Gene VSP in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily VSP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP047_AA protein Get Run
SpurP047_AA_8-229 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_VSP_pd Subfamily VSP 4-211 1.6e-121 398.0 In-house 4-211 (212) alignment 
Range on Protein: 4-211
Range on HMM: 4-211/212.0
RLISERRHVTKASRKLVSENKRRYLQDGFDLDLTYVTDRIIASSFPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINLCSERHYDESYFNHQVIRVQTDD
||....|...||.|.||||||||| ||||||||||||.||||.|||||||||.||||||||.|||.|||.|||||.||||||.|||.|||..|.|...||
rlltqkrklekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkrilidd

HNVPKLEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQTAKECLDFFGSRRTDLDEGDKFQGVQTPSQSRYVHYFEQVKFKYGG
||||||||||.|.|..|||.|.|.|||..||||||||||||.||..||.||.|.||||.||.||.|||| .||.||||||||||.|||.|.||||.||. 
hnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynr

QIPEPKDL
..|..|.|
klppaktl
0040438 (Phosphotyrosine protein) phosphatases II 9-229 9.8e-30 99.3 In-house 31-306 (317) alignment 
Range on Protein: 9-229
Range on HMM: 31-306/317.0
RRHVTKASRKLVSENKRRY-------------LQDGFDLDLTYV----------TDRIIASSFPSSG-----KQSIYRNPISEVSRFLNTK---------
  . .. ...... .|.||               .|.|||..|.          ....|| ..| ..      . .... .. . .. ...         
kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaq

---------------------HPDHYKVINLCSERHYDESYFNHQVIRVQT-DDHNVP-KLEELLKFSKIAKEWMEaDPKNVMFIHCKGGKGRTGTAVCT
                     . ..... .|. | ..|.  .  ...   . .||.||  ...||.| ....|..| ||.... .||..|.||||| .. 
YwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaa

WLL----ESEAFQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQVKFKYGGQIPEPKDLIIENIRIRNLAGLGKGDG
.|.    | | . ...|..... ..|         ..||||.| |.......  .|.... .. ..|. . ... .   |.. ..
ylmleqlekeggvdveeavkelreqR........pgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvkl
0039614 (Phosphotyrosine protein) phosphatases II 13-204 7.4e-35 116.2 In-house 48-294 (297) alignment 
Range on Protein: 13-204
Range on HMM: 48-294/297.0
TKASRKLVSENKRRYL--------------QDGFDLDLTYV-----------TDRIIASSFPSSG-----KQSIYRNPISEVS-----------------
.. ... .. .|.||                ||.|||..|.           |...||...|...      . .... .. .                  
ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywp

-----------RFLNTKHPDHYKVINLCSERhYDESYFNHQVIRVQTDDHNVP-KLEELLKFSKIAKEWMEAD-PKNVMFIHCKGGKGRTGTAVCTWLLE
           ..|...| |.|.| .|. .. ..||.. ...  .   ||.||  || ||.| ....|..... ..... .||..|.||||| .. .|. 
eeggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylml

----SEAFQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQVKFKYGGQ
    .|   ...|..... ..|         ..|||||| |.......  .|.. .
eqlekeggvdvleavkelreqR........pgavqtpsqyrflydallellkrklt
0043336 (Phosphotyrosine protein) phosphatases II 13-196 7.5e-30 99.8 In-house 37-274 (278) alignment 
Range on Protein: 13-196
Range on HMM: 37-274/278.0
TKASRKLVSENKRRY-------------LQDGFDLDLTYV----------TDRIIASSFPSSGKQSIYRNPISEVS------------------------
.. .... . .|.||               .|.|||..|.          ....||...|...    ... . |                          
ysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpg

----------RFLNTKHPDHYKVINLCSER-HYDESYFNHQVIRVQTDDHNVP-KLEELLKFSKIAKEWMEaDPKNVMFIHCKGGKGRTGTAVCTWLL--
          ..|...| |.|.|..|. ..  ..||.. ...  .   ||.||  |. ||.| |...|..| |..... .||..|.||||| .. .||  
gsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllle

--ESEAFQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQ
  |.| . .. |..... ..|        .. |||||| |.......
qlekeggvdleeavkelreqR........pgavqtpsqyrflyeall
0046845 (Phosphotyrosine protein) phosphatases II 15-203 7.7e-28 93.1 In-house 22-278 (284) alignment 
Range on Protein: 15-203
Range on HMM: 22-278/284.0
ASRKLVSENKRRYLQ-----------------------------DGFDLDLTYVTDRIIASSFPSSG-----------------------------KQSI
.....   .| || .                             ||.||||||.. ..|| ..| ..                             | . 
vallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaq

YRNPISEVSRF-------LNTKHPDHYKVINLCSERH--YDESYFNHQVIRVQTDDHNVPK-LEELLKFSKIAKEWMEA-DPKNVMFIHCKGGKGRTGTA
|.....|| ..       |.... |.|.|..|. ...   .||.. ..    .  ||.||  .| ||.| ....|..|. ...... .||..|.||||| 
YwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtf

VCTWLLESEA-------FQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQVKFKYGG
.. .|| .           .. |.. .. ..|        .. |||..| |.|... .  .|.. 
ialdllleqlekeglllgvdvleavkrlreqR........pgmvqtleqyrfvyealleylklkl
0045450 (Phosphotyrosine protein) phosphatases II 15-197 2e-27 92.2 In-house 49-302 (307) alignment 
Range on Protein: 15-197
Range on HMM: 49-302/307.0
ASRKLVSENKRRYLQ-------------------------------------DGFDLDLTYV----------------------------------TDRI
....... .|.||                                       ||.||.....                                  ....
iallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrek

IASSFPSSGKQSIYRNpisEVSRFLNTKHPDHYKVINLCSERHyDESYFNHQVIRVQT---DDHNVPK-LEELLKFSKIAKEWMEAD-PKNVMFIHCKGG
.|  .|..| .  |.|    . ..|...| |.|.| .|. ... |.. . ..|.  .     ||.||. .||||.| .......|.. ..... .||..|
caqywPdegeeltygn...ftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaG

KGRTGTAVCTWLLESEA-------FQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQV
.||||| .. .|. .         . .. |..... ..|         ..||.|.| |....... 
vgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR........pgavqnpeqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 16-197 4.1e-31 103.8 In-house 5-240 (243) alignment 
Range on Protein: 16-197
Range on HMM: 5-240/243.0
SRKLVSENKRRYL--------------QDGFDLDLTYVTDRIIASSFPSSG---------KQSIYRNPISEVS---------------------------
...... .|.||                | ....|.|||.|.||...| ..          . .... |. .                            
allpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdft

-RFLNTKHPDHYKVINLCSER--HYDESYFNHQVIRVQTDDHNVPK-LEELLKFSKIAKEWMEA-------DPKNVMFIHCKGGKGRTGTAVCTWLLESE
 ..|...| |.|.| .|. |.  ..|........ ..   ||.||   | ||.| ....|..|.       |..... .||..|.||||| .. .|. . 
vtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll

AFQTAKECLDFFGSRRTDldegdkfQGVQTPSQSRYVHYFEQV
   .. |..... ..|          .|||||| |....... 
lgvdleeavkllreqRpg.......kavqtpsqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 16-196 1.8e-28 95.1 In-house 4-240 (245) alignment 
Range on Protein: 16-196
Range on HMM: 4-240/245.0
SRKLVSENKRRY-------------LQDGFDLDLTYV----------TDRIIASSFPSSGKQS-----IYRNPISEVS----------------------
...... .|.||               ||.|||..|.          |...||...|...        .... |. .                       
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

--------RFLNTKHPDHYKVINLCSER-HYDESYFNHQVIRVQTDDHNVPK-LEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTWLL----
        ..|...| |.|.| .|. ..  .||| ..... ..  .||.||  || ||.| .........|.......||..|.||||| .. .|.    
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

ESEAFQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQ
|.|   .. |..... |.|         . |||||| |.......
ekelgvsleeavkelrsqR........pgavqtpsqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 16-197 8.9e-27 89.7 In-house 6-244 (249) alignment 
Range on Protein: 16-197
Range on HMM: 6-244/249.0
SRKLVSENKRRYL---------------QDGFD--------LDLTYVTDRIIASSFPSSGKQSIYRNPISEVS---------------------------
...... .|.||                ...|.        .|..|...|.|| ..| ..  . ... . |                             
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

--------RFLNTKHPDHYKVINLCSERHYDESYFNHQVIRV-QTDDHNVP-KLEELLKFSKIAKEWMEAD-PKNVMFIHCKGGKGRTGTAVCTWLL---
        ..|.... |.|.| .|. ...|| . .  ..|..    ||.||  .|.||.| .......|.. .......||..|.||||| .. .|.   
leygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleq

-ESEAFQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQV
 | |   ...|..... |.|        ...||.|.| |....... 
lekelgvdleeavkllrsqR........pgavqnpeqyrflyealle
subfamily_PTEN_pd Subfamily PTEN 17-197 1.4e-65 215.7 In-house 3-178 (184) alignment 
Range on Protein: 17-197
Range on HMM: 3-178/184.0
RKLVSENKRRYLQDGFDLDLTYVTDRIIASSFPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINLCSERHYDESYFNHQVIRVQTDDHNVPKLEELLKFS
||.||..|.|. .||.||||.|.|..||| ..|. . ...||| ...| .||..|| ||||..||.|||.||.. |...|. .. |||| |.|| | .. 
rkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeiv

KIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQTAKECLDFFGSRRTDLDegdkfQGVQTPSQSRYVHYFEQV
. ...|.|.|.|||. .||| ||||||. ....||.|  ...|.| |..| . ||  .     .||. ||| |||.|.|..
ediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk.....kgvtiPsqrRYveYyekl
PTEN_1 17-197 2.3e-42 140.0 In-house 3-191 (196) alignment 
Range on Protein: 17-197
Range on HMM: 3-191/196.0
RKLVSENKRRYLQDGFDLDLTYVTDRIIASS-FPSSG-----KQSIYRNPISEVSRFLNTKHPDH-YKVINLCSERHY------DESYFNHQVI--RVQT
|.  . .|.........|||||.|.||||.. .|| .      .. ||.....|...|.....|. . |.||..|...      .|..|...|.  ..  
rlskrsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpi

DDHNVPKLEELLKFSKIAKEWMEADP-KNVMFIHCKGGKGRTGTAVCTWLLESEAfQTAKECLDFFGSRR-TDLDEgdkfqgvqTPSQSRYVHYFEQV
.||..| |.||... | ..||. .|| .||  .|||.|.||.|| |. .|....   ||.| |... ..|     .        .||| |...||.. 
eDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn........spsqerlleyfael
0044763 (Phosphotyrosine protein) phosphatases II 20-204 1.3e-22 75.7 In-house 7-176 (178) alignment 
Range on Protein: 20-204
Range on HMM: 7-176/178.0
VSENKRRYLQDGFDLDLTYVTDRIIASSFPSsgkqsiyrnpiSEVSRFLNTKHPDHykVINLCSE--------RHYDESYFNHQVIRVQTDDHNVPK-LE
|. .....|. .. .............|.|.           ..  ..|   . .|  ..||..|         .|. . .. |.... ..||.||  ||
vllsnleglersdyinaseilpglylgslpp...........addlellkelgith..ivnlteelelgflkcdpywpeeagiqylhipipDhgvpdlle

ELLKFSKIAKEWMEADPkNVMFIHCKGGKGRTGTAVCTWLLESEAFqTAKECLDFFGSRRtdldegdkFqGVQTPSQSRYVHYFEQVKFKYGGQ
 .|.| .. .|... .. .. ..||. |.||.|| |. .|. .  . .. |..... .||        . .|..|.| |....||.  .|.. .
hflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR........p.ivpnpgqlrqLyefelrllkesdl
subfamily_Tensin_pd Subfamily Tensin 25-197 5.8e-48 155.9 In-house 2-170 (189) alignment 
Range on Protein: 25-197
Range on HMM: 2-170/189.0
RRYLQDGFDLDLTYVTDRIIASSFPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINLcSERHYDESYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWME
 ||... .||||||.|.|||| |||..|... ||. . .|...|..|| |.| | || ||..|| | .|..|. .   |.  | || |    |  ..|..
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

ADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQTAKECLDFFGSRRTdldEGDKFQGVQTPSQSRYVHYFEQV
|||.||. .||||||||.|  | ...  |.  ..|.. || |  .|      || .|.. ||| |||.||...
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrf...lddklsgetqPsqrryveyfsgl
0041856 (Phosphotyrosine protein) phosphatases II 25-206 1.8e-32 107.8 In-house 5-178 (182) alignment 
Range on Protein: 25-206
Range on HMM: 5-178/182.0
RRY---LQDGFDLDLTYVTDRIIASSFPSSGKQSIYRNPISEVSRFLNTKHPDHYK-VINLCsERHYDESYFNH---QVIRVQTDDHNVPKLEELLKFSK
.||   |   ...||.|........|.|..     .....|.| .||.. .  ... ..||. |..|. .....   |..... .||.|| |.|||.| .
nrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfie

IAKEwmeadPKNVMFIHCKGGKGRTGTAVCTWLLESEAfQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQVKFKYGGQIP
...|     .... ..||..|.||||| |. .|...    .. |..... |||        ...|.||.| .......  ..... ..|
evle.....eggpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR........pgmvitpnqyfflqlallellllkktrp
0043147 (Phosphotyrosine protein) phosphatases II 26-204 1.9e-31 104.5 In-house 5-166 (172) alignment 
Range on Protein: 26-204
Range on HMM: 5-166/172.0
RYLQDGFDLDLTYVTDRIIASSFPssgkqsiYRNPISEVSRFLNTKHPDHykVINLCSE--RHYDESYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWM
..  . ..|||.|..||.||  .|       .||..... |.| ... .|  ..||...    .... .. |....  .||.|| || ||.| .. .|..
sdyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidell

EADPKNVMFIHCKGGKGRTGTAVCTWLLEseAFQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQVKFKYGGQ
  .|.... .||..|.||||| |. .|..     .. |..... ..|        ...||.||| |...|||.  . ....
alspggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR........pgavqnpsqyrflyyfeklllllkds
0046846 (Phosphotyrosine protein) phosphatases II 26-197 2.6e-30 100.9 In-house 2-171 (176) alignment 
Range on Protein: 26-197
Range on HMM: 2-171/176.0
RYLQDGFDLDLTYVTDRIIASSFPSSGKQSIYRNPISEVSRFLNTkhpDHYKVINLCSERHY--------D--ESYFNHQVIRVQTDDHNVPKLEELLKF
|....|.||||.|.....|..|.|  .  ...|.  . . ....    ... |.||..|...           .  ...|.... ..||.|| || ||..
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllel

SKIAKEWMEADpkNVMFIHCKGGKGRTGTAVCTWLLESEAFQTAKECLDFFGSRRTDldegdkfQGVQTPSQSRYVHYFEQV
 .. .|. ...  ..  .||..|.||||| |. .|||.| . .. |.|... ..|         . ||||.| |....||. 
lefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl.......gavqtpeQyrflyefell
0036282 (Phosphotyrosine protein) phosphatases II 31-196 1e-40 134.6 In-house 7-167 (174) alignment 
Range on Protein: 31-196
Range on HMM: 7-167/174.0
GFDLDLTYVTDRIIASSFPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINLCSERHYDESYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEADPKNV
 ..|||.|.|.|.||...| .  . .... |. | ..|. |....||.||...|...|.. ...|.... ..||.|| |..||.| |...|... ||...
aspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

MFIHCKGGKGRTGTAVCTWLLESEAFQTAKECLDFFGSRRTDldegdKFQGVQTPSQSRYVHYFEQ
. .||..|.||||| |. .|..   .... . ||.. ..|.      . ..|||||| |...|||.
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq.....rpgmvqtpsQyrflyyfek
0045098 (Phosphotyrosine protein) phosphatases II 31-202 4.5e-23 77.5 In-house 4-275 (278) alignment 
Range on Protein: 31-202
Range on HMM: 4-275/278.0
GFDLDLTYVTDRIIASSFPSSGKQSIYRNPIS--------------------------------------------------------------------
...|||.. ...... ..||.   ..|.....                                                                    
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

-----------------------EVSRFlNTKHPDHYKVINLCSERHYDESYFNHQVIRVQTDDHNVPKLE---ELLKFSKIAKEWME------------
                       ..... .. .  ...|.||..||...||.. ...  .  .||.|| |.    .|.. .  .|...            
ekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

ADPKNVMFIHCKGGKGRTGTAVCTWLLESE--AFQTAKECLDFFGSRRtdldegdkFQ-GVQTPSQSRYVHYFEQVKFKYG
 |.......||. |.||||| |. .|. .      .. |..... |.|         .  ||...| |....|..  ...|
ldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR........pglavqnleqyrflyefllelllrg
subfamily_Auxilin_pd Subfamily Auxilin 33-196 2.3e-40 131.0 In-house 8-162 (166) alignment 
Range on Protein: 33-196
Range on HMM: 8-162/166.0
DLDLTYVTDRIIASSFPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINLcSERHYDESYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEADPKNVMF
|||..|.| |||  |||. | .| |.| | .|. ||...||..|.|.|| |.|.|... .. .|. ..   ...|.||.|.. ..    |...|||||. 
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKGGKGRTGTAVCTWLLESEAFQTAKECLDFFGSRRTDLDegdkfqgvQTPSQSRYVHYFEQ
.||| |.  ... |...|.  ............|  .|.  .         .||. ||..|. .
vhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig........lspsekryleylad
0051082 (Phosphotyrosine protein) phosphatases II 34-195 1.5e-22 75.2 In-house 6-148 (151) alignment 
Range on Protein: 34-195
Range on HMM: 6-148/151.0
LDLTYVTDRIIASSFPSSgkqsiyrnpisEVSRFLntKHPDHYKVINLCS--ERHYDESYFNH---QVIRVQTDDHNVPKLEELLKFSKIAKEWMEADPK
....|||.....|..|..           .. ..|  |. ... ..||.|  || |. .|..    .|.... .|. .|.|...... . . |.......
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVMFIHCKGGKGRTGTAVCTWLLEseAFQTAKECLDFFGSRRTdldegdkfqGVQTPSQSRYVHYFE
.....||..||||||| |. .|.      .. |.|... ..|.         || .|.| .....|.
gpvlvHCsaGkgRTGtlvalylml..lgvsleealeeyrlkrp.........gvvqpnqqflfqlfa
0038934 (Phosphotyrosine protein) phosphatases II 38-203 9.7e-36 118.6 In-house 15-175 (194) alignment 
Range on Protein: 38-203
Range on HMM: 15-175/194.0
YVTDRIIASSFPSSG-----KQSIYRNPISEVSRFLNTKHPDHYKVINLC-SERHYDESYFNHQVIR---VQTDD-HNVPKLEELLKFSKIAKEWMEADP
..|.|.|| ..|.||      ...||.... . |.|.... ....||.|. .|| || ..|    |.    .. | ..|| || ||.| ....|....||
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

KNVMFIHCKGGKGRTGTAVCTWLLESEAFqTAKECLDFFGSRRtdldegdkfqgvqtPSQSRYVHYFEQVKFKYGG
..|  .|||.|.||||| |. .|...  . .|.|....| ..|              |.. ....|.|..   |. 
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR..............pgaipnqdyleallkryke
0049772 (Phosphotyrosine protein) phosphatases II 41-200 1.3e-20 69.8 In-house 60-281 (314) alignment 
Range on Protein: 41-200
Range on HMM: 60-281/314.0
DRIIASSFPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINL-----------------------------------------------------------
 | |....| ||   |  . .. . .|. |..|  . |...                                                           
nrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngnept

-------CsERHYDESYFNHQVIRV---QTDDHNVPKLEELLKFSKIAKEWmeaDPKNVMFIHCKGGKGRTGT-AVCTWLLESEAFqTAKECLDFFGSRR
       . |..|| ..| ...|..    ..|...| || ...| .. .|.   |.... ..|||.||||||| .|. .|.    . ...|.|... ..|
aadlellk.eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkR

TdLDEGDKFQgvQTPSQSRYVHYFEQVKFK
.     . |   ... |  ..... . ..|
p.inpnpgfi..eqleqyefilealleylk
subfamily_CDC14_pd Subfamily CDC14 41-166 5.3e-08 27.1 In-house 178-300 (328) alignment 
Range on Protein: 41-166
Range on HMM: 178-300/328.0
DRIIASSFPSSGKQSIYRNPISEVSRFLNT-KHPDHYKVINLcSERHYDESYFNHQVIRV---QTDDHNVPKLEELLKFSKIAKEWmeadpKNVMFIHCK
|...| . | . ..   . |. .  ..|.  .. .  .|. |  .. ||.. |... .        |  .|. . . || .||..      .  . .|||
dkflalagPhnkskledgyplhaPeklleyfrknnvttvvrL.nkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCk

GGKGRTGTAVCTWLLESEAFqTAKECLDFF
 | ||||| . ..|..   | ||.|.. ..
aGLGrtGtLiacylmkhyrf.taaeaiawl
0049260 (Phosphotyrosine protein) phosphatases II 45-196 2.6e-28 94.0 In-house 6-147 (152) alignment 
Range on Protein: 45-196
Range on HMM: 6-147/152.0
ASSFPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINLCSERHYDESYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGT
| .|.  . | ...|..... |.| . . ... ... ..|....  ..  |.......||.||.|..||.|  .. |..  |.... ..||..|.|||||
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

AVCTWLLEseAFQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQ
 |. .|..     ...|..... ..|         ..|..|.| |....||.
lvaaylml..lgvsleeavalvrekR........pgavpnpgqlrflyefek
0048179 (Phosphotyrosine protein) phosphatases II 47-196 5.9e-25 83.1 In-house 2-142 (144) alignment 
Range on Protein: 47-196
Range on HMM: 2-142/144.0
SFPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINLCSERHYDESYFN-HQVIRVQTDDHNVPKL-EELLKFSKIAKEWMEadPKNVMFIHCKGGKGRTGT
|.||   ...|....  .... . |. ... ||||..|.....  .. .|.... ..||.|| | | ||.| .. .|..|  .......||..|.|||||
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgt

AVCTWLLESEAfQTAKECLDFFGSRRTdldegdkfQGVQTPSQSRYVHYFEQ
 |. .|.  .   ...|.|... |||         ..|..|.| |.....|.
lvaaylmkklg.lsleealalvrsrrp........gavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 48-197 3.1e-24 80.7 In-house 3-141 (145) alignment 
Range on Protein: 48-197
Range on HMM: 3-141/145.0
FPSSGKQSIYRNPISEVSRFLNTKHPDHYKVINLCSERHYDEsYFNHQVIRVQTDDHNVPKL-EELLKFSKIAKEWMEADpkNVMFIHCKGGKGRTGTAV
.||   ...|....  .... . |. ... |.||.||... |  .. |.... ..||.|| | | ||.| .. .|.....  .....||. |.||||| |
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CTWLLESEAfQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQV
. .|. ..   .. |.|... |.|        ...|..|.| |....||. 
aaylmlllg.vsleealelvrsqr........pgavpnpgqlrflyefele
0036941 (Phosphotyrosine protein) phosphatases II 48-210 2.1e-18 62.1 In-house 124-288 (297) alignment 
Range on Protein: 48-210
Range on HMM: 124-288/297.0
FPSSGKQSIYRNPIseVSRFLNTKH--PDHYKVINLCSER-HYDESYFNHQVIRVQTDDHNVPK-LEELLKFSKIAKEWMEAD-PKNVMFIHCKGGKGRT
.|.   .|.. ...  . ..|....   |.|.. .|. .   ..||.. ..      .||.||   ..||.| . .......  ..... .||..|.||.
wpleegesltygdf..tvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

GTAVCTWLL----E---SEAFQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYFEQVKFKYGGQIPEPKD
|| .. .|.    |    |   . .|.. .. ..|        .. |||..| |.......  .|.. ..... .
gtfiaadlmlqqledklkeggvdileavkklReqR........pgavqtleqyrflyeallellkkkltkepllk
subfamily_RNGTT_pd Subfamily RNGTT 62-170 1e-12 42.1 In-house 42-154 (189) alignment 
Range on Protein: 62-170
Range on HMM: 42-154/189.0
SEVSRFLNTKHPDHYKVINLCS-ERHYDESYFNH---QVIRVQTDDHNV-PKLEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTWLLESEAF
|... .|.|..     ||.|   .|.||.. ...   . ...|.  . . |. |.  .| |. .|...  |..|. .||. |  |||  ....|.| | .
smllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedw

QTaKECLDFFGSRR
.  .. .. | . |
sv.eaavalFakaR
subfamily_PRL_pd Subfamily PRL 64-170 6.9e-08 26.7 In-house 23-130 (151) alignment 
Range on Protein: 64-170
Range on HMM: 23-130/151.0
VSRFLNTKHPDHYKVINLCSERHYDESYFNHQVIRV---QTDDHNVPKLEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCTWLLESEAfqTAK
...| .. .  . | .  . |  ||.. .... |.|   . || .||  | . .. .. ||  . .||... .||  | ||.   |.  |.|.    . .
lekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm..kye

ECLDFFGSRR
. ..|  ..|
davefirekr
DSPc_SM00195 64-151 2.4e-06 22.4 In-house 130-218 (263) alignment 
Range on Protein: 64-151
Range on HMM: 130-218/263.0
VSRFLNTKHPDHYKVINLCSERHYD-ESYFNHQVIRVQTDDHNVP-KLEELLKFSKIAKEWMEADpKNVMFIHCKGGKGRTGTAVCTWLL
|    ..|..|.... .|  . . . |... .|.   .  ||.|| . ...|.. . .|.. .   .. . .||. | ||||| |.. ..
vklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidii
PTPc_SM00194 64-151 2.4e-06 22.4 In-house 130-218 (263) alignment 
Range on Protein: 64-151
Range on HMM: 130-218/263.0
VSRFLNTKHPDHYKVINLCSERHYD-ESYFNHQVIRVQTDDHNVP-KLEELLKFSKIAKEWMEADpKNVMFIHCKGGKGRTGTAVCTWLL
|    ..|..|.... .|  . . . |... .|.   .  ||.|| . ...|.. . .|.. .   .. . .||. | ||||| |.. ..
vklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidii
0051299 (Phosphotyrosine protein) phosphatases II 66-193 3.7e-17 58.2 In-house 152-280 (288) alignment 
Range on Protein: 66-193
Range on HMM: 152-280/288.0
RFLNTKHPDHYKVINLCSER-----HYDESYFNHQVIRVQTDDHNVPK-LEELLKFSKIAKEWMEaDPKNVMFIHCKGGKGRTGTAVCTWLL----ESEA
..|.... |.|.| .|. ..       .||.. ..    .  ||.||  .|.||.| ........ ...... .||. |.||||| .. .||    | | 
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeg

FQTAKECLDFFGSRRtdldegdkFQGVQTPSQSRYVHY
  .. | . .. ..|        .. ||||.| |.|..
gvdvleavkrlreqR........pgmvqtpeqyrfvye
0047943 (Phosphotyrosine protein) phosphatases II 67-194 2.8e-19 65.1 In-house 141-267 (273) alignment 
Range on Protein: 67-194
Range on HMM: 141-267/273.0
FLNTKHPDHYKVINLCSER-HYDESYFNHQVIRVQTDDHNVP-KLEELLKFSKIAKEWMEAD-PKNVMFIHCKGGKGRTGTAVCTWLL----ESEAFQTA
.|.... |.|.| .|. .. ...||.. ...      ||.||  ||.||.| .......||.  .... .||..|.||||| .. .||    | |   ..
llseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdv

KECLDFFGSRRtdldegdkFQGVQTPSQSRYVHYF
.|.. .. |.|        . .||||.| |.....
leavkllrsqR........pgmvqtpeqyrflyea
0050432 (Phosphotyrosine protein) phosphatases II 68-194 3.6e-15 51.6 In-house 173-294 (308) alignment 
Range on Protein: 68-194
Range on HMM: 173-294/308.0
LNTKHPDHYKVINLCSER-HYDESYFNHQVIRVQTDDHNVPK-LEELLKFSKIAKEWMeadPKNVMFIHCKGGKGRTGTAVCTWLL----ESEAFQTAKE
|.... |.|.| .|. .   ..|| . ..       ||.||  .|.||.| .......   |.... .||. | ||||| .. .||    | |   .. |
lseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfe

CLDFFGSRRtdldegdkFQGVQTPSQSRYVHYF
.. .. ..|         . ||||.| ..... 
avkklReqR........pgmvqtpeqylflyra
subfamily_PTPRB_pd Subfamily PTPRB 70-168 7.8e-07 23.4 In-house 159-256 (293) alignment 
Range on Protein: 70-168
Range on HMM: 159-256/293.0
TKHPDHYKVINLCSERHYDESYFNhQVIRVQTDDHNVPK-LEELLKFSKIAKEWME-ADPKNVMFIHCKGGKGRTGTAVCTWLLESEaFQTaKECLDFFG
... ... . .|  |.. .|   . |   .   ||.||.  . ||.| .  .|..| .  |. . .||  | ||||| ..   | ..  .. ....| ||
eeeledwvirelkiekekeerkvr.qyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqa.iee.edyvdifg

S
 
i
subfamily_PTPMT1_pd Subfamily PTPMT1 76-171 3.9e-11 37.7 In-house 57-149 (171) alignment 
Range on Protein: 76-171
Range on HMM: 57-149/171.0
YKVINLC-SERHYDESyfNHQVIRVQTDDHN-VPKLEELLKFSKIAKEWMEAdpKNVMFIHCKGGKGRTGTAVCTWLLESEAFQtAKECLDFFGSRRT
|..  |. | ... .   . . ....| |.   |.||.|.|  .. .. ..   .. ...|||.|.||..| | ..|. .| ..  .| |..  ..| 
yelkalansteewkkl..gveqlqlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkkekls.peeAlkalkkkRk
subfamily_PTPN12_pd Subfamily PTPN12 76-167 2.3e-06 21.7 In-house 156-247 (290) alignment 
Range on Protein: 76-167
Range on HMM: 156-247/290.0
YKVINLCSERHyDESYFNHQVIRVQTDDHNVPK-LEELLKFSKIAKEWMEADPKnVMFIHCKGGKGRTGTAVCTWLL-ESEAFQTAKECLDFFG
. .  |  |.. .||   .|    .  ||.||.  ..||.. . ..|  |.. .  . .||  | ||||| .   .  |    .. .|.|| | 
flirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqeseda.PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfd
subfamily_DSP11_pd Subfamily DSP11 78-171 1.1e-10 35.8 In-house 60-158 (178) alignment 
Range on Protein: 78-171
Range on HMM: 60-158/178.0
VINLC-SERHYDESYFNHQV---IRVQTDDHNVPKLEELLKFSKIAKEWME--ADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQTaKECLDFFGSRRT
||.|   .|.|... ....     ....  |.||| | . ||..  ||..|  .| .... .||  |  |||  .| .|.. | ... .. .. | . | 
vidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyep.edaieafeearG
DSPc Dual specificity phosphatase, catalytic domain 78-180 1.6e-09 32.8 Pfam-A 22-124 (133) alignment 
Range on Protein: 78-180
Range on HMM: 22-124/133.0
VINLCSERH--YDESYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEADPKNVmFIHCKGGKGRTGTAVCTWLLESEAFqTAKECLDFFGSRRTDLDE
|||. .| .  .. .  . . .|.. .|..  |... |. ..   | .|.. |.| ..||. |  |..| .. .|.... . ...|...|. .||  . .
vinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskisp

GDKFQ
 ..|.
nagfl
DSPc Dual specificity phosphatase, catalytic domain 78-180 1.6e-09 32.8 In-house 22-124 (133) alignment 
Range on Protein: 78-180
Range on HMM: 22-124/133.0
VINLCSERH--YDESYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEADPKNVmFIHCKGGKGRTGTAVCTWLLESEAFqTAKECLDFFGSRRTDLDE
|||. .| .  .. .  . . .|.. .|..  |... |. ..   | .|.. |.| ..||. |  |..| .. .|.... . ...|...|. .||  . .
vinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskisp

GDKFQ
 ..|.
nagfl
PTPc_motif_SM00404 78-179 4.5e-07 24.8 In-house 31-130 (140) alignment 
Range on Protein: 78-179
Range on HMM: 31-130/140.0
VINLCSERHYDESYFNHQVIRVQTDD-HNVPKLEELLKFSKIAKEWmEADPKNVmFIHCKGGKGRTGTAVCTWLLESEAFQTaKECLDFFGSRRTDLDEG
|||. .|   ...  . |..... || .. . ...| |  .. ..  |.. ..| ..||. |  |..| .. .|.... ... .|...|. .||  ... 
vinvteevsltkensgfqilqiplddnekdklskyldkvldfiena.ekkggkv.lVHCqaGvSRSatliiaYlmryrqlsl.aeayefvkerRpiispn

DKF
 .|
lnf
0051429 (Phosphotyrosine protein) phosphatases II 79-196 7.3e-10 34.5 In-house 50-222 (272) alignment 
Range on Protein: 79-196
Range on HMM: 50-222/272.0
INLCSER----------------------------------------------------------HYDESYFNHQVIRVQTDDHNVPKlEELLKFSKIAK
..|.||                                                           ...|..  ..    .  ||.||. |.||.. ..  
vdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellelll

EwmeadpKNVMFIHCKGGKGRTGTAVCTWLLEsEAFQTAKECLDFFGSRRTDLDE-------GdkFQGVQTPSQSRYVHYFEQ
.      .. . .||..||.||||.|. .||  . .     . |.  .. . ..            . |||. | .... ...
d......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqr..pgavqteeqylflyeall
subfamily_DSP23_pd Subfamily DSP23 86-159 6.1e-08 27.5 In-house 44-115 (148) alignment 
Range on Protein: 86-159
Range on HMM: 44-115/148.0
HYDESYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEAdpKNVMFIHCKGGKGRTGTAVCTWLLESEAFQTA
   |.  |  . |.. ||.  | ||.. .| .. .|  |   .. . .||  |.||||| .  .|.  . . .|
phveatpnltlvrlriddyhppaleqvvefvrvveeaeek..neavsvhcllgrgrtgtmlacylvkerklaaa
subfamily_MKPLT_pd Subfamily MKPLT 89-171 7.3e-06 19.6 In-house 59-141 (164) alignment 
Range on Protein: 89-171
Range on HMM: 59-141/164.0
ESYFNHQV--IRVQTDDHNVPKLEELLKfsKIAKEWME-ADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFqTAKECLDFFGSRRT
 . | . |   .|...|   ..| . |.  ..||   .  |    ...||  || |. ..   .|..|. . | ||  ...  ||.
kdafpksveYlqvkvedesdeqlssfle..raakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw.tlkeayeylkerrs
subfamily_MKPLV_pd Subfamily MKPLV 89-171 7.3e-06 19.6 In-house 59-141 (164) alignment 
Range on Protein: 89-171
Range on HMM: 59-141/164.0
ESYFNHQV--IRVQTDDHNVPKLEELLKfsKIAKEWME-ADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFqTAKECLDFFGSRRT
 . | . |   .|...|   ..| . |.  ..||   .  |    ...||  || |. ..   .|..|. . | ||  ...  ||.
kdafpksveYlqvkvedesdeqlssfle..raakfladaidsGGrvlvhcvqGksrsssvtvafLikskgw.tlkeayeylkerrs
PTPlike_phytase Inositol hexakisphosphate 90-147 5.9e-06 21.0 Pfam-A 89-143 (149) alignment 
Range on Protein: 90-147
Range on HMM: 89-143/149.0
SYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEadpKNVMFIHCKGGKGRTGTAVC
. |. . .|.   |.. |. |.. .| .. |. ..   .. . ..|. |.||| ||. 
egfgvkYvRipitdeqapeeedvDafvrlikslpr...dtalvfnCqaGrgRTTtamv
PTPlike_phytase Inositol hexakisphosphate 90-147 5.9e-06 21.0 In-house 89-143 (149) alignment 
Range on Protein: 90-147
Range on HMM: 89-143/149.0
SYFNHQVIRVQTDDHNVPKLEELLKFSKIAKEWMEadpKNVMFIHCKGGKGRTGTAVC
. |. . .|.   |.. |. |.. .| .. |. ..   .. . ..|. |.||| ||. 
egfgvkYvRipitdeqapeeedvDafvrlikslpr...dtalvfnCqaGrgRTTtamv
Y_phosphatase Protein-tyrosine phosphatase 92-157 7.3e-06 20.9 Pfam-A 134-199 (235) alignment 
Range on Protein: 92-157
Range on HMM: 134-199/235.0
FNHQVIRVQTDDHNVP-KLEELLKFSKIAKEWMeADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQ
  .|.   .  ||.|| . ..||.. .  ...  .. .. . .||. | ||||| |. ..| ... .
evkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea
Y_phosphatase Protein-tyrosine phosphatase 92-157 7.3e-06 20.9 In-house 134-199 (235) alignment 
Range on Protein: 92-157
Range on HMM: 134-199/235.0
FNHQVIRVQTDDHNVP-KLEELLKFSKIAKEWMeADPKNVMFIHCKGGKGRTGTAVCTWLLESEAFQ
  .|.   .  ||.|| . ..||.. .  ...  .. .. . .||. | ||||| |. ..| ... .
evkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea
PTPc_DSPc_SM00012 94-166 1.1e-08 30.6 In-house 3-76 (105) alignment 
Range on Protein: 94-166
Range on HMM: 3-76/105.0
HQVIRVQTDDHNVPK-LEELLKFSKIAKEWMEADP-KNVMFIHCKGGKGRTGTAVCTWLLESEAFQTAkECLDFF
...   .  ||.||.  ...|.. .  |.....   .. . .||. | ||||| |.  .| .   ..  ...|.|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdif
subfamily_PTPDC1_pd Subfamily PTPDC1 97-172 1e-08 29.8 In-house 86-157 (182) alignment 
Range on Protein: 97-172
Range on HMM: 86-157/182.0
IRVQTDDHNVPKLEELLKFSKIAKEWMEADpknVMFIHCKGGKGRTGTAVCTWLLESEAFqTAKECLDFFGSRRTD
  .  .|..|. ||..|   |...  .. .    . .||  |.||||  ....|. .. . ||.. ...  |.|..
ynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrl.taekaiklvrskrpk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 100-148 4.8e-06 20.9 In-house 179-228 (281) alignment 
Range on Protein: 100-148
Range on HMM: 179-228/281.0
QTDDHNVPK-LEELLKFSKIAKEWMEADPKNVMFIHCKGGKGRTGTAVCT
.  || ||.  .|||.| |  ..  | . |  . |||  | ||||| .  
aWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyial
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 207-344 2.3e-26 83.5 Pfam-A 2-134 (134) alignment 
Range on Protein: 207-344
Range on HMM: 2-134/134.0
EPKDLIIENIRIRNLAGLGKGDGRDLYFEIICSNKKVFdcrF-ENGLNCQSIYdhASDSLSARIPHCPVLHGDVKIRFKSSSRKvpEDYDNCAFFFWFHT
.|| | . .|... .  . ...| .......  .||||     ..  . .. .  . ..    .|.  .. |||...| ... |    .... | .||.|
npkrlelksiilegiPnfktrggckpkvkvyngkkkvf...kelasykdster..raktfivkepnrlpveGDvlveflhkdsk..lpkkekifrvwFNT

AFIT--DNRLFLPRDELDNPHKSKaRKIYSESFNVEVQFSE
.||   .|.| ||..|||...| |  | .|. |.||..|..
sFieknqnvltlpkneLDkalkdk.dkkfsknfkvelvfek