Gene SpurPTP-Un-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP048_AA protein Get Run
SpurP048_AA_648-935 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 645-932 9.1e-40 131.5 In-house 7-277 (315) alignment
Range on Protein: 645-932
Range on HMM: 7-277/315.0
PSHTLTSNALAKFYSYREAIAEEFENLPGHQLIAsSDIKKRIAVpvTSKPRSPVIQSPERTRVPIPPTSptspsipSKPSDFFLDASFIRGYDSSHcSYI
|   | .    |  | .. . ...|..|| ||    |. |.|      | |   | . ...|| .| .         .|   ...|.|| ||.  .  ||
pldqlityvaqkkastkngfkqdyesipggqlhp.ldvakkien..kqknryiniiaydksrvqlplle.......ndphsdyvnanfidGynkkr.ryi

GATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKeggpgTQLYGNILVTLKGGASGEHYFTSTLliRNVEKSLCRPVTHYWFSNWLDS
.|      |   ||| |.|..  .|| | .  |  |  . .||| |       .||.| ||.|     ..|   ||    | ..  | |  . .. | |.
aaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdm

EIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYE
..| .  .|| .  .|.  |..| |..|||||.||||||  |. |  ....|  . .|. . .  .|| | ...  ..|| ||| .| |
gvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle

0051299 (Phosphotyrosine protein) phosphatases II 649-933 1.1e-60 200.9 In-house 10-285 (288) alignment
Range on Protein: 649-933
Range on HMM: 10-285/288.0
LTSNALAKFYSYREAIAEEFENLPGHQLIasSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPptsptspSIPSKPSDFFLDASFIRGYDSSHCsYIGATV
|..  |..  .    ..|||| |.  .     ...  . .   .| |.. |   ...|| .        .... ... . .||.|.||....  .| .  
llklvlkllangltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLs.......vldgvegsdYinAsyidgynlkrk.fIatqg

SGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTkeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNV----EKSLCRPVTHYWFSNWLDS
   ..   ||| ||||..|.||.|....||| . |.||||.     |.. ||.| |||.   . ..| . || ..|.     .. .| |||... || | 
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

EIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
 .|.||..|...| .|.. .. . ||||||||.|||||| .|| |. ...||. ..||....|  .|. | ... . .|| |.|..|.|.
gvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0043336 (Phosphotyrosine protein) phosphatases II 649-933 9.1e-56 184.7 In-house 7-276 (278) alignment
Range on Protein: 649-933
Range on HMM: 7-276/278.0
LTSNALAKFYSYREAIAEEFENLPGHQLiasSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPtsptspsIPSKPSDFFLDASFIRGYDSSHCsYIGATV
|    | ...... .. .|||.|.  .|    ...  . .   .| |.. |   ...|| . .       ... ... .  ||.. ||. ..  .| .  
llkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsl.......lggdldsdYinAsyvdgynvprk.fiatqg

SGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPtkeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPS
   ..   ||| |||....|||.|... |||.| | ||||      |.. ||.. |||..  . ..| . || . |  .. .| ||||.. .| | ..|.
PlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe

SPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
|.. |...| .|..  . | |||.||||.||||||..|| .. ...||  ..||....|. .|. |..|. . .|| |.|. |.|.
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

0045450 (Phosphotyrosine protein) phosphatases II 654-933 5.7e-55 182.6 In-house 19-303 (307) alignment
Range on Protein: 654-933
Range on HMM: 19-303/307.0
LAKFYSYREAIAEEFENLPGHQLIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSptspsiPSKPSDFFLDASFI--------RGYDSsHCSYIG
| .  . .. ...||| |.  . . . ...    .   .| |.. |   ..||| . ...      .| ... . .||..         |||.    .| 
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssld......gsledsdYiNAsyvrvpllllldgydl.krkfIa

ATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNV-EKSLCRPVTHYWFSNWLDS
. .   ..   ||| .|||....||.|... |||.. |.||||..    ... |||. |||..    ..|   || . .  ...  | |||... .| | 
tqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde...geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

EIPSSPQALMSMLLQVHNTHQE--SYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT---VDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
 .|.|.. | ... .|.. ..|  . |||.||||.|||||| .|| .. ...||. .|   ||....|. .|. |..|. | .|| |.|. |.|.
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0040438 (Phosphotyrosine protein) phosphatases II 657-936 1.8e-56 187.1 In-house 13-278 (317) alignment
Range on Protein: 657-936
Range on HMM: 13-278/317.0
FYSYREAIAEEFENLPGHQLIassDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPtsptspsIPSKPSDFFLDASFIRGYDSSHCsYIGATVSGGDSSTA
..|   |. ||||.|.  .|    ...  . .   .| |.| |   ...|| . |       ... ... .  ||.. |.. ..  .| . .   ..   
lksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsp.......lggdldsdYInAsyvdgpnlkrk.fIatqgPlpntved

FWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTkeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSM
||| ||||....||.|... ||| . | ||||.     .|. ||.. |||..    ...   || . . ..| .| |||... .| |  .|.||. | ..
FwrmvweqgvtvivmLteleelgrekcaqYwpl....getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldf

LLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKF
| .|..  ... |||.||||.|||||| .|| .. ...||. ..||....|  .|. |..|. . .|| |.|. |.|. |.
leavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr

subfamily_CG42327_pd Subfamily CG42327 658-862 3.5e-103 339.6 In-house 1-193 (319) alignment
Range on Protein: 658-862
Range on HMM: 1-193/319.0
YSYREAIAEEFENLPghQLIASSDikkriAVPVTSKPRSPVIQSpertrVPIPPTSPTSPSIPSKPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAF
...||..||||..||  ||||..|     .||||||..|.||..     ||.|.|......|.....|..||||..||||....|||.|.||..|||..|
verredvaeefrdlP..qliarad.....evPvtskdksrvinv.....vPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdf

WRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGGPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFsNWLDSEIPSSPQALMSML
||||||||||.||.|....||| |||..|.||||....|.|||.|||||||......|..||||...|.|...|..||||. .||..|.|....||..||
wrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml

LQVHNT
|.|...
levrss

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 659-938 5.3e-48 158.7 In-house 20-287 (319) alignment
Range on Protein: 659-938
Range on HMM: 20-287/319.0
SYREAIAEEFENLPGHQLIassDIKKRIAVPVTSKPRSPVIQSPERTRVPIPptsptspSIPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFW
.    ...||..| . .     ....       .| | . | . .|||| ..       ... ...  ...|||| ||.  .  .| .     .    ||
tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvls.......eldgvegsdyinasfidgyqere.kfiatqaPlentiedfW

RTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEggpgTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSL-CRPVTHYWFSNWLDSEIPSSPQALMSML
| |||..| ..| |.   | .|| . .|||...     . ||...|||.     |.|  . | ...    . .| |.|. . .| | ..| . ..|. .|
rmvWeeessivvmltklveklkvklkkywpeen....feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

LQVHNTHQE-SYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKFLS
 ........ . ||.|||||.||||||  |. |. ..|..|  ..|. .||| .|  |   . . .|| ||| .| |. .. .
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

0050432 (Phosphotyrosine protein) phosphatases II 661-935 6.4e-61 201.7 In-house 41-300 (308) alignment
Range on Protein: 661-935
Range on HMM: 41-300/308.0
REAIAEEFENLPGHQLiaSSDIKKRIAVPVTSKPRSPVIQSPERTRVPIpptsptspsipsKPSDFFLDASFIRGYD-SSHCSYIGATVSGGDSSTAFWR
.  . |||| |.  .   . ...    .   .| |.. |   ...|| .            .... . .||...||.  . . .| .     ..   |||
lglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl............degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

TVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGGpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQ
 ||||..|.||.|....| | . |.||||...|| |.. ||.. |||.   . ..| . || ..|....  | |||... || |  .|.||..|...| .
mvweqnvrvIvmLtklvengrekcaqYwplelgg.gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

VHNTHQEsyGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
|......  ||.|||||.|||||| .|| |. ...||. ..||....|  .|. | ... . .|| |.||.|.|. |
vrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0036941 (Phosphotyrosine protein) phosphatases II 661-935 1.6e-58 193.7 In-house 12-278 (297) alignment
Range on Protein: 661-935
Range on HMM: 12-278/297.0
REAIAEEFENLPGHQLIASSDIKKRIavPVTSKPRSPVIQSPERTRVPIpptsptspsipSKPSDFFLDASFIRGYDSSHCsYIGATVSGGDSSTAFWRT
.  . .||| |. ..|. | .. ..      .| |.. |   ..||| .           ..... . .||.. ||| ..  .| .     ..   ||| 
lalllkefeellpllllgslsvallp..enleknRykdilpydhtRVkl...........ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrm

VWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTqlYGNILVTLKGGAS--GEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLL
||||....||.|....|||.. |.||||..||.. |  ||.. |||..  .   ..| . || . .....  | |||... .| |  .|.||. |.... 
vweqnvtvIvmltelvelgrekcaqywpleegeslt..ygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

QVHNTHQE--SYGPVVVHCSDGVGRTGLVIATDINMQRLE---ESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
.|.. ...  | |||.||||.||||.| .|| |. .|.||   . ..|||. .| ..|. | .|. . .|| |.|..|.|. |
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk

0039614 (Phosphotyrosine protein) phosphatases II 661-935 8.6e-57 188.2 In-house 31-290 (297) alignment
Range on Protein: 661-935
Range on HMM: 31-290/297.0
REAIAEEFENLPGHQLiassDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSptspsiPSKPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRT
.  . .|||.|.  .     |..    .   .| |.. |   ...|| . |         . ... .  ||.. |||     .| .     ..   ||| 
ktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkped......gvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

VWEQQSRTIVCLCSPYELGKVCPQYWPTKEGgpgtqLYGNILVTLKGGASGEHYFTSTLLIRNveKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVH
||||....||.|... |||. |.||||...|      ||.. |||..    ..|.. || ..|  ..  | |||... .| |  .|.|.. |...| .|.
vweqgvtvivmLtklvelgrkcaqywpeegg.....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvr

NTHQE--SYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
. ..|  . |||.||||.|||||| .|| .. ...||. ..||....|. .|. |..|. . .|| |.|. |.|. |
ealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

subfamily_PTPRA_pd Subfamily PTPRA 661-934 3.3e-44 146.1 In-house 31-295 (330) alignment
Range on Protein: 661-934
Range on HMM: 31-295/330.0
REAIAEEFENLPGHQLIASSDIKKRIAvpVTSKPRSPVIQSPERTRVPIPPTSPTspsipsKPSDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRT
 . . |||..||  .. |. .. ..       | | . |   . .|| ... . .      . || ...|||| ||   . ..| |     ..   ||| 
nklfreefnalPagpiqatlelaskee..nkeknrvvnilPydfsrvilsvkeGv......eesd.yinasfidGykekd.kfiaaqGPkeetvedfwrm

VWEQQSRTIVCLCSPYELGK-VCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEK----SLCRPVTHYWFSNWLDSEIPSSPQALMSM
.|||.| ||| |    |  .  | ||||..    |.  |||| |...     ..|    .|.... .       | |. . |  | |  .|. |. ....
iweqksativmltelkerkeekcaqywPde....GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkl

LLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFS
| .|....| | ||.||||| ||||||  |. |  ..|..  . ||. ..|...|. | | .    || |||..| |. 
lkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

0047943 (Phosphotyrosine protein) phosphatases II 662-933 7.7e-59 194.7 In-house 12-271 (273) alignment
Range on Protein: 662-933
Range on HMM: 12-271/273.0
EAIAEEFENLPGHQLiaSSDIKKRIAVPVTSKPRSPVIQSPERTRVPIpptsptspsipSKPSDFFLDASFIRGYDSSHCsYIGATVSGGDSSTAFWRTV
  ..|||| |.  .   . ...  . .   .| |.. |   ...|| .           . ... .  ||...||....  .| .     ..   ||| |
tllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl...........gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmv

WEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVH
|||..|.||.|....|||.. |.||||...|.  .. ||.. |||..  . ..| . || ..|.. . .| |||... .| |  .|.|.. |.... .|.
weqnvrviVmLtelvelgrekcaqYwplegge.lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

NTHQE--SYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
.....  | ||||||||.|||||| .|| |. ...||. ..||.. .|  .|. |  .. . .|| |.|..|.|.
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

subfamily_PTPN6_pd Subfamily PTPN6 662-935 6.8e-41 135.2 In-house 26-298 (306) alignment
Range on Protein: 662-935
Range on HMM: 26-298/306.0
EAIAEEFENLPGHQLIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPptsptspsIPSKPSDFFLDASFIR-GYDSSHCSYIGATVSGGDSSTAFWRT
. . ||||.|  ..     . |.   .  ..| |   |   . ||| .          || | . ...|..|.    .|..||| .  .  .  . ||| 
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk........epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

VWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGgpGTQlYGNILVTLKGGASGEHYFTSTLLIR-NVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQ
||...|| || .   .| ||  | .|||..|    .. ||.| ||     | ..|   .|..  . .|. .| | .| | .| |  .|..|.|....| .
vwqensrvivmttkevErgkekCarYWPdeee..kee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfled

VHNTHQESY----GPVVVHCSDGVGRTGLVIATDINMQRLEES---HTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
|.. ..|.     ||.|||||.|.|||| .| .|| .. .|..     .|| ..| |.|. | . .   .|| |.|... .. .
vnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

subfamily_PTPN23_pd Subfamily PTPN23 662-930 8.5e-40 131.4 In-house 15-276 (288) alignment
Range on Protein: 662-930
Range on HMM: 15-276/288.0
EAIAEEFENLPGHQLIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPptsptspsipsKPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTV
 |. ..|..|  .|   . .    ||   ..| ||  |   ...|| .            .  | ...|||...  .   ..| .      ..  ||. |
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...........gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVH
.||.|..||.| |. ||||  . .|||...|   |. .|.. ||||   . |..   .| ..  ...  . |.|  . .| .  .|.||. |. .| .|.
yeqkssviVmllskeelgkpkvdrYwPedkge..tvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

N----THQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT-VDIPHTVSSIRQDRGQAILNIDQYAFIYRTL
.    ....|  |.||||| ||||||..      .. ||. .  .||.. || .|..|   . . .|. | |   
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav

subfamily_Ptp69D_pd Subfamily Ptp69D 663-937 6.4e-46 151.9 In-house 23-289 (307) alignment
Range on Protein: 663-937
Range on HMM: 23-289/307.0
AIAEEFENLPGHQLIASSDIKKRIAvpVTSKPRSPVIQSPERTRVPIPPTSPTspsipsKPSDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVW
 .|.|.|.|. ..   |. . ..     . | |.. |.. ..||| ....  .      . || ...||||.||. .. ..| |          ||| ..
glakeyekLeareidkstkvsekke..nalknRyedikafDktRvkLkkingk......edsd.Yinasfikgykekk.kfiaaqdPveatigDfWRmia

EQQSRTIVCLCSPYELGKV-CPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKS-----LCRPVTHYWFSNWLDSEIPSSPQALMSML
||.. .|| |    |  .  |..|||       .. ||.|||.|    . ..|   .| . .....       | |. | . .| ||..| ....|. ..
eqevtlivmlsnlteknrkkcakYWpie....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkli

LQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKFL
 ||.. .. . .|.||||| ||||.|...| |. .|.|.. ..||| .||  .|..|   . ...|| |.|| | ..|.. 
eqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg

subfamily_PTPRG_pd Subfamily PTPRG 663-933 5.6e-42 138.7 In-house 20-286 (563) alignment
Range on Protein: 663-933
Range on HMM: 20-286/563.0
AIAEEFENLPGHQLIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTsptsPSIPSKPsDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVW
 ..||||.|  .    . |...  .     | |   | . .|.|| . |.    | . .|  | .. |..| ||  |.  .|..  .  |    ||| .|
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklspl....pgkkkkl.D.YinAnyidGyqksk.afiatqgplkdtfddFWrmiW

EQQSRTIVCLCS-PYELGKVCPQYWPTkeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRN--VEKS----LCRPVTHYWFSNWLDSEIPSSPQALMSM
||.. .|| .     .  . |..|||.     ... ||.. |||.       | . || |.|  ..|       . |..| ...| |   |...   ...
eqnvaiivmitnlvergrrkcdvYWPk....desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLif

LLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
  .   ....  ||.||||| ||||||  |. |  ...... ..|.. ...  ||  |   . ...|| |.. .| | 
vkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea

0046845 (Phosphotyrosine protein) phosphatases II 664-935 6.2e-60 198.3 In-house 2-275 (284) alignment
Range on Protein: 664-935
Range on HMM: 2-275/284.0
IAEEFENLPGHQLIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSPTspsipsKPSDFFLDASFIRGYD----SSHCSYIGATVSGGDSSTAFWR
. |||| |.  .   . ...  ...   || |.. |   ...|| . .....       ... . .||...|||     ... .| .     ..   |||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd......ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwr

TVWEQQSRTIVCLCSPYELGK-VCPQYWPTKeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVE-KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLL
 ||||..|.||.|... | |.  |.||||..    ... ||.. |||.     ..| . || ..|.. ..  | |||... .| |  .|.||. |...| 
mvweqnvrvIVmltelvengrekcaqYwple...gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflr

QVHNTHQ--ESYGPVVVHCSDGVGRTGLVIATDINMQRLEESH---TVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
.|.. ..  .. ||.|||||.|||||| .|| |. ...||. .   .||....|. .|. | ... . .|| |.|..|.|. |
lvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 665-932 2.2e-25 83.9 In-house 23-234 (392) alignment
Range on Protein: 665-932
Range on HMM: 23-234/392.0
AEEFENLPGHQLIASSDIKKRIAVPvtsKPRSPVIQSPERTRVPIPptsptspSIPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQ
.||| .||| ..   .  .| | ..   | |   |   ...|| .         |   | . .|.||.|...|. . .|| .      |   ||| |...
feefhdlpgpdiypqtvaqkeinlk...knryknilpydsarvkle.......viddipdsdylnasyipsfdnek.ayiasqgpnaaslddfwrmvfqe

QSRTIVCLCSPYELGkvcpqywptkeggpgtqlygnilvtlkggasgehyftstllirnvEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQ
.  ||. .    |                                                   .| |. . |..| |...|    .|. .. .|.  . 
nvttiamvtklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfG

ESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYE
.   |...||| ||||||.||. |  . . .... ||.   |. ||. |   .   .|||||| .. |
qythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 665-934 8.5e-21 68.8 In-house 14-269 (281) alignment
Range on Protein: 665-934
Range on HMM: 14-269/281.0
AEEFENLPGHqliASSDIKKRIAVPVTSK-PRSPVIQSPERTRVPIpptsptSPSIPSKPSDFFLDASFIRGYdSSHCSYIGATVSGGDSSTAFWRTVWE
 .|| ||||      ||.   .  ||  |  |   |   . .|| .         .| | |  .. | .||     .  || .     .. . ||| .|.
kqefsnlpgd...ppsdlctvfnqpvnnkknrylnipcldisrvql......kvkmpnknstdyihanyirsp.flkrgyiltqgpkketradfwrmiwq

QQSRTIVCLCSPYELGK-VCPQYWPTKEGgpGTQLYGNILVTLKGGASGEHYFTSTLLIrNVEkSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNT
... .|| ||   |  .  | .|.| .        . .. |. .  .  .   |. | .   |    | .||. . .| | ..| | . .. .| ...  
enttaivmlcqfletnrekcaeyfprnah..cclqfdklsvsyedstvnkslvttrlnl.sye.getrlithwlwkewpdwqvpessevmlkilrkirar

hqeSyGPVVVHCSDGVGRTGLVIATDINMQRLEESHTV-DIPHTVSSIRQ-DRGQAILNIDQYAFIYRTLYEFS
   |  | |.||| ||||.| ..| .| .| .    |. || . || .|   |  ..  ..|| .|.. | .| 
...s.tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 666-933 2.5e-43 143.4 In-house 26-282 (305) alignment
Range on Protein: 666-933
Range on HMM: 26-282/305.0
EEFENLPGHqlIASSDIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSPtspsipskPSDfFLDASFIRGYDSSHCsYIGATVSGGDSSTAFWRTVWEQQ
.....|. .    | |..|. |   ... ...... ..|...   .. .         || ...||.. ||..... || |     .  . |||...| .
aqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld........dsd.yinasyvdgykrkkk.yivaqgPlkntvadfWrliveek

SRTIVCLCSPYELGK-VCPQYWPTKEGGPgtQLYGNILVTLKGGASGEHYFTSTLLIRN-VEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTH
 .||| |.   | ||  | ||||.... .  . .|.. |.||  .. . |..  | | .  |..  | |..| . .| |  .| .. .|.|.. .|....
vstivmltklveggkdkCrqYWpesktek..kefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdq

QESYG-PVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
... | |..||||.||||||  || || ..||..  .||. . .  .|. | ... . ||| |..  | | 
kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel

DSPc_SM00195 681-933 4.2e-52 172.4 In-house 17-261 (263) alignment
Range on Protein: 681-933
Range on HMM: 17-261/263.0
DIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSPTspsipskPSDFFLDASFIRGYdSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK
.... .    .|| |.  |   ..||| ....  .       ... .. |..|.|. ..  .|| .     .    |||.|||.....||.|... | ||
etteaekkknksknRyknilpydhtrVklkkeekk.......egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

-VCPQYWPTKEggPGTQLYGNILVTLKGGASGE-HYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGV
  | .||| ..   |.. .|.| |.|.   . . .. . || ... .|.  | ||.|.. || |...|.|.. ....| .|......| ||.|||||.||
ekcdrywpees..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGv

GRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
|||| ....|| ...||| ..||| ..|...|. | ... . .||.|||... |.
gRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 681-933 4.2e-52 172.4 In-house 17-261 (263) alignment
Range on Protein: 681-933
Range on HMM: 17-261/263.0
DIKKRIAVPVTSKPRSPVIQSPERTRVPIPPTSPTspsipskPSDFFLDASFIRGYdSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK
.... .    .|| |.  |   ..||| ....  .       ... .. |..|.|. ..  .|| .     .    |||.|||.....||.|... | ||
etteaekkknksknRyknilpydhtrVklkkeekk.......egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

-VCPQYWPTKEggPGTQLYGNILVTLKGGASGE-HYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGV
  | .||| ..   |.. .|.| |.|.   . . .. . || ... .|.  | ||.|.. || |...|.|.. ....| .|......| ||.|||||.||
ekcdrywpees..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGv

GRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
|||| ....|| ...||| ..||| ..|...|. | ... . .||.|||... |.
gRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

0045098 (Phosphotyrosine protein) phosphatases II 682-933 1.2e-48 161.3 In-house 25-271 (278) alignment
Range on Protein: 682-933
Range on HMM: 25-271/278.0
IKKRIAVPVTSKPRSPVIQSPERTRVPipptsptspsipskpsDfFLDASFIRGYdssHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-K
|   . .   .| | . |.  ...||                 | ...||.|.||   .  .| .     .   .|||..||.....||.|.. .||| .
itpalylgnldknRykdilpydhsrVk................d.YINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

VCPQYWPTkeggPGTQLYGNILVTLKGGASGEHYFTSTLLIRNV----EKSLCRPVTHYWFSNWLDSEIPSSP--QALMSMLLQVHNTHQE---------
 |.||||      |.. ||.. |||.     ..| . |||..|.    |   .| |||... .| | ..||.|  . . ..| .... ...         
kcaqywpe....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

----SYGPVVVHCSDGVGRTGLVIATDINMQRLeEsHTVDIPHTVSSIRQDRGQ-AILNIDQYAFIYRTLYEF
    | |||.|||| |||||| ..| .. ...| | ..||....|. .|. |.. |. | .|| |.|. |.|.
llldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllel

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 687-936 4.6e-50 165.2 In-house 25-270 (274) alignment
Range on Protein: 687-936
Range on HMM: 25-270/274.0
AVPVTSKPRSPVIQSPERTRVPIPPTSPTspsipsKPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQY
    ..| |   |   |..|| . . |..      ..   ...| .|.|||  .  |. .        . ||| ....... || |    |  .  | .|
vfgsqtknryktilPnensrvllesesse......dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPTKEGGPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKslCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQES---YGPVVVHCSDGVGRTG
.|..|.   .. ||.. .. ..  . ..|   .|.....|.  .| |.|||...| | . | ....|....|.|.....|.    .||||||| |.||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

LVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKF
  ||..| ...|.|...||. ..|. .|.|||  . . .|| .|.|.|... | 
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr

subfamily_egg_pd Subfamily egg 691-940 3.1e-15 50.6 In-house 41-276 (307) alignment
Range on Protein: 691-940
Range on HMM: 41-276/307.0
TSKPRSPVIQSPERTRVPIpptsptspSIP-SKPSDFFLDASFIRGYdSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELgKVCPQYWPTK
  | ||. ..  . .|| .         ..  . .| |. |  ..|       .| |     ..   ||| |.... . || | |  |  . |. |||  
lekarskrvhckdssrvkl........elrrGqylddfihanrvkGk.pllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpka

EGGPGTQLYGNILVT-LKGGASGEHYFTSTLLIRnVEKSLCRPVTHYWFSNWLDSEIPSSPqalmsmlLQVHNTHQESYGPVVVHCSDGVGRTGLVIATD
|  .   . |.. .. ||     .  |. | |   |          .|  ..  |    ||       |.|    ..   ||||.. .|| ... ..| .
esdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqgdvnnssdvysp.......lrvlrklrnlskpvvvqdilGvskaatlvaie

INMQRLEESHTV--DIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKFLSSS
| .  |    ..   . ..|  .|. |  ..  . .| |.|| .  | . . .|
iallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigs

Y_phosphatase Protein-tyrosine phosphatase 692-931 2.2e-53 176.5 Pfam-A 3-234 (235) alignment
Range on Protein: 692-931
Range on HMM: 3-234/235.0
SKPRSPVIQSPERTRVPIpptsptspSIPSKPSDfFLDASFIRGYDsSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKE
.| |.. |   ..||| .        .  ..||| .  |....||. .. ..| .     ..   ||| ||......||.|.|  | | . |.||||..|
kknRykdilpydktrvkl........kgsegpsd.YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee

GGpgTQLYGNILVTLK-GGA-SGEHYFTSTLLIRNVEKS-LCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIAT
..  .. ||.| |.||       ..| ...| ... ...   | |..... || |...|.||..|.... .|....... ||||||||.|||||| ..| 
ee..sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

DINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLY
|| ...||. ..||. ..|...|. | ... ...||.|.|... 
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 692-931 2.2e-53 176.5 In-house 3-234 (235) alignment
Range on Protein: 692-931
Range on HMM: 3-234/235.0
SKPRSPVIQSPERTRVPIpptsptspSIPSKPSDfFLDASFIRGYDsSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKE
.| |.. |   ..||| .        .  ..||| .  |....||. .. ..| .     ..   ||| ||......||.|.|  | | . |.||||..|
kknRykdilpydktrvkl........kgsegpsd.YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee

GGpgTQLYGNILVTLK-GGA-SGEHYFTSTLLIRNVEKS-LCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIAT
..  .. ||.| |.||       ..| ...| ... ...   | |..... || |...|.||..|.... .|....... ||||||||.|||||| ..| 
ee..sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

DINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLY
|| ...||. ..||. ..|...|. | ... ...||.|.|... 
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0042113 (Phosphotyrosine protein) phosphatases II 693-933 7.1e-50 165.1 In-house 12-242 (245) alignment
Range on Protein: 693-933
Range on HMM: 12-242/245.0
KPRSPVIQSPERTRVPIPPtsptspsIPSKPSDFFLDASFIRGYDSSHCSYIGATVSGGdSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTkeg
| |.. |   ..||| ..|       ... . . .  ||.. ||. ..  ....  . . .  .||| .||....|||.|... |||.| |.||||.   
knrysdilpydhtrvklsp.......dggdldsdyinasyvdgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqywpl...

gPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQ-ESYGPVVVHCSDGVGRTGLVIATDIN
  ... ||.. |||..  . ..| . || . |. ..  | |.||.. .| |  .|.... | ..|  |..  .  | |||.||||.||||||..|| .. 
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

MQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
...||. ..|.....|  .|. |..|. . .|| |.|. |.|.
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

0040439 (Phosphotyrosine protein) phosphatases II 693-933 1.7e-49 164.0 In-house 14-245 (249) alignment
Range on Protein: 693-933
Range on HMM: 14-245/249.0
KPRSPVIQSPERTRVPIPPtsptspsIPSKPSDFFLDASFIRGYDSSHCsYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTkeg
| |.| |  ....|| . .       .|. . . . .||.| ||....  .| .     ..  .||| .||.....||.|.|. |||.  | ||||.   
knrypdilpydhsrvklsi.......lpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...

gPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQE--SYGPVVVHCSDGVGRTGLVIATDI
  |.. ||.. |||.   . ..| . || . |....  | |.|... .| |  .|.|.. |.... .|.. ..|  . |||.||||.||||||..|| ..
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

NMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
 ...||. ..||....|. .|. |..|. | .|| |.|. |.|.
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0037934 (Phosphotyrosine protein) phosphatases II 694-933 2.8e-45 150.1 In-house 14-241 (243) alignment
Range on Protein: 694-933
Range on HMM: 14-241/243.0
PRSPVIQSPERTRVPIpptsptspsipskPSDFFLDASFIRGYDsshcSYIGATVSGGDSSTA----FWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPt
 | . |   ...|| .             ... ...|..|....     .|   .   ..       ||| .||.....||.|....|||.. |.|||| 
nrysdilpydhsrvkl.............egsdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

keggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVE-KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQE--------SYGPVVVHCSDGVG
     |.. ||.. |||..  ....|   |||..|.. . |.| |.||.. .| |  .|.||. |...| .|..  .|        | |||.|||| |||
.....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGLVIATDINMQRLeeshTVDIPHTVSSIRQDRGQ-AILNIDQYAFIYRTLYEF
|||..|| .. ...|    .||. ..|  .|. |.. |. . .|| |.|. |.|.
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 695-932 1.5e-38 127.6 In-house 46-274 (281) alignment
Range on Protein: 695-932
Range on HMM: 46-274/281.0
RSPVIQSPERTRVPIPPTSPTSpsipskPSDfFLDASFIRGYDSShCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGgp
|   | . . ||| . |.. ..       .| ...|.|. ||..    || .     .| .|||. ||||. ..|| .    | ||. | .||| ..   
rYsnivaYDatrvkvtpneenk......ntD.Yinanfvpgykge.keyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns..

gTQLYGNILVTLKGGASGEHYFTSTLLIrNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESY-GPVVVHCSDGVGRTGLVIATDINMQ
 .  ||.. |. .  .. ..| . .. . . |..  | |..  . .| |  .|.....|..   .|.......   |.|.||| ||||||  || |  ..
.elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvk

RLEES-HTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYE
..|.. ...|.  .| ..|..|   .  . ||.|.|... .
aveaeleeldvkavvaelrkernlmvqtvvqyefvykavld

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 705-937 9.3e-49 160.8 In-house 35-267 (270) alignment
Range on Protein: 705-937
Range on HMM: 35-267/270.0
TRVPIpptsptsPSIPSKPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGPGTQLYGNILV
||| .       ... ...   .. | ..||.|.....|| |      . ..|||..||.....|| .    | |.  | .|||.. .   .  .|.| |
tRvrl.......eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikv

TLKGGASGEHYFTSTLLIRnvEKSLCRPVTHYWFSNWLDSEIPSSPQ------ALMSMLLQVHNTHQES--YGPVVVHCSDGVGRTGLVIATDINMQRLE
.    .  | | .  | ..  ||.  | ..|.|. .| |  .|....       |..|| .|.....|    .|..||||.||||||..||.|| .. ||
lalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLe

ESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKFL
|.. ||. . .. .|.|| . .   .||.|.|... |. ...
etkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 706-932 5.5e-31 102.6 In-house 63-276 (287) alignment
Range on Protein: 706-932
Range on HMM: 63-276/287.0
RVPIPptsptspsipSKPSDfFLDASFIRGYDSsHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGgpgtQLYGNILVT
||..            .  | ...|.|| || . .  .| |     .    ||. .....  .|| ||   |   .|| ||||...      ..|.  ..
rvllk..........gehpd.yinavfidgyke.kkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks....vvlGeynie

LKGGASGEHYFTSTLLIRNVEK-SLCRPVTHYWFSNWLDSE-IPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDI
|      ..|   .| ..| .| .  . |. | . || .   ...    |. .  .... .... ...||||||.|||... .| .. ... ..  ..|.
llneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDv

PHTVSSIRQDRGQAILNIDQYAFIYRTLYE
   . | |. . ...  ..|| ||.  . |
fqvlksqriqkpgsvqtveqykfindivle

0044763 (Phosphotyrosine protein) phosphatases II 710-929 6.1e-27 89.8 In-house 3-166 (178) alignment
Range on Protein: 710-929
Range on HMM: 3-166/178.0
PPTSPTSPSIPSKPSDFFLDASFIRGYdsshcSYIGATVSggdssTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGgpgtqlygnilvtlkgg
..|    ....  .. ....||.| ..      |.|.  .      .... ..|.  ..||.|....|||   |..|||...|                 
drtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

asgehyftstllirnvekslcrpvTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRleeshTVDIPHTVSS
                         .| . .. |.  |.... .. ..  ... ..|. |||.|||| ||||.|...| .. ...      ..... .. 
........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

IRQDRGqAILNIDQYAFIYRT
.|. |  .. | .|. ..|. 
vrerRp.ivpnpgqlrqLyef

0049772 (Phosphotyrosine protein) phosphatases II 716-937 1.3e-20 69.8 In-house 64-283 (314) alignment
Range on Protein: 716-937
Range on HMM: 64-283/314.0
SPSIPSKPSDfFLDASFIRGYdsshCSYIGATVSGGDSSTAF----------WRTV--WEQQSRTIVC---------------------LCSPYELGkvc
 |. | . || . .||...|.    ...| .          |          || |  .....|.||.                     |... ..|   
lpglpvsgsd.yinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...

pqywptkeggpgT----------QlygnilvtlkggasgehyftstllirNVE---KSLCRPVTHYWFSNWLDSEIPsSPQALMSMLLQVHNThqESYGP
                       .                          ..    . . |.. .|.  .. | . | ... . ..|  ...   .  ||
............neptaadlellk..........................eelydpelferlgikylripvpDgsap.lledfdeflefieea..dkggp

VVVHCSDGVGRTG--LVIATDINMQrleeshTVDIPHTVSSIRQDRG-----QAILNIDQYAFIYRTLYEFSKFL
|.|||..|.||||  .|.|  .  .       |..  ... .|. |       .| . .|| ||.. |.|. |||
vlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl

subfamily_PTPRK_pd Subfamily PTPRK 718-932 5.1e-36 119.1 In-house 64-275 (314) alignment
Range on Protein: 718-932
Range on HMM: 64-275/314.0
SIPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKeggpgTQLYGNILVTLKGGASGEHYFT
.|   ||  ...|..| .|  ..  .| .     .  . ||| |..... .|| |    | |.| | .||| .     |. ||.| |.|      . . .
tidgdpssdyinaalidsykrpa.afivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed.....tevygdikvelvetellaelvv

STLLIRNVEK--SLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRG
 .. ......  .  | | .. | .| | ..| | ..|.... .|.....|. |..||||| | ||||  || || .. .|. ..||. ..| ..|. . 
rifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkv

QAILNIDQYAFIYRTLYE
  .   .|| |||  . |
nmveteeqykfiydvile

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 718-936 9.1e-33 108.3 In-house 69-281 (439) alignment
Range on Protein: 718-936
Range on HMM: 69-281/439.0
SIPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKvcpqYWPTKEggpgTQLYGNILVTLKGGASGEHYFTS
 ||  |   ...| .|.||   .  || . .   ...  ||| |.|... ||| |.   |  |    |||...       ||.| |         .|   
eipgvphshyinanyikGyyddk.lyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsda....evcygdiavrvdrnielpnyvir

TLLIRNVE--KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNT-HQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRG
 . . |        | | .. .  | | ..|.    .. .|  .  .  .| ||||||||| |||||| .|| || ...|     |||   |. .|..| 
gfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrk

QAILNIDQYAFIYRTLYEFSKF
| . .. || ||| .. |  ..
qmvqalcqyvfiynavledivy

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 719-932 3.3e-37 122.8 In-house 65-274 (515) alignment
Range on Protein: 719-932
Range on HMM: 65-274/515.0
IPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTS
|  .|   ...||.|...|. . .|| .      |   ||| |....  ||. .    |  |. | .||| | |   .  .|.| | |    .       
indnPhsdyfnasyipsfdndk.ayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd..svkfGsikvelvsleactggikr

TLLIRNVEKslCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAI
.| .   ..  .| || . | .| |  .|   ..|. .. .|   |..   |...||| ||||||.||. |  . . .....||. ..|  |||.| . .
kltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylv

LNIDQYAFIYRTLYE
   .|||||| .. |
qtqeqyafiygavle

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 719-933 2.3e-36 120.2 In-house 66-276 (315) alignment
Range on Protein: 719-933
Range on HMM: 66-276/315.0
IPSKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTS
|  .| . ...||.|...|. . .|| .      |   ||| |....  ||| .    |  |  | |||| ...   .  .|.| |.|    .     . 
iddsPdsdyinasyiksvdddk.ayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad..svefGsikvellsleadtdgvar

TLLIRNVEKSlcRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAI
 | .|. |.|  | || . | .| |  ..    .|. .. .|   ...   ...|||| ||||||.||. |  .........||. ..|  .|..| . .
klvtrksees..rtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylv

LNIDQYAFIYRTLYEF
   ..||||| .. | 
qteeeyafiydavled

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 719-933 1.4e-34 114.6 In-house 73-283 (297) alignment
Range on Protein: 719-933
Range on HMM: 73-283/297.0
IPSKPSDFFLDASFIRGYDSshcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKVCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTST
. ..|.  ...|||..|.      .|  .    ..   ||. |...|  ||| |    |  | | .||. |    |.. .|.. |.|.  .. | .   .
vnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk....gvttfGdvsvvllsvsereGfikre

LLIRNVEKSLCRPVTHYWFSNWLDSEIPS--SPQALMSMLLQVHNTHQES-YGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQ
| ... .    | |  | | .| | ...   | ..|. .. .|......   ||..|||. ||||||.... |  . . .. ..|||  .|. .||.| .
levtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpy

AILNIDQYAFIYRTLYEF
 .   .||.|.| .. |.
lvqtkeqykfvyvavlea

subfamily_PTPN9_pd Subfamily PTPN9 721-935 5.8e-41 135.5 In-house 67-291 (297) alignment
Range on Protein: 721-935
Range on HMM: 67-291/297.0
SKPSDfFLDASFIRGYDSsHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTL
 . || ...|.|. ||   . ..|..  .    .. ||| ||||. ..||      | |.. | ||||..|.   .. .|.. |.     . |.| ...|
deasd.yinanfvdGykq.kkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees..saefgdlsvsnveveeeedykvrvl

LIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTH-------------QESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTV
 |.||...  | |||. |  | |  .||| ..|. .| .| ..              . |  |.||||| |.||||  |. ||...||||  |||. .||
eiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetv

SSIRQDRGQAILNIDQYAFIYRTLYEFSK
. .|. |  .|   .||.| | .. |...
kllrtqrafsiqtpeqyefcylavleyal

subfamily_CG7180_pd Subfamily CG7180 721-933 1.2e-32 107.8 In-house 66-289 (296) alignment
Range on Protein: 721-933
Range on HMM: 66-289/296.0
SKPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKVCPQYWPTKEggpgTQLYGNILVTLKGGASGEHYFTSTLL
 . .. ...|... ..   .  ||       ..  .||| |..... ..| |. . .  | .|.||| |      . ||.|.| .    .  .  . |. 
GeeksdYinavyvdsflkkk.eyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks....keqygeifveiveekqyanlkirtfk

IRNV----------EKSLCRPVTHYWFSNWLD-SEIPSSPQALMSMLLQVHNTHQ-----ESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPH
.             .|   | |... .  |    ..|.| .||. .. .|.   .     . .|||||..|||..|.|  .| |.|.. .|. . ||. .
ltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFe

TVSSIRQDRGQAILNIDQYAFIYRTLYEF
 |  .|..| | . |...| .|| .| |.
avktlrrsRpqLvenveeYkyiYdvllea

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 722-934 1.7e-48 160.3 In-house 72-280 (318) alignment
Range on Protein: 722-934
Range on HMM: 72-280/318.0
KPSDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLL
. || ...|..| || ... .|| |     .  . ||| ||||.|..|| |    | ||. . .||| |    |.. ||.. |.||   . ..|   .. 
egsD.yinanyidGyrrkk.ayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk....gsrsygklvvelkeevelsdyvlrefk

IRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTH-QESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILN
... |..  | |  | . .| |. .|.|.  |.... ||.... ....||.||||| ||||||  || || ..|...  .||. .||. .|. |   .  
vtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt

IDQYAFIYRTLYEFS
 ||| ||| .| |. 
edqyefiydvlleal

subfamily_PTPRB_pd Subfamily PTPRB 722-933 3.6e-45 149.2 In-house 76-284 (293) alignment
Range on Protein: 722-933
Range on HMM: 76-284/293.0
KPSDFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGgpgTQLYGNILVTLKGGASGEHYFTSTLL
.... ...|..|.|| | .  .| .     ..   ||| |||..|..|| |    | ||| | .|||..|    ..|||.| |||.   . |.. . .|.
esgsDYinanyipgynspr.efiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee...pvlyGdikvtlvaeeeledwvirelk

IRNveKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTH--QESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAIL
|..  .. .| |..| |  | | ..|.....|.... .|....  ..| .|.||||| ||||||  || |  .|..||. .|||  .|...|..| . . 
iek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvq

NIDQYAFIYRTLYEF
. .|| ||.... ..
tekqYifihqcvldl

subfamily_PTPRN_pd Subfamily PTPRN 722-930 2.8e-33 109.9 In-house 81-288 (297) alignment
Range on Protein: 722-930
Range on HMM: 81-288/297.0
KPSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTkEggpGTQLYGNILVTLKG-GASGEHYFTSTL
. ......||.|   |  . .|| .     .. ..||..|||| .  || |..  | | | | .|||  |   |...|.   | |       . |.  ..
aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd.e...Gsevyhiyevhlvsehiwcddylvrsf

LIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEE-SHTVDIPHTVSSIRQDRGQAIL
 ..|...|  | || . |  | ....|.|...|. .  .|  ...    |.|||||||.||||  |. |. ..||    . .||  |.  .|..| . . 
ylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvk

NIDQYAFIYRTL
  ||. |.. ..
tkdqfefaltav

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 722-931 2.3e-31 103.7 In-house 55-263 (283) alignment
Range on Protein: 722-931
Range on HMM: 55-263/283.0
KPSdFFLDASFIR--GYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYE-LGKVCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTST
..   ...|.||     .     || |     .    ||. |....  .|| |    | | . | |||| .    |.. ||.  |||.   . . .    
esr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr....GsedyGeftvtlrkettsnsfiike

LLIRNV---EKSLCrpVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQ
||.|.    ...|   ..|| . .||. .  .   .|. . . . .  ..  ||.||||| |.|||.  ||    .. .  .  ||.. .|  .|..|  
lllrvnssakstll..lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmm

AILNIDQYAFIYRTLY
|. . ||| ...    
avqtldqyklvhelvl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 722-933 2.5e-28 94.2 In-house 73-287 (325) alignment
Range on Protein: 722-933
Range on HMM: 73-287/325.0
KPSDFFLDASFIRGYdSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKVCPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLI
.||  ...||..| .      .. | .   ..   .|| | . ..  .| |    .  . | .||| . |   .. .| . | |.       |    | .
dpssdyinasylrdd.kkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgk..sktfGglevklrtieeisdyvhrvldv

RNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQ------ESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQ
..|.|   | |  . .  | |   .  | .|.|.|  |.. ..      .. .|..||||.||||||  |.    .... |   |||   |  .|.|| .
kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrps

AILNIDQYAFIYRTLYEF
 .  .||| .|| .| |.
mvetvdqyiliyealvea

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 723-930 2.2e-30 100.6 In-house 33-236 (239) alignment
Range on Protein: 723-930
Range on HMM: 33-236/239.0
PSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYEL-GKVCPQYWPTKeggpgTQLYGNILVTLKGGASGEHYFTSTLLI
|   ...||..| || |  .|| .  .   ||  ||| .|...   || |    |   | | ||||       |  | |. |||.       |   |...
phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.....tskycnlrvtlrktevfadyiirtfvm

RNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNID
 .| ..  | | .| |. | |  .|    |.. .  .. .       | |.||| |||||| ..  |  ... .. .||||   | .||.|| . .   .
sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtse

QYAFIYRTL
|| ||. ..
qyvfihlav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 723-930 2.6e-30 100.4 In-house 34-237 (239) alignment
Range on Protein: 723-930
Range on HMM: 34-237/239.0
PSDFFLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYEL-GKVCPQYWPTKeggpgTQLYGNILVTLKGGASGEHYFTSTLLI
|   ...||..| || |  .|| .  .   ||  ||| .|...   || |    |   | | ||||       |  | |. |||.       |   |...
phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.....tskycnlrvtlrktevfadyiirtfvm

RNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNID
 .| ..  | | .| |. | |  .|    |.. .  .. .       | |.||| |||||| ..  |  ... .. .||||   | .||.|| . .   .
sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtse

QYAFIYRTL
|| ||. ..
qyvfihlav

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 724-933 1.2e-42 140.9 In-house 37-241 (250) alignment
Range on Protein: 724-933
Range on HMM: 37-241/250.0
SDfFLDASFIRGYDSShCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKVCPQYWPTKEggpgTQLYGNILVTLKGGASGEHYFTSTLLIRN
|| ...|||. ||| .  ..| .     ..   ||| |.|..| ||| | .  | .|...||||...    .. ||...|.|.       | . .| . .
sd.yinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek....aekyGdvtvsllskeefadytkrklklsk

VEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQE-SYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQ
 .|.  | | .. | .| |  .|   .| . .| .|. ..|.   .||.|.|| ||||.|  || |  ..||.....||. . .  .|.|| .|.   .|
akkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleq

YAFIYRTLYEF
| |.|. . ..
yvfvyeiilka

subfamily_PTPN12_pd Subfamily PTPN12 724-933 9.1e-38 124.8 In-house 67-276 (290) alignment
Range on Protein: 724-933
Range on HMM: 67-276/290.0
SDFFLDASFIRGYDSsHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGgpGTQLYGNILVTLKGGAS-GEHYFTSTLLI
 . ...|.||.| .. ...|| |     .  . ||| .||.. . .| .|  .||||  | .||| . .   .  .|.. |||.      . ..  || .
gsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege..eelefgefevtleeekavdddflirtLkv

RNVekSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT---VDIPHTVSSIRQDRGQAIL
..   . .| |. . . .| | ..|||.. |.... .|.......  |.||||| |||||| .|| |.  . |.. ..   .|. . | ..|..|  .. 
eaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvq

NIDQYAFIYRTLYEF
  .|| ..|... |.
tkeqyelvykavael

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 724-936 1.4e-36 121.5 In-house 89-293 (319) alignment
Range on Protein: 724-936
Range on HMM: 89-293/319.0
SDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCspyelGKVCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRN
|| ...|||. || .    || |     ..   ||| .||... ||| |       . | |||| |    . . ...  | ..     . |    . . .
sd.yinasfvtGyqrkd.kyiaaqGPldntladfWrmiweyncstivllt.....kdkcsqywplk....ivikeerfkvkvdsveetaeyvvrdielse

-VEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQES--YGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNI
  ..   | .| . |  | |   | .|  || .. .|.  ..      ..||||| ||||||  |. |. ..|..| . ||. ..|  .||.| . . ..
dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

DQYAFIYRTLYEFSKF
 || ||| .| |   |
vqykfiysalleehlf

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 724-936 2.7e-36 120.5 In-house 53-257 (284) alignment
Range on Protein: 724-936
Range on HMM: 53-257/284.0
SDfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCspyelGKVCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRN
|| ...|||| || . .  || .     ..   ||| .||... ||| |       . | |||| |    . . ...  | ..     | |    . . .
sd.yinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplk....ivikeerfkvkvdsveeseeyvvrdielse

-VEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQES--YGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNI
  ..   | .. . |  | |   | .|  || .. .|.  ..      ..||||| ||||||  |. |. ..|..| . ||. ..|  .||.| . . ..
dgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

DQYAFIYRTLYEFSKF
 || ||| .| |   |
vqykfiysalleehlf

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 725-933 2.3e-47 156.5 In-house 75-278 (288) alignment
Range on Protein: 725-933
Range on HMM: 75-278/288.0
DFFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGgpgTQLYGNILVTLKGGASGEHYFTSTLLIRn
  ...||.| |.....  || .     |.   ||. |.|... ||| | .  | ||  | .|||...     ..||.. |||..    |.. . .||.  
aDYinasyidgekkkk.kyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadk...pknyGsvtvtlveskeledfvlrkllle.

vEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQY
  |   . .|.| .  | | ..| | . |. .| ||....|.  ||..||||.||||||  || |  ....||. ..|.  ||. .|. | . . .  ||
.kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqY

AFIYRTLYEF
 |||..| . 
efiyevllsl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 725-935 6.7e-19 62.9 In-house 58-260 (267) alignment
Range on Protein: 725-935
Range on HMM: 58-260/267.0
DfFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWrTVWEQQSRTIVCLCSPYELGKVcPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLIRNV
. ...||.. ||   .  .|    .   . | |. ||. .|  ... |  .   ... ...|| | |   .. | .. |        . |   || ..  
e.yinasyvegyktkn.afivtqdplkntitdfl.tvihdqkvpvivlltkvftdni.rlfwPPkmgq..akkyqdltvehslekeendyqiitlelkfk

EKSlCRPVTHYWFSNWlDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYA
..| .. || |.. .| . .    |     . .  .|  ..   |.||.|||||||.|  .  |  ..|. .  ..|| . .  ||. |   .   ..| 
nes.ahnvtlyyykkw.nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryi

FIYRTLYEFSK
.|...| |...
yihellaeyae

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 726-932 4.4e-35 116.0 In-house 77-281 (290) alignment
Range on Protein: 726-932
Range on HMM: 77-281/290.0
FFLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNV
 ...|..| ||  .. .|| .     .    ||. .|....  || |..  | || .| ||||..    .|. ||.. ..|    . ..| . .| ..| 
eyinAcyikgykekk.qyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds....dtkaygefsikllneetlneyierklevknk

EK-SLCRPVTHYWFSNWLDSE-IPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQ
..   .. ||.| ..|| . . ..     |...  .... ...  ...||||||.|||... .|... ... .    .|. . . | |. . . .   .|
nsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqq

YAFIYRTLYE
| .|.. . .
yqgifqivlt

subfamily_PTPRD_pd Subfamily PTPRD 727-937 1.5e-57 190.5 In-house 78-284 (564) alignment
Range on Protein: 727-937
Range on HMM: 78-284/564.0
FLDASFIRGYDsSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKegGpgTQLYGNILVTLKGGASGEHYFTSTLLIRNVE
.  |||| ||. .. .|| .     ..   ||| ||||.|.||| | .  | ||  | .|||.|  |  |. ||.. |||.     ..|   |. ... .
YINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek..g..tetygeltVtleeeeeladyeirtfklkkkk

KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAF
.|  | |... | .| |. .| |...|.... .|......  ||.||||| ||||||  |. |. ..|..|..||||  .|. .|..|   . . .||.|
ssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiF

IYRTLYEFSKFL
|.....|. .. 
iheailealacg

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 727-933 6.4e-42 138.8 In-house 86-289 (298) alignment
Range on Protein: 727-933
Range on HMM: 86-289/298.0
FLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKeggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVE
.. |||. .|. .. ..| .      . . ||| |.|... ||| | .  ||.|  ...|||..    |.. ||.| |.|.   .   . . .| . . .
YiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde....gketygeitvsllskeefadlivrklkvskkk

KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNtHQESYG--PVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQY
..  | | .  |..| |  .|.  .... .| .|.  .|.  |  ||.|.||.||||.|  || |  ..|......||. ..|  .|..| .|.   .||
eekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqY

AFIYRTLYEF
.|||    |.
vfiyeavlea

subfamily_PTPN13_pd Subfamily PTPN13 727-932 2.8e-36 120.2 In-house 62-267 (273) alignment
Range on Protein: 727-932
Range on HMM: 62-267/273.0
FLDASFIRG-YDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPgTQLYGNILVTLKGGASGEHYFTSTLLIRNV
...||.|.   .  . .|| .     .. . ||. ||||... |. . .  | ||| | .||| ... . ..... . |.| .    . .  ..| ....
yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk.lkvsnrlevellkvqkldgfvvralavkds

EKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQeSYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYA
| .  | |.|  | .| | ..|||.. |. .. .| . .. . ||.||||| |.||.| .|. |. .. .|  . .|. ..| ..|. |   .   ||| 
esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyi

FIYRTLYE
|.|... |
fvykaile

subfamily_PTPN14_pd Subfamily PTPN14 727-933 2.2e-35 117.1 In-house 78-295 (300) alignment
Range on Protein: 727-933
Range on HMM: 78-295/300.0
FLDASFIRG-YDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTQLYGNILVTLKGGASGEHYFTSTLLIRNV
...|| |.    ... ||| |        . ||. ||||. . || | .  | ||  . .|.| .|    |  .|.  || |   . . . |..| .. .
yinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl

EKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTH---------QESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQ
  .  | | |  . .| | ..|. ..  .| | .|.            .||  ||.||||.|||||| .| .|. .. ||  ...||..... .|. |  
pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrml

AILNIDQYAFIYRTLYEF
 . .. || |.|..| ..
lvqtlaqYkfvYkvliky

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 727-932 3.9e-30 99.8 In-house 31-237 (237) alignment
Range on Protein: 727-932
Range on HMM: 31-237/237.0
FLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGgPgtQLYGNILVTLKGGASGEHYFTSTLLI-RNV
...|....|.| .  .|| |      |   ||. ||...   || |    |  .  | .|||  .  |  . || . |.||       |   .||. ...
yinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.p..aaygvltvslkkkeefsdytvrslllskrl

EKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNT--HQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQ
..   | .  | |. | |  .|    ||. .  .. |   |    || ..||| ||||||...  |  ... .| . |||   | || .||   |   ||
tlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdq

YAFIYRTLYE
| ||..|. |
yvfihqtile

0043147 (Phosphotyrosine protein) phosphatases II 727-927 1.8e-27 91.5 In-house 7-154 (172) alignment
Range on Protein: 727-927
Range on HMM: 7-154/172.0
FLDASFIRGYDsSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPyelgkvcpqywptkeggpgtqlygnilvtlkggasgehyftstlliRNVEK
. .||.. .|    ...|     ..     ||| ..|.. ..||.|..                                                .  .
yinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydpe

SLCRPVTHYWFSNWLDSEIPsSPQALMSMLLQVHN-THQESYGPVVVHCSDGVGRTGLVIATDINMqrleesHTVDIPHTVSSIRQDRGQAILNIDQYAF
 |.| . .|.. .| |   | ... |...| ....  .... |||.|||| ||||||...| .. .      . ... ..|. .|. |..|. | .|| |
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IY
.|
ly

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 727-933 1.2e-23 78.3 In-house 72-292 (301) alignment
Range on Protein: 727-933
Range on HMM: 72-292/301.0
FLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGpgTQLYGNILVTLKGG-----------------
...||.| || ...  .| |        . ||| .|...  .|| ..   |  |  | ||||. |    .. .|.. |||.                   
yinasyidgysekk.kfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae..seefgpftvtlvneqvyPdfvirqlnvkiqd

ASGEHYFTSTLLIRNVEksLCRPVTHYWFSNWLDSEI-PSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVS
.|.. |. ... ...      . |. .   .| .  . .     |...  ..| ... . |||||||||.|.|.|  .. .| .        ||.   . 
gsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtk

SIRQDRGQAILNIDQYAFIYRTLYEF
..|. .  |.  ..|| .||  . ..
avrrskpgaVtTLeqytsiydvidmy

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 727-933 1.4e-21 71.5 In-house 67-276 (287) alignment
Range on Protein: 727-933
Range on HMM: 67-276/287.0
FLDASFIRGYDSSHcSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKeGGPgTQLYGNILVTLKGGASGEHYFTSTLLIRNVE
...| .. .|   . ..| |      .   ||| |.|..| ... .    | ..  | .||| .   |  .. |  .| |.      .| . .| . ..|
yinanyvasytdde.afiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evP.mrvGGysvvlldydikePeygvralrlidle

KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQV--H---NTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNI
   .| |  . . .| |  .. .  .|. . |.|  |   .   .  ||.|||.. |.||.|...|| . ..|||.   ||.  .|  .|. |   .  .
trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

DQYAFIYRTLYEF
 |. ..| .|  .
vqlrllyealvty

subfamily_ptpA1_pd Subfamily ptpA1 727-896 1.4e-15 52.0 In-house 77-258 (418) alignment
Range on Protein: 727-896
Range on HMM: 77-258/418.0
FLDASFIRGYDSshCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTQLYGNILVtLKGGASGEHY-----FTSTLL
...| .| |       .| .     .. . ||| |||.. | || |    |  .. | .||| . ||    .|||    . |  | |           ..
yinanyidgayp..kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngne.vfgtysvelveviqdpereii

IRNVE---KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQ------ESYGPVVVHCSDGVGRTGLVIATDINMQRLEE
 ||.    .   | .|.| .  | | .||   | .  .|  . | ..      .   |..|||| |||||| . .. | |..|. 
trnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldh

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 727-933 2.8e-14 47.7 In-house 61-269 (285) alignment
Range on Protein: 727-933
Range on HMM: 61-269/285.0
FLDASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGGPGT-QLYGNILVTLKGGASGEHYFtSTLLIRNV
.. ||..|     . .|| .     .. . ||. .....   .. ||. .| | . |  |.| | |       |   |   |  |     .  .| . | 
yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtil.naltvint

EKSLCRPV--THYWFSNWLDSEIPSSPQALMSMLLQVHNTHQeSYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQ
| .   |.   |     | |   |   . .. .   |..       |..|||| |||||  ..  |    |. |   ...   |  .|  | ||. .  |
edasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmq

YAFIYRTLYEF
. |.|  | |.
flflyvvlmey

0051082 (Phosphotyrosine protein) phosphatases II 728-932 4e-27 90.1 In-house 6-151 (151) alignment
Range on Protein: 728-932
Range on HMM: 6-151/151.0
LDASFIRGYdsshcSYIGATVsggdsSTAFWRTVWEQQSRTIVCLCSPYELGkVCPQYWPTKEggpgtqlygnilvtlkggasgehyftstllirnveks
...|.. |.      |...       . .|.....|.. .|||.|.|..| |  ||.|.|  .                                     
infsyvtgg.....lyrsggp.....ladflellkelgiktivnlrseeerg.ycpeylpelg.....................................

lcRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNthqESYGPVVVHCSDGVGRTGLVIATDINMQRleeshtVDIPHTVSSIRQDRGQAILNIDQYAFIY
  . |.|... .| |  .| |..|....| .. .    . |||.|||| |.||||...| .. ...      |..  ... .|. |. ..   .|. |..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

RTLYE
. |.|
falle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 728-933 1.2e-24 81.5 In-house 84-282 (290) alignment
Range on Protein: 728-933
Range on HMM: 84-282/290.0
LDASFIRGYDSSHCSYIGATvsgGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTqlYGNILVTLKG-GASGEHYFTSTLLIRNVE
. | ...| ..      ||.    |.   .|| | ...  .|| ||   | ||  | ||.| |||   |  .|.| |.        ..    || .|...
vhanyvkGlkamfiltqGal...kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt..fGeitvlcseeddkdaniikktlsvrdkd

KSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNthqeSYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAF
.     . |.    | |  .. |  ||. .|  . .      |||||||| |.||||  .| .. .| | . . .|.  .| ..|. | ...    ||  
sGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyla

IYRTLYEF
. . | ..
lveilldl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 729-933 4.2e-21 69.9 In-house 84-288 (305) alignment
Range on Protein: 729-933
Range on HMM: 84-288/305.0
DASFIRGYDSSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEK-
 | ..      .  .| |     ..   ||  | ...   || ||   ||||. | ||||.  |   .   | ..  . |    |      . . |.   
hanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltys

-SLCRPVTHYWFSNWLDSEIPssPQALMSmlLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT-VDIPHTVSSIRQDRGQAILNIDQYA
 .    | |  ...| |  .|  |  | |  |..  . . |  |.||||| |.|||| ..| .  .... | .    .|. | ..|..|  .| |  || 
gdqkmsvrhlqwtewpdrgvp..pcklts..lellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqyl

FIYRTLYEF
||.| . ..
fihrvmlny

0036282 (Phosphotyrosine protein) phosphatases II 730-928 5.4e-33 109.5 In-house 7-164 (174) alignment
Range on Protein: 730-928
Range on HMM: 7-164/174.0
ASFIRGYDSSHCSYIGATVSGgdsstaFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTkeggpgtqlygnilvtlkggasgehyftstllirnVEKSL
||.. ..  .   ..|.          ||. ..|....|.|.|....|||   |..|||.                                     ..|
aspldlsyitprliagqgpla......fwemlkelgittvvmlleekelglykcinywpe...................................lredl

CRPVTHYWFSNWLDSEIPSSPQaLMSMLLQVHNTHQE-SYGPVVVHCSDGVGRTGLVIATDINMQRLEeSHTVDIPHTVSSIRQDRGQAILNIDQYAFIY
 | . .|.. .| | . |.... | ... .|.. ..| . |||.|||| ||||||...| .. ...|. . .||. ..| ..|. |.... . .|| |.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

R
 
y

0041856 (Phosphotyrosine protein) phosphatases II 730-935 6.5e-30 99.5 In-house 24-172 (182) alignment
Range on Protein: 730-935
Range on HMM: 24-172/182.0
ASFIRGYDSSHCsYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCspyelgkvCPQYWPtkeggpgtqlygnilvtlkggasgehyftstllirnveKSLC
|....|.  .   .| . .   ..  .|.|...|.. .|||.|.        ...|||                                      . | 
anlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt........eelywp......................................elle

RPVTHYWFSNWLDSEIPSsPQALMSMLLQVHNthqeSYGPVVVHCSDGVGRTGLVIATDINMQRleeshTVDIPHTVSSIRQDRGQAILNIDQYAFIYRT
| ...|.. .| | ..|. .. | ... .|..    . |||.|||| |||||| ..| .. ...      |.....|. .|. | ... . .|| |... 
rlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqla

LYEFSK
|.|. .
llelll

subfamily_PTPN1_pd Subfamily PTPN1 738-939 1.4e-30 101.0 In-house 68-276 (290) alignment
Range on Protein: 738-939
Range on HMM: 68-276/290.0
SSHCSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTQLY-GNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHY
  . ||| .     .  . ||. ||||.|...| |    | ... | ||||..|     .|   .. |.|    . ..|  ..| . |..   .| ..|.
eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhf

WFSNWLDSEIPSSPQALMSMLLQVHNTH--QESYGPVVVHCSDGVGRTGLVIATDINM---QRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTL
 .  | |  .|.||.|....| .| ..   .. .||.|.||| |.||.| ..  |  .   .. ..  .||| ...  .|. |   |   ||  | | ..
hyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai

YEFSKFLSS
 | .|.. .
leGakvikg

0051429 (Phosphotyrosine protein) phosphatases II 741-936 6.7e-33 109.9 In-house 9-227 (272) alignment
Range on Protein: 741-936
Range on HMM: 9-227/272.0
CSYIGAT-------------VSGGDSSTAFWRTvWEQQSRTIVCLCSPYELGKVC-PQYWP--------TKEGGPGTQLYGNILVTLKGGASGEHYFTST
 ...|                    .   |||  .|.. .|||.|.|..|.|..  ..|||        . . .. | |||.. |||      ..|   .
ardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilre

LLIRNV-EKSLCRPVTHYWFSNWLDSEIPSSPqaLMSMLLQVHNthqesYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVD--------IPHTVSSI
||....   .  | |.|... .|.|  .|...  | ..| ....      |||.|||| |..|||.|.| .. .......  ||        . ..|. .
llltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

RQDRGQAILNIDQYAFIYRTLYEFSKF
|. | .|. . .||.|.|. | |. . 
raqrpgavqteeqylflyeallellrs

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 741-855 3.5e-07 24.4 In-house 76-189 (297) alignment
Range on Protein: 741-855
Range on HMM: 76-189/297.0
CSYIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGpgTQLYGNILVTLKGGASGEhYFTSTL-LIRNVEKSLCRPVTHYWFS
  || |     ..   ||. |.||. |.|| ..   | |.  |  |||  ...   .  |...|      | | . .  |  .. . .|  | |.|  | 
lkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe..rlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqfl

NWLDSEIPSSPQALMSM
.| |  .||  . |  .
swpdhGvpsdledlvrf

subfamily_PTPN3_pd Subfamily PTPN3 743-930 2.1e-36 120.3 In-house 86-271 (280) alignment
Range on Protein: 743-930
Range on HMM: 86-271/280.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEggpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWL
|| .     ...| ||. ||||.|..|| | .  | |.| | ||||..|    .. ||.. |...  .. . | .  |.... |..  |....  . .| 
yiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPete...deleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWp

DSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTL
|...|.... ..... .|..... .  ||||||| |.||||..|. .. .. .|... | ... |. .|. |.  . . .|| |.  ..
dhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai

0046846 (Phosphotyrosine protein) phosphatases II 743-933 2.1e-30 101.2 In-house 14-172 (176) alignment
Range on Protein: 743-933
Range on HMM: 14-172/176.0
YIGATVSGGD-----------SSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGtqlygnilvtlkggasgehyftstllirnvekslcr
|| | .  |.           .  .|.. ..|.. ...|.|....|||.. ||.|||  |.                                       
yinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................................

pvtHYWFSNWLDSEIPSSpQALMSMLLQVHNTHQESyGPVVVHCSDGVGRTGLVIATDinmqRLEESHTVDIPHTVSSIRQDRG-QAILNIDQYAFIYRT
   .|.. .| |  .|.. ..|...| ....  .|  |||.|||| |.||||...| .     || .. ... .... .|. |  .|. . .|| |.|. 
...qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyef

LYEF
....
elll

0049260 (Phosphotyrosine protein) phosphatases II 743-927 5.2e-29 96.3 In-house 11-143 (152) alignment
Range on Protein: 743-927
Range on HMM: 11-143/152.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWptkeggpgtqlygnilvtlkggasgehyftstllirnvekslcrpvtHYWFSNWL
.|..   |. .   ||| ..|.. .|||.|....||||. |.||.                                               .| . .| 
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlpwp

DSEIPSSPQALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMqrleesHTVDIPHTVSSIRQDRGQAILNIDQYAFIY
|.  |...| |. .|| ..   ... |||.|||| ||||||...| .. .      . |.. ..|. .|. | .|. | .|. |.|
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 743-928 1.1e-22 75.2 In-house 7-198 (199) alignment
Range on Protein: 743-928
Range on HMM: 7-198/199.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLIRNVE--KSLCRPVTHYWFSN
|| .  .  .. . ||. |||  |  || .       .   | |||| | |  |  ||.. || |  ..   |  ..|.. |        | ..|| |. 
yiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesg..tgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WLDSEIPSSPQALMSML--LQV-HNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT--VDIPHTVSSIRQDRGQAILNIDQYAFIYR
| .   |     .  ..   .| ..  ||   ||.|||||| | ||. .| || ..  |||.|  ||.      .|| |   |  ...| |||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 743-928 1.1e-22 75.2 In-house 6-197 (198) alignment
Range on Protein: 743-928
Range on HMM: 6-197/198.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLIRNVE--KSLCRPVTHYWFSN
|| .  .  .. . ||. |||  |  || .       .   | |||| | |  |  ||.. || |  ..   |  ..|.. |        | ..|| |. 
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesg..tgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WLDSEIPSSPQALMSML--LQV-HNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHT--VDIPHTVSSIRQDRGQAILNIDQYAFIYR
| .   |     .  ..   .| ..  ||   ||.|||||| | ||. .| || ..  |||.|  ||.      .|| |   |  ...| |||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 743-933 5.2e-22 73.2 In-house 84-276 (307) alignment
Range on Protein: 743-933
Range on HMM: 84-276/307.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGGPGTqlYGNILVTLK---GG----ASGEHYFTSTLlIRNVEKSLCRPVTH
.| |     ..   ||  . ...  ... ||   ||.|. | |||| .||   .  .|.   |.     |    |  |..   |  .. .  . .| ..|
ficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklv..fgeapntisvanlgakklapdedlinvtt.lkvdwaqksrtiqh

YWFSNWLDSEIPSSPQALMSMLlQVHNTHQesyGPVVVHCSDGVGRTGLVIATDINMQRL-EESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
. ..|| |  .|    . . .| .  . ..    ||||||| ||||.| ..|  . .... .     |. . |  .|..|  || .  || ...| | |.
lqwenwpdrgvpqinltainll.eavrydt...npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley





subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 743-934 2.9e-18 60.7 In-house 90-287 (305) alignment
Range on Protein: 743-934
Range on HMM: 90-287/305.0
YIGATVSGGDSSTAFWRTVWEQQSRTIVCLCSPYELG-KVCPQYWPTKEGGPGTQLYGNILVTLKGGASGEHYF--------TSTLLIRNVEKSLCRPVT
.| .     .. . ||   ....  .|  ||   | | | | .|...|..   .   ..  ...|  .|..  |        | | |. .   .  | ||
fictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvt

HYWFSNWLDSEIPSSPQALMSMLLQVhnthQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVD-IPHTVSSIRQDRGQAILNIDQYAFIYRTLYE
|| . .| |  .|.. .|.. .| .     . | ||.||||| |.|||| |.  .  ...| . . ..   . .  ||..| ..|   .|| |... . .
hyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln

FS
. 
yf

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 751-949 3.2e-11 37.5 In-house 92-288 (312) alignment
Range on Protein: 751-949
Range on HMM: 92-288/312.0
GDSSTAFWRTVWEQQSRTIVCLCSPYELGK-VCPQYWPTKEGG---PGTQLYGNILVTLKGGASGEHYFTSTLLiRNVEKSLC--RPVTHYWFSNWLDSE
 ...| ||. .    | .|. ||.  | |   | .|     |       ..| .    .. |       |  .| . | |.      . || .. | |  
entcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvl.kvvvkatgqesklnhyqwaswpdhg

IPSSPQALMSMLLQVHNTHQesygPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFskfLSSSGTKE
.| | .. . .|  |.. ..    ||. ||| |||||| ..  .  .  |      .. ..   .|.|| ...  . || .  |.. ||   | | |  .
mpdscdtalrllsavkkdkk....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef...lyskglyk

TSDTE
 .. |
rneqe

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 753-935 3.3e-19 63.4 In-house 105-286 (302) alignment
Range on Protein: 753-935
Range on HMM: 105-286/302.0
SSTAFWRTVWEQQSRTIVCLCSPYELGKVCPQYWPTKEGGpgTQLYGNILVTLKGGA--SGEH-YFTSTLLIRNVEKSLCRPVTHywFSNWLDSEIPSSP
|   ||| |....  ..| |  . || |   ...|.| |    . ||.. |  .     ..|.  ..  .|  ..  |.   |..  ..|| ....| . 
sveeFWrmvfqekivsvvilvgeeelkktlselfpkksgd..ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyv..ltnWkqkkvpvky

QALMSMLLQVHNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
 .|.    .|.. ....  ..|.    |.|| | ...  . ...|.... . |  .| |||..| .|. ...||...|..|  . |
aeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyik

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 753-932 4.7e-16 53.4 In-house 102-280 (301) alignment
Range on Protein: 753-932
Range on HMM: 102-280/301.0
SSTAFWRTVWEQQSRTIVCLCSPYE-LGKVCPQYWPTKEGGPGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSL-CRPVTHYWFSNWLDSEIPSSPQ
.|  ||  .   .  .|| |.   | | ..| .| |.| .        .| .. |     ..    || ...  . .  | |||| .|.| | ..| |  
tsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksha

ALMSMLlqvhNTHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQY-AFIYRTLYE
 |. ..    .  ..|  |.|||||.|.||.   |.|..  ...|   |... ...  .|..| ... .  |       |.| 
elfdlm....elvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyr

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 755-933 5.7e-17 56.6 In-house 42-220 (255) alignment
Range on Protein: 755-933
Range on HMM: 42-220/255.0
TAFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGgpGTQLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALM
 .|..|.  ... ..| ||  .| |.. | .|.|..    . . . .. ||    ..     | ...    ||   . |.|| .  |..   |  .. ..
dkfyqtivqtktevvvmlcdfaeegvekcssyfplekd..eklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

SMLLQVHNthqeSyGPVVVHCSDGVGRTGLVIATDINMQ----RLEESHTVDIPH--TVSSIRQDRGQAILNIDQYAFIYRTLYEF
 .|  |..    |  .|||||| |.||.   . ...  |     |....||.. .   .  .|. | .|| .  | ||   .. ..
nilkvvrd....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 756-928 2e-17 58.3 In-house 82-253 (290) alignment
Range on Protein: 756-928
Range on HMM: 82-253/290.0
AFWRTVWEQQSRTIVCLCSPYELGK-----VCPQYWPTKEGGpgTQLYGNILVTLKGGASGEHYFTSTLLIRnVEKSLCRPVTHYWFSNWLDSEIPSSPQ
 || .. . ... .| ||   |  .      | .| |...|.     .... |  |     .   | .|...  ..     |||.....| ..... ...
kfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge..elkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtk

ALMSMLLQVHnthqESYGPVVVHCSDGVGRTGLVIATDINMQRLE-ESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYR
 |.|.. .|.     |  ||.||| ||. |   . | .. .| .   |. | .   ....|. | .|| .  ..||.  
tllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 756-932 2.1e-17 58.1 In-house 97-269 (288) alignment
Range on Protein: 756-932
Range on HMM: 97-269/288.0
AFWRTVWEQQSRTIVCLCSPYELGKVCP-QYWPTKEGgPGTQLYGNILVTLKGGASGEHYFTSTLlIRNVEKSLCR-PVTHYWFSNWLDSEIPSSPQALM
 .|. . |.. . || ||   |.||    .|.|.| |   ...  .  |. |  |  ..  . .| .|. ..   .  | .  . .| |  .| . .. .
elWkmllesdveyivmlcellekGkeksaeyfPsklG.ekarigrlctvvkkkradidklvkvsl.lriskegeekvivkilhlleWdddgvPenylspl

SMLLQVHNTHQesygPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYE
 .|  ......    |.|||.| |||||| .| . | .. |  .  . |.. ... |..| .||    || ...| ..|
rllevlkslqk....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvle

subfamily_hpo-7_pd Subfamily hpo-7 756-933 8e-14 46.2 In-house 49-226 (263) alignment
Range on Protein: 756-933
Range on HMM: 49-226/263.0
AFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKEGgpGTQLYGNILVTLKGGASgEHYFTSTLLIRNVE-KSLCRPVTHYWFSNWLDSEIPSSPQALM
.|..|.  ... ..| ||  .| |.. | .|.|..    . | . |. |.     | .    .  |. ... |   . |.|| .  |.. . |  ..  .
kfyqtivqtktevvvmLcDfneegvekcssyfPlekd..ekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelareil

SMLLQVhnthQESyGPVVVHCSDGVGRTGLVIATDINMQ----RLEESHTVDIPH--TVSSIRQDRGQAILNIDQYAFIYRTLYEF
 .|  .    ..|  ..||||| |.||.     ...  |     |....||.. .   .  .|. | .|| .  | ||   .. .|
nilkva....rns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 756-935 2.2e-13 44.5 In-house 109-291 (310) alignment
Range on Protein: 756-935
Range on HMM: 109-291/310.0
AFWRTVWEQQSRTIVCLCSPYELGKV-CPQYWPTKeGgpGTQLYGNILVTLKGGASGEHYF---TSTLLIRNVEKS-----L-CRPVTHYWFSNWLDSEI
 ||| ...... .|. ||   | |.  |  |||.  |   |. || | ||  . .| |      . |..  ||        |    |.   . || |  .
dfwrmifqeraesilllckvgeegrpkcvgywpsl.g..vtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgv

PSSPQALMSMLLQvhntHQESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSK
|      .   |      |  .||.||||| |..|...|.| ......|.. . ||. . .. ....| . | .  || .| |    |..
pdekchtvpqrll....aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar

0048179 (Phosphotyrosine protein) phosphatases II 763-928 6.4e-20 66.8 In-house 27-139 (144) alignment
Range on Protein: 763-928
Range on HMM: 27-139/144.0
EQQSRTIVCLCSPYELGKVCPQywptkeggpgtqlygnilvtlkggasgehyftstllirnvekslcrpVTHYWFSNWLDSEIPSSPQALMSMLLQVHNT
... .|...|...||   . ..                                               ...|.. .| | ..|.... | ..|  ... 
klgittvinlteeyepeflere...............................................giqylhlpwpDhgvpdllellleflefieea

HQESyGPVVVHCSDGVGRTGLVIATDINMqrleeSHTVDIPHTVSSIRQDRGQAILNIDQYAFIYR
..|. |||.|||| ||||||...| .. .      . ... ...  .|. | .|. | .|. |...
leeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 796-930 1.9e-21 71.7 In-house 11-139 (145) alignment
Range on Protein: 796-930
Range on HMM: 11-139/145.0
QLYGNILVTLKGGASGEHYFTSTLLIRNVEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESyGPVVVHCSDGVGRTGLVIATDINMQrle
  .|.. ..|.     .. .|  | . . .. | | ...|.. .| | ..|.... |...| .... ..|  |||.|||| ||||||...| .. ..   
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll...

esHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTL
  . |......  .|. | .|. | .|. |.|. .
..lgvsleealelvrsqrpgavpnpgqlrflyefe

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 824-926 1e-09 32.3 In-house 182-280 (302) alignment
Range on Protein: 824-926
Range on HMM: 182-280/302.0
VEKSLCRPVTHYWFSNWLDSEIPSSPQALMSMLlQVHNTHQESygpVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQY
..| . ..|    || | |   |  ... . .| .  ......   |.|||| |||||| ..|    .|   . .. |. . |  .|| |  |. . .| 
kkkkvkktvdilafsawpdhGapkeaytaldil.kfcesykkn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql

AFI
 ..
iyl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 829-932 2.8e-15 50.6 In-house 88-192 (440) alignment
Range on Protein: 829-932
Range on HMM: 88-192/440.0
CRPVTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQ-ESYGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIY
.| . .| .  | |  .|     .. |. .| ....  . ||..|||| |.||||..|| |  ..  . |  .||   ..|.|..| | .   .||||..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

RTLYE
 .. |
eavle

subfamily_PTPDC1_pd Subfamily PTPDC1 831-938 7.4e-07 23.8 In-house 82-176 (182) alignment
Range on Protein: 831-938
Range on HMM: 82-176/182.0
PVTHYWFsNWLDSEIPSsPQALMSMLLQVHNTHQESygPVVVHCSDGVGRTGLVIATDINMqrleeSHTVDIPHTVSSIRQDRGQAILNIDQYafiyRTL
 ...| |  | | . .|  . .. .   |. . ||    | |||  | ||||..||. .       .. ..  .... .|. | ..|   .|     ...
giyvynf.gwkDygvas.leriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvy.....akrltaekaiklvrskrpksiqtreqv....elv

YEFSKFLS
 ||..||.
kefalfli

PTPc_DSPc_SM00012 832-931 6.5e-30 98.8 In-house 2-104 (105) alignment
Range on Protein: 832-931
Range on HMM: 2-104/105.0
VTHYWFSNWLDSEIPSSPQALMSMLLQVHNTHQESY--GPVVVHCSDGVGRTGLVIATDINMQRLEES-HTVDIPHTVSSIRQDRGQAILNIDQYAFIYR
|.||....| | ..|.........| .|.. ...|.  .|||||||.|||||| ..| || .|.||.. ..|||  .|...|. | ... . .|| |.||
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TLY
 | 
all

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 832-932 1.1e-09 32.5 In-house 217-342 (350) alignment
Range on Protein: 832-932
Range on HMM: 217-342/350.0
VTHYWFSNWLDSEIPSSPQALMSMLL---------QVHNTHQ-ESYGPVVVHCSDGVGRTGLVIATDINMQ---R----LEESHTVD--------IPHTV
| .  . ||.|. .   |. ....|            ..  . .   |..|||| |||||| ... |  ..         .||. .|        |  .|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

SSIRQDRGQAILNIDQYAFIYRTLYE
  .|. | . . |.||. ||| .|  
nelrkqrismvqnldqfifiYeallf

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 839-933 6.5e-06 19.7 In-house 227-343 (349) alignment
Range on Protein: 839-933
Range on HMM: 227-343/349.0
NWLDSEIPSSPQALMSMLLqVH-----------NTHQESYGPVVVHCSDGVGRTGLVIATDINMQ--RLE--ESHTVD--------IPHTVSSIRQDRGQ
||||. .   |....  |  |              ...   ...|||| | |||| ..  |. ..       ||  ..        |  .| ..|. | .
nwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqris

AILNIDQYAFIYRTLYEF
 . |. |. .|| .| ..
mvqnlaqfiaiyealLky

0038934 (Phosphotyrosine protein) phosphatases II 841-929 1.1e-06 23.9 In-house 88-172 (194) alignment
Range on Protein: 841-929
Range on HMM: 88-172/194.0
LDSEIPSSPQALMSMLLQVHNTHQE-SYGPVVVHCSDGVGRTGLVIATDInmqrlEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRT
 |   . | . |.. |  |.  ..| . | |.|||  |.||||...|  .      ...  .    .  .|. |. || |.|..  ... 
pddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdyleallkr

subfamily_CDKN3_pd Subfamily CDKN3 842-937 3e-07 24.2 In-house 109-199 (202) alignment
Range on Protein: 842-937
Range on HMM: 109-199/202.0
DSEIPSsPQALMSMLLQVHnTHQESYGPVVVHCSDGVGRTGLVIATDINMqrLeeSHTVDIPHTVSSIRQDRG-QAILNIDQYAFIYRTLYEFSKFL
|  .|. . . . .| ... .  ..|   .|||  |.||. ||||  . .  |  . |..  ......|. .| .||  . || ..       ...|
dglvpd.iasclkileelr.inlkayrktlvhcygglgrsslviacllly..l..ddtiepkdaidklrdlkgsraiqtvkqynylsefrdkleeyl

subfamily_CG42327_pd Subfamily CG42327 862-937 7.5e-41 134.8 In-house 242-318 (319) alignment
Range on Protein: 862-937
Range on HMM: 242-318/319.0
THQESYGPVVVHCSDGVGRTGLVIATDINMQRLEES-HTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEFSKFL
 ..||.||.||||||||||||||||.||....|||| ..||||..|||.|.||..|.|...||.|||..|.|..|.|
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 867-929 1.3e-10 35.6 In-house 228-290 (297) alignment
Range on Protein: 867-929
Range on HMM: 228-290/297.0
YGPVVVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRT
  ...|||| ||||.|.|. .|. ...|   .  |.   .| .|. | . .  ..|. ..|  
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 871-933 3.5e-11 37.3 In-house 2-64 (69) alignment
Range on Protein: 871-933
Range on HMM: 2-64/69.0
VVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
||||| | ||||  ||  ..| |.     |||   |  .|. |   ..|  .| ||. .| | 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 871-933 5.5e-11 36.7 In-house 1-63 (69) alignment
Range on Protein: 871-933
Range on HMM: 1-63/69.0
VVHCSDGVGRTGLVIATDINMQRLEESHTVDIPHTVSSIRQDRGQAILNIDQYAFIYRTLYEF
||||| | ||||  ||  ..| |.     |||   |  .|. |   ..| ..| ||. .| | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea