Gene PRL in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP022_AA protein Get Run
SpurP022_AA_8-161 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 2-154 6.4e-31 103.6 In-house 90-299 (307) alignment 
Range on Protein: 2-154
Range on HMM: 90-299/307.0
SSIRSVRPAPVEIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYDAAV------------------------------------------
| .|  ....... .. ..|..  .| .. ||.|.. |.. ... .|...|..... .                                          
syvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdld

LKQEDIEVMDMPF---DDGGVPS-SEIIDQWLALLKMRFKET-PKSCVAVHCVAGLGRAPLMVALALMEAG---------MTYEDAVEFVREKRRGAI-N
 ..| ..|. ...    |.|||.  |.. ... ...  ..|. ....|.||| ||.||.. ..|. ||  .         .....||...||.| ||. |
gtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn

AKQLHFLERY
  |..|| ..
peqyrflyea
subfamily_PRL_pd Subfamily PRL 11-159 8.8e-78 253.6 In-house 2-150 (151) alignment 
Range on Protein: 11-159
Range on HMM: 2-150/151.0
PVEIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYDAAVLKQEDIEVMDMPFDDGGVPSSEIIDQWLALLKMRFKETPKSCVAVHCVAGL
.||| .|.|||||...|... .|.||.|||....|.||||||||||...|..|.|||.|..||||.||..|....||.|||..|||.|||.|||||||||
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGl

GRAPLMVALALMEAGMTYEDAVEFVREKRRGAINAKQLHFLERYKPRLR
||||..|||||.||||.|||||||.|||||||||.|||.|||.||.. .
GraPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk
0043147 (Phosphotyrosine protein) phosphatases II 11-158 7.2e-38 125.4 In-house 12-160 (172) alignment 
Range on Protein: 11-158
Range on HMM: 12-160/172.0
PVEIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYDAAVLKQEDIEVMDMPFDDGGVPSSEIIDQWLALLKMRFKETPKSCVAVHCVAGL
....... .||.. . |  | ...|.. ||...|. .|...| .||.  |....|... .|..|.|||..|.....| ... .. . |. .|.|||.||.
yldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGv

GRAPLMVALALMEAGMTYEDAVEFVREKRRGAI-NAKQLHFLERYKPRL
||....||. ||. |...|.||..|||||.||. |  |..||  .  .|
gRtgtlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyfekll
0036282 (Phosphotyrosine protein) phosphatases II 11-154 1.4e-29 98.4 In-house 9-165 (174) alignment 
Range on Protein: 11-154
Range on HMM: 9-165/174.0
PVEIVHKHMRFLIIHNPDKngvehFIQELKQRQIKEVVRVCEPTYDA------------AVLKQEDIEVMDMPFDDGGVPSSEIIDQWLALLKMRFKETP
|. ...   |...   | .     |...||. .|. ||...|. ..               |....|.....|..|.|||...|..... ...  ..| |
pldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedp

KSCVAVHCVAGLGRAPLMVALALMEAGM--TYEDAVEFVREKR----RGAINAKQLHFLERY
. .|.||| ||.||....||. ||. |.  ...||...|||.|    .. ..  |..||  .
ggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0042113 (Phosphotyrosine protein) phosphatases II 12-154 5e-29 96.8 In-house 45-238 (245) alignment 
Range on Protein: 12-154
Range on HMM: 45-238/245.0
VEIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYD-------------------------------------------AAVLKQEDIEVM
|   .   .|..   | .. ||.|.. |.. .|. .|...|....                                               ..|.| ..
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

DMPFDDGGVPS-SEIIDQWLALLKMRFKETPKSCVAVHCVAGLGRAPLMVALALM------EAGMTYEDAVEFVREKRRGAI-NAKQLHFLERY
 .|..|.|||. .|.....| ...   .|...  |.||| ||.||. ...|. ||      | |.. |.||...|..|.||. .  |..|| ..
ylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 12-154 1.3e-28 95.7 In-house 47-241 (249) alignment 
Range on Protein: 12-154
Range on HMM: 47-241/249.0
VEIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPT---------------------------------------------YDAAVLKQEDIE
..  .  .||..   | .. ||.|.. |.. .|. .|......                                             ||  ...   | 
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

VMDMPfDDGGVPSSEIIDQWLALLKMRFKET-PKSCVAVHCVAGLGRAPLMVALALM------EAGMTYEDAVEFVREKRRGAI-NAKQLHFLERY
. |.| |.|  || |...... ...  ..|. ....|.||| ||.||.....|. ||      | |...|.||...|..|.||. |  |. || ..
ytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 12-154 2.6e-27 91.4 In-house 79-271 (317) alignment 
Range on Protein: 12-154
Range on HMM: 79-271/317.0
VEIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYD------------------------AAVLKQEDIEVMDMPF---------------
|.. .. ..|..   | .| ||.|.. ... ... .|...|....                          . . ..|..  ...               
vdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfh

----DDGGVP-SSEIIDQWLALLKMRFKeTPKSCVAVHCVAGLGRAPLMVALALM------EAGMTYEDAVEFVREKRRGAI-NAKQLHFLERY
    .|.||| | ... ..| ...  ..  |...|.|||.||.||.  ..|. ||      | |...|.||...||.|.||. .  |..|| ..
ytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0043336 (Phosphotyrosine protein) phosphatases II 12-153 1.5e-25 85.7 In-house 81-271 (278) alignment 
Range on Protein: 12-153
Range on HMM: 81-271/278.0
VEIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPT--------------------------------------------YDAAVLKQEDIEV
|.  .. ..|..   | .. ||.|.. ... ... .|...|..                                            .|  ...   .  
vdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhy

MDMPfdDGGVP-SSEIIDQWLALLKMRFKeTPKSCVAVHCVAGLGRAPLMVALALM------EAGMTYEDAVEFVREKRRGAI-NAKQLHFLER
...|  |.||| | ... ..|  .. ... .....|.|||.||.||. ...|| |.      | |...|.||...||.| ||. .  |..|| .
lgwp..dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0047943 (Phosphotyrosine protein) phosphatases II 12-151 1.1e-23 79.5 In-house 70-264 (273) alignment 
Range on Protein: 12-151
Range on HMM: 70-264/273.0
VEIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYDAA--------------VLKQEDIEVM-----------------------------
|.  .. ..|..  .| .| ||.|.. ... ... .|...|....                .|. ... |                              
vdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvt

---DMPFDDGGVP-SSEIIDQWLALLKMRFKET-PKSCVAVHCVAGLGRAPLMVALALM------EAGMTYEDAVEFVREKRRGAI-NAKQLHFL
    ... | ||| | |.. ... |..  ....  .. |.|||.||.||.  ..|| |.      | |.....|| ..|..| |.. .  |. ||
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 12-146 1.3e-20 69.5 In-house 85-272 (288) alignment 
Range on Protein: 12-146
Range on HMM: 85-272/288.0
VEIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPT-------------------------------------------------YDAAVLKQ
... .. ..|..   | .| ||.| . . . ... .|......                                                 .|  ... 
idgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtv

EDIEVMDMPfdDGGVPS-SEIIDQWLALLKMRFKeTPKSCVAVHCVAGLGRAPLMVALALM------EAGMTYEDAVEFVREKRRGAINAK
  . ... |  | |||.  | . ..| |..  ..  ....|.||| ||.||.  ..|| |.      | |.....||...||.| |...  
thfhytnwp..dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 12-151 3.8e-19 64.5 In-house 71-269 (297) alignment 
Range on Protein: 12-151
Range on HMM: 71-269/297.0
VEIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYD---------------------------------AAVLKQEDIEVMD---------
|.. .  ..|.. . | .| ||.| . . . ... .| ..|.. .                                  .  ..  .|| |         
vdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtv

-----MPFDDGGVP--SSEIIDQWLALLKMRFKETPKSCVAVHCVAGLGRAPLMVALAL---------MEAGMTYEDAVEFVREKRRGAINAK-QLHFL
     .  .| |||   ....| . ...|.. . .... | |||.||.||.  ..|. |         .| |... .|| ..||.| ||.    |..||
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl
0049260 (Phosphotyrosine protein) phosphatases II 13-154 1.6e-35 117.4 In-house 3-145 (152) alignment 
Range on Protein: 13-154
Range on HMM: 3-145/152.0
EIVHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYDAAVLKQEDIEVMDMPFDDGGVPSSEIIDQWLALLKMRFKETPKSCVAVHCVAGLGR
........|.. . |  | ...|.. ||. .|. .|...|..... .   . |... .|..|.|||..... ..| |.  .... .. .|.|||.||.||
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgR

APLMVALALMEAGMTYEDAVEFVREKRRGAI-NAKQLHFLERY
....||. ||. |...|.||..||||| ||. |  || ||  .
tgtlvaaylmllgvsleeavalvrekRpgavpnpgqlrflyef
0045098 (Phosphotyrosine protein) phosphatases II 15-160 3.9e-31 103.9 In-house 62-273 (278) alignment 
Range on Protein: 15-160
Range on HMM: 62-273/278.0
VhkHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYDA----------------------------------------------AVLKQEDIEVM
   ...|..   | .. |..|.. |.. .|. .|...| ....                                              . |..  ....
y..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthl

DM-PFDDGGVPSSEIIDQWLALLKMRFK---------------ETPKSCVAVHCVAGLGRAPLMVALALMEA----GMTYEDAVEFVREKRRG-AI-NAK
.. |..|.||||..|....| ||..  .               . .. .|.||| ||.||.  .||. ||      |.....||...|..|.| |. |  
hylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnle

QLHFLERYKPRLRM
|..||...  .|..
qyrflyefllelll
0039614 (Phosphotyrosine protein) phosphatases II 15-158 2.4e-28 94.9 In-house 96-288 (297) alignment 
Range on Protein: 15-158
Range on HMM: 96-288/297.0
VHK-HMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYD----------------------AAVLKQEDIE-----------------VMDMPFDD
 ..  ..|..   | .. ||.|.. ... ... .|........                        | . ...                  .  ... |
ydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpd

GGVP-SSEIIDQWLALLKMRFKET-PKSCVAVHCVAGLGRAPLMVALALM------EAGMTYEDAVEFVREKRRGAI-NAKQLHFLERYKPRL
.||| |.|.....| |.. ...|. .. .|.|||.||.||.  ..|. ||      | |.....||...||.|.||. .  |..|| ..   |
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0050432 (Phosphotyrosine protein) phosphatases II 15-147 5.1e-22 74.0 In-house 102-286 (308) alignment 
Range on Protein: 15-147
Range on HMM: 102-286/308.0
V--HKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYDA--------------AVLKQEDIEV-------------------------------
   .. ..|..   | .| ||.|.. . . ... .|........                .|. ... |                               
yssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvth

---MDMPfdDGGVPSSeiIDQWLALLKMRFKETPKSCVAVHCVAGLGRAPLMVALALM------EAGMTYEDAVEFVREKRRGAINAKQ
   .. |  |.|||.|  ... |..|..  |  |.. ..||| ||.||.  ..|| |.      | |.....|| ..||.| |... ..
fhytnWp..dhgvPps..peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 15-146 1.8e-19 65.7 In-house 73-260 (284) alignment 
Range on Protein: 15-146
Range on HMM: 73-260/284.0
VHKHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTY-----------------------------------------------DAAVLKQEDIEV
......|..   | .| ||.| . . . ... .| ..|..                                                .  ...   . .
tyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhy

MDMPfdDGGVP-SSEIIDQWLALLKMRFKE-TPKSCVAVHCVAGLGRAPLMVALALMEA---------GMTYEDAVEFVREKRRGAINAK
.. |  | ||| |.|.. ..| |..  ...  ... ..||| ||.||.  ..|| |.           |.....|| ..||.| |...  
tswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0041856 (Phosphotyrosine protein) phosphatases II 17-163 3.5e-31 103.6 In-house 32-174 (182) alignment 
Range on Protein: 17-163
Range on HMM: 32-174/182.0
KHMRFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEPTYDAAVLKQEDIEVMDMPFDDGGVPSseiIDQWLALLKMRFKetPKSCVAVHCVAGLGRAPLM
...||.. . | .. |..|.. ||...|. .|...|. |..  |... |.....|..|.|||.   .|..|.....  .  .. .|.||| ||.||.. .
patrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle..eggpvlVHCsaGvgRtgtl

VALALME-AGMTYEDAVEFVREKRRGAINAKQLHFLERYKPRLRMKAK
||. ||.  |...|.||..||..| |..   . .|..... ..... |
vaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
0038934 (Phosphotyrosine protein) phosphatases II 20-160 3.8e-36 119.9 In-house 19-175 (194) alignment 
Range on Protein: 20-160
Range on HMM: 19-175/194.0
RFLIIHNPDKNGVEHFIQELKQRQIKEVVRVC----------------EPTYDAAVLKQEDIEVMDMPFDD-GGVPSSEIIDQWLALLKMRFKETPKSCV
||.... | .. ....|.||..  .. .||..                |..||.  ... .||....|| | | ||| ||....| |..  ..| |. .|
rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv

AVHCVAGLGRAPLMVALALME-AGMTYEDAVEFVREKRRGAInaKQLHFLERYKPRLRM
||||.|||||....|| .|..  ||..|.|....||||.|||   . ..|| .  | ..
aVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyleallkryke
0046846 (Phosphotyrosine protein) phosphatases II 20-159 1.1e-33 111.8 In-house 24-173 (176) alignment 
Range on Protein: 20-159
Range on HMM: 24-173/176.0
RFLIIHNPDKNGVEHFIQELKQRQIKEVVRVCEP--------TYDAAVLKQEDIEVMDMPFDDGGVPSSEIIDQWLALLKMRFKETpkSCVAVHCVAGLG
|... . |  . ...|...||. .|. ||...|.        ...  .|....|... .|..|.|||..|.....|.... . ||    .|.|||.||.|
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGig

RAPLMVALALMEA--GMTYEDAVEFVREKRR-GAI-NAKQLHFLERYKPRLR
|....||. |.|   |...|.|...|||.|. ||. . .|..||...  .|.
RtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
0037934 (Phosphotyrosine protein) phosphatases II 20-154 1.1e-26 89.3 In-house 45-237 (243) alignment 
Range on Protein: 20-154
Range on HMM: 45-237/243.0
RFLIIHNPDKNGVEH----FIQELKQRQIKEVVRVCEPT------------------------------------------YDAAVLKQEDIEVMDMPFD
|. .   | .. ||.    |.. |.. .|. .| ..|..                                          .|.  |....| .. .|. 
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

DGGVPS-SEIIDQWLALLKMRFKE-------TPKSCVAVHCVAGLGRAPLMVALALMEA--GMTYEDAVEFVREKRRG-AI-NAKQLHFLERY
|.|||.  |.. ..|  ..   .|        ... |.|||.||.||. ...|. ||    |...|.||...||.| | |. .  |..|| ..
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
subfamily_VSP_pd Subfamily VSP 25-142 4.1e-08 27.4 In-house 58-173 (212) alignment 
Range on Protein: 25-142
Range on HMM: 58-173/212.0
HNPDKNgVEHFIQElKQRQIKEVVRVC-EPTYDAAVLKQEdieVMDMPFDDGGVPSSEIIDQWLALLKMRFKETPKSCVAVHCVAGLGRAPLMVALALME
 || .. |  |... | |.  .|| .| | .|| ......   |. .  ||  ||. | . .    .|  ... .|  .|.||  | ||.  .|   |..
rnpise.varfldt.khrdhykvvnlcseraydekyfnnr...vkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcallla

AGM--TYEDAVEFVREKRRGA
...  | ......  |.|   
seifetakesldyfgerrtdk
0044763 (Phosphotyrosine protein) phosphatases II 28-160 6e-30 99.6 In-house 37-172 (178) alignment 
Range on Protein: 28-160
Range on HMM: 37-172/178.0
DkngvEHFIQELKQRQIKEVVRVCEPTY------DAAVLKQEDIEVMDMPFDDGGVPS-SEIIDQWLALLKMRFKeTPKSCVAVHCVAGLGRAPLMVALA
.    ..... ||.  |. .|...|...      |.  .....|... .|..|.|||. .|..........   . .....|.||| ||.||....||. 
p....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaay

LM-EAGMTYEDAVEFVREKRRGAINAKQLHFLERYKPRLRM
|| . |...|.|.|.|||.|.. .|  ||..|... .||. 
lmkklglsleeaielvrerRpivpnpgqlrqLyefelrllk
0049772 (Phosphotyrosine protein) phosphatases II 29-159 5.9e-24 80.8 In-house 94-274 (314) alignment 
Range on Protein: 29-159
Range on HMM: 94-274/314.0
KNGVEHF--------------------------------------------------------------IQELKqrqikevvrvcEPTYDAAVLKQEDIE
...|. |                                                              ...||           | .||.  .... |.
eitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...........eelydpelferlgik

VMDMPFDDGGVPSSEIIDQWLALLKMRfkeTPKSCVAVHCVAGLGRAP--LMVALALMEAGMTYEDAVEFVREKRRGAINAKQLHFLERYKPRLR
....|..||..|..|..|..|....      ....|.||| || ||..  . .|. ..  |...|.|.|.||.||   .|  ....||.|  .|.
ylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefile
0051429 (Phosphotyrosine protein) phosphatases II 29-155 1.3e-17 59.8 In-house 32-221 (272) alignment 
Range on Protein: 29-155
Range on HMM: 32-221/272.0
KNGVEHFIQElKQRQIKEVVRVCEPTYDA---AVLKQEDIEVMDMPFDDGGVPSSEII------------------------------------------
.. ...| .  |. .|| .| ...... .     .  ..|... .|. | ..|. ...                                          
pltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdw

-------DQWLALLKMRFKetpKSCVAVHCVAGLGRAPLMVALALMEAGMT--------------YEDAVEFVREKRRGAI-NAKQLHFLERYK
       .. |.||..  .   .  | ||| || .|  ..||| |. .|..              .|.||| .|..|.||. .  |..|| .. 
pdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal
subfamily_PTEN_pd Subfamily PTEN 30-140 8.6e-12 40.4 In-house 48-157 (184) alignment 
Range on Protein: 30-140
Range on HMM: 48-157/184.0
NGVEHFIQELKQRQIKeVVRV-CEPTYDAAVLkqeDIEVMDMPFDDGGVPSSEIIDQWLALLKMRFKETPKSCVAVHCVAGLGRAPLMVALALMEAGMTY
. | .|... .. . | .  .  | .||.. .   | .|. .||||   |. |.... .  ... ..| .|  |.||| || ||. ....  |...... 
edvvkflekkhkdhyk.iynlrserkydskkf...dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllksllle

--EDAVEFVREKRR
  |.|.|.  |.| 
kaeealelfaeaRt
PTEN_1 32-158 2.6e-26 87.7 In-house 56-191 (196) alignment 
Range on Protein: 32-158
Range on HMM: 56-191/196.0
VEHFIQELKQRQIKEVVRVCE------PTYDAAVLKQEDIEVMDMPFDDGGVPSSEIIDQWLALLKMRFKETP-KSCVAVHCVAGLGRAPLMVALALMEA
|. . ..||.. |  ||...|      ..||    .....|. ..|..| |.|| . .  ... ..   .. | . .|.||| |||||  ..||  ||..
vaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmyk

G-MTYEDAVEFVREKR-RGAINAKQLHFLERYKPRL
| .|...|.|.||||| .||.|  ..  |..|  .|
gkltadeAlelvrekRppgapnspsqerlleyfael
0051082 (Phosphotyrosine protein) phosphatases II 32-152 9.7e-26 85.6 In-house 22-145 (151) alignment 
Range on Protein: 32-152
Range on HMM: 22-145/151.0
VEHFIQELKQRQIKEVVRVCEPT---YDAAVLKQEDIEVMDMPFDDGGVPSSEIIDQWLALLKMRFKETPKSCVAVHCVAGLGRAPLMVALALMEAGMTY
 ..|...||. .|| .| .....   |..  |....|||...|..|  .|. ... .... .   . .... .|.||| ||.||  ..||| ||  |...
ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsl

EDAVEFVREKRRGAINAKQLHFLE
|.|.|..|.|| |... .| ....
eealeeyrlkrpgvvqpnqqflfq
subfamily_CDC14_pd Subfamily CDC14 32-155 1e-21 72.1 In-house 201-320 (328) alignment 
Range on Protein: 32-155
Range on HMM: 201-320/328.0
VEHFIQELKQRQIKEVVRVCEPTYDAAVLKQEDIEVMDMPFDDGGVPSSEIIDQWLALLkmrfkETPKSCVAVHCVAGLGRAPLMVALALME-AGMTYED
 |....  .......|||. .  |||   ... .. .|. | ||..||..|. ..|...     |. .  .|||| |||||.  ..|  ||.  ..| ..
PeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleia.....ekaeGaiavhCkaGLGrtGtLiacylmkhyrftaae

AVEFVREKRRGAINAKQLHFLERYK
|. ..|  | | . ..| .|||. .
aiawlricrPGsvigpqqkfleekq
subfamily_DSP23_pd Subfamily DSP23 34-145 2.2e-09 32.1 In-house 25-131 (148) alignment 
Range on Protein: 34-145
Range on HMM: 25-131/148.0
HFIQELKQRQIKEVVRVCEPTYDAAvlkqEDIEVMDMPFDDGGVPSSEIIDQWLALLKMrfKETPKSCVAVHCVAGLGRAPLMVALALM-EAGMTYEDAV
... .|  | .  .   ..|  .|.     .. .. .  ||   |. | ..... ...    |  .  |.|||. | ||.  |.|  |. | ...  .|.
rylldlgvrylvslteegrphveat....pnltlvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerklaaaeai

EFVREKRRGAINA
  ||..| |....
aevrrlrpgsvet
0048179 (Phosphotyrosine protein) phosphatases II 36-157 9.8e-25 82.4 In-house 22-143 (144) alignment 
Range on Protein: 36-157
Range on HMM: 22-143/144.0
IQELKQRQIKEVVRVCEPtYDAAVLKQEDIEVMDMPFDDGGVPSS-EIIDQWLALLKMRFKetPKSCVAVHCVAGLGRAPLMVALALM-EAGMTYEDAVE
...||. .|. |....|. |. . |..| |... .|..| |||.. |.....|....   .  .. .|.||| ||.||....||. || . |...|.|..
lellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

FVREKRRGAI-NAKQLHFLERYKPR
.||..| ||. |  ||.||..| ..
lvrsrrpgavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 36-158 9.4e-24 79.2 In-house 22-142 (145) alignment 
Range on Protein: 36-158
Range on HMM: 22-142/145.0
IQELKQRQIKEVVRVcepTYDAAVLKQEDIEVMDMPFDDGGVPSS-EIIDQWLALLKMRFKETpkSCVAVHCVAGLGRAPLMVALALMEA-GMTYEDAVE
...||. .|. |...   |..   |....|... .|..| |||.. |.....|....   ||    .|.||| ||.||....||. ||   |...|.|.|
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleeale

FVREKRRGAI-NAKQLHFLERYKPRL
.||..|.||. |  ||.||...  .|
lvrsqrpgavpnpgqlrflyefelel
DSPc Dual specificity phosphatase, catalytic domain 36-146 1.8e-12 42.3 Pfam-A 11-120 (133) alignment 
Range on Protein: 36-146
Range on HMM: 11-120/133.0
IQELKQRQIKEVVRVCEPTYDAAVLKQEDIEVMDMPFDDggvPSSEIIDQWLALLK--MRFKETPKSCVAVHCVAGLGRAPLMVALALME-AGMTYEDAV
 . |.. .|. |. | . .  .   |...|| ...| .|    ... | ..|  ..  ..  |. .  |.||| ||. | . ...  ||.  ......|.
lalleklgitlvinvtkevpnnnaikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAy

EFVREKRrGAINAK
|||.|.| ..|. .
efvkerr.skispn
DSPc Dual specificity phosphatase, catalytic domain 36-146 1.8e-12 42.3 In-house 11-120 (133) alignment 
Range on Protein: 36-146
Range on HMM: 11-120/133.0
IQELKQRQIKEVVRVCEPTYDAAVLKQEDIEVMDMPFDDggvPSSEIIDQWLALLK--MRFKETPKSCVAVHCVAGLGRAPLMVALALME-AGMTYEDAV
 . |.. .|. |. | . .  .   |...|| ...| .|    ... | ..|  ..  ..  |. .  |.||| ||. | . ...  ||.  ......|.
lalleklgitlvinvtkevpnnnaikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAy

EFVREKRrGAINAK
|||.|.| ..|. .
efvkerr.skispn
subfamily_DSP6_pd Subfamily DSP6 36-141 6.9e-08 26.2 In-house 32-136 (158) alignment 
Range on Protein: 36-141
Range on HMM: 32-136/158.0
IQELKQRQIKEVVRVCePTYDAAVLKQEDIEVMDMPFDDGGvpSSEIIDQWLALL-KMRFKETPKSCVAVHCVAGLGRAPLMVALALM-EAGMTYEDAVE
.. ||. .|| |. |  .  . .  ...... . .| .|    | ..   .   .  .    . || | ||| ||. |.  ..   || .  .. .|| .
levlkklkikyvlnvt.snlpnkfeesgelkylqipiedhl..sqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndayd

FVREKRRG
.|....  
lvkkrksn
subfamily_DSP19_pd Subfamily DSP19 36-142 1.9e-07 25.5 In-house 30-133 (152) alignment 
Range on Protein: 36-142
Range on HMM: 30-133/152.0
IQELKQRQIKEVVRVCEPTYDAavlKQEDIEVMDMPFDDggVPSSEIIDQWLALLKMRFKETPK-SCVAVHCVAGLGRAPLMVALALM-EAGMTYEDAVE
 ..||...|  .. |   . ..     .|.... ..  |  .|  ...... . |.   .   |  .| ||| ||  |.. .|   || .  ...|.|.|
keilkekkitHilnvatgvpnv...fpkdftylsieilD..lpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleeale

FVREKRRGA
 |||.|. .
lvrearpci
subfamily_Slingshot_pd Subfamily Slingshot 37-156 5.6e-08 26.3 In-house 38-155 (169) alignment 
Range on Protein: 37-156
Range on HMM: 38-155/169.0
QELKQRQIKEVVRVCEP--TYDAAVLKQEDIEVMDMpfddggvPSSEIIDQWLALLKM-RFKETPKSCVAVHCVAGLGR-APLMVALALMEAGMTYEDAV
.|||..... .. | .    . . ...  .| |.|        ........|    |. .   . .| | |||  |. | |  ..| |. | |...|.|.
eelkengveyilnvtkeidnffpekfeylnirvyde.......eetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleeal

EFVREKRRGA-INAKQLHFLERYKP
|.|.|.|. .  |.  |. || |. 
eyvkerrsvikPnkgflkqleeyeG
subfamily_DSP14_pd Subfamily DSP14 37-140 4.5e-06 20.7 In-house 25-125 (157) alignment 
Range on Protein: 37-140
Range on HMM: 25-125/157.0
QELKQRQIKEVVRVCEptyDAAVLKQEDIEVMDMPFDDGgvPSSEIIDQWLAL-LKMRFKETPKSCVAVHCVAGLGR-APLMVALALMEAGMTYEDAVEF
..||...|  .. |     ..   | .|||.. .| .|   |.... . .     |..  .. . .. ||||||  | | |..|  .  . .. ..| . 
ellkkkkitliinvtv...elpntklkdiervkvpveDn..peaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreaykl

VREKRR
|...| 
vksaRp
PTPc_motif_SM00404 38-151 5.9e-13 43.9 In-house 22-131 (140) alignment 
Range on Protein: 38-151
Range on HMM: 22-131/140.0
ELKQRQIKEVVRVCE---PTydaavLKQEDIEVMDMPFDD-GGVPSSEIIDQWLALLKMRfkETPKSCVAVHCVAGLGRAPLMVALALME-AGMTYEDAV
 ||. .|. |. | |    |      ........ .| || .  . |. .|. |. ..    |. .  | ||| ||. |   ...  ||.  ......|.
llkklgithvinvteevslt.....kensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeay

EFVREKRrgAINAKQLHFL
|||.|.|   |  ..|.|.
efvkerR..piispnlnfv
subfamily_DSP1_pd Subfamily DSP1 38-140 1.9e-07 25.3 In-house 38-137 (163) alignment 
Range on Protein: 38-140
Range on HMM: 38-137/163.0
ELKQRQIKEVVR---VCEPTYDAaVLKQEDIEVMDMPFDDGGVPSSEIIDqwlaLLKMRFKEtpKSCVAVHCVAGLGRAPLMVALALME-AGMTYEDAVE
 ||. .|  ..     .. ...  ... . ... | | .|  .  .|.|.     ..   |.  .  | .|| ||. |.  .. . ||.   ...|.| .
iLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfeevie....fidevkkk..nGkvlihCqaGisRsstlclaylmktkrvsleeafd

FVREKRR
||...| 
fvkqrRs
subfamily_DSP12_pd Subfamily DSP12 38-151 6.9e-07 23.8 In-house 22-139 (155) alignment 
Range on Protein: 38-151
Range on HMM: 22-139/155.0
ELKQRQIKEVVRVCEPTYDAAVLKQE-----DIEVMDMPFDDggvpSSEIIDQWLALLKMRFKEtpKSCVAVHCVAGLGRAP-LMVALALMEAGMTYEDA
 ||. .|..|. | . . .   ||.       |...|.|  |      . .|. .. ..   .|  .  | ||| ||. |   ...|  . . ..  |.|
llkelkithvlsvikeelpehklkkgkvstkfiqilDepeed....iLshldeavdFieealee..egavlvHCqagvSRSvtiviAYlmkkeklslekA

VEFVREKRRGAI-NA---KQLHFL
...|.||.. .  |.   .||.  
lklvkekkpeiepNegFleQLklf
subfamily_DSP8_pd Subfamily DSP8 39-153 3.4e-08 27.2 In-house 36-146 (159) alignment 
Range on Protein: 39-153
Range on HMM: 36-146/159.0
LKQRQIKEVVRVCEPTYDAAVLKQEDieVMDMPFDDGGvpSSEIIDQWLALLKMRFK-ETPKSCVAVHCVAGLGRAPL-MVALALMEAGMTYEDAVEFVR
|..  |  |. . .   .  .||..   .. .|  |    . .... . . ...  |  . ...| ||. ||  |..  ..|  . .  |....| .||.
lsklgisyvlnasnscpkleelkesk..flrvPvkDky..dekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvk

EKRrGAINaKQLHFLER
|||  .|. ..| ||..
ekr.ptis.pnlnflgq
subfamily_DSP15_pd Subfamily DSP15 39-143 8e-08 26.5 In-house 23-123 (151) alignment 
Range on Protein: 39-143
Range on HMM: 23-123/151.0
LKQRQIKEVVRVCEptydAAVLKQEDIEVMDMPFDD-GGVPSSEIIDQWLALL-KMRFKEtpkSCVAVHCVAGLGRAPLMVALALMEA-GMTYEDAVEFV
||...|  .. | .     |    .|||   .. .|  ..  |.....   .. | | ||     | |||.||. |.  .|.. || .  . ..||.|..
Lkeknithilsvhd....nakkllkdieYkciaasDtpsaklskffkesvefihkcRlke...envlvhClaGvsRsvtlvvaYlmtvtelnwrdalevi

REKRRGAI
...|  | 
kaaRsvan
subfamily_PTPMT1_pd Subfamily PTPMT1 41-158 4e-11 37.7 In-house 44-168 (171) alignment 
Range on Protein: 41-158
Range on HMM: 44-168/171.0
QRQIKEVVRVCEPtYD-------AAVLKQEDIEVMDMPFDDGG-VPSSEIIDQWLALLKMRfkETPKSCVAVHCVAGLGRAPLMVALALM-EAGMTYEDA
. ..| || ..|  |.           |....| . ..  |    |. | . . . ...     . ...| ||| || ||.  .||  || .  .. |.|
kenvkavvslnee.yelkalansteewkklgveqlqlatvDfteapdleklekgvefiekv..askgkrvYvHCkaGrgRsatlvacylmkkeklspeeA

VEFVREKRRG-AINAKQLHFLERYKPRL
......||.   .. ||.. |..|.  |
lkalkkkRkiirlakkqwkalqeyeekl
0048567 (Phosphotyrosine protein) phosphatases II 47-153 1.7e-11 38.7 In-house 25-132 (157) alignment 
Range on Protein: 47-153
Range on HMM: 25-132/157.0
VvrvcePTYDAAVL-KQEDIEVMDMPFDDGgVPSSEIIDQWLALLKMRFK--ETPKSCVAVHCVAGL---GRAPLMVAL-ALMEAGMTYEDAVEFVREKR
       .|.| ..  ....  .|. ||.|  ..  |. ..  .|.  .|  |  .  .|||| |||   ||. ..... ...  |.| |.|....|  |
k.....slynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr

RGAINAKQLHFLER
 | .   . ..|..
pgsvpfrdasylls
subfamily_RNGTT_pd Subfamily RNGTT 52-156 5.4e-11 36.5 In-house 65-173 (189) alignment 
Range on Protein: 52-156
Range on HMM: 65-173/189.0
EPTYDAAVLKQEDIEVMDMPFDDGGV-PSSEIIDQWLALLKMRFKETPKSCVAVHCVAGLGRAPLMVALALME-AGMTYEDAVEFVREKRRGAINAKQL-
.. ||.  |..|.|. . .     |. |..| ....  |..  ||..|.. ..|||  |  |.  ...  |.|   .  |.||.  .. |   |  ..  
sryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedyl

-HFLERYKP
  .|.||. 
kellrrYad
subfamily_DSP11_pd Subfamily DSP11 53-143 3e-07 24.5 In-house 68-161 (178) alignment 
Range on Protein: 53-143
Range on HMM: 68-161/178.0
PTYDAAVLKQEDIEVMDMPFDDGGVPSSEIIDQWLALLKMRF--KETPKSCVAVHCVAGLGRAPLMVALALME-AGMTYEDAVEFVREKRRGAI
  |.   |..|... . .      ||..|..... . .|     ..  .. ..|||  |. |.  ..   |..  |.  |||.|   | |  ..
ryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsl
subfamily_PTPDC1_pd Subfamily PTPDC1 54-155 4.6e-15 50.5 In-house 72-172 (182) alignment 
Range on Protein: 54-155
Range on HMM: 72-172/182.0
TYDAAVLKQEDIEVMDMPFDDGGVPSSEIIdqwLALLKMRFKETPKSCVAVHCVAGLGRAPLMVALALM-EAGMTYEDAVEFVREKRRGAINAK-QLHFL
.||   |....| |. ....| ||.| | |   | . |.      .  ||||| |||||. ...|  |.    .| |.|...||.||  .|... |....
sYdlealmeqgiyvynfgwkDygvasleri...LdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv

ERYK
. ..
kefa
subfamily_CDKN3_pd Subfamily CDKN3 61-157 5e-10 33.3 In-house 96-194 (202) alignment 
Range on Protein: 61-157
Range on HMM: 96-194/202.0
KQEDIEVMDMPFDDGGVPSSEIIDQWLALLKMRFKETPKScvAVHCVAGLGRAPLMVALA--LMEAGMTYEDAVEFVREKR-RGAIN-AKQLHFLERYKP
.|  . |   |. ||.||.     . |  |.. .|.  |.   |||  ||||. |..|    ...  . ..||.. .|. .  .||.  ||  .|. .. 
qqaglivhhypiadglvpdiasclkileelrinlkayrkt..lvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefrd

R
.
k
subfamily_PTPN13_pd Subfamily PTPN13 64-148 2.4e-07 25.3 In-house 165-257 (273) alignment 
Range on Protein: 64-148
Range on HMM: 165-257/273.0
DIEVMDMPF---DDGGVPSSEIiDQWLALLKMRFKETPKSCVAVHCVAGLGRAPLMVA----LALMEA--GMTYEDAVEFVREKRRGAINAKQL
 .||... |    | |||||   .    . ..|  .| .. ..||| ||.||.  ...    | |.|    .  .. |. .||.|.| . .|. 
srevahlnfvkwPdhgvPssaa.ellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdq
PTPc_DSPc_SM00012 74-146 1.5e-08 30.1 In-house 12-93 (105) alignment 
Range on Protein: 74-146
Range on HMM: 12-93/105.0
DGGVPSS-EIIDQWLALLKMRFKE-TPKSCVAVHCVAGLGRAPLMVALALMEAGMTYE-------DAVEFVREKRRGAINAK
| |||.. . | ..|. .|   .. . .. | ||| || ||.  .|||...   ...|       . |. .|..|.|... .
dhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte
Y_phosphatase Protein-tyrosine phosphatase 74-151 9.5e-08 27.1 Pfam-A 145-229 (235) alignment 
Range on Protein: 74-151
Range on HMM: 145-229/235.0
DGGVPSSeiIDQWLALLKMRFKET--PKSCVAVHCVAGLGRAPLMVALALMEAGMTY------EDAVEFVREKRRGAINA-KQLHFL
| |||.|   .. | |...  |..   .. | ||| || ||.  .||| ..   ..        ..|. .|..|.|...  .|. ||
dhgvpes..pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 74-151 9.5e-08 27.1 In-house 145-229 (235) alignment 
Range on Protein: 74-151
Range on HMM: 145-229/235.0
DGGVPSSeiIDQWLALLKMRFKET--PKSCVAVHCVAGLGRAPLMVALALMEAGMTY------EDAVEFVREKRRGAINA-KQLHFL
| |||.|   .. | |...  |..   .. | ||| || ||.  .||| ..   ..        ..|. .|..|.|...  .|. ||
dhgvpes..pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
subfamily_DSP3_pd Subfamily DSP3 96-159 4.8e-08 26.8 In-house 94-158 (162) alignment 
Range on Protein: 96-159
Range on HMM: 94-158/162.0
ETPKSCVAVHCVAGLGRAP-LMVALALMEAGMTYEDAVEFVREKRRGAINAKQLHFLERYKPRLR
..... | ||||.|. |.. |..|  ..   ||  .|.. ||.||.   |   |. |  .. .|.
sqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelk
subfamily_DSP10_pd Subfamily DSP10 98-150 2.8e-07 24.6 In-house 91-142 (159) alignment 
Range on Protein: 98-150
Range on HMM: 91-142/159.0
PKSCVAVHCVAGLGRA-PLMVALALMEAGMTYEDAVEFVREKRrgAINAKQLHF
  | | ||| ||. |.  ...|  . . ... .|| .||.|||  .| .  | |
kgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekr..piisPnLnf
subfamily_STYX_pd Subfamily STYX 101-155 4.9e-06 19.7 In-house 98-154 (166) alignment 
Range on Protein: 101-155
Range on HMM: 98-154/166.0
CVAVHCVAGLGRAPLMVALALME-AGMTYEDAVEFVREKRRG-AINAKQLHFLERYK
 | ||  ||. |.  .|   .||  |. | .|  .|.|.|   . |.   . |. |.
kvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye