Gene SSH in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily Slingshot
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP026_AA protein Get Run
SpurP026_AA_495-640 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
zf-DHHC DHHC palmitoyltransferase 62-213 1.3e-41 128.2 Pfam-A 2-156 (174) alignment 
Range on Protein: 62-213
Range on HMM: 2-156/174.0
INFLLATFVDPGVFPRT--AVGDEDRDDDLRAPLYKTVQIRGIQVRMKWCSTCRFYRPPRCSHCSVCNNCIERFDHHCPWVNNCVGRRNYRYFFLFLLSL
. ..|..|.|||..||.  .   | ..|.      .  .  . . . ..|..|....|||. ||..||.|. .|||||||||||.|.||..||.||||.|
ssyiltyftdPgyvprssqdesneeeedkeekqraiqteaelknnekrfCkkCqiikpprshHCriCnkCvlkfDhHCpwvnncIGarNhkyFllfllyl

TMHMVSVFVLSLIYVLQAKASISDYQKIISSVTN-TYTWPVYGPLLAFGICLCLV
|. .| ...|||.....   . .  .  | |. .  ..  .   .|.| ..|...
tlllvialllslrifvryvlltkqssvniisnlskillvvisaiallfllallaf
DEK_C DEK C terminal domain 447-489 1.1e-12 37.2 Pfam-A 8-50 (54) alignment 
Range on Protein: 447-489
Range on HMM: 8-50/54.0
KLKEIMIQCDLETVTSKMVRISLEKEIGKELKEYKRFIDKQIL
...||. . ||||||.| ||  ||...| .|.|.| ||...| 
evreiLkeaDLetvTkkqvrkeLearlgvdLserKafIkdlie
subfamily_Slingshot_pd Subfamily Slingshot 480-646 7.3e-89 289.6 In-house 1-167 (169) alignment 
Range on Protein: 480-646
Range on HMM: 1-167/169.0
YKRFIDKQILLICGQLDSASKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKAL
|| |||...|.| ||||||||||||.|||||||||.|.||.|||| ||||.|||.||||||.|.|.|||.||. |.|||..||.|| |..|||..|||.|
ykefidnemlvilgqldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvl

VHCKMGISRSASTVIAYAMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGILEASRQRHTMF
||||||.||||||||||||||||..|| ||..|| .||.|.||..|.|||..||||||||.|||...
vhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqrhnkl
0044763 (Phosphotyrosine protein) phosphatases II 492-637 3.8e-37 123.0 In-house 17-171 (178) alignment 
Range on Protein: 492-637
Range on HMM: 17-171/178.0
CGQLDSASKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPER---------FKYCNIRLYDDVEEDLLNHWNTTYLFLSKAK-EAGSKALVH
...   ||.|....|||| ..|.||. | |.|...|.|.|.|. ..|..          ..|..| . |. . ||| |.  .. |. .|  | |.. |||
rsdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CKMGISRSASTVIAYAMKEYGMTLEYALDFVKGKRSiIRPNDAFMKQLQVYEGILE
|..|..||.. |.|| ||..|..|| |...|. .|. | ||. ...||. .| .| 
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 492-636 7.4e-32 104.5 In-house 114-258 (263) alignment 
Range on Protein: 492-636
Range on HMM: 114-258/263.0
CGQLDSASKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPERFKYCNIRLYDDV-EEDLLNHWNTTYLFLSKAKEAGSkALVHCKMGISRSA
  .    ..| |...||.   | .   |...|| .||    ... .||. |||  |   .|| | |. .|.. |  |. . .. |   ||||. |.|||.
tlvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrss

STVIAYAMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGIL
. ||.| ||   .... |||.|. ||. |.||  |..||. ||  |
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
subfamily_DSP14_pd Subfamily DSP14 496-640 1e-34 113.8 In-house 5-148 (157) alignment 
Range on Protein: 496-640
Range on HMM: 5-148/157.0
DSASKIFDHIYLGsEWNASDLDELEENGVGYILNITKECDNFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIA
 . |.| ....|.    |.. ..|.....  |.|.| |  |   . ... .... |. |..| .|.....  . ..|..| |.||||..|.||||| ..|
aalsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

YAMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGILEASR
| ||   ..|. |   || .|.|||||  | |||. ||  |... 
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
subfamily_DSP1_pd Subfamily DSP1 497-637 1.7e-44 145.8 In-house 17-157 (163) alignment 
Range on Protein: 497-637
Range on HMM: 17-157/163.0
SASKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAY
   || |..||||| .||.|. |...|.  |||..||.||.|.. |.| .. | |  ..|.  ....   |. ..|... | |.||..|||||.. ..||
PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclay

AMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGILE
 ||.  ..|| | |||| .||||.|| .|..||  ||  |.
lmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP3_pd Subfamily DSP3 497-636 2.6e-28 92.7 In-house 10-157 (162) alignment 
Range on Protein: 497-636
Range on HMM: 10-157/162.0
SASKIFDHIYLGSEWNASDLDELEENGVGYILNITKE-------CDNFFP-ERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEA-GSKALVHCKMGIS
..  .....|.| |  |.| ..|.. |. ..|| ..         ..|.    .||. . . |  | || ....|.  |. .| .   .| ||||..|.|
evdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvs

RSASTVIAYAMKEYGMTLEYALDFVKGKRSIiRPNDAFMKQLQVYEGIL
|||  |.|| |    |||  |.  |. ||.| .||. |.|||. ..  |
RsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeel
0046846 (Phosphotyrosine protein) phosphatases II 497-634 6.6e-26 86.5 In-house 11-170 (176) alignment 
Range on Protein: 497-634
Range on HMM: 11-170/176.0
SASKIFDHIYLGSEW----------NASDLDELEENGVGYILNITKE-------CDNFFPE----RFKYCNIRLYDDVEEDLlNHWNTTYLFLSKAKEAG
. . | ....||| .           |..|..| |.|.....|.|.|       |.|..||     ..|...   |    || ... . . |. .| ..|
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg

SKALVHCKMGISRSASTVIAYAMKE-YGMTLEYALDFVKGKRS-IIRPNDAFMKQLQVYEG
 . ||||..||.|..  |.|| ..  .|...| ||..|. .|.  . ........|. .| 
gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
subfamily_DSP10_pd Subfamily DSP10 498-639 1.5e-41 135.9 In-house 14-156 (159) alignment 
Range on Protein: 498-639
Range on HMM: 14-156/159.0
ASKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPE-RFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAY
||... ...|||| .|.||| |.. .. ..||.|... |.| |  .||  | . |  ...| ....  . |. .|.. ||. ||||. ||||||. ||||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

AMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGILEAS
 ||. ...|. | .||| ||.|| || .|| ||  .|  |. |
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
subfamily_DSP19_pd Subfamily DSP19 498-635 3e-38 125.5 In-house 12-149 (152) alignment 
Range on Protein: 498-635
Range on HMM: 12-149/152.0
ASKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYA
.... ...||||   |.| ..|.|... .|||.. . .|.||. |.|..| ..|. |.|||......  |. .|...    ||||. |.||||| |||| 
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGI
||.  ..||.||. |. .|  |.||. |.|||. ||  
mkkeelsleealelvrearpcikPneGFikqLkeyeae
PTPc_motif_SM00404 498-633 1.7e-37 123.4 In-house 2-138 (140) alignment 
Range on Protein: 498-633
Range on HMM: 2-138/140.0
ASKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDN-FFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAY
 |.| .|.||||. .|.... |...|. ...|.|.|...    ..|....| | |. ...|..... .. |...|.. | | ||||..|.||||. .|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

AMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYE
 |......|. |..||| .|.||.||  |..||. ||
lmryrqlslaeayefvkerRpiispnlnfvrqLieye
0048076 (Phosphotyrosine protein) phosphatases II 498-635 1.4e-33 111.0 In-house 4-141 (145) alignment 
Range on Protein: 498-635
Range on HMM: 4-141/145.0
ASKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYA
.|.|....|||| ..|.||..|...|....||.| |....... ..|... . |  . |||... . . |. .| ..| . ||||..|..|... |.|| 
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGI
|...|..|| ||..|. .|... ||. ....|. .| .
mlllgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_DSP8_pd Subfamily DSP8 498-637 1.6e-31 103.0 In-house 15-155 (159) alignment 
Range on Protein: 498-637
Range on HMM: 15-155/159.0
ASKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDN-FFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAY
  .| ...||||. .. . . |...|..|.||. ..| .  . .  |.  . . |. .|.||. ..... |. |||.. .. |||.  ||||||. .|||
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiay

AMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGILE
 ||.  |.|. |  ||| ||  | ||  |..||  ||  |.
imktlemsldeayrfvkekrptispnlnflgqLleyekelk
0041856 (Phosphotyrosine protein) phosphatases II 498-636 6.2e-31 102.8 In-house 19-172 (182) alignment 
Range on Protein: 498-636
Range on HMM: 19-172/182.0
ASKIFDHIYLGSEWN--------------ASDLDELEENGVGYILNITkeCDNFFPERF-----KYCNIRLYDDVEEDllnhWNTTYLFLSKAKEAGSKA
 ..| ...|||| ..              |..|. | |.|...|.|.|  ... .||..     .|...   |.   |    ..... |. ...| | . 
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpv

LVHCKMGISRSASTVIAYAMKEYGMTLEYALDFVKGKRS--IIRPNDAFMKQLQVYEGIL
||||..|..|... |.|| ||..|..|| |...|. .|.  .|.||  |. ||...| .|
lVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
0045098 (Phosphotyrosine protein) phosphatases II 498-633 1.7e-23 78.9 In-house 22-268 (278) alignment 
Range on Protein: 498-633
Range on HMM: 22-268/278.0
ASKIFDHIYLGSEW-----------------------------------------NASDLDELEENGVGYILNIT-------------------------
 |.|....|||. .                                          |.... | |.|. .|...|                         
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

---------------------------KECDNFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKE--------------AGSKALVHCKMGISRSA
                           ... ... . ..| ..  ..  ....|...   . |. .| .               | . ||||..|..|..
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

STVIAYAMKEY---GMTLEYALDFVKGKRSI-IRPNDAFMKQLQVYE
  |.|| |.|.   |..|. |..... .| . . .|  ....|  ..
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefl
0051082 (Phosphotyrosine protein) phosphatases II 498-632 9.2e-23 75.9 In-house 8-149 (151) alignment 
Range on Protein: 498-632
Range on HMM: 8-149/151.0
ASKIFDHIYLGSEWNASDLDELEENGVGYILNITK-----ECDNFFPE-RFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEA-GSKALVHCKMGISRSA
.| . ...|...   | .|..|.|.|. .|.|...      | ...||  .....| . |. . .|  ....   ||... .  . . ||||..|..|..
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

STVIAYAMKeYGMTLEYALDFVKGKRS-IIRPNDAFMKQLQVY
  |..| |. .|..|| ||.... ||  ...||. |..||...
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP6_pd Subfamily DSP6 499-638 9.2e-37 120.0 In-house 15-156 (158) alignment 
Range on Protein: 499-638
Range on HMM: 15-156/158.0
SKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPE--RFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAY
 .| ...||||. .||.|. |.. .. |.||.|.. .|.| |   .|| .| . | ....| ...  .  |. .|... || ||||  |||||   ..||
veilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlay

AMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGILEA
 ||.. ..|. | |.|| ..| | ||  ||.||  .|  |. 
lmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
0048179 (Phosphotyrosine protein) phosphatases II 499-636 1.2e-33 111.2 In-house 5-144 (144) alignment 
Range on Protein: 499-636
Range on HMM: 5-144/144.0
SKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPERF--KYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAY
|.|....|||| . |.||..| ..|.....|.| |... |.||.  .|... . |    |||....... |. .| | | . ||||..|..|... |.||
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

AMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGIL
 ||..|..|| ||..|. .|... ||. ....|. || .|
lmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_DSP12_pd Subfamily DSP12 499-636 4.6e-33 108.8 In-house 3-143 (155) alignment 
Range on Protein: 499-636
Range on HMM: 3-143/155.0
SKIFDHIYLGSEWNASDLDELEENGVGYILNITKEC-DNFFPER--FKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIA
|.| . .|||.  .. . . |.| ..  .| ..||  ... ...   .. .| ..|. |||.|.| ...  |...| | . . ||||..|.|||...|||
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YAMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGIL
| ||.... || ||..|| |.. |.||. |..||...| . 
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 499-633 1e-31 103.5 In-house 8-144 (148) alignment 
Range on Protein: 499-633
Range on HMM: 8-144/148.0
SKIFD-HIYLGSEWNASDLDELEENGVGYILNITKECDNFFPERF-KYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAY
|.| | ...|||   |.||. |.. ||  | | |||.|| . .|  .| ...| |. .|||   ...   |..|||..| . |||..||.|||.  ....
seikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallw

AMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYE
 ..   ..|. ||..|| ||  ..||  |.|||. .|
lidfkrvslkealalvkskrryvdpnlgfLkqLaele
0043147 (Phosphotyrosine protein) phosphatases II 499-636 1.3e-28 95.3 In-house 20-160 (172) alignment 
Range on Protein: 499-636
Range on HMM: 20-160/172.0
SKIFDHIYLGSEWNASDLDELEENGVGYILNITKE---CDNFFPERFKYCNIRLYDDVEEdLLNHWNTTYLFLSK--AKEAGSKALVHCKMGISRSASTV
 ..... .....  |.... | |.|...|.|.|..   ....... ..|. .  .|     ||...  .. |. .  |.. | . ||||..|..|..  |
drfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlv

IAYAMKeYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGIL
.|| |. .|..|| |...|. ||... .|. ....|. .| .|
aaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_DSP15_pd Subfamily DSP15 499-635 4.6e-26 85.7 In-house 3-138 (151) alignment 
Range on Protein: 499-635
Range on HMM: 3-138/151.0
SKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPErFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYAM
||.   .|||   ...| . |.|. .  ||..  .  ..... ..|  |.. |  . .| .. . .  |. |..  . . |||| .|.|||.  |.|| |
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

KEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGI
    .  . ||...| .||.  ||  | .||..||  
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 499-633 1.6e-23 76.7 In-house 4-149 (154) alignment 
Range on Protein: 499-633
Range on HMM: 4-149/154.0
SKIFDHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPER---------FKYCNIRLYDDVEEDLLNHWNTTYLFLSKAK--EAGSKALVHCKMGIS
||   ..|..|   | .  .|... .  |||.    .| |...         ..|.|..|.|||. |.... . .. |. .|      .| |||.. |.|
skeaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvs

RSASTVIAYAMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYE
|||. .|.| |..  ..|  || ..|  | ||.||  |.|||...|
rsaallisylmdklkislslalellkdsryiikPnqGflkqleife
0037934 (Phosphotyrosine protein) phosphatases II 499-633 3e-23 78.1 In-house 40-238 (243) alignment 
Range on Protein: 499-633
Range on HMM: 40-238/243.0
SKIFDHIYLGSE--------WNASDLDELEENGVGYILNITKEC---------------------------------------------DNFFPERFKYC
...........         . ||... | |.|...|...|...                                             |... . ..|.
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

NIRLYD----DVEEDLLNHWNTTYLFLSK-----AKEAGSKALVHCKMGISRSASTVIAYAMKEY-GMTLEYALDFVKGKRSI-IRPNDAFMKQLQVYE
 .   |    |  ||||.... .. |...     |   |.. ||||..|..|..  ..|| |... |..|| |..... .|.  . ..  ....|. ..
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
0036282 (Phosphotyrosine protein) phosphatases II 499-636 9.3e-22 73.0 In-house 13-169 (174) alignment 
Range on Protein: 499-636
Range on HMM: 13-169/174.0
SKIFDHIYLGSEWNAsDLDELEENGVGYILNITKEC---------------DNFFPERFKYCNIRLYDDVEEDLLNhWNTTYLFLSKAKEA--GSKALVH
| | .....|.   | ....| |.|. .... ..|.               . . .. ..|. .   |. . ||   . . . |. .| .   | . |||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CKMGISRSASTVIAYAMKEYGM-TLEYALDFVKGKR---SIIRPNDAFMKQLQVYEGIL
|..|..|..  |.|| |. ... .|. |||.|. .|   . . ... ....|. .| .|
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0042113 (Phosphotyrosine protein) phosphatases II 499-633 2.8e-19 65.0 In-house 48-239 (245) alignment 
Range on Protein: 499-633
Range on HMM: 48-239/245.0
SKIFDHIYLGSEWNASDLD----ELEENGVGYILNITKEC----------------------------------------------DNFFPERFKYCNIR
..| .......   .....     | |.|. .|...|.|                                               |..  | . |. . 
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

LYDDVEEDLLNHWNTTYLFLSKAKE--AGSKALVHCKMGISRSASTVIAYAM-----KEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYE
  |. . |||..    . |. || .  .. . ||||..|..|..  ..|| |     ||.|..|| |..... .|. ..... ....|. ..
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0049260 (Phosphotyrosine protein) phosphatases II 500-636 2.1e-26 87.8 In-house 10-149 (152) alignment 
Range on Protein: 500-636
Range on HMM: 10-149/152.0
KIFDHIYLGSEWNASDLDELEENGVGYILNITKECDN---FFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSK-AKEAGSKALVHCKMGISRSASTVIA
..  ....|... |.... | |.|...|...|.....   .... ..|...   |.   ||  .    .||. | |.. | . ||||. |..|..  |.|
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

YAMKeYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGIL
| |. .|..|| |...|. ||... ||  ....|. .|..|
ylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_STYX_pd Subfamily STYX 500-641 1.1e-25 83.6 In-house 14-162 (166) alignment 
Range on Protein: 500-641
Range on HMM: 14-162/166.0
KIFDHIYLGSEW--NASDLDELEENGVGYILNITKECD-----NFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSAST
.|.  ..||       | |. |...|. .|. | .. .       ||.||.|  . . |.. |... .  |.  |. .. . | | ||| . ||||||. 
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

VIAYAMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGILEASRQ
|||| |. ||.    |  .|. .|  | ||. |..||..|| |  |  .
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylaklt
PTEN_1 500-639 4.7e-24 80.3 In-house 43-194 (196) alignment 
Range on Protein: 500-639
Range on HMM: 43-194/196.0
KIFDHIYLGSEWNA-SDLDELEENGVGYILNITKECDN---------FFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKE--AGSKALVHCKMGIS
.|... |.||.  . .|||.|.|.|.  ..| . |...         || ....| ..   |.   .|  ..   . | . ...   | ..||||| |..
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RSASTVIAYAMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGILEAS
||.  |.|| |. ...| . ||..|. ||. ..|| .....|. |.  | |.
RsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0049772 (Phosphotyrosine protein) phosphatases II 501-650 9.1e-32 106.4 In-house 150-287 (314) alignment 
Range on Protein: 501-650
Range on HMM: 150-287/314.0
IFDHIYlgSEWNASDLDELEengvgyilnitKEC--DNFFPER-FKYCNIRLYDdVEEDLLNHWNTTYLFLSKAkEAGSKALVHCKMGISRSAS-TVIAY
|.|  .  .|..|.||..|.           .|.  ...|... .||..| ..|  ...||....  . |. .| ..|.. |||||.|..|...  |.||
ildgng..neptaadlellk...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaay

AMKEYGMTLEYALDFVKGKRSiIRPNDAFMKQLQVYEGILEASRQRHTMFRSKS
 || .|..|| ||..|. ||. |.||. |..||. || ||||....  ......
lmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkflkkfy
0040439 (Phosphotyrosine protein) phosphatases II 501-632 8.3e-23 76.7 In-house 32-241 (249) alignment 
Range on Protein: 501-632
Range on HMM: 32-241/249.0
IFDHIYLGSEWNASDLDE------------------------LEENGVGYILNITKECDN----------------------------------------
|..  .|..  ||| .|                         | |.|...|...|... .                                        
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---FFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKE------AGSKALVHCKMGISRSASTVIAYAM-----KEYGMTLEYALDFVKGKRSIIRPN
    ..| ...  |. .|  . ..  . ...  |. ....       |.. ||||..|..|..  ..|| |     ||.|..|| |..... .|. . .|
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

DAFMKQLQVY
. ....|. .
peqyrflyea
0036941 (Phosphotyrosine protein) phosphatases II 502-633 1.1e-15 53.2 In-house 23-273 (297) alignment 
Range on Protein: 502-633
Range on HMM: 23-273/297.0
FDHIYLGSE----------------------------------WNASDLDELE------------------------ENGVGYILNITKE-------CDN
.....|||                                    ||| .|  .                        |..|  |...|..       |. 
lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaq

FFPER---------------------FKYCNIRL---Y----------------DDVEEDLLNHWNTTYLFLSKAKE------AGSKALVHCKMGISRSA
..|.                      .... .|    .                .  . .. .....   |. ....       |.. ||||..|..||.
ywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsg

STVIAYAM--------KEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYE
. ..|. |        ||.|...  |. ... .|  . ..  ....|  ..
tfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal
subfamily_MKPLT_pd Subfamily MKPLT 503-635 2.4e-30 99.2 In-house 27-159 (164) alignment 
Range on Protein: 503-635
Range on HMM: 27-159/164.0
DHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYAMKEYG
|..|||   .| .   |..  . .|.|...|. . ||. ..| .... | ..| | .. . .  ||..| ..| . |||| .| |||.|. .|. .|  |
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

MTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGI
 ||. | ...| .|||..||  |.|||  .| .
wtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 503-635 2.4e-30 99.2 In-house 27-159 (164) alignment 
Range on Protein: 503-635
Range on HMM: 27-159/164.0
DHIYLGSEWNASDLDELEENGVGYILNITKECDNFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYAMKEYG
|..|||   .| .   |..  . .|.|...|. . ||. ..| .... | ..| | .. . .  ||..| ..| . |||| .| |||.|. .|. .|  |
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

MTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGI
 ||. | ...| .|||..||  |.|||  .| .
wtlkeayeylkerrsivapnrGflkqlakfeel
subfamily_STYXL1_pd Subfamily STYXL1 504-634 1.7e-17 57.1 In-house 18-151 (157) alignment 
Range on Protein: 504-634
Range on HMM: 18-151/157.0
HIYLGSEWNASDLDELEENGVGYILNITKECDNFFPER---FKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYAMKE
..||| . .| .    ..  |   .|.....|...       |  .|.. |. | |||.. .    |. | |. |.  ||  . ||||||. .||| | .
klylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmys

YGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEG
. .||. |....|  .. ..|| ||..||. .| 
kkitlkkaykylkkCkenvkPnrafveqlseWek
0051429 (Phosphotyrosine protein) phosphatases II 504-632 4.8e-16 54.7 In-house 22-220 (272) alignment 
Range on Protein: 504-632
Range on HMM: 22-220/272.0
H-IYLGSEW---NASDLDELEENGVGYILNITKECD------NFFPERFKYCNIRLYDDVEEDLLNHW--------------------------------
. .|... .   .| |.. |.|.|. .|.....|.        .... ..|... ..||.... | ..                                
grlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------NTTYLFLSKAKEaGSKALVHCKMGISRSASTVIAYAMKeYGMT--------------LEYALDFVKGKRSIIRPNDAFMKQLQV
                ..   .|.   . | . ||||. |..|..  | .. .  .|..              || |.. .. .|  ..........|. 
vmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

Y
.
a
DSPc Dual specificity phosphatase, catalytic domain 505-633 5.4e-33 108.7 Pfam-A 1-131 (133) alignment 
Range on Protein: 505-633
Range on HMM: 1-131/133.0
IYLGSEWNASdLDELEENGVGYILNITKECDN---FFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYAMKEY
.||||. .|| |. ||..|. ...|.|||..|   . .....| .| . |. |... .. . .. |..||.. | | ||||..||||||. .||| ||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GMTLEYALDFVKGKRSIIRPNDAFMKQLQVYE
...|. |..||| .||.|.||. |..||  ||
nlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 505-633 5.4e-33 108.7 In-house 1-131 (133) alignment 
Range on Protein: 505-633
Range on HMM: 1-131/133.0
IYLGSEWNASdLDELEENGVGYILNITKECDN---FFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYAMKEY
.||||. .|| |. ||..|. ...|.|||..|   . .....| .| . |. |... .. . .. |..||.. | | ||||..||||||. .||| ||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GMTLEYALDFVKGKRSIIRPNDAFMKQLQVYE
...|. |..||| .||.|.||. |..||  ||
nlslneAyefvkerrskispnagflrqLleye
0038934 (Phosphotyrosine protein) phosphatases II 505-636 4.1e-17 57.9 In-house 38-176 (194) alignment 
Range on Protein: 505-636
Range on HMM: 38-176/194.0
IYLGSEWNASDLDELEENGVGYILNITKECDNFFPERFKYCNIRLYDDVEED--------LLNHWNTT-YLFLskAKEAGSKALVHCKMGISRSASTVIA
.|  | ..  .. .|   ..|.....|..   . ||.|.  .|. ..   .|        .|...    . ||  .. .| . .||||.|..|..  |.|
lyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaa

YAMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEGIL
| .. .||..| |..... ||  . ||  ....|... . |
YLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 505-630 9.4e-16 51.2 In-house 6-135 (145) alignment 
Range on Protein: 505-630
Range on HMM: 6-135/145.0
IYLGSEWNASDLDELEENGVGYILNITKE----CDNFFPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYAMKE
.| ||  .|.|.  |.| |.  |.|..      ...   | ..   |   |    || .|..    |. | || |.  .|||  |.||| .  .|. || 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

YGMTLEYALDFVKGKRSIIRPNDAFMKQLQ
 .|||  |   |. .|    ||  |.|.| 
cnmtlseaarqvrsnrllaypnvtflknll
0045450 (Phosphotyrosine protein) phosphatases II 512-633 1.5e-20 69.6 In-house 88-300 (307) alignment 
Range on Protein: 512-633
Range on HMM: 88-300/307.0
NASDL--------------------------------DELEENGVGYILNITKE-------CDNFFPER---------------------FKYCNIRLYD
|||                                    | |.||..|...|..       |. ..|.                      ... .... |
NAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtd

D-----------------VEEDLLNHWNTTYLFLSKAKE------AGSKALVHCKMGISRSASTVIAYAMKEYG--------MTLEYALDFVKGKRSIIR
                   . ..  .....  |. ....       |.. ||||..|..|... ..|| |....        ..|. |..... .|. . 
ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav

PNDAFMKQLQVYE
.|  ....|. ..
qnpeqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 518-632 3.1e-19 64.9 In-house 105-271 (317) alignment 
Range on Protein: 518-632
Range on HMM: 105-271/317.0
ELEENGVGYILNITKECDN---------------------------FFPERFKYCNIRLYDD----------------VEEDLLNHWNTTYLFLSKAKEA
 . |.||..|...|.....                           .  . ... .....|.                 . ..  ....   ||....||
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GSKALVHCKMGISRSASTVIAYAM-----KEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVY
    |.. ||||..|..|... ..|| |     ||.|...| |..... .|. . .. .....|  .
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0039614 (Phosphotyrosine protein) phosphatases II 518-633 6.9e-16 54.0 In-house 120-285 (297) alignment 
Range on Protein: 518-633
Range on HMM: 120-285/297.0
ELEENGVGYILNITKECDN------FFPERFKYCNIR---LY---------------------------------DDVEEDLLNHWNTTYLFLSKAKE--
 . |.|| .|...||....      ..||.  ...     |                                  |.   ..|..    . .. .| .  
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-AGSKALVHCKMGISRSASTVIAYAM-----KEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYE
  | . ||||..|..|... ..|| |     ||.|.... |..... .|. ..... ....|. ..
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
0043336 (Phosphotyrosine protein) phosphatases II 519-632 2.2e-14 49.1 In-house 108-272 (278) alignment 
Range on Protein: 519-632
Range on HMM: 108-272/278.0
LEENGVGYILNIT-----------------------------------------------KECDNFFPERFKYCNIRlYDDVEEDLLNHWNTTYLFLSKA
. |.||  |...|                                               ..   ..  .. | ..   ..| |.|  ...    .... 
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreal

KEAGSKALVHCKMGISRSASTVIAYAM-----KEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVY
.  ... ||||. |..|..  ...| .     ||.|..|| |..... .|  . ... ....|  .
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
0047943 (Phosphotyrosine protein) phosphatases II 519-629 9.9e-10 33.8 In-house 97-264 (273) alignment 
Range on Protein: 519-629
Range on HMM: 97-264/273.0
LEENGVGYILNITKECDN-------FFPERFK--------------------------------------------YCNIRlyddvEEDLLNHWNTTYLF
. |..| .|  .|.. ..       ..|.                                               | ..      . .   ...    |
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp.....dhgvppslesllef

LSKAKE------AGSKALVHCKMGISRSASTVIAYAM-----KEYGMTLEYALDFVKGKRSIIRPNDAFMKQL
. ....       ... .|||. |..|... .... .     ||.|.... |. ... .|  . ..  ....|
ielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 521-623 1.9e-08 29.6 In-house 114-272 (288) alignment 
Range on Protein: 521-623
Range on HMM: 114-272/288.0
ENGVGYILNITKE-------CDNFFP--------------------ERFKYCNIRL------------------------YDDVEEDLLNHWNTTYLFLS
|..| .|  .||.       |. ..|                    . ... ....                         ..| ...   ..   |. .
eqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrk

KAKEAGSKALVHCKMGISRSASTVIAYAM-----KEYGMTLEYALDFVKGKRSIIRPND
. .  |.  .|||. |..|..  .... .     ||.|.... |. ... .|  . .. 
alasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 521-620 9.8e-08 27.1 In-house 130-282 (308) alignment 
Range on Protein: 521-620
Range on HMM: 130-282/308.0
ENGVGYILNITKE-------CDNFFPERFK----YCNIRLYDDV-----------------------------------EEDLLNHWNTTYLFLSKAKEA
|..| .|  .||.       |. ..|.  .    ...      .                                   . .  ....    || .... 
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

--GSKALVHCKMGISRSASTVIAYAM-----KEYGMTLEYALDFVKGKRSIIR
  |.. .|||. |..|..  .... .     ||.|.... |. ... .|    
lpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmv
subfamily_MSG5_pd Subfamily MSG5 526-638 2.1e-14 47.0 In-house 50-162 (165) alignment 
Range on Protein: 526-638
Range on HMM: 50-162/165.0
YILNITKECDNF---FPErFKYCNIRLYDDVEedLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYAMKEYGMTLEYALDFVKGKRSIIRPN
 ..|..|| ...    |   ||  |.   | .  .    ..    .  |.  . | ||||. |.||||| ..|| || |...|. | | .|..   | |.
lvinvakeindlellvpa.vkyyhiewehdsk..ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddisps

DAFMKQLQVYEGILEA
  .. ||  .| .|..
iglifqlmewevalsk
subfamily_PTPMT1_pd Subfamily PTPMT1 538-634 1.9e-14 48.5 In-house 70-166 (171) alignment 
Range on Protein: 538-634
Range on HMM: 70-166/171.0
FPERFKYCNIRLYDDVEEDLLNHWNTTYLFLSKAKEAGSKALVHCKMGISRSASTVIAYAMKEYGMTLEYALDFVKGKRSIIRPNDAFMKQLQVYEG
  .  .. ...  |  |.  |.. . .  |..| .. |..  |||| | .|||. |..| ||.. ...| ||...| ||.||| ... .|.|| || 
kklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee
0046845 (Phosphotyrosine protein) phosphatases II 556-617 3e-06 22.3 In-house 186-254 (284) alignment 
Range on Protein: 556-617
Range on HMM: 186-254/284.0
DLLNHWNTTYLFLSKaKEAGSKALVHCKMGISRSASTVIAYAMKEY--------GMTLEYALDFVKGKRS
|||. ...   .|..  . |.. .|||. |..|..  .... ..|.        |.... |. ... .| 
dlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp
subfamily_CDC14_pd Subfamily CDC14 567-630 1.2e-06 22.7 In-house 255-320 (328) alignment 
Range on Protein: 567-630
Range on HMM: 255-320/328.0
FLSKAKEAGSKALVHCKMGISRSASTVIAYAMKEYGMTLEYALDFVKGKR--SIIRPNDAFMKQLQ
||. |..|  .. |||| |. |  . . .| ||.|..| . |. ...  |  |.| | . |... |
fleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfleekq