Gene PTPN13 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN13
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP057_AA protein Get Run
SpurP057_AA_115-392 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 95-394 2.6e-96 317.8 In-house 6-302 (308) alignment 
Range on Protein: 95-394
Range on HMM: 6-302/308.0
NAQLESMAIVRPAEGGRYTGRGLRSSIAKIQKQIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILedSGPSDYINASHIKAQV
.|.|| .. ...     ..   . . . ...|..|..   |||..|..|| . ... |.. .||||||....||||..||.|  ...|||||||...  .
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgys

GKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMN
 | . ..||.|||||||. ||| |||||.  || |.|  || |..||..|||.. ..  ..|... |.| ....||.. .| . . .....|...||.. 
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfh

FATWPDHSVPSTSLPLLRFACHMRRIHdDRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKTV
. .||||.||.   .||.|  ..|. . .  |||||||||.|||||.|..| .| ..... .. |...|| ||.|| ||.||..||.|.|.|.|| ||..
ytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_PTPN3_pd Subfamily PTPN3 117-391 1.5e-84 278.3 In-house 1-275 (280) alignment 
Range on Protein: 117-391
Range on HMM: 1-275/280.0
LRSSIAKIQKQIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGPsDYINASHIKAQVGKDT--YEYIACQGPLPNTTQD
|| |.......... .   .|..| . |   ....|.|..| .|||.|..||||.|||.|..|   |||||.... ..   .    |||.||||..|..|
lresllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatd

FWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSplMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFA
|| |||||.. .| |.|  ||.|.||||.||||. ..  . | ...|..|. ..  .. .| ... |.||.| ....|. .  ||||.||. |  .|.| 
fWqmvweqksslivmlttlverGrvkChqyWPetede..leygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefv

CHMRRIH-DDRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
...|...  .. |.|||||||||||| ||...  | ||.. |.. .|.||. .| ||. ..||..|| |  .| |.. 
ervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 117-393 1.8e-79 262.1 In-house 7-282 (318) alignment 
Range on Protein: 117-393
Range on HMM: 7-282/318.0
LRSSIAKIQKqIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILE---DSGPSDYINASHIKAQVGKDtyEYIACQGPLPNTTQ
|.| ......   .    ||.. | ....     .. .  || |||. |.|.||.||| |.   ..  ||||||..|     |   .|||.|.|||.| .
leshvrrlre.sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkk..ayiaaqaPlpetie

DFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANsplMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRF
||| ||||| . || |.|  .|.||.|.|||||..     . |... | |..  .|... .|.. .  .|..|. .| | ....|||..||. .  || .
DfWrmvWeqnsavivmltqeeergkakvhryWPskgs...rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl

ACHMRRIH--DDRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKT
  . ....   .. |||||||||.||||. |..|..|  |  ..   |...|| ||.||. |.||.|||.|.|.. ||||..
vrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_ptpA1_pd Subfamily ptpA1 118-358 7.9e-41 135.1 In-house 7-261 (418) alignment 
Range on Protein: 118-358
Range on HMM: 7-261/418.0
RSSIAKIQKQIDKQ-DPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVIL---EDSGPSDYINASHIKAQVGKdtyEYIACQGPLPNTTQ
.||| .....|       |||. | .     .  |  | .|  |||. |.|| ..||| |   .|   |||||| .|     |   ..|. |||||||  
kssiynlknhikcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk...qfictqgplpntia

DFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANS-PLMVYN-------RIEVR-LENYQNLDNFSIRRILMIDNEtSEVHHVTQMNFATWPDHSVP
||| ||||.|. .| |.. . |  ..|| |||||      . .|           |  .|  |. .   | | . .  |  | . .|| ..  |||| .|
dfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe.getrditqyqyegwpdhnip

STSLPLLRFACHM--R--R---IHDDRLPIVVHCSAGIGRTGTLITidAILGLIDRDEEFK
  . |. ..   .  |  .     |  .||.||||||.|||||. |  |.. .   |  ||
dhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct..avimmkkldhyfk
subfamily_PTPRD_pd Subfamily PTPRD 120-393 2e-91 302.4 In-house 13-283 (564) alignment 
Range on Protein: 120-393
Range on HMM: 13-283/564.0
SIAKIQKQiDKQDPAEEFKTLRQVkAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILE---DSGPSDYINASHIKAQVgkDTYEYIACQGPLPNTTQDFW
 .||.... ....  ||.|....     ..|.|.| .|| |||. |...||..||.|.       |||||||.|..       .||| ||||..|..|||
hvaklkan.sdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFW

LMVWEQRADVIAMVTMDVESGKVKCHRYWPESaNspLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACH
 |||||.  .| |.|  .|.||||||.||||. .     |....| ||. ..| ...|| . . ....||.. |.| .|  |||| || .  .||..  .
RmvweqnsstiVmltkleEkgkvkchkYWPek.g..tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirk

MRRIHD-DRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKT
.|...  |. |||||||||.||||| |.|||.|  |  ..   . ..|| |||||. |.||..||||...| ||||. 
vralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
0039614 (Phosphotyrosine protein) phosphatases II 120-393 8.4e-81 267.0 In-house 21-291 (297) alignment 
Range on Protein: 120-393
Range on HMM: 21-291/297.0
SIAKIQKQIDKQDPAEEFKTLRQVKAidNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGP----SDYINASHIkaQVGKD-TYEYIACQGPLPNTTQD
 . .. |. .|.   .||..| ..|   ....|.. .||||||....|||| .||.| . .     |||||||..  .. .  | ..||.|||||.|. |
lllllekansktllllefeellslkp..dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlpetved

FWLMVWEQRADVIAMVTMDVESGKvKCHRYWPESANsplmVYNRIEVRLENYQNLDNFSIRRILMIDneTSEVHHVTQMNFATWPDHSVPSTSLPLLRFA
|| |||||.  || |.|  || |. ||..||||. .    .|... |.| ... ||.. .| . . .  ..|...||.. .  ||||.||...  ||.| 
FwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefl

CHMRRIHD---DRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKT
  .|...    .  |..||||||.|||||.|... .| ....  .. ||..|| ||.|| |..|| .||.|.|.|.|| ||.
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
subfamily_Ptp69D_pd Subfamily Ptp69D 120-390 1.7e-66 219.4 In-house 12-285 (307) alignment 
Range on Protein: 120-390
Range on HMM: 12-285/307.0
SIAKIQKQIDKqDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILED---SGPSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFW
.. . ... |    |.|...| . .   ... ..|  |. |||. .. ..|||||.|.    .  |||||||.||.   |.. ..|| |.|. .| .|||
alksrkrdtdf.glakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgy..kekkkfiaaqdPveatigDfW

LMVWEQRADVIAMVTMDVESGKVKCHRYWPESansPLMVYNRIEVRLENYQNLDNFSIRRIL--MIDNET---SEVHHVTQMNFATWPDHSVPSTSLPLL
 |..||   .| |..   |  . ||..|||.      . |. | |.| . .. ... || .   ....|.    . ..|.| .. .|.|  || ..  ||
RmiaeqevtlivmlsnlteknrkkcakYWpie...devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargll

RFACHMRRI-HDDRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEA
..  ..| . . .| ||||||||| ||.|.....| .|  .  ... .. ..||.||.||. ..|  .||.|.|.| |. 
klieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPN13_pd Subfamily PTPN13 121-394 1.1e-147 485.6 In-house 1-272 (273) alignment 
Range on Protein: 121-394
Range on HMM: 1-272/273.0
IAKIQKQIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGPsdYINASHIKAQVGKDTYEYIACQGPLPNTTQDFWLMVW
||..||..|.|.||||||.||..|..|.||..||..||||||.|||||||.|||.|.|.|.  |||||.||..||||.|||||||||||.|..|||.|||
iaalqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvw

EQRADVIAMVTMDVESGKVKCHRYWPESANSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRI
||.|.||||||...|.||||||||||||.|..|.|.||.||.|...|.||.|..|.. ..|.|..|...|...||..||||.|||....||.|....||.
eqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl

HDDRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKTV
..|..||||||||||||.|||||||..||||.||.||.| .||. ||.||||..||||||||.|||.||.||..
qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlksl
subfamily_PTPN6_pd Subfamily PTPN6 121-389 3.1e-79 261.1 In-house 16-295 (306) alignment 
Range on Protein: 121-389
Range on HMM: 16-295/306.0
IAKIQKQIDKQDPAEEFKTLRQV--KAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVIL-EDSG-PSDYINASHIKAQVGKDTYEYIACQGPLPNTTQDFW
. | .....|..  |||..|.|   |   . .|..|..|| |||..|.||.|.||||| |.|   ||||||. || .| . . .||| || |..| .|||
lekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

LMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSPLmvYNRIEVRLENYQNLDNFSIRRILMI-DNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFAC
 |||.. . || |.|..|| || || ||||.. ...   | .|.|.  . ..|... .|....   .. .| ..| |..| .||||.||.    .| |  
rmvwqensrvivmttkevErgkekCarYWPdeeekee..yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfle

HMRRIHDDRL-----PIVVHCSAGIGRTGTLITIDAILGLIDR---DEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
...| ...       |||||||||||||||.| ||..| || .   | .. . ..|| .|.||.|..||..|| | |||  .
dvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 122-393 1.4e-77 255.9 In-house 18-292 (298) alignment 
Range on Protein: 122-393
Range on HMM: 18-292/298.0
AKIQKQIDKQDPAEEFKTLRQVKA---IDNCEEAKKAQNKDKNRFRNVLPYDKTRVILED---SGPSDYINASHIKAQVGKDtyEYIACQGPLPNTTQDF
|...|. .    |.||..|..|.     .. | |.| .||.|||. .....|..||.||.      |||||||...|  |..   .||.|.||..|..||
aavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedF

WLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSplmVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFAC
| ||.|. . .| |.|  .|..|.|.|.|||.. .     |..|.|.| . ..  .. .|.. . ...... ..| |..| .|||..||...  .| .  
WrmvteedigtiVmltnleeldktkyhkywPdegke...tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllr

HMRRIHDDRL--PIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKT
..|. . .    |..|.||||.||.|| | ||..|  . ...   |...|| |||.| |..||..||.|.|.| ||||..
kvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 123-393 1.1e-76 253.0 In-house 16-285 (319) alignment 
Range on Protein: 123-393
Range on HMM: 16-285/319.0
KIQKqIDKQDPAEEFKTLRQVKAIdNCEEAKKAQNKDKNRFRNVLPYDKTRVIL---EDSGPSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMV
....   ..  ..|||.|.. ..  . ..|.| .||.|||..|.|.||.|||.|   ...  |||||||.| .   ..  ..|| |.|| ||..||| ||
alas.tgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy..qerekfiatqaPlentiedfWrmv

WEQRADVIAMVTMDVESGKVKCHRYWPESAnspLMVYNRIEVRLENYQNLDNFSIRRILMiDNETSEV--HHVTQMNFATWPDHSVPSTSLPLLRFACHM
||... .. |.| .|| .|||...||||      ..| |. | ||. ..|... ||.. . .. .|||   .|..  .  |||| || ... || .  ..
Weeessivvmltklveklkvklkkywpeen...feeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkri

RRIHDD--RLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKT
|. ..     |||||||||.||||| |..||.|  . ...   | ..|. || ||. |.|...||.|.|.| |||...
rksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 123-392 3.4e-64 211.8 In-house 18-285 (297) alignment 
Range on Protein: 123-392
Range on HMM: 18-285/297.0
KIQKQIDKQDPAEEFKTLrqVKA-IDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDS---GPSDYINASHIKAQVGkdtyEYIACQGPLPNTTQDFWLM
 .||. . .   |||. |   .| | .   |.|  | .|.|..|.||||. ||.|.       |||.|||..|..      ..|. | | ..| .||| |
lvqknrhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWam

VWEQRADVIAMVTMDVESGKvKCHRYWPESANSPlmvYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPS--TSLPLLRFACH
|..... .|.|.. | |. | || |||.... ..   .  . | |.  ..   |. | . .  ...   . | | .|  |||..|.   .   || .   
vldeqvstivmlnddnerdk.kcaryWsdkgvtt...fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklise

MRRIHDDR--LPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
.|  ....   |..|||.||.|||| |.||| ..  . |..|  ....|| ||..|  ..|||.|| | |.| |||| 
vrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 123-391 1.8e-26 87.3 In-house 18-285 (302) alignment 
Range on Protein: 123-391
Range on HMM: 18-285/302.0
KIQKQIDKQDPAEEFKTLRQVKA-IDNCEEAKKaqNKDKNRFRNVLPYDKTRVILEdSGPSDYINASHIKaqVGKDTYEYIACQGPLPNTT---QDFWLM
|. |..|..   .|||.. ..|. ...|.  ||  | .||.  .|  .|...|.||   | .|.|||...  | . |.. |  | |  ...   ..|| |
klvksldtaevkkefkkidtmkvdlekCkafkk..nlkknqsedvpildsnlvkle.aepdsyvnaskve..vPeltrsiilaQlpkvdsedsveeFWrm

VWEQRADVIAMVTMDVESGKvKCHRYWPESANSpLMVYNRIEVRLENYQNL----DNFSIRrilMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFA
|....   . .. .. |  |   . ..|. ...    |... |     ..     ....|    .. .. |.   ..   .  |....||     | . |
vfqekivsvvilvgeeelkk.tlselfpkksgd.ykeygkmfvNnrkVekaeeektryviE...vlPegcsnsvlanvyvltnWkqkkvpvkyaelikta

CHM-RRIHDDRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
 ..  .  .   ..|.    |.|| |...|  . .  .....| .. .||| .|.||  .... .||.. | |.|  .
akvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
0047943 (Phosphotyrosine protein) phosphatases II 124-391 1.2e-88 292.5 In-house 5-272 (273) alignment 
Range on Protein: 124-391
Range on HMM: 5-272/273.0
IQKQIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILeDSGPSDYINASHIkaQVGKDTYEYIACQGPLPNTTQDFWLMVWEQR
..|. ...  .|||..|...| . ... |.. .||||||....||||..||.| ..|.|||||||..  .. . . ..||.|||||||. ||| |||||.
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwrmvweqn

ADVIAMVTMDVESGKVKCHRYWPESANSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHD-
. || |.| .|| |..||..|||.. ..  ..|... |.| .... |.. .| . . ...|.|...||.. . .||||.||..  .||.|  ..|...  
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--DRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
  .  |.|||||||.|||||.|..| .| .. .  .. ||..|| ||.|| ||.|| .||.|.|.|.|| |
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 124-393 1.1e-86 286.1 In-house 6-279 (297) alignment 
Range on Protein: 124-393
Range on HMM: 6-279/297.0
IQKQIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILeDSGPSDYINASHIkaQVGKDTYEYIACQGPLPNTTQDFWLMVWEQR
. |.....   .||..| ..... ... |.. .|..|||....||||.|||.| |...|||||||..  .. . ....||.|||||||. ||| |||||.
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmvweqn

ADVIAMVTMDVESGKVKCHRYWPESANSPLMvYNRIEVRLENYQN--LDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIH
  || |.| .|| |..||..|||.  ...|  |... |.| ...   ||.. .| . . |....|...||.. . .||||.||..  .||.|   .|...
vtvIvmltelvelgrekcaqywpleegeslt.ygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

D---DRLPIVVHCSAGIGRTGTLITIDAILGLID---RDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKT
.   .  |..||||||.||.||.|..| .| ...   . ... .|..|| ||.|| |..|| .||.|.| | || ||.
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_PTPN14_pd Subfamily PTPN14 124-392 1.7e-65 215.9 In-house 16-297 (300) alignment 
Range on Protein: 124-392
Range on HMM: 16-297/300.0
IQKQIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDS--GPSDYINASHIKAQVGKDTYEYIACQGPLPNTTQDFWLMVWE
..|....     |.  . . ..  ... ||  .|..||||..||||...|| |  .    ..|||||.||..||  ...||..||||..| |||| ||||
lekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWe

QRADVIAMVTMDVESGKVKCHRYWPES-ANSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHM---
|  ..|.|.| . |.|| |...|.|..  .   . ... .|  .  .. | .  . . .    ..|   |  . .. |||| ||.   . | .  ..   
qgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsv

RRIHD-------DRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
||  .        . |..||||||.|||| ||. | ..  .. .|| .. .... ||.||. ..||  || | ||. .. ||
rrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0040438 (Phosphotyrosine protein) phosphatases II 125-393 6.3e-87 287.1 In-house 12-278 (317) alignment 
Range on Protein: 125-393
Range on HMM: 12-278/317.0
QKQIDKQDPAEEFKTLRQVKAIdNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGP---SDYINASHIkaQVGKDTYEYIACQGPLPNTTQDFWLMVWE
 .. |.. . |||..|...|   ....|.. .||||||....|||| .||.| . |.   |||||||..  .. . . ..||.|||||||. ||| ||||
llksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrkfIatqgPlpntvedFwrmvwe

QRADVIAMVTMDVESGKVKCHRYWPEsanSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIH
|.  || |.|  .| |..||..|||.      ..|... |.| ... |... .|.. . |...||...||.. . .||||.||..  .||.|   .|.  
qgvtvivmLteleelgrekcaqYwpl...getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

DD-RLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKT
.|   |..||||||.|||||.|... .| .... ... | ..|| ||.|| |..|| .||.|.|.|.|| ||.
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 125-389 1.5e-78 258.8 In-house 15-277 (288) alignment 
Range on Protein: 125-389
Range on HMM: 15-277/288.0
QKQIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILED---SGPSDYINASHIKAQVGKdtYEYIACQGPLPNTTQDFWLMVWE
... ....  ||...| ...  .. . ...|.|..|||.||.|||| .|| |..      .||||||.|. . .|   .||| ||||..| .||| .|.|
ksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkk..kkyiatqgPladtvndfWelvye

QRADVIAMVTMDVESGKVKCHRYWPESANSplMVYNRIEVRLENYQNLDNFSIRRILMIdnETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIH
...  |.|.|  || || ||..|||.. .     |  ..| | . ..|..|  |..|.    . .  ..||... .||||.||  . ||| .   .   .
nktstivmltelveggktkCeeYWPdadkp..knyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvan

DDR-LPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
..   ||.||||||.||||| |..||..  .....   |...|. |||||. ..||. ||.|.|.. |.
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPN9_pd Subfamily PTPN9 125-389 2.3e-67 222.1 In-house 10-288 (297) alignment 
Range on Protein: 125-389
Range on HMM: 10-288/297.0
QKQIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILE---DSGPSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWE
 |. .|.   .|.. .|. ..  . . .|.  |  |||. .|| ||.||| |.   .   ||||||...     |    .|| ||||..|..|||.||||
vkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy..kqkkafiatqGplkktvsdfWrmvWe

QRADVIAMVTMDVESGKVKCHRYWPESANSpLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRR--
|.. || |.|  || |..|| .|||.. .|  . .  ..|.  . .. ... .| . . . .|.|  .||   | .|||. |||..  || .  ..|.  
qevlvivmttrvvergrlkcgqyWpleees.saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

------------IHDDRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
             | .  |||||||||||||||.||.|  |  ... .  .| . || ||.||  .||| .|| |||.| ||
alavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 125-391 5.1e-56 185.2 In-house 17-288 (325) alignment 
Range on Protein: 125-391
Range on HMM: 17-288/325.0
QKQIDKQDPAEEFKTLRQVKAIDNcEEAKKAQNKDKNRFRNVLPYDKTRVILE---DSGPSDYINASHIKAQVGKDTyeYIACQGPLPNTTQDFWLMVWE
.|  |..  | ||. |  . .|   . | | .||.||||.||...||.||.||   |.. |||||||... ...||.  ..|.| ||..|..|.| .| .
kkaqdqdgfahefgllpsddgiak.kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdv..flaaqaPltatindlWrlvld

QRADVIaMVTMDVESGKVKCHRYWPESANSPlMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSV---PSTSLPLLRFACHMR
 |. |. .|.  .. || .|  |||.        .  .||.|   ... ..  |.. . . .  |   | |... .|.|  |   |.| ...|.   .. 
Wrcsvv.vvlneldlgkdrcavywpkemgks.ktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs

-RIHD---DRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
 |..       ||.||||||.||||..|.. ..|  .  . .  ... || |||.|  |..| ||||..|.|  ||.
ervtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 126-395 3.1e-80 264.3 In-house 10-280 (281) alignment 
Range on Protein: 126-395
Range on HMM: 10-280/281.0
KQIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVIL---EDSGPSDYINASHIKAQVGKDtyEYIACQGPLPNTTQDFWLMVWEQ
.| |..  .||...|...   .  . .|. .|. |||..|.  ||.||| .   |..  .|||||.....  |.   ||||.|||.|.. ..|| |||||
sqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgek..eyiatqgPvPaslvafWqmvweq

RADVIAMVTMDVESGKVKCHRYWPESANspLMVYNRIEVRLENYQNLDnFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHD
....|.||| ..|.||.|||||||. ..   . |  . |. .. ..    .|.| .....|..|  .|.|... .|||| ||.|.  || |   ......
kvsaivmvtreieagklkChrYWPddns..elkygdvtvkstaeeeka.tyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlklte

DRL--PIVVHCSAGIGRTGTLITIDAILGLIDRD-EEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKTVL
 .   |.|.|||||.||||| |..| ..  .... || .| ..|. |||.|. |.||  || | ||| |.||.  |
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_PTPRA_pd Subfamily PTPRA 126-389 2.5e-71 235.2 In-house 27-293 (330) alignment 
Range on Protein: 126-389
Range on HMM: 27-293/330.0
KQIDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILED---SGPSDYINASHIKAQVGKDtyEYIACQGPLPNTTQDFWLMVWEQ
.  | .   |||..|   .    .| |.| .||.|||. |.|||| .||||        |||||||.|.    ||  ..||.|||. .| .||| |.|||
saddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd..kfiaaqGPkeetvedfwrmiweq

RADVIAMVTMDVESGKVKCHRYWPESAnspLMVYNRIEVRLENYQNLDNFSIRRILMI--DNE--TSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMR
..  | |.|   |  . ||..|||.     |. |  | | .|. . | ....| .|.    ..    ..  |.|. | .|||  ||...  .|..  ...
ksativmltelkerkeekcaqywPdeG...lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk

RIHDDR-LPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
....    |||||||||.|||||.|..||.|  .  ..   | ..|| ||.||  |.||. || |.||. ||
klnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 126-393 1.5e-66 219.6 In-house 17-285 (305) alignment 
Range on Protein: 126-393
Range on HMM: 17-285/305.0
KQIDKQDPAEEFKTLRQVkaIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSG---PSDYINASHIKAQVGKDtyEYIACQGPLPNTTQDFWLMVWEQ
. .....  ...|.| .    . ..  || .|| |||.... ..|. |.||  .     |||||||....  .|.  .||. ||||.|| .||| ...| 
rvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkk..kyivaqgPlkntvadfWrlivee

RADVIAMVTMDVESGKVKCHRYWPESANSPLMvYNRIEVRLENYQNLDNFSIRRILMI-DNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIH
.  .| |.|  || || ||..||||| . .   .....| |.. ..  .. .|.. .  ..| .| . |.|... .|||| || ..  ||..  .... .
kvstivmltklveggkdkCrqYWpesktekke.fgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdq

DDR--LPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKT
      |..||||||.||||. |..|  |  . ..|.  | ...| ||..| .|.||.||| |.. |  | ...
kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 128-389 4e-34 112.5 In-house 8-267 (281) alignment 
Range on Protein: 128-389
Range on HMM: 8-267/281.0
IDKQDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILED----SGPSDYINASHIKAQVGKDTyeYIACQGPLPNTTQDFWLMVWEQR
.  .|  .||  |      | |   ..  |. |||. |.   | .|| |.        .||| | .|.. . |    ||  |||  .|  ||| |.|.. 
mtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg..yiltqgpkketradfwrmiwqen

ADVIAMVTMDVESGKVKCHRYWPESANSPLmVYNRIEVRLENYQNLDNFSIRRIlMIDNEtSEVHHVTQMNFATWPDHSVPSTSLPLLRFachMRRIHDD
.  | |.   .|. . ||  |.|  |   |  .... |  |.      .   |.  .  |  | . .|.  .  |||  || .|  .|.    .|.|.  
ttaivmlcqfletnrekcaeyfprnahccl.qfdklsvsyedstvnkslvttrl.nlsye.getrlithwlwkewpdwqvpessevmlki...lrkirar

RLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEF-KVLNIVKGLRK-QRQGMIQTKDQYIFCYKAALE
  | |.|||||.||.|||....  |  |     .  . .||  ||   |   .|| .||.. .|  |.
stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 130-391 1.8e-43 143.4 In-house 14-293 (301) alignment 
Range on Protein: 130-391
Range on HMM: 14-293/301.0
KQDPAEEFKTLRQVKAiDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSG-----PSDYINASHIKAQVgkDTYEYIACQGPLPNTTQDFWLMVWEQRA
... .|..|.|....  ..|.   . .||  |||.|. .||. |.||.          .|||||.|..    .. ..|| |||. .| .||| ..|... 
snkfeeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys..ekkkfiaaqgpmkktlvdfWrliwqekp

DVIAMVTMDVESGKVKCHRYWPESANSPLMvYNRIEVRLENYQNLDNFSIRRILMIDNETS---------------EVHHVTQMNFATWPDHSV---PST
  | |||   |. | ||..|||.| ..    .  ..| | | |.. .| ||.. .. ...|               . ..|.|.. . ||.. |   | |
vsivmvtnlkegtkskceqywpnseaesee.fgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

SLPLLRFACHmRRIHDDRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
 |  .    | |.   .  |.|||||....|.|. ....  |    ..    | ...| .|... |...| .||.. |..  . |
vLqviddvih.rqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
0045450 (Phosphotyrosine protein) phosphatases II 131-391 4.1e-82 271.6 In-house 27-304 (307) alignment 
Range on Protein: 131-391
Range on HMM: 27-304/307.0
QDPAEEFKTLRQVKA--IDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSG----PSDYINASHIKA------QVGKDTYEYIACQGPLPNTTQDFWLM
.  ..||..|..|.   ......|.. .||||||....|||| |||.| . .    .|||||||...       .. . . ..||.|||||.|  ||| |
tgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrm

VWEQRADVIAMVTMDVESGKVKCHRYWPESanSPLMVYNRIEVRLENYQNLDNFSIRRILMIDN-ETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHM
.|||.  || |.| .|| |..||..|||..  .  ..|... |.| ... ||.. .|.. . |. .|.|...||.. . .||||.||..  .||.|   .
lweqgvtvivmltelvelgrekcaqywPde..geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RRIHD---DRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEE---FKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
|....   .  |..||||||.|||||.|... .| .......   . .|..|| ||.|| |..|. .||.|.|.|.|| |
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 131-392 3e-58 192.1 In-house 20-279 (287) alignment 
Range on Protein: 131-392
Range on HMM: 20-279/287.0
QDPAEEFKTLRQV-KAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGPsDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAM
..  . |..| || .  |.   .   |||||||....|..|. ||.|..  | |||||..|..   |. ...|....|. || ..|| ......  .| |
egfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehp.dyinavfidgy..kekkafiiaesPmfntarnfWkliddrnvtaivm

VTMDVESGKVKCHRYWPESANsplMVYNRIEVRLENYQNLDNFSIRRILMI-DNETSEVHHVTQMNFATWPDHS-VPSTSLPLLRFACHMRR-IHDDRLP
.. . |. . .|..||||...   .|.   ...| | .  ... .|.. .. .|.... ..|.| ....|...  |..    || .   ..   .  . .
lcqekendeevcyqyWpeeks...vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnts

IVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
||||||...||..... ..  .   ...    |....|  | |. |..|| .||.| ... || |.
ivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_CG42327_pd Subfamily CG42327 131-313 2.6e-30 100.2 In-house 5-186 (319) alignment 
Range on Protein: 131-313
Range on HMM: 5-186/319.0
QDPAEEFKTLRQVKAIDNceeAKKAQNKDKNRFRNVLPYDKTRVILEDSGPS---DYINASHIKAQVGKDTYeYIACQGPLPNTTQDFWLMVWEQRADVI
.| ||||. | |. |  .   .  .  |||.|. ||.|  .|||.|.  |      |..||... .   ... |||.| .| ... ||| .||||.. ||
edvaeefrdlPqliarad...evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapns.yiaaqvsledsssdfwrtvweqqsrvi

AMVTMDVESGKVKCHRYWPESANSPL-MVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFaTWPDHSVPSTSLPLLRF
  .|   | |  .| .|.| ..  .   .|  | | | . .  |.. |  .|.   . .|  ..|   .  |..  ||.   .|.  
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 131-206 5.6e-11 36.5 In-house 23-95 (95) alignment 
Range on Protein: 131-206
Range on HMM: 23-95/95.0
QDPAEEFKTLRQVKAIDNCEEAKKAqNKDKNRFRNVLPYDKTRVILEDSGPSDYINASHIKAQVGKDTyeYIACQG
|.  .|||..           . .| |  |||| |..||| |||.|     ||||||  .     |.   |||.||
qefdnefksismtsgapytvgssea.nipknrflnifpydatrvvlttkrdsdyinacfvdgyarknc..yiaaqg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 131-192 4.2e-07 23.8 In-house 13-76 (244) alignment 
Range on Protein: 131-192
Range on HMM: 13-76/244.0
QDPAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDS--GPSDYINASHIKA
.   |||  | .        .|  . |  |||. |.||.|.|||||  |    ||||||..|..
evakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilssskkegsdyinanyiqg
0043336 (Phosphotyrosine protein) phosphatases II 132-390 5.1e-80 264.2 In-house 21-276 (278) alignment 
Range on Protein: 132-390
Range on HMM: 21-276/278.0
DPAEEFKTLRQVKAiDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGP---SDYINASHIkaQVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIA
   .||..|...|  |... |.. .||||||....|||| .||.|.. |    |||||||..   . . . ..||.|||||.|. ||| ||||..  .| 
llllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwelgvttiv

MVTMDVESGKVKCHRYWPesanSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHD-DRLPI
|.| .|| |.|||..|||    .  ..|... |.| ... ||.. .| . . .. ..|...||.. .  ||||.||..  .||.|   .|.. . .  |.
mLtelvelgrvkcaqYwp....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

VVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEA
.||||||.|||||.|... .| ....  .. ....|| ||.|| |..|| .||.|.|.|.|| 
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPN12_pd Subfamily PTPN12 132-395 9.9e-78 255.9 In-house 9-281 (290) alignment 
Range on Protein: 132-395
Range on HMM: 9-281/290.0
DPAEEFKTLRQVKA------IDNCEEAKKAQNKDKNRFRNVLPYDKTRVILED---SGPSDYINASHIKAQVGkdTYEYIACQGPLPNTTQDFWLMVWEQ
. |.||..|.....      . . |...| .|. |||....|||||.|| |.    .  ||||||..||   |  . |||| |||||.| .||| |.||.
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg..kleyiaaqgPLpktlddfWrmiwek

RADVIAMVTMDVESGKVKCHRYWPESANSPLmVYNRIEVRLENYQNLDNFSIRRILMIDNEtSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHD
.  .. |. . || || ||.|||||. ...|  .. .|| ||. ...|.  . | | .... .| ..|.|...  |||| |||.  .||..  ..|....
nveivvmaCrevelgkkkCerYWpeegeeel.efgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

-DRLPIVVHCSAGIGRTGTLITIDAILGLIDR---DEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKTVL
 .  |.|||||||.|||||.|.|| .  |. .   .||..| ..|  |||||. ..|||.|| . ||| .| ... |
sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel
0051299 (Phosphotyrosine protein) phosphatases II 133-391 3.3e-87 287.9 In-house 25-286 (288) alignment 
Range on Protein: 133-391
Range on HMM: 25-286/288.0
PAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGP---SDYINASHIkaQVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAM
 .|||..|.....  ..  |.. .|..|||....||||..||.| . ..   |||||||.|  .. . . ..||.|||||||. ||| |||||.  || |
lleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi..dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvm

VTMDVESGKVKCHRYWPEsanSPLMVYNRIEVRLENYQNLDNFSIRRILMIDN----ETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHD-DR
.|  || |..||..|||.   .  ..|..| |.| ... ||.. .| . . ..     ..|...||.. . .||||.||..  .||.|  ..|. .  . 
ltklvelgrekcaqYwpl...ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgg

LPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
 |.|||||||.|||||.|..| .| .... ... ||..|| ||.|| ||.|| .||.|.|.|.||.|
gpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 133-392 3e-85 280.8 In-house 27-286 (293) alignment 
Range on Protein: 133-392
Range on HMM: 27-286/293.0
PAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVIL---EDSGPSDYINASHIKAQVGKdtYEYIACQGPLPNTTQDFWLMVWEQRADVIAM
 .||...|..|.   ... |..|.|..|||..|.||||..|| |   .|.  ||||||..|. .  .   |.||.|||||.|..||| ||||... .| |
fseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp..refiatqGPlpetvddfWrmvwekkssiivm

VTMDVESGKVKCHRYWPESANSplMVYNRIEVRLENYQNLDNFSIRRILMIDneTSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIH---DDRLP
.|  || |||||..|||.  ..  ..|  |.| | . ..|... || ...    ..| ..|.|..| .|||| ||... .||.|  ..|. .    .. |
ltqlvekgkvkCeeYWPadeep..vlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrP

IVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
||||||||.|||||.|..| .|  |....   .. ||  ||..|. ..||..|||| ... |. |.
ivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 133-393 4.2e-58 191.5 In-house 22-285 (290) alignment 
Range on Protein: 133-393
Range on HMM: 22-285/290.0
PAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILE-DSGPSD----YINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWEQRADVI
  ..||.| . .   . . .   .|| .|||.|...||  |..|   ||  |    ||||..||    |. ..||| |||..||  ||| ..|...  .|
frnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy..kekkqyiatqgpvsntlvdFWkliwqekvtii

AMVTMDVESGKVKCHRYWPESaNSPLmvYNRIEVRLENYQNLDNFSIRRILMIDNET-SEVHHVTQMNFATWPDHS-VPSTSLPLLRFACHMR-RIHDDR
 |.|  .|.|||||. |||.| ..    |. ....| | ..|... .|.. . ....  . ..||| .. .|...  |. ..  || ..  .. . .. .
vmltniieegkvkCqqYWpds.dtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgn

LPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKT
 .||||||...||........  .     .    |....| .| |. |..||..|| . ..  |..|..
tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPRN_pd Subfamily PTPRN 133-395 1.5e-55 183.0 In-house 31-296 (297) alignment 
Range on Protein: 133-395
Range on HMM: 31-296/297.0
PAEEFKTLRQVKAIDNCE-EAKKAQNKDKNRFRNVLPYDKTRVILEDS---GPSDYINASHIKAQVGKDTyEYIACQGPLPNTTQDFWLMVWEQRADVIA
 ..|...| . .| ....  ||. .| .||| ..|||||..|| |...     ||||||| |  .  . .  |||.||||..|  ||| ||||| . || 
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap.ayiatqgplastvadfwqmvweqGvvviv

MVTMDVESGKVKCHRYWPESANSplmVYNRIEVRLE-NYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDDR-LP
..|   |.|  .|.||||.  ..   ||.  ||.|  ..   |.. .| . . . .|||   |||. | .||...||... .|| |   . . .  |  |
nltrleeegvkqckrywpdeGse...vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscp

IVVHCSAGIGRTGTLITIDAILGLIDRD-EEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKTVL
||||||.| ||||. | || .|  . .   |  .   .. || ||.|...||||. |...|  | ....|
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 133-392 3.7e-50 165.7 In-house 22-280 (439) alignment 
Range on Protein: 133-392
Range on HMM: 22-280/439.0
PAEEFKTLRQVKAIDNCEEAKKAQNKD--KNRFRNVLPYDKTRVIL-EDS--GPSDYINASHIKAQVgkDTYEYIACQGPLPNTTQDFWLMVWEQRADVI
  |.|...  ..   .|. .  ||. |  |||...| ..| |||.| |      | |||| .||     |   |||.|||  .||.||| .|.|...  |
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy..ddklyiatqgpkkettddfwrlviekktvti

AMVTMDVESGKvkchrYWPESANsplMVYNRIEVRLENYQNLDNFSIRRILMIDN--ETSEVHHVTQMNFATWPDHSVPSTSLPLLRF--ACHMRRIHDD
 |.|  ||| |     ||| .|.   ..|  | || .   .| |. || . ....   |   . | |. . .|||. ||. .  .| |  |      ...
vmltnlvesyk.....ywpsdae...vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkee

RLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
  |.|||||||.|||||.|..|  |  .  ...  .  ||| |||||. |.|.  ||.| |.| || ..
ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 133-389 4e-42 139.0 In-house 24-285 (305) alignment 
Range on Protein: 133-389
Range on HMM: 24-285/305.0
PAEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGPSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTM
  .||....... ..  .  |.||...|||...|   |. || || . | .|| | .. .    ..  .| .| || .|  ||| | .... . | |.  
lraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstp..tnpkrfictqaplektcadfwymclqdkveaifmlcn

DVESGKVKCHRYWPESAnSPLMVYN----RIEVRLENYQNLD------NFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIhd
 .| |  ||. |..     . . ..    .| |..|  ..|.          . .|.|.   .....||.  .  |||  ||.. | .| .  . |    
llekgakkcleyfaskd.kdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps..

dRLPIVVHCSAGIGRTGTLITIDAILGLI-DRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
 . ||||||||||||||... .. ||  .   .   .   |.. .|.||.  ||| .||.| ..  |.
.kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 133-389 4.8e-42 139.0 In-house 18-275 (307) alignment 
Range on Protein: 133-389
Range on HMM: 18-275/307.0
PAEEFKTLRQVKAIDNCEEAKKAqNKDKNRFRNVLPYDKTRVILEDSG-PSDYINASHIKAQVgkDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVT
  .||. | . .      || .| | ||||...|   ||.|.... .|  |||| | ..   .  .   .|..|||| || ..|| |. ... . . |. 
lvdefrvlakktpegvtveafsa.ntdknryqdvkcqdkgrivvkfdglasdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesvimlc

MDVESGKVKCHRYWPESANSPLMVY-NRIEVRLENY--QNL--DNFSIRRI-LMIDnETSEVHHVTQMNFATWPDHSVPSTSLPLLRFachMRRIHDDRL
  .| .|.||..|||      |.   .   . ..|   ..|  |.  |    | .|  ...   ......  |||. || . |  . .   .  .. |. 
kvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvd.waqksrtiqhlqwenwpdrgvpqinltainl...leavrydtn

PIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKV-LNIVKGLRKQRQGMIQTKDQYIFCYKAALE
|.|||||||.||.||...|  .   . . .. |   ..|. ||.||.  |||. ||.. ..  ||
pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
0045098 (Phosphotyrosine protein) phosphatases II 134-392 1.6e-76 252.6 In-house 10-273 (278) alignment 
Range on Protein: 134-392
Range on HMM: 10-273/278.0
AEEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVIledsgpsDYINASHIKAQvgkdTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMD
  ||  |.    .. ...| .  |.||||....|||| .||.       ||||||.|.      . ..||.|||||.|..||| |.||..  || |.|  
llefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivmltel

VESGKVKCHRYWPEsanSPLMVYNRIEVRLENYQNLDNFSIRRILMIDN----ETSEVHHVTQMNFATWPDHSVPSTS--LPLLRFACHMRRIHD-----
|| |..||..||||   .  ..|....|.|.....||.. .|..|...     |. | ..||.... .||||.|||..   ..|..   .|. ..     
velgrekcaqywpe...ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------DRLPIVVHCSAGIGRTGTLITIDAILGLIdrDEEFKVLNIVKGLRKQRQG-MIQTKDQYIFCYKAALEALK
         .  |..||||||.||||||. .. .| |.  .. . .|..|| ||.|| | ..|...||.|.|...|| |.
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPRG_pd Subfamily PTPRG 134-393 6.5e-67 221.0 In-house 22-289 (563) alignment 
Range on Protein: 134-393
Range on HMM: 22-289/563.0
AEEFKTLRQVKAID--NCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSG----PSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWEQRADVI
.|||. | .  . .  ..| ..| .|| |||  |...||..|| |..        |||||..|.    . . ..|| ||||..|..||| |.|||.. .|
seefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy..qkskafiatqgplkdtfddFWrmiWeqnvaii

AMVTMDVESGKVKCHRYWPEsaNSPlMVYNRIEVRLENYQNLDNFSIRRILMID---NET---SEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIH
 |.|  ||.|. ||..|||.  . . . |. ..|.|.. . |   ..|.. . .   ...    ....|.| ....||||.||. ||| | |. .  . .
vmitnlvergrrkcdvYWPk..des.etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

DD-RLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKT
 .   |||||||||.|||||.| .|..|  | ...   |....| .| ||. ..||..|||| ..| |||...
kaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPN23_pd Subfamily PTPN23 134-395 2.5e-66 218.4 In-house 18-284 (288) alignment 
Range on Protein: 134-395
Range on HMM: 18-284/288.0
AEEFKTLRQVKAIDNCEEAK--KAQNKDKNRFRNVLPYDKTRVILEdSGPSDYINASHIKAqVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVT
 ..|| |.| .. .. . .      . .|||.|..||||..|| |. ..  ||||||..|  .   . ..|| |.||..| .||||||.||.. || |..
dkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.gskDDYinAsfvkd.lspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmll

MDVESGKVKCHRYWPESANSPlMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIH-----DDRLP
   | || |..|||||. . . .... ..| |.. ....... | . .  .....|..|. ... .||.. ||..   ||.|   ..  .       . |
skeelgkpkvdrYwPedkget.vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktP

IVVHCSAGIGRTGTLITID-AILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKTVL
.|||||||.||||..  .  |.  |  ..    ....|. ||.||. |.|.|.|. |.|.| ||| . ||
lvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 134-392 1.2e-64 213.2 In-house 22-278 (315) alignment 
Range on Protein: 134-392
Range on HMM: 22-278/315.0
AEEFKTLRQVKaIDNCEEAKKAQNKDKNRFRNVLPYDKTRVIL---EDSGPSDYINASHIKAQvGKDtYEYIACQGPLPNTTQDFWLMVWEQRADVIAMV
.|||. | . . | .   |.. .|  |||..|.||.|..||.|   .||  |||||||.||.   .|   ||| ||||. . .||| ||.....  |.||
seefhdlpdPd.iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksv.ddd.kayiasqgPlkasvddfwrmvlqekvttivmv

TMDVESGKVKCHRYWPESaNSPLMVYNRIEVRLENYQNLDNFSIRRILMidNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDD-RLPIVV
|   |. |.|| .|||.  .. .. .  |.| | . .   .  .|.. .   .. | . ||| .|  |||. |.  .  ||..   ..  ..    ...|
tkkqegdkikcrqywPdr.kadsvefGsikvellsleadtdgvarklvt..rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllv

HCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
|||||.|||| .|.|| ..  | | .   |.|.|| ||..|  ..||...| | | | || |.
hcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 134-391 5.7e-50 164.8 In-house 23-236 (392) alignment 
Range on Protein: 134-391
Range on HMM: 23-236/392.0
AEEFKTLRQVKaIDNCEEAKKAQNKDKNRFRNVLPYDKTRVIL---EDSGPSDYINASHIKAQVGKDTyeYIACQGPLPNTTQDFWLMVWEQRADVIAMV
.|||. | . . | .   |.|  |. |||..|.||||..||.|   .|.  |||.|||.|..   . .  |||.||| . . .||| ||.....  ||||
feefhdlpgpd.iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdneka..yiasqgpnaaslddfwrmvfqenvttiamv

TMDVESGkvkchrywpesansplmvynrievrlenyqnldnfsirrilmidnETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDDRL-PIVV
|   |                                                  ... |.|  |. |||. ||  .  ||.|   ..  . .   |...
tklkegd.............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythplii

HCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
|||||.|||| .|.||...    .     |.|.|  .|..|  |.|||.|| | | | || |
hcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 134-389 3.5e-39 129.4 In-house 9-257 (267) alignment 
Range on Protein: 134-389
Range on HMM: 9-257/267.0
AEEFKTLRQVKAIDN-CEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGpSDYINASHIKAQVGKDtyEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTM
 .||. ....  . . .      .|...||. ..||||.||||| ..   .|||||....   |    .|. |.|| ||  ||. .. .|.  || ..|.
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke.eeyinasyvegyktkn..afivtqdplkntitdfltvihdqkvpvivlltk

dVESGKVkcHRYWPES-ANSPLMVYNRIEVRLENYQNlDNFSIRRILMIDNETseVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDDRLPIVVHC
 |  ...  ...||   ...       .|  ||. .| |   |   | . ||.   | ||   .  |   .     |  |       .. .   |.||.|
.vftdni..rlfwPPkmgqakkyqdltvehslekeen.dyqiitlelkfknes..ahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvac

SAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
|.|.||.||...||. |  . ...  .. . .. .|.|| |...||..||....   |
sdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 134-392 1.1e-28 94.9 In-house 22-277 (312) alignment 
Range on Protein: 134-392
Range on HMM: 22-277/312.0
AEEFKTLRQVKAIDNCEEAkkAQNKDKNRFRNVLPYDKTRVILEDSgPSDYINASHIKAQVgkDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMD
. |.|.. .. .  .|      . || ||. |.  .|. |  |       || |  .|         ....|||| ||.  || ..    .  | ...  
tkeykavgnivsdsectaf..lkfkdlnrypniqcwdrgrftlagd.enfyihanfvkict..kperfvctqgplentcthfwqlalslgstsiillcgf

VESGKVKCHRYWPESANS----PLMVYNRIEVRLENY-QNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHmrrIHDDRLPIV
|| |  || .|  .           ||      .|   .  |. . | . .. . | .  .. . ..|.|||| .| .    ||.      .. |. |..
vedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsa...vkkdkkpvi

VHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
 |||||.||||||. |....  .      .| ..   |||.|   ...  ||... .. || | 
ahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
0046845 (Phosphotyrosine protein) phosphatases II 135-394 1.6e-86 285.5 In-house 4-277 (284) alignment 
Range on Protein: 135-394
Range on HMM: 4-277/284.0
EEFKTLRQVKAID--NCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGP----SDYINASHIKAQVG---KDTYEYIACQGPLPNTTQDFWLMVWEQRAD
|||..|....     ... |.. .|..|||....||||..||.|   ..    |||||||...       . . ..||.|||||||. ||| |||||.. 
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

VIAMVTMDVESGKVKCHRYWPESanSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNE-TSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDD-
|| |.|  || |..||..|||..  .  ..|... |.| .... |.. .|.. . ... |.|...||.. . .||||.||... .||.|   .|..... 
vIVmltelvengrekcaqYwple..gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

--RLPIVVHCSAGIGRTGTLITIDAILGLIDRDE---EFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKTV
    |||||||||.|||||.|..| .| ......   .. ||..|| ||.|| ||.|| .||.|.|.|.||.||..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
DSPc_SM00195 135-391 7.2e-86 283.1 In-house 4-262 (263) alignment 
Range on Protein: 135-391
Range on HMM: 4-262/263.0
EEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDS---GPSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVT
|||..|.. .  ....||.| .||.|||..|.||||.|||.|...    .||||||..|| .  . . .|||.|||||.| .||| ||||..  .|.|.|
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

MDVESGKVKCHRYWPESAnSPLMVYNRIEVRLENYQNLD-NFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDD-RLPIVV
...|.|| ||.|||||..    .....|.| | .... . .. .| . .  ....| . |||... .||||.||..  ..|..   ..  ..    ||||
eeeengkekcdrywpees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
|||||.|||||..||| ||  ......... .||| ||||| ||.||..||.|.|.|.||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 135-391 7.2e-86 283.1 In-house 4-262 (263) alignment 
Range on Protein: 135-391
Range on HMM: 4-262/263.0
EEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDS---GPSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVT
|||..|.. .  ....||.| .||.|||..|.||||.|||.|...    .||||||..|| .  . . .|||.|||||.| .||| ||||..  .|.|.|
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

MDVESGKVKCHRYWPESAnSPLMVYNRIEVRLENYQNLD-NFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDD-RLPIVV
...|.|| ||.|||||..    .....|.| | .... . .. .| . .  ....| . |||... .||||.||..  ..|..   ..  ..    ||||
eeeengkekcdrywpees.ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
|||||.|||||..||| ||  ......... .||| ||||| ||.||..||.|.|.|.||..
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 135-389 1.4e-64 213.4 In-house 38-289 (319) alignment 
Range on Protein: 135-389
Range on HMM: 38-289/319.0
EEFKTLRQVK-AIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDS---GPSDYINASHIKAQVGKDTyeYIACQGPLPNTTQDFWLMVWEQRADVIAMV
 ||. . ..     . . |   |||||||. |.|..||..| ||       |||||||...    ||   |||.||||.|| .||| |.||...  | ..
vefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdk..yiaaqGPldntladfWrmiweyncstivll

TmdvesgKVKCHRYWPESANsplMVYNRIEVRLENYQNLDNFSIRRILMID-NETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACH---MRRIHDDRLP
|      | || .|||  ..   . ..| .|...  .. ... .| | . .  .  .. ..||  |  |||. ||  . .|.|.  .   ...  ..| .
t......kdkcsqywplkiv...ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhran

IVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
||||||||.||||. |..|..|  .....   | |.|..||.||. ..|   || |.| | ||
ivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 135-392 6.6e-64 210.8 In-house 22-277 (515) alignment 
Range on Protein: 135-392
Range on HMM: 22-277/515.0
EEFKTLRQVkAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVIL---EDSGPSDYINASHIKAQVGKDtyEYIACQGPLPNTTQDFWLMVWEQRADVIAMVT
|||. |     |     |..  |  |||..|.||||..||.|   .|.  |||.|||.|..        ||| |||.. ...||| .|....   |||||
eefhdlpgp.niypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndk..ayiasqgPnkasvddfWrlvlqenvttiamvt

MDVESGKVKCHRYWPE-SANSplMVYNRIEVRLENYQNLDNFSIRRILMIDNETseVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDD-RLPIVV
   |. |.|| .|||.  ..|  . .  |.| |   .   .  .|.. .. ..   .. ||| .|  |||. ||  .  ||..   ..  |.    |...
klkegdkikcgkyWPdkpgds..vkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythplii

HCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
|||||.|||| .|.|| ..  .   .   |.|.|. .|..|  ..||..|| | | | || |.
hcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 135-315 2.2e-35 116.9 In-house 11-191 (297) alignment 
Range on Protein: 135-315
Range on HMM: 11-191/297.0
EEFKTLRQVKAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGP-SDYINASHIKAQVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMD
.|  .| . .  ..   ||.     |||.|..| .|.||| |  . . .||||| ..     .  . ||  |||| .| .||| .|.||   ||.||.  
aekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvakl

VESGKVKCHRYWPESANSPLMVYNRIEVRLENY-QNLDNFSIRRILMIDNetSEVHHVTQMNFATWPDHSVPSTSLPLLRFAC
 | |. ||  |||.. .  |   . .   | .. .. |.  .  . .|    ||  .|. ..| .|||| |||    | || .
qedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_CG7180_pd Subfamily CG7180 136-390 1e-49 163.8 In-house 22-289 (296) alignment 
Range on Protein: 136-390
Range on HMM: 22-289/296.0
EFKTLRQVkAIDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDS---GPSDYINASHIKAQVGKDtyEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTM
|.|.  ..  |..|  . ...|..|||  .|.|||..||.||       ||||||... . . |   |||  ..|  .| ..|| .|... .. . ..| 
elkltprl.eigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkk..eyivteapkketvdefWrlvydeeisavvvLtk

DVESGKvKCHRYWPESAnspLMVYNRIEVRLENYQNLDNFSIRRILMIDN----------ETSEVHHVTQMNFATWPD-HSVPSTSLPLLRF---A-CHM
  .  | ... |||. .      |  |.| . ..... |. || . .  .          .. |.  |..... .|.  ..||. .  |. .   .   .
tfdfak.mypsywpnks...keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

RRI--HDDRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEA
...  .... |.||..| | .|.|  ..||| | |....||. | . || ||..|.........| ..|   |||
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_hpo-7_pd Subfamily hpo-7 136-387 3e-15 50.9 In-house 10-223 (263) alignment 
Range on Protein: 136-387
Range on HMM: 10-223/263.0
EFKTL-RQVKAIDNCeeakkaqnkdknrfrnvlpydktrviledsgpsdyinASHIKAQVGKDTYE---YiacqgpLPNTTQDFWLMVWEQRADVIAMVT
.|..| | .   | |                                     . |.| .  |.  .          | .| . |. ..  ....|..|..
kfgklPrilidedvc.....................................tehfkPekdkkrknlysl......lvqtidkfyqtivqtktevvvmLc

MDVESGKVKCHRYWPESANSPLMVyNRIEVRLENYQNlD-NFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLrfacHMRRIHDDRLPIVVH
   | |..|| .|.|   .  ... . ..|   . |. |     . .| . .|  ..| |..  .  |...  |  .   |    .. ..  .  ..|||
DfneegvekcssyfPlekdekqkl.anvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelareil....nilkvarnskslvvh

CSAGIGRTGTLITIDAILG----LIDRDE--EFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAA
||.||||.     .. .       .|  .  |.  |.... ||..|.. |.|  |  |     
cstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 139-390 5.7e-46 151.7 In-house 14-265 (283) alignment 
Range on Protein: 139-390
Range on HMM: 14-265/283.0
TLRQVKAIDN-CEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGPsDYINASHIK-AQVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVES
.|...   |  .. |   .|| |||.....|.|. || |.   . |||||..|  ..  |.  .||..|.|| .| .||| ||.....  | |.|   | 
vlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqed

GKVKCHRYWPESANsplMVYNRIEVRLENYQNLDNFSIRRILMIDN-ETSEVHHVTQMNFATWPDHSVPSTSLPLLRFAC-HMRRIHDDRLPIVVHCSAG
 ..|| .|||.      . |    | |..    . |.|. .|.  |  . .   ..   .  | . .  .    |..|      . .  . |||||||.|
lrikCsqyWPkrGs...edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstg

IGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEA
||||...|.. | .  .  .    | ..|| .|.|| ...||.||| . ....|| 
iGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 140-388 8.8e-17 56.0 In-house 11-218 (255) alignment 
Range on Protein: 140-388
Range on HMM: 11-218/255.0
L-RQVKAIDNCEEAKKAQNKDKNRFRNVLpydktrviledsgpsdyinashikaqvgkdtyeyiacqgplpnTTQDFWLMVWEQRADVIAMVTMDVESGK
| | .   | | |  | ... |..  ..|                                           | . |. ..  ....|..|..   | |.
lPrilidedvctehvkPekdkkrknlysl...........................................tvdkfyqtivqtktevvvmlcdfaeegv

VKCHRYWPESANSPLMVyNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFachmRRIHDDRLPIVVHCSAGIGRT
.||..|.|   .  |.. . ..|   .  .   .  ..|.    |  . | |.  ..  |...  |  .  .|       ..  |  ..|||||.||||.
ekcssyfplekdeklkl.advnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilni....lkvvrdsksvvvhCstGiGrs

GTLITIDAILG----LIDRDE--EFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAAL
 ... .. .       .|. |  |.  |.... ||..|.. |.|  |  |.    |
aafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 144-381 2.8e-36 119.8 In-house 35-271 (301) alignment 
Range on Protein: 144-381
Range on HMM: 35-271/301.0
KAID--NCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGPSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKC
 .||  . .|.    .|||.|. .|    .| | . . |    | |  |...   ..  .|| ||||.||..||| |.     . |.|..  ||  . ||
ttidkdhitesyaylpkdkhryptvPckPstavevivdGkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekc

HRYWPESANSPLMVyNRIEVRLENYQNL-DNFSIRRILMIDNETSEVH--HVTQMNFATWPDHSVPSTSLPLLRFachMRRIHDDRLPIVVHCSAGIGRT
. | | . .. | . .| .....| . . ..  ..| | . . | ...   ||  ....|.|. || .   |  .   |  . . . ||||||||||||.
eeylpvkisekldi.grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdl...melvkksekPivvhcsaGiGrs

GTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYI
 ..|. . .   .. | . .. . .| ||..|   .||. |  
vafigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_eak_pd Subfamily eak 146-305 3.7e-16 53.4 In-house 41-196 (332) alignment 
Range on Protein: 146-305
Range on HMM: 41-196/332.0
IDNCEEAKKAQNKDKNrFRNVLPYDKTRVILEDS--GPSDYINASHIK-AQVGKdtyEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCH
.   .|... .. ..|   ...|||.  | |  |   .  ||||| .. ..||.   .||    .  .    || || ||..  | ..  ||| .  |  
llsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGr...kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksd

RYWPESANSpLMVYNRIEVRLENYQNLDNFSIRRI-LMIDNETSEVHHVTqmnFATWPDHSVPS
.|.|. .    . .  ..|   .. . ...  | . |   ||| .|.| .   .  | . ..| 
kyfpdktre.elkfGildverkefvkrniletrllelskGnethrvlhyk...vfGwtettlpk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 146-265 6.2e-15 49.4 In-house 37-167 (349) alignment 
Range on Protein: 146-265
Range on HMM: 37-167/349.0
IDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDS-----------------GPSDYINASHIKAQVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIA
||. . ..  .   |||....|||. .||.|. |                  . ||||| ..|    .    ||| | ||| | .||. ..  ..  .. 
iddvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvl

MVTMDVESGKVKCHRYWPESAnsplmvYNRIEVRLEN
 .. | | .  ||..|| | .      |. |.|.| |
sLnddkelslekcdiywqels......ysnitvklqn
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 146-192 9.1e-08 25.8 In-house 36-85 (440) alignment 
Range on Protein: 146-192
Range on HMM: 36-85/440.0
IDNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDS---GPSDYINASHIKA
 . .. |   .|| |||.||.| ||..||.||.      |||||||.|..
sqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
0040439 (Phosphotyrosine protein) phosphatases II 147-391 3.3e-74 244.9 In-house 1-246 (249) alignment 
Range on Protein: 147-391
Range on HMM: 1-246/249.0
DNCEEAKKAQNKDKNRFRNVLPYDKTRVILED---SGPSDYINASHIkaQVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHR
.....|..  ||||||....|||| .||.|..     .|||||||.|   . . . ..||.|||||.|. ||| |.||..  || |.| .|| |..||..
geysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi..dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaq

YWPEsanSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHD---DRLPIVVHCSAGIGRTGT
|||.   .  ..|... |.| ... .|.. .| . . .....|...|.....  ||||.||..  .||.|   .| ...   .  |..||||||.|||||
ywpl...ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

LITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
.|... .| ....  .. ....|| ||.|| |..|. .||.|.|.|.|| |
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPRK_pd Subfamily PTPRK 147-390 5.3e-65 214.3 In-house 33-276 (314) alignment 
Range on Protein: 147-390
Range on HMM: 33-276/314.0
DNCEEAKKAQNKDKNRFRNVLPYDKTRVILE---DSGPSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHR
.  . ||| .|..|||. ..|.||..||.|    .   ||||||. | .   | . ..|. ||||..|..||| .|.....  | |.|  || |.||| .
egwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsy..krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClk

YWPESANSplmvYNRIEVRLENYQNLDNFsIRRILMIDN---ETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHD-DRLPIVVHCSAGIGRTG
|||| ..     |. |.| | . . | .. . ||. . .     .|.. | |..| .|||| ||     ||..  ..   .. .  .|||||||| ||||
yWPedtev....ygdikvelvetellael.vvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtG

TLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEA
| |.|| .| .|.|..   | |.|| ||...  |..|..||.|.| ..|||
tfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 147-389 4.7e-38 125.8 In-house 25-268 (285) alignment 
Range on Protein: 147-389
Range on HMM: 25-268/285.0
DNCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSgPSDYINASHIKAqVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWP
 ||  .    | | ||. .|   ..|||.|..    ||| || ..   |||   ||. |||||.|  ||| |.....   . |.   .| |  ||  |.|
pnctytayeanpdlnryadvrcieetrvvlknh.drdyihaswmrm.pgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp

ESANSpLMVYNRIEVRLENYQNL-DNFSIRRILM---IDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDDRLPIVVHCSAGIGRTGTLI
|     .. . . |. | . ..     .|   |     .. .||  .. ...   |||.  |  . |.. .   ....     ||.||||||.||| |..
eklge.vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfv

TIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
 ||     |  . . ..|.||. .|  |   .|.. |..| |   .|
gidyatirimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 147-273 8.5e-26 85.5 In-house 37-176 (350) alignment 
Range on Protein: 147-273
Range on HMM: 37-176/350.0
DNCEEAKKAQNKDKNRFRNVLPYDKTRVILE-----------DSGPSDYINASHIKAQ----VGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVT
.. . ..  .   |||..|.|||...||.|.              ..|||||...| .      .  . ||| |.|||.| .||. .. .    || ..|
nDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslt

MDVESGKVKCHRYWPESANSPLMVynRIEVRLENYQNLDNFS
 ||| .  ||.|||.| . .   |  ... . ||  . .. |
sdvelnlekcyrYWqegsydditv..klaskwenimgindss
subfamily_PTPN1_pd Subfamily PTPN1 148-394 2.3e-67 221.8 In-house 23-274 (290) alignment 
Range on Protein: 148-394
Range on HMM: 23-274/290.0
NCEEAKKAQNKDKNRFRNVLPYDKTRVILEDSgPSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPE
...|||. .|...||.|.| |||..|..||..   |||||| ....  .   .||  |||||||.. ||.|||||..  . |.   || ...||..|||.
ptreaklpenrnlnryrdvspydhsriklera.dndyinaslvele..eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

SANSPLMVYN--RIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRR---IHDDRLPIVVHCSAGIGRTGTLI
  ..  ....  ...|.| . .. ... .| . . . .| | ...... . |||| .||..   .|.|  ..|.   . .|  | |.||||||||.||..
geeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc

TIDAILGLIDRDEEFKVLNIVK---GLRKQRQGMIQTKDQYIFCYKAALEALKTV
 .|..| ||.. .. . ..| |    |||.| |.|||.||  | | | ||  |..
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 148-391 1.9e-61 202.8 In-house 40-279 (315) alignment 
Range on Protein: 148-391
Range on HMM: 40-279/315.0
NCEEAKKAQNKDKNRFRNVLPYDKTRVIL---EDSGPSDYINASHIKAQVGKDTyeYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRY
  . ||| .||.|||. |...|||.|| |   |    |||.||. |.    |.   |||.|||.... .||| .|.|.    | |.|  ||  | |. .|
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrr..yiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaeky

WPESanspLMVYNRIEVRLENYQNLDNFSIRRILMIdnETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDDR-LPIVVHCSAGIGRTGTLIT
||.      ..| .| | . . .  .....| . ..    .....| |.....|||  ||  ..||. .  .... |..   .||||||||.|||||.||
wpdk....kviyGkitvtrkseevnteytvrtlsvv..fgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfit

IDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
.||.|  .. ..   | |...|.|..|..|.|. .|| | |.| ||..
ldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 148-225 2.5e-11 37.7 In-house 28-111 (347) alignment 
Range on Protein: 148-225
Range on HMM: 28-111/347.0
NCEEAKKAQNKDKNRFRNVLPYDKTRVILED----SG----PSDYINASHIKAQVGkdTYEYIACQGPLPNTTQDFWLMVWEQRAD
..  ..  .. .||| ..|   |.|||.|       .    .  |||||||| .    . |||  | |||.| .||| ||   .  
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdna..skeyiltqyplpdtvrdfwkmvsvtkvt
0042113 (Phosphotyrosine protein) phosphatases II 149-391 6e-73 240.6 In-house 1-243 (245) alignment 
Range on Protein: 149-391
Range on HMM: 1-243/245.0
CEEAKKAQNKDKNRFRNVLPYDKTRVILEDSGP---SDYINASHIkaQVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYW
.. |..  ||||||....|||| |||.| . |.   |||||||..   . . |  .||.|||||.|..||| |.||..  .| |.| ..| |.|||..||
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

PEsanSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHD--DRLPIVVHCSAGIGRTGTLIT
|.   .  ..|... |.| ....||.. .| . . .. ..|...|... .  ||||.||...  ||.|   .|..    .  |..||||||.|||||.|.
pl...gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfia

IDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
.. .| ....  .. . ..|| ||.|| |..|| .||.|.|.|.|| |
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 149-389 9.2e-69 227.0 In-house 2-240 (243) alignment 
Range on Protein: 149-389
Range on HMM: 2-240/243.0
CEEAKKAQNKDKNRFRNVLPYDKTRVILEDsgpSDYINASHIKAQvgkDtyEYIACQGPLPNTTQD----FWLMVWEQRADVIAMVTMDVESGKVKCHRY
.  |.. .|..|||....|||| .||.||.   ||||||..|.     .   .||.|||||.|..|    || |.||.. .|| |.| .|| |..||..|
fsiallpenlsknrysdilpydhsrvkleg...sdyinanliyvt...p..rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPesaNSPlmVYNRIEVRLENYQNLDNFSIRRILMIDNE-TSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRI---------HDDRLPIVVHCSAG
||   ..   .|....|.| ....||.. .| .|.   . . ....|..  .  ||||.||..  .||.|  ..| .          |.  |..||||||
wp...gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

IGRTGTLITIDAILGLIdrdeEFKVLNIVKGLRKQRQG-MIQTKDQYIFCYKAALE
.|||||||... .| |.    .. ....|| ||.|| | ..|| .||.|.|.|.||
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_egg_pd Subfamily egg 149-389 2e-27 90.7 In-house 32-268 (307) alignment 
Range on Protein: 149-389
Range on HMM: 32-268/307.0
CEEAKKAQNKDKNRFRNVLPYDKTRVILEDS-G--PSDYINASHIKAQVgkDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESgkVKCHRYW
 ..| .. |..| | . |   | .|| ||   |    |.| | ..| .      |.| .| || || .||| ||.... . | |.|  .||   .|. ||
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkp..llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyyw

PESANSPLMV---YNRIEVrLENYQNLDN-FSIRRILMIDNETSEVhHVTQMNFaTWPDHSVPSTSLPLlrfachMRRIHDDRLPIVVHCSAGIGRTGTL
| . . .|..     |||  |. ... |  | . .. ..  .  |  ..   .   .   |   . | .      .|.. .   |.||..  |. ...||
pkaesdslvtvpGslrien.lkvdskadplfrvtklklvGgddeer.flehwqg.dvnnssdvysplrv......lrklrnlskpvvvqdilGvskaatl

ITIDA-ILGLIDR-DEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
..|.  .| |.      . ||. |. ||..|.  ...  .|.| |.  | 
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 150-394 1.4e-63 209.6 In-house 21-271 (274) alignment 
Range on Protein: 150-394
Range on HMM: 21-271/274.0
EEAKKAQNKDKNRFRNVLPYDKTRVILED----SGPSDYINASHIKAQVGKDTyEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYW
|| . . .. |||....|| ...||.||     .  |.|||| .||   ....  |.| ||||||| .|||.|.......|| |.|   |. . ||..|.
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeesk.ayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyf

PESANSP-LMVYNRIEVRLENYQNLDNFSIRRILMIDNETseVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDDR----LPIVVHCSAGIGRTGT
|.. .      |. .|.. |.  . ...|.|....   |    ..|. . .. |||| .|    .||..  .... ....     |.|||||||||||| 
Pdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGc

LITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKTV
 |.|.  .  .....   ||.||  || .| ||.||..|| . ..|  . || .
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 150-392 3e-62 205.1 In-house 13-265 (270) alignment 
Range on Protein: 150-392
Range on HMM: 13-265/270.0
EEAKKAQNKDKNRFRNVLPYDKTRVILEDS---GPSDYINASHIKAQVGKDTYeYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWP
.  . |..|  ||....||  .|||.||.      . |||| ...   |.... ||| .||||.|...|| |.||...  |.|.|  .| |. || ||||
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkk.YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWp

ESANSPL-MVYNRIEVRLENyQNLDNFSIRRILMIDnETSEVHHVTQMNFATWPDHSVPSTSL------PLLRFACHMRRIHDDR---LPIVVHCSAGIG
..... . . .  |.|. .. .. ....|.. | .  |..| ....   . |||||.||...        ||.   ..|| ...     |..||||||.|
aepkekvkledgkikvlals.eekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
||||||..| .. |......  ||.|.. |||.|  ..|. .|| | ||| .|  .
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 150-392 1.6e-56 186.2 In-house 31-278 (287) alignment 
Range on Protein: 150-392
Range on HMM: 31-278/287.0
EEAKKAQNKDKNRFRNVLPYDKTRVILEDSG--PSDYINASHIKAQvgKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPE
 .|..  .  |||. .|||.|.|||.|   |   |||||| .. .   .|  ..||.|||.. | .||| .|.|.|. .....| .|| .. ||..||||
kaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasy..tddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPe

SaNSPLMVYnRIEVRLENYQNL-DNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHM------RRIHDDRLPIVVHCSAGIGRTGT
  . |..|     | | .|...  ....| . .|| || | . | |... .|||.... |.. |.||.  .      .|  ..  |.|||...||||.|.
r.evPmrvG.GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGi

LITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
|... ...       .  | ..|  ||..|....|.  |. . |.|     |
llatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 150-389 1.9e-52 172.8 In-house 1-239 (239) alignment 
Range on Protein: 150-389
Range on HMM: 1-239/239.0
EEAKKAQNKDKNRFRNVLPYDKTRVILED---SGPSDYINASHIKAQVGKDtYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWP
| |||  || |||. |.. ||..||.||       |||||||...   |     ||| || .  .. ||| |.|..|  || |.|  .|  | |||.|||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp.kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp

ESANSplmvYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFAchmRRIHDDRL----PIVVHCSAGIGRTGTLI
.|..     |  . | | . . . .. || ..| .   .| ..| |  |. |||. ||  .  .| .    |.|  | |    | |.|||||.||||...
dstsk....ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr...rkitkdslpgarpwvihcsagvgrtgafl

TIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
 |||.|    ...   ..| || .|..|  |.|| .||.| . | ||
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
0049772 (Phosphotyrosine protein) phosphatases II 150-394 1.2e-37 125.7 In-house 39-283 (314) alignment 
Range on Protein: 150-394
Range on HMM: 39-283/314.0
EEAKKAQNKDKNRFRNVLPYDkTRVILeD---SGPSDYINASHIKAQvgkdtYEYIACQGPLPNTTQDF----------WLMV--WEQRADVIAM-----
  |..  |.||||. ..||.| .|||| .      |||||||...         .||.||||..|  ||          | ||  ....  .| |     
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------VTMDVESGkvkchrywpesansplmvynrievRLENYQNLDNFSirrilmidNETSEVHHVTQMN-----FaTWPDHSVPsTSL
                 .   . |                         . . ..|...         .|. . .......     .  .||.|.| .. 
ladelsrLdaAlgKtpllildgng........................neptaadlellk........eelydpelferlgikylri.pvpDgsap.lle

PLLRFACHMRRIhDDRLPIVVHCSAGIGRTGTLITIDAILGLIdrdeEFKVLNIVKGLRKQRQ-----GMIQTKDQYIFCYKAALEALKTV
 ...|  ....  |.  |..|||.||.|||||..... .. |      . .  ... .|..|      |.|.. .||.|...| ||.||..
dfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 151-389 9.5e-64 210.6 In-house 19-253 (284) alignment 
Range on Protein: 151-389
Range on HMM: 19-253/284.0
EAKKAQNKDKNRFRNVLPYDKTRVILEDS---GPSDYINASHIKAQVGKDTyeYIACQGPLPNTTQDFWLMVWEQRADVIAMVTmdvesgKVKCHRYWPE
 |   |||||||. ..|..||..| ||       |||||||.|.    ||   |||.||||.|| .||| |.||...  | ..|      | || .||| 
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdk..yiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

SANsplMVYNRIEVRLENYQNLDNFSIRRILMID-NETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACH---MRRIHDDRLPIVVHCSAGIGRTGTLIT
 ..   . ..| .|...  .. ... .| | . .  .  .. ...|. |  |||. ||  . .|.|.  .   ... ...| .||||||||.||||. |.
kiv...ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

IDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
.|..|  .....   | |.|..||.||. ..|   || |.| | ||
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 152-394 3e-68 224.7 In-house 4-245 (250) alignment 
Range on Protein: 152-394
Range on HMM: 4-245/250.0
AKKAQNKDKNRFRNVLPYDKTRVILEDSG---PSDYINASHIKAQVGKdtYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVkCHRYWP-E
||| |||.|||. .....|..||.|| .     |||||||....  ..    .|| ||||..|..||| ||.|. ...| |.|  .||.|. .|.||| |
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

SANsplmVYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDD--RLPIVVHCSAGIGRTGTLITID
 |.     |  . | | . ..  .. .|.. .  .. ..  .| |..| .||| .|| .    | .  .... ..     |..|.||||.||.|. |.||
kae....kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid

AILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALKTV
|.|  . ...   | ...| |||.| .......||.|.|...|.||..|
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 152-390 1.3e-52 173.4 In-house 2-239 (239) alignment 
Range on Protein: 152-390
Range on HMM: 2-239/239.0
AKKAQNKDKNRFRNVLPYDKTRVILED---SGPSDYINASHIKAQVGKDtYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPES
|||  || |||. |.. ||..||.||       |||||||...   |     ||| || .  .. ||| |.|..|  || |.|  .|  | |||.|||.|
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp.kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

ANSplmvYNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFAchmRRIHDDRL----PIVVHCSAGIGRTGTLITI
..     |  . | | . . . .. || ..| .   .| ..| |  |. |||. ||  .  .| .    |.|  | |    | |.|||||.||||... |
tsk....ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglr...rkitkdslpgarpwvihcsagvgrtgaflvi

DAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEA
||.|    ...   ..| || .|..|  |.|| .||.| . | |||
damlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 153-384 5.8e-21 69.4 In-house 43-272 (303) alignment 
Range on Protein: 153-384
Range on HMM: 43-272/303.0
KKAQNKDKNRFRNVLPYDKTRVILEDSgpsDYINASHIKAQVGKDTyeyIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPEsaNSP
.  .| ||||| .|.  |...| | ||    || ||... .  | .   |  | ||. |. ||| |. ||.  .. ..  | |  |.  .  .|.  |  
qfvknmdknrfvdvicldhskvklsds...syihasyleldsskka...iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr..nqd

LMVYNRIEVRLENYQNLD--NFSIRRILMIDNETSE-VHHVTqmNFATWPDHSVPSTSLP-----LLRFACHMRRIhDDRLPIVVHCSAGIGRTGTLITI
.. ..   .|. ......  .    ..| . | .     ||    . .||  |.|| . |     . .    .|.   |  | |    .| ||.||.  .
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvh..hykawphnsipsdgspkfvkqiwqlqsvlrky.sdstptvymslsgcgragtfalf

DAIlgLIDRDEEFKVLNIVKGLRKQRQGMIQ---TKDQYIFCY
..    .   .|   |..|| | . |.| ..      |. . |
eta..hlslhseqasldlvkclenvrngrlhavqnlsqfsvvy
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 153-235 2.7e-06 21.1 In-house 30-111 (332) alignment 
Range on Protein: 153-235
Range on HMM: 30-111/332.0
KKAQNKDKNRFRNVLPYDKTRVILE-DSGPSDYINASHIKAQVGKDTyeYIACQGPLPNTTQ-DFWLMVWEQRADVIaMVTMDVE
|  .| | ||   .  .|..|| |  . |  |. ||| .     | .  || .| |. . |.  || || |..  .| .|  |..
kflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksa..yifaqapfndhteyvfwrmvserkpsmi.lvfgdid
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 155-388 6.9e-51 167.6 In-house 52-280 (290) alignment 
Range on Protein: 155-388
Range on HMM: 52-280/290.0
AQNK--DKNRFRNVLPYDKTRVILEDSGPSDYINASHIKAQvgkdTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSp
 .|    |||...|   |||||||.| .. ||. | ..|         .|  ||.| .|. |.| || .... .| |.   .| || ||..|.|| .   
dkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGl....kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe.

LMVYNRIEVRLENYQNLDNFSIRRILMIDNET-SEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDdrlPIVVHCSAGIGRTGTLITIDAILGLI
 . .  | |   . .. |.  |...| . .      | .  ..  .|||.||. ..| |||    .|..     |.|||||||||||||...|.. | ..
vltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG...pvvvhcsaGiGrtGtfvaievglqil

DRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAAL
    |...|..|. ||. | . .|   ||.   .. |
ldGkeldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 155-389 8.2e-42 137.9 In-house 53-287 (305) alignment 
Range on Protein: 155-389
Range on HMM: 53-287/305.0
AQNKDKNRFRNVLPYDKTRVILEDSGPSDYINASHIKAQVGKDTyEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSPLM
  .. |||...|   |.. | |..  ||||| | .. . .  .   .|..|||| .| ..|| || ... . | |.   || ||.|| .||| .    | 
diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipek.rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

VYNRIEVR-LENYQNLDNFSIRRILMIDNET--SEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRrihDDRLPIVVHCSAGIGRTGTLITIDAILGLI
. . | |  .   . ..  .  .| ...     ..   | ..... |||  ||   |  | .   .|     ..|||||||||||||||...|. ||  |
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair...gskvpivvhcsagigrtgtivaieyileki

DRDEEFK-VLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
  . .   . ..|| || ||   ||.  ||.| ..  |.
aenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 155-384 8.3e-28 91.8 In-house 50-283 (310) alignment 
Range on Protein: 155-384
Range on HMM: 50-283/310.0
AQNKDKNRFRNVLPYDKTRVIL--EDSGPSDYINASHIKAQVGKDTyeYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSP
 ..  |||. .|.  |..|| |  . |   ||| | ..|..  ..|  .| .||||  |  ||| |....||. | ..   .| |. ||  |||    . 
kkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrst..ficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte

LMVYNRIEVRLENYQ-----NLDNFSIRRILMIDNETSEVH--HVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDdrlPIVVHCSAGIGRTGTLITID
     |.    |  .     ||    .   . .|.. ....   |. ...  |||  ||      .      .  |    | |||||||..|........
tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg...pcvvhcsagkdrlyvvvalk

AILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCY
  .  .|| .. .. ...  |.|.|   |||. ||..  
lkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 156-389 5.1e-56 184.6 In-house 2-237 (237) alignment 
Range on Protein: 156-389
Range on HMM: 2-237/237.0
QNKDKNRFRNVLPYDKTRVILEDSG-PSDYINASHIKAQVGKdTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPEsANSPlM
.|| |||. |.  ||..||.|. .|  ||||||...|   |    .|||.|||| .. .||| |||...  || |.|  .|. ..|||.|||. .. |  
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgt.pkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqp.a

VYNRIEVRLENYQNLDNFSIRRILMIDNET-SEVHHVTQMNFATWPDHSVPSTSLPLLRFACHM--RRIH-DDRLPIVVHCSAGIGRTGTLITIDAILGL
 |  . | |   ... ....| .|.  . |  ||  . | .|..|||. ||  .  ||||  ..  |  |  .  | ..|||||.|||| .. |||.|  
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

IDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
    .   . | |. . ..|  .|||||||.| ... ||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 156-391 1.4e-34 114.5 In-house 42-271 (288) alignment 
Range on Protein: 156-391
Range on HMM: 42-271/288.0
QNKDKNRFRNVLPYDKTRVILEDSgPSDYINAsHIKAqVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSPLMV
.|  ..|..|.   | ||| |.|  |  ||.| .. .  .|     | .| ||  | . .| |. |.  . | |..  .| || |   |.|        .
anptrdryenlprcditrvklsdd.pdfyiaa.nvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

YNRIEVRLENYQNLDNFSIRRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDdrlPIVVHCSAGIGRTGTLITIDAILGLIDRDE
     |  ......|      .| | .|. |   | .. .  |.|..||   |. ||.   .. ..    |||||.|||.||||||| |  .|  .  |.
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk...PivvhssaGvGrtgtlililialeslrldd

EFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
   . .... ||..|   |||. ||.. ..  || |
flgirsllaklreerfkaiqtemqylyvhrcvleel
Y_phosphatase Protein-tyrosine phosphatase 157-389 9.3e-78 256.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 157-389
Range on HMM: 1-235/235.0
NKDKNRFRNVLPYDKTRVIL-EDSGPSDYINASHIKAQVgKdTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSpLMV
||.|||....|||||||| | ...||||||||...|    . . ..||.||||..| .||| |||...  ||.|.| ..|.|..||..||||. .   . 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.slt

YNRIEVRLE-NYQ-NLDNFSIRRILMIDNETS-EVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIH-DDRLPIVVHCSAGIGRTGTLITIDAILGLI
|..|.|.|. . . . ... .| . . ..... | ..|.|. . .||||.||... .||..   ... . ... |.|||||||.|||||....|..|  .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

DRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
...||..||.||| |||||.||.|. .||||.||| ||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 157-389 9.3e-78 256.2 In-house 1-235 (235) alignment 
Range on Protein: 157-389
Range on HMM: 1-235/235.0
NKDKNRFRNVLPYDKTRVIL-EDSGPSDYINASHIKAQVgKdTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSpLMV
||.|||....|||||||| | ...||||||||...|    . . ..||.||||..| .||| |||...  ||.|.| ..|.|..||..||||. .   . 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.slt

YNRIEVRLE-NYQ-NLDNFSIRRILMIDNETS-EVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIH-DDRLPIVVHCSAGIGRTGTLITIDAILGLI
|..|.|.|. . . . ... .| . . ..... | ..|.|. . .||||.||... .||..   ... . ... |.|||||||.|||||....|..|  .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

DRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
...||..||.||| |||||.||.|. .||||.||| ||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 157-391 4.9e-45 148.7 In-house 1-171 (182) alignment 
Range on Protein: 157-391
Range on HMM: 1-171/182.0
NKDKNRFRNVLPYDKTRviledsgPSDYINASHIKAQVGKDTyeYIACQGPLPNTTQDFWLMVWEQRADVIAMVTmdvesgkvkCHRYWPesansplmvy
|.||||....|||| .|       ..|||||. .      ..  .||.||||..|. ||. |..|..  .| ..|         ...|||          
nldknrysdilpydhsr.......dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

nrievrlenyqnldnfsirrilmidneTSEVHHVTQMNFATWPDHSVPStSLPLLRFACHMRRihdDRLPIVVHCSAGIGRTGTLITIDAILGLidrdeE
                           . . ....|  .  ||||.||.    ||.|   ...   .  |..||||||.||||||. .. .. |     .
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

FKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
. . ..|| .|..| ||..| .||.|.. |.|| |
vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 160-385 3.2e-21 70.7 In-house 22-253 (290) alignment 
Range on Protein: 160-385
Range on HMM: 22-253/290.0
KNRFRNVLpYDKTRVILEDSGP---SDYINASHIKAQVGkdtYEYIACQGPLPNT-------TQDFWLMVWEQRADVIAMVTMDVE-S---GKVKCHRYW
..| .. |   .|||.|.. |    .||| |....   |    . |. | |. ..        ..|| |. . ... . |.    | |   ... | .| 
dqRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpng...lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PESANSPLmVYNRIEVRLENYQNLDNFSIrRILMIDNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFachMRRIHDDRLPIVVHCSAGIGRTGTLITID
|||..  |  .. ..|.  .  . |.. . | |..  .  | . ||   .  | . .|. ... ||     .. ..  . |..|||  || |  .| .|.
pesvgeel.kfkgltvkCkskekeddvet.RelvvkfddeeeftvtHsllkgWnklnvqedtktllsl...iqkvkasktpvivHcvdGiSrsAalaaii

AILGLID-RDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYK
    .|    ...|. ...| |||||. .|... .. |   
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvda
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 166-383 6.4e-22 72.4 In-house 68-280 (302) alignment 
Range on Protein: 166-383
Range on HMM: 68-280/302.0
VLPYDKTRVILEdSGPSDYINAShikaqvgkdtyEYIA--CQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSPLMVYN------
|| .|. . |.   || |  .             | ..     |  .|.. .| .. . .  ... ..  ||... ||  |. .  .  |   .      
vlkldeikwima.qGpmdGtekk...........ekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktv

RIEVRLENYQNLDNFSIRRILMIDNETSE--VHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIhddRLPIVVHCSAGIGRTGTLITIDAILGLIDRDE
 ..  ||.. .  .| .  . . .... .   . |  . |..||||  |  . . |    .       .  ..||||||.||||||..|   . |  ...
svktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesy...kknvlvhcsaGvGrtGtlvaikyGiqlcskkk

EFKVLNIVKGLRKQRQGMIQTKDQYIFC
  ..|.||. .|. | | .|...| |. 
vtdllsivlpvrqcryGavqdeqqliyl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 167-301 3.1e-10 34.5 In-house 3-124 (130) alignment 
Range on Protein: 167-301
Range on HMM: 3-124/130.0
LPYDKTRVIledsgPSDYINASHIKaqVGKDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVtMDVESGkvkcHRYWPESanSPLMVY-NRIEVRLEN
|... .|.        .||||| .   .   | ||.  | || .|. ||| |. |.  .|. ..   ||        |||.|   ||  | ..| | | .
lefevsrlq.....gntyinasfvG..llgrtaeylltqhpladtsmdfwkmmleryvnvlvvl.gsveee....deywpds..ePlewyeediivtltd

YQNLDNFSIRRiLMIDNETSEVHH-VTQMNFATWPDH
 .. .|      | |...  | |. .| .. . ||  
rdefknikasn.leiesdlneshqaltmfqisnwpsd
0044763 (Phosphotyrosine protein) phosphatases II 169-388 1.9e-29 98.0 In-house 2-168 (178) alignment 
Range on Protein: 169-388
Range on HMM: 2-168/178.0
YDKTRVILE---DSGPSDYINASHIKaqvgkdTYEYIACQGPlpnttQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANsplmvynrievrlen
.| |||.|.   .   |||||||.|        . |.....|     .|.. ...|.  ..| ..| ..| |..||..||||.|.               
ldrtrvllsnleglersdyinaseil......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

yqnldnfsirrilmidnetsevhhvTQMNFATWPDHSVPSTSLPLLRFACHMRRIH-DDRLPIVVHCSAGIGRTGTLITIDAILGLidrdeEFKVLNIVK
                          |. .  .|||.||. .  .|.|   ..... ..  |..||||||.||.|||. .. .. |      . . ....
.........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

GLRKQRQgMIQTKDQYIFCYKAAL
 .|..|  .... .|. ..|. .|
lvrerRp.ivpnpgqlrqLyefel
0046846 (Phosphotyrosine protein) phosphatases II 176-390 1.8e-39 130.6 In-house 6-172 (176) alignment 
Range on Protein: 176-390
Range on HMM: 6-172/176.0
LEDSGPSDYINASHIKAQVgkdtyeYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPESANSPLmvynrievrlenyqnldnfsir
| . ...|||||. |          .||.|||||.|..||. |..|.. ... ..| .|| |..||..||||  .  .                      
lgldldldyinanlilgsr......piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

rilmidnetsevhhvtQMNFATWPDHSVPSTsLPLLRFACHMRRIHDDRLPIVVHCSAGIGRTGTLITIDailgLIDRDEEFKVLNIVKGLRKQRQ-GMI
                |  .  ||||.||.    ||..   .|.  ..  |..|||||||||||||. ..    |. ..  ..|..... .|.||  |..
................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTKDQYIFCYKAALEA
|| .|| |.|...|. 
qtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 180-385 2.2e-39 130.3 In-house 3-155 (172) alignment 
Range on Protein: 180-385
Range on HMM: 3-155/172.0
GPSDYINASHIKAQVgkDTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTmDVesgkvkchrywpesansplmvynrievrlenyqnldnfsirrilm
..|||||||...  .   . ..||.||||.||. ||| |..|.  ..| ..| .                                              
egsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnlt.el.............................................

IDNETSEVHHVTQMNFATWPDHSVPsTSLPLLRFACHMRR--IHDDRLPIVVHCSAGIGRTGTLITIDAILglidrdEEFKVLNIVKGLRKQRQGMIQTK
  . . ..... |  .  ||||.|| ..  ||.|   ...  . ..  |..||||||.||||||. .. .|      . ......|. .|..| |..|..
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

DQYIFCYK
.||.|.|.
sqyrflyy
0051429 (Phosphotyrosine protein) phosphatases II 182-394 8.3e-47 155.4 In-house 4-228 (272) alignment 
Range on Protein: 182-394
Range on HMM: 4-228/272.0
SDYINASHIKAQVGKDTYE-YIACQGPLPNTTQDFWLMvWEQRADVIAMVTMDVESGKVKCHRYWP---------ESANSPLMVYNRIEVRLENYQNLDN
|.||||....   ..     .....||||.| .||| . .|.. ..| ... ..| |..||.||||         ..   | . |... |.|  ...|..
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FSIRRILMIDN-ETSEVHHVTQMNFATWPDHSVPSTSlpLLRFACHMRRihddRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFK--------VLNI
. .|..|..    ..|...|... .  ||||.||. .  ||..  ....      |..||||||..||||.. .. .|  ....  ..        ....
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VKGLRKQRQGMIQTKDQYIFCYKAALEALKTV
|. ||.|| |..|| .||.|.|.|.||.|...
veelraqrpgavqteeqylflyeallellrsl
0036282 (Phosphotyrosine protein) phosphatases II 182-385 6.3e-42 138.6 In-house 2-164 (174) alignment 
Range on Protein: 182-385
Range on HMM: 2-164/174.0
SDYINASHIKAQVGKDtyEYIACQGPLPnttqdFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPEsansplmvynrievrlenyqnldnfsirrilmid
|||||||...  .  .  ..||.||||.     || |..|..  .. |..  .| |..||..||||                                  
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................

NETSEVHHVTQMNFATWPDHSVPSTSLpLLRFACHMRRIHDD--RLPIVVHCSAGIGRTGTLITIDAILGLIDrDEEFKVLNIVKGLRKQRQGMIQTKDQ
. ....... |  .  ||||.||..|  ||.| . ..... .    |..||||||.||||||. .. .| ..      ..|..|. ||.|| ||.|| .|
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YIFCYK
|.|.|.
yrflyy
0051082 (Phosphotyrosine protein) phosphatases II 182-387 2.7e-30 100.3 In-house 3-149 (151) alignment 
Range on Protein: 182-387
Range on HMM: 3-149/151.0
SDYINASHIKAQvgkdtyeYIACQGPLPnttqDFWLMVWEQRADVIAMVTMDVESGkvKCHRYWPESAnsplmvynrievrlenyqnldnfsirrilmid
|||||.| .          .....|||.    ||. ...|.  ..| ... ..| |  .|..|.||                                  
sdyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

netsevHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRihDDRLPIVVHCSAGIGRTGTLITIDAILglIDrdeeFKVLNIVKGLRKQRQGMIQTKDQYI
      ..|... .  |||...| .   .|.|  ....  ..  |..||||||.||||||. .. .|   .    . .  ... .|..| |..|...|..
......ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvqpnqqfl

FCYKAA
|...| 
fqlfal
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 183-301 5.6e-11 36.5 In-house 123-233 (244) alignment 
Range on Protein: 183-301
Range on HMM: 123-233/244.0
DYINASHIKAqVGKdTYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVtMDVESGkvkcHRYWPESanSPLMVYN-RIEVRLENYQNLDNFSIRRiLMID
 ||||| .   .|. | |||  | || .|. ||| |. |.  .|. ..   ||        |||.|   ||  |.  | | | . ... |      | |.
tyinasfvgc.lgr.taeyiltqhpladtsmdfwkmmlerhvnvlvvl.gsveee....deywpds..eplewyeeditvtltdrdefknikasn.leie

NETSEVHHV-TQMNFATWPDH
 .  | |   | .. . ||  
sdmneshqaltmfqisnwpsd
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 198-385 5.5e-20 66.4 In-house 4-198 (199) alignment 
Range on Protein: 198-385
Range on HMM: 4-198/199.0
TYEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPEsANSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSE--VHHVTQMNF
   |||.| || .|  ||| ||||  .  | ||  |    ..    |||  ..|    |  . |  .      ...|  ... .| |.      ... .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpt.tesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

ATWPDHSVPSTSLpLLRFACHMRRIH-----DDRLPIVVHCSAGIGRTGTLITIDaiLGLIDRDEE----FKVLNIVKGLRKQRQGMIQTKDQYIFCYK
..| ... |  .| .. |    | .      .   |..|||| | | || ....|  .|.   .|       .... | ||. | |.| . ..| | |.
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald..igvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0049260 (Phosphotyrosine protein) phosphatases II 199-385 5.4e-38 125.4 In-house 9-144 (152) alignment 
Range on Protein: 199-385
Range on HMM: 9-144/152.0
YEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWpesansplmvynrievrlenyqnldnfsirrilmidnetsevhhvtQMNFATW
.|.||.|||.|||. ||| |..|. ...| |.| ..| ||.||..|.                                              |  .  |
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................qylhlpw

PDHSVPSTSLPLLRFACHMRR-IHDDRLPIVVHCSAGIGRTGTLITIDAILglidrdEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYK
|||.||. |  || .   ... ..|.  |..||||||.||||||. .. .|        ......|. .|..| |......|..|.|.
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 199-385 6e-20 66.3 In-house 4-197 (198) alignment 
Range on Protein: 199-385
Range on HMM: 4-197/198.0
YEYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMDVESGKVKCHRYWPEsANSPLMVYNRIEVRLENYQNLDNFSIRRILMIDNETSE--VHHVTQMNFA
  |||.| || .|  ||| ||||  .  | ||  |    ..    |||  ..|    |  . |  .      ...|  ... .| |.      ... .|.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpt.tesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

TWPDHSVPSTSLpLLRFACHMRRIH-----DDRLPIVVHCSAGIGRTGTLITIDaiLGLIDRDEE----FKVLNIVKGLRKQRQGMIQTKDQYIFCYK
.| ... |  .| .. |    | .      .   |..|||| | | || ....|  .|.   .|       .... | ||. | |.| . ..| | |.
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald..igvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 200-300 4.9e-08 26.7 In-house 237-330 (440) alignment 
Range on Protein: 200-300
Range on HMM: 237-330/440.0
EYIACQGPLPNTTQDFWLMVWEQRADVIAMVTMdveSGKVKCHRYWPESANSplMVYNRIEVRLENYQNLDNFSIRRILMIDNEtsEVHHVTQMNFATWP
 .|| | ||  |  ||| .| . |   | |.          |  |||  . |  . .  . |     .|..   .| . .  .|  ||| . |..  |||
afiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvntrs..vtfgpftvghkgsenmnrvkvrtlelkyke..evheirqfevqtwp

D
 
t
0048076 (Phosphotyrosine protein) phosphatases II 262-388 1e-24 82.2 In-house 18-140 (145) alignment 
Range on Protein: 262-388
Range on HMM: 18-140/145.0
RLENYQNLDNFSIRRILMIDNET-SEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDDRLPIVVHCSAGIGRTGTLITIDAILGlidrdEEFKVL
  .....| .. |...| . .|.  ......|  .  ||||.||. .  ||.|   .......  |..||||||.||||||. .. .|      . . . 
taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsle

NIVKGLRKQRQGMIQTKDQYIFCYKAAL
.... .|.|| |.... .|..|.|.. |
ealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 264-385 3.3e-23 77.4 In-house 20-139 (144) alignment 
Range on Protein: 264-385
Range on HMM: 20-139/144.0
ENYQNLDNFSIRRILMI---DNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDDRLPIVVHCSAGIGRTGTLITIDAILglidrDEEFKVL
.....| .. |. .. .      ... ....|  .  ||||.||. .  ||.|   .......  |..||||||.||||||.... ..      . . . 
ldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsle

NIVKGLRKQRQGMIQTKDQYIFCYK
.... .|..| |.... .|..|...
ealalvrsrrpgavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 276-388 7.7e-19 62.6 In-house 203-341 (350) alignment 
Range on Protein: 276-388
Range on HMM: 203-341/350.0
RILMIDNETSEVHHVTQMNFATWPDH---SVPSTSLPLLR--------FACHMRRIHDDRLPIVVHCSAGIGRTGTLITIDAILG-------LIDRDEEF
 .  |   .|. . | |...  |.|      |   |. |           ..     .   ||.||||||.||||||.|.| .|        | .. .. 
sltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkl

K--------VLNIVKGLRKQRQGMIQTKDQYIFCYKAAL
.        .  ||. |||||  |.|..||.||.|.|.|
dvaaktrDlisiivnelrkqrismvqnldqfifiYeall
0038934 (Phosphotyrosine protein) phosphatases II 281-382 2.9e-09 32.4 In-house 71-168 (194) alignment 
Range on Protein: 281-382
Range on HMM: 71-168/194.0
DNETSEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIH-DDRLPIVVHCSAGIGRTGTLITIDailgLIDRdEEFKVLNIVKGLRKQRQGMIQTKDQ
| |  | . .. ... .  |..|||... |  .    . .. |    ..||| ||.||||||.       || |   ...   .. .|  |.|.|.. |.
dpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaY....Liyr.lgmsaeeAialfrekRpgaipnqdy

YIF
.  
lea
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 285-391 2.1e-18 60.9 In-house 86-194 (440) alignment 
Range on Protein: 285-391
Range on HMM: 86-194/440.0
SEVHHVTQMNFATWPDHSVPSTSLPLLRFACHMRRIHD--DRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIF
 | . . |...  |||..||  . |.|..   .   ..     |..|||||| |||| .|..|.||    | ..  ...... .|..|  |.|| .|| |
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CYKAALEAL
 ..| ||.|
vheavlegl
subfamily_PTPDC1_pd Subfamily PTPDC1 287-384 3.4e-09 31.4 In-house 80-169 (182) alignment 
Range on Protein: 287-384
Range on HMM: 80-169/182.0
VHHVTQMNFAtWPDHSVPSTSLpLLRFACHMRRIHDDRlPIVVHCSAGIGRTGTLITIDAILglidrDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCY
 .... .||. |.|..|.|    .|     .    ..   . ||| || |||| ||.   .       ....  . .| .|..|   |||..|  .. 
eqgiyvynfg.wkDygvasler.iLdivkvvafalqeg.kvavhChaGlGrtGvliacylvy.....akrltaekaiklvrskrpksiqtreqvelvk
subfamily_PTEN_pd Subfamily PTEN 289-344 5.5e-06 21.5 In-house 81-134 (184) alignment 
Range on Protein: 289-344
Range on HMM: 81-134/184.0
HVTQMNFAtwpDHSVPSTSLpLLRFACHMRR--IHDDRLPIVVHCSAGIGRTGTLITI
.|....|    ||  |. .| | ..  ....   .|..  .|||| || ||||.||. 
rvavypfd...Dhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvliva
PTPc_DSPc_SM00012 290-389 3.6e-33 109.3 In-house 2-105 (105) alignment 
Range on Protein: 290-389
Range on HMM: 2-105/105.0
VTQMNFATWPDHSVPSTSLPLLRFACHMRRIHDDRL---PIVVHCSAGIGRTGTLITIDAILGLIDRD-EEFKVLNIVKGLRKQRQGMIQTKDQYIFCYK
|... . .||||.||..| ..|..  .... . ..    |.|||||||.|||||....| .|  ...  .|.....||| |||||.||.||..||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AALE
| ||
alle
PTEN_1 292-342 6.4e-08 27.6 In-house 92-148 (196) alignment 
Range on Protein: 292-342
Range on HMM: 92-148/196.0
QMNFA----TWPDHSVPSTSLpLLRFACHMRRIHD---DRLPIVVHCSAGIGRTGTLI
....      ..|| .|| |  |..... .        ..  ..||| ||.||.||..
ksgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
subfamily_DSP23_pd Subfamily DSP23 298-380 9.3e-06 20.4 In-house 59-135 (148) alignment 
Range on Protein: 298-380
Range on HMM: 59-135/148.0
WPDHSvPSTSLPLLRFACHMRRIHDDRLPIVVHCSAGIGRTGTLITIDAIlglidRDEEFKVLNIVKGLRKQRQGMIQTKDQY
 .|.  | .   . .|   .   ..    . |||  | |||||...   .     . ...   . .  .|..| | ..| .| 
iddyh.ppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylv.....kerklaaaeaiaevrrlrpgsvetveqe
subfamily_PRL_pd Subfamily PRL 319-386 4.6e-06 20.8 In-house 85-147 (151) alignment 
Range on Protein: 319-386
Range on HMM: 85-147/151.0
RIHDDRLPIVVHCSAGIGRTGTLITIdailGLIdrDEEFKVLNIVKGLRKQRQGMIQTKD-QYIFCYKA
  ..    . ||| ||.||.  |...     ||  .. .|  . |. .|..|.| | .|  ...  |||
fkeepkstvavhcvaGlGraPvlval....ali..eaGmkyedavefirekrrgainskqlkflekyka
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 321-392 3.7e-16 53.9 In-house 225-296 (297) alignment 
Range on Protein: 321-392
Range on HMM: 225-296/297.0
HDDRLPIVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
.   ....||||||.||.| ..  |.||  . ..   .|  |.. ||.||  ..|| .|. ..|.|.|. ||
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 322-389 5.6e-13 42.9 In-house 263-342 (349) alignment 
Range on Protein: 322-389
Range on HMM: 263-342/349.0
DDRLPIVVHCSAGIGRTGTLITIDAILG-LIDRDEEFKVL-----------NIVKGLRKQRQGMIQTKDQYIFCYKAALE
|.  ...|||||| ||||.|.|.| .|  |.   .|.  .            ||  |||||  |.|   |.|..|.| |.
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_CG42327_pd Subfamily CG42327 323-389 7.1e-14 46.2 In-house 246-313 (319) alignment 
Range on Protein: 323-389
Range on HMM: 246-313/319.0
DRLPIVVHCSAGIGRTGTLITIDAILGLIDRD-EEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALE
.. |.||||| |.||||..|. |  .  ..   .   . ..|  .|..|   ..||.|| | || . |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_CDC14_pd Subfamily CDC14 324-380 1.1e-06 22.7 In-house 263-314 (328) alignment 
Range on Protein: 324-380
Range on HMM: 263-314/328.0
RLPIVVHCSAGIGRTGTLITIDAIlglidRDEEFKVLNIVKGLRKQRQGMIQTKDQY
.  |.||| ||.|||||||.   .     .. .|   ...  ||  | |.. .. | 
eGaiavhCkaGLGrtGtLiacylm.....khyrftaaeaiawlricrPGsvigpqqk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 327-392 1.4e-12 41.9 In-house 1-66 (69) alignment 
Range on Protein: 327-392
Range on HMM: 1-66/69.0
IVVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
.|||||.| |||||.|.|   .  |  .    ..| |. .|| |  |.  . .||| . |  ||||
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 328-392 5e-12 40.0 In-house 1-65 (69) alignment 
Range on Protein: 328-392
Range on HMM: 1-65/69.0
VVHCSAGIGRTGTLITIDAILGLIDRDEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEALK
|||||.| |||||.|.|   .  |  .    ..| |. .|| |  |.  ...|.| . |  ||||
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
subfamily_ptpA1_pd Subfamily ptpA1 354-391 1.2e-07 25.8 In-house 361-398 (418) alignment 
Range on Protein: 354-391
Range on HMM: 361-398/418.0
DEEFKVLNIVKGLRKQRQGMIQTKDQYIFCYKAALEAL
  .|....||  ||.|| ||.|  .||.||||. |. .
ridfnlfsivlklreqrpgmvqqleqylfcyktildei