Gene PTEN-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP045_AA protein Get Run
SpurP045_AA_2-176 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 1-178 4.6e-86 282.5 In-house 5-182 (184) alignment 
Range on Protein: 1-178
Range on HMM: 5-182/184.0
MVSKKKRRFIDKGFDLDLSYIYPNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFYNRVAHYPFDDHNPPRLELIKPFCED
.|||||.|| ..|.|||||||..||||||.|||.||..|||.|| ||||...|| ..||.|||.|||.||..|| .|||.|||||||||.|||.....||
ivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeived

LDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKNRKGVTIPSQRRYVEYYGNLIVRE
...|| .| .||...|||||||||||.|.||.|...|...|.|||...|..||||.||||||||||||||| .|. .|
iekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee
subfamily_VSP_pd Subfamily VSP 1-177 8.4e-63 206.1 In-house 19-200 (212) alignment 
Range on Protein: 1-177
Range on HMM: 19-200/212.0
MVSKKKRRFIDKGFDLDLSYIYPNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFYNRVAHYPFDDHNPPRLELIKPFCED
.||. |||.   ||||||.|.   |||| ||.   . .||| .. |..|...|| ..|||.||||||.|| . | ||| .   |||| |.|| .  |...
lvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftke

LDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKNR-----KGVTIPSQRRYVEYYGNLIVR
. .|| .| .|| ||||| |||||| ..||..|.  ...|| |.||.....||..      .||  |||.|||.|. ... .
vkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktk
0039614 (Phosphotyrosine protein) phosphatases II 3-171 4.9e-35 116.8 In-house 56-284 (297) alignment 
Range on Protein: 3-171
Range on HMM: 56-284/297.0
SKKKRRFI--------------DKGFDLDLSYI-----------YPNIIAMGFPAES-----LEGVYRNKLEVVV-------------------------
.|.|.|..               .|.|||..||            ...||...| ..     .. |.... .|.|                         
nkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygd

---KFFNEKHGERYKVYNLCSERnYDTTKFYNRVAHYPFDDHNPP-RLELIKPFCEDLDNWLGAD-GQNVAAIHCKAGKGRTGVMICAYMLH----RRLY
   .. ...| . |.|..|. .. .. ....... .... ||..|  |||.  |.| ....| .. .... ..||.||.||||..|.||...    ..  
ftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekegg

QTASEALDFYASKRtknRKGVTIPSQRRYVEYY
 .. ||.... ..|   ...|..||| |.. ..
vdvleavkelreqR...pgavqtpsqyrflyda
0037934 (Phosphotyrosine protein) phosphatases II 3-171 1e-34 115.6 In-house 10-237 (243) alignment 
Range on Protein: 3-171
Range on HMM: 10-237/243.0
SKKKRRFI--------------DKGFDLDLSYIYPNIIAMGFPAES---------LEGVYRNKLEVVV----------------------------KFFN
...|.|.               .  ....|.|..|..||...| ..         .. ..... .|.|                            .. .
nlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtlls

EKHGERYKVYNLCSER--NYDTTKFYNRVAHYPFDDHNPPR-LELIKPFCEDLDNWLGA-------DGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTA
|.|.. |.|..|. |.   .| |..  .. ..|. ||..|   | .  |.... ... .       |.... ..||.||.||||..|.||.....|  ..
eehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdl

SEALDFYASKRTKnrKGVTIPSQRRYVEYY
 ||.... ..|    |.|..|||.|.. ..
eeavkllreqRpg..kavqtpsqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 3-171 7.7e-32 106.0 In-house 9-238 (245) alignment 
Range on Protein: 3-171
Range on HMM: 9-238/245.0
SKKKRRF-------------IDKGFDLDLSYI----------YPNIIAMGFPAESLEG-----VYRNKLEVVV---------------------------
.|.|.|.              . |.|||..||          .|..||...|...  .     .........|                           
nkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygd

---KFFNEKHGERYKVYNLCSER-NYDTTKFYNRVAHYPFDDHNPPR-LELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLH----RRLY
   .. .|.| . |.|..|. ..  .| ... ... ..|..||..|  |||.  |.| ....| .|.... ..||.||.||||..|.||...    ..| 
ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelg

QTASEALDFYASKRtknRKGVTIPSQRRYVEYY
 .. ||.... |.|   .. |..||| |.. ..
vsleeavkelrsqR...pgavqtpsqyrflyea
0045450 (Phosphotyrosine protein) phosphatases II 3-171 1.3e-28 96.1 In-house 55-299 (307) alignment 
Range on Protein: 3-171
Range on HMM: 55-299/307.0
SKKKRRFID-------------------------------------KGFDLDLSYI----------------------------------YPNIIAMGFP
.|.|.|. |                                     .|.||.. .|                                    ...|. .|
nkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywP

AESLEGVYRNkleVVVKFFNEKHGERYKVYNLCSERNyDTTKFYNRVAHYPF---DDHNPP-RLELIKPFCEDLDNWLGAD-GQNVAAIHCKAGKGRTGV
 |. | .|.|   ..|.. .|.| . |.|..|. ... | |..  .| |...    ||. |  .| .  |.| ....|... .... ..||.||.||||.
degeeltygn...ftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGt

MICAYMLHRRLY-------QTASEALDFYASKRtknRKGVTIPSQRRYVEYY
.|.||.. |.|         .. ||.... ..|    ..|. |.| |.. ..
fiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 3-171 5.4e-27 90.4 In-house 11-241 (249) alignment 
Range on Protein: 3-171
Range on HMM: 11-241/249.0
SKKKRRFI---------------DKGFD--------LDLSYIYPNIIAMGFPAESLEGVYRNKLE-----------------------------------
.|.|.|.                ...|.        .|..|| ...||...| ..  . ... |                                    
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygd

VVVKFFNEKHGERYKVYNLCSERNYDTTKFYNRVAHY-PFDDHNPP-RLELIKPFCEDLDNWLGAD-GQNVAAIHCKAGKGRTGVMICAYMLH----RRL
..|....... . |.|..|. ...|| .... .. .| .. ||. |  .| .  |.| ....| ..  ... ..||.||.||||..|.||...    ..|
ftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekel

YQTASEALDFYASKRtknRKGVTIPSQRRYVEYY
  .. ||.... |.|   ...|. |.| |.. ..
gvdleeavkllrsqR...pgavqnpeqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 4-173 1.5e-31 105.3 In-house 44-273 (317) alignment 
Range on Protein: 4-173
Range on HMM: 44-273/317.0
KKKRRF-------------IDKGFDLDLSYI----------YPNIIAMGFPAES-----LEGVYRNKLEVVVKFFNEK----------------------
|.|.|.              . |.|||..||           ...||...| ..     .. |......|.| . ...                      
kdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdf

--------HGERYKVYNLCSERNYDTTKFYNRVAHYPF-DDHNPP-RLELIKPFCEDLDNWLGaDGQNVAAIHCKAGKGRTGVMICAYMLH----RRLYQ
        . . .....|. | ..| ....... ||.. .||..|  ..|.  |.| ....|  |.... ..||.||.||||..|.||...    ..   
tvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

TASEALDFYASKRtknRKGVTIPSQRRYVEYYGN
.. ||.... ..|   ...|. |.| |.. .. .
dveeavkelreqR...pgavqtpeqyrflydall
PTEN_1 5-174 2.8e-47 156.1 In-house 9-191 (196) alignment 
Range on Protein: 5-174
Range on HMM: 9-191/196.0
KKRRFIDKGFDLDLSYIYPNIIAMG-FPAES-----LEGVYRNKLEVVVKFFNEKHGER-YKVYNLCSERN-----YDTTK-FYNRVA--HYPFDDHNPP
.|.. .. ...|||.||.. ||||| .|...      ||.||. |. |..........  . |.||..|..     || .. | ..|   |.|..||..|
skknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgap

RLELIKPFCEDLDNWLGADG-QNVAAIHCKAGKGRTGVMICAYMLHRRLyQTASEALDFYASKRTKNRKGvtIPSQRRYVEYYGNL
 |. .  .|.....|| .|  .||...|||||.||.|....||.....   || |||.....||.....   .|||.|..||. .|
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfael
0046845 (Phosphotyrosine protein) phosphatases II 5-170 2.1e-23 78.5 In-house 30-268 (284) alignment 
Range on Protein: 5-170
Range on HMM: 30-268/284.0
KKRRFID-----------------------------KGFDLDLSYIYPNIIAMGFPAES-----------------------------LEGVYRNKLE--
.| |. |                             .|.||||.|| ...||. .| ..                                 |..  .  
sknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegev

-----VVVKFFNEKHGERYKVYNLCSERNyDTTKFYNRVAHYPF---DDHNPP-RLELIKPFCEDLDNWLGA-DGQNVAAIHCKAGKGRTGVMICAYMLH
     . |.. .|.. . |.|..|. ... ..|... .| |. .    ||. |  .| .  |.......| . .|... ..||.||.||||..|....|.
ltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdlll

RRLYQTA----SEALDFYASKRTKNRKGVTIPSQRRYVEY
..| ..       .|. ..  |..    |. ..| |.| .
eqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvye
0041856 (Phosphotyrosine protein) phosphatases II 6-171 2.2e-31 104.3 In-house 4-166 (182) alignment 
Range on Protein: 6-171
Range on HMM: 4-166/182.0
KRRFID---KGFDLDLSYIYPNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYK-VYNLCsERNYDTTKFYN---RVAHYPFDDHNPPRLELIKPFC
|.|. |     ...||.|| .|......||   .  ... |. | .|..  ...... . ||. |..|. .....   .. ..|..||..| |. .  |.
knrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfi

EDLDNwlgadGQNVAAIHCKAGKGRTGVMICAYMLHRRlYQTASEALDFYASKRtknRKGVTIPSQRRYVEYY
|.  .      ... ..||.||.||||....||.....   .. ||.... |.|    ..|..|.| ... ..
eevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrR...pgmvitpnqyfflqla
0043336 (Phosphotyrosine protein) phosphatases II 6-171 2.5e-29 98.1 In-house 48-272 (278) alignment 
Range on Protein: 6-171
Range on HMM: 48-272/278.0
KRRF-------------IDKGFDLDLSYI----------YPNIIAMGFPAESLEGVYRNKLEV----------------------------------VVK
|.|.              . |.|||..||           ...||...| .. .. ... .                                    .|.
knrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvt

FFNEKHGERYKVYNLCSER-NYDTTKFYNRVAHYPFDDHNPP-RLELIKPFCEDLDNWLGaDGQNVAAIHCKAGKGRTGVMICAYMLH----RRLYQTAS
. .|.| . |.|..|. ..  .. ... ... .... ||. |  |.|.  |.......|  | ... ..||.||.||||..|..|.|.    ...  .. 
llkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdle

EALDFYASKRtknRKGVTIPSQRRYVEYY
||.... ..|    . |. ||| |.. ..
eavkelreqR...pgavqtpsqyrflyea
subfamily_Tensin_pd Subfamily Tensin 7-187 1.6e-48 157.8 In-house 2-183 (189) alignment 
Range on Protein: 7-187
Range on HMM: 2-183/189.0
RRFIDKGFDLDLSYIYPNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLcSERNYDTTKFYNRVAHYPFDDHNPPRLELIKPFCEDLDNWLG
 |.... .||||.||   |||. ||||.||  ||..|. |.|....||...| |.|| ||..|| .|. ..|  . . |.  | || .   |..||.|| 
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

ADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKNRK--GVTIPSQRRYVEYYGNLIVRELEYKPTTLL
|| |||...||| ||||.||.. ||| . .. ..|..||| .| ||  ..|  |.| |||||||||. .|.. ... .   |.
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplf
0044763 (Phosphotyrosine protein) phosphatases II 8-175 2.8e-26 87.7 In-house 13-170 (178) alignment 
Range on Protein: 8-175
Range on HMM: 13-170/178.0
RFIDKGFDLDLSYIYPNIIAMGFPAES-LEGVYRNKLEVVVKFFNEKHGERYKvynlcsERNYDTTKFYNRVAHYPFDDHNPPR-LELIKPFCEDLDNWL
. .  .. ...|.|.|.......|... || ...... ..| . .|... ..|      .  |. ...  .. |.|..||..|  || .  |.| ....|
eglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflk......cdpywpeeagiqylhipipDhgvpdllehflefvefieeal

GADGqNVAAIHCKAGKGRTGVMICAYMLHRRlYQTASEALDFYASKRtknRkGVTIPSQRRYVEYYGNLI
  .| .. ..||.||.||.|....||.....   .. ||.... ..|   . .|. |.|.|.....   .
dekg.gpvlVHCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR...p.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 9-173 1.7e-35 117.7 In-house 3-170 (176) alignment 
Range on Protein: 9-173
Range on HMM: 3-170/176.0
FIDKGFDLDLSYIYPNIIAMGFP-----------AESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSErnydTTKFYNRVAHYPFDDHNPPRLELIKPF
.   |.||||.||..|.|....|           |. || ..... ..|| . .|.. .|.|..|...|     .|.  .. |.|..||..| |||.  .
lrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgiqylhlpwpDhgvpdlelllel

CEDLDNWLGADgqNVAAIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKnrKGVTIPSQRRYVEYYGN
.| ....| ..  .. ..||.||.||||....||.|...   .. |||... ..| .  . |. |.|.|.....  
lefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 13-176 1.1e-31 105.2 In-house 10-161 (172) alignment 
Range on Protein: 13-176
Range on HMM: 10-161/172.0
GFDLDLSYIYPNIIAMGFPaeslegvYRNKLEVVVKFFNEKHGERykVYNLCsER---NYDTTKFYNRVAHYPFDDHNPPRLELIKPFCEDLDNWLGADG
 ..|||.|| ...||. .|       .|| |. ..... |..     ..||. |.    .. .... .. ..|..||..| |||.  |.| .|..|  . 
asyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidellalsp

QNVAAIHCKAGKGRTGVMICAYMLHrrLYQTASEALDFYASKRtknRKGVTIPSQRRYVEYYGNLIV
... ..||.||.||||....||...  |  .. ||.... .||   ...|..|||.|.. |. .|..
ggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR...pgavqnpsqyrflyyfeklll
0045098 (Phosphotyrosine protein) phosphatases II 13-174 3.8e-25 84.3 In-house 4-270 (278) alignment 
Range on Protein: 13-174
Range on HMM: 4-270/278.0
GFDLDLSYIYPNIIAMGFPAESLEGVYRNKLE-------------------------------------------------------VVVKFFNEKHGE-
...|||.... .....|.| | ....|.. |.                                                       |.|   ...... 
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

----------------------------------RYKVYNLCSERNYDTtKFYNRVAHY-PFDDHNPPRLE---LIKPFCEDLDNWLG------------
                                  ...|.||..||.... ... .. || |..||..| |.    .  ..| ....|             
ekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

ADGQNVAAIHCKAGKGRTGVMICAYMLHRRLyQTASEALDFYASKRTKNRK-GVTIPSQRRYVEYYGNL
 |.... ..||.||.||||....||.. ..| .    .|. ..  |.. .   |....| |.....  .
ldsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyeflle
0036282 (Phosphotyrosine protein) phosphatases II 14-173 4.1e-45 148.9 In-house 8-167 (174) alignment 
Range on Protein: 14-173
Range on HMM: 8-167/174.0
FDLDLSYIYPNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFYNRVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVA
..|||||| |..||...|.. .| ........|| . .||. ..||..|...|. .| ...  .. ..|..||..| |. .  |.. ....|  |.... 
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

AIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKNRKGVTIPSQRRYVEYYGN
..||.||.||||....||...|.|.... .|||.....|... ..|..|||.|.. |.. 
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
subfamily_Auxilin_pd Subfamily Auxilin 15-175 4.4e-43 139.9 In-house 8-164 (166) alignment 
Range on Protein: 15-175
Range on HMM: 8-164/166.0
DLDLSYIYPNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLcSERNYDTTKFYNRVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAA
|||.|||   || | |||| .|  |.|... | .| . .| |.|.|||| |.|.|.|.|. .|| .. .  .. | || .   | .|..|| .| .||  
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKNRkgvTIPSQRRYVEYYGNLI
.||| |.  ..|...|.... ||......|..... ||.        ||..||.|| ..|.
vhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladll
0049772 (Phosphotyrosine protein) phosphatases II 15-174 3.7e-28 94.6 In-house 118-276 (314) alignment 
Range on Protein: 15-174
Range on HMM: 118-276/314.0
DLDLSYIYP---------------------NIIAMGFPaeslegvyrnklevvvkffNEKHGERYKVYNlcsERNYDTTKFYNRVAHY---PFDDHNPPR
||.. .|..                     ..|..|..                   || . .... ..   |. ||  .| ... .|   |..|...| 
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng...................neptaadlellk...eelydpelferlgikylripvpDgsapl

LELIKPFCEDLDNWlgaDGQNVAAIHCKAGKGRTGV-MICAYMLHRRLYqTASEALDFYASKRTKNRKGVTIPSQRRYVEYYGNL
|| .. |.| ....   | ... ..||||||||||. ...||..... . .. |||... .||. | . ..|.....|....  |
ledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefileal
subfamily_CDC14_pd Subfamily CDC14 15-169 3.3e-13 44.2 In-house 169-317 (328) alignment 
Range on Protein: 15-169
Range on HMM: 169-317/328.0
DLDLSYIYPN-IIAMGFPAES--LEGVY-RNKLEVVVKFFNEKHGEryKVYNLCsERNYDTTKFYNR-VAHY--PFDDHNPPRLELIKPFCEDLDNWlga
  |...| |. ..|.  | .   ||  |  .. | ....|.... .  .|  |  ...|| .|| .  ..|.   | |   |  ...| | | ...    
nGDfnwivPdkflalagPhnkskledgyplhaPeklleyfrknnvt..tvvrLn.kklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka...

dgQNVAAIHCKAGKGRTGVMICAYMLHRrLYQTASEALDFYaskRTkNRKGVTIPSQRRYVE
  .  .|.||||| |||| .| .|....    ||.||. .    |   | |. |  |....|
..eGaiavhCkaGLGrtGtLiacylmkh.yrftaaeaiawl...ri.crPGsvigpqqkfle
0051082 (Phosphotyrosine protein) phosphatases II 16-171 1.9e-26 87.9 In-house 6-147 (151) alignment 
Range on Protein: 16-171
Range on HMM: 6-147/151.0
LDLSYIYPNIIAMGFPAEslegvyrnkleVVVKFFneKHGERYKVYNLCS--ERNYDTTKFYN---RVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQ
...||. ......|.| .            .....  |.   . ..||.|  ||.|..  . .   .| |.|..|. .| |.|. ... .. ..| ....
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVAAIHCKAGKGRTGVMICAYMLHRRlyQTASEALDFYASKRTknrkGVTIPSQRRYVEYY
.. ..||.|||||||.....|.....   .. |||..| .||.    ||..|.| ......
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlf
0038934 (Phosphotyrosine protein) phosphatases II 20-172 3.3e-38 126.7 In-house 15-167 (194) alignment 
Range on Protein: 20-172
Range on HMM: 15-167/194.0
YIYPNIIAMGFPAES-----LEGVYRNKLEVVVKFFNEKHGERYKVYNLC-SERNYDTTKFYN---RVAHYPFDDH-NPPRLELIKPFCEDLDNWLGADG
.| ...||...|...     .|..||. .| .|....... . ..|..|. .|| ||...|..   .. ..|| |. ..| ||... |.. .| .| .| 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

QNVAAIHCKAGKGRTGVMICAYMLHRRLYqTASEALDFYASKRtknrkgvtiPSQRRYVEYYG
..| |.|||||.||||....||...|. . .| ||......||         |.. ....|. 
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgaipnqdyle
0051429 (Phosphotyrosine protein) phosphatases II 23-171 2.5e-11 39.3 In-house 68-220 (272) alignment 
Range on Protein: 23-171
Range on HMM: 68-220/272.0
PNIIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNY--DTTKFYNRVAHYPFDDHNPPRlELIKPFCEDLDNwlgadgQNVAAIHCKAG
|.|  . .| .. .    . . ..|... |.. . | ...|. .. .  ...  .    .. . ||. |. | .. . | | .      ..   .||.||
pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld......ggpvlvHCsaG

KGRTGVMICAYMLHRRLYQ---------TASEALDFYASKRTKNRKGVTIPSQRRYVEYY
|.|||.......| ...           |   ......  | . .. |  . |....  .
kdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
0049260 (Phosphotyrosine protein) phosphatases II 25-173 3.1e-32 106.7 In-house 4-147 (152) alignment 
Range on Protein: 25-173
Range on HMM: 4-147/152.0
IIAMGFPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFYNRVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRT
..||.|..   .|...| |. ..... | .   . ... ..|.... ...| .. |.|..||..| |. . .|. .....|  | ... ..||.||.|||
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRt

GVMICAYMLHrrlyqTASEALDFYASKRTKNRKGVTIPSQRRYVEYYGN
|....||...        ......|  |.|. ..|. |.|.|.. .. .
gtlvaaylml.....lgvsleeavalvrekRpgavpnpgqlrflyefek
0048179 (Phosphotyrosine protein) phosphatases II 30-173 1.7e-25 84.9 In-house 3-142 (144) alignment 
Range on Protein: 30-173
Range on HMM: 3-142/144.0
FPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFYN-RVAHYPFDDHNPPRL-ELIKPFCEDLDNWLGADgqNVAAIHCKAGKGRTGVM
.|.| |.|.|.. | ..... . |.   . |.||..|. ..  .... .. |.|..||..| | ||.  |.| ....|  .  .. ..||.||.||||..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

ICAYMLHrRLYQTASEALDFYASKRTknrKGVTIPSQRRYVEYYGN
..||... .|  .. |||... |.|     .|. |.|.|....|..
vaaylmk.klglsleealalvrsrrp...gavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 30-172 1.8e-25 84.7 In-house 3-139 (145) alignment 
Range on Protein: 30-172
Range on HMM: 3-139/145.0
FPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTtKFYNRVAHYPFDDHNPPRL-ELIKPFCEDLDNWLGADgqNVAAIHCKAGKGRTGVMI
.|.| |.|.|.. | ..... . |.   . |.||.||... . ..  .. ..|..||..| | ||.  |.| ....| ..  .. ..||.||.||||...
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CAYMLHRrLYQTASEALDFYASKRtknRKGVTIPSQRRYVEYYG
.||.... |  .. |||... |.|   ...|. |.|.|..... 
aaylmll.lgvsleealelvrsqr...pgavpnpgqlrflyefe
0036941 (Phosphotyrosine protein) phosphatases II 30-172 2e-17 58.9 In-house 124-273 (297) alignment 
Range on Protein: 30-172
Range on HMM: 124-273/297.0
FPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFYNRVAHYP-FDDHNPPR-LELIKPFCEDLDNWLGAD-GQNVAAIHCKAGKGRTGV
.| |  | .. ... | .. ..... . |....|. . . .  ... .. ||.  .||..|   . .  |.| ....| .  ....  .||.||.||.|.
wpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgt

MICAYMLHRRL----YQTASEALDFYASKRTKNRKGVTIPSQRRYVEYYG
.|.|......|    ..     |... . |..    |. ..| |.. .. 
fiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 30-141 2.3e-07 25.2 In-house 119-232 (274) alignment 
Range on Protein: 30-141
Range on HMM: 119-232/274.0
FPAESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKfynrVAHYPF----DDHNPPRLELIKPFCEDLDNWLGADGQNVA--AIHCKAGKGR
|| .    .  .  .| .|. . .. . |.| .|  .   .. .    | || .    | . | . . .  .... ..   .. ...|   .|| || ||
fPdaedyeiserygdveikvekiverndysvrklvlkylerers....vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGr

TGVMICAYMLHRRLYQTA
||. | . .  |.| .. 
tGcfiaisiavrqlreei
Y_phosphatase Protein-tyrosine phosphatase 40-159 4.3e-07 25.0 Pfam-A 98-220 (235) alignment 
Range on Protein: 40-159
Range on HMM: 98-220/235.0
RNKLEVVVKfFNEK-HGERYKVYNLCSERNYDT--TKFYNRVAHYPFDDHNPP-RLELIKPFCEDLDNWLgADGQNVAAIHCKAGKGRTGVMICAYMLHR
 ....| .|  .|| . ..| ...|  . . .   ..  . . .    ||. |   . .  ..... ..  .. ..   .||.|| ||||..... .| .
ygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

RLYQT-ASEALDFYASKRTKNRKGV
.| ..   . |..  . |.. .. |
qleaeeevdvlqivkelRkqRpgmv
Y_phosphatase Protein-tyrosine phosphatase 40-159 4.3e-07 25.0 In-house 98-220 (235) alignment 
Range on Protein: 40-159
Range on HMM: 98-220/235.0
RNKLEVVVKfFNEK-HGERYKVYNLCSERNYDT--TKFYNRVAHYPFDDHNPP-RLELIKPFCEDLDNWLgADGQNVAAIHCKAGKGRTGVMICAYMLHR
 ....| .|  .|| . ..| ...|  . . .   ..  . . .    ||. |   . .  ..... ..  .. ..   .||.|| ||||..... .| .
ygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldille

RLYQT-ASEALDFYASKRTKNRKGV
.| ..   . |..  . |.. .. |
qleaeeevdvlqivkelRkqRpgmv
DSPc_SM00195 43-142 7.8e-06 20.8 In-house 126-227 (263) alignment 
Range on Protein: 43-142
Range on HMM: 126-227/263.0
LEVVVKFFNEKHGE-RYKVYNLCSERNYD-TTKFYNRVAHYPFDDHNPP-RLELIKPFCEDLDNWLGADgQNVAAIHCKAGKGRTGVMICAYMLHRRLYQ
 .. ||. .... .  .....|  . . . .|.. . . .    ||. |   . .  . . ....     ..   .||.|| ||||..... .. ..| .
gkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilsklee

TAS
.  
ekk
PTPc_SM00194 43-142 7.8e-06 20.8 In-house 126-227 (263) alignment 
Range on Protein: 43-142
Range on HMM: 126-227/263.0
LEVVVKFFNEKHGE-RYKVYNLCSERNYD-TTKFYNRVAHYPFDDHNPP-RLELIKPFCEDLDNWLGADgQNVAAIHCKAGKGRTGVMICAYMLHRRLYQ
 .. ||. .... .  .....|  . . . .|.. . . .    ||. |   . .  . . ....     ..   .||.|| ||||..... .. ..| .
gkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilsklee

TAS
.  
ekk
0047943 (Phosphotyrosine protein) phosphatases II 44-169 8.5e-22 73.3 In-house 136-265 (273) alignment 
Range on Protein: 44-169
Range on HMM: 136-265/273.0
EVVVKFFNEKHGERYKVYNLCSER-NYDTTKFYNRVAHYPFDDHNPP-RLELIKPFCEDLDNWLGAD-GQNVAAIHCKAGKGRTGVMICAYMLHRRL-YQ
.. |.. .|.. . |.|..|. .. ... ..... . .... ||. |  || .  |.|.....| |. .... ..||.||.||||..|....|...| . 
kftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke

TASEALDFYASKRTKNRKGVTIPSQRRYVE
    .|. ..  |..   .|. |.|.|.. 
ggvdvleavkllrsqRpgmvqtpeqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 45-169 3.8e-22 74.5 In-house 149-279 (288) alignment 
Range on Protein: 45-169
Range on HMM: 149-279/288.0
VVVKFFNEKHGERYKVYNLCSERN--YDTTKFYNRVAHYPF----DDHNPPRLELIKPFCEDLDNWLGaDGQNVAAIHCKAGKGRTGVMICAYMLHRRL-
..|.. .|.. . |.|..|. ...  .| .... .| |. .    |.. |. .||.  |.......|  .|... ..||.||.||||..|....|...| 
itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqle

YQTASEALDFYASKRTKNRKGVTIPSQRRYVE
..   ..|....  |..    |. |.| |.| 
keggvdvleavkrlreqRpgmvqtpeqyrfvy
0050432 (Phosphotyrosine protein) phosphatases II 45-168 1.2e-16 56.4 In-house 168-291 (308) alignment 
Range on Protein: 45-168
Range on HMM: 168-291/308.0
VVVKFFNEKHGERYKVYNLCSERNYDTTKFYNRVAHYPF--DDHNPPRLELIKPFCEDLDNWLgadGQNVAAIHCKAGKGRTGVMICAYMLHRRL-YQTA
..|.. .|.. . |.|..|. . . |   .. .. ||.   |.. || .| .  |.| ....|   .... ..||.|| ||||..|....|...| ..  
ftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekegg

SEALDFYASKRTKNRKGVTIPSQRRYV
  ... ..  |..    |. |.| ...
vdvfeavkklReqRpgmvqtpeqylfl
subfamily_PRL_pd Subfamily PRL 51-154 2.2e-10 34.8 In-house 28-132 (151) alignment 
Range on Protein: 51-154
Range on HMM: 28-132/151.0
NEKHGERYKVYNLCSERNYDTTKFYN---RVAHYPFDDHNPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLyqTASEALDF
.| . |  |    . | .|||.|. .   .|  ..||| ..|  |... . | | .    ..... |.|| || ||. |...  ..   .  .  .|..|
eelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm..kyedavef

YASKRTK
  .||  
irekrrg
0048567 (Phosphotyrosine protein) phosphatases II 66-153 6.1e-11 36.9 In-house 25-119 (157) alignment 
Range on Protein: 66-153
Range on HMM: 25-119/157.0
ERNYDTTKF-YNR--VAHYPFDDHNPPRLELIKPFCEDLDNWLG--ADGQNVAAIHCKAGK---GRTGVMICAYMLHRrLYQTASEALDFYASKRT
...|..  | ...  | . .| |. |. | ..  |.  |...|.      .. |.|||||    |||...|..|.. . |  |..||.....  | 
kslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilh.lgftpeeaiaplrivrp
subfamily_DSP11_pd Subfamily DSP11 66-152 2.4e-10 34.6 In-house 67-157 (178) alignment 
Range on Protein: 66-152
Range on HMM: 67-157/178.0
ERNYDTTKFYNR-VAHYP--FDDHNPPRLELIKPFCEDLDNWL--GADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTaSEALDFYASKR
.| |..... .. | ..      |. |. ||.| |.| ....|   .| ... ..||  |  ||| .|| |....  |.. ..|.. . . |
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyep.edaieafeear
subfamily_RNGTT_pd Subfamily RNGTT 67-154 9.7e-10 32.4 In-house 66-156 (189) alignment 
Range on Protein: 67-154
Range on HMM: 66-156/189.0
RNYDTTKFYNR-VA--HYPFDDH-NPPRLELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQtASEALDFYASKRTK
| ||. .. .. .   .     . . |  | .| | . ....     ..| ..||. |  ||| .|..|..... .. ...|.. .|. | .
ryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedws.veaavalFakaRpp
PTPc_DSPc_SM00012 83-167 1.8e-11 39.5 In-house 10-96 (105) alignment 
Range on Protein: 83-167
Range on HMM: 10-96/105.0
FDDHNPP-RLELIKPFCEDLDNWLGADG-QNVAAIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASKRTKNRKGVTIPSQRRY
  ||. | . . |  ........  . . ..   .||.|| ||||.......|...|... .|   |   |. ....  .. ... |
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy
subfamily_DSP23_pd Subfamily DSP23 83-145 4.6e-08 27.9 In-house 59-118 (148) alignment 
Range on Protein: 83-145
Range on HMM: 59-118/148.0
FDDHNPPRLELIKPFCEDLDNwlgADG-QNVAAIHCKAGKGRTGVMICAYMLHRRLYqTASEAL
 ||. || || .. | . ...   |.  ..  ..||  |.|||| |.  |... |   .|.||.
iddyhppaleqvvefvrvvee...aeekneavsvhcllgrgrtgtmlacylvkerkl.aaaeai
DSPc Dual specificity phosphatase, catalytic domain 106-157 7.4e-09 30.6 Pfam-A 70-119 (133) alignment 
Range on Protein: 106-157
Range on HMM: 70-119/133.0
GADGQNVaAIHCKAGKGRTGVMICAYMLHRRLYqTASEALDFYASKRTKNRK
 ..|..| ..||.||  |.. .|.||.. .. . ...||..|  ..| | ..
eqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskisp
DSPc Dual specificity phosphatase, catalytic domain 106-157 7.4e-09 30.6 In-house 70-119 (133) alignment 
Range on Protein: 106-157
Range on HMM: 70-119/133.0
GADGQNVaAIHCKAGKGRTGVMICAYMLHRRLYqTASEALDFYASKRTKNRK
 ..|..| ..||.||  |.. .|.||.. .. . ...||..|  ..| | ..
eqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskisp
PTPc_motif_SM00404 107-156 6.3e-08 27.6 In-house 78-125 (140) alignment 
Range on Protein: 107-156
Range on HMM: 78-125/140.0
ADGQNVaAIHCKAGKGRTGVMICAYMLHRRLYQtASEALDFYASKRTKNR
..|..|  .||.||  |.. .|.||....| .. ..||..|. ..| . .
kkggkv.lVHCqaGvSRSatliiaYlmryrqls.laeayefvkerRpiis
subfamily_PTPMT1_pd Subfamily PTPMT1 109-156 8.6e-08 26.8 In-house 107-152 (171) alignment 
Range on Protein: 109-156
Range on HMM: 107-152/171.0
GQNVaAIHCKAGKGRTGVMICAYMLHRRLYqTASEALDFYASKRTKNR
|. |  .|||||.||.. .. .|.....   .  |||.. ..|| . |
gkrv.YvHCkaGrgRsatlvacylmkkekl.speeAlkalkkkRkiir
subfamily_PTPDC1_pd Subfamily PTPDC1 112-155 6.6e-11 37.0 In-house 116-158 (182) alignment 
Range on Protein: 112-155
Range on HMM: 116-158/182.0
VAAIHCKAGKGRTGVMICAYMLHRRLYqTASEALDFYASKRTKN
  |.|| ||.|||||.|..|... . . ||..|...  |||.| 
kvavhChaGlGrtGvliacylvyakrl.taekaiklvrskrpks
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 181-343 2.8e-37 118.9 Pfam-A 1-133 (134) alignment 
Range on Protein: 181-343
Range on HMM: 1-133/134.0
YKPTTLLLTRIDLETVPMF-NGGSCAPAFVIYQQKVKIFS-SQPYEVAKKE--RSVRCEFPLPVPICGDIKIEFFNKP-NKLKKDRMFHFWFNTFFVANs
|.|..| |..| ||..|.| ..|.| | . .|..|.|.|. .. |.  ...  ... ...| ..|..||...||..|  .. ||...|..||||.|. . 
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiek.

nllnsssqqdlanngssdnsshcsednmealdaDCTVLRLQKDQLDRANKDKtNKWYSPNFKVICYFK
                                 . .|| |.|..||.|.||| .| .|.||||  .|.
.................................nqnvltlpkneLDkalkdk.dkkfsknfkvelvfe