Gene STYXL1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily STYXL1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP028_AA protein Get Run
SpurP028_AA_155-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 43-134 1.1e-09 30.7 Pfam-A 12-112 (113) alignment 
Range on Protein: 43-134
Range on HMM: 12-112/113.0
NYLLLLDARQKNEYNESHILTSKRALR------------TADDKFLVPYGAEIECKMHVIVLDnnTSGLSKRDSPAFKCAKVMAEAGSRnPVRILRGGYE
. ..|||.|...||...||  .                     . |  .| ... . .|.| .   || . .   |. .|. ..|.|    |..|.||.|
ekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktvvvyc..rsgnrsggaaalllalilkelgyk.nvyvLdGGfe

EFSA
...|
awka
subfamily_MKPLT_pd Subfamily MKPLT 138-300 9.5e-28 90.8 In-house 1-161 (164) alignment 
Range on Protein: 138-300
Range on HMM: 1-161/164.0
FLRTQKILYMPQELDELRPYPVEVLPGQLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDglVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTE
|| |.. ..  ..  ... ||  ||. .||||| ..| .  | ||||.. .. ..|.  .        | .   ..|  .  . | | .| .|. . .  
fLitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp..ksveYlqvkvedesdeqlssfleraakfladaids

KNAVLVSSEHGISRSAAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIF
   |||    | |||... .|.|.   .|||..||..|.. .| ..| | |. ||.|.|| |.
GGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 138-300 9.5e-28 90.8 In-house 1-161 (164) alignment 
Range on Protein: 138-300
Range on HMM: 1-161/164.0
FLRTQKILYMPQELDELRPYPVEVLPGQLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDglVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTE
|| |.. ..  ..  ... ||  ||. .||||| ..| .  | ||||.. .. ..|.  .        | .   ..|  .  . | | .| .|. . .  
fLitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp..ksveYlqvkvedesdeqlssfleraakfladaids

KNAVLVSSEHGISRSAAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIF
   |||    | |||... .|.|.   .|||..||..|.. .| ..| | |. ||.|.|| |.
GGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_STYXL1_pd Subfamily STYXL1 148-302 4.4e-77 250.7 In-house 1-156 (157) alignment 
Range on Protein: 148-302
Range on HMM: 1-156/157.0
PQELDELRPYPVEVLPGQLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGLVG-AELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSE
|.|||||..||||||||.||||||.||..| .|||||||.......||..|..|... |.|.|....| ||||.|..|..|.|||.||..|...|||.|.
preldelktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsn

HGISRSAAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIFEE
.|||||||.|.|||||..|.||.||||.|..||.|..|.|.||.|||.||.....|
kGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllge
0044763 (Phosphotyrosine protein) phosphatases II 148-302 1.6e-27 91.7 In-house 13-173 (178) alignment 
Range on Protein: 148-302
Range on HMM: 13-173/178.0
PQELDELRPYPVEVLPGqLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGL-------VGAELMHCPLSDGNEADMLSQLSQACQFIGKHV-TEKN
....    ....|.||| ||||.. .|. .   |.|... .. .... |  . ..        | . .|.|..|... |.|... ....|| ... ....
eglersdyinaseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekgg

AVLVSSEHGISRSAAAILAYLMYHYKWTLQKAYKHLQNCKSnIRPHRDFVSQLSKWEEDIFEE
.|||   .|..||.. ..||||......|..|......... | |..... || ..|. ...|
pvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
subfamily_DSP10_pd Subfamily DSP10 148-301 3.9e-25 82.6 In-house 4-155 (159) alignment 
Range on Protein: 148-301
Range on HMM: 4-155/159.0
PQELDELRPYPVEVLPgQLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGlVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEH
|.| |      ..|||  |.||. ..| .  . . |... || ....     ..  . . .. |.|| .. ..  .  .| .|| .   . . |||  . 
pteadietapasqvlp.fLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqa

GISRSAAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIFE
||||||. ..||||.| . .|..|||. ..... | |  .|. || ..|... .
GisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
subfamily_DSP1_pd Subfamily DSP1 150-300 5e-25 82.5 In-house 8-157 (163) alignment 
Range on Protein: 150-300
Range on HMM: 8-157/163.0
ELDELRPY-PVEVLPGQLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGlvGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHG
.||.|. | ||| .   ||||  ..|    . |.|..  .| .... ..  .     | .. .|.| ..||. . .... .|| .  ...  ||.  . |
dldklklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaG

ISRSAAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIF
||||.. .||||| . ...|..|..  .. .| |.|   || || ..|... 
isRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0041856 (Phosphotyrosine protein) phosphatases II 151-300 7.6e-20 66.7 In-house 17-173 (182) alignment 
Range on Protein: 151-300
Range on HMM: 17-173/182.0
LdelrpYPVEVLPGqLYLGNYQQ--------------ACSPGVKKDLKVKGVLHIAqDAEELQDGLVG--AELMHCPLSDGNEADmlsqLSQACQFIGKH
.     .. ..... ||||.. .              |.     |.|... .. .. .     . |     .... |  |..  |    |.....|| . 
r.....dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieev

VTEKNAVLVSSEHGISRSAAAILAYLMYHYKWTLQKAYKHLQNCKS--NIRPHRDFVSQLSKWEEDIF
  |...|||   .|..|... ..||||......|..|.|.......   |.|.  |. ||  .|.  .
leeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 153-297 5.8e-25 81.5 In-house 2-145 (148) alignment 
Range on Protein: 153-297
Range on HMM: 2-145/148.0
ELRPYPVEVLPGQLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGLvGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRS
.|| .| |. .. |.||. ..| .  . |.| |  .   ... .   |   | | .|..|.| .. |. .   .. .|. |.. | . |||  . |.|||
aLrtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqr.gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrs

AAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
.|  |..|. . . .|..|.   .. .  ..|.  |..|| ..|.
salallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_DSP6_pd Subfamily DSP6 155-298 1e-26 87.4 In-house 11-153 (158) alignment 
Range on Protein: 155-298
Range on HMM: 11-153/158.0
RPYPVEVLPgQLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGLVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAA
. .|||.|| .||||. ..|.   | |.||.| || .... ..  .     . .. |..|  .... . . .| .|| .  ..|..|||    ||||| .
aefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

AILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEED
 .||||| ... .|..||. ... |||| |  .|. || ..|. 
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
0048179 (Phosphotyrosine protein) phosphatases II 156-297 2.5e-26 87.5 In-house 2-142 (144) alignment 
Range on Protein: 156-297
Range on HMM: 2-142/144.0
PYPVEVLPGqLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGLVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAA
..|.|.||| ||||..  |..    |.|... |. .. . |    .  | ...|.|. | .  |.|..| ....|| ... |.. |||   .|..|... 
snpseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtl

ILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
..||||......|..|....... ... |..... .| ..|.
vaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 156-298 3.8e-26 86.9 In-house 2-141 (145) alignment 
Range on Protein: 156-298
Range on HMM: 2-141/145.0
PYPVEVLPGqLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQdgLVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAA
..| |.||| ||||..  |..    |||... || .. . | |     | .....|. | .. |.|..| ....|| ... |.. |||   .|..|... 
ywpseilpg.lylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtl

ILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEED
..||||......|..|....... ... |. ... .| ..|. 
vaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0051429 (Phosphotyrosine protein) phosphatases II 156-302 3.2e-10 35.6 In-house 14-227 (272) alignment 
Range on Protein: 156-302
Range on HMM: 14-227/272.0
PYPVEVLPGQLYLGNYQ---QACSPGVKKDLKVKGVLHIAQDAEELQDG----LVGAELMHCPLSDGNEADML---------------------------
 |  .|.|| ||....     | .    |.|..| .. . .. |  ...    . |....|.|. |  . ..|                           
gygrvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltll

------------------------SQLSQACQFIGKhvteKNAVLVSSEHGISRSAAAILAYLMYhYKWT--------------LQKAYKHLQNCKSNIR
                        ..| .. ... .    ...|||   .|..|.. .....|.. . ..              |..|...|. .  ...
lsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgav

PHRDFVSQLSKWEEDIFEE
.. ... .| ... .....
qteeqylflyeallellrs
PTPc_motif_SM00404 158-297 7.1e-27 89.0 In-house 2-139 (140) alignment 
Range on Protein: 158-297
Range on HMM: 2-139/140.0
PVEVLPGqLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELqDGLVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAIL
| ..||. ||||....| .| ..| |... |. ...  .   .   | .....||.| ...... .|... .|| .  ... .|||   .|.||||. |.
psrilph.lylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatlii

AYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
||||. ....|..||. ... ...|.|   || || ..|.
aYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_LRR-DSP_pd Subfamily LRR-DSP 158-301 2.7e-17 56.7 In-house 120-260 (263) alignment 
Range on Protein: 158-301
Range on HMM: 120-260/263.0
PVEVLPGqLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGLVGAeLMHCPLSDGNEADMLSQLSQACQFIGKhVTEKNAVLVSSEHGISRSAAAIL
| |.... |.||  . |    . ||| |  .|    | | |   |    |.   . | .|||.   . .   || .   .|  |||    |.|||.....
Pdeiidk.lflGgldsannksilkdlgvthillavadfePlfPklfky.lsiddiedvdeadisqhfeetnafiee.GrkkGGvlvhcraGvsrsstlvi

AYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIFE
.||| . . ....|.   .. ...|.| . |. || |.|...| 
sylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
subfamily_MSG5_pd Subfamily MSG5 158-297 3.3e-16 52.8 In-house 26-158 (165) alignment 
Range on Protein: 158-297
Range on HMM: 26-158/165.0
PVEVLPGQLYLgnYqqaCSPGVKKDLKVKGVLHIAQDAEELQDGLVGAELMHCPLSdgNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAIL
|. ||| .|||  |     | .|. |    |. .|.....|.  .   .  |       .. .  .||.  . |    .... .||  . |.||||. |.
pllvlpeklyl..y...sepklkellsfdlvinvakeindlellvpavkyyhiewe..hdskivkdlsrltriihaatskrkkilvhcqcglsrsasliv

AYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
||.| .|. .|..||..|..   .| |   .. || .|| 
ayimkyynlslrdaydklksvaddispsiglifqlmewev
subfamily_DSP19_pd Subfamily DSP19 159-299 4.5e-22 73.0 In-house 12-150 (152) alignment 
Range on Protein: 159-299
Range on HMM: 12-150/152.0
VEVLPGQLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQdgLVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILA
| ..  .||||  . | .    |  |.  .| .| . ...       . .. .. | .|.|.||.|..| .|| .  ....||||  . |.||||. ..|
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvf..pkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvvia

YLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDI
||| . . .|..|.. ... . .|.|   |. || ..|. .
ylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP15_pd Subfamily DSP15 160-302 1.8e-15 51.3 In-house 4-142 (151) alignment 
Range on Protein: 160-302
Range on HMM: 4-142/151.0
EVLPGqLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGlvgAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILAY
.|||| |||||....      |. ..  .| . ..|..| .     |    ..||  .|.. . .... .|| |   ....|||    |.|||.  . ||
kvlpg.lylgnfrdskdeelLkeknithilsvhdnakkllkd...ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

LMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIFEE
||   .   ..| . .....|   |   | .|| ..|.   .|
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklke
subfamily_STYX_pd Subfamily STYX 160-297 6e-15 48.7 In-house 14-155 (166) alignment 
Range on Protein: 160-297
Range on HMM: 14-155/166.0
EVLPGqLYLGNYQQACSPGVkKDLKVKGVLHIAQDAEELQDGLVGAEL------MHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSA
|.||| |.|| |  |    . . || .|. ||    ....  |.  ..      .   ..|    ...  | .  .|| . . .   |||  . ||||||
eilpg.lflgpysaamkskl.evlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

AAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
| ..||.|  |    ..|....|. .  | |   ||||| ..| 
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0046846 (Phosphotyrosine protein) phosphatases II 162-297 4.5e-18 61.1 In-house 15-170 (176) alignment 
Range on Protein: 162-297
Range on HMM: 15-170/176.0
LPGQLYLGNYQ----------QACSPGVKKDLKVKGVLHIAQDAEELQDGL---------VGAELMHCPLSDGNEADMlSQLSQACQFIGKHVTEKNAVL
....|.||..            |      |.|... |. . .. |  . ..         .| . .|.|  |..  |. ..| ....|| ....|.. ||
inanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvl

VSSEHGISRSAAAILAYLMYH-YKWTLQKAYKHLQNCKS-NIRPHRDFVSQLSKWEE
|   .||.|... ..|||... . .....|......... .. ...... .| ..| 
VHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
0042113 (Phosphotyrosine protein) phosphatases II 162-296 4.4e-16 54.5 In-house 50-239 (245) alignment 
Range on Protein: 162-296
Range on HMM: 50-239/245.0
LPGQLYLGNYQQACSPG----VKKDLKVKGVLHIAQDAE--------------------------------------------ELQDGLVGAELMHCPLS
 ......... .. ...      ..|... .. . .. |                                                 . .  ... |  
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

DGNEADMLSQLSQACQFIGKHVT--EKNAVLVSSEHGISRSAAAILAYLM-----YHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWE
|....|.|..| ....|. |..   ... ||| . .|..|... |.||||     ......|..|.|.|.........  ..  .| ...
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0051082 (Phosphotyrosine protein) phosphatases II 162-281 3.4e-12 41.7 In-house 11-134 (151) alignment 
Range on Protein: 162-281
Range on HMM: 11-134/151.0
LPGQLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGLV----GAELMHCPLSDGNEADMLSQLSQACQFIGKHVTE-KNAVLVSSEHGISRSAAAI
. | ||....  |      |.|..| .. . .. |   .       | |..|.|. |  . ..   . .. .|. .     .. |||   .|..|... .
vtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

LAYLMYhYKWTLQKAYKHLQNCKSN
..|||. ....|..|..... .  .
alylml.lgvsleealeeyrlkrpg
PTEN_1 163-297 9.8e-14 46.6 In-house 45-189 (196) alignment 
Range on Protein: 163-297
Range on HMM: 45-189/196.0
PGQLYLGNYQQA-CSPGVKKDLKVKGVLHIAQDAEE----LQDG---LVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVT--EKNAVLVSSEHGISRS
...||.|.. .. .    .|  .. .|.  . . |.     ..      | |  |.|  | .  .. . .  ...||       ..|.|||   .|..||
deglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRs

AAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
.  . |||||..|.| ..| .... . ....|.  .  .| . ..
GtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfa
subfamily_DSP12_pd Subfamily DSP12 164-297 6.7e-30 98.5 In-house 7-141 (155) alignment 
Range on Protein: 164-297
Range on HMM: 7-141/155.0
GQLYLGNYQQACSPGVKKDLKVKGVLHIAQDA-EELQDGLVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILAYLMY
..||||. ... ..  .|.||.. || ... . .| ..     .  . .. | .|.|.|| | .|..|| . . |..||||  . |.|||.....||||.
pglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmk

HYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
..|. |.||.| ... |..|.|   |..||  .|.
keklslekAlklvkekkpeiepNegFleQLklfek
subfamily_DSP8_pd Subfamily DSP8 164-300 5.1e-24 78.6 In-house 20-155 (159) alignment 
Range on Protein: 164-300
Range on HMM: 20-155/159.0
GQLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEElQDGLVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILAYLMYH
 .||||  ... |  . ..| .  || . .   . .. |  ......|. | .. ..|  . ....|| | ..|.  |||    ||||||. ..||.| .
knlylGsqkdvlseellsklgisyvlnasnscpk.leelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimkt

YKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIF
 . .|..||..... .  | |   |. || ..|... 
lemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_DSP14_pd Subfamily DSP14 165-306 2.8e-22 73.4 In-house 13-151 (157) alignment 
Range on Protein: 165-306
Range on HMM: 13-151/157.0
QLYLGnYQQACSPGVKKDLKVKGVLHIAQdaEELQDGLVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILAYLMYHY
.|.|.  . | |. . |  |.  .. ...  |  .  | . | .. |..| .||.. . . .... | .  ... ..||    |.||||.  ||||| . 
sLfls.gvaalskellkkkkitliinvtv..elpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkye

KWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIFEEGVQT
| .|..|||....... |||   | .|| ..|. ....  . 
klsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvk
subfamily_Slingshot_pd Subfamily Slingshot 165-296 2.3e-21 69.9 In-house 25-154 (169) alignment 
Range on Protein: 165-296
Range on HMM: 25-154/169.0
QLYLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDGLVgaELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILAYLMYHY
 .|||    |.     |. .|. .| .... ..  .. .  | ..  . | .|.|.|..  .. .|| |  ...  |||    |.||||....|| | .|
hvylGsewnasnleelkengveyilnvtkeidnffpekf..eylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkey

KWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWE
...|..|...... .| |.| . |..||...|
glsleealeyvkerrsvikPnkgflkqleeye
subfamily_DSP3_pd Subfamily DSP3 165-300 2.1e-17 57.3 In-house 17-158 (162) alignment 
Range on Protein: 165-300
Range on HMM: 17-158/162.0
QLYLGNYQQACSpgvKKDLKVKGVLHIAQDAEE-L------QDGLVGA--ELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKN-AVLVSSEHGISRSAA
.||.|. . |     |. ||  |. |.   ||  .      ..   ..  . .  ...|  |.|.    ..| .|| . ...|.  |||... |.||||.
klyvgdeavakd...kskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

AILAYLMYHYKWTLQKAYKHLQNcKSNIRPHRDFVSQLSKWEEDIF
 .||||| . | ||..| .. .. | .|.| . |. || . .|.. 
lvlayLmirrkmtlveairtvrk.kReilPneGFlkqLaeldeelk
0037934 (Phosphotyrosine protein) phosphatases II 165-296 8.4e-14 47.2 In-house 45-238 (243) alignment 
Range on Protein: 165-296
Range on HMM: 45-238/243.0
QLYLGNY--------QQACSPGVKKDLKVKGVLHIAQDAEE-------------------------------------------LQDGLVGAELMHCPLS
.|.....          |      ..|... .. . .. |                                             .  . .  ... |  
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

D----GNEADMLSQLSQACQFIGK-----HVTEKNAVLVSSEHGISRSAAAILAYLMYHY-KWTLQKAYKHLQNCKSN-IRPHRDFVSQLSKWE
|     . .|.|. |.....|| .     .  ... |||   .|..|... |.||||... ...|..|.|.|...... . . ...  .| ...
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
DSPc Dual specificity phosphatase, catalytic domain 166-297 1.5e-24 81.4 Pfam-A 1-132 (133) alignment 
Range on Protein: 166-297
Range on HMM: 1-132/133.0
LYLGNYQQACsPGVKKDLKVKGVLHIAQDAEE-LQDGLVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILAYLMYHY
||||....|  . ....|... |. ...  ..  ..     | ...|. | .|... ..|..| .|| |  .... |||  ..||||||. |.||||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

KWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
...|..||..... .|.|.|   |. || ..|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 166-297 1.5e-24 81.4 In-house 1-132 (133) alignment 
Range on Protein: 166-297
Range on HMM: 1-132/133.0
LYLGNYQQACsPGVKKDLKVKGVLHIAQDAEE-LQDGLVGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILAYLMYHY
||||....|  . ....|... |. ...  ..  ..     | ...|. | .|... ..|..| .|| |  .... |||  ..||||||. |.||||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

KWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
...|..||..... .|.|.|   |. || ..|.
nlslneAyefvkerrskispnagflrqLleyer
0049260 (Phosphotyrosine protein) phosphatases II 167-297 1.3e-14 49.6 In-house 16-147 (152) alignment 
Range on Protein: 167-297
Range on HMM: 16-147/152.0
YLGNYQQACSPGVKKDLKVKGVLHIAQDAEELQDG-LVGAELMHCPLSDGNEADMLSQLSQACQFIGK-HVTEKNAVLVSSEHGISRSAAAILAYLMYhY
..|..  |      |.|... .. . .. |   ..   . . .|.|  |..  |.   | ....|| |    ... |||   .|..|... ..||||. .
gpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.l

KWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
...|..|........... |. ..  .| ..|.
gvsleeavalvrekRpgavpnpgqlrflyefek
0036282 (Phosphotyrosine protein) phosphatases II 167-296 2e-14 49.1 In-house 20-166 (174) alignment 
Range on Protein: 167-296
Range on HMM: 20-166/174.0
YLGNYQQAcSPGVKKDLKVKGVLHIAQDAEE-------------LQDGLVGAELMHCPLSDGNEADMLSqLSQACQFIGKHVTE--KNAVLVSSEHGISR
..|..  |      |.|... |.   .  |                    | .....|  |... |.   | ....|. ... |  .. |||   .|..|
iagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgR

SAAAILAYLMYHYKW-TLQKAYKHLQNCK---SNIRPHRDFVSQLSKWE
... ..||||..... .|..|..... ..   ... .. ..  .| ..|
tGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
0043147 (Phosphotyrosine protein) phosphatases II 169-297 6.7e-16 54.0 In-house 29-158 (172) alignment 
Range on Protein: 169-297
Range on HMM: 29-158/172.0
GNYQQACSPGVKKDLKVKGVLHIAQD-AEELQDGLVGAELMHCPLSDGNEAdMLSQLSQACQFIGK--HVTEKNAVLVSSEHGISRSAAAILAYLMYhYK
...  |      |.|... .. . .      .    | .....|  |..   .|..| ....|| .  .. ....|||   .|..|... ..||||. ..
lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lg

WTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
..|..|........... .. ..  .| ..|.
lsleeavalvrekRpgavqnpsqyrflyyfek
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 184-289 3.3e-06 17.4 Pfam-A 318-429 (451) alignment 
Range on Protein: 184-289
Range on HMM: 318-429/451.0
KVKGVLHIAQDAEELQDGLVGAELMHCPLSDG--NEADMLSQLSQACQFIGKHVTE--KNAVLVSSEHGISRSAAAILAYLMYHYK--WTLQKAYKHLQN
.|. |... .   . ..    .. .. .|...  .. .. ..| ....|| .....  .. .|| .|.|   |....|| |  ...  ..|.|  .. . 
evdlvislsekivsseteekkkkvlelklesskkgskeLrkalpkieefiksklsseknkkilvlcesGkdlsvgvvlailclyfdeegklkkseeekki

CKSNIRPHRDFV
 |. || .  ..
nkelirkrlall
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 194-298 1.8e-19 63.6 In-house 46-151 (154) alignment 
Range on Protein: 194-298
Range on HMM: 46-151/154.0
DAEELQDGLVgAELMHCPLSDGNEADMLSQLSQACQFIGKHV--TEKNAVLVSSEHGISRSAAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQ
.  ...||..  | ..  | |  . |.. .|..| .|| . .   |.| ||| |..|.||||| ...||| . | .| .|.. |....  |.| . |. |
ensdindgfi.ieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkq

LSKWEED
| ..| .
leifeke
subfamily_PTPMT1_pd Subfamily PTPMT1 198-299 1.1e-14 49.3 In-house 72-168 (171) alignment 
Range on Protein: 198-299
Range on HMM: 72-168/171.0
LqdglvGAELMHCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEE
|     | | .. .  |  ||  | .|... .|| |. .... | |  . | .|||. . .|||...|.....| |.|..... || ..  ...|...||
l.....gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee

DI
 .
kl
0049772 (Phosphotyrosine protein) phosphatases II 203-298 1.8e-22 75.9 In-house 179-272 (314) alignment 
Range on Protein: 203-298
Range on HMM: 179-272/314.0
VGAELMHCPLSDgNEADMLSQLSQACQFIGKHvTEKNAVLVSSEHGISRSA-AAILAYLMYHYKWTLQKAYKHLQNCKSnIRPHRDFVSQLSKWEED
 | .....|..| ..|. |... ....|| ..  ....|||   .|..|.. ....||||......|..|....... . |.|.. |. ||  .|. 
lgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi
0045098 (Phosphotyrosine protein) phosphatases II 204-301 1.1e-15 53.2 In-house 155-273 (278) alignment 
Range on Protein: 204-301
Range on HMM: 155-273/278.0
GAELMHC-PLSDGNEADML--SQLSQACQFIGKHVT--------------EKNAVLVSSEHGISRSAAAILAYLMYHY---KWTLQKAYKHLQNCKSN-I
| . .|. |  |..  ..   ... ....|| ...               ... |||   .|..|... ..||||...   ...|..|.|.|.... . .
gvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpgla

RPHRDFVSQLSKWEEDIFE
 .. ..  .| ... ....
vqnleqyrflyefllelll
0038934 (Phosphotyrosine protein) phosphatases II 204-301 1e-13 46.8 In-house 79-178 (194) alignment 
Range on Protein: 204-301
Range on HMM: 79-178/194.0
GAELMHCPLSDGNEADMLSQLSQACQFIGKHVTE--KNAVLVSSEHGISRSAAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIFE
| | ...|  | ...  |..| . .... ... |  ...|.|   .|..|..  . |||.|........|..... .. .. |..|....| |. .....
gieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk
0040439 (Phosphotyrosine protein) phosphatases II 205-296 5.7e-13 44.5 In-house 140-242 (249) alignment 
Range on Protein: 205-296
Range on HMM: 140-242/249.0
AELMHCPLSDGNEADMLSQLSQACQFIGKHVT------EKNAVLVSSEHGISRSAAAILAYLM-----YHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLS
 . .| .  |  . .  . ......|| .  .      ... ||| . .|..|... |.||||     ......|. |.|.|....... .  ..  .| 
rtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfly

KWE
...
eal
0039614 (Phosphotyrosine protein) phosphatases II 209-296 1.6e-12 43.0 In-house 190-285 (297) alignment 
Range on Protein: 209-296
Range on HMM: 190-285/297.0
HCPLSDGNEADMLSQLSQACQFIGKHVT---EKNAVLVSSEHGISRSAAAILAYLM-----YHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWE
. .  |..  . |..| ...... ...    ... ||| . .|..|... |.||||     .........|.|.|.........  ..  .| ...
ytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
0045450 (Phosphotyrosine protein) phosphatases II 209-297 2e-12 43.0 In-house 199-301 (307) alignment 
Range on Protein: 209-297
Range on HMM: 199-301/307.0
HCPLSDGNEADMLSQLSQACQFIGKHVT------EKNAVLVSSEHGISRSAAAILAYLMYHYK--------WTLQKAYKHLQNCKSNIRPHRDFVSQLSK
| .  .  . .  . ......|| .  .      ... ||| . .|..|... |.||||...         ..|..|.|.|....... .  ..  .| .
hfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye

WEE
.. 
all
0043336 (Phosphotyrosine protein) phosphatases II 209-295 3.9e-10 35.1 In-house 180-272 (278) alignment 
Range on Protein: 209-295
Range on HMM: 180-272/278.0
HCPLSDGNEADMLSQLSQACQFIGKHVT-EKNAVLVSSEHGISRSAAAILAYLM-----YHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKW
. .  |..  . ||.| . .... ...  ....||| . .|..|... |..||.     ......|..|.|.|.... .. .  ..  .| ..
ylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_Laforin_pd Subfamily Laforin 209-275 1e-06 21.7 In-house 81-147 (183) alignment 
Range on Protein: 209-275
Range on HMM: 81-147/183.0
HCPLSDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILAYLMYHYKWTLQKAYKHL
  |. |      . .| ||  ..   . .   | |  . |. ||.|..  .|.|  .|.|.|   .|
wlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfl
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 213-299 1.9e-06 21.0 In-house 55-141 (145) alignment 
Range on Protein: 213-299
Range on HMM: 55-141/145.0
SDGNEADMLSQLSQACQFIGKHVTEKNAVLVSSEHGISRSAAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDI
.| .  |.   . .  .|| |   |   |.|    |.||| .  .|.|| . . || .| . ..  .    |   |. .| . | ..
edlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekql
0047943 (Phosphotyrosine protein) phosphatases II 214-290 1.3e-07 26.8 In-house 178-262 (273) alignment 
Range on Protein: 214-290
Range on HMM: 178-262/273.0
DGNEADMLSQLSQACQFIGKHVT---EKNAVLVSSEHGISRSAAAILAYLM-----YHYKWTLQKAYKHLQNCKSNIRPHRDFVS
| .  . |..| . .... |.     ... |.| . .|..|... |...|.     ....... .|.|.|.... .. .  ..  
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr
0050432 (Phosphotyrosine protein) phosphatases II 216-282 3.8e-06 21.9 In-house 211-281 (308) alignment 
Range on Protein: 216-282
Range on HMM: 211-281/308.0
NEADMLSQLSQACQFIGKHVtEKNAVLVSSEHGISRSAAAILAYLM-----YHYKWTLQKAYKHLQNCKSNI
.  . ...| . .... |.  ... ..| . .|..|... |...|.     .........|.|.|  .. . 
gvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm
0036941 (Phosphotyrosine protein) phosphatases II 219-301 7e-11 37.4 In-house 182-278 (297) alignment 
Range on Protein: 219-301
Range on HMM: 182-278/297.0
DMLSQLSQACQFIGKHVT------EKNAVLVSSEHGISRSAAAILAYLM--------YHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIFE
.. .  ..  .|| .  .      ... ||| . .|..||.. |.|.||        ....... .|.|.| ... .. .  ..  .|  .. . . 
gvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0040438 (Phosphotyrosine protein) phosphatases II 221-300 3.7e-11 38.3 In-house 188-276 (317) alignment 
Range on Protein: 221-300
Range on HMM: 188-276/317.0
LSQLSQACQFIGKHVTE----KNAVLVSSEHGISRSAAAILAYLM-----YHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWEEDIF
 . ...  .|. .  .     .. ||| . .|..|... |.||||     .........|.|.|....... .  ..  .| ... ...
ppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0046845 (Phosphotyrosine protein) phosphatases II 222-281 2.7e-06 22.5 In-house 185-255 (284) alignment 
Range on Protein: 222-281
Range on HMM: 185-255/284.0
SQLSQACQFIGKH---VTEKNAVLVSSEHGISRSAAAILAYLMYHY--------KWTLQKAYKHLQNCKSN
..| . .... ..   .  .. ..| . .|..|... |...|....        ......|.|.| ... .
edlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
0051299 (Phosphotyrosine protein) phosphatases II 224-284 4.4e-06 21.8 In-house 204-270 (288) alignment 
Range on Protein: 224-284
Range on HMM: 204-270/288.0
LSQAC-------QfigkhvTEKNAVLVSSEHGISRSAAAILAYLM-----YHYKWTLQKAYKHLQNCKSNIRP
| . .       .        .. |.| . .|..|... |...|.     ....... .|.|.| ... .. .
lldflrlvrkala......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvq
0048567 (Phosphotyrosine protein) phosphatases II 228-296 1.5e-08 29.1 In-house 64-135 (157) alignment 
Range on Protein: 228-296
Range on HMM: 64-135/157.0
CQFIGKHVTEKNAVLVSSEHGI---SRSAAAILAYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKWE
 .|..    ...|. | . .|    .|.|  | .||..|...| ..|...|. .  .. |.||    ||...
nkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn
DSPn Dual specificity protein phosphatase, N-terminal half 236-295 8.6e-06 16.5 Pfam-A 66-127 (141) alignment 
Range on Protein: 236-295
Range on HMM: 66-127/141.0
TEKNAVLVSSEHGISRSAAAIL--AYLMYHYKWTLQKAYKHLQNCKSNIRPHRDFVSQLSKW
..|. ||..|..   |. ||.|  ||.. . |.. ..|.| |.. . .. | ||   . |..
kkkkivlytsldekkranaalLigaYavivlklspeealkplesvepsllpFrDAsygesty