Gene SpurDSP-Un-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP021_AA protein Get Run
SpurP021_AA_265-411 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 157-242 9.5e-11 34.2 Pfam-A 14-111 (113) alignment 
Range on Protein: 157-242
Range on HMM: 14-111/113.0
MLILDVRDRADYNASHVTTARHSTA------------VDTEHDCLVSQGKLDKFTMVVVYD-QGSTSQTVDPTLSSF-VQRLKDAnvDVLILSGGYDTFH
...||||. ..|...|.. |..                ... ..  |. |||| . ||||. .|  |...  .|  . ...|     .| .| ||.. ..
vvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktvvvycrsgnrsggaaalllalilkelgyk..nvyvLdGGfeawk
subfamily_MKPLT_pd Subfamily MKPLT 167-226 4.8e-19 62.5 In-house 31-90 (164) alignment 
Range on Protein: 167-226
Range on HMM: 31-90/164.0
DYNASHVTTARHSTAVDTEHDCLVSQGKLDKFTMVVVYDQGSTSQTVDPTLSSFVQRLKD
  ||.|.|...........|...|||.|.|.|...|.|.|.......|..||||..|...
lGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraak
subfamily_MKPLV_pd Subfamily MKPLV 167-226 4.8e-19 62.5 In-house 31-90 (164) alignment 
Range on Protein: 167-226
Range on HMM: 31-90/164.0
DYNASHVTTARHSTAVDTEHDCLVSQGKLDKFTMVVVYDQGSTSQTVDPTLSSFVQRLKD
  ||.|.|...........|...|||.|.|.|...|.|.|.......|..||||..|...
lGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraak
0049772 (Phosphotyrosine protein) phosphatases II 238-406 9.8e-29 96.5 In-house 155-272 (314) alignment 
Range on Protein: 238-406
Range on HMM: 155-272/314.0
YdtfhktypflcnsltirseqdrmlhfksypsvvledtlyqgNVKHSKNETVLKnlkithilnvsTEC--ANAFPKS-FEYLQVKVEDeSTEHIGPHLER
.                                         |  . ..   ||           .|.  .. |..  ..||.. |.|  .. .  ....
g.........................................neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfde

AAKFVASAiNSGGRVFVHCVQGKSRSST-CTIAFLMSYRGWTLKDAHEYLKDRRSiAAPNRGFLIQLSKFEQL
. .|. .| . ||.|.|||  ||.|. | ...|.||...|..|..| |... .|. . ||.||. ||  .|. 
flefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi
0039614 (Phosphotyrosine protein) phosphatases II 246-406 5.6e-19 64.1 In-house 20-287 (297) alignment 
Range on Protein: 246-406
Range on HMM: 20-287/297.0
PFLCNSLTIRSEQDRMLHFKSYPSVVLEDTLYQGNVKHSKNETV--------------------------------------------------------
..|.  ..  | .  .|.|....|.. . . ..  .  .||  .                                                        
dlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

-LKNLKITHILNVSTECANAFpKSFEYL-------------------------------------------QVKVEDESTEHIGPHLERAAKFVASAIN-
 ......|.|... ... .   | ..|                                             ..  | .. ..  .| .. ..| .|.. 
mvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--SGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
  .||.| |||. |..|. |  .|.||     ...|.....| ..|. .|. | .. .....| .... 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
subfamily_MKPLT_pd Subfamily MKPLT 247-411 4.7e-93 303.2 In-house 1-164 (164) alignment 
Range on Protein: 247-411
Range on HMM: 1-164/164.0
FLCNSLTIRSEQDRMlHFKSYPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSG
||...|..|.|.|.. ..|.|||||||||||.||.||..||.|||.||||||.|||.|...|||||.|||||||||||.|.....|||||||.|.||.||
fLitdldvrdeeDyk.rikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsG

GRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGKV
|||.|||||||||||..|.|||....|||||.|.||||.||||.|||||||.||.|||.|..|||
GrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGkv
subfamily_MKPLV_pd Subfamily MKPLV 247-411 4.7e-93 303.2 In-house 1-164 (164) alignment 
Range on Protein: 247-411
Range on HMM: 1-164/164.0
FLCNSLTIRSEQDRMlHFKSYPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSG
||...|..|.|.|.. ..|.|||||||||||.||.||..||.|||.||||||.|||.|...|||||.|||||||||||.|.....|||||||.|.||.||
fLitdldvrdeeDyk.rikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsG

GRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGKV
|||.|||||||||||..|.|||....|||||.|.||||.||||.|||||||.||.|||.|..|||
GrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGkv
PTEN_1 260-405 1.1e-27 92.1 In-house 31-189 (196) alignment 
Range on Protein: 260-405
Range on HMM: 31-189/196.0
RMLHFKSYP--SvVLEDTLYQGNVKHS-KNETVLKNLKITHILNVSTECAN---------AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAI--NS
 | .. | |  .  ....||.|..|.  ..   ||  .||...|.| |...         .| . .|||.. .||  .  .  ... ...|  ...  ..
amgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn

GGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
|. | ||| .|..|| |  .|.||.....| ..| |.....|. .||| ... .| ....
gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfa
subfamily_LRR-DSP_pd Subfamily LRR-DSP 261-408 1.7e-31 103.3 In-house 113-259 (263) alignment 
Range on Protein: 261-408
Range on HMM: 113-259/263.0
MLHFKSYPSVVLeDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQV-KVEDESTEHIGPHLERAAKFVASAINSGGrVFVHCVQGKSR
..   | |. .. | |. |  . ..|...||.| .||||   ...   ||| | || . ..||    .|  |.|.   |. .  ..|| |.|||  | ||
itlvssvPdeii.dklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsr

SSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTF
||| .|..|| ..  ..|.| .  . .|.   ||.||. || |.|.  |
sstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
0044763 (Phosphotyrosine protein) phosphatases II 263-407 2e-35 117.4 In-house 18-170 (178) alignment 
Range on Protein: 263-407
Range on HMM: 18-170/178.0
HFKSYPSVVLEDtLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKS---------FEYLQVKVEDESTEHIGPHLERAAKFVASAI-NSGGRVFVH
 .  ..| .|.. || |.  ....   ||.|.||||.|...|. . |.|.         ..||.. ..| ..  .  |.... .|. .|. ..||.|.||
sdyinaseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSiAAPNRGFLIQLSKFEQLT
|  |..|| |. .|.|| ..|..| .| |... ||. . ||.|.| || .||.  
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
subfamily_STYXL1_pd Subfamily STYXL1 263-410 2.8e-30 98.6 In-house 6-156 (157) alignment 
Range on Protein: 263-410
Range on HMM: 6-156/157.0
HFKSYPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTE---CANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSR
..|.||. || . || || |...|... |.||.   .|||..     .. ..  . |...||||   .. ..|..| .|. .  ..|  |.|   .| ||
elktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisr

SSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGK
| .  ||.|| .. .|||.|..|||. ..   |||.|. |||..|.  .|.
saaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllge
subfamily_DSP1_pd Subfamily DSP1 264-406 3.4e-46 151.3 In-house 12-155 (163) alignment 
Range on Protein: 264-406
Range on HMM: 12-155/163.0
FKSY-PSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSST
 | | |.  . | || |  ... |  .||.|.||.|||||.|. |.|.. ||| ..|.||.... |  ..|.. .|. ......|.|..|| .| |||||
lklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsst

CTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
  .|.||. . ..|..|... |.||||  || ||  || ..|. 
lclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk
subfamily_DSP10_pd Subfamily DSP10 264-405 2.4e-36 119.0 In-house 9-151 (159) alignment 
Range on Protein: 264-405
Range on HMM: 9-151/159.0
FKSYPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPK-SFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSST
... | . .   |. |. | ......|..|.||..||| |.. | | . ...| ...|.| |....  . | | .|.  | ..| ||.|||  | |||.|
ietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsat

CTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
 .||.|| ... .|.||... |..|.| .|| .|. || .||.
vviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefek
subfamily_DSP6_pd Subfamily DSP6 265-405 1.9e-34 112.4 In-house 11-152 (158) alignment 
Range on Protein: 265-405
Range on HMM: 11-152/158.0
KSYPSVVLEdTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPK--SFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSST
...|  .|. .|| |. |...|  |||.||| ..||| ..  |.| .  ...|||. .||. .. .  ..  | .|.  | ..   |.|||  | ||| |
aefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

CTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
 |.|.||...  .|.||....|.|.|  .||  |. || .||.
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfer
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 265-405 1.2e-32 106.4 In-house 4-145 (148) alignment 
Range on Protein: 265-405
Range on HMM: 4-145/148.0
KSYPSVVLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFP-KSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTC
. .|| . .  |. |. |.  .  .||.| .|.| | . |. ||.  .. |||.|...|.  | .    | ...||  | . |.|| ||.  | |||| .
rtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssal

TIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
....|. ..  .||.| .. |..|    || ||| || ..||
allwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
0045098 (Phosphotyrosine protein) phosphatases II 265-407 1.5e-23 79.0 In-house 19-271 (278) alignment 
Range on Protein: 265-407
Range on HMM: 19-271/278.0
KSYPsVVLEDTLYQGNVK-----------------------------------------HSKNETVLKNLKITHILNVSTE-------------------
 ..|    .. || ||..                                         ....   |..|.||.|... ..                   
lgip.seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

---------------------------------CANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAIN--------------SGGRVFVHCVQGK
                                 . ... . . || .   .  ...|  .. .. .|. .|..              |||.|.|||  |.
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSSTCTIAFLMSYR---GWTLKDAHEYLKDRRSI-AAPNRGFLIQLSKFEQLT
.|. |  .|.|| ..   |..| .| ..|. .| . | .| .....| .|... 
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
0051429 (Phosphotyrosine protein) phosphatases II 266-408 6.2e-18 60.9 In-house 14-225 (272) alignment 
Range on Protein: 266-408
Range on HMM: 14-225/272.0
SYPSVVLEDTLYQGNVK---HSKNETVLKNLKITHILNVSTECANAFPK------SFEYLQVKVEDESTEHIG---------------------------
 | .||....|| ..       ..   ||.|.|..|... .|.  .. |       ..||.. ..|.|.. |                            
gygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltll

------------------------PHLERAAKFVASainsGGRVFVHCVQGKSRSSTCTIAFLMSyRGWT--------------LKDAHEYLKDRRSIAA
                          | .. .....    ||.| |||  ||.|. |   ..|.  .|..              | .| |.|...|  | 
lsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgav

PNRGFLIQLSKFEQLTF
.. .....| ....  .
qteeqylflyeallell
0048076 (Phosphotyrosine protein) phosphatases II 267-406 1.1e-33 111.3 In-house 3-141 (145) alignment 
Range on Protein: 267-406
Range on HMM: 3-141/145.0
YPSVVLEDtLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIA
.|| .|.. || |.. . ..   ||.|.||..||...|. . ... ..||.. ..| ..  .  .|... .|. .|...||.|.|||  |..|. |  .|
wpseilpg.lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

FLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
.|| ..|..| .| |... .|..| || |.|..| .||. 
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 267-405 2.1e-32 107.2 In-house 3-142 (144) alignment 
Range on Protein: 267-405
Range on HMM: 3-142/144.0
YPSVVLEDtLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSF--EYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCT
.|| .|.. || |.. ....   ||.|.||...|...|. ..|.. .  .||.. ..| ..  .  .|... .|. .|...||.|.|||  |..|. |  
npseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

IAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
.|.|| ..|..|..| .... ||..| ||.|.|..| ..|.
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0041856 (Phosphotyrosine protein) phosphatases II 268-411 9.2e-29 95.7 In-house 18-176 (182) alignment 
Range on Protein: 268-411
Range on HMM: 18-176/182.0
PSVVLEDTLYQGNVKH--------------SKNETVLKNLKITHILNVSteCANAFPKSF-----EYLQVKVEDESTEHigphLERAAKFVASAINSGGR
..    . || |. ..               .. . ||.|.||.|.|..  . . .|. .     .||.. ..| ..      |. . .|.  ....||.
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRS--IAAPNRGFLIQLSKFEQLTFGKV
|.|||  |..|. |  .|.|| ..|..| .| .... ||.  .  || .|..||  .| | ..| 
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_MSG5_pd Subfamily MSG5 268-405 1.1e-14 47.9 In-house 26-158 (165) alignment 
Range on Protein: 268-405
Range on HMM: 26-158/165.0
PSVVLEDTLYQgnvkHSkNETVLKNLKITHILNVSTECANA---FPKsFEYLQVKVEDESteHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCT
| .|| . ||     .| . .. . | .  ..||. |  .     |   .|  .. | .|  .|   | | .. . .|   . ...|||  | |||..  
pllvlpeklyl....ys.epklkellsfdlvinvakeindlellvpa.vkyyhiewehds..kivkdlsrltriihaatskrkkilvhcqcglsrsasli

IAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
.|..| | . .|.||.. || .    .|. |...|| ..| 
vayimkyynlslrdaydklksvaddispsiglifqlmewev
PTPc_motif_SM00404 269-405 1.5e-37 123.6 In-house 3-139 (140) alignment 
Range on Protein: 269-405
Range on HMM: 3-139/140.0
SVVLEDtLYQGNVKHSKNETVLKNLKITHILNVSTECAN-AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAF
| .|.. || |. ....|. .||.|.|||..||..|. .    ..|..||....|. .... ..|.....|. .|...||.|.|||  | ||| | .||.
srilph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
||.||...|..| |..|.||.|  || .|. || ..|.
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP19_pd Subfamily DSP19 271-405 3.9e-38 125.2 In-house 14-148 (152) alignment 
Range on Protein: 271-405
Range on HMM: 14-148/152.0
VLEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMS
..|..|| | .   .... ||. ||||||||.|.  |.||| |.||.... |.. ...  .|..| .|. .| .. |.|.|||  | |||..  ||.||.
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

YRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
 .  .|..| |.... |  . || ||. || ..|.
keelsleealelvrearpcikPneGFikqLkeyea
subfamily_Slingshot_pd Subfamily Slingshot 272-406 4.3e-33 108.1 In-house 22-156 (169) alignment 
Range on Protein: 272-406
Range on HMM: 22-156/169.0
LEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSY
. | .| |    . |   ||. ....||||. |. | ||..||||...| ||..... .. ... ||.  | ..| .|.|||  | |||..  ||. |  
ifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamke

RGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
 |..|..|.||.|.|||.. ||.||| ||...| .
yglsleealeyvkerrsvikPnkgflkqleeyeGi
0049260 (Phosphotyrosine protein) phosphatases II 272-406 3.3e-25 84.0 In-house 11-148 (152) alignment 
Range on Protein: 272-406
Range on HMM: 11-148/152.0
LEDTLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPK---SFEYLQVKVEDESTEHIGPHLERAAKFVAS-AINSGGRVFVHCVQGKSRSSTCTIAF
   |.. |.  ....   ||.|.||.|... ... ....|    ..||.. ..| ..  .  .|. . .|.   |...||.|.|||. |..|. |  .|.
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

LMSyRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
||  .|..|..| .... .|..| || |.|..| .||.|
lml.lgvsleeavalvrekRpgavpnpgqlrflyefekl
0051082 (Phosphotyrosine protein) phosphatases II 272-400 2.4e-20 68.1 In-house 11-146 (151) alignment 
Range on Protein: 272-400
Range on HMM: 11-146/151.0
LEDTLYQGNVKHSKNETVLKNLKITHILNVST-----ECANAFPK-SFEYLQVKVEDESTEHIGPHLERAAKFVASAINS-GGRVFVHCVQGKSRSSTCT
... || ..  .. .   ||.|.|..|.|. .      |.. .|. ..|.|.. ..| ..  .  ... ...|.  ...  .| |.|||  ||.|. |  
vtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

IAFLMSyRGWTLKDAHEYLKDRRS-IAAPNRGFLIQL
...||  .|..| .| |... .|  .  || .||.||
alylml.lgvsleealeeyrlkrpgvvqpnqqflfql
subfamily_DSP12_pd Subfamily DSP12 273-407 6.2e-32 105.1 In-house 6-143 (155) alignment 
Range on Protein: 273-407
Range on HMM: 6-143/155.0
EDTLYQGNVKHSKNETVLKNLKITHILNVSTECA---NAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLM
.. || |.... ..|. ||.|||||.| | .|     .. ..  ....... || .| |  ||..| .|. .|.. .| |.|||  | |||.|  ||.||
lpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlm

SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLT
 . .. |..|.. .|. .. . || ||| ||  ||.. 
kkeklslekAlklvkekkpeiepNegFleQLklfekmg
0046846 (Phosphotyrosine protein) phosphatases II 273-408 1.2e-25 85.7 In-house 16-173 (176) alignment 
Range on Protein: 273-408
Range on HMM: 16-173/176.0
EDTLYQGNVK----------HSKNETVLKNLKITHILNVSTEC-------ANAFPK----SFEYLQVKVEDESTEHIgPHLERAAKFVASAINSGGRVFV
 . |. |.            . ..   ||.|.||...|. .|        .| .|     ...||.. ..| ..  .  .|... .|. .|...||.| |
nanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlV

HCVQGKSRSSTCTIAFLMSY-RGWTLKDAHEYLKDRRS-IAAPNRGFLIQLSKFEQLTF
||. |..|. |  .|.|. . .|... .| ......|.  | ...... .| .||.| .
HCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0036282 (Phosphotyrosine protein) phosphatases II 273-407 2.2e-22 75.0 In-house 16-169 (174) alignment 
Range on Protein: 273-407
Range on HMM: 16-169/174.0
EDTLYQGNVKHSkNETVLKNLKITHILNVSTECANA---------------FPKSFEYLQVKVEDESTEHIGPhLERAAKFVASAINS--GGRVFVHCVQ
 . |. |.. .. .   ||.|.||..... .|. .                 .  ..||.. ..| ..  .   |... ||| .|...  || | |||  
tprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsa

GKSRSSTCTIAFLMSYRGW-TLKDAHEYLKDRR---SIAAPNRGFLIQLSKFEQLT
|..|. |  .|.|| .... .| || .... .|   . . .. .....| .||.| 
GvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
subfamily_DSP14_pd Subfamily DSP14 274-411 2.1e-39 129.0 In-house 12-148 (157) alignment 
Range on Protein: 274-411
Range on HMM: 12-148/157.0
DTLYQGnVKHSKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRG
..|. .    ......||. |||.|.||..|  |   |..|...|.|||...... .|....|. . .. ..||.. |||| | ||| . ..|.|| |. 
psLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyek

WTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGKV
 .|..|....|..|.|  || ||  || ..|.  .||.
lsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
subfamily_DSP3_pd Subfamily DSP3 274-404 3.2e-31 102.2 In-house 16-154 (162) alignment 
Range on Protein: 274-404
Range on HMM: 16-154/162.0
DTLYQGNVKHSKNETVLKNLKITHILNVSTEC------ANAFP--KSFEYLQVKVEDESTEHIGPHLERAAKFVASAINS-GGRVFVHCVQGKSRSSTCT
..|| |. . .|... ||.| |||.|| .          . |    ...|| ..|.|  . ..  . |.||||...|...  |.|.||||.| |||.|. 
pklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlv

IAFLMSYRGWTLKDAHEYLKDRRSIaAPNRGFLIQLSKFE
.|.|| .|  ||..| .  ...|.|  ||.||| || ...
layLmirrkmtlveairtvrkkRei.lPneGFlkqLaeld
subfamily_DSP8_pd Subfamily DSP8 274-405 3e-28 92.4 In-house 20-152 (159) alignment 
Range on Protein: 274-405
Range on HMM: 20-152/159.0
DTLYQGNVKHSKNETVLKNLKITHILNVSTECAN-AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYR
. || |  |.. .|..|..| |...||.|..| .  . |  ..|.| |.|. .|.. | .... .|.  | .. |||.||.  |.|||.|  ||..| . 
knlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktl

GWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
  .| .|....|..|    ||  || || ..|.
emsldeayrfvkekrptispnlnflgqLleyek
0043147 (Phosphotyrosine protein) phosphatases II 274-407 1.6e-27 91.7 In-house 24-160 (172) alignment 
Range on Protein: 274-407
Range on HMM: 24-160/172.0
DTLYQGNVKHSKNETVLKNLKITHILNVSTE---CANAFPKSFEYLQVKVEDESTEhIGPHLERAAKFVAS--AINSGGRVFVHCVQGKSRSSTCTIAFL
.|.. ..  ....   ||.|.||||.|. ..   . . ..  ..|| . ..| ..  .  .|... .|. .  |...||.| |||. |..|. |  .|.|
atqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaayl

MSyRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLT
|  .|..| .| ......|..| .| .....| .||.| 
ml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0037934 (Phosphotyrosine protein) phosphatases II 274-405 2.7e-22 74.9 In-house 44-239 (243) alignment 
Range on Protein: 274-405
Range on HMM: 44-239/243.0
DTLYQGNV--------KHSKNETVLKNLKITHILNVSTEC---------------------------------------------ANAFPKSFEYLQVKV
..|. ...        .. ..   |..|.||.|... ...                                              . .   . |... .
prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpw

ED----ESTEHIGPHLERAAKFVAS-----AINSGGRVFVHCVQGKSRSSTCTIAFLMSYR-GWTLKDAHEYLKDRRSI-AAPNRGFLIQLSKFEQ
 |    .|.|..  .|. . .|. .     |..|||.| |||. |..|. |  .|.|| .. |..| .| ..|...|.  | ........| ....
pdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_DSP15_pd Subfamily DSP15 275-407 3.2e-32 105.7 In-house 8-139 (151) alignment 
Range on Protein: 275-407
Range on HMM: 8-139/151.0
TLYQGNVKHSKNETVLKNLKITHILNVSTeCANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGW
 || ||.. ||.|. ||. .|||||.|.   |. . | .||. ....| .  ..  ... . .|. ..   .. |.|||. | ||| | ..|.||.    
glylgnfrdskdeelLkeknithilsvhd.nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtel

TLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLT
  .|| | .| .||.| || ||  || ..|. .
nwrdalevikaaRsvanPnfGfkrqlkeyektk
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 275-405 1.7e-26 86.4 In-house 9-150 (154) alignment 
Range on Protein: 275-405
Range on HMM: 9-150/154.0
TLYQGNVKHSKNETVLKNLKITHILNVSTECANAFPKS---------FEYLQVKVEDESTEHIGPHLERAAKFVASAI--NSGGRVFVHCVQGKSRSSTC
 || .  . . |   |.. .|..||||..   |.|..          .|||.... |.   .|  .|..| .|. .||     ..|.||. .| |||.. 
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
 |..||  .  .|  | | ||| | |  ||.||| || .||.
lisylmdklkislslalellkdsryiikPnqGflkqleifek
DSPc Dual specificity phosphatase, catalytic domain 276-405 2.3e-36 119.6 Pfam-A 1-132 (133) alignment 
Range on Protein: 276-405
Range on HMM: 1-132/133.0
LYQGNVKHSKnETVLKNLKITHILNVSTECAN---AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYR
|| |. .... ...|..|.||...||..|. |     ....|||...||||... | ..||.| .|...|...|..|.|||  | ||| | .||.||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
...|..| |..|.|||.  || ||| || ..|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 276-405 2.3e-36 119.6 In-house 1-132 (133) alignment 
Range on Protein: 276-405
Range on HMM: 1-132/133.0
LYQGNVKHSKnETVLKNLKITHILNVSTECAN---AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYR
|| |. .... ...|..|.||...||..|. |     ....|||...||||... | ..||.| .|...|...|..|.|||  | ||| | .||.||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
...|..| |..|.|||.  || ||| || ..|.
nlslneAyefvkerrskispnagflrqLleyer
0042113 (Phosphotyrosine protein) phosphatases II 276-405 2.1e-20 68.6 In-house 54-240 (245) alignment 
Range on Protein: 276-405
Range on HMM: 54-240/245.0
LYQGNVKHSKNET----VLKNLKITHILNVSTECANAFPKSFE----------------------------------------------YLQVKVEDEST
.. ..  ....       |..|.||.|.....|  . ..|...                                              |... ..| ..
fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgv

EHIGPHLERAAKFVASAIN--SGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
 ..  .|... .|| .|..  |.|.|.|||  |..|. |  .|.||     ...|..| .| ..|...|. | .. .....| ....
pdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 276-404 2.8e-20 65.9 In-house 6-138 (145) alignment 
Range on Protein: 276-404
Range on HMM: 6-138/145.0
LYQGNVKHSKNETVLKNLKITHILNVSTE----CANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSY
|| | . |... ..|..| |. |.|...     . ..  .|.| | .  ||  .  .  |..  . |.    . |  |||||. | ||| | ..|||| |
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

RGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFE
 . || .|   .. .|  | ||  || .| ..|
cnmtlseaarqvrsnrllaypnvtflknllnle
0045450 (Phosphotyrosine protein) phosphatases II 281-405 1.6e-20 69.5 In-house 102-301 (307) alignment 
Range on Protein: 281-405
Range on HMM: 102-301/307.0
VKHSKNE----------------TVLKNLKITHILNVSTECANAF-------PKS---------------------FEYLQVKVEDE-------------
. ..|..                  |.....|.|....... ...       | .                     . .....|.|              
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfh

----STEHIGPHLERAAKFVASAIN------SGGRVFVHCVQGKSRSSTCTIAFLMSYRG--------WTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQ
       .. |..| . .|.  . .      .||.| |||  |..|. |  .|.|| ...        ..| .| ..|...|. | .| .....| ....
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
subfamily_STYX_pd Subfamily STYX 283-410 4.2e-23 75.2 In-house 29-160 (166) alignment 
Range on Protein: 283-410
Range on HMM: 29-160/166.0
HSKNEtVLKNLKITHILNVSTEC-----ANAFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLK
.|| | |||.  ||||. .  .         ||..| || . | |...| |  .| .  .|. .....||.|.||   | |||..  ||..|   |   .
kskle.vlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyr

DAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGK
.|. |...||   .|| ||  || ..| . . |
eafayvqerrfcinpnegfvsqlkeyeaiylak
0038934 (Phosphotyrosine protein) phosphatases II 284-408 1.6e-17 59.2 In-house 46-177 (194) alignment 
Range on Protein: 284-408
Range on HMM: 46-177/194.0
SKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKVEDESTEHIG--PHLERAAKFVASA-----INSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTL
  .   |.| |........ .     |. || . ... .  ..  |  | ||   .|.  .      ..|| | |||. |..|. |  .|.|. ..|...
lvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsa

KDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTF
..| ......|  | ||...| .| |. . ..
eeAialfrekRpgaipnqdyleallkrykelr
0051299 (Phosphotyrosine protein) phosphatases II 284-393 2.5e-08 29.2 In-house 153-271 (288) alignment 
Range on Protein: 284-393
Range on HMM: 153-271/288.0
SKNETVLKNLKITHILNVSTECANAFPKSFEYLQVKV----EDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGW
 ..|.||.. .....  . ..  .   .|... .  .    ..   ... . |.   ..  .  ..|| | |||  |..|. |  ...|.       .|.
llseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggv

TLKDAHEYLKDRRSIAAPN
.. .| ..|. .|  . ..
dvleavkrlreqRpgmvqt
0036941 (Phosphotyrosine protein) phosphatases II 285-407 4.7e-16 54.4 In-house 35-276 (297) alignment 
Range on Protein: 285-407
Range on HMM: 35-276/297.0
KNET----------------------------------------------------------VLKNLKITHILNVSTECANAFPKSFEYLQVK-------
...                                                            . ....|.|......  . ..| ..|   .       
llpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslty

------VEDES----------------------------------TEHIGPHLERAAKFVASAIN------SGGRVFVHCVQGKSRSSTCTIAFLM----
      . ...                                    .. .. .   .|.  . .      |||.| |||. |..|| |  .|.||    
gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqql

----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLT
     ..|.....|  .|...|  | .. .....|  ...  
edklkeggvdileavkklReqRpgavqtleqyrflyeallel
0040439 (Phosphotyrosine protein) phosphatases II 288-406 3.7e-22 74.6 In-house 72-244 (249) alignment 
Range on Protein: 288-406
Range on HMM: 72-244/249.0
TVLKNLKITHILNVSTECAN-------------------------------------------AFPKSFEYLQVKVEDESTEHIGPHLERAAKFVASAIN
  |..|.||.|....... .                                            ...|...|.. . |    .. |..| . .|.  . .
rmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrk

------SGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQL
      .||.|.|||  |..|. |  .|.||      ..|..|..| ..|...|. | .| .....| .... 
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 288-408 2.5e-17 58.6 In-house 49-276 (317) alignment 
Range on Protein: 288-408
Range on HMM: 49-276/317.0
T-------------------------------------------------------VLKNLKITHILNVSTECANA------------------------
                                                         ......|.|... ... .                         
ypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtll

---FPKSFEYLQVKVEDE----------------STEHIGPHLERAAKFVASAINS----GGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAH
     .........|||                    .. |...   .|.  . ..    || | |||. |..|. |  .|.||      ..|.....| 
seeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeav

EYLKDRRSIAAPNRGFLIQLSKFEQLTF
..|. .|. | .. .....| ....  .
kelreqRpgavqtpeqyrflydalleyl
0043336 (Phosphotyrosine protein) phosphatases II 289-404 3.2e-14 48.5 In-house 107-273 (278) alignment 
Range on Protein: 289-404
Range on HMM: 107-273/278.0
VLKNLKITHILNVSTECANAFPKSFEYL----------------------------QVKVEDESTE------------------HIGPHLERAAKFVASA
 ...|..|.|... ..  .  .|...|                              |.   .. .                  .. ..|.   ..    
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

INSGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFE
 .|.| | |||. |..|. |  ...|.     ...|..| .| ..|. .|  | ..  ....| ...
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_PTPMT1_pd Subfamily PTPMT1 292-405 3.5e-17 57.4 In-house 56-166 (171) alignment 
Range on Protein: 292-405
Range on HMM: 56-166/171.0
NLKITHILNVSTECANAfpkSFEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAA
. ..... | . |  .      |.||... |   .    .||.. .|. . ...| ||.|||  |..||.|  ...||  . .....|...||..|.|  
eyelkalansteewkkl...gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiir

PNRGFLIQLSKFEQ
 ..  . .|...|.
lakkqwkalqeyee
0050432 (Phosphotyrosine protein) phosphatases II 294-393 1.1e-06 23.7 In-house 132-284 (308) alignment 
Range on Protein: 294-393
Range on HMM: 132-284/308.0
KITHILNVSTECANAFPKSFEYLQVKVE-------------------------------------------------DESTEHIGPHLERAAKFVASAIn
....|  . ..  |  .| ..|   ...                                                 | .. .   .| .  ..| . . 
nvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.

SGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPN
.|| . |||  | .|. |  .. |.       .|... .|  .|. .|  . ..
pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
0047943 (Phosphotyrosine protein) phosphatases II 295-400 5e-10 34.8 In-house 102-264 (273) alignment 
Range on Protein: 295-400
Range on HMM: 102-264/273.0
ITHILNVSTECANAFPKSFEYLQVK-------------------------------------------------VEDESTEHIGPHLERAAKFVASAIN-
...|  . ..  .  .| . |   .                                                   | .. .   .| .  ..| .|.. 
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--SGGRVFVHCVQGKSRSSTCTIAFLM-----SYRGWTLKDAHEYLKDRRSIAAPNRGFLIQL
  |.| | |||. |..|. |  ...|.      ..|.....|  .|...|  . ..  ....|
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
subfamily_Laforin_pd Subfamily Laforin 313-413 1e-09 31.5 In-house 77-177 (183) alignment 
Range on Protein: 313-413
Range on HMM: 77-177/183.0
FEYLQVKVEDESTEHIGPHLERAAKFVASAINSGGRVFVHCVQGKSRSSTCTIAFLMSYRGWTLKDAHEYLKDRRSIAAPNRGFLIQLSKFEQLTFGKVI
. |. . .|| |||     | .|  .. . .. | .|.|||  |  ||..    ||.   ||.|.    .|  .| ..  .   ||.  |     ||.| 
layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyideealiraekdfiqkfgqvk

S
|
s
0046845 (Phosphotyrosine protein) phosphatases II 329-390 2.6e-07 25.8 In-house 184-256 (284) alignment 
Range on Protein: 329-390
Range on HMM: 184-256/284.0
GPHLERAAKFVASAIN---SGGRVFVHCVQGKSRSSTCTIAFLMSYR--------GWTLKDAHEYLKDRRSIA
  .| .  ..| ....   .|| . |||  |..|. |  .. |. ..        |... .|  .|...|  .
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm