Gene MTMR6 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR6
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP036_AA protein Get Run
SpurP036_AA_135-455 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myotub-related Myotubularin-like phosphatase domain 118-211 4.4e-24 77.9 Pfam-A 1-96 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 118-211 4.4e-24 77.9 In-house 1-96 (353) alignment
subfamily_MTMR6_pd Subfamily MTMR6 119-212 4.2e-41 133.5 In-house 1-94 (397) alignment 
Range on Protein: 119-212
Range on HMM: 1-94/397.0
LYAFHYKSATVVPTMVTGWDQFDLQAEYARMGIPNAHWCSTAINKNYEICDTYSRTLYVPTHASPPVLVGSSRFRSRGRLPVLSYLHQENNKRL
||||.||...   ..|.||...||.|||.|||.||..|..|..||.||.||||.|.||||..|.  ||||||.|||.||||||||||.||....
lyafsykpkkdkeekvsGwklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaai
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 120-212 5.6e-22 70.5 In-house 1-92 (404) alignment 
Range on Protein: 120-212
Range on HMM: 1-92/404.0
YAFHYKSATVVPTmvTGWDQFDLQAEYARMGIPNA-HWCSTAINKNYEICDTYSRTLYVPTHASPPVLVGSSRFRSRGRLPVLSYLHQENNKRL
.||.|.    | .   ||  .| . ||.|.||..  .|  . ||..||.|.|| ..| ||.. |   |. .. |||.||.||||. |...|  .
fafsysekksvle..dgwliydaeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknsti
subfamily_MTMR9_pd Subfamily MTMR9 122-210 7.2e-18 56.8 In-house 2-88 (393) alignment 
Range on Protein: 122-210
Range on HMM: 2-88/393.0
FHYKSAtvVPTMVTGWDQFDLQAEYARMGIPNAHWCSTAINKNYEICDTYSRTLYVPTHASPPVLVGSSRFRSRGRLPVLSYLHQENNK
| |.|   . .. .|...|| . |.|..  .  .|  . .|||...| .|  .. ||   .   |. |..||. ||.|||||||.|.. 
ffyrsv..atiledgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketka
0040695 (Phosphotyrosine protein) phosphatases II 133-452 2.7e-110 362.6 In-house 4-386 (388) alignment 
Range on Protein: 133-452
Range on HMM: 4-386/388.0
MVTGWDQFDLQAEYARMGIPNAHWCSTAINKNYEICDTYSRTLYVPTHASPPVLVGSSRFRSRGRLPVLSYLHQENNKRLRGRVTFDV------------
.. ||  .|   |. |.|... .|. . .|.|||.|..| . |.||...| ..|. ..||||.||.||||| |..|.. |    .. |            
leegwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledek

-----------------------------------------------------NQNLALEILRPLSDNFsLKNPSMEAFLSGLESSQWMKHIKAVLDTSL
                                                     | .   | |  | |.. |..|..  .|| ||.|.|...|| .|... 
lleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac.lnvpdslnllslleesgwldliklilelav

FIAKAIADEGLSVLVHCSDGWDRTAQTCSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHRCGLLAY--DPREVSPVFTQFIECTWQLCQQFPCAFQF
.|.| . ... |||||||||||||.| .||| ..|||||||. |||||||||||.|||||..|.|.|    |. |.|||| .|..|.||| .|||.||.|
livklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeF

NERFLLELHDHVFSSQFGNFLGNCERERQDKKLSQKTFSLWQYMQARMSDYINPLYKANHPSangILKPNFSPQMLKFWRGMYNRYE
|||.|| |.||..|..||.||.|.|.|| . ..|..|.|||.|.. | |...||||. ..     .|.|..|.. |..| ..|.|. 
nerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYdpssle...vllpslsvldlllWleyylrwl
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 133-210 4.8e-10 30.7 In-house 12-96 (405) alignment 
Range on Protein: 133-210
Range on HMM: 12-96/405.0
MVTGWDQFDLQAEYARMGIP-------NAHWCSTAINKNYEICDTYSRTLYVPTHASPPVLVGSSRFRSRGRLPVLSYLHQENNK
.. ||. .. . ||.|. |        |..|  |.|||.|..| .|| .| | ..|    |     |||.||.| ||.   . | 
sidgwevynqkkeylrfniyideenssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssna
subfamily_MTMR1_pd Subfamily MTMR1 134-211 1.1e-23 76.1 In-house 4-82 (389) alignment 
Range on Protein: 134-211
Range on HMM: 4-82/389.0
VTGWDQFDLQAEYARMGIPNA-HWCSTAINKNYEICDTYSRTLYVPTHASPPVLVGSSRFRSRGRLPVLSYLHQENNKR
  ||. .| .||. |.|..|. .|  | .||.||.||||...|.||. .|  .| ....|||.|||||||.|..||.  
edGWkvydpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqav
subfamily_pats1_pd Subfamily pats1 137-212 2.8e-06 18.0 In-house 6-80 (691) alignment 
Range on Protein: 137-212
Range on HMM: 6-80/691.0
WDQFDLQAEYARMGIPNAH-WCSTAINkNYEICDTYSRTLYVPTHASPPVLVGSSRFRSRgRLPVLSYLHQENNKRL
.|.. |  |. |...   . |  . .  . .... | ..  ||   |  .|| . | ||  ..||||. .|.|   |
fdiyslliegqrlkldldkdwrvvefl.srdlseiyPkrilvPklvsdellvsyvrkrss.kiPvlswsnqnnkssl
subfamily_MTMR3_pd Subfamily MTMR3 140-209 1.3e-11 36.9 In-house 27-97 (442) alignment 
Range on Protein: 140-209
Range on HMM: 27-97/442.0
FDLQAEYARMGI-PNAHWCSTAINKNYEICDTYSRTLYVPTHASPPVLVGSSRFRSRGRLPVLSYLHQENN
 .|..|..|.|   . .|  . .|.....| .| ..| ||.. .   |  ...||| .|||.. . |..| 
eklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkng
subfamily_MTMR5_pd Subfamily MTMR5 145-209 4.7e-06 17.7 In-house 13-84 (483) alignment 
Range on Protein: 145-209
Range on HMM: 13-84/483.0
EYARMGIPN-------AHWCSTAINKNYEICDTYSRTLYVPTHASPPVLVGSSRFRSRGRLPVLSYLHQENN
.| |.|. .        ..  ...||.|..|..|   . ||.. |   .   ..   ..||||  . |. |.
dykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernk
subfamily_MTMR9_pd Subfamily MTMR9 231-451 8.1e-72 234.4 In-house 171-392 (393) alignment 
Range on Protein: 231-451
Range on HMM: 171-392/393.0
PLSDNFSLKNPSMEAFLSGLESSQWMKHIKAVLDTSLFIAKAIADEGLSVLVHCSDGWDRTAQTCSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHR
 | .  | .. |.. ||| ||.|.|.......|...| .|... .|| .|.|| ..| | | |  ||| .||||..||..||. |||.||.  || | .|
klleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasR

CGLLAYDP---REVSPVFTQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDKKLSQKTFSLWQYMQ--ARMSDYINPLYKANh
.  .|. .   .. .|||  |..| .|. .|||..| |||..|  |. | .|||||.||...|.||...||..|| |||.|..  .......||||.|| 
askvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyean.

psaNGILKPNFSPQMLKFWRGMYNRY
   . .. |.  ||.|..|...| |.
...aeviwpsvapqslelWselylrw
subfamily_MTMR6_pd Subfamily MTMR6 232-453 1.2e-118 388.9 In-house 178-397 (397) alignment 
Range on Protein: 232-453
Range on HMM: 178-397/397.0
LSDNFSLKNPSMEAFLSGLESSQWMKHIKAVLDTSLFIAKAIADEGLSVLVHCSDGWDRTAQTCSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHRC
| .   ||..|...||||||||.|.||||||||.|.|||||.|.|| |||||||||||||||.|||||..||||||||.||.||||||||.||||| .||
llevvelksksvseflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfserc

GLLAYDPREVSPVFTQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDKKLSQKTFSLWQYMQARMSDYINPLYKANHPSanGI
|||  |..||||.||||.||.|||..|||.||.|||||||||||||.|.|||.||||||..|.|.||...|.|||.|...| .||.||||||.. .  ..
GlldedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayllerkddylnplykaetek..ev

LKPNFSPQMLKFWRGMYNRYEN
|||. .|..||.||..|||...
lkpdtapaalklwralynrfdk
subfamily_MTMR5_pd Subfamily MTMR5 235-445 9.2e-55 178.3 In-house 255-476 (483) alignment 
Range on Protein: 235-445
Range on HMM: 255-476/483.0
NFSLKNPSMEAFLSGLESSQWMKHIKAVLDTSLFIAKAIADEGLSVLVHCSDGWDRTAQTCSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHRCGLL
... .......||. .| |.|.. |...|. |  ... .  .| ||||   |||| |||  ||| ..|||||||..||.||.|||||||||.| .|. . 
staveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqt

A-YDPREVSPVFTQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDKKL----------SQKTFSLWQYMQAR---MSDYINPL
       ..||| ||..| .|. .||| || ||. .|  |  |  | .|  || ..| || .. |           . . |.|.|....    . . | |
lsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakkagksvwdyidrqhkrspifynfl

YKanhPSANGILKPNFSPQMLKFWR
|.   |. . .|.|. .   || | 
ys...pdesevlrPssnvsslkvWd
Myotub-related Myotubularin-like phosphatase domain 237-395 1.8e-76 250.2 Pfam-A 191-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 237-395 1.8e-76 250.2 In-house 191-352 (353) alignment
subfamily_MTMR3_pd Subfamily MTMR3 240-449 1.5e-75 247.7 In-house 232-440 (442) alignment 
Range on Protein: 240-449
Range on HMM: 232-440/442.0
NPSMEAFLSGLESSQWMKHIKAVLDTSLFIAKAIADEGLSVLVHCSDGWDRTAQTCSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHRCGLLA--YD
 |    .|| ||. .|....  .| ... ...|.  || .||||||||||||.|  .|| ..|||||||..||.||.|.|||.|||||  |||      |
spdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvdd

PREVSPVFTQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDKKLSQKTFSLWQYMQARMSDYINPLYKANhpsANGILKPNFS
  | .||| |....  || .|||..|.||| ||. |  | .|. || ||.|.|.||...|. ..|.|.|....|.  .| | ||| .   .. .| |..|
anercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekvkertlsvWsllrakekeyrnllykek...teavllpavs

PQMLKFWRGMYN
 . ||.|. .| 
vrelklwsevyl
subfamily_MTMR1_pd Subfamily MTMR1 242-452 8.4e-85 277.4 In-house 177-387 (389) alignment 
Range on Protein: 242-452
Range on HMM: 177-387/389.0
SMEAFLSGLESSQWMKHIKAVLDTSLFIAKAIADEGLSVLVHCSDGWDRTAQTCSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHRCGL--LAYDPR
. . .|| |||..|..|||..|...  |....  |  |||||||||||||||  ||| ..||.|||||.||.||||||||.||||| .| |     . ..
ddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssda

EVSPVFTQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDKKLSQKTFSLWQYMQARMSDYINPLYKANHPsaNGILKPNFSPQ
| |||| |||.| ||| .|||.||.|||.||. | ||. |. ||.|| |.|.||...|...|| ||| |.........||||. .    . .| |..| .
ersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyaeele..kkvlypkaslr

MLKFWRGMYNRYE
.|. |.  | |..
rlelWkeyylrwn
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 242-452 1.2e-79 260.3 In-house 187-403 (404) alignment 
Range on Protein: 242-452
Range on HMM: 187-403/404.0
SMEAFLSGLESSQWMKHIKAVLDTSLFIAKAIADEGLSVLVHCSDGWDRTAQTCSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHRCGL-LAYDPRE
. . .|| ||||.|. ||| .| .|  |.. | .|. |||||||||||||.| .||. ..||||||||.||.|||||||| ||||| .|.|    ..  |
keknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigqttekssde

VSPVFTQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDKKLSQKTFSLWQYMQARMSDYINPLYKAN-HPSANGILKPN----
 ||.| |||.| .|| .|||  |.|||.||... |.. |..||.|| ..|.|||...| ..| ||| ...|  |.|.|||| .. . . . | . .    
rsPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleankseylnplyilekkeqkenitssessss

FSPQMLKFWRGMYNRYE
 .....|.|. .| |..
adikliklWseyylrwr
subfamily_pats1_pd Subfamily pats1 242-331 3e-21 67.5 In-house 366-457 (691) alignment 
Range on Protein: 242-331
Range on HMM: 366-457/691.0
SMEAFlSGLESSQWMKHIKAVLDTSLFIAKAIaDEGLSVLVH-CSDGWDRTAQT---CSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHRC
|.... . .| |.|.  .| .|.... ... . ||| |||..  .|. . . .     ||| ...||.|||. ||.|||||||| .|. | ...
sddew.keieeskwvdsvkllleaavkvsnll.deGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfskin
subfamily_MTMR10_pd Subfamily MTMR10 244-422 3.6e-50 162.8 In-house 153-331 (380) alignment 
Range on Protein: 244-422
Range on HMM: 153-331/380.0
EAFLSGLESSQWMKHIKAVLDTSLFIAKAIADEGLSVLVHCSDGWDRTAQTCSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHRCGLLAYDPREVSP
. .|| ||...|.. ....| |.  ..|...... ||..  |.| |     .|||...|||.||||.||| ||.||| | ||.||.|.| .. .. . ||
dkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksesp

VFTQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDKKLSQKTFSLWQYMQARMSDYINPLYK
||  | .|..|| .||| .|.|.|.||. |.|...|. |..|| |.|..|. .. |.. . . .. . . . . . |..
vfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsssplliakselkendllkdeldy
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 246-452 6.5e-63 204.9 In-house 203-405 (405) alignment 
Range on Protein: 246-452
Range on HMM: 203-405/405.0
FLSGLESSQWMKHIKAVLDTSLFIAKAIAdEGLSVLVHCSDGWDRTAQTCSLASIILDPYYRTIQGFQVLIEKEWLAFGHKFLHRCGLLAYDPREVSPVF
|   .| . |. |||..|... | |. |   | |.||||||||||| |  ||. |.||||||||.|||||||||||.|||||  | | |  .  | ||.|
fwgyieetgwishiksileaatfsaelil.kgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgneeerspif

TQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDKKLSQKTFSLWQYMQARMSDYINPLYKanhPSANGILKPNFSPQMLKFWR
 ||..| .||..|||  |.|   .|| . | . | ..| || |||..| ....  || |.|  ..  .  ..|| |.   |     .||..  . |..|.
qqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyyn...pqdiqsikpklysrclelwk

GMYNRYE
  | |.|
acymrve
0045098 (Phosphotyrosine protein) phosphatases II 260-303 1.7e-06 23.1 In-house 176-232 (278) alignment 
Range on Protein: 260-303
Range on HMM: 176-232/278.0
KAVLDTSLFIAKAI-------------ADEGLSVLVHCSDGWDRTAQTCSLASIILD
| .|.   || .|.              |.|  |||||| |..||.  . .  ..  
ksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlel
0044763 (Phosphotyrosine protein) phosphatases II 261-297 8.2e-06 21.1 In-house 94-130 (178) alignment 
Range on Protein: 261-297
Range on HMM: 94-130/178.0
AVLDTSLFIAKAIADEGLSVLVHCSDGWDRTAQTCSL
 .|..  || .|....|  |||||| |..|..  . .
hflefvefieealdekggpvlVHCsaGvgRsgtlvaa
0049772 (Phosphotyrosine protein) phosphatases II 263-293 9.2e-06 21.1 In-house 200-228 (314) alignment 
Range on Protein: 263-293
Range on HMM: 200-228/314.0
LDTSLFIAKAiaDEGLSVLVHCSDGWDRTAQ
..   || .|  |.|  |||||..|..||. 
deflefieea..dkggpvlvHCkaGkgRtgt
0051429 (Phosphotyrosine protein) phosphatases II 264-305 1.3e-06 23.8 In-house 138-178 (272) alignment 
Range on Protein: 264-305
Range on HMM: 138-178/272.0
DTSLFIAKAIADeGLSVLVHCSDGWDRTAQTCSLASIILDPY
.. | . ....| |  |||||| |.|||.  . |  ..|.  
eallellellld.ggpvlvHCsaGkdRTGtvvallllllgvs
0051082 (Phosphotyrosine protein) phosphatases II 268-303 8.7e-06 20.9 In-house 83-118 (151) alignment 
Range on Protein: 268-303
Range on HMM: 83-118/151.0
FIAKAIADEGLSVLVHCSDGWDRTAQTCSLASIILD
|. .......  |||||| |..||.  . |  ..|.
flellldkkngpvlvHCsaGkgRTGtlvalylmllg
PTPc_DSPc_SM00012 271-374 1.5e-09 33.4 In-house 38-101 (105) alignment 
Range on Protein: 271-374
Range on HMM: 38-101/105.0
KaiadeGLSVLVHCSDGWDRTAQTCSLASIILDPYYRTiqgfqvliekewlafghkflhrcgllaydprevspVFTQFIECTWQLCQQFPCAFQFNERFL
.     . .|.||||.|..||.. . |. .. . ...|                                    . .. .. ..| .| | ..|..| .|
s.....skpvvVhCsaGvgRtgtfvaldillqqleket...................................kevdifqivkelrkqRpgmvqteeqyl

LELH
  ..
flyr
subfamily_pats1_pd Subfamily pats1 339-427 9.4e-26 82.3 In-house 550-638 (691) alignment 
Range on Protein: 339-427
Range on HMM: 550-638/691.0
REVSPVFTQFIECTWQLCQQFPCAFQFNERFLLELHDHVFSSQFGNFLGNCERERQDKKLSQKTFSLWQYMQARMSDYINPLYKANHPS
|  ||.| ||..  ||| ..||  |.||| .|| | ...|||.||||| .  ... ..|. ... |.| ...   | .|| |||    |
rsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykhsass
FYVE FYVE zinc finger 553-613 1.5e-13 40.4 Pfam-A 2-65 (69) alignment 
Range on Protein: 553-613
Range on HMM: 2-65/69.0
EWQSFRHIRQCS-CSSPFDYFSRKYHCWKCGEVFCIRCIDKQTQLP--GHESQRPVPVCRPCYR
.|.. .....|. |...| ...|. ||  ||.|.| .|..|... .   ......| ||. |..
kwvddaeakkCeiCakkFsltrrrhhCrlCGkvvCskCsskrvekleeesaeekevrvCkeCle