Gene Paladin in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Paladin
Subfamily Paladin
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP040_AA protein Get Run
SpurP040_AA_23-137 phosphatase_domain Get Run
SpurP040_AA_324-581 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Paladin_pd Subfamily Paladin 22-187 5.2e-57 183.2 In-house 154-314 (314) alignment 
Range on Protein: 22-187
Range on HMM: 154-314/314.0
LINADNEYAFYDDIEDLSDEPHLNQLTFIEDIQTTSEVYSLHSFGIHNASFTRVPMSSSKTPINEVIDQLLNAVKEVPSLFSNEESslPILVFTGHMGGG
.....|||..|.|.|.|..|......|..|...|..|||| ... ....|..|.|....|.|..|..||||...||||||.|.|..  |.|||..|.| |
ilkseneyevyadveelkeekeavlitrfetvltmeEvysqqlratptlsyhriplpeqkapleedldqllevlkevpsllskedg..palvFschsGkg

RTTFAMSLGILIMAHQRGfpaHVYDSHPSNDGSPKLELGEFWAIMKVCSLLPDGMKRKREVDSILD
|||.||....||..|..|   .| .    .  . ||  .||  .|||  ||||| . |.|||. ||
rTttamvvavLillhkkG...evgeeelvsvpdakltkeefqvvmkvvqllpdGrrvkkevdaald
0049772 (Phosphotyrosine protein) phosphatases II 24-137 9.8e-07 24.3 In-house 150-240 (314) alignment 
Range on Protein: 24-137
Range on HMM: 150-240/314.0
NADNEYafydDIEDLSDEPHLNqltfiediqttSEVYSLHSFGIHNASFTRVPMSSSKTPINEVIDQLLNAVKEVpslfsneESSLPILVfTGHMGGGRT
..|  .    .. . .| ..|.           .|.|. . |  ..  . |.|..   .|. | .|..|....|.       .   |.||   ..| |||
ildgng....neptaadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieea.......dkggpvlv.HCkaGkgRt

TFAMSLGILIMAHQ
. .. ...|.....
gtfvvaaylmkllg
PTPlike_phytase Inositol hexakisphosphate 52-133 8e-11 36.8 Pfam-A 80-148 (149) alignment 
Range on Protein: 52-133
Range on HMM: 80-148/149.0
DiqttsEVYSLHSFGIHNASFTRVPMSSSKTPINEVIDQLLNAVKEVPSlfsneessLPILVFTGHMGGGRTTFAMSLGILI
      |||. . .  .. .. |.|..  . | .| .|......|..|.         . |||  ..| ||||.|| .. |.
e.....evyeeelaegfgvkYvRipitdeqapeeedvDafvrlikslpr........dtalvfnCqaGrgRTTtamviadLl
PTPlike_phytase Inositol hexakisphosphate 52-133 8e-11 36.8 In-house 80-148 (149) alignment 
Range on Protein: 52-133
Range on HMM: 80-148/149.0
DiqttsEVYSLHSFGIHNASFTRVPMSSSKTPINEVIDQLLNAVKEVPSlfsneessLPILVFTGHMGGGRTTFAMSLGILI
      |||. . .  .. .. |.|..  . | .| .|......|..|.         . |||  ..| ||||.|| .. |.
e.....evyeeelaegfgvkYvRipitdeqapeeedvDafvrlikslpr........dtalvfnCqaGrgRTTtamviadLl
subfamily_Paladin_pd Subfamily Paladin 249-304 8.3e-20 61.0 In-house 46-101 (314) alignment 
Range on Protein: 249-304
Range on HMM: 46-101/314.0
VADDFVGLDVLRSQREVGTSNFRKVPGLPVYGMAQPSSKGQSAREYYLENALRYLK
|.||.|.||||...||||..|||||||||||||||||.||      ||..| | ..
veDdlvslDvLstvrevgvaNFRkvpglpvyGmaQPsakglervleyLtdakrrhr
subfamily_Paladin_pd Subfamily Paladin 324-633 4.2e-130 423.3 In-house 5-314 (314) alignment 
Range on Protein: 324-633
Range on HMM: 5-314/314.0
FCRSFTSWMRQHPELYTALAHINSSERTAPPELITKGLRFLVADDFVGLDVLRSQREVGTSNFRKVPGLPVYGMAQPSSKGLERVCQYLLSKKHGHSSIH
...||..|.|.|||||.. ....|.|..||..|...| .|||.||.|.||||...||||..|||||||||||||||||.||||||..|| ..|..|....
lalsfsrwlrahpelyrlpvtlssaedvaPedllvrgkyflveDdlvslDvLstvrevgvaNFRkvpglpvyGmaQPsakglervleyLtdakrrhrevv

SFNLRGEMIIQCDSTTYTPRELASLDKNISVSGLSERDVEKKEIQLKNEILRSKHSIQVYTDVAEPKKTIE------FDTVTTLHEMYEDQIKQTPQLHY
..||| |....||..||.|||...|..|....|....|.||.||||..|||.|.....||.||.|.|.. |      |.||.|..|.|..|...||.|.|
vvnlReeavlecDgvtYspRekknlkenlpgkgvavddleklEiqlrkeilkseneyevyadveelkeekeavlitrfetvltmeEvysqqlratptlsy

YHIVGGFQCSgPLEKTINRIVTVVKDLDDIFTDEDGPALLFNCHTGKEQTTVAMAIAGLIIWHKKGfpvgtKLGEQERISVPQAEYTKGEFSAVRKLVMR
..|. . |.. |||........|.|........||||||.|.||.||..||.||..| ||..||||     . ||.| .|||.|..||.||  | |.|  
hriplpeqka.pleedldqllevlkevpsllskedgpalvFschsGkgrTttamvvavLillhkkG.....evgeeelvsvpdakltkeefqvvmkvvql

LPHGTQVKREVDLMLD
||.| .||.|||  ||
lpdGrrvkkevdaald
0049772 (Phosphotyrosine protein) phosphatases II 325-581 5.9e-24 80.8 In-house 7-240 (314) alignment 
Range on Protein: 325-581
Range on HMM: 7-240/314.0
CrSFTSWMRqHPELYTALAHINSSERTAPPELItkglrFLVADDFVGLDVLRSQREVGTSNFRKVPGLPVYGMAQPSSKGLERVCQYLLSKKHghSSIHS
. ||  ... |..|. .|. .|. . ...|||.     .||||.|.. |..|......  |....|||||.|.........  ..... ....  ..|  
a.sfselli.hddllklllvlnrrslsvlpelt.....ilvadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgflkfIatqgp..leitv

FNLRGEMIIQCDSTTYTPRE------------------------------LASLDKNIsvSGLSERDVEKKEiqlkneilrskhsiqvytdvaepkktie
...| |......  ....|.                              | .|| |   . ....|.|  .                            
vdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk............................

fdtvttlHEMYEDQIKQTPQLHYYHIvggfQ---CSGPLEKTINRIVTVVKDLddiftdEDGPALLFNCHTGKEQTTVAMAIAGLIIWHK
        |.|...  . . ..|..|         | ||.. ..... .....      ..| ..|. |. ||  |......| |.. ..
.......eelydpelferlgikylri....pvpDgsaplledfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkllg
PTPlike_phytase Inositol hexakisphosphate 425-577 5.5e-23 76.2 Pfam-A 1-148 (149) alignment 
Range on Protein: 425-577
Range on HMM: 1-148/149.0
FNLRGEMIIQCDSTTYTPRELASLDKNI-SVSGLSERDVEKKEIQLKNEILRSKHSIQVYTDVAEPKKTIEfdtVTTL----HEMYEDQIKQTPQLHYYH
.||| | .....  ....||.. ...|. ..|| ... .|. | .||...|.   .... . |.. ... .   . ||    .|.|| .........|. 
inLReEpvvyingrpfvlreqedelenlkeysgieaeeledlekrlkedvlkeaeeyegrilvhreteegv...qktltevteevyeeelaegfgvkYvR

IVGGFQcSGPLEKTINRIVTVVKDLDDiftdedGPALLFNCHTGKEQTTVAMAIAGLI
|    . . | |... ..| ..|.| .       .||.|||..|.  ||.||.|| |.
ipitde.qapeeedvDafvrlikslpr......dtalvfnCqaGrgRTTtamviadLl
PTPlike_phytase Inositol hexakisphosphate 425-577 5.5e-23 76.2 In-house 1-148 (149) alignment 
Range on Protein: 425-577
Range on HMM: 1-148/149.0
FNLRGEMIIQCDSTTYTPRELASLDKNI-SVSGLSERDVEKKEIQLKNEILRSKHSIQVYTDVAEPKKTIEfdtVTTL----HEMYEDQIKQTPQLHYYH
.||| | .....  ....||.. ...|. ..|| ... .|. | .||...|.   .... . |.. ... .   . ||    .|.|| .........|. 
inLReEpvvyingrpfvlreqedelenlkeysgieaeeledlekrlkedvlkeaeeyegrilvhreteegv...qktltevteevyeeelaegfgvkYvR

IVGGFQcSGPLEKTINRIVTVVKDLDDiftdedGPALLFNCHTGKEQTTVAMAIAGLI
|    . . | |... ..| ..|.| .       .||.|||..|.  ||.||.|| |.
ipitde.qapeeedvDafvrlikslpr......dtalvfnCqaGrgRTTtamviadLl