Gene PTPN1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP055_AA protein Get Run
SpurP055_AA_13-286 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN1_pd Subfamily PTPN1 12-291 2e-146 481.3 In-house 3-277 (290) alignment 
Range on Protein: 12-291
Range on HMM: 3-277/290.0
EERKLWPTIFWDIHKESSlyELPTTDAKDPINKGLNRYRDIHPYNHTRIRLERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAII
. ..|. .|..||.||.|  ..||..||.| |..||||||..||.|.||.|||.|..||||||.|.. |||.||||||||..||.|||||||||.|.|..
dkkrlykeiyldirkeas..dfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

MLNNFVENHQQKCADYFPRGQDngnTDELLCEDTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSL
|||..||..|.|||.|.|.|..   ..|||.||| |||.....||..||.||.| ||.| ||.|.||||||||.|.||.||.||||||.||..||.||||
mlnkvvekeqikcaqywPqgee...ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsl

VDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEGSKVILRG
...|||.|||||||.|||||.||||||||.||||...|..|..|.||..|.||.|||||..||||||.|||||.||| . 
ssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 12-284 4.4e-37 122.6 In-house 17-278 (439) alignment 
Range on Protein: 12-284
Range on HMM: 17-278/439.0
EERKLWPTIFWDIHKESSLYELPTTDAKDPINKGLNRYRDIHPYNHTRIRL-ER---GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDS
......  ||  |   |  |.  .. | .  ..  |||.|. ...|||. | |        ||||  |.    .. || ||||   |. .||..|.|. .
nkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekkt

RAIIMLNNFVENHQqkcadYFPRGQDNgntdelLCEDTLLKVTylRQ-ERHHyYIVRTL--LLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHH
  |.|| |.|| ..     |.|  ..          |  ..|   |. |  . |..| .  . |   |.. . .|.|||. | |  ||   .  |.||. 
vtivmltnlvesyk.....ywpsdaev......cygdiavrvd..rnielpn.yvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflra

VRrSGSLVDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKgNTsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
.  |    ...|| |.||||||||.||.  .| .| |.  . |   .|..  .  .|. |. ..|.  |  | | |.|| 
in.sandkeeygpvvvhcsagvGrtGtiialdialeqlkle.nk..vdikgivkvlrkqrkqmvqalcqyvfiynavled
0050432 (Phosphotyrosine protein) phosphatases II 14-284 2.3e-80 265.5 In-house 41-298 (308) alignment 
Range on Protein: 14-284
Range on HMM: 41-298/308.0
RKLWPTIFWDIHKESSlyELPTTDAKDPINKGLNRYRDIHPYNHTRIRLeRGDVRYINASLIEAP--LAKRKYILTQGPLTRTVCHFWQMVWEQDSRAII
..|. . |... .      |... |. | || .|||.|| || |.|..|  ..  |||||..  .    .||.|.|||||  || .||.|||||..| |.
lglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIv

MLNNFVENHQQKCADYFPRGQDNGNTDEllcedTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGsl
||...||| ..||| |.|  ...| .         ..||.|..| ...|.|||| |..| ....... ||||| | |..||.||...|.||..||.|   
mLtklvengrekcaqYwplelgggsley.....gkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..

vDNvGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKgntSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
 .. || |.||||||||.||....|..| |.||.    |.|| . .  .|..|.| .|| .|..| | |.|| 
.pg.gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralley
0039614 (Phosphotyrosine protein) phosphatases II 15-283 8e-72 237.5 In-house 28-287 (297) alignment 
Range on Protein: 15-283
Range on HMM: 28-287/297.0
KLWPTIFWDIHKESSLYELPTTDAKDPINKGLNRYRDIHPYNHTRIRLER-----GDVRYINASLIEAPLA-KRKYILTQGPLTRTVCHFWQMVWEQDSR
.. .|...  ..|   .  ... |. | || .|||.|| ||.|.|..|        |  |||||... .   .||.|.|||||. || .||.|||||...
ansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvt

AIIMLNNFVENHQqKCADYFPRGQDngntdelLCEDtlLKVTYLRQERHHYYIVRTLLLEDlvTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRS
.|.||...||. . |||.|.|  ..        ..|  ..||.|. | ...|.|||| ...  ....... ||.|| | |..||.|.. .|.||. ||. 
vivmLtklvelgr.kcaqywpeegg.......tygd..ftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrea

GSLVDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKgntSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
 .  .. || ..||||||||.||... ...| |.||.    |.|| . .  .|..|.| .|| .|.|| | |.||
laelpkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydalle
0036941 (Phosphotyrosine protein) phosphatases II 20-285 3.9e-78 258.1 In-house 18-277 (297) alignment 
Range on Protein: 20-285
Range on HMM: 18-277/297.0
IFWDIhkESSLYELPTTDAKDPINKGLNRYRDIHPYNHTRIRLERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVEN
 | ..   . |.  ... |. | |. .|||.|| ||.|||..|. ..  |||||... .  |||.|.|||||  || .||.|||||... |.||...||.
efeel..lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel

HQQKCADYFPRGQDNGNTdellCEDtlLKVTYLRQER--HHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNVGP
  .||| |.|  ...  |    ..|  ..||.|. |   . .|..||| ..|. ....... ||||| | |..||.||| .|.|.. ||.  .|  . ||
grekcaqywpleegeslt....ygd..ftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

PVIHCSAGVGRSGTLCLVDTCLVQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEGS
 ..|||||||||||....|..| |.|.|  . |.|. . .. .|..|.| .|| .|.|| | |.||  
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_PTPN6_pd Subfamily PTPN6 20-282 7.1e-65 214.0 In-house 31-294 (306) alignment 
Range on Protein: 20-282
Range on HMM: 31-294/306.0
IFWDIHKESSLYELPTTDAKDPINKGLNRYRDIHPYNHTRIRLERGDV---RYINASLIE--APLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLN
 | .. .| . . |  .... | ||  |||. | |..|||. |.. .|    ||||. |.  ..  ...|| ||| |. ||  ||.|||...|| |.|. 
efeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmtt

NFVENHQQKCADYFPRGQDNGNTDEllcedtlLKVTYLRQERHHYYIVRTLLLED-LVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVD
. ||  ..||| |.|  ... .. .       ..|| ........||.|.|...     ....|. ..|.. | | .||..| |.|.||..|.|  . . 
kevErgkekCarYWPdeeekeeyGk.......isvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

--NVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAIL
  . || |.|||||.|| ||. ..|. | .|||||.   .|..|    .|..| ||.|| || .| | || 
eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
0046845 (Phosphotyrosine protein) phosphatases II 21-285 3.7e-78 258.1 In-house 6-274 (284) alignment 
Range on Protein: 21-285
Range on HMM: 6-274/284.0
FWDIHKESSLYELPTTDAKDPINKGLNRYRDIHPYNHTRIRLER-----GDVRYINASLIEAP-----LAKRKYILTQGPLTRTVCHFWQMVWEQDSRAI
|. . .    ..|... |. | |. .|||.|| ||.|.|..| .     .|  |||||... .       |.|.|.|||||  || .||.|||||..| |
feellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvI

IMLNNFVENHQQKCADYFPRGQDNGNTDEllcedtlLKVTYLRQERHHYYIVRTLLLEDLV-TQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSG
.||...||| ..||| |.|  ..  . ..       ..||.|. | ...|.|||| |..|  |...... ||||| | |..||.||. .|.||. ||.. 
VmltelvengrekcaqYwplegevltygd.......ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

SLVDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEGS
. ... || |.||||||||.||....|..| |.||.| ..|.|| . .  .|..|.| .||..|.|| | |.||  
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 21-283 1.2e-72 240.6 In-house 33-302 (307) alignment 
Range on Protein: 21-283
Range on HMM: 33-302/307.0
FWDIHKESSLYELPTTDAKDPINKGLNRYRDIHPYNHTRIRLER-----GDVRYINASLI--------EAPLAKRKYILTQGPLTRTVCHFWQMVWEQDS
| .. ..   .  ... |. | || .|||.|| ||.|||..|       .|  ||||| .        . .  |||.|.|||||  || .||.|.|||..
fekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgv

RAIIMLNNFVENHQQKCADYFPRGQDNGNTDEllcedtlLKVTYLRQERHHYYIVRTLLLEDL-VTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVR
..|.||...||. ..||| |.|  ..  . ..       ..||.|. | ...|.|||| ..||  |... .. |||||.| |..||.|.. .|.|.. ||
tvivmltelvelgrekcaqywPdegeeltygn.......ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

RSGSLVDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
.  .  .. || ..||||||||.||... ...|.|.|| | .. .|... .  .|. |.| .|. .|.|| | |.||
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 21-284 2.5e-38 126.6 In-house 11-265 (283) alignment 
Range on Protein: 21-284
Range on HMM: 11-265/283.0
FWDIHKESSLYELPTTDAKDPINKGLNRYRDIHPYNHTRIRLERGDVRYINASLIE---APLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFV
| .  |. |. .|... |    ||  ||...| |..  |..|.     ||||. |        ..||| .|.|| |||  ||.||....  ||.|| .. 
frevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklq

ENHQQKCADYFPRgqdNGNTDelLCEdtlLKVTYLRQERHHYYIVRTLLLEDL-VTQQTKEILHFHYTRWSDFSvPQSPAAFLQFLHHVRrSGSLVDNVG
|. ..||. |.|.   .|  |    |   . ||  ..  .. .|.. |||     ...|  . |. .  | ... .|..   |  .  |. |     . |
edlrikCsqyWPk...rGsed..yGe...ftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvi.slqteskkg

PPVIHCSAGVGRSGTLCLVDTclvQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
| |.|||.|.||..... . .    ...    | .|| . .  ||  | ...|| .| .. . ..|| 
PivvhCstgiGrtavfiaasa...svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_PTPRG_pd Subfamily PTPRG 23-283 1.1e-54 180.7 In-house 27-285 (563) alignment 
Range on Protein: 23-283
Range on HMM: 27-285/563.0
DIHKESSLYELPTTDAKDPINKGLNRYRDIHPYNHTRIRLER-----GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFV
....|.   .|... ...| ||  ||| .| .|...|..|.      ..  ||||. |.    ....| |||||. |.  ||.|.||| .  |.|. |.|
alqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlv

ENHQQKCADYFPRgqDNGNTDELlcedtlLKVTYLRQERHHYYIVRTLLLEDLVTQQ------TKEILHFHYTRWSDFSVPQSPAAFLQFLHhvRRSGSL
|....||  |.|.  |.  | .       |.||  ..|.. .| |||| ...|  ..       |.. ..|||.| | .||....  |.| .  ..| . 
ergrrkcdvYWPk..desetyga......lqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk..kssaan

VDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
 ...|| |.||||||||.||.. .|| | ||...      .| . |  .|  |  |.||  |  | . |.||
kaeaGPivvHcsaGvgrtGtyivldtllkqiqqena...vnvfgflkhiraqRnflvqteEqYiflhdalle
0043336 (Phosphotyrosine protein) phosphatases II 26-283 8.8e-71 233.9 In-house 28-275 (278) alignment 
Range on Protein: 26-283
Range on HMM: 28-275/278.0
KESSLYELPTTDAKDPINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQ
.  |    ... |. | || .|||.|| ||.|.|..|.  .      |||||... .  .||.|.|||||. || .||.||||.... |.||...||...
ellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgr

QKCADYFPrgqdngnTDELLCEDtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvDNVGPPVIH
.||| |.|        . | ..|  ..||.|..| ...|.|||| ...| . ......|.||. | |..|| |.. .|.||. ||.  .  |. || ..|
vkcaqYwp.......ggsltygd..ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVH

CSAGVGRSGTLCLVDTCLVQIEKKGntsGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
|||||||.||.......| |.|| |   |.|. . . ..|..|.| .|| .|.|| | |.||
CsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 26-283 1.3e-59 197.0 In-house 38-288 (298) alignment 
Range on Protein: 26-283
Range on HMM: 38-288/298.0
KESS-LYELPTTDAKDPINKGLNRYRDIHPYNHTRIRLER----GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENH
. || . |  .. |. | ||  ||| || .....|..||.     .  ||||| ..|   .  .|.||.|||.||  ||.||.|.|. .|.||.| .| .
svsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeld

QQKCADYFPRGQDNgNTDELLCedtllkvTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNVgPPVI
. |.  |.|  . . . .|.         . |..|..  .|||.| ...  .....|. ..|.| |.| .||.   . |..|..||.| .   |. | ..
ktkyhkywPdegke.tygeitv.......sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnk.pviv

HCSAGVGRSGTLCLVDTCLVQIEKKgntSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
.|||||||||| . .|. | ...|.   . .||.. .  .|. | |..|| .|  | | |.||
qCsaGvgRsGtfiaidsvlervkke...qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
DSPc_SM00195 27-283 3.6e-69 228.4 In-house 16-260 (263) alignment 
Range on Protein: 27-283
Range on HMM: 16-260/263.0
EsslyelPTTDAKDPINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQ
.      .||.|. . ||  |||..| ||.|||..|.. .      ||||. |. .  |.|||.|||||  || .||.||||.... |.||....||...
k......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengke

KCADYFPRGQdngntD-----EllcedtLLKVTYLRQERHH-YYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVdnVG
||..|.|. .     .     .       ..|.  ..| .   .|.||| |.   ...|... ...|. | | .||.|.  .|..|. |. | |     |
kcdrywpees.....ggketfg......kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sg

PPVIHCSAGVGRSGTLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
| |.||||||||.||....|..| ..|.. .   .|. . .  .|  |.|..|| .|..| | ||||
pivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 27-283 3.6e-69 228.4 In-house 16-260 (263) alignment 
Range on Protein: 27-283
Range on HMM: 16-260/263.0
EsslyelPTTDAKDPINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQ
.      .||.|. . ||  |||..| ||.|||..|.. .      ||||. |. .  |.|||.|||||  || .||.||||.... |.||....||...
k......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengke

KCADYFPRGQdngntD-----EllcedtLLKVTYLRQERHH-YYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVdnVG
||..|.|. .     .     .       ..|.  ..| .   .|.||| |.   ...|... ...|. | | .||.|.  .|..|. |. | |     |
kcdrywpees.....ggketfg......kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sg

PPVIHCSAGVGRSGTLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
| |.||||||||.||....|..| ..|.. .   .|. . .  .|  |.|..|| .|..| | ||||
pivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaile
0049772 (Phosphotyrosine protein) phosphatases II 28-289 4.7e-39 130.3 In-house 31-284 (314) alignment 
Range on Protein: 28-289
Range on HMM: 31-284/314.0
SSLYELPTTDAKDPINKGLNRYRDIHPYNhTRIRLER---GDVRYINASLIEAPlakRKYILTQGPLTRTVCHF----------WQMV--WEQDSRAIIM
| | || .. |... |.  ||| || |.. .| .| .    .. ||||| .  .   .|.| |||||  ||. |          |.||  .....| | |
svlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LNNFVENHqqkcadyfprgqdngntdellCEDTLLKVTYLRqE-------RhhyyivrtllledlvtqqTKEILHFHYT
                     |... .|.                     .| |   . .|. |                          ..........
srdevladelsrLdaAlgKtpllildgng.....................neptaadlellk.eelydpelf..................erlgikylri

RWSDFSVPqSPAAFLQFLHHVRRSgslvDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIekkgntsGLDVRKQLLDMRRYRH-----GLIQTWQQLRFSYC
 ..|.|.| ... |..||.....     |. || ..||.||.||.||..... .. .        |..... | |.|. |.     |.|.. .|. | . 
pvpDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefile

AILEGSKVIL
|.||  | ..
alleylkflk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 29-127 1e-07 25.7 In-house 20-120 (332) alignment 
Range on Protein: 29-127
Range on HMM: 20-120/332.0
SLYELPTTDAKDPINKGLNRYRDIHPYNHTRIRLERGD--VRYINASLIEAPLAKRKYILTQGPLT-RTVCHFWQMVWEQDSRAIIMLNNFVENhQQKCA
|    | |  |   |  .||   .. ..|.|. |   |    . ||| ..    |  ||..| |.  .|   ||.|| |.    |... .  |. |.. |
samtypntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek.qkrka

DY
 |
py
0047943 (Phosphotyrosine protein) phosphatases II 31-283 1.7e-77 255.9 In-house 26-270 (273) alignment 
Range on Protein: 31-283
Range on HMM: 26-270/273.0
YELPTTDAKDPINKGLNRYRDIHPYNHTRIRLERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPR
 .|... |. | || .|||.|| ||.|.|..|. |.  |||||... .  |||.|.|||||  || .||.|||||..| |.||...||....||| |.| 
plltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpl

GQDNgntDELLCEDtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNVGPPVIHCSAGVGRSG
 ...    .| ...  ..||.|..| ...|.|||| |..| |...... ||||| | |..||.|.. .|.|...||.  . . . || |.||||||||.|
egge...lsltygk..ftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtg

TLCLVDTCLVQIEKKGntsGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
|....|..| |.||.|   |.|| . .  .|..|.| .|| .|.|| | |.||
tfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 31-284 1.5e-35 117.4 In-house 33-235 (392) alignment 
Range on Protein: 31-284
Range on HMM: 33-235/392.0
YELPTTDAKDPINKGLNRYRDIHPYNHTRIRL----ERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHqqkcad
   |.| |. .||.  |||..| ||. .|..|    .  |  |.||| |..  ... || .||| . ..  ||.||....  .|.|.... |        
diypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

yfprgqdngntdellcedtllkvtylrqerhhyyivrtllledlVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSgsLVDNVGPPVIHCSAGV
                                              .... .  ||.| | |  ||.  ...|.|.. |.      .   | .|||||||
............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad..fGqythpliihcsagv

GRSGTLCLVDTCLVQIEKkgnTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
||.| .  .|. . . .|   |  .|| . . ..|| |  ..|| .|  | | |.|| 
grtgvvisidsvvahakk...trmvdvfnfvtnirrkrpymvqtkeqyafiygavled
0051299 (Phosphotyrosine protein) phosphatases II 32-283 1.8e-77 255.9 In-house 38-284 (288) alignment 
Range on Protein: 32-283
Range on HMM: 38-284/288.0
ELPTTDAKDPINKGLNRYRDIHPYNHTRIRLER----GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADY
 |... |. | |.  |||.|| ||.|.|..|      ..  |||||.|. .  |||.|.|||||  || .||.|||||..| |.||...||. ..||| |
dltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqY

FPRgqdngnTD-----EllcedtlLKVTYLRQERHHYYIVRTLLLEDL----VTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvDNVGPP
.|        .     .       ..||.|. | ...|.|||| ...|     ....... ||||| | |..||.|| ..|.||..||.. .  .. || 
wpl......ggsltygd.......itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..sgggpv

VIHCSAGVGRSGTLCLVDTCLVQIEKKgntSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
|.||||||||.||....|..| |.||.    |.|| . .  .|..|.|..|| .|.|| | |.||
vVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_PTPRD_pd Subfamily PTPRD 32-283 1.4e-71 236.9 In-house 37-279 (564) alignment 
Range on Protein: 32-283
Range on HMM: 37-279/564.0
ELPTTDAKDPINKGLNRYRDIHPYNHTRIRLERG----DVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADY
. ... |. |.||  ||| .| .|.|.|..|..     .  ||||| |..  ....|| ||||| .|.  ||.|||||.|. |.||.. .|....||..|
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

FPRGQdNGNTDEllcedtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvDNVGPPVIHCSAGVG
.|  . . . .|       |.||   .|.  .|..||. |..  .....|. .||.| | |  ||.|....|.....||.. .  .. || |.|||||||
WPekg.tetyge.......ltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVG

RSGTLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
|.|| . .| .| .|.....   .|... .  .|. |  ..|| .|  | . ||||
RTGtfividamlerikeekt...vDiyqyvkalrkqRnamVqteeQYiFiheaile
subfamily_PTPN12_pd Subfamily PTPN12 32-284 9.7e-59 193.6 In-house 29-276 (290) alignment 
Range on Protein: 32-284
Range on HMM: 29-276/290.0
ELPTTDAKDPINKGLNRYRDIHPYNHTRIRLER----GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADY
. .|. .. . |.  |||.|| ||...|. |..     .  ||||..|. .  | .|| .||||..|.  ||.|.||.. . ..|. . ||. ..||. |
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerY

FPRGQDNGntdellCEDTLLKVTYLRQERHH-YYIVRTLLLEDLvtQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvDNVGPPVIHCSAGV
.|  ...       .|   ..||  .... .  ...||| .|    ......  |||| | |  ||.|.   |.....||.  .  ..  | |.||||||
Wpeegeee......lefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGv

GRSGTLCLVDTCLVQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
|| ||.. .|    .....  .. ||| . .|..|. |. |.|| .| .. | |..| 
GrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_egg_pd Subfamily egg 32-282 1.2e-17 58.6 In-house 29-267 (307) alignment 
Range on Protein: 32-282
Range on HMM: 29-267/307.0
ELPTTDAKDPINKGLNRYRDIHPYNHTRIRLE--RGDV--RYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENhqQKCADY
| . | | .  |.   | . .|  . .|..||  ||     .| |  ..      ..||.| ||  ||  ||.||.... . |.||.  .|.  ..|  |
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

FPRGQDngntDELLCEDTLLKVTYLRQERHHYYIVRTLLLEDlVTQQTKEiLHFHYTRWsDFSVPQSPAAFLQFLHHVRRSGSlvdnvgPPVIHCSAGVG
.|. ..    | |      |... |. ...   . |   |   |  . .| ..  . .. |.         |. | ..|.         | |...  || 
wpkaes....dslvtvpGslrienlkvdskadplfrvtklkl.vGgddee.rflehwqg.dvnnssdvysplrvlrklrnlsk......pvvvqdilGvs

RSGTLCLVDTCLVQIEkKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAIL
...||  ... |...  .| .    |..    .|. |.  ...  .  | |  .|
kaatlvaieiallsll.rGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0040438 (Phosphotyrosine protein) phosphatases II 33-285 2.6e-75 248.9 In-house 33-276 (317) alignment 
Range on Protein: 33-285
Range on HMM: 33-276/317.0
LPTTDAKDPINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYF
 ... |. | ||..|||.|| || |.|..|   .      |||||... |  |||.|.|||||  || .||.|||||... |.||....|. ..||| |.
dtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYw

PRgqdngnTDELLCEDtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvDNVGPPVIHCSAGVGR
|        ..| ..|  ..||.|  | ......||| .||| .... .. ||||| | |..||.||  .|.||. ||.. .  |. || ..||||||||
pl......getltygd..ftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlVHCsaGvgR

SGTLCLVDTCLVQIEKKGntsGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEGS
.||.......| |.||.|   |.|| . .  .|..|.| .|| .|.|| | |.||  
tGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 33-284 1.3e-43 144.1 In-house 34-276 (315) alignment 
Range on Protein: 33-284
Range on HMM: 34-276/315.0
LPTTDAKDPINKGLNRYRDIHPYNHTRIRL----ERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYF
 ... |...||   |||..| |....|..|    .  |  ||||| |..    . || .||||  .|  ||.||....  .|.|...  |. . ||. |.
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PrgqdNGNTDelLCEDTLLKVTYLRQERHHYYIVRTLLLEDlvTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSgsLVDNVGPPVIHCSAGVGR
|    . ..|  . |   .||. |  |     ..| | . .  ..... .  |..| | |  |..  ...|.... |. .     .  . ..||||||||
P....drkad..svefGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGr

SGTLCLVDTCLVQIEKkgnTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
.| .. .| .. ||..   |. .|| . .  .|. |  |.|| ..  | | |.|| 
tGvvisidevvaqikr...trsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 33-283 6.4e-42 138.3 In-house 33-274 (515) alignment 
Range on Protein: 33-283
Range on HMM: 33-274/515.0
LPTTDAKDPINKGLNRYRDIHPYNHTRIRL----ERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYF
 | | |.. ||   |||..| ||. .|..|    .  .  |.||| |..  . . || .|||.  .|  ||..|....  .|.|...  |. . ||. |.
ypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyW

PRGqdNGNTdellCEDTLLKVTYLRQERHHYYIVRTLLLedLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDnvGPPVIHCSAGVGR
|     |..     .   .||  .  |     | |.| .  |  .... .  ||.| | |  ||.   ..|.... |. . . .    | .|||||||||
Pdk..pgds....vkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGr

SGTLCLVDTCLVQIEkkgNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
 | .. .| .. ...   .|  .|| . .  .|. |  |.|| .|  | | |.||
tGvvisidsvvahak...ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_PTPN3_pd Subfamily PTPN3 34-283 7.1e-63 207.1 In-house 32-273 (280) alignment 
Range on Protein: 34-283
Range on HMM: 32-273/280.0
PTTDAKDPINKGLNRYRDIHPYNHTRIRLERGDVRYINASLIEAPL----AKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFP
 .. |. | |   |||||| ||..||..|. ... ||||. ..  .    .  .|| |||||..|. .||||||||.|. |.|| . ||. ..||  |.|
aisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWP

RGQDNgntdellCEDTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLvdNVGPPVIHCSAGVGRS
. .|.       .| . ..|.  ...... |..| |.|.|  |.. ..||.. |. |.| .||...| ||.|...||.  |   .  | |.|||||.||.
etede.......leygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg..keePvvvhCsaGigrt

GTLCLVDTCLVQIEKKGNTSGLDVRKQlldMRRYRHGLIQTWQQLRFSYCAILE
| | |..|.|  ||.. .   ||. ..   ||  |  |.|| .| .|   |||.
Gvlilletalalieaaepvypldivrt...mrdqramlvqtasqykfvCeailk
subfamily_PTPRB_pd Subfamily PTPRB 34-281 6.1e-62 204.3 In-house 42-281 (293) alignment 
Range on Protein: 34-281
Range on HMM: 42-281/293.0
PTTDAKDPINKGLNRYRDIHPYNHTRIRL----ERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFP
 .. |. ..|.  |||..| ||.|.|..|    .. .  ||||. |.   ..|..| |||||  || .||.||||. |..|.|| . ||. ..|| .|.|
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWP

RGqdngntdELLCEDTLLKVTYLRQERHHYYIVRTLLLEDlvTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNVGPPVIHCSAGVGRS
.        |  .    .||| . .|. . ...|.|..|   ....... ..|.| |.|. ||......|.|...||.. .   . .| |.||||||||.
ad.......eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRt

GTLCLVDTCLVQIEKkgnTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAI
||.  .|. | .||.   .  .|.   . ..|. |  |.|| .|  | . ..
Gtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 34-283 9e-59 193.9 In-house 32-274 (281) alignment 
Range on Protein: 34-283
Range on HMM: 32-274/281.0
PTTDAKDPINKGLNRYRDIHPYNHTRIRL----ERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFP
..| .| . |.  |||..|  |..||...    |  .  ||||. ...   ...|| ||||.  .. .||||||||. .||.|. . .|. . ||  |.|
tataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP

RGQDngntdELLCEDtlLKVTYLRQERHHYYIVRTLLLeDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNvGPPVIHCSAGVGRS
 ..      ||   |  ..|. ...|... || |.. | .  . .|.|. ...|| | |  ||......|.| . |..  .   .  | ||||||||||.
ddns.....elkygd..vtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrt

GTLCLVDTCLVQIEKKgnTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
||   .|. . ..|..  .. |||.  . ..|. |  ..||  | .| | |.|.
GtyialDrlvkaveae..leeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 34-284 2.6e-56 186.0 In-house 39-282 (319) alignment 
Range on Protein: 34-284
Range on HMM: 39-282/319.0
PTTDAKDPINKGLNRYRDIHPYNHTRIRLER----GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFP
 .. |. ..||  |||..| .|..||. |       .  ||||| |..   ..|.| ||.||  |.  ||.||||..|  ..||.. ||. . |.  |.|
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp

RGQdngntdelLCEDTLLKVTYLRQERHHYYIVRTLLLEDLVTQQ-TKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNvGPPVIHCSAGVGR
. .          |   | || . .|. . ||.| | |. . ..  |.|. ||.|| |.|  ||..  . |..|...|.| .  .. || |.||||||||
een........feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs.gPivvhCsaGvGR

SGTLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
 || . .|  | .... |    ||| .    .|  |  ..|. .| .| | |.|| 
tGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 34-283 2.7e-41 136.6 In-house 42-282 (297) alignment 
Range on Protein: 34-283
Range on HMM: 42-282/297.0
PTTDAKDPINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAplAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQqKCADYFP
|.| |.. .|   .||..| ||.  |..|.  .      |.||| ...   | ..| || |   ||  ||.||....  .|.|||.  |... ||| |..
pqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg..nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

rgqDNGNTDellceDTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQ--SPAAFLQFLHHVRRSGSLVDNVgPPVIHCSAGVG
   |.| |         . |. |  .. . .| |.| ..   ..... .  .....| | .|..  | ...|.... || . | . .  | ..||.||||
...dkgvtt.....fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvG

RSGTLCLVDTCLVQIEKkgnTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
| | |. .| .. ....   .  .|. . .  .|. |  |.|| .| .| | |.||
rtgvlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavle
0045098 (Phosphotyrosine protein) phosphatases II 35-283 6.9e-66 217.8 In-house 25-270 (278) alignment 
Range on Protein: 35-283
Range on HMM: 25-270/278.0
TTDAKDPINKGLNRYRDIHPYNHTRIRlergDvrYINASLIEAPlaKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRgQDN
 |.|  . |. .|||.|| ||.|.|..    |  |||||.|. .  ..|.|.|||||  || .||.|.||.....|.||...||. ..||| |.|  .. 
itpalylgnldknRykdilpydhsrVk....d..YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggs

GNTDEllcedtlLKVTYLRQERHHYYIVRTLLLEDL----VTQQTKEILHFHYTRWSDFSVPQSP--AAFLQFLHHVRRSGS-----------LVDNVGP
 . ..       ..||.|  |....|..||||...|     . .. .. |.||. | |..|| .|  . ||..|  .|.  .           | |. ||
ltygd.......ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

PVIHCSAGVGRSGTLCLVDTCLVQIekkgNtSGLDVRKQLLDMRRYRHG-LIQTWQQLRFSYCAILE
 ..||||||||.|||......| ..    . .|.|. . .  .|..|.|  .|. .|.|| | ..||
vlVHCsaGvgRtGtlvaaylmlell....e.ggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPN14_pd Subfamily PTPN14 35-282 7.5e-55 181.0 In-house 41-293 (300) alignment 
Range on Protein: 35-282
Range on HMM: 41-293/300.0
TTDAKDPINKGLNRYRDIHPYNHTRIRLER---GDVRYINASLIEAPLA--KRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFP
.. || | |.  ||..|. ||...|..|      .  ||||| |.....  .|.|| .||||  ||. ||||||||. . |.|| .  |. ..|.  |||
lstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

RGQDNGNTDELlcedTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVR----RSGSLVD--NVGPP-VIHC
. ... .| |        |||   .|  . .| ..| |. | ... ....|. || |.|  ||. .  ||..|..|.    .. | |.  .. || ..||
kleskkktvef....gkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC

SAGVGRSGTLCLVDTCLVQIEKkgnTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAIL
||||||.| | |.|  .  .|.      .|..| |  .|. |  |.||  | .| | ...
saGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 35-284 8.6e-48 157.9 In-house 41-278 (315) alignment 
Range on Protein: 35-284
Range on HMM: 41-278/315.0
TTDAKDPINKGLNRYRDIHPYNHTRIRL----ERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPR
   ||.  ||  ||| .| .|...|..|       .  |.||..|.    ||.|| .|||.. .|  ||..|.|.|   |.||.| ||....|.  |.| 
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpd

GqdngntdELLCEDtlLKVTYLRQERHHYYIVRTLllEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGslVDNVGPPVIHCSAGVGRSG
        ...     . ||   .| .  | ||||     . .. .|.. .||| | |  ||..  .....  .|..     ..||. |.||||||||.|
k.......kviyGk..itvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh..tnsvgaivvhcsaGvGrtG

TLCLVDTCLVQIEKKgntSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
|.. .|. | |.| .     .|| . .  .|. | ...|. .| .| | |.|| 
tfitldavldqaeae...naidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_PTPN13_pd Subfamily PTPN13 36-284 5.4e-62 204.5 In-house 30-268 (273) alignment 
Range on Protein: 36-284
Range on HMM: 30-268/273.0
TDAKDPINKGLNRYRDIHPYNHTRIRLERGDVrYINASLIEAPLAKRK--YILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQD
. .|.  ||  ||||.. ||..||..|.     |||||||..|. | .  ||..||||  ||  ||||||||... |.|. . .|. . ||  |.|  ..
evgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPeskn

ngntdELLCEDTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRsgsLVDNVGPPVIHCSAGVGRSGTLC
     . |     |.|. |...... . ||.| ..|. .....|. |.... | | .||.|.| .|||. .|||   | .. || |.|||||.|||||| 
.....kklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr...lqtdagPivvhcsaGiGrsGtli

LVDTCLVQIEKKGntsGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
 .|. |  ||..     .||.. . ..|. |.|..|| .|  | | |||| 
tidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 36-282 8e-59 194.0 In-house 40-276 (288) alignment 
Range on Protein: 36-282
Range on HMM: 40-276/288.0
TDAKDPINKGLNRYRDIHPYNHTRIRLER----GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRG
| .. . |.  ||||.| ||...|..|.      .  ||||| |.    |.||| |||||. || .||..|.|...  |.||...||. ..|| .|.| .
tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda

QDNGNTDEllcedtlLKVTYLRQERHHYYIVRTLLLEdlVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvDNVGPPVIHCSAGVGRSGT
... |  .       ..|| . ..  . ...|.||||   ...  || ...|. |.| .||.| | .|..|. |  . .  ...|| ..||||||||.||
dkpknyGs.......vtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq..adtgpiivhCsaGvGrtgt

LCLVDTCLVQIEKkgnTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAIL
   .|. . ..|.   .  .||   .  .|. |  |.|| .|  | | ..|
Fialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 36-283 5.6e-58 191.5 In-house 39-278 (318) alignment 
Range on Protein: 36-283
Range on HMM: 39-278/318.0
TDAKDPINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRG
... .|.||  ||| .| .|.|||..|.  .      ||||. |.   .|..|| .|.||..|.  ||.|||||.|. |.|| . .|. ..|.. |.|  
lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk

QDNgNTDEllcedtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlVDNVGPPVIHCSAGVGRSGT
. . . ..       |.|.   . .  .|..|.. ..   .......  .||| |.| .||.|.| .|... .|..      ..|| |.|||||||| |.
gsr.sygk.......lvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqq.ksgagpivvhCsaGvGrtGv

LCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
 . ||. | .|.. .    .|| .    .|. |  ..|| .|  | | ..||
fiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiydvlle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 36-283 1.9e-44 146.7 In-house 39-281 (290) alignment 
Range on Protein: 36-283
Range on HMM: 39-281/290.0
TDAKDPINKGLNRYRDIHPYNHTRIRLE----RGD--VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFP
| .  . || |||...| .|.  || |     . |    ||||. |.    |..||.||||...|. .||...|.... .|.|| | .|....||  |.|
tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp

RGqDNGNTDEllcedtlLKVTYLRQERHHYYIVRTLLLEDLVT-QQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNvGPPVIHCSAGVGR
   |. . .|        ... | .| ...|| |.| ...  . ...... ... | | .    . |.. |. .... .      | .. |.|||..|||
ds.dtkayge.......fsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgn.tsivvHCSdtvgr

SGTLCLVDTCLVQIEKKGntsGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
|...| ..| . . ...|   . || . |  .|  . |..|| ||... .  .|.
savfcaaattinkckteg...vidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 36-282 3e-42 139.4 In-house 31-274 (287) alignment 
Range on Protein: 36-282
Range on HMM: 31-274/287.0
TDAKDPINKGLNRYRDIHPYNHTRIRLER---GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGq
  |..  .   ||| |. |...||. |       . ||||  . .   . ..| .|||.. ||  ||..|.|. | ..|..   ||. ..||  |.|   
kaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.

dngNTDELLCEDTLLKVTYLRQERHhyYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGS---LVDNVGPPVIHCSAGVGRS
   .   ..   ..  . |  .| .  | ||.| | || |.... .  ...  | | ... .  ....|   |..        ..|||.|.|...|.|||
...evPmrvGGysvvlldydikePe..ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrs

GTLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAIL
|.|  . ... . |. |.   .|| . .. .| || .|.|.  |||..| |. 
GillatlvlvsrledlGr...vdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 36-283 2.5e-36 120.5 In-house 41-286 (325) alignment 
Range on Protein: 36-283
Range on HMM: 41-286/325.0
TDAKDPINKGLNRYRDIHPYNHTRIRLE----RGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMV--WEqdsRAIIMLNNFVENHQQKCADYFP
. |  | ||  ||.... .....|. ||     ..  ||||| ..    |  .. .| ||| |.  .|..|  |.    ..... | ... ...|| |.|
kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavywp

RGQdnGNTDELlcedTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDN----VGPPVIHCSAG
.    |.. ..      |.|     |    |. | | . .    .|. .  |..  | |. |.. ||... .|. |      |       .| ..|||||
kem..gksktf....GglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaG

VGRSGTLCLVDTCLVQIekkGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
|||.|..  . . | ..    . | .|. . .  .|. |  ...|  |  . | |. |
vGrtGvfislysalakv...ieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_ptpA1_pd Subfamily ptpA1 36-235 3e-32 106.9 In-house 40-249 (418) alignment 
Range on Protein: 36-235
Range on HMM: 40-249/418.0
TDAKDPINKGLNRYRDIHPYNHTRIRLER----GDVRYINASLIEAPLAKrKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRG
..     |   ||| .| | ||||..|..        ||||  |.    | ..| |||||  |.. ||.||||.  | |.||.   || . ||  |.|  
segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

Q------DNGNTDELLCEDTLLKVTyLRQERHHYYIVRTLLLEdlVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVR-RSGSLV---DNVGPPVIH
         || .|..   ..  |  . |.  .  | | . |   .  .|..| ...|  | |. .|.    | |.|| .  |   ..   |   | ..|
iggeqfsiygngnevfgtysvelve.viqdpereiitrnirlt..fegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivh

CSAGVGRSGTLCLV
|||||||.||.|  
csagvgrtgtfcta
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 36-120 5.7e-10 33.2 In-house 89-174 (244) alignment 
Range on Protein: 36-120
Range on HMM: 89-174/244.0
TDAKDPINKGLNRYRDIHPYNHTRIRLERGDV--RYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNfVENH
 || .| |   ||     |..  |. | .| .   |||||..       .||||| ||. |   ||.|. |.    ...|   ||. 
kdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee
subfamily_PTPN9_pd Subfamily PTPN9 37-283 2.6e-55 182.5 In-house 36-288 (297) alignment 
Range on Protein: 37-283
Range on HMM: 36-288/297.0
DAKDPINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQ
 .| . |   ||| |.  |..||. |.. |      ||||. ..    |. .| ||||| .||  ||.|||||. . |.|   .||. . ||. |.| ..
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWplee

DNgntdelLCEDTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGS-LVDNV---------GPP-VIH
..        | . |.|. . .| .. | ||.| ...  |...... || .. | |. ||.| |..|..|..||.  . .|...         ||| |.|
es......saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvh

CSAGVGRSGTLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
||||.||.||.. .| || ..|..|.   .||.. .  .|  |   ||| .|  | | |.||
csaGiGrtGtfitldiclsrleevgt...vdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Ptp69D_pd Subfamily Ptp69D 37-285 2.4e-51 169.7 In-house 42-286 (307) alignment 
Range on Protein: 37-285
Range on HMM: 42-286/307.0
DAKDPINKGLNRYRDIHPYNHTRIRLER----GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGq
 ..   |.  ||| ||.....||..|..     |  ||||| |..   |.|.|  |.|.  |.  ||.|..||..  |.|| |  |  ..||| |.|   
vsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.

dngntDELLCEdtLLKVTYLRQERHHYYIVRTLLLEDLV-----TQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVdnVGPPVIHCSAGVG
     ||   .   . |.. ..|.|..|| |.| .          ....... .||| | |. ||... . |.....||   .|    .| |.|||||||
.....devqyg..dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvg

RSGTLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEGS
|||..  .|  | |...  .   .|. .   |.|. |  |.| ..|  | | |.|. |
rsgifvaldsllqqlkaedk...vdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPRK_pd Subfamily PTPRK 37-284 1.7e-50 166.6 In-house 37-276 (314) alignment 
Range on Protein: 37-284
Range on HMM: 37-276/314.0
DAKDPINKGLNRYRDIHPYNHTRIRLER--GD--VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPrgq
 ||.  |.  ||. || .|...|..|    ||    ||||.||..    ...| |||||  ||  ||..|..... .|.||...||. . ||  |.|   
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP...

DNGNTdellceDTLLKVTYLRQERHHYYIVRTLLLED--LVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLvdNVGPPVIHCSAGVGRSG
.....         .||.... | .  ..||.. .|      ....|. .|....|.|. ||.|  ..|.....|  |     . |. |.||||| ||.|
edtev......ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtG

TLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
| . .|. |  ||..|    .|| .   ..| ..  ...| .| .| | .||| 
tfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_PTPRN_pd Subfamily PTPRN 37-289 3.9e-45 148.8 In-house 50-296 (297) alignment 
Range on Protein: 37-289
Range on HMM: 50-296/297.0
DAKDPINKGLNRYRDIHPYNHTRIRLERG----DVRYINASLIEA-PLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPrg
 ||.. |   ||.... ||.|.|..|..     .  ||||| |      .  || |||||. ||..|||||||| .  |..| .  |.  ..|. |.|  
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp..

qDNGNTDELLCEDTLLKVtYLRqerHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSgsLVDNVGPPVIHCSAGVGRSGT
 |.|.    . |  |.   ..     . |.||.. | .| |..|. .  ||.  | . .|| |. ..|.|   | .|        | |.|||.|.||.|.
.deGsevyhiyevhlvse.hiw...cddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnks..yrGrscpivvhcsdGaGrtGv

LCLVDTCLVQIEKkGnTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEGSKVIL
 .|.|  | .. | |    .|.   |  .|  |.||..| .|..| . |. |  . ||
yilidlvlnrllk.G.vkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail
0040439 (Phosphotyrosine protein) phosphatases II 38-283 3.5e-66 218.7 In-house 6-244 (249) alignment 
Range on Protein: 38-283
Range on HMM: 6-244/249.0
AKDPINKGLNRYRDIHPYNHTRIRLER----GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRgqd
|. | || .|||.|| ||.|.|..|.      .  |||||.|. .  ||..|.|||||. || .||.|.||.....|.||...||. ..||| |.|    
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...

ngnTDELLCEDtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNVGPPVIHCSAGVGRSGTLC
    ..| ..|  ..||.|. | ...|.|||| |..| .... ..||..|| | |..||.|.. .|.|.. ||   .  .. || ..||||||||.||..
...ggsleygd..ftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

LVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
. ...| |.||...   .|.   . ..|..|.| .|. .|.|| | |.||
aaylmleqlekelg...vdleeavkllrsqRpgavqnpeqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 38-282 5.1e-62 204.9 In-house 5-239 (243) alignment 
Range on Protein: 38-282
Range on HMM: 5-239/243.0
AKDPINKGLNRYRDIHPYNHTRIRLerGDVRYINASLIEAPlakRKYILTQGPLTRTVCH----FWQMVWEQDSRAIIMLNNFVENHQQKCADYFPrgqd
|. | |.  |||.|| ||.|.|..|  ..  ||||.||. .   ...|.|||||. ||..    ||.|.||.....|.||...||. ..||| |.|    
allpenlsknrysdilpydhsrvkl..egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....

ngntDELLCEDtlLKVTYLRQERHHYYIVRTLLLEDLV-TQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSL------VDNVGPPVIHCSAGV
    .|  ..|  ..||.| .| ...|.||||||| |  ...|... |.||. | |..||.||. .|.||..||   .        |. || ..||||||
....gevtygd..ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRSGTLCLVDTCLVQIekkgntsGLDVRKQLLDMRRYRHG-LIQTWQQLRFSYCAIL
||.|||.. ...| ..       |.|. . . ..|. |.|  .|| .|.|| | |.|
gRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 38-284 1.3e-53 176.8 In-house 4-241 (250) alignment 
Range on Protein: 38-284
Range on HMM: 4-241/250.0
AKDPINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQkCADYFPRGQD
||.| ||  ||| || .....|. ||. .      ||||| ...   .. .| |||||..|. .||.||.|..| .|.||.|..|.... . .|.|  . 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

NGNTDellcedtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNvGPPVIHCSAGVGRSGTLC
.   |        ..|. | .| .  |..|.| |     .. . . ..|.. | | .||.   | |..|..|..|   ..| .| ...|||||||||. .
ekyGd........vtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagn.aPvivqCsaGvgrsGafi

LVDTCLVQIEKKgntSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
 .|. | ...|.     .||.| .  .|. | . ... .|  | | .||. 
aidavlerlkke...kvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 38-278 1.2e-38 127.4 In-house 32-262 (281) alignment 
Range on Protein: 38-278
Range on HMM: 32-262/281.0
AKDPINKGLNRYRDIHPYNHTRIRLER-----GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRgq
 ..|.|.  ||| .|   . .|..|.          || |  | .|. || |||||||   | . ||.|.|.... ||.|| .|.|  ..|||.||||  
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr..

dngNTDELLCEDTlLKVTYLRQERHHYYIvRTLlLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGslvdnvGPPVIHCSAGVGRSGTL
   |.   |  |  | |.|      .  .  |  |.     .|. | |. .  | |. ||.|   .|. |...|          ||||||||||||||||
...nahcclqfdk.lsvsyedstvnkslv.ttr.lnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars......tppvihcsagvgrsgtl

CLVDTCLVQIEKKGNtsGLDVRKQLLDMRR-YRHGLIQTWQQLRFSY
  |. .|  |  .      |... .  .|   |   .|| ||  . .
maveialqsihshft..lpdikqivshlrvtgraasvqtlqqymliw
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 38-283 6.5e-38 125.2 In-house 2-238 (239) alignment 
Range on Protein: 38-283
Range on HMM: 2-238/239.0
AKDPINKGLNRYRDIHPYNHTRIRLERG----DVRYINASLIEA-PLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPrgq
||  .||  ||| .|  |.|.|. ||.        ||||| .     . . || ||| .. .   ||.|.|..    |.||  ..| |..|| .|.|   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...

DngNTDElLCEdtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSgSLvDNVGPPVIHCSAGVGRSGTL
|  .| .  |.   |.||  . |    ||.||... ..   . . . ..|.| | |  |||  .| | . ... .  ||     | ||||||||||.|..
d..stsk.ycn...lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.sl.pgarpwvihcsagvgrtgaf

CLVDTCLVQIEKKgNTsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
 ..|. | | .|. .|  .|. . .  .|  |  ..|| .|  | . |.||
lvidamlrqakkq.kt..vdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 38-283 8.2e-38 124.9 In-house 3-239 (239) alignment 
Range on Protein: 38-283
Range on HMM: 3-239/239.0
AKDPINKGLNRYRDIHPYNHTRIRLERG----DVRYINASLIEA-PLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPrgq
||  .||  ||| .|  |.|.|. ||.        ||||| .     . . || ||| .. .   ||.|.|..    |.||  ..| |..|| .|.|   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...

DngNTDElLCEdtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSgSLvDNVGPPVIHCSAGVGRSGTL
|  .| .  |.   |.||  . |    ||.||... ..   . . . ..|.| | |  |||  .| | . ... .  ||     | ||||||||||.|..
d..stsk.ycn...lrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd.sl.pgarpwvihcsagvgrtgaf

CLVDTCLVQIEKKgNTsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
 ..|. | | .|. .|  .|. . .  .|  |  ..|| .|  | . |.||
lvidamlrqakkq.kt..vdifnyvkairedrphmvqtseqyvfihlavle
0042113 (Phosphotyrosine protein) phosphatases II 39-283 1.8e-65 216.0 In-house 5-241 (245) alignment 
Range on Protein: 39-283
Range on HMM: 5-241/245.0
KDPINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRgqdn
. | || .|||.|| ||.|||..|   .    . |||||..  .  ..|.|.|||||. || .||.|.||.....|.||....|....||| |.|     
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl....

gnTDELLCEDtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLvDNVGPPVIHCSAGVGRSGTLCL
   ..| ..|  ..||.|. | . .|.|||| ...| . ...|..|.||. | |..|| ... .|.||. ||.  .  |. || ..||||||||.||...
..gesltygd..ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfia

VDTCLVQIEKKGntsGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
....| |.|| .   |... . . ..|..|.| .|| .|.|| | |.||
aylmleqlekel...gvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPRA_pd Subfamily PTPRA 39-283 1.2e-49 164.0 In-house 54-293 (330) alignment 
Range on Protein: 39-283
Range on HMM: 54-293/330.0
KDPINKGLNRYRDIHPYNHTRIRLER--G--DVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPrgqDN
.   ||  ||. .| ||...|. |    |  .  ||||| |.    | |.| .|||...||  ||.|.|||.| .|.|| .. | ...||| |.|   |.
skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP...de

GNTDellceDTLLKVTYLRQERHHYYIVRTLLLEDL----VTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNvgPPVIHCSAGVGRSG
|           ..|.   ..    | || .|...|      .... .  ||.| | |. ||  |   |..|..|..      .  | |.||||||||.|
Glvt.....yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtG

TLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
|.. .|. | ... ..    .|| . .  .|  |  ..|| .|  | | ..||
tfivldavlervkaerk...vdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 39-284 5.8e-45 149.0 In-house 57-290 (319) alignment 
Range on Protein: 39-284
Range on HMM: 57-290/319.0
KDPINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNnfvenhQQKCADYFPRGQDN
  . ||  ||. .| ........||| .      ||||| ..    | ||| .||||  |.  ||.|.||... .|..|       ..||..|.|   . 
nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi

GNtdellcEDTLLKVTYLRQERHhyYIVRTLLLE-DLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNVGPPVIHCSAGVGRSGTLC
 .      |   .||. . .     |.|| . |  |   .. ..|  ||.  | |  ||..|. .......||   |  ..  . |.||||||||.|.  
ke......erfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyi

LVDTCLVQIEKKgntSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
 .|. | .....   . .|| . . |.|. |  |.| . |  | | |.|| 
vldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 39-282 6e-33 108.9 In-house 44-284 (305) alignment 
Range on Protein: 39-282
Range on HMM: 44-284/305.0
KDPINKGLNRYRDIHPYNHTRIRLERG-DVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGN-
|.  ..| |||.|.   .. |..||      || |  . .|   ...| || || .|   || | ...   ||.|| |..|   .||..||.  ...   
keaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

---TDELLCEDTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSgslvdnVGPPVIHCSAGVGRSGTLC
    .. .       ||.  ..  .  . .| |. .   .... . |.|.  | |  || .  | |..|.. | |       || |.|||||.||.|.. 
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps......kgpivvhcsagigrtgsvv

LVDTCLVQIEKkGNTSGlDVRKQLLDMRRYRHGLIQTWQQLRFSYCAIL
...  | |.   |.    |  | |  .|  |   ||| .|  | .  ||
mleyildqlla.gqiie.dtdkilqkireqrnnsiqtdaqylfvhqvil
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 40-283 1.8e-46 153.7 In-house 43-281 (305) alignment 
Range on Protein: 40-283
Range on HMM: 43-281/305.0
DPINKGLNRYRDIHPYNHTRIRLER----GDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQdnG
.  ||  ||...| .... ||.|      .|  ||||| ...   | |||..||||  ||  ||....|   . |.|| . ||. ..||  |.|  .  .
keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesk..t

NTDELlcEDTllKVTYLRQERHHYYIVRTLLLED-LVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLvDNVGPPVIHCSAGVGRSGTLCL
.. |.  ...  .|.   ..    || | | .      .... .|... | | |  |||.....|.....|... .  |.  | ..||||||||.|. . 
ekkef..gef..svelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkgvpllVhCsagvgRtGvfia

VDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
||  | ...| .    .|| . |  .|. | ...|| .|  | . |. |
vdialerlkkEev...vdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 41-284 1.4e-44 147.7 In-house 23-254 (284) alignment 
Range on Protein: 41-284
Range on HMM: 23-254/284.0
PINKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNnfvenhQQKCADYFPRGQDNGN
. ||  ||. .| ........||| .      ||||| |.    | ||| |||||  |.  ||.|.||... .|..|       ..||..|.|   .  .
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

tdellcEDTLLKVTYLRQERHhyYIVRTLLLE-DLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNVGPPVIHCSAGVGRSGTLCLV
      |   .||. . .     |.|| . |  |   .. ..|  ||.  | |  ||..|. .......||   |  ..  . |.||||||||.|.   .
......erfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

DTCLVQIEKKgntSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
|. | .....   . .|| . . |.|. |  |.| . |  | | |.|| 
dvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 41-282 2.4e-44 146.4 In-house 45-275 (287) alignment 
Range on Protein: 41-282
Range on HMM: 45-275/287.0
PINKGLNRYRDIHPYNHTRIRLERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDngntdEL
. || .||...| ...  |. |.  .  ||||. |..   |...|....|...|.  ||......   ||.|| .  ||....| .|.| ..       .
sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.....vv

LCEdtlLKVTYLRQERHHYYIVRTLLLEDLV-TQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNvGPPVIHCSAGVGRSGTLCLVDTCL
| |    ... | .|... ||.|.| ..    .......  ...| | .    ..|.. |  ...  ..     | .. |.|||..||||...| ..| .
lGe...yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgn.tsivvhCsdtvGrsamfcaaatti

VQIEKKGntsGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAIL
 . .. |   ..|| . |  .|  . | .|| .| .| . ..|
nkckteG...viDvfqvlksqriqkpgsvqtveqykfindivl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 41-273 4.4e-29 96.1 In-house 53-277 (305) alignment 
Range on Protein: 41-273
Range on HMM: 53-277/305.0
PINKGLNRYRDIHPYNHTRIRLERG-DVRYINASLIEAPLA-KRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQdnGNTD
 |..  |||.|.   ... ..|..   . || |  . .|.  ....| .|||| .|. .|| || ..    |.|| . ||  . |||.|.|  |  |.  
diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq..gekl

ELLCEDTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRrsGSLVdnvgPPVIHCSAGVGRSGTLCLVDTC
|| .   . .|.  .       |  |||      .|.  . |...| | |  ||    . |..|  .|  || |    | |.|||||.||.||.  ..  
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair..gskv....pivvhcsagigrtgtivaieyi

LVQIE-KKGNTSGLDVRKQLLDMRRYRhglIQTWQQ
| .|  .|      .. | | | | .    ||.  |
lekiaenkpcppmpelvkalrdqrafs...iqndvq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 42-286 8.1e-54 177.5 In-house 27-269 (274) alignment 
Range on Protein: 42-286
Range on HMM: 27-269/274.0
INKGLNRYRDIHPYNHTRIRLE-----RGDVRYINASLIEAPLAKRK-YILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNG
 ..  |||..| | ...|. ||       |  ||||  |  .  . | |. |||||. ||  ||.|....... |.|| .. |...|||| |||  .|  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

NTDEllceDTLLKVTYLRQERHHYYIVRTLLLEDLVTqqTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNV-GPPVIHCSAGVGRSGTLCL
 ...     . ....     ... | ||.|.|. |    .... |. || | |  .|... ..|.....|..| .  ..  .| |.|||||.|| |    
iser....ygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfia

VDTCLVQIEKkgnTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEGSK
.. .. |...   .. .|| |   ..|  | |..|| .| .. . |. .  |
isiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 42-281 2.4e-34 113.4 In-house 39-289 (301) alignment 
Range on Protein: 42-281
Range on HMM: 39-289/301.0
INKGLNRYRDIHPYNHTRIRLERG------DVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNG
 || |||...| .|.. || |.          .||||| |..   |.|.| .|||. .|.  ||...|..   .|.|. |  |. ..||  |.|... . 
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaes

NTDE----LLCEDTLL------KVT-YLRQERHHYYIVRTLLLEDLVtqQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDnVGPPVIHCSA
..      .| ... .      ...  ...   . || |..  .     .....| .. | | .  | . |.  || .. |      ..  || |.|||.
eefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkig.ggpvvVHCSd

GVGRSGTLCLVDTCLVQIEKKGNTSGLDVRKQlldMRRYRHGLIQTWQQLRFSYCAI
.|.|||. | |.  | |    |     .| |    .|| . | ..| .|  . | .|
tVsrsGvYcsvsiglEQckaegVVdvfqvtka...vrrskpgaVtTLeqytsiydvi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 42-276 4.1e-30 99.8 In-house 40-268 (307) alignment 
Range on Protein: 42-276
Range on HMM: 40-268/307.0
INKGLNRYRDIHPYNHTRIRLERG--DVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQdnGNTDE
 |   |||.|..  ...|| ..       || |  .   .  .|.| .||||  |. .|| |. ...  ..||| . .|  . || .|.|  .  |..  
antdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee..gqklv

LLCEDTLLKVTYLRQERH--HYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRsgslvdNVGPPVIHCSAGVGRSGTLclVDT
   .   . |. |  ..      ..    |.   .|... | |. .. | |  |||   . . .|. ||       .  | |.|||||||||||.  |  
fgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry......dtnpvvvhcsaGvGrsGti..vai

CLVQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRF
.|||          |..| . ..|  ||  |||  |  .
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqyly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 42-283 4.1e-26 86.6 In-house 34-268 (285) alignment 
Range on Protein: 42-283
Range on HMM: 34-268/285.0
INKGLNRYRDIHPYNHTRIRLERGDVRYINASLIEAPLA-KRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRgqDNGNTDEL
 |  |||| |..  . ||. |.  |  || || .  |   .  || |||||  |.  ||.|....    ..||  ..|   .||| |.|     |.  ..
anpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype..klgevvkf

lcEDTLLKVTYLRQERHHYYIVRTLLLEDL--VTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvdNVGPPVIHCSAGVGRSGTLCLVDTC
      . .|  ..|     |. .| . .    . .   . | .   | |   |.    .... . |..      .  | ..||||||||. |.  .| .
..gkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfvgidya

LVQIEKKGNTSGLDVRKqllDMRRYRHGLIQTWQQLRFSYCAILE
 ..| .. |   ||. .   .||  |   .|.  |. | |  ..|
tirimenpniemldivr...emramrfqavqshmqflflyvvlme
Y_phosphatase Protein-tyrosine phosphatase 43-283 1.6e-65 216.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 43-283
Range on HMM: 1-235/235.0
NKGLNRYRDIHPYNHTRIRL--ERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPrgqdngNTDEL
||  |||.|| ||..||..|  . |.  ||||. ..    |.|.|.|||||  |. .||.|||......|.||.. .|....|||.|.|      ...| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp......eeeee

LCEDTLLKVTYL-RQE-RHHYYIVRTLLLEDLVTQQ-TKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGslVDNVGPPVIHCSAGVGRSGTLCLVDT
 ..   .||..  ...  .. |..|.| |..  ... ..|. ..||| | | .||.|| ..|.... |..|    .. || |.||||||||.||....|.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldi

CLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
.| |.|....   .|| . .  .|. |.|..|. .|. | | ||||
lleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 43-283 1.6e-65 216.2 In-house 1-235 (235) alignment 
Range on Protein: 43-283
Range on HMM: 1-235/235.0
NKGLNRYRDIHPYNHTRIRL--ERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPrgqdngNTDEL
||  |||.|| ||..||..|  . |.  ||||. ..    |.|.|.|||||  |. .||.|||......|.||.. .|....|||.|.|      ...| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp......eeeee

LCEDTLLKVTYL-RQE-RHHYYIVRTLLLEDLVTQQ-TKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGslVDNVGPPVIHCSAGVGRSGTLCLVDT
 ..   .||..  ...  .. |..|.| |..  ... ..|. ..||| | | .||.|| ..|.... |..|    .. || |.||||||||.||....|.
sltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldi

CLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
.| |.|....   .|| . .  .|. |.|..|. .|. | | ||||
lleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 43-283 2.6e-55 182.3 In-house 20-262 (270) alignment 
Range on Protein: 43-283
Range on HMM: 20-262/270.0
NKGLNRYRDIHPYNHTRIRLERGD----VRYINASLIE-APLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRgqdnGNT
.| ||||.|| |  .||.|||. .      ||||  .. .  .|.||| ..|||  |. .||.|.||. ..||.|. ...|. ..||. |.|      . 
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa....epk

DELLCEDTLLKVTYLRQERHHYYIVRTLLLEdlVTQQTKEILHFHYTRWSDFSVPQSPA------AFLQFLHHVRRSGSLVDNVGPPVIHCSAGVGRSGT
... .||  .||. | .|... ||.. | ||   . ......||.|. | | .||...         |. |..|||| .  |. .| ..||||||||.||
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

LCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
| ..|...  .|....   .|| . . ..|..|  |.|. .| .| | |..|
lialDiavrlLeetkk...vdvlaiieelRkdRmalvqhpeqyeflykavve
0041856 (Phosphotyrosine protein) phosphatases II 43-284 8e-45 148.0 In-house 1-170 (182) alignment 
Range on Protein: 43-284
Range on HMM: 1-170/182.0
NKGLNRYRDIHPYNHTRirlergDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNnfvenhqqkCADYFPrgqdngntdellc
|. .|||.|| ||.|.|      |  ||||.|.  .|  ...|.||||| .|| .|..|..|.. ..|..|.         .  |.|             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

edtllkvtylrqerhhyyivrtllledlvTQQTKEILHFHYTRWSDFSVPQsPAAFLQFLHHVRRsgslvdNVGPPVIHCSAGVGRSGTLCLVDTCLVQi
                             .  ........|. | |..||  .  .|.|.. |..      . || ..||||||||.|||.. . .... 
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl.

ekkgntsGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
       |..... .  .|..|.| ..| .|..| . |.|| 
.......gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 43-283 3.1e-41 136.1 In-house 3-237 (237) alignment 
Range on Protein: 43-283
Range on HMM: 3-237/237.0
NKGLNRYRDIHPYNHTRIRLE--RGDVRYINASLIEAP-LAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGNtde
||  ||| .|  |.|.|. |.   ... ||||. ..    . .||| .||||  .   ||||||..    |.||  ..|. ..|| .|.|  ..      
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa...

llceDTLLKVTYLRQERHHYYIVRTLLLEDLVTQQTKE-ILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNVGPPVIHCSAGVGRSGTLCLVDTC
       | |.  ..|    | ||.|||   .|..    |  ...| | |  |||  ||.|.| ...      | . || .|||||||||.| . ..|. 
....ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam

LVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
| | ..|     .|. . .  .   |  .||| .|  | . .|||
lrqakekkv...vdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_CG7180_pd Subfamily CG7180 43-282 7.7e-40 131.4 In-house 42-287 (296) alignment 
Range on Protein: 43-282
Range on HMM: 42-287/296.0
NKGLNRYRDIHPYNHTRIRLER--G--DVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQqKCADYFPRGQdNGNTD
|.. ||. .. ||...|. ||.  |  .  ||||. ... | |..|| |..| ..||  ||..|..... |...| .  . .. .. .|.|  . . .  
nreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqyg

ELLCEdTLLKVTYLRQERHHYYIVRTL----LLEDLVTQQTKEILHFHYTRWSD-FSVPQSPAAFLQFLHHVRRSGSLV---DNVGPPVIHCSAGVGRSG
|.. | .. . .|   . . . .....      |  |. .|. ...|..| |    .|| | .|...... ||     |   .. || |...| |..|||
eifve.iveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

TLCLVDTCLVQIEKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAIL
  . .| .| ..||...   .|| . .  .|| | .|... .. .. |  .|
vylaidanlelvekeee...vdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 43-275 2.7e-30 100.3 In-house 33-249 (267) alignment 
Range on Protein: 43-275
Range on HMM: 33-249/267.0
NKGLNRYRDIHPYNHTRIRLERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCadYFPR-GQDNgNTDELL
|.  ||. |  ||..||. |   .  ||||| .|.   |...|.||.||  |. .|.... .|.   |..| .  ..  ..   . |. || . . ..| 
nqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlf..wPPkmgqak.kyqdlt

CEDTLlkvtylRQERHHYYIVrTLLLeDLVTQQTKEILHFHYTRWSdfsVPQSPAAFLQFLHHVRRSGSLVDNVGPPVIHCSAGVGRSGTLCLVDTCLvQ
 | .|       .|   | |. || |  .  . ....  ..| .|    .      .|. |  .     | .   | |..||.|||||||.  .|. | .
vehsl......ekeendyqii.tlel.kfknesahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsql.e

IEKKGNTsgLDVRKQLLDMRRYRHGLIQTWQQLR
  |. ..  .|. . |. .|  | ||..| ..  
raktegv..sdifdflrkirsqriglvdtkeryi
subfamily_CG42327_pd Subfamily CG42327 43-208 6.3e-26 85.8 In-house 28-193 (319) alignment 
Range on Protein: 43-208
Range on HMM: 28-193/319.0
NKGLNRYRDIHPYNHTRIRLER----GDVRYINASLIEAPL-AKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGNT
 |  .|. .. |  .||. |.|        |..|| .  .  |.  || .| .|  .   ||..|||| || |. | .  |.  ..||.|.|  .   ||
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

DeLLcEDtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYtRWSDFSVPQSPAAFLQFLHHVRRS
. |   |  ..||   .| .. |.. ||||  .  ....|. |. | .| .  || ..||..  | .|| |
s.ly.Gd..ilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 43-283 4.7e-22 73.0 In-house 47-277 (303) alignment 
Range on Protein: 43-283
Range on HMM: 47-277/303.0
NKGLNRYRDIHPYNHTRIRLErgDVRYINASLIEAPLAKrKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNgntdeLLC
|   ||. |.   .|....|   |  || || .|    | | |||| ||. | . ||||. ||  . ...|    | ..      ||| ||      |  
nmdknrfvdvicldhskvkls..dssyihasyleldssk.kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf.....lkf

EDTLLKVTYLRQ-ERHHYYIVRTLlleDLVTQQTKEILHF-HYTRWSDFSVPQS-PAAFLQFLHHVRRSGSLVDNVGPPVIHCSAGVGRSGTLCLVDTCL
|.  ..|  ... |  . . .. |    .   . | .||  ||  |   |.|    . |.. .  ..       .  |.|    .|.||.||..| .|. 
eersirvgefkrvelgdgwvlkvl...svsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

VQIEKkgNTSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
. . .  . . ||. | |  .|  |   .|   |. . |  . |
lslhs..eqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_PTPN23_pd Subfamily PTPN23 44-288 1e-55 183.6 In-house 44-283 (288) alignment 
Range on Protein: 44-288
Range on HMM: 44-283/288.0
KGLNRYRDIHPYNHTRIRLERGDVRYINASLIEAPLAK-RKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGNTDELlc
   ||.||| ||.|.|. |. .   ||||| ..   .   ..| ||.||  |.  ||.||.|| |. |.|| .  | ...|.. |.|  ... .. .   
seknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd..

edtlLKVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVD--NVGPPVIHCSAGVGRSGTLCLVDTCLV
    |.||  .... .... |.| || | ....|.. | ..| |... ||.||  .||||. |. . . |      | |.||||||||.|...|| . . 
....lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

QIeKKGNTSgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEGSKVI
.. .|||   ||. . .  .|. |.  .|. .||.||| |.||  . .
el.ekgngl.ldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 44-283 1.1e-26 88.3 In-house 44-274 (312) alignment 
Range on Protein: 44-283
Range on HMM: 44-274/312.0
KGLNRYRDIHPYNHTRIRLERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGNTDEL-LC
| |||| .|  ..  |. |   .  || | ..       ... |||||  |..||||..    | .||.|  |||.  .||| |        . ..  . 
kdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvy

EDTLLKVTyLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRsgslvdNVGPPVIHCSAGVGRSGTLCLVDTCLVQI
 .   ..  .    .     | | .    | |   . |. .. | |  .|.|  . |..|  |..      .  | . ||||||||.|||.|... .  .
teycteie.iggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk......dkkpviahcsagvgrtgtlaliesmiaal

EKKGNtsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
 .  .    .|.. .. .|. |   .... |  ..  ..||
rhprk...qnvkdsfvllrkdrarsvrvfpqyvyalrcvle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 44-196 3.3e-26 86.8 In-house 34-184 (297) alignment 
Range on Protein: 44-196
Range on HMM: 34-184/297.0
KGLNRYRDIHPYNHTRIRLERG--DVRYINASLIEAPL--AKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGNTDe
   ||||||  .. ||..| |.  .  ||||  .  |   |. ||||.|||| .||  ||..|.||| |.|.|. .. |. ..||| |.|. .... .  
lrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka.

llcEDTLlkVTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPA
    | .  | .| .   ..  |    |. .  .... . |  .  | |  ||    
...gdvv..veflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 44-282 5e-16 53.0 In-house 52-282 (302) alignment 
Range on Protein: 44-282
Range on HMM: 52-282/302.0
KGLNRYRDIHPYNHTRIRLERGDVRYINASLIEAPLAKRKYILTQGPLTRTV---CHFWQMVWEQDSRAIIMLNNFVENHQqKCADYFP-RGQDNGNTDE
   |.  |.  .......||     |.||| .| |  .|. ||.| | . ..    .||.||...    . .|    | ..    ..|| . .|  . ..
lkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygk

LLCEDTllKVTYLRQERHHYYIvrTLLLEDLVTQQTKEILHFHYtrWSDFSVPQSPAAFLQFLHHVRRSGSLVDNvgPPVIHCSAGVGRSGTLCLVDTCL
.       || .  .|...|.|   .| |.       .. ....  | . .||.. |.  .  ..|  . . .|.  . ||    |.|| |..  . . .
mfvNnr..kVekaeeektryvi..EvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakvfakkikade..ntvivSknGaGRagafltlavav

VQIEKKGNTSGLDVrkqLLDMRRYRHGLIQTWQQLRFSYCAIL
 ...|. .    ..   .  .|  |   ... .|  . | |.|
eklqkgkepnikei...vksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 46-273 8.6e-35 114.8 In-house 59-271 (290) alignment 
Range on Protein: 46-273
Range on HMM: 59-271/290.0
LNRYRDIHPYNHTRIRLERG-DVRYINASLIEAplAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGNTdelLCED
 |||.|.   . ||. |. | |  |. |  ..    |  .|||||.|. ||  .|.|| ...  ||.|| . .|. . ||..|.|  . .  |   . | 
knrykdvvcndktrvilkdGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt...fGei

TLLkvTYLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGslvdnvGPPVIHCSAGVGRSGTLCLVDTCLvQIEK
|.|    . ...    | .|| . |  . . . . |..   | | ||..|  |.|. |. .|.        || |.|||||.||.||.  ....| ||  
tvl..cseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkas......GpvvvhcsaGiGrtGtfvaievgl.qill

KGNTsgLDVRKQLLDMRRYRHGLIQTWQQ
.|    ||. .    .|. | . .|   |
dGke..ldlldlvralrnsrlnsvqvdiq
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 46-282 3.3e-32 106.7 In-house 46-268 (288) alignment 
Range on Protein: 46-282
Range on HMM: 46-268/288.0
LNRYRDIHPYNHTRIRLERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGNTDELLCEDT
 .||...   . ||..|.     ||.| .. .   ||. | .| ||  |.  .|.|. |.| . |.||....|  ..| |.|||  . .      || ..
rdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvv

llKVTYlrqERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVrrsgslVDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKK
  |. .   .  .  .. .||    ...... . . |.  | | .||..  ..|..|. .       .   | |.|.||||||.||| |.   |...  .
..kkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslrld

gntSGLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAIL
     | .|. |  .|  |   ||| .|  . .  .|
...dflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 46-273 1.2e-17 58.5 In-house 55-278 (310) alignment 
Range on Protein: 46-273
Range on HMM: 55-278/310.0
LNRYRDIHPYNHTRIRLERGDVR---YINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRgqdNGNTDELLC
 ||| |.   . .|..|.    |   || |  . .   .  .| .||||  |.  ||.|.... . .|..| . .|. . ||  |.|     | |.   |
knrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps...lgvtetygc

edtlLKVTYLRQERHHYYIVR---TLLLEDL-VTQQTKEI--LH---FHYTRWSDFSVPQSPAaflqflHHVRRSGSLVDNVGPPVIHCSAGVGRSGTLC
    ..|| | .  . . |.    |.. ... | .|  ..  |     ..  | |  ||.         | | .        || |.|||||..| ....
....irvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc......htvpqrllaqvrhgpcvvhcsagkdrlyvvv

lvdTCLVQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQ
   .  ..|.|  .   .|. .   .... |   |||  |
...alklkidkldrglkvdaeevktellksraiciqtelq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 46-137 1.4e-17 58.5 In-house 50-159 (350) alignment 
Range on Protein: 46-137
Range on HMM: 50-159/350.0
LNRYRDIHPYNHTRIRLERG------------DVRYINASLIEAP------LAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADY
 |||..| ||.|.|..|...               ||||. .. .       .. ||| ||.|| .||  |.... . . . |..|.. ||.  .||  |
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

FPRGQDNGNT
...|. .. |
Wqegsyddit
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 47-204 5.1e-06 19.5 In-house 31-167 (169) alignment 
Range on Protein: 47-204
Range on HMM: 31-167/169.0
NRYRDIHPYNHTRIRLERG----DVRYINAslieaplakrkyiltqgpltrtvchfwQMVWEQDSRAIIMLNNfvenHQQKcADYFPRGQDNGNTDELLC
||       .|||..|.|        ||||                           .|.|| ..  |..| .     ..|  ...|  .|      .. 
nrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgd....tddk.nnfwpekedyqlhpavil

EDTLLKVTYLRQERHHYYI--VRTLLLEDLVTQQTKEI-----LHFHYTRWSDFSVPQSPAAFLQFLHH
 .      |.| .. |  .  |  |.   .| .. ..        .||. | . .|||||    ...||
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhvghlfhh
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 47-204 9.3e-06 18.6 In-house 30-166 (169) alignment 
Range on Protein: 47-204
Range on HMM: 30-166/169.0
NRYRDIHPYNHTRIRLERG----DVRYINAslieaplakrkyiltqgpltrtvchfwQMVWEQDSRAIIMLNNfvenHQQKcADYFPRGQDNGNTDELLC
||       .|||..|.|        ||||                           .|.|| ..  |..| .     ..|  ...|  .|      .. 
nrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGd....tddk.nnfwpekedyqlhpavil

EDTLLKVTYLRQERHH--YYIVRTLLLEDLVT-----QQTKEILHFHYTRWSDFSVPQSPAAFLQFLHH
 .      |.| .. |     |  |.   ||      . |...  .||. | . .|||||    ...||
Gewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvghlfhh
subfamily_eak_pd Subfamily eak 51-210 4.2e-21 69.7 In-house 59-212 (332) alignment 
Range on Protein: 51-210
Range on HMM: 59-212/332.0
DIHPYNHTRIRLE---RGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPrgqDNGNtDEL-LCEDTL
.| ||..  .||    .    ||||||.| .   ||||||  .    |  ||||| || | ||..| . ||.. .|   |||   |..  .||      .
kivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp...dktr.eelkfGildv

LKVTYLRQERHHYyivRtlLLEDLVTQQTKEILHFHYTRWSDFSVPQSpAAFLQFLHHVRRSGS
 .  .....  ..   |  |||  .  .|...||...  |.....|.    || . . ..  | 
erkefvkrnilet...r..llelskGnethrvlhykvfGwtettlpky.edflalrkvmkevGv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 54-121 2.7e-06 21.7 In-house 4-66 (130) alignment 
Range on Protein: 54-121
Range on HMM: 4-66/130.0
PYNHTRIRlergDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNfVENHQ
... .|..    .  |||||..      ..|.||| ||. |  .||.|. |.    ...|   ||. .
efevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veeed
0046846 (Phosphotyrosine protein) phosphatases II 59-282 6.9e-38 125.5 In-house 4-170 (176) alignment 
Range on Protein: 59-282
Range on HMM: 4-170/176.0
RIRLERGDVRYINASLIEAPlakrKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGNtdellcedtllkvtylrqerhh
|.. ...|. ||||.||  .    ..| ||||| ||. .|..|..|.. .|...|.. || .. ||..|.|. ...|                       
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

yyivrtllledlvtqqtkeilHFHYTRWSDFSVPQSpAAFLQFLHHVRRsgSLVDNvGPPVIHCSAGVGRSGTLCLVDtcLVQIEkkgntSGLDVRKQLL
                     ..... | |..||.. ...|..|  .|.   | .. || ..|||||.||.|||.. .  |.. |      ||.| . | 
.....................qylhlpwpDhgvpdl.elllellefire..alkeg.gpvlVHCsaGigRtgtlvaay..llele.....kglsveeala

DMRRYRH-GLIQTWQQLRFSYCAIL
 .|..|. | .|| .|.|| | ..|
lvreqRplgavqtpeQyrflyefel
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 62-275 3e-28 93.4 In-house 70-271 (301) alignment 
Range on Protein: 62-275
Range on HMM: 70-271/301.0
LERGDVRYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDngntDELLCEDTLLKVTYLRQERHHYYI
.. |    | |  |...   ...| |||||. |   || |.   |   |.|| ..||....||..|.|        ..|  .   .|..   .  ..  .
ivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis....ekldigrfkikiknkelilnkkis

VRTLLLEDLVTQ-QTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvdnvgPPVIHCSAGVGRSGTLclVDTCLVQIEKKgNTSGLDVRKQLLDM
 ||| .||   . .|. ..|. |..|.|  ||.| |   .... |..|        | |.|||||.||| ..  . |  .  | . .   ... . | ..
krtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrsvaf..igteylareve.adptieltealkhl

RRYRHGLIQTWQQLR
|  |   .|| .|| 
rehrwngvqtnsqly
0044763 (Phosphotyrosine protein) phosphatases II 63-276 2.6e-26 87.8 In-house 14-162 (178) alignment 
Range on Protein: 63-276
Range on HMM: 14-162/178.0
ERGDVRYINASLIEaplaKRKYILTQGPltrtvCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDngntdellcedtllkvtylrqerhhyyiv
    ..||||| |      . |. ...|      .......|.. ..|..|.. .|....||  |.|.. .                             
glersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............................

rtllledlvtqqtkeiLHFHYTRWSDFSVPQSPAAFLQFLHHVRRS----GslvdnvGPPVIHCSAGVGRSGTLCLVDTCLVQiekkgntsGLDVRKQLL
                ...... ..|..||.... ||.|.. ...     |      || ..||||||||||||.. . ....        ||.. . . 
................iqylhipipDhgvpdllehflefvefieealdekg......gpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaie

DMRRYRHgLIQTWQQLRF
 .|..|   ...  |||.
lvrerRp.ivpnpgqlrq
0051082 (Phosphotyrosine protein) phosphatases II 67-282 7.5e-31 102.1 In-house 3-150 (151) alignment 
Range on Protein: 67-282
Range on HMM: 3-150/151.0
VRYINASLIEAPlakrkYILTQGPLTrtvcHFWQMVWEQDSRAIIMLNNFVENHqqKCADYFPRGQdngntdellcedtllkvtylrqerhhyyivrtll
. |||.| ..       .....|||     .|.....|.. ..|..|.. .|.   .|..|.|. .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ledlvtqqtKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRsgslvDNVGPPVIHCSAGVGRSGTLCLVDTCLVQiekkgntsgLDVRKQLLDMRRYRHG
          |.||.... |.|...|.|..|.|.||.....     .. || ..|||||.||.|||.... .| .         ... . | ..|..|.|
.........ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpg

LIQTWQQLRFSYCAIL
..|..|| .| ..|.|
vvqpnqqflfqlfall
0036282 (Phosphotyrosine protein) phosphatases II 68-276 1.1e-36 121.6 In-house 3-161 (174) alignment 
Range on Protein: 68-276
Range on HMM: 3-161/174.0
RYINASLIEAPLAKRKYILTQGPLTrtvchFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRgqdngntdellcedtllkvtylrqerhhyyivrtlll
.||||| .      ...|..||||.     ||.|..|.......||.. .|..  || .|.|.                                     
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

edLVTQQTKEILHFHYTRWSDFSVPQSPAaFLQFLHHVRRSGSLvDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEkkgnTSGLDVRKQLLDMRRYRHGL
  | .  ........|. | |..|| ..  .|.|.  |..  |  |. || ..||||||||.|||.. . .|....    .|  |. . .  .|..|.| 
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgm

IQTWQQLRF
.|| .|.||
vqtpsQyrf
0043147 (Phosphotyrosine protein) phosphatases II 68-278 4.1e-36 119.7 In-house 6-154 (172) alignment 
Range on Protein: 68-278
Range on HMM: 6-154/172.0
RYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFvenhqqkcadyfprgqdngntdellcedtllkvtylrqerhhyyivrtlll
 |||||... .   ...| ||||| .|. .||.|..|.. ..|..|...                                                   
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...................................................

EDLVTQQTKEILHFHYTRWSDFSVPqSPAAFLQFLHHVRRSGsLVDNVGPPVIHCSAGVGRSGTLCLVDTCLvqiekkgntSGLDVRKQLLDMRRYRHGL
. . .. ........|. | |..|| ... .|.||. ...   .... || ..||||||||.|||.. . .|          ||.. . .  .|. | | 
lydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpga

IQTWQQLRFSY
.|. .|.|| |
vqnpsqyrfly
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 68-112 2.5e-07 24.5 In-house 71-115 (347) alignment 
Range on Protein: 68-112
Range on HMM: 71-115/347.0
RYINASLIEAPLAKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIM
 ||||| |    |...||||| ||  ||  ||.||       .. 
tyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
0051429 (Phosphotyrosine protein) phosphatases II 69-284 5.5e-36 120.0 In-house 6-224 (272) alignment 
Range on Protein: 69-284
Range on HMM: 6-224/272.0
YINASLIEAPLA---KRKYILTQGPLTRTVCHFWQMvWEQDSRAIIMLNNFVENHQQKCADYFprgqdnG----------NTDELLCEDTLLKVTYLRQE
||||. .  .     ........|||. |. .||.. .|.. ..|..| . .|  ..||  |                  ....   .   | ||.|  |
yiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw......pgirylhlpilddsaptilygalrvtllsee

RHHYYIVRTLLLEDL-VTQQTKEILHFHYTRWSDFSVPQSPaaFLQFLHHVRRsgslvdnVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKGNTS-----
 ...||.|.|||. |  .... |..|.|||.| |..|||..  .|..|.....        || ..|||||..|.||..... .| ....          
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

GLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEG
 | ... .  .|..|.| .||..|..| | |.|| 
nlyleeaveelraqrpgavqteeqylflyeallel
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 69-282 2.6e-16 54.6 In-house 48-256 (290) alignment 
Range on Protein: 69-282
Range on HMM: 48-256/290.0
YINASLIEAPLAkRKYILTQGPLTRT-------VCHFWQMVWEQDSRAIIMLNNFVENHQQ----KCADYFPRGQDngntDELLCEDTLLKVtyLRQERH
|| |. .  |    . |||| |....       . .|| |. .  .. ..|| .| |....     || |.|   .    .||  ..  .|     .| .
yiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg....eelkfkgltvkC..kskeke

HYYIVRTLLLEdLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvdnvgPPVIHCSAGVGRSGTLCLVDTCLVQIE-KKGNTSGLDVRKQ
   ..|.|...    ..   . |  .  |.. .|....  .|. ...|. |..      | ..||  |. || .|  ..     |  ..|...  || |.
ddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt......pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlka

LldmRRYRHGLIQTWQQLRFSYCAIL
|   |. |  .|.. ..| |   .|.
l...rkqralaitsalelafvdagiv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 69-138 2e-07 24.7 In-house 92-163 (349) alignment 
Range on Protein: 69-138
Range on HMM: 92-163/349.0
YINASLIEAPL--AKRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGNTD
||||  .. .   ...||| || ||  ||  |....  .  . .. ||.  |.  .||  |.  .. .. | 
yinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitv
0049260 (Phosphotyrosine protein) phosphatases II 81-278 2.4e-33 110.3 In-house 8-143 (152) alignment 
Range on Protein: 81-278
Range on HMM: 8-143/152.0
KRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFprgqdngntdellcedtllkvtylrqerhhyyivrtllledlvtqqtkeilH
....| ||||.  |. .||.|..|.. ..|.||....|..  ||. |.                                                   .
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...................................................q

FHYTRWSDFSVPQSPAAFLQFLHHVRRSgsLVDNVGPPVIHCSAGVGRSGTLCLVDTCLvqiekkgntSGLDVRKQLLDMRRYRHGLIQTWQQLRFSY
.... | |..||...  .|..|. ...   . |. || ..||||||||.|||.. . .|          |... . .  .|. | | ... .|||| |
ylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 81-283 1.6e-24 81.4 In-house 34-219 (255) alignment 
Range on Protein: 81-283
Range on HMM: 34-219/255.0
KRKYILtqgpltrTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNgntdELLCEDTLLKVTYlrqeRHHYYIVRTLLLEDLVT--QQTKEI
|  |.|       || .|.|..  ...  ..|| .| |. ..||  |||  .|.     |  .|  . .|          ..||| .   ..  ..|...
knlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekde....klkladvnvtttk....ssadvvlrtleitstlgekkkthtv

LHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLvdnvgppVIHCSAGVGRSGTLCLVDTCLV---QIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLR
 |..|. | .   |. .   |. |. || | |.       |.|||.|.||| .. |..       .  .. .| .|| .. | ..|  |.. |.|  || 
khysykGWieknaPelareilnilkvvrdsksv.......vvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqla

FSYCAILE
||   .|.
fsilmvld
subfamily_hpo-7_pd Subfamily hpo-7 81-283 4.9e-22 73.1 In-house 37-225 (263) alignment 
Range on Protein: 81-283
Range on HMM: 37-225/263.0
KRKYILtqgpLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNgntdELLCEDtllkVTYLRQERHHYYIVRTLLLEDLVT--QQTKEI
|  |.|    | .|.  |.|..  . .  ..|| .| |. ..||  |||  .|.     .  ..    |.    .  .  ...|| |   .   ..|...
knlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekde....kqklan....vnvcttkvqsdvllktlellstlgeKkkthtv

LHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLvdnvgppVIHCSAGVGRSGTLCLVDTCLV---QIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLR
 |. |. | .   |. .   |. |. .| | ||       |.|||.|.|||    ....      .  .. .| .|| .. | ..|  |.. |.|  || 
khysykgWiekndpelareilnilkvarnsksl.......vvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLa

FSYCAILE
||   .|.
fsilmvLd
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 81-278 4.5e-21 69.9 In-house 3-196 (198) alignment 
Range on Protein: 81-278
Range on HMM: 3-196/198.0
KRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDnGnTDELlcedTLLKVTYLRQERHHYYIVRTLLLEDLVT--QQTKEI
.|.|| || ||  |.. |||||||  |  |.|.|.   |..   . |.|  .  | | .     . | ||      .  | . .|.| . .|    |.||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes.g.tgky....gslsvttktittkpdytitaliltnnttappstrei

LHFHYTRWSDFSVPQSpAAFLQFLHHVRRSGSLVD--NVGPPVIHCSAGVGRSGTLCLVDTClVQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRF
 |. .| | . . |.  | |. |.   |      .  .  | ..||| | | .| .  .|   |.  .. .|| .|. .    .|. | |.| . |.  |
shyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldig.vrsheesktsvvdlfevakrlrqarcgiisslqhynf

SY
 |
iy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 81-278 4.7e-21 69.9 In-house 4-197 (199) alignment 
Range on Protein: 81-278
Range on HMM: 4-197/199.0
KRKYILTQGPLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDnGnTDELlcedTLLKVTYLRQERHHYYIVRTLLLEDLVT--QQTKEI
.|.|| || ||  |.. |||||||  |  |.|.|.   |..   . |.|  .  | | .     . | ||      .  | . .|.| . .|    |.||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes.g.tgky....gslsvttktittkpdytitaliltnnttappstrei

LHFHYTRWSDFSVPQSpAAFLQFLHHVRRSGSLVD--NVGPPVIHCSAGVGRSGTLCLVDTClVQIEKKGNTSGLDVRKQLLDMRRYRHGLIQTWQQLRF
 |. .| | . . |.  | |. |.   |      .  .  | ..||| | | .| .  .|   |.  .. .|| .|. .    .|. | |.| . |.  |
shyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldig.vrsheesktsvvdlfevakrlrqarcgiisslqhynf

SY
 |
iy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 90-278 2.7e-15 50.6 In-house 99-281 (302) alignment 
Range on Protein: 90-278
Range on HMM: 99-281/302.0
PLTRTVCHFWQMVWEQDSRAIIMLNNFVENHQQKCADYFPRGQDNGNTDELLCEDTLLKVTYLRQE-RHHYYIVRTLLLE--DLVTQQTKEILHFHYTRW
|   |.  .| .. . .   .. | .|||....|||.|.    ..  .    .  |.   | | .    . . . |. ..     ... | .  .... |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

SDFSVPQSPAAFLQFLHHVrrsGSLVDNVgppVIHCSAGVGRSGTLCLVDTCLVQIEKKgNTSglDVRKQLLDMRRYRHGLIQTWQQLRFSY
 |   |. . . |. |..     |   ||   ..||||||||.|||  .   .    || ...  |. . .| .|. |.| .|. ||| .  
pdhGapkeaytaldilkfc...esykknv...lvhcsaGvGrtGtlvaikyGiqlcskk.kvt..dllsivlpvrqcryGavqdeqqliyll
0048179 (Phosphotyrosine protein) phosphatases II 151-276 2.4e-21 71.4 In-house 22-136 (144) alignment 
Range on Protein: 151-276
Range on HMM: 22-136/144.0
YLRQERHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvDNvGPPVIHCSAGVGRSGTLCLVDTCLvqiekkgnTSG
. .  ... . | .|  |   .  ..|....... | |..||.... .|.||. ...  .  .. || ..||||||||.|||.. . ..        . |
lellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eg.gpvlVHCsaGvgRtgtlvaaylmk........klg

LDVRKQLLDMRRYRHGLIQTWQQLRF
|.. . |  .|..| | .....||||
lsleealalvrsrrpgavpnpgqlrf
0048076 (Phosphotyrosine protein) phosphatases II 156-279 2.3e-20 68.2 In-house 25-137 (145) alignment 
Range on Protein: 156-279
Range on HMM: 25-137/145.0
RHHYYIVRTLLLEDLVTQQTKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSlvDNvGPPVIHCSAGVGRSGTLCLVDTCLVqiekkgntSGLDVRK
 ... | . | | .  .  ........|. | |..||.... .|.||. ...  .  .. || ..||||||||.|||.. . .|          |... .
lkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealk..eg.gpvlVHCsaGvgRtgtlvaaylmll........lgvslee

QLLDMRRYRHGLIQTWQQLRFSYC
 |  .|..|.| ... .|||| | 
alelvrsqrpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 175-308 1.6e-13 44.8 In-house 88-213 (440) alignment 
Range on Protein: 175-308
Range on HMM: 88-213/440.0
TKEILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNvGPPVIHCSAGVGRSGTLCLVDTCLVQIEKkgnTSGLDVRKQLLDMRRYRHGLIQTWQQL
.. . ..||  | | .||.  .  |.... |  |   . | || ..|||||.||.| .  ||. | . ..   .  .|.   .  ||  |  ..|| .| 
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagn.gpllvhcsagagrtgviiavdsilreakr...sdqidifsfinsmrnnrpqmvqtpeqy

RFSYCAILEGskvILRGDDLgSLTVENNTDVESI
 | . |.|||   .| || |  |  .    || |
afvheavleg...llcgdtl.iledditerveqi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 176-264 1.6e-07 25.0 In-house 218-315 (349) alignment 
Range on Protein: 176-264
Range on HMM: 218-315/349.0
KEILHFHYTRWSDFSVPQSPAAFLQFLHhVR---------RSGSLVDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKGNT-SGLDVRKQLLDMRRYR
 |.| . .  | | |.   | ..|| |. |.         |     |.. . ..||||| ||.|.|. .|  |  .|   |    .... .| |.  . 
yellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisii
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 177-246 1.1e-10 35.8 In-house 216-293 (350) alignment 
Range on Protein: 177-246
Range on HMM: 216-293/350.0
EILHFHYTRWSDFSVPQSPAAFLQFLH--------HVRRSGSLVDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKG
.......  | | |.   |  .|| |          . .| .  ..  | ..|||||||| |||. .|  | ..|   
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeile
PTPc_DSPc_SM00012 178-283 6.7e-28 92.3 In-house 2-105 (105) alignment 
Range on Protein: 178-283
Range on HMM: 2-105/105.0
ILHFHYTRWSDFSVPQSPAAFLQFLHHVRRSGSLVDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKGntSGLDVRKQLLDMRRYRHGLIQTWQQLRFS
. |.||| |.|..||... ..|..|..|... .  .. .| |.||||||||.||....|..| |.||.   . .|. . .  .|..|.|..|| .|  | 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfl

YCAILE
| |.||
yralle
subfamily_CG42327_pd Subfamily CG42327 212-287 2.2e-09 31.4 In-house 244-317 (319) alignment 
Range on Protein: 212-287
Range on HMM: 244-317/319.0
VDNVGPPVIHCSAGVGRSGTLCLVDTCLVQIEKKGNTsgLDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILEGSKV
 .. || |.||| ||||.|..   |  . ..|.  ..  .|. . .  .|| |   ..| .|  | |  . | .| 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrs..vdiPqlvssvrrdrasavltkeqyefiykvlseyakk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 219-283 4.5e-09 30.6 In-house 232-293 (297) alignment 
Range on Protein: 219-283
Range on HMM: 232-293/297.0
VIHCSAGVGRSGTLCLVDTCLvQIEKKGNTSglDVRKQLLDMRRYRHGLIQTWQQLRFSYCAILE
..|||||||||| . | |. | .. .|.     ||.  |  .|  |  |.|| .|  . | |.|.
lvhcsaGvGrsGvvvlsdvil.aklrkkrip..dvaailsilreqrarlvqtleqfellydavlk