Gene Auxilin-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP043_AA protein Get Run
SpurP043_AA_269-439 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Pkinase_Tyr Protein tyrosine kinase 33-200 3.5e-11 32.6 Pfam-A 105-259 (259) alignment 
Range on Protein: 33-200
Range on HMM: 105-259/259.0
KLKVRRVIAEGFAfvYVAQENSTGKEFALKleNFLIGSKKTLKLCDFGSATSKsyqpdsswssLKRSTLEDEFARHTTPMYRPPEILDLYEnfpINHAMD
.|..   ||.| .  | ....   .. | .  | |. ..|. |..||| | .            |... ...  ...   . .||.|.  .   .... |
llsfalqiAkGme..yLeskklvHrdLaar..NvLleenkvvkisDfGLardi..........ekddyykkkekaklpvkWmapEslkekk...ftsksD

VWALGCMLYTMCY-RQHPFEDSAKLR---IINANYTIPEDDEEYMILHDLIRAMLQVDPRNRPPLEVIVAQL
||. | .|. ..   ..|...  . .    ..... ... ..    |..|..  .. .|..|| .. .| .|
vWsfGvllwEiftlgespypglsneevleklkegkrlekpencpeelyelmkqCweeepekRptfkelvekl
Pkinase Protein kinase domain 61-197 4.7e-22 68.3 Pfam-A 124-255 (260) alignment 
Range on Protein: 61-197
Range on HMM: 124-255/260.0
LKLENFLIGSKKTLKLCDFGSATSKsyqpdsswsslkRSTLEDEFARHTTPMYRPPEILDlyENFPINHAMDVWALGCMLYTMCYRQHPFEDS---AKLR
|| ||.|. .|..||..|||.|                .. |.   .  |. |..||.|   ..  . ...|||.||..||... .. ||...    .|.
LKpeNiLldekgelkiaDFGlakkl............eksseklttlvgtreYmAPEvll..kakeytkkvDvWslGvilyelltgklpfsgeseedqle

IINANYTIPEDDE------EYMILHDLIRAMLQVDPRNRPPLEVIV
.|... . . . .      .   | |||. .|. ||..|. .| |.
lirkilkkkleedepkssskseelkdlikkllekdpakRltaeeil
Kinase-like Kinase-like 110-190 1.5e-06 16.5 Pfam-A 206-289 (289) alignment 
Range on Protein: 110-190
Range on HMM: 206-289/289.0
TPMYRPPEILDLY-----ENFPINHAMDVWALGCMLYTMCYRQHPFEDSAKLRIINANYTIPEDDEEYmiLHDLIRAMLQVDPRNR
   . |||.|        ... ..|..|.|.||  .| .  .. ||. .|.  ... ..   .   |   .. |.. .|| . ..|
ekalaPpellaekggytsnttkmthkldaWqlGlviysiwclrlPftllaeeaseewkfklckkvpek..vklLvkklLqrsqeaR
PTEN_1 270-439 1.1e-34 115.0 In-house 7-193 (196) alignment 
Range on Protein: 270-439
Range on HMM: 7-193/196.0
RVAQTVASYTKSELDISYITSRIIVMS-FPAEG-----LESTYKNGIDDVRSFLETRHSGH-YHVFNLSQR------TYRPAK-FENRVS--DCGFPAKR
|. ..  ....  ||..|||||||.|. .|...      |..|.. ..||...|..... . ..|.||| .      .|.. . |...|.  .....   
rsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhg

PPNLVLLYHVCRNMYLWMQRDP-KNVCVIHCMDGKASSATIVSSFLTFCRLfSTVDVSLYMFSVKRGPPG-ITQSQKRYMEYISGMLS
.|.|  | ..|...  |...|| .||...||  |.  |.|.| ..| ...  .|.|  | ..  || | .  . ||.|..|| . .|.
apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapnspsqerlleyfaella
subfamily_VSP_pd Subfamily VSP 271-451 4.8e-37 121.9 In-house 20-211 (212) alignment 
Range on Protein: 271-451
Range on HMM: 20-211/212.0
VAQTVASYTKS--ELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNL-SQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNM
|..    ||.   .||..|.| ||| ||||. | .| |.| |..|  ||.|.|. ||.|.|| |.|.| .. |.|||. .    .  |.|  | ......
vsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkev

YLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGPPGI--------TQSQKRYMEYISGMLSPTASIMPHQRVL
  |...|.||| .|||  ||  . ||| ..|    .|.| . ||. |...|   .         | |||||..|.  .       .| ...|
kewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynrklppaktl
subfamily_Auxilin_pd Subfamily Auxilin 275-439 1.9e-87 284.1 In-house 1-165 (166) alignment 
Range on Protein: 275-439
Range on HMM: 1-165/166.0
VASYTKSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRD
||||.|..|||||||||||||||||||.|||||| |||||||||.||...|.|.||||||||.||...||...|.||.| |||  |..||||.| |...|
vasyakndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkd

PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGPPGITQSQKRYMEYISGMLS
||||.|.||.||.|.||..||..|.||||.|... ....||||| |.|...|.|||.||....|.
pknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpiglspsekryleyladlla
0046845 (Phosphotyrosine protein) phosphatases II 276-426 2.6e-09 32.3 In-house 62-259 (284) alignment 
Range on Protein: 276-426
Range on HMM: 62-259/284.0
ASYTKSE-LDISYITSRIIVMSFPAEG-----------------------------LESTYKNGIDDVRSF-------LETRHSGHYHVFNLSQRTYRPA
||| .   ||..||. ..|....| ..                               . | . ...|  .       |.. . ..| |..|. . . . 
AsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgyt

KFENRVSDCGF----PAKRPPNLVLLYHVCRNMYLWMQR-DPKNVCVIHCMDGKASSATIVSSFLTFCRLFS-----TVDVSLYMFSVKRGPPGITQS
... .|    .      . ||..  | . .| .  .... ..... |.||..|.  ..|..   | ...|       .|||  ..  ...  ||  |.
gesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt
0043336 (Phosphotyrosine protein) phosphatases II 277-413 5.2e-12 41.3 In-house 65-251 (278) alignment 
Range on Protein: 277-413
Range on HMM: 65-251/278.0
SYTKSELDISYI----------TSRIIVMSFPAEGLESTYKNGIDDVR----------------------------------SFLETRHSGHYHVFNLSQ
| ....|| .||          . ..|....| .. .  . . . . .                                   .|.. | ..|.|..|  
sllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlev

R--TYRPAKFENRVSDCGFPAKRPP-NLVLLYHVCRNMYLWMQrDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLY----M
    . . .. ...   |.|    | .| || . .. .  ... |.... ..||..|.  ..|..  .| ...| ..  |.|.    .
tnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavke
subfamily_PTEN_pd Subfamily PTEN 279-438 3.2e-44 146.1 In-house 16-179 (184) alignment 
Range on Protein: 279-438
Range on HMM: 16-179/184.0
TKSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNL-SQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKN
 . .||.||||..||.|..|||.||..|.| ..||  |||..|..||...|| |.|.|  .||..||. ..|  . ||.| || ......  |...|.||
dgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkkn

VCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGP--PGITQ-SQKRYMEYISGML
| |.||. ||  . ......|  ..|... . .| .|. .|     |.|  ||.||.|| . .|
vvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekll
0039614 (Phosphotyrosine protein) phosphatases II 279-413 2e-14 49.2 In-house 79-263 (297) alignment 
Range on Protein: 279-413
Range on HMM: 79-263/297.0
TKSELDISYI-----------TSRIIVMSFPAEG-----LESTYKNGIDDVR----------------------------SFLETRHSGHYHVFNLSQRT
 .. || .||           | ..|....| ..     ..  ...|.  .                              .|.. | ..|.|..|. . 
dgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn

YRPAKFENRVSDCGFPAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSL----YM
. . .. ...   |.|   .| .| ||..... .  ..... .......||..|.  ..|..  .| ...| .. .|..     .
ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavke
0042113 (Phosphotyrosine protein) phosphatases II 279-428 2.3e-12 42.3 In-house 31-232 (245) alignment 
Range on Protein: 279-428
Range on HMM: 31-232/245.0
TKSELDISYI----------TSRIIVMSFPAEGLES-----TYKNGIDDVR------------------------------SFLETRHSGHYHVFNLSQR
....|| .||          | ..|....|...         ...||  .                                .|.. | ..|.|..|.  
dggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevt

--TYRPAKFENRVSDCGFPAKRPPN-LVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVS----LYMFSVKRGPPGITQS
   . . .. ...   ..|   .|. | ||  ... .  ....|.......||..|.  ..|..  .| ...| .. .||    ....  .|.    |.|
nlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtps

QK
| 
qy
subfamily_Tensin_pd Subfamily Tensin 280-441 8.5e-44 142.3 In-house 8-174 (189) alignment 
Range on Protein: 280-441
Range on HMM: 8-174/189.0
KSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVC
| .||..|||.|||..||||||||..|.. . ||  .|...|. .| |||||.. |   |....| | |.| .  | |  |  .|...  |.. ||.|| 
kvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvv

VIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKR-----GPPGITQSQKRYMEYISGMLSPT
|.||  ||   . .||... . .. .. | .|  |..||       . .  ||.||.||.||.||  
vvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgk
0046846 (Phosphotyrosine protein) phosphatases II 280-433 1.1e-14 50.1 In-house 7-167 (176) alignment 
Range on Protein: 280-433
Range on HMM: 7-167/176.0
KSELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETrhsGHYHVFNLSQRT-----------YRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMY
  .||..||. ..|..|.|. . ......  |... ..|    |...|.|| ...            .  |.. ..  ...|   .|.| ||..... ..
gldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefir

LWMQRDpkNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRG-PPGITQSQKRYMEY
 . ...  .. ..||. |.  ..|.|  .|  .. . .|.  |...  .|      |..| |. ..
ealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflye
0040438 (Phosphotyrosine protein) phosphatases II 280-414 2.2e-09 32.5 In-house 66-251 (317) alignment 
Range on Protein: 280-414
Range on HMM: 66-251/317.0
KSELDISYI----------TSRIIVMSFPAEG-----LESTYKNGIDDVRSFLETR------------------------------HSGHYHVFNLSQRT
.. || .||          . ..|....| ..     ..  ...|.  . .. |.                               . .......|    
ggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtleved

-YRPAKFENRVSDCGF-PAKRPP-NLVLLYHVCRNMYLWMQrDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSL----YMF
 . . ......  . . |   .| .. || . .. .  ... ||......||..|.  ..|..  .| ...|  . .|..    ...
lgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel
0036282 (Phosphotyrosine protein) phosphatases II 282-438 7.1e-26 86.4 In-house 9-169 (174) alignment 
Range on Protein: 282-438
Range on HMM: 9-169/174.0
ELDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQ-RTYRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCV
 ||.||||.|.|....|.. .|  ...|| .| ..|| .. |.| ..|.   . . . ..  .. ....|   .|.|  |..... .. ....||.....
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

IHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKR---GPPGITQSQKRYMEYISGML
.||. |.  ..|.|  .|  ..|.....  |...  .|   ..  .|.|| |.  |.. .|
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0043147 (Phosphotyrosine protein) phosphatases II 282-438 2.2e-14 49.0 In-house 12-160 (172) alignment 
Range on Protein: 282-438
Range on HMM: 12-160/172.0
ELDISYITSRIIVMSFPaeglestYKNGIDDVRSFLETRHSGHyhVFNLSQRTYRPAKFEN---RVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNV
 ||..||. |.|.. .|       . | ..|.. .| ... .|  ..|| ...| | ..|    ..  ...|   .|.| ||..... .. .....|...
yldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggp

CVIHCMDGKASSATIVSSFLTFCRLfsTVDVSLYMFSVKRGPPGITQSQKRYMEYISGML
...||. |.  ..|.|  .|  ..|  ...  . ..  ||.    ..|| |.  | . .|
vlVHCsaGvgRtgtlvaaylmllgl..sleeavalvrekRpgavqnpsqyrflyyfekll
0040439 (Phosphotyrosine protein) phosphatases II 282-412 9.9e-10 33.9 In-house 46-215 (249) alignment 
Range on Protein: 282-412
Range on HMM: 46-215/249.0
ELDISYITSRIIVMSFPAEGLESTYKNGIDDVR-----------------------------------SFLETRHSGHYHVFNLSQRT-YRPAKFENRVS
 .| .||. |.|....| ..  . . . . . .                                    .|.. ....|.|..|     | . ... .. 
yidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

DC-GFPAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLY
 . ..|    | ..  |   .. .  ..... .......||..|.  ..|..  .| ...|  . .|.|.
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdle
0045098 (Phosphotyrosine protein) phosphatases II 282-432 1.7e-09 33.0 In-house 6-265 (278) alignment 
Range on Protein: 282-432
Range on HMM: 6-265/278.0
ELDISYITSRIIVMSFPAEGLESTYKNGID----------------------------------------------------------------------
.||..... .......| | ... | ...|                                                                      
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

---------------------DVRSFlETRHSGHYHVFNLSQRTYRPAKFENRVSDC-GFPAKRPPNLV---LLYHVCRNMYLWMQ------------RD
                     ..  . .. .  ...| ||. . .   ... .. .. ..|   .|.|     . .... .  ...             |
caqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

PKNVCVIHCMDGKASSATIVSSFLTFCR---LFSTVDVSLYMFSVKRGPPGITQSQKRYME
.......||. |.  ..|.|  .|  ..    ..  ..  .. | ..|    ...| |...
sggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrfly
0041856 (Phosphotyrosine protein) phosphatases II 283-434 1.6e-15 52.6 In-house 17-166 (182) alignment 
Range on Protein: 283-434
Range on HMM: 17-166/182.0
LDISYITSRIIVMSFPAEGLESTYKNGIDDVRSFLETRHSGHY-HVFNLSQRTYRPAKFEN---RVSDCGFPAKRPPNLVLLYHVCRNMYLwmqrdPKNV
.|..||. .....|.||   . |. . ...| .||.. .. .. .. ||. . | | ..|.   .. . ..|   .|.|  |.. .. ..      ....
rdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eggp

CVIHCMDGKASSATIVSSFLTFCRlFSTVDVSLYMFSVKRGPPGITQSQKRYMEYI
...||. |.  ..|.|  .|  ..   ...  . ..  .|    || .| ..  ..
vlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpgmvitpnqyfflqla
0051082 (Phosphotyrosine protein) phosphatases II 283-430 6.1e-14 47.4 In-house 6-143 (151) alignment 
Range on Protein: 283-430
Range on HMM: 6-143/151.0
LDISYITSRIIVMSFPAEglestykngidDVRSFLetRHSGHYHVFNLSQRT---YRPAKFEN---RVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPK
...||.|........| .           |.  .|  .. |.....|| . .   | |  ...   .| .. ..   .|.| |... ....  .......
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVCVIHCMDGKASSATIVSSFLTFCRlfSTVDVSLYMFSVKRGpPGITQSQKRY
.....||. ||  ..|.|  .|  ..   ...  | ..  ||.   .. .| ..
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp.gvvqpnqqfl
0037934 (Phosphotyrosine protein) phosphatases II 283-432 2.6e-12 42.3 In-house 37-235 (243) alignment 
Range on Protein: 283-432
Range on HMM: 37-235/243.0
LDISYITSRIIVMSFPAEGLEST---------YKNGIDDVR----------------------------SFLETRHSGHYHVFNLSQRT---YRPAKFEN
.. .|.| |.|....| ..             ...||. .                              .|...| ..|.|..|. .    . . ..  
anliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvi

RVSDCGFPAKRPPN--------LVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSLYMFSVKRGP-PGITQSQKRYME
..   ..|   .|.        |  .. ...........|.......||. |.  ..|..  .|   .|  ...  . ..  .|.     |.|| |.  
hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly
0044763 (Phosphotyrosine protein) phosphatases II 283-435 2.5e-10 35.8 In-house 21-167 (178) alignment 
Range on Protein: 283-435
Range on HMM: 21-167/178.0
LDISYITSRIIVMSFPAeglestykngiDDVRSFLetRHSGHYHVFNLSQ---------RTYRPAKFENRVSDCGFPAKRPPN-LVLLYHVCRNMYLWMQ
...|.|. .....|.|.            | . .|  .  |  |. ||..           | | ... ..  ...|   .|. |  .. ... .  ...
inaseilpglylgslpp...........addlell..kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald

RDPkNVCVIHCMDGKASSATIVSSFLTFCRLFsTVDVSLYMFSVKRGpPGITQSQKRYMEYIS
... .....||. |.  |.|.|  .|  .. . ...  . ..  .|    ....| |..... 
ekg.gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerRp.ivpnpgqlrqLyefe
0038934 (Phosphotyrosine protein) phosphatases II 286-432 4.9e-23 77.2 In-house 14-170 (194) alignment 
Range on Protein: 286-432
Range on HMM: 14-170/194.0
SYITSRIIVMSFPAEG-----LESTYKNGIDDVRSFLETRHSGHYHVFNLS--QRTYRPAKFEN---RVSDCGFPAK-RPPNLVLLYHVCRNMYLWMQRD
..|| |.|....|..|     .|..|.....|. ..|.... ....| .|.   |.| | .||.   .. .. || .  .|.| .|.. .. .. ....|
diitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned

PKNVCVIHCMDGKASSATIVSSFLTFCRLFsTVDVSLYMFSVKRGPPGITQSQKRYME
|..|...||. |.  ..|.| ..|  .. . ... ....|. ||..  ..|.. ... 
pggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekRpgaipnqdyleall
0045450 (Phosphotyrosine protein) phosphatases II 287-426 1.3e-11 40.2 In-house 143-291 (307) alignment 
Range on Protein: 287-426
Range on HMM: 143-291/307.0
YITSRIIVMSFPAEGLESTYKNgidDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGF---PAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVI
. ....... .| || | ||.|   ..  .|.. | ..|.|..|    ... ... .|    .   |    | ..  | . .. .  ..... .......
elgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlV

HCMDGKASSATIVSSFLTFCRL--------FSTVDVSLYMFSVKrgpPGI--TQS
||..|.  ..|..  .|  ..|        ..  ..  .. . .   ||.  ...
HCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpe
0049772 (Phosphotyrosine protein) phosphatases II 287-433 3.1e-08 29.2 In-house 118-272 (314) alignment 
Range on Protein: 287-433
Range on HMM: 118-272/314.0
YITSRIIVM---------------------SFPAEGLEstyknGIDDVRSFLETRhsghyhvfnlsQRTYRPAKFENRVSDC---GFPAKRPPNLVLLYH
 . .|.|||                       .. |.      .. ... . . .           ...| | .||...       .|   .| |  ...
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk...........eelydpelferlgikylripvpDgsaplledfde

VCRNMYLWmqrDPKNVCVIHCMDGKASSAT-IVSSFLTFCRLFsTVDVSLYMFSVKRGpP----GITQSQKRYMEY
... .  .   |.... ..||..||  ..| .|  .|  .. . ...  | ..  ||       |  .....| ..
flefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefi
0049260 (Phosphotyrosine protein) phosphatases II 293-437 1.9e-11 39.3 In-house 5-148 (152) alignment 
Range on Protein: 293-437
Range on HMM: 5-148/152.0
IVMSFPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRT-YRPAKFENRVSDCGFPAKRPPNLVLLYHVCRNMYLWMQRDPKNVCVIHCMDGKASSA
. |.|.. . . .. | ..|.  .| . . ... . .  .   .   ..  ..  . .|   .|.|  |   .  .  ....|.......||. |.  ..
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

TIVSSFLTFcrLFSTVDVSLYMFSVKRGPPGITQSQKRYMEYISGM
|.|  .|    |  ...  . ..  ||    ....| |.  . ...
tlvaaylml..lgvsleeavalvrekRpgavpnpgqlrflyefekl
0048076 (Phosphotyrosine protein) phosphatases II 297-434 3.9e-11 38.3 In-house 3-138 (145) alignment 
Range on Protein: 297-434
Range on HMM: 3-138/145.0
FPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFENRVSDCGFPAKRPPNL-VLLYHVCRNMYLWMQRDpkNVCVIHCMDGKASSATIVS
.|.| |.. | ... ..... . .. |...|.||.  .. . ..  ..  ...|   .|.|  ||..... .  .....  .....||. |.  ..|.| 
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlva

SFLTFCRLFSTVDVsLYMFSVKRGPPGITQSQKRYMEYI
 .| ... .|  .. | ..  .|    ....| |.... 
aylmlllgvsleea.lelvrsqrpgavpnpgqlrflyef
0048179 (Phosphotyrosine protein) phosphatases II 297-434 5.2e-11 38.0 In-house 3-140 (144) alignment 
Range on Protein: 297-434
Range on HMM: 3-140/144.0
FPAEGLESTYKNGIDDVRSFLETRHSGHYHVFNLSQRTYRPAKFEN--RVSDCGFPAKRPPNL-VLLYHVCRNMYLWMQRDpkNVCVIHCMDGKASSATI
.|.| |.. | ... ..... . .. |...|.||.   . .    .  ..  ...|   .|.|  ||..... .  .....  .....||. |.  ..|.
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

VSSFLTFCRLFStVDVSLYMFSVKRGPPGITQSQKRYMEYI
|  .| ... .| ..  |...  .|    ....| |.... 
vaaylmkklgls.leealalvrsrrpgavpnpgqlrfLley
0051299 (Phosphotyrosine protein) phosphatases II 316-426 2.3e-06 22.7 In-house 153-271 (288) alignment 
Range on Protein: 316-426
Range on HMM: 153-271/288.0
FLETRHSGHYHVFNLSQRTYR---PAKFENRVSDCGF----PAKRPPNLVLLYHVCRNMYLWMQrDPKNVCVIHCMDGKASSATIVSSFLTFCRL--FST
.|.. . ..| |..|  . ..   . ... .|    .        |... || . .| .. ... ......|.||..|.  ..|..  .| ...|    .
llseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekegg

VDVSLYMFSVKRGPPGITQS
|||  ..  ...  ||. |.
vdvleavkrlreqRpgmvqt
0047943 (Phosphotyrosine protein) phosphatases II 316-412 3.1e-06 22.3 In-house 141-241 (273) alignment 
Range on Protein: 316-412
Range on HMM: 141-241/273.0
FLETRHSGHYHVFNLSQRT--YRPAKFENRVSDCGFPAKRPP-NLVLLYHVCRNMYLWMQRD-PKNVCVIHCMDGKASSATIVSSFLTFCRLFSTVDVSL
.|.. . ..| |..|  .   .   .. . .   |.|    | .|  | . .. .  ... .  ... |.||..|.  ..|..  .| ...|  .  |..
llseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdv

Y
.
l
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 447-584 1.5e-18 58.3 Pfam-A 2-127 (134) alignment 
Range on Protein: 447-584
Range on HMM: 2-127/134.0
HQRVLLIKSLRLTPVPLYnKMRSGCpsvRPYVRTSVPDELIRFGGHEVKGQRGFEVEDASAFIDLNIPVCGDVMVVVYHARSTfggkvqgK----Vtglk
... | .||..| ..| . |.|.||   .|.|. .  .. .    .. | ..  . ...   .. ..||.|||.| ..| .|.       .         
npkrlelksiilegiPnf.ktrggc...kpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsk.......lpkkek....

MFQFQFNTGFIEPGTKEISFNRYELDFFELDKfAEHFHASLD
.|...||| |||  .. . ....||| .  ||  ..|.    
ifrvwFNTsFieknqnvltlpkneLDkalkdk.dkkfsknfk
DnaJ DnaJ domain 1237-1280 7.1e-08 21.4 Pfam-A 13-54 (64) alignment 
Range on Protein: 1237-1280
Range on HMM: 13-54/64.0
EHNQVKKWYRKAVLSAHPDKQVGTPneELAKLIFMELSDAWSAF
  ...|| ||| .|  ||||  . .  | |.  | |...|... 
sdeeIkkaYrklalkyHPDknkdde..eeaeekfkeineAyevL