Gene Auxilin-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP042_AA protein Get Run
SpurP042_AA_187-357 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Pkinase Protein kinase domain 7-139 7e-27 84.1 Pfam-A 70-185 (260) alignment 
Range on Protein: 7-139
Range on HMM: 70-185/260.0
QSEYLLLMELCPGGQLVDAINqRHMPLSCDDVLQTFYQACRGVQHMHKQtpPVTHRDIKLENFLIGSKKTLKLCDFGSATGKsyqpdsswsslkRSTLED
..|..|..|...||.| |... .. .|| ... . ..| ..|....|..   ..|||.| ||.|. .|..||..|||.|                .. |.
kdelylvleyveggdlfdllk.kkgklseeeikkialqilegleylHsn..giiHrDLKpeNiLldekgelkiaDFGlakkl............ekssek

EFARHTTPMYRPPEILDlyENFPINHAMDVWSA
   .  |. |..||.|   ..  . ...||||.
lttlvgtreYmAPEvll..kakeytkkvDvWsl
Pkinase_Tyr Protein tyrosine kinase 8-138 8.8e-17 51.0 Pfam-A 74-190 (259) alignment 
Range on Protein: 8-138
Range on HMM: 74-190/259.0
SEYLLLMELCPGGQLVDAINQR-HMPLSCDDVLQTFYQACRGVQHMHKQTppVTHRDIKLENFLIGSKKTLKLCDFGSATGKsyqpdsswssLKRSTLED
...|...|...||.| . .... . .|. .|.|.  .| ..|........  . |||.   | |. ..|. |..||| |              |... ..
epllivteyvegGdLlkfLrkkekekltledllsfalqiAkGmeyLeskk..lvHrdLaarNvLleenkvvkisDfGLardi..........ekddyykk

EFARHTTPMYRPPEILDLYEnfpINHAMDVWS
.  ...   . .||.|.  .   .... ||||
kekaklpvkWmapEslkekk...ftsksDvWs
PTEN_1 188-357 9.9e-35 115.1 In-house 7-193 (196) alignment 
Range on Protein: 188-357
Range on HMM: 7-193/196.0
RVAQTVASYTKSELDISYITSRIIVMS-FPAEG-----LESTYKNGIDDVRSFLETRHSGH-YHVFNLSQR------TYRPAK-FENRVS--DCGFPAKR
|. ..  ....  ||..|||||||.|. .|...      |..|.. ..||...|..... . ..|.||| .      .|.. . |...|.  .....   
rsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhg

PPNLVLLYHVCRNMYLWMQRDP-KNVCVIHCMDGKASSATIVSSFLTFCRLfSTVDVSLYMFSVKRGPPG-ITQSQKRYMEYISGMLS
.|.|  | ..|...  |...|| .||...||  |.  |.|.| ..| ...  .|.|  | ..  || | .  . ||.|..|| . .|.
apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapnspsqerlleyfaella
subfamily_VSP_pd Subfamily VSP 189-369 4.4e-37 122.1 In-house 20-211 (212) alignment 
Range on Protein: 189-369
Range on HMM: 20-211/212.0
VAQTVASYTKS--ELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNL-SQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNM
|..    ||.   .||..|.| ||| ||||. | .| |.| |..|  ||.|.|. ||.|.|| |.|.| .. |.|||. .    .  |.|  | ......
vsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkev

YLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGPPGI--------TQSQKRYMEYISGMLSPTASIMPHQRVL
  |...|.||| .|||  ||  . ||| ..|    .|.| . ||. |...|   .         | |||||..|.  .       .| ...|
kewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynrklppaktl
subfamily_Auxilin_pd Subfamily Auxilin 193-357 1.8e-87 284.3 In-house 1-165 (166) alignment 
Range on Protein: 193-357
Range on HMM: 1-165/166.0
VASYTKSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRD
||||.|..|||||||||||||||||||.|||||| |||||||||.||...|.|.||||||||.||...||...|.||.| |||  |..||||.| |...|
vasyakndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkd

PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGPPGITQSQKRYMEYISGMLS
||||.|.||.||.|.||..||..|.||||.|... ....||||| |.|...|.|||.||....|.
pknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpiglspsekryleyladlla
0046845 (Phosphotyrosine protein) phosphatases II 194-344 2.4e-09 32.5 In-house 62-259 (284) alignment 
Range on Protein: 194-344
Range on HMM: 62-259/284.0
ASYTKSE-LDISYITSRIIVMSFPAEG-----------------------------LESTYKNGIDDVRSF-------LETRHSGHYHVFNLSQRTYRPA
||| .   ||..||. ..|....| ..                               . | . ...|  .       |.. . ..| |..|. . . . 
AsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgyt

KFENRVSDCGF----PAKRPPNLVLLYHVCRNMYLWMQR-DPKNVCVIHCMDGKASSATIVSSFLTFCRLFS-----TVDVSLYMFSVKRGPPGITQS
... .|    .      . ||..  | . .| .  .... ..... |.||..|.  ..|..   | ...|       .|||  ..  ...  ||  |.
gesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
0043336 (Phosphotyrosine protein) phosphatases II 195-331 3.2e-12 42.0 In-house 65-251 (278) alignment 
Range on Protein: 195-331
Range on HMM: 65-251/278.0
SYTKSELDISYI----------TSRIIVMSFPAEGLESTYKNGIDDVR----------------------------------SFLETRHSGHYHVFNLSQ
| ....|| .||          . ..|....| .. .  . . . . .                                   .|.. | ..|.|..|  
sllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlev

R--TYRPAKFENRVSDCGFPAKRPP-NLVLLYHVCRNMYLWMQrDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLY----M
    . . .. ...   |.|    | .| || . .. .  ... |.... ..||..|.  ..|..  .| ...| ..  |.|.    .
tnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavke
subfamily_PTEN_pd Subfamily PTEN 197-356 2.9e-44 146.3 In-house 16-179 (184) alignment 
Range on Protein: 197-356
Range on HMM: 16-179/184.0
TKSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNL-SQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKN
 . .||.||||..||.|..|||.||..|.| ..||  |||..|..||...|| |.|.|  .||..||. ..|  . ||.| || ......  |...|.||
dgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkkn

VCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGP--PGITQ-SQKRYMEYISGML
| |.||. ||  . ......|  ..|... . .| .|. .|     |.|  ||.||.|| . .|
vvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekll
0039614 (Phosphotyrosine protein) phosphatases II 197-331 1e-14 50.2 In-house 79-263 (297) alignment 
Range on Protein: 197-331
Range on HMM: 79-263/297.0
TKSELDISYI-----------TSRIIVMSFPAEG-----LESTYKNGIDDVR----------------------------SFLETRHSGHYHVFNLSQRT
 .. || .||           | ..|....| ..     ..  ...|.  .                              .|.. | ..|.|..|. . 
dgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn

YRPAKFENRVSDCGFPAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSL----YM
. . .. ...   |.|   .| .| ||..... .  ..... .......||..|.  ..|..  .| ...| .. .|..     .
ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavke
0042113 (Phosphotyrosine protein) phosphatases II 197-346 2.1e-12 42.5 In-house 31-232 (245) alignment 
Range on Protein: 197-346
Range on HMM: 31-232/245.0
TKSELDISYI----------TSRIIVMSFPAEGLES-----TYKNGIDDVR------------------------------SFLETRHSGHYHVFNLSQR
....|| .||          | ..|....|...         ...||  .                                .|.. | ..|.|..|.  
dggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevt

--TYRPAKFENRVSDCGFPAKRPPN-LVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVS----LYMFSVKRGPPGITQS
   . . .. ...   ..|   .|. | ||  ... .  ....|.......||..|.  ..|..  .| ...| .. .||    ....  .|.    |.|
nlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtps

QK
| 
qy
0040438 (Phosphotyrosine protein) phosphatases II 197-331 1.1e-09 33.5 In-house 65-250 (317) alignment 
Range on Protein: 197-331
Range on HMM: 65-250/317.0
TKSELDISYI----------TSRIIVMSFPAEG-----LESTYKNGIDDVRSFLETR------------------------------HSGHYHVFNLSQR
... || .||          . ..|....| ..     ..  ...|.  . .. |.                               . .......|   
lggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtleve

T-YRPAKFENRVSDCGF-PAKRPP-NLVLLYHVCRNMYLWMQrDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSL----YM
  . . ......  . . |   .| .. || . .. .  ... ||......||..|.  ..|..  .| ...|  . .|..    ..
dlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavke
subfamily_Tensin_pd Subfamily Tensin 198-359 7.7e-44 142.4 In-house 8-174 (189) alignment 
Range on Protein: 198-359
Range on HMM: 8-174/189.0
KSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVC
| .||..|||.|||..||||||||..|.. . ||  .|...|. .| |||||.. |   |....| | |.| .  | |  |  .|...  |.. ||.|| 
kvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvv

VIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKR-----GPPGITQSQKRYMEYISGMLSPT
|.||  ||   . .||... . .. .. | .|  |..||       . .  ||.||.||.||.||  
vvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgk
0046846 (Phosphotyrosine protein) phosphatases II 198-351 9.9e-15 50.2 In-house 7-167 (176) alignment 
Range on Protein: 198-351
Range on HMM: 7-167/176.0
KSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETrhsGHYHVFNLSQRT-----------YRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMY
  .||..||. ..|..|.|. . ......  |... ..|    |...|.|| ...            .  |.. ..  ...|   .|.| ||..... ..
gldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefir

LWMQRDpkNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRG-PPGITQSQKRYMEY
 . ...  .. ..||. |.  ..|.|  .|  .. . .|.  |...  .|      |..| |. ..
ealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflye
0036282 (Phosphotyrosine protein) phosphatases II 200-356 6.4e-26 86.5 In-house 9-169 (174) alignment 
Range on Protein: 200-356
Range on HMM: 9-169/174.0
ELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQ-RTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCV
 ||.||||.|.|....|.. .|  ...|| .| ..|| .. |.| ..|.   . . . ..  .. ....|   .|.|  |..... .. ....||.....
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

IHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKR---GPPGITQSQKRYMEYISGML
.||. |.  ..|.|  .|  ..|.....  |...  .|   ..  .|.|| |.  |.. .|
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0043147 (Phosphotyrosine protein) phosphatases II 200-356 2e-14 49.2 In-house 12-160 (172) alignment 
Range on Protein: 200-356
Range on HMM: 12-160/172.0
ELDISYITSRIIVMSFPaeglestYKNGIDDVRSFLETRHSGHyhVFNLSQRTYRPAKFEN---RVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNV
 ||..||. |.|.. .|       . | ..|.. .| ... .|  ..|| ...| | ..|    ..  ...|   .|.| ||..... .. .....|...
yldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggp

CVIHCMDGKASSATIVSSFLTFCRLfsTVDVSLYMFSVKRGPPGITQSQKRYMEYISGML
...||. |.  ..|.|  .|  ..|  ...  . ..  ||.    ..|| |.  | . .|
vlVHCsaGvgRtgtlvaaylmllgl..sleeavalvrekRpgavqnpsqyrflyyfekll
0040439 (Phosphotyrosine protein) phosphatases II 200-330 9e-10 34.1 In-house 46-215 (249) alignment 
Range on Protein: 200-330
Range on HMM: 46-215/249.0
ELDISYITSRIIVMSFPAEGLESTYKNGIDDVR-----------------------------------SFLETRHSGHYHVFNLSQRT-YRPAKFENRVS
 .| .||. |.|....| ..  . . . . . .                                    .|.. ....|.|..|     | . ... .. 
yidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

DC-GFPAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLY
 . ..|    | ..  |   .. .  ..... .......||..|.  ..|..  .| ...|  . .|.|.
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdle
0045098 (Phosphotyrosine protein) phosphatases II 200-350 1.5e-09 33.1 In-house 6-265 (278) alignment 
Range on Protein: 200-350
Range on HMM: 6-265/278.0
ELDISYITSRIIVMSFPAEGLESTYKNGID----------------------------------------------------------------------
.||..... .......| | ... | ...|                                                                      
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

---------------------DVRSFlETRHSGHYHVFNLSQRTYRPAKFENRVSDC-GFPAKRPPNLV---LLYHVCRNMYLWMQ------------RD
                     ..  . .. .  ...| ||. . .   ... .. .. ..|   .|.|     . .... .  ...             |
caqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

PKNVCVIHCMDGKASSATIVSSFLTFCR---LFSTVDVSLYMFSVKRGPPGITQSQKRYME
.......||. |.  ..|.|  .|  ..    ..  ..  .. | ..|    ...| |...
sggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrfly
0041856 (Phosphotyrosine protein) phosphatases II 201-352 1.4e-15 52.8 In-house 17-166 (182) alignment 
Range on Protein: 201-352
Range on HMM: 17-166/182.0
LDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHY-HVFNLSQRTYRPAKFEN---RVSDCGFPAKRPPNLVLLYHVCRNMYLwmqrdPKNV
.|..||. .....|.||   . |. . ...| .||.. .. .. .. ||. . | | ..|.   .. . ..|   .|.|  |.. .. ..      ....
rdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eggp

CVIHCMDGKASSATIVSSFLTFCRlFSTVDVSLYMFSVKRGPPGITQSQKRYMEYI
...||. |.  ..|.|  .|  ..   ...  . ..  .|    || .| ..  ..
vlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpgmvitpnqyfflqla
0051082 (Phosphotyrosine protein) phosphatases II 201-348 5.6e-14 47.5 In-house 6-143 (151) alignment 
Range on Protein: 201-348
Range on HMM: 6-143/151.0
LDISYITSRIIVMSFPAEglestykngidDVRSFLetRHSGHYHVFNLSQRT---YRPAKFEN---RVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPK
...||.|........| .           |.  .|  .. |.....|| . .   | |  ...   .| .. ..   .|.| |... ....  .......
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVCVIHCMDGKASSATIVSSFLTFCRlfSTVDVSLYMFSVKRGpPGITQSQKRY
.....||. ||  ..|.|  .|  ..   ...  | ..  ||.   .. .| ..
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp.gvvqpnqqfl
0037934 (Phosphotyrosine protein) phosphatases II 201-350 2.2e-12 42.5 In-house 37-235 (243) alignment 
Range on Protein: 201-350
Range on HMM: 37-235/243.0
LDISYITSRIIVMSFPAEGLEST---------YKNGIDDVR----------------------------SFLETRHSGHYHVFNLSQRT---YRPAKFEN
.. .|.| |.|....| ..             ...||. .                              .|...| ..|.|..|. .    . . ..  
anliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvi

RVSDCGFPAKRPPN--------LVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGP-PGITQSQKRYME
..   ..|   .|.        |  .. ...........|.......||. |.  ..|..  .|   .|  ...  . ..  .|.     |.|| |.  
hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly
0044763 (Phosphotyrosine protein) phosphatases II 201-353 2.3e-10 35.9 In-house 21-167 (178) alignment 
Range on Protein: 201-353
Range on HMM: 21-167/178.0
LDISYITSRIIVMSFPAeglestykngiDDVRSFLetRHSGHYHVFNLSQ---------RTYRPAKFENRVSDCGFPAKRPPN-LVLLYHVCRNMYLWMQ
...|.|. .....|.|.            | . .|  .  |  |. ||..           | | ... ..  ...|   .|. |  .. ... .  ...
inaseilpglylgslpp...........addlell..kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald

RDPkNVCVIHCMDGKASSATIVSSFLTFCRLFsTVDVSLYMFSVKRGpPGITQSQKRYMEYIS
... .....||. |.  |.|.|  .|  .. . ...  . ..  .|    ....| |..... 
ekg.gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerRp.ivpnpgqlrqLyefe
0038934 (Phosphotyrosine protein) phosphatases II 204-350 4.4e-23 77.4 In-house 14-170 (194) alignment 
Range on Protein: 204-350
Range on HMM: 14-170/194.0
SYITSRIIVMSFPAEG-----LESTYKNGIDDVRSFLETRHSGHYHVFNLS--QRTYRPAKFEN---RVSDCGFPAK-RPPNLVLLYHVCRNMYLWMQRD
..|| |.|....|..|     .|..|.....|. ..|.... ....| .|.   |.| | .||.   .. .. || .  .|.| .|.. .. .. ....|
diitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned

PKNVCVIHCMDGKASSATIVSSFLTFCRLFsTVDVSLYMFSVKRGPPGITQSQKRYME
|..|...||. |.  ..|.| ..|  .. . ... ....|. ||..  ..|.. ... 
pggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekRpgaipnqdyleall
0045450 (Phosphotyrosine protein) phosphatases II 204-344 8.5e-12 40.9 In-house 108-291 (307) alignment 
Range on Protein: 204-344
Range on HMM: 108-291/307.0
SYI----------------------------------TSRIIVMSFPAEGLESTYKNgidDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGF--
 .|                                  ....... .| || | ||.|   ..  .|.. | ..|.|..|    ... ... .|    .  
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

-PAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRL--------FSTVDVSLYMFSVKrgpPGI--TQS
 |    | ..  | . .. .  ..... .......||..|.  ..|..  .|  ..|        ..  ..  .. . .   ||.  ...
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpe
0049772 (Phosphotyrosine protein) phosphatases II 205-351 2.7e-08 29.4 In-house 118-272 (314) alignment 
Range on Protein: 205-351
Range on HMM: 118-272/314.0
YITSRIIVM---------------------SFPAEGLEstyknGIDDVRSFLETRhsghyhvfnlsQRTYRPAKFENRVSDC---GFPAKRPPNLVLLYH
 . .|.|||                       .. |.      .. ... . . .           ...| | .||...       .|   .| |  ...
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk...........eelydpelferlgikylripvpDgsaplledfde

VCRNMYLWmqrDPKNVCVIHCMDGKASSAT-IVSSFLTFCRLFsTVDVSLYMFSVKRGpP----GITQSQKRYMEY
... .  .   |.... ..||..||  ..| .|  .|  .. . ...  | ..  ||       |  .....| ..
flefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefi
0049260 (Phosphotyrosine protein) phosphatases II 211-355 1.8e-11 39.5 In-house 5-148 (152) alignment 
Range on Protein: 211-355
Range on HMM: 5-148/152.0
IVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRT-YRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSA
. |.|.. . . .. | ..|.  .| . . ... . .  .   .   ..  ..  . .|   .|.|  |   .  .  ....|.......||. |.  ..
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

TIVSSFLTFcrLFSTVDVSLYMFSVKRGPPGITQSQKRYMEYISGM
|.|  .|    |  ...  . ..  ||    ....| |.  . ...
tlvaaylml..lgvsleeavalvrekRpgavpnpgqlrflyefekl
0048076 (Phosphotyrosine protein) phosphatases II 215-352 3.5e-11 38.5 In-house 3-138 (145) alignment 
Range on Protein: 215-352
Range on HMM: 3-138/145.0
FPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGFPAKRPPNL-VLLYHVCRNMYLWMQRDpkNVCVIHCMDGKASSATIVS
.|.| |.. | ... ..... . .. |...|.||.  .. . ..  ..  ...|   .|.|  ||..... .  .....  .....||. |.  ..|.| 
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlva

SFLTFCRLFSTVDVsLYMFSVKRGPPGITQSQKRYMEYI
 .| ... .|  .. | ..  .|    ....| |.... 
aylmlllgvsleea.lelvrsqrpgavpnpgqlrflyef
0048179 (Phosphotyrosine protein) phosphatases II 215-352 4.8e-11 38.1 In-house 3-140 (144) alignment 
Range on Protein: 215-352
Range on HMM: 3-140/144.0
FPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFEN--RVSDCGFPAKRPPNL-VLLYHVCRNMYLWMQRDpkNVCVIHCMDGKASSATI
.|.| |.. | ... ..... . .. |...|.||.   . .    .  ..  ...|   .|.|  ||..... .  .....  .....||. |.  ..|.
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

VSSFLTFCRLFStVDVSLYMFSVKRGPPGITQSQKRYMEYI
|  .| ... .| ..  |...  .|    ....| |.... 
vaaylmkklgls.leealalvrsrrpgavpnpgqlrfLley
0051299 (Phosphotyrosine protein) phosphatases II 234-344 2.1e-06 22.9 In-house 153-271 (288) alignment 
Range on Protein: 234-344
Range on HMM: 153-271/288.0
FLETRHSGHYHVFNLSQRTYR---PAKFENRVSDCGF----PAKRPPNLVLLYHVCRNMYLWMQrDPKNVCVIHCMDGKASSATIVSSFLTFCRL--FST
.|.. . ..| |..|  . ..   . ... .|    .        |... || . .| .. ... ......|.||..|.  ..|..  .| ...|    .
llseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekegg

VDVSLYMFSVKRGPPGITQS
|||  ..  ...  ||. |.
vdvleavkrlreqRpgmvqt
0047943 (Phosphotyrosine protein) phosphatases II 234-330 2.8e-06 22.5 In-house 141-241 (273) alignment 
Range on Protein: 234-330
Range on HMM: 141-241/273.0
FLETRHSGHYHVFNLSQRT--YRPAKFENRVSDCGFPAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSL
.|.. . ..| |..|  .   .   .. . .   |.|    | .|  | . .. .  ... .  ... |.||..|.  ..|..  .| ...|  .  |..
llseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdv

Y
.
l
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 365-499 1.1e-23 74.8 Pfam-A 2-127 (134) alignment 
Range on Protein: 365-499
Range on HMM: 2-127/134.0
HQRVLLIKSLRLTPVPLYnKMRSGCRPFCEVFHDEERILSTSQEYERMRGFEVEDASAFIDLNIPVCGDVMVVVYHARSTfggkvqgK----VtglkMFQ
... | .||..| ..| . |.|.||.|...|.  .. . .....|. ..  . ...   .. ..||.|||.| ..| .|.       .         .|.
npkrlelksiilegiPnf.ktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsk.......lpkkek....ifr

FQFNTGFIEPGTKEISFNRYELDFFELDKfAEHFHASLD
..||| |||  .. . ....||| .  ||  ..|.    
vwFNTsFieknqnvltlpkneLDkalkdk.dkkfsknfk
DnaJ DnaJ domain 1153-1197 6e-08 21.6 Pfam-A 13-55 (64) alignment 
Range on Protein: 1153-1197
Range on HMM: 13-55/64.0
EHNQVKKWYRKAVLSAHPDKQVGTPneELAKLIFMELSDAWSAFE
  ...|| ||| .|  ||||  . .  | |.  | |...|... .
sdeeIkkaYrklalkyHPDknkdde..eeaeekfkeineAyevLs