Gene SpurDSP-Un-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP021_AA protein Get Run
SpurP021_AA_265-411 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 157-242 9.5e-11 34.2 Pfam-A 14-111 (113) alignment
Range on Protein: 157-242
Range on HMM: 14-111/113.0
MLILDVRDRADYNASHVTTARHSTA------------VDTEHDCLVSQGKLDKFTMVVVYD-QGSTSQTVDPTLSSF-VQRLKDAnvDVLILSGGYDTFH
...||||. ..|...|.. |..                ... ..  |. |||| . ||||. .|  |...  .|  . ...|     .| .| ||.. ..
vvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktvvvycrsgnrsggaaalllalilkelgyk..nvyvLdGGfeawk





subfamily_MKPLT_pd Subfamily MKPLT 167-226 4.8e-19 62.5 In-house 31-90 (164) alignment
Range on Protein: 167-226
Range on HMM: 31-90/164.0
DYNASHVTTARHSTAVDTEHDCLVSQGKLDKFTMVVVYDQGSTSQTVDPTLSSFVQRLKD
  ||.|.|...........|...|||.|.|.|...|.|.|.......|..||||..|...
lGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraak

subfamily_MKPLV_pd Subfamily MKPLV 167-226 4.8e-19 62.5 In-house 31-90 (164) alignment
Range on Protein: 167-226
Range on HMM: 31-90/164.0
DYNASHVTTARHSTAVDTEHDCLVSQGKLDKFTMVVVYDQGSTSQTVDPTLSSFVQRLKD
  ||.|.|...........|...|||.|.|.|...|.|.|.......|..||||..|...
lGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraak

0049772 (Phosphotyrosine protein) phosphatases II 238-406 9.8e-29 96.5 In-house 155-272 (314) alignment
Range on Protein: 238-406
Range on HMM: 155-272/314.0
YdtfhktypflcnsltirseqdrmlhfksypsvvledtlyqgNVKHSKNETVLKnlkithilnvsTEC--ANAFPKS-FEYLQVKVEDeSTEHIGPHLER
.                                         |  . ..   ||           .|.  .. |..  ..||.. |.|  .. .  ....
g.........................................neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfde

AAKFVASAiNSGGRVFVHCVQGKSRSST-CTIAFLMSYRGWTLKDAHEYLKDRRSiAAPNRGFLIQLSKFEQL
. .|. .| . ||.|.|||  ||.|. | ...|.||...|..|..| |... .|. . ||.||. ||  .|. 
flefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi

0039614 (Phosphotyrosine protein) phosphatases II 246-406 5.6e-19 64.1 In-house 20-287 (297) alignment
Range on Protein: 246-406
Range on HMM: 20-287/297.0
PFLCNSLTIRSEQDRMLHFKSYPSVVLEDTLYQGNVKHSKNETV--------------------------------------------------------
..|.  ..  | .  .|.|....|.. . . ..  .  .||  .                                                        
dlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

-LKNLKITHILNVSTECANAFpKSFEYL-------------------------------------------QVKVEDESTEHIGPHLERAAKFVASAIN-
 ......|.|... ... .   | ..|                                             ..  | .. ..  .| .. ..| .|.. 
mvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--SGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
  .||.| |||. |..|. |  .|.||     ...|.....| ..|. .|. | .. .....| .... 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

subfamily_MKPLT_pd Subfamily MKPLT 247-411 4.7e-93 303.2 In-house 1-164 (164) alignment
Range on Protein: 247-411
Range on HMM: 1-164/164.0
FLCNSLTIRSEQDRMlHFKSYPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSG
||...|..|.|.|.. ..|.|||||||||||.||.||..||.|||.||||||.|||.|...|||||.|||||||||||.|.....|||||||.|.||.||
fLitdldvrdeeDyk.rikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsG

GRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGKV
|||.|||||||||||..|.|||....|||||.|.||||.||||.|||||||.||.|||.|..|||
GrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGkv

subfamily_MKPLV_pd Subfamily MKPLV 247-411 4.7e-93 303.2 In-house 1-164 (164) alignment
Range on Protein: 247-411
Range on HMM: 1-164/164.0
FLCNSLTIRSEQDRMlHFKSYPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSG
||...|..|.|.|.. ..|.|||||||||||.||.||..||.|||.||||||.|||.|...|||||.|||||||||||.|.....|||||||.|.||.||
fLitdldvrdeeDyk.rikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsG

GRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGKV
|||.|||||||||||..|.|||....|||||.|.||||.||||.|||||||.||.|||.|..|||
GrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGkv

PTEN_1 260-405 1.1e-27 92.1 In-house 31-189 (196) alignment
Range on Protein: 260-405
Range on HMM: 31-189/196.0
RMLHFKSYP--SvVLEDTLYQGNVKHS-KNETVLKNLKITHILNVSTECAN---------AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAI--NS
 | .. | |  .  ....||.|..|.  ..   ||  .||...|.| |...         .| . .|||.. .||  .  .  ... ...|  ...  ..
amgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn

GGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
|. | ||| .|..|| |  .|.||.....| ..| |.....|. .||| ... .| ....
gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfa

subfamily_LRR-DSP_pd Subfamily LRR-DSP 261-408 1.7e-31 103.3 In-house 113-259 (263) alignment
Range on Protein: 261-408
Range on HMM: 113-259/263.0
MLHFKSYPSVVLeDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQV-KVEDESTEHIGPHLERAAKFVASAINSGGrVFVHCVQGKSR
..   | |. .. | |. |  . ..|...||.| .||||   ...   ||| | || . ..||    .|  |.|.   |. .  ..|| |.|||  | ||
itlvssvPdeii.dklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsr

SSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTF
||| .|..|| ..  ..|.| .  . .|.   ||.||. || |.|.  |
sstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf

0044763 (Phosphotyrosine protein) phosphatases II 263-407 2e-35 117.4 In-house 18-170 (178) alignment
Range on Protein: 263-407
Range on HMM: 18-170/178.0
HFKSYPSVVLEDtLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKS---------FEYLQVKVEDESTEHIGPHLERAAKFVASAI-NSGGRVFVH
 .  ..| .|.. || |.  ....   ||.|.||||.|...|. . |.|.         ..||.. ..| ..  .  |.... .|. .|. ..||.|.||
sdyinaseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSiAAPNRGFLIQLSKFEQLT
|  |..|| |. .|.|| ..|..| .| |... ||. . ||.|.| || .||.  
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl

subfamily_STYXL1_pd Subfamily STYXL1 263-410 2.8e-30 98.6 In-house 6-156 (157) alignment
Range on Protein: 263-410
Range on HMM: 6-156/157.0
HFKSYPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTE---CANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSR
..|.||. || . || || |...|... |.||.   .|||..     .. ..  . |...||||   .. ..|..| .|. .  ..|  |.|   .| ||
elktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisr

SSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGK
| .  ||.|| .. .|||.|..|||. ..   |||.|. |||..|.  .|.
saaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllge

subfamily_DSP1_pd Subfamily DSP1 264-406 3.4e-46 151.3 In-house 12-155 (163) alignment
Range on Protein: 264-406
Range on HMM: 12-155/163.0
FKSY-PSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSST
 | | |.  . | || |  ... |  .||.|.||.|||||.|. |.|.. ||| ..|.||.... |  ..|.. .|. ......|.|..|| .| |||||
lklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsst

CTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
  .|.||. . ..|..|... |.||||  || ||  || ..|. 
lclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk

subfamily_DSP10_pd Subfamily DSP10 264-405 2.4e-36 119.0 In-house 9-151 (159) alignment
Range on Protein: 264-405
Range on HMM: 9-151/159.0
FKSYPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPK-SFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSST
... | . .   |. |. | ......|..|.||..||| |.. | | . ...| ...|.| |....  . | | .|.  | ..| ||.|||  | |||.|
ietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsat

CTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
 .||.|| ... .|.||... |..|.| .|| .|. || .||.
vviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefek

subfamily_DSP6_pd Subfamily DSP6 265-405 1.9e-34 112.4 In-house 11-152 (158) alignment
Range on Protein: 265-405
Range on HMM: 11-152/158.0
KSYPSVVLEdTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPK--SFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSST
...|  .|. .|| |. |...|  |||.||| ..||| ..  |.| .  ...|||. .||. .. .  ..  | .|.  | ..   |.|||  | ||| |
aefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

CTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
 |.|.||...  .|.||....|.|.|  .||  |. || .||.
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfer

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 265-405 1.2e-32 106.4 In-house 4-145 (148) alignment
Range on Protein: 265-405
Range on HMM: 4-145/148.0
KSYPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFP-KSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTC
. .|| . .  |. |. |.  .  .||.| .|.| | . |. ||.  .. |||.|...|.  | .    | ...||  | . |.|| ||.  | |||| .
rtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssal

TIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
....|. ..  .||.| .. |..|    || ||| || ..||
allwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq

0045098 (Phosphotyrosine protein) phosphatases II 265-407 1.5e-23 79.0 In-house 19-271 (278) alignment
Range on Protein: 265-407
Range on HMM: 19-271/278.0
KSYPsVVLEDTLYQGNVK-----------------------------------------HSKNETVLKNLKITHILNVSTE-------------------
 ..|    .. || ||..                                         ....   |..|.||.|... ..                   
lgip.seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

---------------------------------CANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAIN--------------SGGRVFVHCVQGK
                                 . ... . . || .   .  ...|  .. .. .|. .|..              |||.|.|||  |.
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSSTCTIAFLMSYR---GWTLKDAHEYLKDRRSI-AAPNRGFLIQLSKFEQLT
.|. |  .|.|| ..   |..| .| ..|. .| . | .| .....| .|... 
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel

0051429 (Phosphotyrosine protein) phosphatases II 266-408 6.2e-18 60.9 In-house 14-225 (272) alignment
Range on Protein: 266-408
Range on HMM: 14-225/272.0
SYPSVVLEDTLYQGNVK---HSKNETVLKNLKITHILNVSTECANAFPK------SFEYLQVKVEDESTEHIG---------------------------
 | .||....|| ..       ..   ||.|.|..|... .|.  .. |       ..||.. ..|.|.. |                            
gygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltll

------------------------PHLERAAKFVASainsGGRVFVHCVQGKSRSSTCTIAFLMSyRGWT--------------LKDAHEYLKDRRSIAA
                          | .. .....    ||.| |||  ||.|. |   ..|.  .|..              | .| |.|...|  | 
lsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgav

PNRGFLIQLSKFEQLTF
.. .....| ....  .
qteeqylflyeallell

0048076 (Phosphotyrosine protein) phosphatases II 267-406 1.1e-33 111.3 In-house 3-141 (145) alignment
Range on Protein: 267-406
Range on HMM: 3-141/145.0
YPSVVLEDtLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIA
.|| .|.. || |.. . ..   ||.|.||..||...|. . ... ..||.. ..| ..  .  .|... .|. .|...||.|.|||  |..|. |  .|
wpseilpg.lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

FLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
.|| ..|..| .| |... .|..| || |.|..| .||. 
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefele

0048179 (Phosphotyrosine protein) phosphatases II 267-405 2.1e-32 107.2 In-house 3-142 (144) alignment
Range on Protein: 267-405
Range on HMM: 3-142/144.0
YPSVVLEDtLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSF--EYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCT
.|| .|.. || |.. ....   ||.|.||...|...|. ..|.. .  .||.. ..| ..  .  .|... .|. .|...||.|.|||  |..|. |  
npseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

IAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
.|.|| ..|..|..| .... ||..| ||.|.|..| ..|.
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek

0041856 (Phosphotyrosine protein) phosphatases II 268-411 9.2e-29 95.7 In-house 18-176 (182) alignment
Range on Protein: 268-411
Range on HMM: 18-176/182.0
PSVVLEDTLYQGNVKH--------------SKNETVLKNLKITHILNVSteCANAFPKSF-----EYLQVKVEDESTEHigphLERAAKFVASAINSGGR
..    . || |. ..               .. . ||.|.||.|.|..  . . .|. .     .||.. ..| ..      |. . .|.  ....||.
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRS--IAAPNRGFLIQLSKFEQLTFGKV
|.|||  |..|. |  .|.|| ..|..| .| .... ||.  .  || .|..||  .| | ..| 
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt

subfamily_MSG5_pd Subfamily MSG5 268-405 1.1e-14 47.9 In-house 26-158 (165) alignment
Range on Protein: 268-405
Range on HMM: 26-158/165.0
PSVVLEDTLYQgnvkHSkNETVLKNLKITHILNVSTECANA---FPKsFEYLQVKVEDESteHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCT
| .|| . ||     .| . .. . | .  ..||. |  .     |   .|  .. | .|  .|   | | .. . .|   . ...|||  | |||..  
pllvlpeklyl....ys.epklkellsfdlvinvakeindlellvpa.vkyyhiewehds..kivkdlsrltriihaatskrkkilvhcqcglsrsasli

IAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
.|..| | . .|.||.. || .    .|. |...|| ..| 
vayimkyynlslrdaydklksvaddispsiglifqlmewev

PTPc_motif_SM00404 269-405 1.5e-37 123.6 In-house 3-139 (140) alignment
Range on Protein: 269-405
Range on HMM: 3-139/140.0
SVVLEDtLYQGNVKHSKNETVLKNLKITHILNVSTECAN-AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAF
| .|.. || |. ....|. .||.|.|||..||..|. .    ..|..||....|. .... ..|.....|. .|...||.|.|||  | ||| | .||.
srilph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
||.||...|..| |..|.||.|  || .|. || ..|.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek

subfamily_DSP19_pd Subfamily DSP19 271-405 3.9e-38 125.2 In-house 14-148 (152) alignment
Range on Protein: 271-405
Range on HMM: 14-148/152.0
VLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMS
..|..|| | .   .... ||. ||||||||.|.  |.||| |.||.... |.. ...  .|..| .|. .| .. |.|.|||  | |||..  ||.||.
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

YRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
 .  .|..| |.... |  . || ||. || ..|.
keelsleealelvrearpcikPneGFikqLkeyea

subfamily_Slingshot_pd Subfamily Slingshot 272-406 4.3e-33 108.1 In-house 22-156 (169) alignment
Range on Protein: 272-406
Range on HMM: 22-156/169.0
LEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSY
. | .| |    . |   ||. ....||||. |. | ||..||||...| ||..... .. ... ||.  | ..| .|.|||  | |||..  ||. |  
ifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamke

RGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
 |..|..|.||.|.|||.. ||.||| ||...| .
yglsleealeyvkerrsvikPnkgflkqleeyeGi

0049260 (Phosphotyrosine protein) phosphatases II 272-406 3.3e-25 84.0 In-house 11-148 (152) alignment
Range on Protein: 272-406
Range on HMM: 11-148/152.0
LEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPK---SFEYLQVKVEDESTEHIGPHLERAAKFVAS-AINSGGRVFVHCVQGKSRSSTCTIAF
   |.. |.  ....   ||.|.||.|... ... ....|    ..||.. ..| ..  .  .|. . .|.   |...||.|.|||. |..|. |  .|.
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

LMSyRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
||  .|..|..| .... .|..| || |.|..| .||.|
lml.lgvsleeavalvrekRpgavpnpgqlrflyefekl

0051082 (Phosphotyrosine protein) phosphatases II 272-400 2.4e-20 68.1 In-house 11-146 (151) alignment
Range on Protein: 272-400
Range on HMM: 11-146/151.0
LEDTLYQGNVKHSKNETVLKNLKITHILNVST-----ECANAFPK-SFEYLQVKVEDESTEHIGPHLERAAKFVASAINS-GGRVFVHCVQGKSRSSTCT
... || ..  .. .   ||.|.|..|.|. .      |.. .|. ..|.|.. ..| ..  .  ... ...|.  ...  .| |.|||  ||.|. |  
vtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

IAFLMSyRGWTLKDAHEYLKDRRS-IAAPNRGFLIQL
...||  .|..| .| |... .|  .  || .||.||
alylml.lgvsleealeeyrlkrpgvvqpnqqflfql

subfamily_DSP12_pd Subfamily DSP12 273-407 6.2e-32 105.1 In-house 6-143 (155) alignment
Range on Protein: 273-407
Range on HMM: 6-143/155.0
EDTLYQGNVKHSKNETVLKNLKITHILNVSTECA---NAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLM
.. || |.... ..|. ||.|||||.| | .|     .. ..  ....... || .| |  ||..| .|. .|.. .| |.|||  | |||.|  ||.||
lpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlm

SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLT
 . .. |..|.. .|. .. . || ||| ||  ||.. 
kkeklslekAlklvkekkpeiepNegFleQLklfekmg

0046846 (Phosphotyrosine protein) phosphatases II 273-408 1.2e-25 85.7 In-house 16-173 (176) alignment
Range on Protein: 273-408
Range on HMM: 16-173/176.0
EDTLYQGNVK----------HSKNETVLKNLKITHILNVSTEC-------ANAFPK----SFEYLQVKVEDESTEHIgPHLERAAKFVASAINSGGRVFV
 . |. |.            . ..   ||.|.||...|. .|        .| .|     ...||.. ..| ..  .  .|... .|. .|...||.| |
nanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlV

HCVQGKSRSSTCTIAFLMSY-RGWTLKDAHEYLKDRRS-IAAPNRGFLIQLSKFEQLTF
||. |..|. |  .|.|. . .|... .| ......|.  | ...... .| .||.| .
HCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll

0036282 (Phosphotyrosine protein) phosphatases II 273-407 2.2e-22 75.0 In-house 16-169 (174) alignment
Range on Protein: 273-407
Range on HMM: 16-169/174.0
EDTLYQGNVKHSkNETVLKNLKITHILNVSTECANA---------------FPKSFEYLQVKVEDESTEHIGPhLERAAKFVASAINS--GGRVFVHCVQ
 . |. |.. .. .   ||.|.||..... .|. .                 .  ..||.. ..| ..  .   |... ||| .|...  || | |||  
tprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsa

GKSRSSTCTIAFLMSYRGW-TLKDAHEYLKDRR---SIAAPNRGFLIQLSKFEQLT
|..|. |  .|.|| .... .| || .... .|   . . .. .....| .||.| 
GvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll

subfamily_DSP14_pd Subfamily DSP14 274-411 2.1e-39 129.0 In-house 12-148 (157) alignment
Range on Protein: 274-411
Range on HMM: 12-148/157.0
DTLYQGnVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRG
..|. .    ......||. |||.|.||..|  |   |..|...|.|||...... .|....|. . .. ..||.. |||| | ||| . ..|.|| |. 
psLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyek

WTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGKV
 .|..|....|..|.|  || ||  || ..|.  .||.
lsLreayklvksaRpiirPNvGFwkqlidyEkklkgks

subfamily_DSP3_pd Subfamily DSP3 274-404 3.2e-31 102.2 In-house 16-154 (162) alignment
Range on Protein: 274-404
Range on HMM: 16-154/162.0
DTLYQGNVKHSKNETVLKNLKITHILNVSTEC------ANAFP--KSFEYLQVKVEDESTEHIGPHLERAAKFVASAINS-GGRVFVHCVQGKSRSSTCT
..|| |. . .|... ||.| |||.|| .          . |    ...|| ..|.|  . ..  . |.||||...|...  |.|.||||.| |||.|. 
pklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlv

IAFLMSYRGWTLKDAHEYLKDRRSIaAPNRGFLIQLSKFE
.|.|| .|  ||..| .  ...|.|  ||.||| || ...
layLmirrkmtlveairtvrkkRei.lPneGFlkqLaeld

subfamily_DSP8_pd Subfamily DSP8 274-405 3e-28 92.4 In-house 20-152 (159) alignment
Range on Protein: 274-405
Range on HMM: 20-152/159.0
DTLYQGNVKHSKNETVLKNLKITHILNVSTECAN-AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYR
. || |  |.. .|..|..| |...||.|..| .  . |  ..|.| |.|. .|.. | .... .|.  | .. |||.||.  |.|||.|  ||..| . 
knlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktl

GWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
  .| .|....|..|    ||  || || ..|.
emsldeayrfvkekrptispnlnflgqLleyek

0043147 (Phosphotyrosine protein) phosphatases II 274-407 1.6e-27 91.7 In-house 24-160 (172) alignment
Range on Protein: 274-407
Range on HMM: 24-160/172.0
DTLYQGNVKHSKNETVLKNLKITHILNVSTE---CANAFPKSFEYLQVKVEDESTEhIGPHLERAAKFVAS--AINSGGRVFVHCVQGKSRSSTCTIAFL
.|.. ..  ....   ||.|.||||.|. ..   . . ..  ..|| . ..| ..  .  .|... .|. .  |...||.| |||. |..|. |  .|.|
atqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaayl

MSyRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLT
|  .|..| .| ......|..| .| .....| .||.| 
ml.lglsleeavalvrekRpgavqnpsqyrflyyfekll

0037934 (Phosphotyrosine protein) phosphatases II 274-405 2.7e-22 74.9 In-house 44-239 (243) alignment
Range on Protein: 274-405
Range on HMM: 44-239/243.0
DTLYQGNV--------KHSKNETVLKNLKITHILNVSTEC---------------------------------------------ANAFPKSFEYLQVKV
..|. ...        .. ..   |..|.||.|... ...                                              . .   . |... .
prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpw

ED----ESTEHIGPHLERAAKFVAS-----AINSGGRVFVHCVQGKSRSSTCTIAFLMSYR-GWTLKDAHEYLKDRRSI-AAPNRGFLIQLSKFEQ
 |    .|.|..  .|. . .|. .     |..|||.| |||. |..|. |  .|.|| .. |..| .| ..|...|.  | ........| ....
pdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_DSP15_pd Subfamily DSP15 275-407 3.2e-32 105.7 In-house 8-139 (151) alignment
Range on Protein: 275-407
Range on HMM: 8-139/151.0
TLYQGNVKHSKNETVLKNLKITHILNVSTeCANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGW
 || ||.. ||.|. ||. .|||||.|.   |. . | .||. ....| .  ..  ... . .|. ..   .. |.|||. | ||| | ..|.||.    
glylgnfrdskdeelLkeknithilsvhd.nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtel

TLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLT
  .|| | .| .||.| || ||  || ..|. .
nwrdalevikaaRsvanPnfGfkrqlkeyektk

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 275-405 1.7e-26 86.4 In-house 9-150 (154) alignment
Range on Protein: 275-405
Range on HMM: 9-150/154.0
TLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKS---------FEYLQVKVEDESTEHIGPHLERAAKFVASAI--NSGGRVFVHCVQGKSRSSTC
 || .  . . |   |.. .|..||||..   |.|..          .|||.... |.   .|  .|..| .|. .||     ..|.||. .| |||.. 
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
 |..||  .  .|  | | ||| | |  ||.||| || .||.
lisylmdklkislslalellkdsryiikPnqGflkqleifek

DSPc Dual specificity phosphatase, catalytic domain 276-405 2.3e-36 119.6 Pfam-A 1-132 (133) alignment
Range on Protein: 276-405
Range on HMM: 1-132/133.0
LYQGNVKHSKnETVLKNLKITHILNVSTECAN---AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYR
|| |. .... ...|..|.||...||..|. |     ....|||...||||... | ..||.| .|...|...|..|.|||  | ||| | .||.||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
...|..| |..|.|||.  || ||| || ..|.
nlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 276-405 2.3e-36 119.6 In-house 1-132 (133) alignment
Range on Protein: 276-405
Range on HMM: 1-132/133.0
LYQGNVKHSKnETVLKNLKITHILNVSTECAN---AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYR
|| |. .... ...|..|.||...||..|. |     ....|||...||||... | ..||.| .|...|...|..|.|||  | ||| | .||.||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
...|..| |..|.|||.  || ||| || ..|.
nlslneAyefvkerrskispnagflrqLleyer

0042113 (Phosphotyrosine protein) phosphatases II 276-405 2.1e-20 68.6 In-house 54-240 (245) alignment
Range on Protein: 276-405
Range on HMM: 54-240/245.0
LYQGNVKHSKNET----VLKNLKITHILNVSTECANAFPKSFE----------------------------------------------YLQVKVEDEST
.. ..  ....       |..|.||.|.....|  . ..|...                                              |... ..| ..
fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgv

EHIGPHLERAAKFVASAIN--SGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
 ..  .|... .|| .|..  |.|.|.|||  |..|. |  .|.||     ...|..| .| ..|...|. | .. .....| ....
pdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 276-404 2.8e-20 65.9 In-house 6-138 (145) alignment
Range on Protein: 276-404
Range on HMM: 6-138/145.0
LYQGNVKHSKNETVLKNLKITHILNVSTE----CANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSY
|| | . |... ..|..| |. |.|...     . ..  .|.| | .  ||  .  .  |..  . |.    . |  |||||. | ||| | ..|||| |
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

RGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFE
 . || .|   .. .|  | ||  || .| ..|
cnmtlseaarqvrsnrllaypnvtflknllnle

0045450 (Phosphotyrosine protein) phosphatases II 281-405 1.6e-20 69.5 In-house 102-301 (307) alignment
Range on Protein: 281-405
Range on HMM: 102-301/307.0
VKHSKNE----------------TVLKNLKITHILNVSTECANAF-------PKS---------------------FEYLQVKVEDE-------------
. ..|..                  |.....|.|....... ...       | .                     . .....|.|              
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfh

----STEHIGPHLERAAKFVASAIN------SGGRVFVHCVQGKSRSSTCTIAFLMSYRG--------WTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
       .. |..| . .|.  . .      .||.| |||  |..|. |  .|.|| ...        ..| .| ..|...|. | .| .....| ....
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall





subfamily_STYX_pd Subfamily STYX 283-410 4.2e-23 75.2 In-house 29-160 (166) alignment
Range on Protein: 283-410
Range on HMM: 29-160/166.0
HSKNEtVLKNLKITHILNVSTEC-----ANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLK
.|| | |||.  ||||. .  .         ||..| || . | |...| |  .| .  .|. .....||.|.||   | |||..  ||..|   |   .
kskle.vlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyr

DAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGK
.|. |...||   .|| ||  || ..| . . |
eafayvqerrfcinpnegfvsqlkeyeaiylak

0038934 (Phosphotyrosine protein) phosphatases II 284-408 1.6e-17 59.2 In-house 46-177 (194) alignment
Range on Protein: 284-408
Range on HMM: 46-177/194.0
SKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIG--PHLERAAKFVASA-----INSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTL
  .   |.| |........ .     |. || . ... .  ..  |  | ||   .|.  .      ..|| | |||. |..|. |  .|.|. ..|...
lvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsa

KDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTF
..| ......|  | ||...| .| |. . ..
eeAialfrekRpgaipnqdyleallkrykelr

0051299 (Phosphotyrosine protein) phosphatases II 284-393 2.5e-08 29.2 In-house 153-271 (288) alignment
Range on Protein: 284-393
Range on HMM: 153-271/288.0
SKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKV----EDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGW
 ..|.||.. .....  . ..  .   .|... .  .    ..   ... . |.   ..  .  ..|| | |||  |..|. |  ...|.       .|.
llseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggv

TLKDAHEYLKDRRSIAAPN
.. .| ..|. .|  . ..
dvleavkrlreqRpgmvqt

0036941 (Phosphotyrosine protein) phosphatases II 285-407 4.7e-16 54.4 In-house 35-276 (297) alignment
Range on Protein: 285-407
Range on HMM: 35-276/297.0
KNET----------------------------------------------------------VLKNLKITHILNVSTECANAFPKSFEYLQVK-------
...                                                            . ....|.|......  . ..| ..|   .       
llpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslty

------VEDES----------------------------------TEHIGPHLERAAKFVASAIN------SGGRVFVHCVQGKSRSSTCTIAFLM----
      . ...                                    .. .. .   .|.  . .      |||.| |||. |..|| |  .|.||    
gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqql

----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLT
     ..|.....|  .|...|  | .. .....|  ...  
edklkeggvdileavkklReqRpgavqtleqyrflyeallel

0040439 (Phosphotyrosine protein) phosphatases II 288-406 3.7e-22 74.6 In-house 72-244 (249) alignment
Range on Protein: 288-406
Range on HMM: 72-244/249.0
TVLKNLKITHILNVSTECAN-------------------------------------------AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAIN
  |..|.||.|....... .                                            ...|...|.. . |    .. |..| . .|.  . .
rmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrk

------SGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
      .||.|.|||  |..|. |  .|.||      ..|..|..| ..|...|. | .| .....| .... 
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

0040438 (Phosphotyrosine protein) phosphatases II 288-408 2.5e-17 58.6 In-house 49-276 (317) alignment
Range on Protein: 288-408
Range on HMM: 49-276/317.0
T-------------------------------------------------------VLKNLKITHILNVSTECANA------------------------
                                                         ......|.|... ... .                         
ypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtll

---FPKSFEYLQVKVEDE----------------STEHIGPHLERAAKFVASAINS----GGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAH
     .........|||                    .. |...   .|.  . ..    || | |||. |..|. |  .|.||      ..|.....| 
seeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeav

EYLKDRRSIAAPNRGFLIQLSKFEQLTF
..|. .|. | .. .....| ....  .
kelreqRpgavqtpeqyrflydalleyl

0043336 (Phosphotyrosine protein) phosphatases II 289-404 3.2e-14 48.5 In-house 107-273 (278) alignment
Range on Protein: 289-404
Range on HMM: 107-273/278.0
VLKNLKITHILNVSTECANAFPKSFEYL----------------------------QVKVEDESTE------------------HIGPHLERAAKFVASA
 ...|..|.|... ..  .  .|...|                              |.   .. .                  .. ..|.   ..    
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

INSGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFE
 .|.| | |||. |..|. |  ...|.     ...|..| .| ..|. .|  | ..  ....| ...
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

subfamily_PTPMT1_pd Subfamily PTPMT1 292-405 3.5e-17 57.4 In-house 56-166 (171) alignment
Range on Protein: 292-405
Range on HMM: 56-166/171.0
NLKITHILNVSTECANAfpkSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAA
. ..... | . |  .      |.||... |   .    .||.. .|. . ...| ||.|||  |..||.|  ...||  . .....|...||..|.|  
eyelkalansteewkkl...gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiir

PNRGFLIQLSKFEQ
 ..  . .|...|.
lakkqwkalqeyee

0050432 (Phosphotyrosine protein) phosphatases II 294-393 1.1e-06 23.7 In-house 132-284 (308) alignment
Range on Protein: 294-393
Range on HMM: 132-284/308.0
KITHILNVSTECANAFPKSFEYLQVKVE-------------------------------------------------DESTEHIGPHLERAAKFVASAIn
....|  . ..  |  .| ..|   ...                                                 | .. .   .| .  ..| . . 
nvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.

SGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPN
.|| . |||  | .|. |  .. |.       .|... .|  .|. .|  . ..
pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt

0047943 (Phosphotyrosine protein) phosphatases II 295-400 5e-10 34.8 In-house 102-264 (273) alignment
Range on Protein: 295-400
Range on HMM: 102-264/273.0
ITHILNVSTECANAFPKSFEYLQVK-------------------------------------------------VEDESTEHIGPHLERAAKFVASAIN-
...|  . ..  .  .| . |   .                                                   | .. .   .| .  ..| .|.. 
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--SGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQL
  |.| | |||. |..|. |  ...|.      ..|.....|  .|...|  . ..  ....|
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl

subfamily_Laforin_pd Subfamily Laforin 313-413 1e-09 31.5 In-house 77-177 (183) alignment
Range on Protein: 313-413
Range on HMM: 77-177/183.0
FEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGKVI
. |. . .|| |||     | .|  .. . .. | .|.|||  |  ||..    ||.   ||.|.    .|  .| ..  .   ||.  |     ||.| 
layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyideealiraekdfiqkfgqvk

S
|
s

0046845 (Phosphotyrosine protein) phosphatases II 329-390 2.6e-07 25.8 In-house 184-256 (284) alignment
Range on Protein: 329-390
Range on HMM: 184-256/284.0
GPHLERAAKFVASAIN---SGGRVFVHCVQGKSRSSTCTIAFLMSYR--------GWTLKDAHEYLKDRRSIA
  .| .  ..| ....   .|| . |||  |..|. |  .. |. ..        |... .|  .|...|  .
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm