglylgnfrdskdeelLkeknithilsvhdna..kkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

RYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKI
  ...|  .| . .|..|..  ||| |  || |||| 
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 170-307 3.4e-20 66.0 In-house 5-152 (154) alignment 
Range on Protein: 170-307
Range on HMM: 5-152/154.0
RVLGFLYLGSQQDVMSEECLKNYGINYVLNVSRScpIPEFLPQT----------HFHRIPVRDNHGEKILPWFDEALEFIDKVR--SANGSVIVHCLAGI
..  |||..|..  .    |... |. .|||.    |.. ...           .. .. . |.   .|.  .| |.||||.      |. |.||. .|.
keaiflyissfdaalnkldlqlkniksilnvgiG..innlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGv

SRSPTVAIAFIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKII
||| ...|...|  |.... .|.. .|. |  |.||  || ||  .||  
srsaallisylmdklkislslalellkdsryiikPnqGflkqleifekel
subfamily_DSP19_pd Subfamily DSP19 171-307 1.1e-36 120.4 In-house 15-150 (152) alignment 
Range on Protein: 171-307
Range on HMM: 15-150/152.0
VLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSCPIPeFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMR
|   ||||||. ....| ||. .| ..|||.   |   |  . ..  |.. |.  ...| ...|||.||...||..| |.||| ||.|||..|.||..|.
veprlylgsqdvaadkeilkekkitHilnvatgvpnv.fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

YLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKII
  .... ||...|.|.| .|.||  |. || |||. .
keelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP3_pd Subfamily DSP3 171-307 8.4e-27 87.8 In-house 14-157 (162) alignment 
Range on Protein: 171-307
Range on HMM: 14-157/162.0
VLGFLYLGSQQDVMSEECLKNYGINYVLNVSRSC--PI---PEFLP--QTHFHRIPVRDNHGEKILPWFDEALEFIDKV-RSANGSVIVHCLAGISRSPT
|   ||.| ..  . .. ||. || .||| ...    .   .||    . ... ..|.|.   ..  .|..| .|||.   . .| |.||| .|.|||.|
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

VAIAFIMRYLNMNVDEAYKYVKEKRAtISPNFNFLGQLLEYEKII
...|..| . .|.. || . |..||. | ||  || || |... .
lvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldeel
subfamily_STYXL1_pd Subfamily STYXL1 171-307 2.4e-22 72.8 In-house 14-153 (157) alignment 
Range on Protein: 171-307
Range on HMM: 14-153/157.0
VL-GFLYLGSQQDVMSEECLKNYGINYVLNVSRS-CPIPEFLPQ-THFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAF
|| |.||||  .. ....  |.  .  ..|||    .. . ... ..  .|.| |.   ..|. ..|| .||.| .  .  |.|    ||||| .|.||.
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

IMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKII
.| . ...  .||||.|. .  . || .|. || |.|| .
lmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0051429 (Phosphotyrosine protein) phosphatases II 171-305 8.6e-22 73.5 In-house 20-222 (272) alignment 
Range on Protein: 171-305
Range on HMM: 20-222/272.0
VLGFLYLGSQQ---DVMSEECLKNYGINYVLNVSRSC-----PIPEFLPQTHFHRIPVRDNHGEKILPWF------------------------------
. |.||....    .. . . ||..||...... . .     . . ..|. .....|. |.. . || ..                              
kpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea

------------------DEALEFIDKVRSaNGSVIVHCLAGISRSPTVAIAFIMRyLNMN--------------VDEAYKYVKEKRATISPNFNFLGQL
                  .. ||... ... .| |.||| ||..|. ||. ....  |...              ..||.......|. . ..  .. .|
revmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfl

LEYEK
.|...
yeall
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 173-305 5.4e-27 88.1 In-house 13-145 (148) alignment 
Range on Protein: 173-305
Range on HMM: 13-145/148.0
GFLYLGSQQDVMSEECLKNYGINYVLNVSRSCPIPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMRYL
.||.|||..  .. | ||. |.  . | ..... .      ..  ....|.  | .   |... .|..|.... . |.||.  |.|||  .|....... 
afLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfk

NMNVDEAYKYVKEKRATISPNFNFLGQLLEYEK
.. . ||. .||.||  . ||  || || |.|.
rvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_STYX_pd Subfamily STYX 173-307 7.2e-22 71.2 In-house 17-157 (166) alignment 
Range on Protein: 173-307
Range on HMM: 17-157/166.0
GFLYLGSQQDVMSE--ECLKNYGINYVLNVSRSCP----IPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIA
  |.||     |    | ||. || ... . ..       |.|  . ..  . | ||  |.|. .. .  ||||.  .  | |.||  |||||| .. ||
pglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalvia

FIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKII
.||    ..  ||..||.|.|  |.||  |  || ||| | 
yimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiy
DSPc Dual specificity phosphatase, catalytic domain 175-305 5.5e-44 144.3 Pfam-A 1-132 (133) alignment 
Range on Protein: 175-305
Range on HMM: 1-132/133.0
LYLGSQQDVMsEECLKNYGINYVLNVSRSCPIPEF--LPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMRYL
|||||... . ...|...||..|.||....| . .   .. .. ||||.|.. .|| ....|| |||.|... ...|.||| ||||||.|..||..|.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NMNVDEAYKYVKEKRATISPNFNFLGQLLEYEK
|....|||..|||.| .||||..||.||||||.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 175-305 5.5e-44 144.3 In-house 1-132 (133) alignment 
Range on Protein: 175-305
Range on HMM: 1-132/133.0
LYLGSQQDVMsEECLKNYGINYVLNVSRSCPIPEF--LPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMRYL
|||||... . ...|...||..|.||....| . .   .. .. ||||.|.. .|| ....|| |||.|... ...|.||| ||||||.|..||..|.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NMNVDEAYKYVKEKRATISPNFNFLGQLLEYEK
|....|||..|||.| .||||..||.||||||.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_MKPLT_pd Subfamily MKPLT 175-307 2.8e-25 82.7 In-house 29-160 (164) alignment 
Range on Protein: 175-307
Range on HMM: 29-160/164.0
LYLGSQQDVMSEECLKNYGINYVLNVSRSCpIPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMRYLNM
||||  ... .|. ||.  |....|||. .    |     . .. | |.  |.. .... | .|. .   . | |.|||  | ||| .|..||....   
lylGnakhatnekvlkdlkithivnvsqek.kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

NVDEAYKYVKEKRATISPNFNFLGQLLEYEKII
 ..|||.|.||.|. ..||  || || ..|..|
tlkeayeylkerrsivapnrGflkqlakfeeli
subfamily_MKPLV_pd Subfamily MKPLV 175-307 2.8e-25 82.7 In-house 29-160 (164) alignment 
Range on Protein: 175-307
Range on HMM: 29-160/164.0
LYLGSQQDVMSEECLKNYGINYVLNVSRSCpIPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMRYLNM
||||  ... .|. ||.  |....|||. .    |     . .. | |.  |.. .... | .|. .   . | |.|||  | ||| .|..||....   
lylGnakhatnekvlkdlkithivnvsqek.kdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw

NVDEAYKYVKEKRATISPNFNFLGQLLEYEKII
 ..|||.|.||.|. ..||  || || ..|..|
tlkeayeylkerrsivapnrGflkqlakfeeli
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 176-308 1.2e-21 70.3 In-house 7-142 (145) alignment 
Range on Protein: 176-308
Range on HMM: 7-142/145.0
YLGSQQDVMSEECLKNYGINYVLNVSRSCPIPE-FLPQT--HFHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMRYL
| ||     .  .|.. ||  ..|.. .  .    |     .   |   | .   .   |||  .|||| .     |.|||.||.||| ||..||.|.| 
yvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkyc

NMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKIIR
|| . || . |. .|    || .|| .||. || ..
nmtlseaarqvrsnrllaypnvtflknllnlekqlk
subfamily_MSG5_pd Subfamily MSG5 185-308 4.1e-17 55.8 In-house 38-161 (165) alignment 
Range on Protein: 185-308
Range on HMM: 38-161/165.0
SEECLKN-YGINYVLNVSRSCPIPEF-LPQTHFHRIpvRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMRYLNMNVDEAYKY
||  ||.   .. |.||..  .  |. .|  ... |  . .|  ||   . .  . |   .| .  ..|||  |.||| .. .|.||.| |. . .||. 
sepklkellsfdlvinvakeindlellvpavkyyhi..ewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydk

VKEKRATISPNFNFLGQLLEYEKIIR
.| .   |||.. .. ||.|.| .. 
lksvaddispsiglifqlmewevals
0040439 (Phosphotyrosine protein) phosphatases II 188-306 3.3e-25 84.6 In-house 73-244 (249) alignment 
Range on Protein: 188-306
Range on HMM: 73-244/249.0
CLKNYGINYVLNVSRSCPIP------------------------------------------EFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRS-
 |...||........ ..                                            .. .  . . |.. | .  .. |.|...|.||..||. 
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

-----ANGSVIVHCLAGISRSPTVAIAFIM-----RYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKI
      .| |.||| ||..|..|...|..|     ..|.....||.|.....|  . .|.... .|.|... 
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 188-305 3.2e-24 81.6 In-house 126-301 (307) alignment 
Range on Protein: 188-305
Range on HMM: 126-301/307.0
CLKNYGINYVLNVSRSCPIPE---------------------------FLPQTHFHRIPVRDN-----------------HGEKILPWFDEALEFIDKVR
 |...|............                               |.  . ....| |.                  . .. |.|.|.|.||..||
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

S------ANGSVIVHCLAGISRSPTVAIAFIMRYLN--------MNVDEAYKYVKEKRATISPNFNFLGQLLEYEK
.       .| |.||| ||..|..|...|..| ..         ....||.|...|.|  . .|.... .| |...
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0040438 (Phosphotyrosine protein) phosphatases II 188-311 7.2e-23 76.8 In-house 105-279 (317) alignment 
Range on Protein: 188-311
Range on HMM: 105-279/317.0
CLKNYGINYVLNVSRSCPIP--------------------------EFLPQTHFHRIPVRDN----------------HGEKILPWFDEALEFIDKVRSA
.....|....... ....                            | |.  . ....| |.                   .. |..|. |.|...||.|
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----NGSVIVHCLAGISRSPTVAIAFIM-----RYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKIIRTRQ
    .| |.||| ||..|. |...|..|     .. ...|.||.|...|.|. . ...... .| ...  . .| 
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_DSP23_pd Subfamily DSP23 188-289 1.3e-07 26.4 In-house 26-127 (148) alignment 
Range on Protein: 188-289
Range on HMM: 26-127/148.0
CLKNYGINYVLNVSRSC-PIPEFLPQTHFHRIPVRDNHGEkILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMRYLNMNVDEAYKYVKEK
 | . |. |.. ..  . |  |  |.  ..|. . | |    |   .| .. ...  . | .| |||| |  |. |.   ....  ..   ||   |...
ylldlgvrylvslteegrphveatpnltlvrlriddyhpp.aleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrl

RAT
|  
rpg
0043336 (Phosphotyrosine protein) phosphatases II 189-304 2.9e-19 65.1 In-house 153-273 (278) alignment 
Range on Protein: 189-304
Range on HMM: 153-273/278.0
LKNYGINYVLNVSR-SCPIPEFLPQTHFHRIPvrDNHGE-KILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIM-----RYLNMNVDEAYK
 ... . ..|.|..  .. . .  . |.. .|  |..    . . .|   ........ || |.||| ||..|. |.......     ........||.|
hlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavk

YVKEKRATISPNFNFLGQLLEYE
...|.|. . ...... .| |..
elreqRpgavqtpsqyrflyeal
0039614 (Phosphotyrosine protein) phosphatases II 190-306 1.8e-22 75.6 In-house 122-287 (297) alignment 
Range on Protein: 190-306
Range on HMM: 122-287/297.0
KNYGINYVLNVSRSCPI-----------------------------------------PEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRS---A
...|....... . ..                                           | .  |||. ..  |..   .|  ..|.||.......    
weqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

NGSVIVHCLAGISRSPTVAIAFIM-----RYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEKI
.| |.||| ||..|. |...|..|     .. ...|.||.|...|.|  . ...... .| .... 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0036941 (Phosphotyrosine protein) phosphatases II 190-306 5.8e-21 70.5 In-house 149-275 (297) alignment 
Range on Protein: 190-306
Range on HMM: 149-275/297.0
KNYGINYVLNVSRScPIPEFLPQTHFHRIPVRDNhgeKILPWFDEALEFIDKVRS------ANGSVIVHCLAGISRSPTVAIAFIM--------RYLNMN
... . ..| |.     .| .  |||| .   |.   .. ..... |.||..||.       .| |.||| ||..|| |...|..|        .. ...
lddytlrtlevtdt.gngesrtvthfhytgwpdh...gvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd

VDEAYKYVKEKRATISPNFNFLGQLLEYEKI
. ||.|...|.|. . ...... .| |..  
ileavkklReqRpgavqtleqyrflyealle
0038934 (Phosphotyrosine protein) phosphatases II 190-311 5.2e-20 67.4 In-house 53-180 (194) alignment 
Range on Protein: 190-311
Range on HMM: 53-180/194.0
KNYGINYVLNVSR--SCPIPEFLPQ--THFHRIPVRDNHG----EKILPWFDEALEFIDKvrSANGSVIVHCLAGISRSPTVAIAFIMRYLNMNVDEAYK
.|... .|....    .  || ...   .....|. | .     | .| ..| . ||...  ...| | ||| ||..|..|...|... .|.|...||..
lnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAia

YVKEKRATISPNFNFLGQLLEYEKIIRTRQ
...|||  . || ..| .||.. | .| ..
lfrekRpgaipnqdyleallkrykelrkav
0047943 (Phosphotyrosine protein) phosphatases II 190-301 1.7e-17 59.2 In-house 147-265 (273) alignment 
Range on Protein: 190-301
Range on HMM: 147-265/273.0
KNYGINYVLNVSR-SCPIPEFLPQTHFHRIPvrDNHGEKILPWFDEALEFIDKVRS---ANGSVIVHCLAGISRSPTVAIAFIM-----RYLNMNVDEAY
|.. . ..| ... ... . .  . |.. .|  |..    |  . | .|...|...    || |.||| ||..|. |.......     .. ...|.||.
kddytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleav

KYVKEKRATISPNFNFLGQLL
|.....|  . ...... .| 
kllrsqRpgmvqtpeqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 190-295 9.7e-15 50.2 In-house 159-273 (288) alignment 
Range on Protein: 190-295
Range on HMM: 159-273/288.0
KNYGINYVLNVSR-----SCPIPEFLPQTHFHRIPvrdnhGEKILPWFDEALEFIDKVRSA----NGSVIVHCLAGISRSPTVAIAFIM-----RYLNMN
... . ..| |..      .  . .  . |.. .|        . . ... |.|. .||.|    .| |.||| ||..|. |.......     .   ..
lddytvrtlevtnldlldgdgesrtvthfhytnwp.....dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd

VDEAYKYVKEKRATISPNFN
| ||.|...|.|  . ....
vleavkrlreqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 190-291 6.5e-14 47.4 In-house 145-257 (284) alignment 
Range on Protein: 190-291
Range on HMM: 145-257/284.0
KNYGINYVLNVSRSCPIPEFLPQTHFHRIPVRDNHGEKILPWFDEALEFIDKVRSA---NGSVIVHCLAGISRSPTVAIAFIMRYL--------NMNVDE
|.. . ..| ...  .  | .  |||| ..  |..    . .. | |.........   .| ..||| ||..|. |.... .. ..        ...| |
kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvle

AYKYVKEKRATIS
|.|...|.|    
avkrlreqRpgmv
0050432 (Phosphotyrosine protein) phosphatases II 190-294 1e-13 46.8 In-house 178-285 (308) alignment 
Range on Protein: 190-294
Range on HMM: 178-285/308.0
KNYGINYVLNVSR-SCPIPEFLPQTHFHRIPvrdnhGEKILPWFDEALEFIDKVRSA--NGSVIVHCLAGISRSPTVAIAFIM-----RYLNMNVDEAYK
... . ..| ..  ...   .. . |..  |       .. | ... |.|...||.   .| ..||| ||..|. |.... ..     .  ...| ||.|
lddytvrtleltnlgdgesrtvthfhytnWp.....dhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavk

YVKEKRATISPNF
...|.|.   ...
klReqRpgmvqtp
Y_phosphatase Protein-tyrosine phosphatase 198-287 6.9e-07 24.3 Pfam-A 121-216 (235) alignment 
Range on Protein: 198-287
Range on HMM: 121-216/235.0
LNVSRSCPIP--EFLPQTHFHRIPVRDNHgEKilpwFDEALEFIDKVRSAN----GSVIVHCLAGISRSPTVAI-AFIMRYLNM----NVDEAYKYVKEK
|... ..     . . | |..  | ..   |.     .. |..|.||.. .    |.|.||| ||..|. |..   .... |.     .| .. | ....
lelkkkkeesekrevkqlhytnWpdhgvp.es....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkq

R
|
R
Y_phosphatase Protein-tyrosine phosphatase 198-287 6.9e-07 24.3 In-house 121-216 (235) alignment 
Range on Protein: 198-287
Range on HMM: 121-216/235.0
LNVSRSCPIP--EFLPQTHFHRIPVRDNHgEKilpwFDEALEFIDKVRSAN----GSVIVHCLAGISRSPTVAI-AFIMRYLNM----NVDEAYKYVKEK
|... ..     . . | |..  | ..   |.     .. |..|.||.. .    |.|.||| ||..|. |..   .... |.     .| .. | ....
lelkkkkeesekrevkqlhytnWpdhgvp.es....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkq

R
|
R
PTPc_DSPc_SM00012 214-275 2.8e-07 26.1 In-house 4-68 (105) alignment 
Range on Protein: 214-275
Range on HMM: 4-68/105.0
HFHRIPVRDNhgeKILPWFDEALEFIDKVRSANG------SVIVHCLAGISRSPTVAIAFIMRYLNMN
|.|     |    ..  . |. ||....|.. .       .|.||| ||..|. |.. . |.   ...
hyhytgwpdh...gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqlek
subfamily_PTPMT1_pd Subfamily PTPMT1 215-305 2.6e-15 51.3 In-house 76-166 (171) alignment 
Range on Protein: 215-305
Range on HMM: 76-166/171.0
FHRIPVRDNHGEKILPWFDEALEFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMRYLNMNVDEAYKYVKEKRATISPNFNFLGQLLEYEK
. .... |  ..  |    ...|||.||.|   .| ||| || .|| |......|   ... .|| |..|.|| .|  . . . .| |||.
qlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee
0048567 (Phosphotyrosine protein) phosphatases II 231-291 3.2e-08 28.1 In-house 59-122 (157) alignment 
Range on Protein: 231-291
Range on HMM: 59-122/157.0
WFDEALEFIDKVRSANGSVIVHCLAGI---SRSPTVAIAFIMRYLNMNVDEAYKYVKEKRATIS
..  . .|.. .. |.. ..||| ||    .|. |.. .... .|... .||.....  | .. 
FilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsv
subfamily_CDC14_pd Subfamily CDC14 237-287 6.3e-06 20.2 In-house 254-304 (328) alignment 
Range on Protein: 237-287
Range on HMM: 254-304/328.0
EFIDKVRSANGSVIVHCLAGISRSPTVAIAFIMRYLNMNVDEAYKYVKEKR
.|.. . .|.|...||| ||. |  |.  ...|.  ...  ||  ...  |
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricr
subfamily_PRL_pd Subfamily PRL 244-289 2.1e-06 21.9 In-house 88-132 (151) alignment 
Range on Protein: 244-289
Range on HMM: 88-132/151.0
SANGSVIVHCLAGISRSPT-VAIAFIMRylNMNVDEAYKYVKEKRAT
... .| |||.||. |.|  ||.|.|     |. ..| ....|||  
epkstvavhcvaGlGraPvlvalaliea..Gmkyedavefirekrrg