Gene PTPN12 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP056_AA protein Get Run
SpurP056_AA_12-297 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051299 (Phosphotyrosine protein) phosphatases II 6-295 1e-88 292.8 In-house 6-285 (288) alignment 
Range on Protein: 6-295
Range on HMM: 6-285/288.0
NLENFLEHYENMAdlsssLDGSDSFELEFNHLKQISQRyrtekvYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTY
..|..|......      ..|   .. ||..| ..         ...||.    |. ||||.||||.||||  || .|.||||||.||....|  .....
sveellklvlkll.....angltglleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkf

LAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDeGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT------RDKEEKIFNQFHYTAW
.|.|||||.||..||||.|| |...||| ....|||| ||..|| . |.  ..||| || .  .   .|...|||. |       |.|... ..||||.|
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnw

PDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
||||||.|....||...|||... . ..|.|||||||.|||||....|.. . |. |   . .......  .|.||. .||| .||..|..|... 
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_PTPRB_pd Subfamily PTPRB 6-298 3e-85 280.8 In-house 8-287 (293) alignment 
Range on Protein: 6-298
Range on HMM: 8-287/293.0
NLENFLEHYENMADlssslDGSDSFELEFNHLKQISQRYRtekvypTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTY
.||.| ||...|.      |    |  |...||.. .         ..| |. ||  ||||..|||.||||  |..... .||||.|||...|    . .
klekfeehvkkmka.....dsdlrfseeyeelkavgkdqa......vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspref

LAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQQrVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVP
.|.|||||.||..||||.|| ...||||  . .| |. |||.|| .. |.. .||| || . .. ...|..||.|| ...|||.  .|.|.|.|||||||
iatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaee.eledwvirelkiekekeerkvrqyhftsWpdhgvP

TSVKPILDMIKLVREYQ--TAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
 . |..||... |||..  ||.. ||||||||| |||||   .| . .|..    ..   .. |....|..|  .||| .||  .|..|.|... 
ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 9-298 8.5e-83 273.0 In-house 6-282 (318) alignment 
Range on Protein: 9-298
Range on HMM: 6-282/318.0
NFLEHYENMADlssslDGSDSFELEFNHLKQISQryrteKVYPTSAgESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAA
.. .| ...       .|.  .. |...|.. ..     .|  . .  ..|| .|||| .||..||.| .|......|||||.|||.. |  ....|.||
dleshvrrlre.....sGelllseeyerlsrsee.....tvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaa

QGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEhCFGDILVTQIGQqRVTKDFMIRTLKATRDK--EEKIFNQFHYTAWPDHGVPT
|.|||.|...||||.|| |. .|||  .| | |..|..||| ..| .  .|.. |.   .   ..|...|..| ||..  |...  |.|||.|||.|||.
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsr.sygklvvelkee.velsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpe

SVKPILDMIKLVREYQ-TAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
|.  .||... |...| .... ||||||||| ||||. ...| . . .. |..     .....  .|.|| ..|||..|||... ..... ..
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiydvllealas
0050432 (Phosphotyrosine protein) phosphatases II 10-300 1e-87 289.6 In-house 24-303 (308) alignment 
Range on Protein: 10-300
Range on HMM: 24-303/308.0
FLEHYENMADLSSSLDGSDSFELEFNHLKQISQryrtekVYPTSAGESDVNMRKNRYKDILPFDHSRYLLsqidNvEGSDYVNANFLKGA--ANDHTYLA
.  ...... |  .....  .| ||..| ..        ....|...   |. |||||||||.||||  |    . |||||.||.. .|    ......|
lklsvldllkllekaldlglleeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIa

AQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDE--GEEHCFGDILVTQIGQQRvTKDFMIRTLKATR--DKEEKIFNQFHYTAWPDHG
.|||||.||. ||||.|| |...||| ....| || ||..|| .|  |.  ..|.. || . ..   .|...|||. |   |.|... ..||||.|||||
tqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhg

VPTSVKPILDMIKLVREYQtaEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHL
||.|....||...|||...  ...|||||||||.|||||....|.. . |. |   .........  .|.||.  ||| .||....||...... .|
vPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 13-298 3.5e-72 238.1 In-house 13-285 (319) alignment 
Range on Protein: 13-298
Range on HMM: 13-285/319.0
HYENMADlssslDGSDSFELEFNHLKQISQRyrtekvyPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPL
.....|.      |. ..| ||..||. ..         ..  . . | .||||..||..|..|  ||..|.||||||.||.|. |  . . ..|.|.||
rlkalas.....tgetllekefkllkeavnd.......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPl

PHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWvDEGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT---RDKEEKIFNQFHYTAWPDHGVPTSVK
 .|...||||.|| .. |.|| ..  | .. |...|| .| . . .| ..||   ... ..|..|| ||      . | .   .|.||.||||.||.. .
entiedfWrmvWeeessivvmltklveklkvklkkyw.peenfeeyGrlivtleeeee.ledyiirklklnkkssevetRevkhfqyteWpdhdvPekat

PILDMIKLVREYQTA-EEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
 .||..| .|. .   .. ||||||||| ||||| .|.| . . ...|   .   .. ..  .| ||  .||. .||.... |.... .|
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkee...gvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 13-316 9.4e-62 204.1 In-house 19-312 (319) alignment 
Range on Protein: 13-316
Range on HMM: 19-312/319.0
HYENMADLSSSLDGSDSFELEFNHLKQISQRYRTeKVYptsaGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPL
.| ...  |   |    .| ||... ...    . . .     . | |  |||. .||.||...  | ... .|.|||.|| |..|  .   |.||||||
yyqqlsnksdfdddltklevefrracklgvnlad.qtf....anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

PHTVNEFWRMLWECNTEIIVMACnefelgRHKCERYWVDEGEEH-CFGDILVTQIGQqrvTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSV
. |...||||.|| |.  ||.        ..|| .||  .....   ... |. . .   |.....| .. ..    |. .  .|||.  |||.||| . 
dntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsvee...taeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp

KPILDMIKLVREYQTAE--EPPIVVHCSAGCGRTGTICVIDYVRNALQLEKidqNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD-MFQAHLGIKPE
 ... ..| ||  .. |  . .||||||||.||||.  |.| . . .. ||      .|... |.|.||  .||   || ... |...  . .|  .   
sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeek...qvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvamp

DYGHNYENVQL
|.   .|.   
dfpayleelsn
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 15-297 2.9e-71 235.2 In-house 15-291 (298) alignment 
Range on Protein: 15-297
Range on HMM: 15-291/298.0
ENMADLSSSLDgSDSFELEFNHLKQISQRYRTEKvypTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPH
...|. . . .    ..|||..|...|.. ..|.   ....... | .|||| ||...|.|| .|...|. | |||.|| ||... . ....|.|.||..
qklaavkkkkk.ltgyalefqrlnsvsseieeee...kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlte

TVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHcFGDILVTqIGQQRVTKDFMIRTLKATRDK--EEKIFNQFHYTAWPDHGVPTSVKPIL
||..||||..| . . |||  |  ||.. |...|| |||.|. .|.| |. . .. .  |...|.|| .. |  .|.   |.|.| |||.|||.  . .|
tvedFWrmvteedigtiVmltnleeldktkyhkywPdegket.ygeitvs.llskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvl

DMIKLVREYQTA-EEPPIVVHCSAGCGRTGTICVIDYVrnaLQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
|... || .|.   . |..|.|||| ||.|| ..|| |   |.  |..|   .....  .||.| ..|||..||  .. || ....
dllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsv...lervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPN23_pd Subfamily PTPN23 22-295 1.3e-54 180.0 In-house 9-279 (288) alignment 
Range on Protein: 22-295
Range on HMM: 9-279/288.0
SSLDGSDSFELEFNHLKQISQRYrtekVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSqidnVEGSDYVNANFLKGAA-NDHTYLAAQGPLPHTVNEFW
. |||  ... .|. |.|  ..        .|   . ..  |||..||||.||.|  |      .  ||.|| |.|. .    ...|.|.||. |.|.||
kmldgktaldkkfkeleqkqdke....arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFW

RMLWECNTEIIVMACNEFELGRHKCERYW-VDEGEEHCFGDILVTqIGQQRVTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKL
.|..|  ...|||  .. |||..|..|||  |.|| . |||. || . ..| |. .. |.|| .  . .. |     ..|.||..||| | . .|.... 
lmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvt.lksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

VRE-YQTA---EEPPIVVHCSAGCGRTGTICVIDYVRNALqlEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
|.. |..     . |.||||||| ||||.....  . ..|  || .    . ...  .|.||.  ||...|.. .  ||.  
vesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel..ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN12_pd Subfamily PTPN12 23-308 1.7e-141 465.3 In-house 3-289 (290) alignment 
Range on Protein: 23-308
Range on HMM: 3-289/290.0
SLDGSDSFELEFNHLKQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRM
. .|...|. ||..||..|..|..||||.|.|||...|..|||||||||.|.||. ||.|...|||||.||||.||......|.|||||||.|...||||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

LWECNTEIIVMACNEFELGRHKCERYWVDEGEEHC-FGDILVTQIGQQRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREY
.||.|.||.||||.|.|||..||||||..||||.. ||.. ||.. ...|..||.|||||....||.....|||||||||||||.|.|..|..|.||||.
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrel

QTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLGIKPEDYG
|..|. |.|||||||.||||||..|||||..|. |||.......|.....||||.|.|||..|||||..||....|..|.|..|...
qesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiieekks
0047943 (Phosphotyrosine protein) phosphatases II 23-294 1.8e-83 275.5 In-house 7-270 (273) alignment 
Range on Protein: 23-294
Range on HMM: 7-270/273.0
SLDGSDSFELEFNHLKQISQryrtekVYPTSAGESDVNMRKNRYKDILPFDHSRYLLsqidNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRM
.|.|.. ...||..|...        ....|...   |. |||||||||.||||  |    . .||||.||....|    ....|.|||||.||..||||
kllgltllleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

LWECNTEIIVMACNEFELGRHKCERYWVDEGE--EHCFGDILVTQIGQQRvTKDFMIRTLKATR--DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLV
.|| |...||| ....|||| ||..|| .||.  .  .|.. || ....   .|...|||. |.  ..|... ..|||| |||||||.|....|..|.||
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

REYQTA--EEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
|... |  ...|.|||||||.|||||....|.. . |. |   .........  .|.||. .||| .||.....|...
rkalealpsngpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 23-294 2.3e-83 275.7 In-house 22-302 (307) alignment 
Range on Protein: 23-294
Range on HMM: 22-302/307.0
SLDGSDSFELEFNHLKQISQRYrtekVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNV-EGSDYVNANFL--------KGAANDHTYLAAQGPLP
 ||.   .. ||..|...  ..    ....|.... .|. |||||||||.||.|  || .|.  |.|||.||..         .|  ......|.|||||
lldfltgllkefekllsvtvfl....lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlp

HTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT---RDKEEKIFNQFHYTAWPDHGVPTSVKP
.||..||||||| ....||| ....|||| || .|| ||||| ..|.. || .. .   ... .|||. |    ..|. . ..||||.|||||||.|...
etvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

ILDMIKLVREYQTA--EEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
.||.|..||... .  .. |..||||||.|||||.......   |. |.. ....|....  .|.||. .||. .||. ...|. .
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 23-299 5.2e-83 274.2 In-house 27-292 (297) alignment 
Range on Protein: 23-299
Range on HMM: 27-292/297.0
SLDGSDSFELEFNHLKQISQryrtekvyPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNV-EGSDYVNANFLKGAAN-DHTYLAAQGPLPHTVNEFW
 ....  ..||| .|...          ..| ... .|. |||||||||.||||  |. .|.| ..|||.||....|    .....|.|||||.||. ||
kansktllllefeellslkp........dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFw

RMLWECNTEIIVMACNEFELGRhKCERYWVDEGEehCFGDILVTQIGQQRvTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVRE
||.|| ....||| ....|||| ||..|| .||.  ..||. || .. .   .....|||. |...|... ..|.|| ||||||| |.. .|....||||
rmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvre

YQTA--EEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAH
.. .  .. |..||||||.|||||....... . |. |   .........  .|.||. .||| .||. ...|...... .
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 24-297 4e-76 250.8 In-house 17-280 (288) alignment 
Range on Protein: 24-297
Range on HMM: 17-280/288.0
LDGSDSFELEFNHLkqisqrYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRML
 .. . |. |.| |         ||   ..||.  || .||||..|||.|. |  | . ....|.||.||....|  ....|.|.||||..|||.||.. 
arnrtgfseeynsL......aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQQRvTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQT
.| .|. |||  .  | |..|||.|| |..... .|.. || ....  ..||. |.|   ..|.|   .|..|.|||||||| | .|.|.... |   ..
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveske.ledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

AEEPPIVVHCSAGCGRTGTICVIDYVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
|.  ||.|||||| |||||  ..| . .|..    ..   . ...  .||||  .||| .||| ........ .
adtgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 24-296 1.1e-53 176.9 In-house 16-283 (290) alignment 
Range on Protein: 24-296
Range on HMM: 16-283/290.0
LDGSDSFELEFNHLKQisqryrTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEG--SDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWR
  | ..|. .|. |..      .|. . .  | .  | ..||...|.. |  |  | .| . .    .|.|| ..||  ... |.|.|||...|. .||.
akgnegfrnqfkmlds......gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWk

MLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHcFGDILVTQIGQQRVTkDFMIRTLKATRDKE---EKIFNQFHYTAWPDHGVPTSVKPILDMIKLV
..|. .. |||| .|. | |..||  || |.. .. .| . .. . .. .. ....|.|. . ...   ...  |.. |.|...|  |  . || .|. .
liwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieem

RE-YQTAEEPPIVVHCSAGCGRTGTICVIDyvrNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
 .      . .||||||.. ||... |...   ....  |...   .....  .| |.   ||| .||..... |.  .
yktqrkrgntsivvHCSdtvgrsavfcaaa...ttinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPN6_pd Subfamily PTPN6 25-296 6.5e-79 260.1 In-house 23-297 (306) alignment 
Range on Protein: 25-296
Range on HMM: 23-297/306.0
DGSDSFELEFNHLKQISqryrTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSqIDNVEGSDYVNANFLKGAAN--DHTYLAAQGPLPHTVNEFWRM
 .   || ||..|.|      ..|..  . |.   |..||||| ||||||.|  |.  ..| ||||.|||..|....  |..|.|.|| |..||..||||
lekagfeeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

LWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQqRVTKDFMIRTLKAT---RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVR
.|. |...|||. .| | |..|| ||| || |.. .|.| ||.. . . ..|...|.|. .   ..|||.   |.|...|||||||.. . .||... |.
vwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

EYQTAE----EPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
. |       . ||||||||| |||||. ||| . . .. ...| .. .....  .|.||  .||| .|| .|..|.    
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPRA_pd Subfamily PTPRA 25-296 9.1e-73 240.0 In-house 29-295 (330) alignment 
Range on Protein: 25-296
Range on HMM: 29-295/330.0
DGSDSFELEFNHLKQISQRYRTEkvyptsAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLW
| .  |  ||| |   . .   |      . . . |..|||. .|||.|.||  ||... || |||.|| |..|  . ....|||||. .||..||||.|
ddnklfreefnalPagpiqatle......laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiw

ECNTEIIVMACNEFELGRHKCERYWVDEGEeHCFGDILVtQIGQQRVTKDFMIRTLK------ATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLV
| ..  |||  .  |  ..||..|| |||    .|.| | .. .. |..|. .| .       |||.|.... .|||.|.||| |||.  . .|...| |
eqksativmltelkerkeekcaqywPdeGl.vtyGnirv.evedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkv

REYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
.. .  .  ||||||||| ||||| .|.| | . .   | ..   .....  .|.||  .||| .|||...... . .
kklnqqsagpivvhcsaGvGrtGtfivldavlerv...kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPRG_pd Subfamily PTPRG 25-298 8.5e-69 227.2 In-house 16-289 (563) alignment 
Range on Protein: 25-298
Range on HMM: 16-289/563.0
DGSDSFELEFNhlkQISQRYrTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGS-DYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRML
||   |. ||.   .. ..  ..|  .... .   | ||||| .|...|.||  ||.. ..... ||.|||...|    . ..|.||||..|.. ||||.
dgdigfseefe...alqset.iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmi

WECNTEIIVMACNEFELGRHKCERYWVDEGEEHcFGDILVTQIGQQRV----TKDFMIRT--LKATRD-KEEKIFNQFHYTAWPDHGVPTSVKPILDMIK
|| |..||||  |  | ||.||..||  .. |. .| . ||.| ....    .. ..|.   ||.... ..||   |.||| |||||||..  | | ..|
WeqnvaiivmitnlvergrrkcdvYWPkdeset.ygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk

LVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
     . ||  ||||||||| ||||| .|.| . . .| |..     .....  .| ||  .|||..||  .| |.... ..
kssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqena...vnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 25-296 3.3e-51 169.0 In-house 17-278 (287) alignment 
Range on Protein: 25-296
Range on HMM: 17-278/287.0
DGSDSFELEFNHLKQISQRyrTEKVyptSAGESDVNMRKNRYKDILPFDHSRYLLSqidnVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLW
 |.. |.  |  |.|..||   ..|     . .  |  |||...||. |  | ||      |  ||.|| |..|  ... ...|..|. .|. .||....
kgnegfknqftvleqvtqr..edev...thniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWklid

ECNTEIIVMACNEFELGRHKCERYWVDEGEeHCFGDILVTQIGQQrVTKDFMIRTLKATRDK---EEKIFNQFHYTAWPDHG-VPTSVKPILDMIKLVRE
. | ..||| |.| |  ...| .|| .|    ..|.  .. . .. |......|.|. ....   ...  .|...|.|...| |..    .| . . ...
drnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt

YQTAEEPPIVVHCSAGCGRTGTICVIDYvrnALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
 .   . .||||||.. ||... | ..    ...  | .    .....  .| |.   ||| .||. .  .|. . 
qrkrgntsivvhCsdtvGrsamfcaaat...tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 26-297 5.3e-42 138.5 In-house 22-290 (305) alignment 
Range on Protein: 26-297
Range on HMM: 22-290/305.0
GSDSFELEFNHLKQISQRYRTEKVYPTsAGESDVNMRKNRYKDILPFDHSRYLLsqiDNVEGSDYVNANFLKGA-ANDHTYLAAQGPLPHTVNEFWRMLW
| | .  || .| . ..   |.... .    .|... ||||.|.   |.|  .|   |.   |||. ||..      .. ...||||| .|..||| |. 
gvdklreefrglakytrpdmtqvafna.nqsadiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmvi

ECNTEIIVMACNEFELGRHKCERYWV-DEGEEHCF-GDILVTQI-GQQRVTKDF--MIRTLKATRDKEEKI-FNQFHYTAWPDHGVPTSVKPILDMIKLV
. . | ||| |.  |||. || .||    || . . . |.| .. | . . .|    | .|. |   ..|.   ....| ||| |||      |...  .
qnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai

REYQTaeepPIVVHCSAGCGRTGTICVIDYVRNALQLEKidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
|  .     ||||||||| ||||||  |.|. . .  .|  .   . ...  .| ||   .|.  ||  .|| ... | 
rgskv....pivvhcsagigrtgtivaieyilekiaenk..pcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 27-294 9.4e-52 170.9 In-house 19-277 (439) alignment 
Range on Protein: 27-294
Range on HMM: 19-277/439.0
SDSFELEFNHLKQISQRYRTEKVYptSAgeSDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWEC
 . |. .|.... .|  |. .      |   . .  ||||||. .|||.|  | .|  |  | |.|||..||  .|. |.|.|||  .|...|||...| 
qeifkeifekinstspdyaciasl..aa..qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviek

NTEIIVMACNEFELGRhkcerYWVDEGeEHCFGDILVTqIGQQRVTKDFMIRTLKAT--RD--KEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQ
.|  ||| .| .|  .     ||  .. | |.||| |  . ..    ...|| .|    ||  . |.   ||||.||||. ||.    .||... .   .
ktvtivmltnlvesyk.....ywpsda.evcygdiavr.vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan

TA-EEPPIVVHCSAGCGRTGTICVIDYVRNALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
   |  |.||||||| ||||||  .|   . |   |....  .  |.  .||||. .||.  || ... ||..
dkeeygpvvvhcsagvGrtGtiialdialeql...klenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 27-298 7.7e-34 111.9 In-house 5-261 (267) alignment 
Range on Protein: 27-298
Range on HMM: 5-261/267.0
SDSFELEFNHLKQISQRYRTEKVYptsAGeSDvNMRKNRYKDILPFDHSRYLLSQIDNVegsdYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWEC
  ..| ||. .|.||.   |   .    . .. |  .||. | ||.|..|  |.. ..     |.|| ...|    ..... |.||  |. .|. .. . 
eceiekefelikkisdtsstisqs...ia.ek.nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdq

NTEIIVMACNEFElgrHKCERYWVDE-GEEHCFGDILVTQiGQQRVTKDFMIRTLKAtRDKEEKIFNQ--FHYTAWpdhGVPTSVKPILDMIK--LVREY
.  .||.  . |.    .  ..|  . |. . . |. | .   ..  .|. | ||.  . |.|  .|   ..|  |    . |  || |  .   | .. 
kvpvivlltkvft...dnirlfwPPkmgqakkyqdltveh.slekeendyqiitlel.kfknesahnvtlyyykkw...nintnnkpylkplfgilaknq

QTAEEPPIVVHCSAGCGRTGTICVIDyvrNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
    ..|.||.||.| ||.||  |||     |.  | ..   ..| .  .|.|| ..|.|...|  .|. ...  . 
lengnrPlvvacsdGvGrsGtflvid...sqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg
subfamily_PTPRD_pd Subfamily PTPRD 29-318 1.5e-88 292.8 In-house 24-304 (564) alignment 
Range on Protein: 29-318
Range on HMM: 24-304/564.0
SFELEFNHLKQIsqryrteKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNT
.|| |......        .  ...| . ..| .||||..|...||||  ||.....|||||.||.|..|  ....|.|.||||..|...||||.|| |.
kfeeeykkieeg.......qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqns

EIIVMACNEFELGRHKCERYWVDEGeEHCFGDILVTqIGQQRVTKDFMIRTLKA--TRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEE
..|||  .  | |..||..|| ..| .  .|.. || . ..   .|..|||.|   ....| .  .|||.|.|||||||.| ...||.|. ||.... ..
stiVmltkleEkgkvkchkYWPekg.tetygeltVt.leeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepda

PPIVVHCSAGCGRTGTICVIDYVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAH-LGIKPEDYGHNYENVQLKH
 ||||||||| ||||| .|||.. . ..    ...  .| ..  .|||| |.|||..||  .|.|.... ..    .. |.. .. .... ..
gPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeve
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 29-294 5.3e-42 138.6 In-house 7-264 (283) alignment 
Range on Protein: 29-294
Range on HMM: 7-264/283.0
SFELEFNHLKQISQRYrtekvYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNvegsDYVNANFLK---GAANDHTYLAAQGPLPHTVNEFWRMLWE
...| .. ||..|         ..    .| | ||||...|.| |  |  |    .    ||.|| |.       .|. |..||.|| .|| .||.|...
nnklfrevlkrlsvpd.....ldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfd

CNTEIIVMACNEFELGRHKCERYWVDEGEEHcFGDILVTqIGQQRVTKDFMIRTLKATRD---KEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQ
 .   |||  .  |  | || .||  .| |  .|.  || . ..   . |.|. |    .   |.. .   . .  | . |  . .  .. . |..   .
ekitaivmltklqedlrikCsqyWPkrGsed.yGeftvt.lrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqt

TAEEPPIVVHCSAGCGRTGTICVIDY-VRNALQLEKIDqnfsLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
  .. |||||||.| |||.. . .   | .||    .|    .. ..  ||.||  .|||..|| ||| .|..
eskkgPivvhCstgiGrtavfiaasasvkdaltesvvd....vfavvkimreqrmmavqtldqyklvhelvle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 30-299 4.7e-73 240.7 In-house 17-279 (281) alignment 
Range on Protein: 30-299
Range on HMM: 17-279/281.0
FELEFNHLKQISQRyrtekvYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTE
|  |...|..| ..       ...| ..| |. ||||..|  .|..|  ... .. . .||.||||..|  ... |.|.|||.|.....||.|.|| . .
fieeyeklaaigvd......ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

IIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQqRVTKDFMIRTLKA-TRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEE-P
.|||  .| | |. || ||| |. .|  .||. |... . . .. .. |..|  ... |..  .|..||||||||||.. | .|.  | |..... ..  
aivmvtreieagklkChrYWPddnselkygdvtvkstae.eekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktka

PIVVHCSAGCGRTGTICVIDYVRNALQleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAH
|.|.||||| |||||   .| . .|..  .  .. .. ... ..||.|  .|||  ||| |..||.|... .
plvihCsaGvGrtGtyialDrlvkave..aeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_Ptp69D_pd Subfamily Ptp69D 30-297 2.6e-71 235.2 In-house 24-287 (307) alignment 
Range on Protein: 30-297
Range on HMM: 24-287/307.0
FELEFNHLKQIsqryrtEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTE
.. |...|..       |    |...| . |  ||||.|| .||. |  |..|   | |||.||.|.||  . ....|||.|.  |...||||..| . .
lakeyekLear......eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevt

IIVMACNEFELGRHKCERYWVDEgEEHCFGDILVTQIgQQRVTKDFMIRTLKATRDKE-------EKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQ
.|||  |. |  |.||..|| .| .|  .|||||. . ... ..|..||.|. .. ||       ..   |.|||.|.|  || . . .|..|. ||| .
livmlsnlteknrkkcakYWpie.devqygdilvklv.seekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrely

TAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
  .. ||||||||| ||.|..  .| . . |..|   .. ...... |.|.||  .||  .||. ..||..|. .
klnrsPivvhCsaGvgrsgifvaldsllqqlkae...dkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 30-297 7.8e-52 170.8 In-house 12-278 (287) alignment 
Range on Protein: 30-297
Range on HMM: 12-278/287.0
FELEFNHLKQISqRYRTeKVYptSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNvEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTE
 . |.. ||. | .  |  ..   | |   ...|||| |.||.|..| |||.  .  ||||.|||.. .  .|....|||||.. ||..|||...| .. 
vdkevdalkeds.esst.atf..kaaeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsa

IIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQQRVTKDFMIRTLKAT-RDKEE-KIFNQFHYTAWPDHGVPTS----VKPILDM---IKLVRe
 ...   | | .| || .|| .       |   |. . ..    .. .|.|.    . .| .. .|... .|||.... .    .. .||.   |.| | 
svitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielar.

yQTAEEPPIVVHCSAGCGRTGTICV-IDYVRNALQLEKIDQNfslyDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
 ...|  |.|||...| ||.|..   .  |.  ..| ..|       ... .|..| |.||.  |. |.  |.|  ..
.dasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdva....avvirlreyraalvqavvqlrllyealvtyyk
subfamily_CG7180_pd Subfamily CG7180 30-292 5.9e-47 154.7 In-house 15-286 (296) alignment 
Range on Protein: 30-292
Range on HMM: 15-286/296.0
FELEFNHLKQISQRYRTEKVyptSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTE
|..|.. . .. .| ....     .|    |. |||. ...|.|. | .|...|  | |||.|| .  .   .. |.  ..|  .||.||||.... ...
frveyklelkltprleigdC...agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

IIVMACNEFELGRhKCERYWVDEGeEHCFGDILVTQIGQQRVTkDFMIRTLKATRD------------KEEKIFNQFHYTAWPD-HGVPTSVKPILDMIK
 .|. ...|.  . ..  ||  .. .. .|.|.|  . ..  . .. |||.| |.              |..|  .|..| |.  . || | . ......
avvvLtktfdfak.mypsywpnks.keqygeifveiveekqya.nlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

LVREYQTAE-----EPPIVVHCSAGCGRTGTICVIDYvrnALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAV
 || ..        | |.||..| | .|.|  . ||    .|.| ...... ... .  .|..|  .|.. ..|  .   .
rvrlwrekvdedpeegPvvvvssdGasRsGvylaida...nlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvl
0046845 (Phosphotyrosine protein) phosphatases II 31-300 8.4e-87 286.4 In-house 3-278 (284) alignment 
Range on Protein: 31-300
Range on HMM: 3-278/284.0
ELEFNHLKQISQRYRtekvYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNV-EGSDYVNANFLKGA-----ANDHTYLAAQGPLPHTVNEFWRMLW
| || .| ..   .     ...|..    |. |||||||||.||||  |. .|.  |.|||.||....|       . ....|.|||||.||..||||.|
eeefeellsltvkll....lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvw

ECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQQRvTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREY
| |...||| ....| || ||..|| .|||   .||. || .  .   .|...|||. |.   ..|... ..||||.|||||||.|....|....||||.
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrel

QT--AEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHL
..    ..|||||||||.|||||....|.. . |. |... ........  .|.||.  |||  ||..|..|...... .|
lenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_PTPN13_pd Subfamily PTPN13 33-297 4.9e-66 217.8 In-house 16-270 (273) alignment 
Range on Protein: 33-297
Range on HMM: 16-270/273.0
EFNHLKQISQRYRtekvypTSAGESDVNMRKNRYKDILPFDHSRYLLSQidnvEGSdYVNANFLKGA--ANDHTYLAAQGPLPHTVNEFWRMLWECNTEI
||..|...    .      .. |... |..||||...||.|..|  |..    ||. |.||...|     . ..|.|.|||||.||..||.|.|| ..|.
efkelrelkpldt......cevgkkkenkdknryrnvlPydetrvklgd....egg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaev

IVMACNEFELGRHKCERYWVDEGEEHC-FGD-ILVTQIGQQRvTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTaEE
|.|  .| | |. ||.||| .. ...    . . |.....|.  ..| .|.|. .  . .| .   ......|||||||.| ...| ... ||. || ..
iamvtlekekgkvkchrywPesknkklkvsnrlevellkvqk.ldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.da

PPIVVHCSAGCGRTGTICVIDYVrnaLQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
 ||||||||| ||.||. .|| |   |.| . |..| . .|. ..|.||...|||..|| .|..|......
gPivvhcsaGiGrsGtlitidvv...lglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
0040438 (Phosphotyrosine protein) phosphatases II 34-301 3.9e-84 277.9 In-house 17-281 (317) alignment 
Range on Protein: 34-301
Range on HMM: 17-281/317.0
FNHLKQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVM
|. |..  ..... |....| .|  .|. ||||.||||.||||  || ......|||.||.. .|    ....|.|||||.||. ||||.|| ....|||
ftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

ACNEFELGRHKCERYWVDeGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVV
 ....|||| ||..|| . ||.  .||. || .. .   ... .|||. .  .|.|. . ..||||.||||||| | ...||....|||..  .. |..|
LteleelgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlV

HCSAGCGRTGTICVIDYVRNALQLEKidqNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLG
|||||.|||||....... . |. |.   ........  .|.||. .||| .||. ...|. .... .| 
HCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
DSPc_SM00195 35-296 3.2e-82 271.1 In-house 7-262 (263) alignment 
Range on Protein: 35-296
Range on HMM: 7-262/263.0
NHLKQISQRYrtekvyPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMA
..|..  .        .|. .| . |..|||||.|||.||.|  |..... |||||.|||..||| ....| |.|||||.||..|||| || ...|||| 
ekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CNEFELGRHKCERYWVDE-GEEHCFGDILVTQIGQQRVTKDFMIRTLKATRDK--EEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVV
..|.| |. ||.||| .| |..  ||.| |. . .. . ... .|||. | ..  |.. ..|..|..||||||| | |..|.... |.. .  ...||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
|||||.|||||...||.. . |. ||    ... .|.  .||||. .|||..||  ...|.....
hCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 35-296 3.2e-82 271.1 In-house 7-262 (263) alignment 
Range on Protein: 35-296
Range on HMM: 7-262/263.0
NHLKQISQRYrtekvyPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMA
..|..  .        .|. .| . |..|||||.|||.||.|  |..... |||||.|||..||| ....| |.|||||.||..|||| || ...|||| 
ekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CNEFELGRHKCERYWVDE-GEEHCFGDILVTQIGQQRVTKDFMIRTLKATRDK--EEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVV
..|.| |. ||.||| .| |..  ||.| |. . .. . ... .|||. | ..  |.. ..|..|..||||||| | |..|.... |.. .  ...||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
|||||.|||||...||.. . |. ||    ... .|.  .||||. .|||..||  ...|.....
hCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0036941 (Phosphotyrosine protein) phosphatases II 37-300 4.9e-83 274.1 In-house 22-281 (297) alignment 
Range on Protein: 37-300
Range on HMM: 22-281/297.0
LkqisqrYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLsqidNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACN
|      ..  . ...|....  |. |||||||||.||.|  |    . |||||.||....|   .....|.|||||.||..||||.|| |...||| ..
l......lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlte

EFELGRHKCERYWVDE-GEEHCFGDILVTQIGQQRV-TKDFMIRTLKATR--DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTA--EEPPIV
..|||| ||..|| .| ||. ..||. || .. . |  .|. .|||. |   ..|... ..|||| |||||||.|....||.|.|||... .  ...|..
lvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvl

VHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHL
||||||.||.||....|.. . |. ... .........  .|.||. .||| .||. ...|. . .. .|
VHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0043336 (Phosphotyrosine protein) phosphatases II 37-293 1.7e-81 269.0 In-house 22-274 (278) alignment 
Range on Protein: 37-293
Range on HMM: 22-274/278.0
LKQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACN
|..  ..... |....| ...  |. |||||||||.||||  || ......|||.||....|    ....|.|||||.||. ||||.|| ....||| ..
lllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte

EFELGRHKCERYWVdeGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCS
..|||| || .||   |.  ..||. || ....   .|...|||. |  .|.|... ...||..|||||||.|....||..| |||..  .. |..||||
lvelgrvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCs

AGCGRTGTICVIDYVRNALQLEKidqNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
||.|||||....... . |. |.   ...|.... ..|.||. .||| .||. ...|. 
aGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 37-297 1e-67 223.3 In-house 26-280 (315) alignment 
Range on Protein: 37-297
Range on HMM: 26-280/315.0
LKQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACN
.||  .     ...|        | .|||| .|...|.||  |  ..| ..||||||||..| .  . |.|||||.. .|..|||...| .   |||  |
fkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltn

EFELGRHKCERYWVDEgeEHCFGDILVTQIGQQrVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAG
  |  ..|.|.|| |.  .  .| | ||.. .. | ... .|||  . ... .   |.|||.||| ||| .  |....|. |. ..|..  .||||||||
lvegekrkaekywpdk..kviyGkitvtrksee.vnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaG

CGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
 ||||| . .| | . .. |..     .|..|  .|..|  .||. .||.... |... | 
vGrtGtfitldavldqaeaena...idvynfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_PTPN3_pd Subfamily PTPN3 37-297 1.3e-67 222.7 In-house 18-276 (280) alignment 
Range on Protein: 37-297
Range on HMM: 18-276/280.0
LKQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNvegsDYVNANFLKGAAND----HTYLAAQGPLPHTVNEFWRMLWECNTEIIV
|.|  | || ..   .||     |. ||||.||||.|. |  |.. ..    ||.|||...   .       |.|.||||..|...||.|.|| ....||
laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MACNEFELGRHKCERYWVDEGEEHCFGDILVTqIGQQRVTKDFMIRTL--KATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIV
|  .  | || || .|| ....|  .|.. |. . ... || ...| |  | .. |||.   |. |.||||||||.. . .|.... ||......| |.|
mlttlverGrvkChqyWPetedeleygefsvk.cekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvv

VHCSAGCGRTGTICVIDyvrNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
|||||| |||| . ...    ||.|  . ...   ||.  || || ..||| .||..|  |.. ...
vhCsaGigrtGvlille...talalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_PTPN1_pd Subfamily PTPN1 38-294 3e-58 191.9 In-house 9-269 (290) alignment 
Range on Protein: 38-294
Range on HMM: 9-269/290.0
KQISQRYRTEKV-YPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNvegsDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACN
|.| .  | |   .||.. . . |  .|||.|. |.||||  | . ||    ||.||....    .. |. .|||||.||. ||.|.|| ..  .||  .
keiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

EFELGRHKCERYWVDEGE--EHCFGD--ILVTQIgQQRVTKDFMIRTLKATR--DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQ--TAEEPP
  | .. || .||  . |  |  . |  . |. | .. ... ...|.|. .    .| .   .||||.||| ||| |    |...  |||    . .  |
vvekeqikcaqywPqgeeekellledtklkvkli.seerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGp

IVVHCSAGCGRTGTICVIDYVRnaLQLEKIDQ--NFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
 |.||||| ||.||.|..| .   ...|| |.  .  . . ....||.|. ..|| .| .. . |...
avihcsaGiGrsGtfclvdtcl..vliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN14_pd Subfamily PTPN14 38-297 2.3e-51 169.6 In-house 30-297 (300) alignment 
Range on Protein: 38-297
Range on HMM: 30-297/300.0
KQISQRYRtEKVypTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVeGSDYVNANFLKG--AANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMAC
 .|...   . .  .|... ..| .|||.||.||....|  ||   .   ..|.||  .|   ......|..|||||..||..||.|.|| ....|||  
eripkkre.dal..lstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

NEFELGRHKCERYWVDEGEEHC---FGDILVTQIG-QQRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILD---MIKLVREYQTAE---
.| | |..|. .|. ......    ||   ||.   ..  .   .  .||    |||.    . || |||||||  ||. |.   ... ||.  . |   
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

---EPPIVVHCSAGCGRTGTICVIDYVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
   .||..|||||| |||| . . | . ..|.    ...  .  ..  .|.||  .|||  ||. |..... ...
keskPPvlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 38-297 2e-41 136.7 In-house 18-294 (301) alignment 
Range on Protein: 38-297
Range on HMM: 18-294/301.0
KQISQRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDN--VEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMAC
..  .. ....  ... | |. | . ||.|.| ..|. | .|..  |  .   .|.||....|  . . . |||||. .|. .|||..|.  .  ||| .
eeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

NEFELGRHKCERYWVD-EGEEHCFGDILVTQIgQQRVTKDFMIRTLK-----------------ATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMI-K
|. |  ..|||.|| . | |.. || . || . .. |  ||.|| |.                  ..||. .   |.. | ||..||    . .|  | .
nlkegtkskceqywpnseaeseefgpftvtlv.neqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvidd

LVREYQTAEEPPIVVHCSAGCGRTGTICVIDYvrnALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
 .   |  .  |.|||||.. .|.|. | ..    .|   | .    .....  .|...   |.| .||  .. ..  ..|
vihrqqkigggpvvVHCSdtVsrsGvYcsvsi...glEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_egg_pd Subfamily egg 39-303 2.3e-23 77.4 In-house 21-277 (307) alignment 
Range on Protein: 39-303
Range on HMM: 21-277/307.0
QISQRYRTEKVYPTSAgeSDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEF
....    |. . |.|  || |. | | | .   | ||  |         |.. || .||     ... || ||  ||..||||... . . |||     
evleesvdeislttaa..sdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrk

ELgrHKCERYWVD-EGEEHCF--GDILVTQIGQQ-RVTKDFMIRTLKATRDKEEKIFNQFHYTawpDHGVPTSVKPILDMIKLVREYQTaeepPIVVHCS
|   ..|| ||   | .   .  | . .. .. . .    | .  ||    ..|. | .       |    . |   | .....|.  .    |.||.. 
es..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg...dvnnssdvysplrvlrklrnlsk....pvvvqdi

AGCGRTGTICVIDYVRNALQLEKIdQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLGIK
 |. ...|.  |.     |    |   . .   .| .|..|.  |..  .| .|.| |. .|.  .|  
lGvskaatlvaieiallsllrGpi.tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa
subfamily_PTPRN_pd Subfamily PTPRN 42-298 1.1e-56 186.8 In-house 39-294 (297) alignment 
Range on Protein: 42-298
Range on HMM: 39-294/297.0
QRYRTEKVYpTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGA-ANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFEL
 .|..|.   ....... |..|||.|..||.||||  |..  . | |||.|| ..        .|.|.||||..|| .||.|.||  . .||. ..  | 
cayeaepst.kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleee

GRHKCERYWVDEGEEhCFGDILVTQIGQQRVTKDFMIRT--LKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCG
| ..|.||| |||.|  ..   |  . .   ..|...|.  ||  . .| .   |||. .||..|||.| |..|.. . |         |||||||.|.|
gvkqckrywpdeGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGTICVIDYVRNalQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
|||. ..|| | |  .| |  ..  .   .  .| ||. .|.|..|.|..  ||..  .|
rtGvyilidlvln..rllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevna
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 42-155 3.5e-09 30.6 In-house 16-128 (332) alignment 
Range on Protein: 42-155
Range on HMM: 16-128/332.0
QRYRTEKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEgsDYVNANFLKGAANDHTYLAAQGPLP-HTVNEFWRMLWECNTEIIVMACNEFEL
| . .   || .  .   ||  ||   .  |||||  |.  |  .  |. ||... | ..  .|. || |.  ||   ||||. | .  .|..  .  | 
qmhtsamtypntydkflnnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek

GRHKCERYWVDEGEE
 ..|.     | | |
qkrkapydisdrgfe
subfamily_ptpA1_pd Subfamily ptpA1 46-246 4.9e-43 142.4 In-house 31-249 (418) alignment 
Range on Protein: 46-246
Range on HMM: 31-249/418.0
TEKVYP--TSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANdHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRH
 | | |  || |.   |  |||| .||| .|.|  | .|.. |||||.|||.. ||   . ....||||| |. .||||.||    ||||   | |  | 
eesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmlsresencri

KCERYWVDE--GEE--------HCFGDILVTQIG-QQRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTA------EE
||.||| ..  ||.          ||   |  .   |   .. . | .. | . | .   |..|  |||| .|   .|. .... . . |         .
kcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrn

PPIVVHCSAGCGRTGTICVI
 ||.|||||| |||||.|  
vpiivhcsagvgrtgtfcta
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 47-295 1.1e-61 203.5 In-house 30-275 (515) alignment 
Range on Protein: 47-295
Range on HMM: 30-275/515.0
EKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCE
 ..|| .  . ..| .|||||.|||.| .|  |  |..   |||.|| ....  ||..|.|.|||.. .|..|||.... |.  |.|  .  |  . || 
pniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcg

RYWVD-EGEEHCFGDILVTQIGQQRVTkDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICV
.|| |  |.   || | |  .  .  | . ..|.|. ..... .   |||.| |||.|||   . .| .|| |.  .   . |...||||| |||| .. 
kyWPdkpgdsvkfGsikvelvsleact.ggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvis

IDYVRNALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
|| |       |  .   .....  .|..|  .|||..|| ... || . 
idsvvaha...kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 47-297 2.1e-60 199.4 In-house 38-285 (297) alignment 
Range on Protein: 47-297
Range on HMM: 38-285/297.0
EKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGaaNDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRhKCE
 ...|.   |  ||. |.|||.|||.| ||  |  ...   |||||| |.||  | | ... | | . ||..||.|... .. .|||  .. |  . || 
aniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg..nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kca

RYWVDEGEEHcFGDILVTQIGQQRvTKDFMIRTLKATRDK--EEKIFNQFHYTAWPDHGVPT--SVKPILDMIKLVRE-YQTAEEPPIVVHCSAGCGRTG
||| |.|    |||. |.    ..  . |. |.|. |..|   ... .|.... |||. |.   |.. .|..|. ||. ... .| |..|||.|| ||||
ryWsdkgvtt.fGdvsvvllsvse.reGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

TICVIDYVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
 .. || |    .    ...  .....  .|..|  .|||..||..|. ||.... 
vlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 47-294 1.5e-47 156.8 In-house 32-234 (392) alignment 
Range on Protein: 47-294
Range on HMM: 32-234/392.0
EKVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNeFELGRhkce
 ..||..... ..|..|||||.|||.| .|  |  ||..  |||.|| ....  |...|.|.||| . ....||||... |.  |.|  . .. |     
pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtk.lkegd....

rywvdegeehcfgdilvtqigqqrvtkdfmirtlkatRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVI
                                     . .. .   |||.| |||..||  .  .| .|| |.        |...||||| |||| .  |
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

DYVRNALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
| |       |  .   ........|..|  .|||..|| ... ||..
dsvvaha...kktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 48-298 6.1e-67 220.9 In-house 34-285 (305) alignment 
Range on Protein: 48-298
Range on HMM: 34-285/305.0
KVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCER
.  ..  |....| .|||.|.| ..|..|. |.. .... |||.||....|  . ..|..|||||..||..|||...|. .. ||| ..  | |..||..
eeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrq

YWVDEGEE-HCFGDILVTqIGQQRVTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEP-PIVVHCSAGCGRTGT
|| ..  | . ||.. |. . ... ..|...| ||..    |||..   |.. | |||||||..   .|..|| |.. |  ..  |..|||||| ||||.
YWpesktekkefgefsve.lksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGv

ICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
 ...|   . |. |   .   .....  .|..|  .||| .||  .| |. .. ..
fiavdialerlkkE...evvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 48-295 1e-60 200.2 In-house 32-276 (315) alignment 
Range on Protein: 48-295
Range on HMM: 32-276/315.0
KVYPTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCER
..|.. ..  ..|..|||||.|||.|..|  |  ||.   |||.|| ..|.  .|..|.|.||||. .|..||||... ..  |||  .  |  . || .
diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWVD-EGEEHCFGDILVTQIGQQRVTkDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVI
|| | ...   || | |. .  .  | | ..| |   . .| .   ||..| |||.||.  .  .| .|| |.  .  .| ...|||||| |||| .. |
ywPdrkadsvefGsikvellsleadt.dgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisi

DYVRNALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
| | . .   |  .   .....  .|..|  .|||...| ... || . 
devvaqi...krtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_eak_pd Subfamily eak 48-206 3.3e-09 30.6 In-house 40-196 (332) alignment 
Range on Protein: 48-206
Range on HMM: 40-196/332.0
KVYPTSAGESDVNMRKNrYKDILPFDHSRYLL-SQIDNVEGsdYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCE
..   | ..   ....|   .|.|.|.    | |   | .|  |.||  .. .   . |. .  .    |  ||.|. | ..  ||.  .. ||.  | .
rllsisetarleavnrn.vvkivpydrylvrltssqlnrlG..yinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksd

RYWVDEG-EEHCFGDILVTQIGQqRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPT
.|. |.. ||  || . |..       . .  | |. ..  | .    ...  | .  .| 
kyfpdktreelkfGildverkef.vkrniletrllelskGnethrvlhykvfGwtettlpk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 50-110 1.6e-10 35.1 In-house 38-95 (95) alignment 
Range on Protein: 50-110
Range on HMM: 38-95/95.0
YPTSAGESDVNMRKNRYKDILPFDHSRYLLSQidnVEGSDYVNANFLKGAANDHTYLAAQG
 | ..| |. |. |||. .|.|.| .|  |.       |||.|| |. | |    |.||||
apytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
0040439 (Phosphotyrosine protein) phosphatases II 51-294 6.8e-76 250.4 In-house 2-244 (249) alignment 
Range on Protein: 51-294
Range on HMM: 2-244/249.0
PTSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV
..| ..  .|. ||||.||||.||||  || ......|||.||....|    ....|.|||||.||. ||||||| . ..|||.....|||| ||..|| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DeGEEHCFGDILVTQIGQQRvTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTA--EEPPIVVHCSAGCGRTGTICVI
. |..  .||. || .  .   .|...|||. |   |.|.   ....|| ||||||| |....||.|..||.....  .. |..||||||.|||||....
l.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
... . |. |   ....|.... ..|.||. .||. .||. ...|. .
ylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 52-134 8e-06 18.9 In-house 19-74 (169) alignment 
Range on Protein: 52-134
Range on HMM: 19-74/169.0
TSAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNAnflkgaandhtylaaqgplphtvnefwRMLWECNTEIIVMA
    |  .|  |||    |   | |  | .. .  ||||.||                           ||.|| |. .||. 
nfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 53-296 1.2e-63 209.7 In-house 13-264 (270) alignment 
Range on Protein: 53-296
Range on HMM: 13-264/270.0
SAGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAAN-DHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD
.  |   . . |||.||||  ..|  |..... . . |.|||...|. . ...|.||.|||| |...||||.|| ... |||. .  | ||.||||||  
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

EGEE---HCFGDILVTQIGQQRvTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVK------PILDMIKLVREYQTAE--EPPIVVHCSAGCGRT
| .|     .|.| |... ... .. .... |. ... ||.    |.|..|||||||..         .| |.. ||....    . |..|||||| |||
epkekvkledgkikvlalseek.eegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GTICVIDYVRNALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
||. ..|.. ..|. .   ..  .  || ..||.| |.||. .|||....|||   
GtlialDiavrlLeet...kkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 54-297 3.2e-65 214.8 In-house 3-243 (250) alignment 
Range on Protein: 54-297
Range on HMM: 3-243/250.0
AGESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHkCERYWVDEG
 ..   |  |||| ||...|.|| .| . .  . |||.|| ||.|  . ....|.||||..|...||||..| ... |||  |  | ..  ...||  |.
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

EEHcFGDILVTQIgQQRVTKDFMIRTLKATRDKEE--KIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTA-EEPPIVVHCSAGCGRTGTICVIDYVR
 |. .||..|.   .. .  |...|.|| .. |..  .|  |.|...||| |||   . .|...| |.  |   .. |..|.|||| ||.|. ..|| | 
aek.yGdvtvsll.skeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

NALqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
. |   |...   ....|  .||.|   |....||  |....  . .
erl...kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
0042113 (Phosphotyrosine protein) phosphatases II 55-294 3.3e-74 244.6 In-house 4-241 (245) alignment 
Range on Protein: 55-294
Range on HMM: 4-241/245.0
GESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDeGE
..  .|. ||||.||||.||.|  || ... ..|||.||.. .|    ....|.|||||.||. ||||||| . ..||| ..|.||||.||..|| . ||
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

EHCFGDILVTQIGQQRvTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQT-AEEPPIVVHCSAGCGRTGTICVIDYVRN
.  .||. || .. .   .|...|||. |  .|.|..  ...||. |||||||.... .||....||...   .. |..||||||.|||||....... .
sltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

ALQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
 |. |   ...||.... ..|.||. .||| .||. ...|. .
qleke...lgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPRK_pd Subfamily PTPRK 55-294 1e-62 206.8 In-house 38-275 (314) alignment 
Range on Protein: 55-294
Range on HMM: 38-275/314.0
GESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGE
   | | .|||..|||..|.||  | .||.   |||.||... .  . . ....||||..||..|||.... |.  |||  .  | || || .|| ...|
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedte

EhcFGDILVTQIGQqRVTKDFMIRTLKATR----DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVR
   .||| |. .    . .....|... ..     .| .. .||....||||.||.| . .|.... | . |  |. .||||||||.||||| ..|| | 
v..ygdikvelvet.ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl

NALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
. .. |..     .. .. ..|...  .|.| .|| ... ....
dmieregv...vdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 55-294 4.2e-38 125.9 In-house 28-293 (297) alignment 
Range on Protein: 55-294
Range on HMM: 28-293/297.0
GESDVNMRKNRYKDILPFDHSRYLLSQidNVEGSDYVNANFLKGAA--NDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD-
   .  .|||||.||| .| .|  | .   . ..||.||...      .|  |. |||||  ||..||....| .  .||| ..  | ||.||  || . 
akrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

EGEEHCFGDILVTQIGQQRVTKD-FMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSV-----------------KPILDMIK-------LVREYQTAEE
..|    ||..|  . .     |  ..  |.    .|..  .   . .|||||||. .                   .| ...       |  |   || 
vqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraem

P---PIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQNFSlydIIVDMRKQRHAIVQTRNQYELVHRAVVD
|   ...|||||| ||.| .   | . . |. ..| .  .   |.  .|.||  .||| .|.||.. ||. 
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaa...ilsilreqrarlvqtleqfellydavlk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 55-99 1.1e-07 25.6 In-house 42-86 (440) alignment 
Range on Protein: 55-99
Range on HMM: 42-86/440.0
GESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGA
     |  ||||..|| .|||| .| ..  |  |||.|| ...| 
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_PTPN9_pd Subfamily PTPN9 56-296 3e-67 221.7 In-house 38-290 (297) alignment 
Range on Protein: 56-296
Range on HMM: 38-290/297.0
ESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV-DEGE
.. .|..||||.|.| .|..|  |...|. | |||.||||. |  . ....|.||||..||..||||.|| .. .|||.    | || || .||  .|..
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

EHCFGDILVTQIGQQrVTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQT-------------AEEPPIVVHCSAGCGR
 . |||. |... .. ...|...|.|...  ...|..    | ...|||.||| | . .||... |||.|.             ...|||||||||| ||
saefgdlsvsnveve.eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGr

TGTICVIDYVRNALQleKIdQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
||| . .|.  . |.  .. ..  . . .  .|.||   .|| .|||. . ||..  
tGtfitldiclsrle..ev.gtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 56-293 4.7e-46 151.9 In-house 4-238 (239) alignment 
Range on Protein: 56-293
Range on HMM: 4-238/239.0
ESDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGA-ANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGE
.  ||  |||| .|. .|||| .| .. |   |||.||..|.    . ..|.|.|| .  .  .||||.|.    .|||     |  ..|| .|| |   
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

EHCfgDILVTqIGQQRVTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVrna
..|  .. || . .  |  |..|||.  .   . ||.   |.|.| |||.|||     .| . . . .       | |.||||| ||||.. ||| .   
kyc..nlrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam...

LQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
|.  | ..   ... .  .|..|  .||| .|| ..| ||.
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 56-299 2.1e-38 126.6 In-house 33-272 (281) alignment 
Range on Protein: 56-299
Range on HMM: 33-272/281.0
ESDVNMRKNRYKDILPFDHSRYLLSQ-IDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGE
.  || .|||| .|  .| ||  |   . | . .||. ||...     . |. .|||   |  .||||.|. ||  ||| |.  |  | ||  |.  .  
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

EHCFGDILVTQIGQQRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPildMIKLVREYQTAEEPPiVVHCSAGCGRTGTICVIDyvrnaLQ
     | |  .  .  | | ..   |. . . | ..  .. .  |||  || | .    |.|..|. ..   || |.||||| ||.||.  ..     . 
cclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessev...mlkilrkirarstpp.vihcsagvgrsgtlmave.....ia

LEKIDQNFSLYDI---IVDMRK-QRHAIVQTRNQYELVHRAVVDMFQAH
|. |   |.| ||   .  .|   | | ||| .|| |. . ..|.  |.
lqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvay
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 56-127 1e-07 25.8 In-house 33-109 (347) alignment 
Range on Protein: 56-127
Range on HMM: 33-109/347.0
ESDVNMRKNRYKDILPFDHSRYLLSQIDNVE-----GSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECN
| . .. ||| ||    | .| .||  .           |.||  .|    .. |. .| |||.|| .||.|.   .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtk
0045098 (Phosphotyrosine protein) phosphatases II 57-297 1.3e-73 243.1 In-house 30-273 (278) alignment 
Range on Protein: 57-297
Range on HMM: 30-273/278.0
SDVNMRKNRYKDILPFDHSRYLlsqidnvegsDYVNANFLKGAanDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDeGEEH
   |. |||||||||.||||            ||.||....|   .....|.|||||.||. ||||||| ....|||.....|||| ||..|| . |.  
ylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsl

CFGDILVTQIGQQRVtKDFMIRTLKAT------RDKEEKIFNQFHYTAWPDHGVPTSV--KPILDMIKLVREYQTA-------------EEPPIVVHCSA
 .||. || .  ... .|. .|||. |       | |.  ....||. |||||||..   |..|.... .||.. .             .. |..|||||
tygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GCGRTGTICVIDYVRNALqlekiDQNFSLYDIIVDMRKQRHA-IVQTRNQYELVHRAVVDMFQ
|.|||||........  |     .....|....  .|.||.  .||. .||. ..........
GvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0037934 (Phosphotyrosine protein) phosphatases II 57-294 3.8e-71 234.8 In-house 7-240 (243) alignment 
Range on Protein: 57-294
Range on HMM: 7-240/243.0
SDVNMRKNRYKDILPFDHSRYLLsqidnvEGSDYVNANFLKGAanDhTYLAAQGPLPHTVNE----FWRMLWECNTEIIVMACNEFELGRHKCERYWVde
. .|. ||||.||||.||||  |      |||||.|||. ..   . .. | |||||.||..    ||||||| ....||| ....|||| ||..||   
lpenlsknrysdilpydhsrvkl......egsdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

GEEhCFGDILVTQIGQQRvTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREY--------QTAEEPPIVVHCSAGCGRTG
||. ..||. || ....  ..|...|||. ..   |....   ..||..|||||||.|....||... |||.        .  .. |..||||||.||||
gev.tygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TICVIDYVRNALqlekidqNFSLYDIIVDMRKQRHA-IVQTRNQYELVHRAVVD
|.......   |       ...|.... ..|.||.  .|||..||. ...|.  
tliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 57-296 3e-55 182.6 In-house 45-288 (325) alignment 
Range on Protein: 57-296
Range on HMM: 45-288/325.0
SDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRML--WECNteiIVMACNEFELGRHKCERYWVDE-G
   |. |||.|.....|.||  |   ..   |||.||..|.   . ...|||| ||..|.|..||..  |.|    .|.  ||..|| ..|  || .| |
kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs...vvvvlneldlgkdrcavywpkemg

EEHCFGDILVTQIGQQRVtKDFMIRTLK--ATRDKEEKIFNQFHYTAWPDHGV---PTSVKPILDMIKLVREYQTA---EEPPIVVHCSAGCGRTGTICV
.   || . |  .  . .  |.. | |.   ... | .  .||.. .|.| ||   |... .||...| | |  ||      ||.|||||| ||||.   
ksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

IdYVRNALQLEkiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
. |   |  .|  . .  ... .  .||.| ..|.| .|| |.. |.|...
l.ysalakvie..esrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 57-294 4.4e-46 152.0 In-house 4-238 (239) alignment 
Range on Protein: 57-294
Range on HMM: 4-238/239.0
SDVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGA-ANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEE
  ||  |||| .|. .|||| .| .. |   |||.||..|.    . ..|.|.|| .  .  .||||.|.    .|||     |  ..|| .|| |   .
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

HCfgDILVTqIGQQRVTKDFMIRTLKAT--RDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVrnaL
.|  .. || . .  |  |..|||.  .   . ||.   |.|.| |||.|||     .| . . . .       | |.||||| ||||.. ||| .   |
yc..nlrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam...l

QLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
.  | ..   ... .  .|..|  .||| .|| ..| ||..
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 57-296 2e-43 143.1 In-house 53-283 (290) alignment 
Range on Protein: 57-296
Range on HMM: 53-283/290.0
SDVNMRKNRYKDILPFDHSRYLLSqiDNVEGsDYVNANFLKGAanDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD-EGEE
 . ...||||||.   | .| .|.  |  .| ||| ||..||   . ... .||.|  || ..|||. . ..  ||| |. .| |. |||.|. . ||| 
kntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

HCFGDILVTQIGQQRVTKDFMIRTLKATRDKE--EKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTaeepPIVVHCSAGCGRTGTICVIDYvrnAL
  ||.| |.   ..   .. . .||     ..  |.... ..  .|||. |. |   .| ... .|.       |.||||||| |||||.  |.    .|
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaiev...gl

QLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
|.    ... | |..  .|. | . ||   || .. ....|. 
qilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 57-296 5.2e-33 109.2 In-house 32-270 (285) alignment 
Range on Protein: 57-296
Range on HMM: 32-270/285.0
SDVNMRKNRYKDILPFDHSRYLLSQIDNvegsDYVNANFLKGAAND-HTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDE-GE
 . |   ||| |.   . .| .| . |     ||. |....   .|  ||...||||| |...||.|... .   ..| |  || |  ||  |. .. ||
yeanpdlnryadvrcieetrvvlknhdr....dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

EHCFGD--ILVTQIGQQRVTKDFM-IRTLKATRDK--EEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAeEPPIVVHCSAGCGRTGTICVIDYV
   ||   | .|.  .. ..   .   |.  | |   |   .|. .   |||.  |   .|.... | |.. .   | ||.|||||| ||| |.  ||| 
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidya

RNALqLEkiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
   . .|  . |  . ||. .||  |   ||.. |. ...  ... |
tiri.me..npniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 58-317 1e-60 200.6 In-house 23-277 (284) alignment 
Range on Protein: 58-317
Range on HMM: 23-277/284.0
DVNMRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACnefelgRHKCERYWVDEGEEH-
| |  |||. .||.||...  | ... .|.|||.|| |..|  . . |.|.||||. |...||||.|| |.  ||.        ..|| .||  ..... 
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivike

CFGDILVTQIGQqrvTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAE--EPPIVVHCSAGCGRTGTICVIDYVRN
  ... |. . .   ......| .. ..    |. .  .|||.  |||.||| .  ... ..| ||  .. |  . .||||||||.||||.  |.| . .
erfkvkvdsvee...seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

ALQLEKidqNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD-MFQAHLGIKPEDYGHNYENVQLK
 .. ||      .|... |.|.||  .||   || ... |...  . .|  .   |.   .|.   |
rmkeek...qvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 58-298 4.7e-45 148.9 In-house 39-279 (307) alignment 
Range on Protein: 58-298
Range on HMM: 39-279/307.0
DVNMRKNRYKDILPFDHSRYLLSqIDNVeGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYW-VDEGEEH
. |  ||||.|.   |..| ..  .| .  |||. ||.|  | . . ...|||||  |. .|| |  . . | ..| |.  ||.. |||.|| ..||.. 
santdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

CFGD----ILVTQIGQQRVTKD---FMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVReyqtAEEPPIVVHCSAGCGRTGTICVIDYV
 ||.    | |...| .... |     . |||    .. .  ... .. |||.|||      ..... ||     .. |.||||||| ||.|||  | .|
vfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvvvhcsaGvGrsGtivaislv

RNALqLEKIdQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
.. . .. |    .. ... ..|.|||  .||  ||  .|| ... |  
qdkm.iaGi.nckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
0049772 (Phosphotyrosine protein) phosphatases II 58-297 6.7e-44 146.2 In-house 44-281 (314) alignment 
Range on Protein: 58-297
Range on HMM: 44-281/314.0
DVNMRKNRYKDILPFDhSRYLLsQIDNVEGSDYVNANFLKGAandHTYLAAQGPLPHTVNEF----------WRML--WECNTEIIVM------------
 .|. ||||.||||.| .|. | .  .|.|||| ||....|     ...|.||||..||. |          |||   .. |. .|||            
flnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------ACNEFELGRHKCERYWVDEGeehcfgdilvtqigqqrvtkdfmirtlkaT----RDKEEKIFNQFHYTAWPDHGVPtSVKPILDMIKLVRE
          ..  ..| . ..... .                               .    ... |.   ..... .||...| . . .........|
LdaAlgKtpllildgngneptaadlellk.............................eelydpelferlgikylripvpDgsap.lledfdeflefiee

YqtAEEPPIVVHCSAGCGRTGTICVIDYVRNALqlekidqNFSLYDIIVDMRKQRH-----AIVQTRNQYELVHRAVVDMFQ
.   .. |..|||.||.||||| .|..|.  .|       ..|| ... |.|..|.       ... .||| ...|. . ..
a..dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 58-101 1.3e-08 28.7 In-house 37-79 (244) alignment 
Range on Protein: 58-101
Range on HMM: 37-79/244.0
DVNMRKNRYKDILPFDHSRYLLSQIdNVEGSDYVNANFLKGAAN
 .|  |||| .|||||..| .||   . |||||.|||...|. |
sanatknryinilpfdetrvilsss.kkegsdyinanyiqgsqn
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 59-292 5.3e-22 72.8 In-house 46-275 (303) alignment 
Range on Protein: 59-292
Range on HMM: 46-275/303.0
VNMRKNRYKDILPFDHSRYLLSQidnvegSDYVNANFLKGAANDHTYLaAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCF
 || |||. |.. .|||.  ||.      | |. |..|.  .. .. | .| ||.||  .||.|. | .   ...   . |  .   .  .  . .   |
knmdknrfvdvicldhskvklsd......ssyihasyleldsskkail.tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GD--ILVTQIGQQRVTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTS-----VKPILDMIKLVREYQTAeEPPIVVhCSAGCGRTGTICVIDYVRN
 .  | | .. .  ... . .. |  .  .   ..   || |||   .|.      || | ..  ..| |  . .|.. .   .||||.||.....    
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysds.tptvym.slsgcgragtfalfetahl

ALQLEKidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAV
.|. |.    . |   .  .|. |   ||   |. .|.  .
slhseq..asldlvkclenvrngrlhavqnlsqfsvvytll
Y_phosphatase Protein-tyrosine phosphatase 60-293 1e-75 249.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 60-293
Range on HMM: 1-234/235.0
NMRKNRYKDILPFDHSRYLLsqiDNVEG-SDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV-DEGEEHC
|..|||||||||.|..|  |   .. || |||.|||..||  ......|.||||..|...||||.|. ....||| ... | || ||..||  .|.|.  
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDILVTQI-GQQRVTKDFMIRTLKATRDKEEK---IFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNAL
.||| |.    ... .|....|.|. . .|||.   ...|.|||.|||||||.|.|..||.|. |.....|.. |.|||||||.|||||....|.. . |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

QLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
. |.    .....|.  .||||. .||. .||. ...|..
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 60-293 1e-75 249.5 In-house 1-234 (235) alignment 
Range on Protein: 60-293
Range on HMM: 1-234/235.0
NMRKNRYKDILPFDHSRYLLsqiDNVEG-SDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV-DEGEEHC
|..|||||||||.|..|  |   .. || |||.|||..||  ......|.||||..|...||||.|. ....||| ... | || ||..||  .|.|.  
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGDILVTQI-GQQRVTKDFMIRTLKATRDKEEK---IFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNAL
.||| |.    ... .|....|.|. . .|||.   ...|.|||.|||||||.|.|..||.|. |.....|.. |.|||||||.|||||....|.. . |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

QLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
. |.    .....|.  .||||. .||. .||. ...|..
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 60-296 3.4e-51 168.7 In-house 1-171 (182) alignment 
Range on Protein: 60-296
Range on HMM: 1-171/182.0
NMRKNRYKDILPFDHSRyllsqidnveGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACnefelgrhkCERYWVdegeehcfg
|. ||||.||||.||||          ..||.|||.. |.  . ...|.||||..||..|.|||.| .  .||...         .|.||          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

dilvtqigqqrvtkdfmirtlkatrDKEEKIFNQFHYTAWPDHGVPTsVKPILDMIKLVREyqtaEEPPIVVHCSAGCGRTGTICVIDYVRNAlqlekid
                         ...|.   |..|. |||||||. .  .||.|. |.|    |. |..||||||.|||||........         
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.......

qNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
 ..||....  .|..|. .|.| ||| ....|. ...
.gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 60-293 7.1e-45 148.1 In-house 3-236 (237) alignment 
Range on Protein: 60-293
Range on HMM: 3-236/237.0
NMRKNRYKDILPFDHSRYLLSQIDnvEGSDYVNANFLKGAA-NDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCF
|  |||| .|  .|||| .|       ||||.||..|||     ..|.||||||  . ..||.|.|. .  .|||     |  . || .|| .  .  ..
nkiknrygnivaydhsrvvlkgag..sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDILVTqIGQQRVTKDFMIRTLKATR---DKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVRE--YQTAEEPPIVVHCSAGCGRTGTICVIDYVrnaL
| . |. . ..    |. .|.|  ..    || ..  |...|.|||.|||     .| . | . .     .|  | ..||||| |||| . ||| .   |
gvltvs.lkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam...l

QLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
.  |  .   .|. .  . ..|  |.||..|| ..|....
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 60-298 2.1e-37 123.5 In-house 48-289 (305) alignment 
Range on Protein: 60-298
Range on HMM: 48-289/305.0
NMRKNRYKDILPFDHSRYLLsqiDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD-EGEEHCF
.  ||||||.  .|. |  |   ..    .|. ||..   .| . .. .| || .|  .|| | .. . | | | ||  | | .||  |.   ....  |
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

GD--ILVTQIGQQRVTKDFM-------IRT---LKATrDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYqtaeEPPIVVHCSAGCGRTGTICVI
 .    ..   .  || .|         .|   .. .  .. .  ...|.  ||| |||..   ||....  |        ||||||||| ||||.. ..
eekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgsvvml

DYVRNALQLEK-IDQNfslYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQA
.|. . |   . |..      |.. .|.||   .|| .|| .||. ....|. 
eyildqllagqiiedt...dkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 60-295 1e-36 121.5 In-house 43-270 (288) alignment 
Range on Protein: 60-295
Range on HMM: 43-270/288.0
NMRKNRYKDILPFDHSRYLLSqidnVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYW-VDEGEEHCF
|  ..||...   | .|  ||     .   |..|| .  | ...  . || ||  |..|.|.|| | . | ||| |.  |.|..| . |. .  ||.  .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GDI-LVTQIGQQRVTKDFMIRTLKATRDKEEKI-FNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTaeepPIVVHCSAGCGRTGTICVIDYvrnALQLE
| .  |..  .. . |   . .|. ..  |||.   . |.  |.|.||| . .. | ... ....|     |||||.||| |||||. .|     ||.  
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk....PivvhssaGvGrtgtlilili...alesl

KIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
..| . ..  ..  .|..|   .|| .||  ||| | . 
rlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 60-293 1.4e-34 114.1 In-house 52-287 (310) alignment 
Range on Protein: 60-293
Range on HMM: 52-287/310.0
NMRKNRYKDILPFDHSRYLLsQIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFG
.| |||| |..  | ||  | .||.    ||. ||..|      |.. .|||| ||. .||||...  .| |.. |.  | || ||  ||   |    .|
ymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

DILVTQIGQQrvTKDFMIRTLKATR------------DKEEKIFNQFHYTAWPDHGVPTSVKPILDMiKLVreyQTAEEPPIVVHCSAGCGRTGTICVID
 | ||....   ...| |  |  |             . .|   .  ..  ||| |||      .   .|.         | ||||||| .|..... ..
cirvtnlses..seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq.rll...aqvrhgpcvvhcsagkdrlyvvvalk

YVRNALQLekiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVV
.  . |.     ..  . ... ...|.|   .||  || ...|  .
lkidkldr...glkvdaeevktellksraiciqtelqyliidrvri
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 60-300 9.6e-13 42.2 In-house 51-289 (302) alignment 
Range on Protein: 60-300
Range on HMM: 51-289/302.0
NMRKNRYKDILPFDHSRYLLsqidNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTV---NEFWRMLWECNTEIIVMACNEFELGRhKCERYWVDEGEE-
|..||. .|.   |. .  |    . |  .||||  ..     .. . || |   ..   .||||| .. .   .|..  | || .   . ..  . .. 
nlkknqsedvpildsnlvkl....eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

HCFGDILVTQ--IGQQRVTK-DFMIRTLKATRdKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNA
. .|.. | .  . ..  .|  ..|  |      .  . |  . | |... ||...  .   .. | . ..  . ..|.    |.|| |.. .   . . 
keygkmfvNnrkVekaeeektryviEvlPegc.snsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavek

LQLEkidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHL
|| .   ..    .|.  .|.|| ..|.. .||  ...|..  .. ..
lqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkkv
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 61-294 1.4e-61 203.0 In-house 29-266 (274) alignment 
Range on Protein: 61-294
Range on HMM: 29-266/274.0
MRKNRYKDILPFDHSRYLL-SQIDNVEGSDYVNANFLKGAAN-DHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEE---
 .|||||.||| ..|| || |.  . | |.|.|||..||  . ...|.|.|||||.||..||||... ....|||  .  |  ..||..|. |. .    
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

HCFGDILVTQIGQQRvTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEE---PPIVVHCSAGCGRTGTICVIDyvrNA
. .||. ..  .  . ..|. .|.|     ..|.    . ||.|||| .| .....||... |.| ...|.    |.||||||| ||||    |.   .|
erygdveikvekive.rndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais...ia

LQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVD
..  . ..   .  |....| .|  .|||..||||.|||.. 
vrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_CG42327_pd Subfamily CG42327 61-219 7.7e-27 88.8 In-house 29-191 (319) alignment 
Range on Protein: 61-219
Range on HMM: 29-191/319.0
MRKNRYKDILPFDHSRYLLSQIDNVEGSDYVNANFLKGAANDH-TYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDE--G-EEH
  |.|. ...|. ..|  | .| . . . |..|....|  . .  |.||| .|  .  .|||..|| .. .|| ... .||| ..| .|.  .  . ...
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

CFGDILVTQIGqQRVTKDFMIRTLKATRDKEEKIFNQFH--YtAWPDHGVPTSVKPILDMIKLVR
 .||||||  | . | . ..| ||   | ..|.  .  |  |  |.. .||.. .... |.  ||
lyGdilvtlkg.revkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 62-152 2.3e-23 77.5 In-house 49-153 (350) alignment 
Range on Protein: 62-152
Range on HMM: 49-153/350.0
RKNRYKDILPFDHSRYLLS--------QIDNVEGSDYVNANFLKGA------ANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCER
 |||||.|||..|||  |         .   ....||.|||.|| .        |. |.|.|.||| ||..|.... . . ..|..  ...||...||.|
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWVDE
|| . 
YWqeg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 62-151 2.4e-15 50.7 In-house 50-155 (349) alignment 
Range on Protein: 62-151
Range on HMM: 50-155/349.0
RKNRYKDILPFDHSRYLLSQ--------------IDNVEGSDYVNANFLKGA--ANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKC
 |||||||||..|||  | .               |     ||.|||.|| .  . .. |.| | ||| ||..|....   . ....   ...||. .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

ERYWVD
..|| .
diywqe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 63-299 7.5e-31 102.0 In-house 46-279 (312) alignment 
Range on Protein: 63-299
Range on HMM: 46-279/312.0
KNRYKDILPFDHSRYLLSQIDNVegsdYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVD-----EGEEHC
 ||| .|  .|  |. |.  .|     |. |||.|  ..   ....||||  |.  ||..     .  |.. |   | | .|| .|  |     . |.| 
lnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

FGDILVTQI-----GQQRVTKDFMIRTLKATRdKEEKiFNQFHYTAWPDHGVPTSVKPILDMIKLVREyqtaEEPPIVVHCSAGCGRTGTICVIDYVRNA
     .|.|      ....|.  .   .|||  .| | .|.. ...|||||.| |.   | ..  |.     .  |.. ||||| |||||...|. .  |
vyteycteieiggkskdkithrvlkvvvkatg.qesk.lnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmiaa

LQLEKiDQNfsLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAH
|.  .  ||  . |. | .||.|   |..  ||  . |.|.... ..
lrhpr.kqn..vkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
0044763 (Phosphotyrosine protein) phosphatases II 71-290 9.3e-38 125.0 In-house 1-165 (178) alignment 
Range on Protein: 71-290
Range on HMM: 1-165/178.0
PFDHSRYLLSQIDNVEGSDYVNANFLKgaanDHTYLAAQGPlphtvNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEehcfgdilvtqigqqr
|.|..|.||| . ..|.||| ||..      .. ||....|      .....|.| .   ||. ..|.|||..|| .||..| .                
pldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

vtkdfmirtlkatrdkeekifNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNAlqlekidqNFSLYDIIVD
                      |.... .||||||.. . .|.......|..  .. |..|||||| ||.||........          ..||...|  
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaiel

MRKQRHaIVQTRNQYELVHR
.|..|  ||....|.. ...
vrerRp.ivpnpgqlrqLye
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 78-293 1.2e-17 59.0 In-house 36-256 (290) alignment 
Range on Protein: 78-293
Range on HMM: 36-256/290.0
LLSQIDNVEGSDYVNANFLKGAaNDHTYLAAQGPLPH-------TVNEFWRMLWECNTEIIVMACNEFELGRH----KCERYWVD-EGEEHCFGDILVTQ
 | .  .   .||. ||... . |.   .. | |. .       |...|| |  . . . .|| |.  |  ..     |..|  . .|||  |... |  
vLkgygkrfnddyiHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC

iGQQRVTKDFMIRTLKATRDKEE-KIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTaeepPIVVHCSAGCGRTGTICVIDYvrnALQLEK-IDQNFS
  ..   .|. .|.|  . |.||   ..   .  | .  |. . | .|..|. |. ..|    |..|||  |  |  ..  |.    . |.     ....
.kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaiil...gyQkiaetsgsvk

LYDIIVDMRKQRHAIVQTRNQYELVHRAVV
| |.. ..||||   ... ...  |  ..|
ledvlkalrkqralaitsalelafvdagiv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 81-204 8.1e-07 23.4 In-house 6-126 (130) alignment 
Range on Protein: 81-204
Range on HMM: 6-126/130.0
QIDNVEGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACN-EFElgrhkcERYWVDEGE-EHCFGDILVTQIgQQRVTKDFMIR
... ..| .|.||.|.    .   || .| ||  |  .||.|. |   ...|.    | |      . || |    |    ||.||   ..   |     
evsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee......deywpdsePlewyeediivtlt.drdefknikas

TLKATRDKEE--KIFNQFHYTAWPDHGV
 |.  .|  |  . .  |. . ||  | 
nleiesdlneshqaltmfqisnwpsdgt
0046846 (Phosphotyrosine protein) phosphatases II 85-293 4e-44 145.8 In-house 9-170 (176) alignment 
Range on Protein: 85-293
Range on HMM: 9-170/176.0
VEGSDYVNANFLKGAAndhtYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCfgdilvtqigqqrvtkdfmirtlkatr
 ...||.|||.. |..    ..| |||||.|. .|..||.| . ...|. ..|.||||.|| .|| .. ....                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

dkeekifnQFHYTAWPDHGVPTSvKPILDMIKLVREYQTAEePPIVVHCSAGCGRTGTICVIDYVRNalqlekiDQNFSLYDIIVDMRKQRH-AIVQTRN
        |.... |||||||.. . .|......||....   |..||||||.|||||..... ..        ....|.....  .|.||.  .|||..
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqRplgavqtpe

QYELVHRAVV
||. ..... 
Qyrflyefel
0051429 (Phosphotyrosine protein) phosphatases II 86-315 6.5e-48 159.0 In-house 2-244 (272) alignment 
Range on Protein: 86-315
Range on HMM: 2-244/272.0
EGSDYVNANFLKGAAN---DHTYLAAQGPLPHTVNEFWRMlWECNTEIIVMACNEFELGRHKCERYWV-----------DEGEEHCFGDILVTQIGQQrV
. |.|.||....|  .   ........||||.|...|||. .| .   ||. ..|.|.||.||.|||            |. ... .|.. || .  . .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee.l

TKDFMIRTLKAT---RDKEEKIFNQFHYTAWPDHGVPTSVkpILDMIKLVREyqtaeEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKIDQN-----FS
. |...|.| .|     .|   . ..|||.|||||||..   .|....|...     . |..||||||..||||.......   . || | .      . 
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

LYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLGIKPEDYGHNYENVQ
|....  .|.||...|||  ||. ...|..... ..|....| . . .. ..
leeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid
0043147 (Phosphotyrosine protein) phosphatases II 86-289 5e-44 145.4 In-house 3-154 (172) alignment 
Range on Protein: 86-289
Range on HMM: 3-154/172.0
EGSDYVNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEfelgrhkcerywvdegeehcfgdilvtqigqqrvtkdfmirtlKATRD
|||||.||..|..    . ..| ||||..|...|||||.| .  .||.....                                             ...
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

KEEKIFNQFHYTAWPDHGVPtSVKPILDMIKLVRE-YQTAEEPPIVVHCSAGCGRTGTICVIDYVRnalqlekidQNFSLYDIIVDMRKQRHAIVQTRNQ
..|.   |..|. ||||||| . . .|.......| ..  .. |..||||||.|||||........         ...||....  .|..|  .||. .|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnpsq

YELVH
| ...
yrfly
0036282 (Phosphotyrosine protein) phosphatases II 87-289 2.2e-43 143.3 In-house 1-163 (174) alignment 
Range on Protein: 87-289
Range on HMM: 1-163/174.0
GSDYVNANFLKGAANDHTYLAAQGPLPhtvneFWRMLWECNTEIIVMACNEFELGRHKCERYWVDegeehcfgdilvtqigqqrvtkdfmirtlkaTRDK
|||| ||..|..      ..| ||||.     ||.||.| . ...|| ..|.|||..|| .|| .                               .|. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EEKIFNQFHYTAWPDHGVPTSVKpILDMIKLVREYQTA-EEPPIVVHCSAGCGRTGTICVIDYVRNALQlekiDQNFSLYDIIVDMRKQRHAIVQTRNQY
.|.   |..|. |||||||.. . .|...|.|.|..   .. |..||||||.|||||.......   |           .|..  .|.||. .||| .||
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQy

ELVH
. ..
rfly
0051082 (Phosphotyrosine protein) phosphatases II 87-291 5.1e-32 105.9 In-house 2-148 (151) alignment 
Range on Protein: 87-291
Range on HMM: 2-148/151.0
GSDYVNANFLKGAandhtYLAAQGPLPhtvnEFWRMLWECNTEIIVMACNEFELGrhKCERYWVDEGeehcfgdilvtqigqqrvtkdfmirtlkatrdk
 ||| |.... |      ... .|||.    .|...|.| .   ||. ..|.| |  .| .|. ..|                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

eeKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREyqtAEEPPIVVHCSAGCGRTGTICVIDYVRnaLQlekidqnFSLYDIIVDMRKQRHAIVQTRNQYE
    . ..... |||.|.|.| . .|....|...    .. |..||||||.|||||..... .   |.       .||.... ..|..|. .||. .|. 
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleealeeyrlkrpgvvqpnqqfl

LVHRA
....|
fqlfa
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 91-285 4.1e-29 96.3 In-house 78-270 (301) alignment 
Range on Protein: 91-285
Range on HMM: 78-270/301.0
VNANFLKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDE-GEEHCFGDILVTQI-GQQRVTKDFMIRTLK---ATRD
. ||...   . | ..|.||||. | ..|| ||   . | ||| ... |   .||| |   . .|.   |   ..    .. . |. . |||.   .|..
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

KEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREyqtaEEPPIVVHCSAGCGRTGTICVIDYVRNALQlekIDQNFSLYDIIVDMRKQRHAIVQTRNQY
 . .    . |. |.|.||| |   . |...||..     | ||||||||| ||. .    .|. ....    |..  | . . ..|..|   |||..| 
fatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylareve...adptieltealkhlrehrwngvqtnsql
0049260 (Phosphotyrosine protein) phosphatases II 96-289 1.5e-42 140.1 In-house 2-143 (152) alignment 
Range on Protein: 96-289
Range on HMM: 2-143/152.0
LKGAANDHTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWvdegeehcfgdilvtqigqqrvtkdfmirtlkatrdkeekifnQFH
..| |. . ..|.|||.|.|...|||||.| .  .||| ....|||. |||.|.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

YTAWPDHGVPTSVKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRnalqlekidQNFSLYDIIVDMRKQRHAIVQTRNQYELVH
.. |||||||..   .|..........  .. |..||||||.|||||........         ...||....  .|..|  .|.. .|.....
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 103-289 2.5e-14 47.9 In-house 5-197 (199) alignment 
Range on Protein: 103-289
Range on HMM: 5-197/199.0
HTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV-DEGEEHCFGDILVTQIG---QQRVTKDFMIRTLKATRDKEEKIFNQFHYTA
. |.|.| || .|. .||.|.||  .  |||  ..          ||   |     .| . ||      .   |   .| | ..|     .   .. .|.
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPTS---VKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVH
| ..  |     |  ..   .. . |.   . |..|||| | | || .  .|    . .  |      |...   .|. |  |. . ..|....
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 103-289 2.5e-14 47.9 In-house 4-196 (198) alignment 
Range on Protein: 103-289
Range on HMM: 4-196/198.0
HTYLAAQGPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWV-DEGEEHCFGDILVTQIG---QQRVTKDFMIRTLKATRDKEEKIFNQFHYTA
. |.|.| || .|. .||.|.||  .  |||  ..          ||   |     .| . ||      .   |   .| | ..|     .   .. .|.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPTS---VKPILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQLEKiDQNFSLYDIIVDMRKQRHAIVQTRNQYELVH
| ..  |     |  ..   .. . |.   . |..|||| | | || .  .|    . .  |      |...   .|. |  |. . ..|....
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 110-286 5.4e-25 82.4 In-house 98-278 (302) alignment 
Range on Protein: 110-286
Range on HMM: 98-278/302.0
GPLPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDE-GEEHCFGDILVTQIG------QQRVTKDFMIRTLKATRDK----EEKIFNQFHYTA
 |   |.. .| .. . |. |.|  |.  | . .||  |. |. |.|  ||   |. .       .    |.|.. |.. . .|     .|  . ....|
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPTSVKPILDMIKLVREYQTAeeppIVVHCSAGCGRTGTICVIDYvrnALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYE
||||| |   .. ||..|    |...    ..|||||| |||||.  | |    .|| . ..   | .|.. .|. |.  ||. .|  
wpdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaiky...GiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_hpo-7_pd Subfamily hpo-7 112-296 5.5e-18 59.8 In-house 43-227 (263) alignment 
Range on Protein: 112-296
Range on HMM: 43-227/263.0
LPHTVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEG-EEHCFGDILVTQIGQQRvtkDFMIRTLKATR----DKEEKIFNQFHYTAWPDHGVPT
|  |...|....   .|| .|| |.  | |. ||..|.  |  |   . .. |.    |    | ...||. .      |. . .... |. |...  |.
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpe

SVKPILDMIKLVREYQtaeepPIVVHCSAGCGRTGTICVIDYVRN--ALQLEKID-QNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
  . || ..|..|. .     ..|||||.| ||.    |.. |     ..|.. .  ..    .. ..|..|.. ..|  |       |.|..
lareilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 115-296 5.4e-20 66.5 In-house 40-221 (255) alignment 
Range on Protein: 115-296
Range on HMM: 40-221/255.0
TVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEG-EEHCFGDILVTQIGqqrVTKDFMIRTLKATR----DKEEKIFNQFHYTAWPDHGVPTSVK
||..|....   .|| .|| |.  | |. ||..|.  |  |   . |. ||       . | ..|||. |      |. .  . ..|. |...  |   .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

PILDMIKLVREYQtaeepPIVVHCSAGCGRTGTICVIDYVRN--ALQLEKID-QNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
 || ..|.||. .     ..|||||.| ||. .  ....|     ..|.. .  ..    .. ..|..|.. ..|  |  .    |.|..
eilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 115-301 1.8e-07 24.1 In-house 130-314 (346) alignment 
Range on Protein: 115-301
Range on HMM: 130-314/346.0
TVNEFWRMLWECNTEIIVMACNEFELGRHKCERYWVDEGEEHCFGDILVTQIGQ--QRVTKDFMIRTLKATrDKEEKIFNQFHYTAWPDHGVPTSVKPIL
 |..|| |... . ... .   .  |       .  ..|  .  | ... .         |.. |  |    . .  | .  |.. |     |    ||.
fvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpeg.nsdsvicqvhhhapwkhlqqppktlpii

DMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNALQlEKIDQNfsLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMFQAHLG
 ||.     .  ..  . |    ||||. ..    |  | |. . |. |  ...|. ....||   |..  ||  ..  |.|    . |
kmihqflsekqvqnagvcvvslfgcgracsfigalyainqln.ngiepn..iceimknikqqrpggvesfaqyasiyaivfdyiarkrg
subfamily_PTEN_pd Subfamily PTEN 168-268 2.9e-08 28.9 In-house 55-155 (184) alignment 
Range on Protein: 168-268
Range on HMM: 55-155/184.0
QQRVTKDFMIRTLKATRDKEEKIFN-QFHYTAWPDHgVPTSVKPILDMIKLVREYQTAEEPP-IVVHCSAGCGRTGTICViDYVRNALQLEKIDQNFSLY
... .....|  |.. |. ..| |. . . .   ||  | ... . .... ....  ...   .|||| || ||||.. |  |. ..|.||| ..  .|.
ekkhkdhykiynlrserkydskkfdgrvavypfdDh.nppplelleeivediekwleedkknvvvvHCkaGkGRtGvliv.ayllkslllekaeealelf

DII
. .
aea
subfamily_VSP_pd Subfamily VSP 170-245 2.1e-07 25.1 In-house 71-147 (212) alignment 
Range on Protein: 170-245
Range on HMM: 71-147/212.0
RVTKDFMIRTLKATRDKEEKIFN-QFHYTAWPDHGVPTsVKPILDMIKLVREYQTAEEPPI-VVHCSAGCGRTGTICV
. .. . .  | . |. .||.|| . .     || ||. .. .| . | |.|.  ...  . ..||  | ||||||  
khrdhykvvnlcseraydekyfnnrvkriliddhnvpk.leellvftkevkewlekdlknvlaihckGGkgrtGtivc
subfamily_PTPMT1_pd Subfamily PTPMT1 171-285 3.1e-06 21.7 In-house 53-158 (171) alignment 
Range on Protein: 171-285
Range on HMM: 53-158/171.0
VTKDFMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEEpPIVVHCSAGCGRTGTIcVIDYVRNAlqlekidQNFSLYDIIVD
..... ...|  . .. .|   .. . | .|.   .... ... .........  .  . ||| || ||..|. |. |.          ...|. . .  
lneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgk.rvYvHCkaGrgRsatl.vacylmkk.......eklspeeAlka

MRKQRHAIVQTRNQY
..|.|. |   ..|.
lkkkRkiirlakkqw
0048076 (Phosphotyrosine protein) phosphatases II 175-292 1.1e-26 88.6 In-house 31-139 (145) alignment 
Range on Protein: 175-292
Range on HMM: 31-139/145.0
FMIRTLKATRDKEEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEePPIVVHCSAGCGRTGTICVIDYVRNalqlekidQNFSLYDIIVDMRKQ
 .. .|  ... .|.   |..|. |||||||.. . .|.......|.. ..  |..||||||.|||||..... ..         ...||....  .|.|
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsq

RHAIVQTRNQYELVHRAV
|. .|.. .|.. .....
rpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 176-290 2.1e-25 84.5 In-house 32-139 (144) alignment 
Range on Protein: 176-290
Range on HMM: 32-139/144.0
MIRTLKATRDKEEKIFN--QFHYTAWPDHGVPTSVKPILDMIKLVREYQTaEEPPIVVHCSAGCGRTGTICVIDYVRnalqlekiDQNFSLYDIIVDMRK
.. .|  ....|. ...  |.... |||||||.. . .|.......|..  |. |..||||||.|||||..... ..         ...||....  .|.
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrs

QRHAIVQTRNQYELVHR
.|  .|....|.. ...
rrpgavpnpgqlrfLle
PTEN_1 181-244 4.4e-09 31.4 In-house 82-148 (196) alignment 
Range on Protein: 181-244
Range on HMM: 82-148/196.0
KATRDKEEKIFNQFH--YTAWPDHGVPTSVKpILDMIKLVREYQTAEE--PPIVVHCSAGCGRTGTIC
....|.|| . ...      ..|||.|.  . ..|..| . |.  . .    ..||| || ||.||..
grsydleeffksgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 187-325 3e-23 76.8 In-house 87-224 (440) alignment 
Range on Protein: 187-325
Range on HMM: 87-224/440.0
EEKIFNQFHYTAWPDHGVPTSVKPILDMIKLVREYQ-TAEEPPIVVHCSAGCGRTGTICVIDYV-RNAlqleKIDQNFSLYDIIVDMRKQRHAIVQTRNQ
| . ..|.|| .|||.|||  . |.| ||. | | |  | . |..||||||.|||| | ..| . |.|    |  ..  .. .|  ||..|  .||| .|
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilrea....krsdqidifsfinsmrnnrpqmvqtpeq

YELVHRAVVDMFQ-AHLGIKPEDYGHNYENVQLKHEHFEQPR
| .|| ||.. .  .   |  .|  .  |..|    | ..  
yafvheavlegllcgdtliledditerveqiqwpnphtdksp
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 190-297 5.3e-18 59.9 In-house 216-345 (350) alignment 
Range on Protein: 190-297
Range on HMM: 216-345/350.0
IFNQFHYTAWPDHG---VPTSVKPILD----MI---KLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRN-ALQLEKIDQNF-------SLYD----I
.  |...  |.| .    | |. ..|.    .|        ...|. .||.||||||.|||||.. .|.. .  . ||.. ...        . |    |
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

IVDMRKQRHAIVQTRNQYELVHRAVVDMFQ
.  .||||  .||. .|.  .. |.  .|.
vnelrkqrismvqnldqfifiYeallfyfa
PTPc_DSPc_SM00012 192-293 2.8e-32 106.4 In-house 3-104 (105) alignment 
Range on Protein: 192-293
Range on HMM: 3-104/105.0
NQFHYTAWPDHGVPTSVKPILDMIKLVREYQTAEE--PPIVVHCSAGCGRTGTICVIDYVRNALQLEKidQNFSLYDIIVDMRKQRHAIVQTRNQYELVH
...|||.|||||||.....||.... |.. ....|  .|.|||||||.|||||....|.. . |. |.  .......|.  .||||.  ||| .||  ..
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylfly

RAVV
||. 
rall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 192-297 4.9e-15 49.7 In-house 221-345 (349) alignment 
Range on Protein: 192-297
Range on HMM: 221-345/349.0
NQFHYTAWPDHGV---PTS------VKP-ILDMIKLVREYQTAEEPPIVVHCSAGCGRTGTICVIDYVRNAL-----QLEKIDQNFSLYDII----VDMR
 |. .  |.| ..   | |      ||. ..|       ..|.. ....|||||||||||... .|.. . |     .  ||. .  | |.|      .|
lqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelr

KQRHAIVQTRNQYELVHRAVVDMFQ
||| ..||  .|.  .. |..  |.
kqrismvqnlaqfiaiyealLkyfa
0038934 (Phosphotyrosine protein) phosphatases II 192-292 2.8e-11 38.9 In-house 80-173 (194) alignment 
Range on Protein: 192-292
Range on HMM: 80-173/194.0
NQFHYTAWPDHGVPTSVKPILDMIKLVREYQTA-EEPPIVVHCSAGCGRTGTICVIDYVRNalqlekidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHR
 ...   .||.|.. | . .|. ..|| |.  . ..  ..||| || |||||...   .          ...|. . |  .|  |  ........| ...
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr........lgmsaeeAialfrekRpgaipnqdyleallk

AV
 .
ry
subfamily_PTPDC1_pd Subfamily PTPDC1 194-290 2.6e-12 41.5 In-house 85-170 (182) alignment 
Range on Protein: 194-290
Range on HMM: 85-170/182.0
FHYTAWPDHGVPtSVKPILDMIKLVReyQTAEEPPIVVHCSAGCGRTGTICVIdYVRNAlqlekidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHR
..  .|.|.||. |.. |||..|.|   .. .|  . ||| || |||| .    |.  |       ....  . |  .|..|   .|||.| |||. 
vynfgwkDygva.sleriLdivkvva..falqegkvavhChaGlGrtGvliac.ylvya.......krltaekaiklvrskrpksiqtreqvelvke
subfamily_DSP23_pd Subfamily DSP23 200-290 4.1e-07 24.7 In-house 60-140 (148) alignment 
Range on Protein: 200-290
Range on HMM: 60-140/148.0
PDHGvPTSVKPILDMIKLVREYQTAEEpPIVVHCSAGCGRTGTICVIDYVRNalqlekidQNFSLYDIIVDMRKQRHAIVQTRNQYELVHR
.|.  | ... . .....| | .  .|  . |||  | |||||.    .|..        ....  . | ..|..|   |.| .| .||. 
ddyh.ppaleqvvefvrvveeaeekne.avsvhcllgrgrtgtmlacylvke........rklaaaeaiaevrrlrpgsvetveqeklvrd
subfamily_CG42327_pd Subfamily CG42327 224-299 8.3e-12 39.4 In-house 245-317 (319) alignment 
Range on Protein: 224-299
Range on HMM: 245-317/319.0
AEEPPIVVHCSAGCGRTGTICVIDYvrNALQLEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRaVVDMFQAH
 .  |.||||| | ||||..   |   .  .||.  .   . ...  .|..|   |.|..|||.... |. .. ..
esqGPlvvhcsdGvGrtGlviasdi..airsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk.vlseyakk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 229-295 4.5e-08 27.4 In-house 1-64 (69) alignment 
Range on Protein: 229-295
Range on HMM: 1-64/69.0
IVVHCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
.|||||.| |||||.  |      .. ||.     ... .  ||| |  .|   ..| ..| |.|. 
mvvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_eak_pd Subfamily eak 229-296 3.4e-06 20.7 In-house 239-305 (332) alignment 
Range on Protein: 229-296
Range on HMM: 239-305/332.0
IVVHCSAGCGRTGTICVIDYVRNALQlEKIDQNFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDMF
 .. .. |  |.|.  ||| . . .. .|.   .|. |.|. ....|   | .  |. ... .|.| .
piiqsarGsaraGvfvvidllirlid.nkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 230-295 3.3e-08 27.8 In-house 1-63 (69) alignment 
Range on Protein: 230-295
Range on HMM: 1-63/69.0
VVHCSAGCGRTGTICVIDYVRNALQLEKIdqnFSLYDIIVDMRKQRHAIVQTRNQYELVHRAVVDM
|||||.| |||||   |      .. ||.     ... .  ||| |  .|   |.| ..| |.|. 
vvhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdalvea