Gene PTPN23-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN23
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP060_AA protein Get Run
SpurP060_AA_74-303 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN23_pd Subfamily PTPN23 1-71 6.7e-37 121.8 In-house 56-126 (288) alignment 
Range on Protein: 1-71
Range on HMM: 56-126/288.0
DHNRVCLRGTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKVSNE
|||||.|||..||||||||.||..|..|.|||||||||..|||||||||||..|.|||||||...|| ...
DhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd
0050432 (Phosphotyrosine protein) phosphatases II 1-62 2.4e-20 68.5 In-house 81-142 (308) alignment 
Range on Protein: 1-62
Range on HMM: 81-142/308.0
DHNRVCLrGTRDDYINASFIKDVV-PTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
||.||.| .  .||||||...  .   .  |||||.||. ...||| ||.||. ..|||| . 
dhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtkl
0036941 (Phosphotyrosine protein) phosphatases II 1-61 3.7e-20 67.8 In-house 52-111 (297) alignment 
Range on Protein: 1-61
Range on HMM: 52-111/297.0
DHNRVCLRGTRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
||.||.| .  .||||||.. |.   .  |||||.||. ...||| ||.||. ..|||| .
dhtRVklddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlte
0047943 (Phosphotyrosine protein) phosphatases II 1-62 3.8e-20 67.9 In-house 51-111 (273) alignment 
Range on Protein: 1-62
Range on HMM: 51-111/273.0
DHNRVCLRGTRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
||.||.| .  .||||||.. |. .... |||||.||. ...||| ||.||....|||| . 
dhsrvklgdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtel
0051299 (Phosphotyrosine protein) phosphatases II 1-62 5.7e-20 67.4 In-house 62-126 (288) alignment 
Range on Protein: 1-62
Range on HMM: 62-126/288.0
DHNRVCLRG----TRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
||.||.|.       .||||||.| |. ...  |||||.||. ...||| ||.||. ..|||| . 
dhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltkl
0046845 (Phosphotyrosine protein) phosphatases II 1-62 3.9e-19 64.6 In-house 41-111 (284) alignment 
Range on Protein: 1-62
Range on HMM: 41-111/284.0
DHNRVCLRG-----TRDDYINASFIKDVV----PTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
||.||.|.        .||||||...        ... |||||.||. ...||| ||.||....|||| . 
dhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltel
subfamily_PTPRD_pd Subfamily PTPRD 1-67 8.4e-19 62.6 In-house 61-130 (564) alignment 
Range on Protein: 1-67
Range on HMM: 61-130/564.0
DHNRVCLRGTRD----DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGK
||.||.|. ..     ||||||||.    ..  .||||.||.....||| ||.||. |.|||| .    ||
dhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgk
0040438 (Phosphotyrosine protein) phosphatases II 1-66 1.5e-18 62.6 In-house 56-124 (317) alignment 
Range on Protein: 1-66
Range on HMM: 56-124/317.0
DHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATG
||.||.|  .     .||||||.. |.   .. |||||.||. ...||| ||.||. ..|||| .    |
dhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelg
Y_phosphatase Protein-tyrosine phosphatase 1-63 5e-18 60.8 Pfam-A 14-77 (235) alignment 
Range on Protein: 1-63
Range on HMM: 14-77/235.0
DHNRVCL--RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKP
|..|| |  .... |||||...|    ..  |||||.||. ...||| ||.... ..|||| |  
dktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsle
Y_phosphatase Protein-tyrosine phosphatase 1-63 5e-18 60.8 In-house 14-77 (235) alignment 
Range on Protein: 1-63
Range on HMM: 14-77/235.0
DHNRVCL--RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKP
|..|| |  .... |||||...|    ..  |||||.||. ...||| ||.... ..|||| |  
dktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsle
0043336 (Phosphotyrosine protein) phosphatases II 1-67 9.6e-18 60.1 In-house 58-127 (278) alignment 
Range on Protein: 1-67
Range on HMM: 58-127/278.0
DHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGK
||.||.|  .     .||||||.. |. . .. |||||.||. ...||| ||.|.. ..|||| .    |.
dhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgr
0039614 (Phosphotyrosine protein) phosphatases II 1-66 1.1e-17 60.0 In-house 69-139 (297) alignment 
Range on Protein: 1-66
Range on HMM: 69-139/297.0
DHNRVCLRGTR-----DDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATG
||.||.| . .     .||||||...    ... |||||.||. ...||| ||.||. ..|||| .    |
dhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelg
0045098 (Phosphotyrosine protein) phosphatases II 1-62 2.1e-17 58.9 In-house 46-98 (278) alignment 
Range on Protein: 1-62
Range on HMM: 46-98/278.0
DHNRVClrgtrdDYINASFIKDVvptSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
||.||.      ||||||.|.     .. |||||.||.  ..||| |..|.. ..|||| . 
dhsrVk......dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltel
0045450 (Phosphotyrosine protein) phosphatases II 1-64 2.3e-17 59.2 In-house 68-143 (307) alignment 
Range on Protein: 1-64
Range on HMM: 68-143/307.0
DHNRVCLRG-----TRDDYINASFIKDVV-------PTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPA
||.||.|         .||||||.... .         .  |||||.||. ...||| |..||. ..|||| .   
dhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve
DSPc_SM00195 1-63 5.4e-17 57.4 In-house 39-104 (263) alignment 
Range on Protein: 1-63
Range on HMM: 39-104/263.0
DHNRVCLRGT----RDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKP
||.|| |  .     .|||||..||     .  .||||.||.  ..||| ||.|.. .||||| .  
dhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteee
PTPc_SM00194 1-63 5.4e-17 57.4 In-house 39-104 (263) alignment 
Range on Protein: 1-63
Range on HMM: 39-104/263.0
DHNRVCLRGT----RDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKP
||.|| |  .     .|||||..||     .  .||||.||.  ..||| ||.|.. .||||| .  
dhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteee
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-63 5.2e-16 53.7 In-house 69-134 (298) alignment 
Range on Protein: 1-63
Range on HMM: 69-134/298.0
DHNRVCLRG----TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKP
|. || |.        |||||||..     .. ||||||||.....||| || |.... |||| .  
dssRvvLekedadeesdYiNAsflhayk.grnafiatqaPltetvedFWrmvteedigtiVmltnle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1-60 8.2e-16 52.9 In-house 16-77 (237) alignment 
Range on Protein: 1-60
Range on HMM: 16-77/237.0
DHNRVCLRGT--RDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
||.|| |.|.    |||||...|..  |   .||.| ||..| .||| ||.... |.|||| 
dhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmlt
0040439 (Phosphotyrosine protein) phosphatases II 1-67 8.5e-16 53.8 In-house 24-93 (249) alignment 
Range on Protein: 1-67
Range on HMM: 24-93/249.0
DHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGK
||.||.|  ..    .||||||.| |.   .. |||||.||. ...||| |..|.. ..|||| |    |.
dhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgr
0042113 (Phosphotyrosine protein) phosphatases II 1-66 1.2e-15 53.0 In-house 22-90 (245) alignment 
Range on Protein: 1-66
Range on HMM: 22-90/245.0
DHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATG
||.||.|  .     .||||||.. |.   .| |||||.||. ...||| |..|.. ..|||| .    |
dhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelg
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-68 2.1e-15 51.6 In-house 22-92 (250) alignment 
Range on Protein: 1-68
Range on HMM: 22-92/250.0
DHNRVCLRGTR----DDYINASFIKDVVPTsPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKV
|. || |  ..     |||||||..    .   |||||.|||....||| ||.|.... |||| .   ..|.
dssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt
0037934 (Phosphotyrosine protein) phosphatases II 1-63 4.7e-15 51.3 In-house 23-83 (243) alignment 
Range on Protein: 1-63
Range on HMM: 23-83/243.0
DHNRVCLRGtrDDYINASFIKDVvptsPCFIATQAPLQPSLND----FWLMVYEQQASIIVMLLSKP
||.||.| |  .|||||..|. .    | .||||.||. ...|    || |..|.. ..|||| .  
dhsrvkleg..sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelv
subfamily_PTPRN_pd Subfamily PTPRN 1-67 6.3e-15 49.6 In-house 69-139 (297) alignment 
Range on Protein: 1-67
Range on HMM: 69-139/297.0
DHNRVCLRG----TRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGK
||.|| |.     ...||||||.| |  | .|..||||.||  .. ||| ||.|| . .||.| .   .| 
dhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegv
subfamily_PTPN3_pd Subfamily PTPN3 1-68 1.2e-14 48.9 In-house 54-124 (280) alignment 
Range on Protein: 1-68
Range on HMM: 54-124/280.0
DHNRVCLRGTRDDYINASFIKDVVPTSP---CFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKV
|. || |. .. |||||....  .|..     .|||| ||. . .||| ||.||..|.|||| .    |.|
datrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrv
subfamily_PTPN6_pd Subfamily PTPN6 1-62 3.8e-14 47.4 In-house 67-132 (306) alignment 
Range on Protein: 1-62
Range on HMM: 67-132/306.0
DHNRVCL--RGT-RDDYINASFIKDVVPTS-PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
||.|| |   ..  .|||||..||. |..|  ..||||  |.  ..||| ||..... .|||.  .
DhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttke
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1-68 6.4e-14 46.7 In-house 54-124 (281) alignment 
Range on Protein: 1-68
Range on HMM: 54-124/281.0
DHNRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKV
|. || .    . .  |||||.|.. .      .||||.|.  ||..|| ||.||..|.|||.  .  .||.
DatrvkvtpneenkntDYinanfvpgy.kgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagkl
subfamily_PTPRG_pd Subfamily PTPRG 1-60 1.7e-13 44.6 In-house 60-123 (563) alignment 
Range on Protein: 1-60
Range on HMM: 60-123/563.0
DHNRVCLRGTRD-----DYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
|. || |... .     |||||..|.     |  ||||| ||.  ..||| |..||...||||. 
drsRvklsplpgkkkklDYinAnyidGy.qkskafiatqgplkdtfddFWrmiWeqnvaiivmit
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-68 2.7e-13 44.4 In-house 59-131 (290) alignment 
Range on Protein: 1-68
Range on HMM: 59-131/290.0
DHNRVCLR---GTRD---DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKV
| ||. ||   | .|   .||||..||.    .  .||||.|..  | ||| ...... .|||||..    |||
ddnritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkv
subfamily_PTPN14_pd Subfamily PTPN14 1-68 3e-13 44.4 In-house 62-133 (300) alignment 
Range on Protein: 1-68
Range on HMM: 62-133/300.0
DHNRVCLRGT---RDDYINASFIKDVVPTS-PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKV
..||| |  |   ...||||| || .| ..   .|..|.||.  ..||| ||.||. ..|||| ..   || 
ednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgke
subfamily_PTPRA_pd Subfamily PTPRA 1-59 4.5e-13 43.8 In-house 71-132 (330) alignment 
Range on Protein: 1-59
Range on HMM: 71-132/330.0
DHNRVCLR---GT-RDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVML
|..|| |    |.   ||||||||.        |||.| |.. ...||| |..||... ||||
dfsrvilsvkeGveesdyinasfidGy.kekdkfiaaqGPkeetvedfwrmiweqksativml
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1-61 4.8e-13 43.7 In-house 60-119 (287) alignment 
Range on Protein: 1-61
Range on HMM: 60-119/287.0
DHNRVCLRGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
| .|| |.|...|||||.||.     .  ||....|.   . .|| .. ... ..||||  
dnyrvllkgehpdyinavfidgy.kekkafiiaesPmfntarnfWkliddrnvtaivmlcq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1-59 1.1e-12 42.7 In-house 61-122 (325) alignment 
Range on Protein: 1-59
Range on HMM: 61-122/325.0
DHNRVCLRGTRD----DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVML
|..||.|   .|    ||||||...| .     |.|.||||  ..||.| .|.. ..|..|.|
dksrvvletkkddpssdyinasylrddk.kkdvflaaqaPltatindlWrlvldWrcsvvvvl
subfamily_PTPN13_pd Subfamily PTPN13 1-69 1.2e-12 42.7 In-house 50-118 (273) alignment 
Range on Protein: 1-69
Range on HMM: 50-118/273.0
DHNRVCLRGTRDdYINASFIKDVVPTS-PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKVS
|. || | .    |||||.||  |      .||.| ||  . .|||.||.||.|..|.|. ..  .||| 
detrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1-59 1.2e-12 42.3 In-house 46-106 (283) alignment 
Range on Protein: 1-59
Range on HMM: 46-106/283.0
DHNRVCLRGTRDDYINASFIK--DVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVML
| .|| |.    |||||.||   .    .  .|..|.||.    ||| ||...... ||||
dqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1-62 1.2e-12 42.6 In-house 64-126 (297) alignment 
Range on Protein: 1-62
Range on HMM: 64-126/297.0
DHNRVCLRGTRDD----YINASFIKDVVPtspCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
| .|| |. . ||    |.||||.| .      .|.|| | . ...||| ||...|.|.||||  .
dssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlndd
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1-60 1.3e-12 42.3 In-house 46-104 (267) alignment 
Range on Protein: 1-60
Range on HMM: 46-104/267.0
DHNRVCLRGTRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
|..|| || . ..|||||.. .   |   ||.|| ||. .  ||. .. .|. ..||.| 
ddtrvilrtkeeeyinasyv.egyktknafivtqdplkntitdfltvihdqkvpvivllt
subfamily_PTPRK_pd Subfamily PTPRK 1-67 2e-12 41.6 In-house 56-125 (314) alignment 
Range on Protein: 1-67
Range on HMM: 56-125/314.0
DHNRVCLRGTRDD----YINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGK
|. || |  . .|    ||||..| |    .  ||.|| |||  ..||| .||..... ||||    ..|.
drsrvflitidgdpssdyinaali.dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1-61 2.8e-12 41.6 In-house 74-137 (319) alignment 
Range on Protein: 1-61
Range on HMM: 74-137/319.0
DHNRVCLRGT----RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
|.|.| |. .      |||||||..        .||.| ||. .|.||| |..|...| ||.|  
dknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivlltk
subfamily_CG7180_pd Subfamily CG7180 1-63 1.3e-11 38.7 In-house 55-120 (296) alignment 
Range on Protein: 1-63
Range on HMM: 55-120/296.0
DHNRVCLR---G-TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKP
|.||| |.   |  ..|||||...   .     .| |.|| . ....|| .||....| .|.|  ..
DynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktf
subfamily_PTPN1_pd Subfamily PTPN1 1-59 1.9e-11 38.2 In-house 45-102 (290) alignment 
Range on Protein: 1-59
Range on HMM: 45-102/290.0
DHNRVCLRGTRDDYINASFIKdVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVML
|| |. |. .  ||||||... .      .| || ||    . ||.||.||..  .|||
dhsrikleradndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvml
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1-60 1.4e-09 32.2 In-house 61-120 (305) alignment 
Range on Protein: 1-60
Range on HMM: 61-120/305.0
DHNRVCLRGTR-DDYINASFIKdvVPTSP-CFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
|.||| |.|.   .|| | ..    || |  || |||||. .  ||| | ....   | || 
dnnrvklegpwpheyihanyvs..tptnpkrfictqaplektcadfwymclqdkveaifmlc
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1-60 2.6e-09 31.4 In-house 46-108 (297) alignment 
Range on Protein: 1-60
Range on HMM: 46-108/297.0
DHNRVCLRG--TRDDYINASFIKDV-VPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
| .|| |..  |  ||||| ..     ..   .| .| ||. ...||| .|.||.  .|||. 
ddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmva
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1-60 1.1e-08 29.3 In-house 51-112 (287) alignment 
Range on Protein: 1-60
Range on HMM: 51-112/287.0
DHNRVCLRGTR---DDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
|..|| |  .     ||||| ..         |||.|.|.  ...||| .|.|.... .... 
ddtrvllsaegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmt
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1-59 4.5e-08 27.0 In-house 61-122 (439) alignment 
Range on Protein: 1-59
Range on HMM: 61-122/439.0
DHNRVCLRG----TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVML
|| || |.         |||| .||    .   .||||.| . . .||| .|.|.... ||||
dhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivml
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1-62 6.6e-08 26.5 In-house 69-128 (290) alignment 
Range on Protein: 1-62
Range on HMM: 69-128/290.0
DHNRVCLR-GTRDDYINASFIKDvvpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
|  || |. |   ||. | ..|    . . || || .|. .  |.| || ..... ||||   
dktrvilkdGydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlcel
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1-61 1.4e-07 25.3 In-house 64-126 (302) alignment 
Range on Protein: 1-61
Range on HMM: 64-126/302.0
DHNRVCLRGTRDDYINASFIKdvVP-TSPCFIATQAPLQPSL---NDFWLMVYEQQASIIVMLLS
|.|.| | .. |.|.||| ..  ||  ..  | .| | . |    ..|| ||....   .|.|. 
dsnlvkleaepdsyvnaskve..vPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvg
subfamily_PTPRB_pd Subfamily PTPRB 2-69 2.6e-15 51.2 In-house 65-135 (293) alignment 
Range on Protein: 2-69
Range on HMM: 65-135/293.0
HNRVCL----RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKVS
|.|| |      . .|||||..|..   .   ||||| ||  ...||| ||.|...||||||      ||| 
hsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvk
subfamily_PTPN12_pd Subfamily PTPN12 2-67 1.5e-13 45.3 In-house 54-122 (290) alignment 
Range on Protein: 2-67
Range on HMM: 54-122/290.0
HNRVCLRGT----RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGK
..|| |. .     .|||||.||| |   .  .||.|.||   |.||| |..|.. .|.||.  .   ||
ksrvelskieeeegsdYinanfikgve.gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-69 4.9e-13 43.6 In-house 58-128 (315) alignment 
Range on Protein: 2-69
Range on HMM: 58-128/315.0
HNRVCL----RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKVS
..|| |        .||||||.|| |  .  ..||.|.||. |..||| ||...... |||.  |    |..
sarvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-62 1.7e-12 42.5 In-house 39-102 (284) alignment 
Range on Protein: 2-62
Range on HMM: 39-102/284.0
HNRVCLRGT----RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
.|.| |. .      ||||||||.        .|||| ||. .|.||| |..|...| ||.|  .
knvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivlltkd
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-72 8.4e-12 39.6 In-house 63-136 (315) alignment 
Range on Protein: 2-72
Range on HMM: 63-136/315.0
HNRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKVSNEK
. || |         ||.||.||.        .||.|.|.  |..||| .|.|.. . |||| .     |   ||
ksrvqlpllendphsdyvnanfidGy.nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaek
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2-61 1.1e-09 32.8 In-house 22-85 (239) alignment 
Range on Protein: 2-61
Range on HMM: 22-85/239.0
HNRVCLR----GTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
|.|| |       . ||||||...|   .  ..||||  ...|  ||| |.....  .||||  
hsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltg
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2-61 1.1e-09 32.8 In-house 21-84 (239) alignment 
Range on Protein: 2-61
Range on HMM: 21-84/239.0
HNRVCLR----GTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
|.|| |       . ||||||...|   .  ..||||  ...|  ||| |.....  .||||  
hsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltg
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2-61 3.4e-06 20.9 In-house 110-170 (244) alignment 
Range on Protein: 2-61
Range on HMM: 110-170/244.0
HNRVCLR-G-TRDDYINASFIKDVVPTSpCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
 ||| |  |   . ||||||.  .  |.  .| || ||  .  ||| |. |.   ..|.| |
fnrvplskgsmgntyinasfvgclgrta.eyiltqhpladtsmdfwkmmlerhvnvlvvlgs
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 3-60 1.7e-15 51.8 In-house 62-122 (288) alignment 
Range on Protein: 3-60
Range on HMM: 62-122/288.0
NRVCLRG----TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
.|| |..    .  ||||||.|..    .  .||||.||. ..|||| .|||...| |||| 
krvklkkleeeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyenktstivmlt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 3-59 4e-15 50.6 In-house 43-104 (274) alignment 
Range on Protein: 3-59
Range on HMM: 43-104/274.0
NRVCLRG-----TRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVML
 ||.|.         .|||| .||    .| ...||| ||.  ..|||.|.|......||||
srvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 3-72 1.3e-14 49.0 In-house 63-135 (319) alignment 
Range on Protein: 3-72
Range on HMM: 63-135/319.0
NRVCLRGT----RDDYINASFIKDvVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKVSNEK
 || |         ||||||||         ||||||||.  ..||| ||.|...||.|||      .||  .|
trvvlseldgvegsdyinasfidg.yqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-67 1.3e-11 38.3 In-house 58-125 (515) alignment 
Range on Protein: 3-67
Range on HMM: 58-125/515.0
NRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGK
.|| |         ||.|||.|. .  .  ..||.|.|.. |..||| .|.... . |.|.  .    |
vrvklevindnPhsdyfnasyipsf.dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 3-61 3.4e-11 37.2 In-house 60-121 (392) alignment 
Range on Protein: 3-61
Range on HMM: 60-121/392.0
NRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
.|| |      . .||.|||.|. .  .  ..||.|.|   ||.||| ||...... |.|.  
arvkleviddipdsdylnasyipsf.dnekayiasqgpnaaslddfwrmvfqenvttiamvtk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 3-61 1.4e-08 29.0 In-house 50-108 (285) alignment 
Range on Protein: 3-61
Range on HMM: 50-108/285.0
NRVCLRGTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
 || |.    ||| ||...        .|.|| ||  .|.||| |.|... . ..|| .
trvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlct
subfamily_Ptp69D_pd Subfamily Ptp69D 4-61 7.2e-13 43.3 In-house 64-124 (307) alignment 
Range on Protein: 4-61
Range on HMM: 64-124/307.0
RVCLRGT----RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
|| |. .      |||||||||     .  ||| |.|..  ..||| |. ||.  .||||  
RvkLkkingkedsdYinasfikgyk.ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsn
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 7-70 1.9e-06 22.1 In-house 62-124 (307) alignment 
Range on Protein: 7-70
Range on HMM: 62-124/307.0
LRGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKVSN
. |   ||| | ..   .     ||..| ||. .  .|| |. ...   ..||     ..|.  
fdglasdyihanylgiai.kpkkficaqgplentqysfwamaiqekvesvimlckvielakikc
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 9-60 7.5e-12 40.0 In-house 69-121 (305) alignment 
Range on Protein: 9-60
Range on HMM: 69-121/305.0
GTRD--DYINASFIKDvVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
 . |  ||||||...     . ..|..|.||.  ..||| ...| . | |||| 
eslddsdyinasyvdg.ykrkkkyivaqgPlkntvadfWrliveekvstivmlt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 10-68 7.3e-15 49.8 In-house 72-129 (318) alignment 
Range on Protein: 10-68
Range on HMM: 72-129/318.0
TRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKV
.  |||||..|      .  .||.||||   ..||| ||.||....||||  .   ||.
egsDyinanyidGy.rrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergka
subfamily_PTPN9_pd Subfamily PTPN9 10-63 3.6e-12 40.9 In-house 68-120 (297) alignment 
Range on Protein: 10-63
Range on HMM: 68-120/297.0
TRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKP
.  |||||.|. |      .||||| ||.   .|||.||.||.. .|||     
easdyinanfv.dGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvv
subfamily_ptpA1_pd Subfamily ptpA1 10-61 7.9e-10 33.0 In-house 69-122 (418) alignment 
Range on Protein: 10-61
Range on HMM: 69-122/418.0
TR----DDYINASFIKDVVPTSpcFIATQAPLQPSLNDFWLMVYEQQASIIVMLLS
 .     ||||| .|    |    ||.|| ||  .. ||| ||.|... |||||  
iqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmvwenrcriivmlsr
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 10-67 1.1e-09 32.4 In-house 68-124 (301) alignment 
Range on Protein: 10-67
Range on HMM: 68-124/301.0
TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGK
.. .|||||.|...   .  |||.|.|..  | ||| ...... . |||.  .  . |
cqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 10-62 5.3e-08 26.8 In-house 77-128 (310) alignment 
Range on Protein: 10-62
Range on HMM: 77-128/310.0
TRDDYINASFIKDVVPTSpCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
  .||| | ..|     |  || .| ||| .. ||| |.....|  |..|   
ryedyihanyvktnylrs.tficsqgplqhtiidfwrmifqeraesilllckv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 11-59 2.7e-10 34.7 In-house 47-95 (270) alignment 
Range on Protein: 11-59
Range on HMM: 47-95/270.0
RDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVML
.  |||| ... .   .  .||...||. .|..|| |..|.... |||.
ataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmt
subfamily_CG42327_pd Subfamily CG42327 11-68 3.2e-10 34.2 In-house 55-113 (319) alignment 
Range on Protein: 11-68
Range on HMM: 55-113/319.0
RDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATG-KV
.| |..||...    .   .||.|..|. |  ||| .|.|||. .|| | .    | ||
kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikv
subfamily_egg_pd Subfamily egg 11-63 1.2e-09 32.3 In-house 67-118 (307) alignment 
Range on Protein: 11-63
Range on HMM: 67-118/307.0
RDDYINASFIKDvVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKP
 ||.| |  .|   |    || .||||. . .||| ||....   |||| |. 
lddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrk
0043147 (Phosphotyrosine protein) phosphatases II 11-62 1.9e-08 29.8 In-house 4-54 (172) alignment 
Range on Protein: 11-62
Range on HMM: 4-54/172.0
RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
..||||||... ..   . |||||.||.  |.||| |..|.. ..||.| . 
gsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel
0041856 (Phosphotyrosine protein) phosphatases II 11-60 5.5e-08 28.1 In-house 18-66 (182) alignment 
Range on Protein: 11-60
Range on HMM: 18-66/182.0
RDDYINASFIKDVVPTSPcFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
  |||||...    |..  |||||.||. ...||. |..|.. ..||.| 
dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt
0049772 (Phosphotyrosine protein) phosphatases II 11-58 7.3e-08 28.0 In-house 71-126 (314) alignment 
Range on Protein: 11-58
Range on HMM: 71-126/314.0
RDDYINASFIKDVvptsPCFIATQAPLQPSLNDF----------WLMV--YEQQASIIVM
  ||||||... .      |||||.||.  ..||          | ||  ....  .|||
gsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 11-68 5.4e-07 23.5 In-house 79-136 (305) alignment 
Range on Protein: 11-68
Range on HMM: 79-136/305.0
RDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKV
  ||| | ..   .     ||..| ||. ....|| || ...   ||||     .||.
psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgkl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 11-60 5.1e-06 20.2 In-house 69-117 (347) alignment 
Range on Protein: 11-60
Range on HMM: 69-117/347.0
RDDYINASFIKdVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
 . ||||| ||    .|  .| || ||  .. ||| ||.  . . .| ..
vetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 12-62 1.8e-09 31.8 In-house 83-138 (350) alignment 
Range on Protein: 12-62
Range on HMM: 83-138/350.0
DDYINASFIKDV---VPTSPCF--IATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
.|||||...|     |   | |  |||||||.  ..||. .... .  .|..| |.
nDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsd
0036282 (Phosphotyrosine protein) phosphatases II 12-64 1.3e-07 27.0 In-house 2-48 (174) alignment 
Range on Protein: 12-64
Range on HMM: 2-48/174.0
DDYINASFIKDVVPTSpCFIATQAPLQpslndFWLMVYEQQASIIVMLLSKPA
.||||||... .. |.  .||.|.||.     || |..|.. ...||||.   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleeke
0051429 (Phosphotyrosine protein) phosphatases II 12-69 5.4e-07 25.1 In-house 4-62 (272) alignment 
Range on Protein: 12-69
Range on HMM: 4-62/272.0
DDYINASFIKDVvpT----SPCFIATQAPLQPSLNDFWLMvYEQQASIIVMLLSKPATGKVS
..||||....    .       ......||. . .||| . .|.. . ||.| |    |.. 
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlk
0046846 (Phosphotyrosine protein) phosphatases II 13-62 1e-06 24.2 In-house 13-57 (176) alignment 
Range on Protein: 13-62
Range on HMM: 13-57/176.0
DYINASFIKDvvptsPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
|||||..|       ...||||.||  .| ||. |..|.. ...|.|.. 
dyinanlilg.....srpiatqgplprtladflemlkelgitavvnltee
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 27-62 1.6e-06 22.1 In-house 89-124 (301) alignment 
Range on Protein: 27-62
Range on HMM: 89-124/301.0
SPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSK
.  |||||.||. . .||| |.   .   ||||  |
phrfiatqgPlkntsedfwamlvqydvekivmlgqk
subfamily_PTPN1_pd Subfamily PTPN1 67-303 1.5e-49 163.3 In-house 33-272 (290) alignment 
Range on Protein: 67-303
Range on HMM: 33-272/290.0
KVSNEKQDID--DHNRVCLRGTRDDYINASFIKdVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLlsKPATGKGSTNFVSYWPEDKG-AAQKFG
.  |  .|.   || |. |. .  ||||||... .      .| || ||    . ||.||.||..  .|||       |...  ..|||...   . .. 
rnlnryrdvspydhsrikleradndyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvml..nkvvekeqikcaqywPqgeeekellle

--DISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtQIPIVVHCSAGIDRTGVFCLVYTAAREI
   ..| | |. ...|.. |...|. | |.. |.|.|  .|.||.||||.||. .|.|. .|..  | ... . | |.|||||| |.| |||| |   .|
dtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssd.vGpavihcsaGiGrsGtfclvdtclvli

KEGHG--IADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
.. .     || .|. .|| .|  .|  ..||.||| |||  |.
ekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 69-300 5.5e-41 135.3 In-house 36-264 (283) alignment 
Range on Protein: 69-300
Range on HMM: 36-264/283.0
SNEKQDI--DDHNRVCLRGTRDDYINASFIK--DVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLlSKPATGKgSTNFVSYWPEdKGaAQKFGD
 | .|.|   | .|| |.    |||||.||   .    .  .|..|.||.    ||| ||...... |||| .|   ..   .   |||. .| ....|.
knrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml.tklqedl.rikCsqyWPk.rG.sedyGe

ISVSLQSKRTTDYHVERIIHLTHL-PTRQMRTITHLQFTAWPEFGVPSSPGVLLQFiDEVQSYhsQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKE
  |.|.   | .  . . . | .   ...   ..| |.  | |.|  .    |..| . |.|   |... . |||||||.|| ||.||. . ..  ... 
ftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvisl..qteskkgPivvhCstgiGrtavfiaasasvkdalt

gHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
 . . |...||| .| ||  .. ...| |. ....| 
.esvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 69-314 5.2e-21 69.3 In-house 56-297 (302) alignment 
Range on Protein: 69-314
Range on HMM: 56-297/302.0
SNEKQDIDDHNRVCLRGTRDDYINASFIKdvVP-TSPCFIATQAPLQPSL---NDFWLMVYEQQASIIVMLLSKPATGKgstNFVSYWPEDKGAAQKFGD
 .|. .| |.|.| | .. |.|.||| ..  ||  ..  | .| | . |    ..|| ||....   .|.|. .    |    .  ..|.  |. ...|.
qsedvpildsnlvkleaepdsyvnaskve..vPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk...tlselfpkksgdykeygk

ISVSLQSKRTTDYHVeRIIHLTHLP----TRQMRTITHLqfTAWPEFGVPSSPGVLLQFIDEVqsyHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAARE
. |  .    .. ..     .  ||       . ....|  | |..  || . . | . . .|   . .. |.. ..|.    |. | |.|  . .|  .
mfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvl..tnWkqkkvpvkyaeliktaakv...fakkikadentvivSknGaGRagafltlavavek

IKEGhGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHALAKRGVATK
...|     | ..||..| ||  ..   .|  . | |.|.| .. . |  . .|
lqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkk
subfamily_PTPN23_pd Subfamily PTPN23 70-310 1.9e-119 392.8 In-house 47-288 (288) alignment 
Range on Protein: 70-310
Range on HMM: 47-288/288.0
NEKQDI--DDHNRVCLRGTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKGSTNfvSYWPEDKGAAQKFGDISV
| ..||  .|||||.|||..||||||||.||..|..|.|||||||||..|||||||||||..|.|||||||...|| ...  .|||||||...||||.||
nrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd..rYwPedkgetvkfgdlsv

SLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQS-YHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHG
.|.|.|.|..||||...|..|.........|||.|.|||.|||.||..||||.|||.| |...|||...|.|||||||..|||||.|||.|.||...|.|
tlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgng

IADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHALAKRG
..||.|||..|| |||.|..|||||||||.|.|..||..| |||
lldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkrG
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 71-301 3.6e-55 182.2 In-house 55-282 (305) alignment 
Range on Protein: 71-301
Range on HMM: 55-282/305.0
EKQDIDDHNRVCLRGTRD--DYINASFIKDvVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFGDISVS
   . ||. ..  . . |  ||||||...     . ..|..|.||.  ..||| ...| . | ||||      ||       |||| |.  ..||..|| 
itlldddriiltekeslddsdyinasyvdg.ykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggk..dkCrqYWpesktekkefgefsve

LQSKRTTDYHVERIIHLTH-LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtqIPIVVHCSAGIDRTGVFCLVYTAAREIKEGhGI
|.|..|.  ..|| ....     .. ||....|.| ||. ||| ... ||..|..||  ......   |..||||||. |||||. |  |   .|.  ..
lksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg..vpllVhCsagvgRtGvfiavdialerlkkE.ev

ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
 |. .|.|.|| .|  |.....|  | .||.  .
vdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 74-155 5.9e-07 23.1 In-house 85-156 (349) alignment 
Range on Protein: 74-155
Range on HMM: 85-156/349.0
DiddhnrvclRGTRDDYINASFIKD-VVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPED
|          |  |||||| ..|   . .   .|||||||  ...||. ..  ..  ... | .  ...     .  || | 
d.........sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl..ekcdiywqel
Y_phosphatase Protein-tyrosine phosphatase 75-299 5.9e-61 201.3 Pfam-A 12-234 (235) alignment 
Range on Protein: 75-299
Range on HMM: 12-234/235.0
IDDHNRVCL--RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFGDISVSLQ--
. |..|| |  .... |||||...|    ..  |||||.||. ...||| ||.... ..|||| |    |.  ...  ||||...  ...|||.| |.  
pydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr..ekcaqYwpeeeeesltygdikvelkek

SKRTTDYHVERIIHLTHLPTRQ-MRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGiAD
.|. ..  . | ..|..  ...  |....|..|.||. |||.||  ||..|..|....   .... |.|||||||. |||.|... .. .......   |
ekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.vd

IPQVVKKLRLQRRWMISEKEQLKFSYDAIL
. |.||.|| ||. |... ||..| |.|||
vlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 75-299 5.9e-61 201.3 In-house 12-234 (235) alignment 
Range on Protein: 75-299
Range on HMM: 12-234/235.0
IDDHNRVCL--RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFGDISVSLQ--
. |..|| |  .... |||||...|    ..  |||||.||. ...||| ||.... ..|||| |    |.  ...  ||||...  ...|||.| |.  
pydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgr..ekcaqYwpeeeeesltygdikvelkek

SKRTTDYHVERIIHLTHLPTRQ-MRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGiAD
.|. ..  . | ..|..  ...  |....|..|.||. |||.||  ||..|..|....   .... |.|||||||. |||.|... .. .......   |
ekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee.vd

IPQVVKKLRLQRRWMISEKEQLKFSYDAIL
. |.||.|| ||. |... ||..| |.|||
vlqivkelRkqRpgmvqsleqYiflykail
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 75-303 5.4e-48 158.3 In-house 57-284 (290) alignment 
Range on Protein: 75-303
Range on HMM: 57-284/290.0
IDDHNRVCLR---GTRD---DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDkGAAQkFGDISVS
. | ||. ||   | .|   .||||..||.    .  .||||.|..  | ||| ...... .|||||..    ||  ..   |||.  .... .| .|. 
vyddnritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegk..vkCqqYWpds.dtka.ygefsik

LQSKRTTDYHVERIIHLTHLPT-RQMRTITHLQFTAWPEFG-VPSSPGVLLQFiDEvqSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGhG
|.. .|... .|| .....  .  . ...|..|.|.|.. | |.   ..||..  |   |. | .... .||||||... |..||| ..|.    |   |
llneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi.ee..myktqrkrgntsivvHCSdtvgrsavfcaaattinkckte.g

IADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
  |. ||.|..| |.  ..  ..|... .. .| |  
vidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 75-299 3.1e-43 142.7 In-house 14-236 (237) alignment 
Range on Protein: 75-299
Range on HMM: 14-236/237.0
IDDHNRVCLRGT--RDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGaAQKFGDISVSLQSK
  ||.|| |.|.    |||||...|..  |   .||.| ||..| .||| ||.... |.||||       .       |||. .   . .| ..|||. |
aydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltglie..gnelkchkywpstdq.paaygvltvslkkk

R-TTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIADIP
   .|| |  ..  ..|  ...| |   |||.||. |||     ||.|  ..   .|.      | ..|||||. |||.| .. .  |. || . . || 
eefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniin.rsphvsesgpwiihcsagvgrtgiflvidamlrqakekk.vvdiy

QVVKKLRLQRRWMISEKEQLKFSYDAIL
. |. .  .| ..|  |.|  | ...||
nyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 75-285 5.8e-29 95.7 In-house 67-266 (290) alignment 
Range on Protein: 75-285
Range on HMM: 67-266/290.0
IDDHNRVCLR-GTRDDYINASFIKDvvpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFGDISVSLQSKR
 .|  || |. |   ||. | ..|    . . || || .|. .  |.| || ..... ||||      ||  .    |.|| .| .  ||.|.|    . 
cndktrvilkdGydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGk..akceqyypekeGevltfGeitvlcseed

TTDYHV-ERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVqsyhsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQ
. | ..  ... . .  . .   . ||.  .||.  |. |   ||. .  .       ||.  |.|||||||| ||| |  . .... . .|. . |. .
dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril.......rkasGpvvvhcsaGiGrtGtfvaievglqilldGkel.dlld

VVKKLRLQRRWMI
.|. ||  |   .
lvralrnsrlnsv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 75-223 4e-25 83.3 In-house 42-193 (297) alignment 
Range on Protein: 75-223
Range on HMM: 42-193/297.0
I--DDHNRVCLRG--TRDDYINASFIKDV-VPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSYWPEDKGAAQKFGDISVSL
|   | .|| |..  |  ||||| ..     ..   .| .| ||. ...||| .|.||.  .|||.        |    . |||. ..  .| ||. |  
ilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqed..Grdkcapywpsvvqerlkagdvvvef

QSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEV
 |. . ...   .  |. .   . | ..| || .||. ||||    | .|  .|
lsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_egg_pd Subfamily egg 75-306 1.2e-17 58.6 In-house 51-274 (307) alignment 
Range on Protein: 75-306
Range on HMM: 51-274/307.0
IDDHNRVCLRGT----RDDYINASFIKDvVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkgsTNFVSYWPEDKGAAQKF--GDISVS
  |  || |.       ||.| |  .|   |    || .||||. . .||| ||....   |||| |.  .     .   |||  .  . ..  | . . 
ckdssrvklelrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes....erceyywpkaesdslvtvpGslrie

LQSKRTTDYHVERIIHLTHL-PTRQMRTITHLQFtAWPEFGVPSSPGVLLQfidevqsyhsQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGhGI
      .   . |. .|  . . .. | . | |   . . .   ||  .|.          . |.   |.||..  |. .....  . .|  ..  |  |
nlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlr..........klrnlskpvvvqdilGvskaatlvaieiallsllrG.pi

--ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHAL
    . . |. |||.||  ..   .  | |  .| . |  .
tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi
0043336 (Phosphotyrosine protein) phosphatases II 76-301 1.7e-59 196.9 In-house 57-276 (278) alignment 
Range on Protein: 76-301
Range on HMM: 57-276/278.0
DDHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPedkGAAQKFGDISVSLQS
 ||.||.|  .     .||||||.. |. . .. |||||.||. ...||| ||.|.. ..|||| .     .|..... |||   |  ...||..| |..
ydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelve..lgrvkcaqYwp...ggsltygdftvtllk

KRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIADIP
  . |. . | ...|.| . . ||.||.....||..|||.|.  ||.|. .|... .   . . |..||||||..|||.|...|.. . .. ..   |..
eehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdle

QVVKKLRLQRRWMISEKEQLKFSYDAILCY
..||.|| || ...   .|..| |.|.|.|
eavkelreqRpgavqtpsqyrflyealley
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 76-302 1.9e-43 143.5 In-house 59-278 (287) alignment 
Range on Protein: 76-302
Range on HMM: 59-278/287.0
DDHNRVCLRGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSYWPEDKGaaQKFGDISVSLQSKRTT
 | .|| |.|...|||||.||.     .  ||....|.   . .|| .. ... ..||||  .  .         ||||.|     .|. ...| .. ..
pdnyrvllkgehpdyinavfidgy.kekkafiiaesPmfntarnfWkliddrnvtaivmlcqeken..deevcyqyWpeeks..vvlGeyniellneevn

DYHVERIIHLTHLP-TRQMRTITHLQFTAWPEFG-VPSSPGVLLQFiDEvqSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEgHGIADIPQV
.  .|| .....   . . ....  |.|.|.. | |..   .||.. .|   |..|..... .||||||... |...|| . |. .. |.  |. |. ||
agyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi.ee..myktqrkrgntsivvhCsdtvGrsamfcaaattinkckt.eGviDvfqv

VKKLRLQRRWMISEKEQLKFSYDAILCYA
.|. | |.  ..   || || .|..| | 
lksqriqkpgsvqtveqykfindivleyl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 76-304 1e-29 98.3 In-house 60-289 (305) alignment 
Range on Protein: 76-304
Range on HMM: 60-289/305.0
DDHNRVCLRGTR-DDYINASFIKdvVPTSP-CFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDKGAAQKFG----DISVSL
 |.||| |.|.   .|| | ..    || |  || |||||. .  ||| | ....   | ||       ||.   . |.. ...   .|      ||| .
ldnnrvklegpwpheyihanyvs..tptnpkrfictqaplektcadfwymclqdkveaifmlcn..llekgakkcleyfaskdkdvlefeekgqkisvkf

QSKRTTDYH------VERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDevqsyhsQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKE
.|  | ...      |.. . .   |  ..| .||  .  ||. |||..   .|...        . | .. |||||||||| |||   ..     .. .
essvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelle.......karpskgpivvhcsagigrtgsvvmleyildqlla

GHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
|. | |  ....|.| ||   |   .|  | .. || | |.
gqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
0050432 (Phosphotyrosine protein) phosphatases II 77-304 3.6e-69 228.8 In-house 81-301 (308) alignment 
Range on Protein: 77-304
Range on HMM: 81-301/308.0
DHNRVCLrGTRDDYINASFIKDVV-PTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKG-AAQKFGDISVSLQSKRT
||.||.| .  .||||||...  .   .  |||||.||. ...||| ||.||. ..|||| .     .|  ..  |||.. |   ...|...| | |  .
dhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklve..ngrekcaqYwplelgggsleygkftvtllseev

TDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsqqrkTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGhGIADIPQVV
 |... | ..||.| . ..||.||...|.||..|||.||  ||.|...|....      . |||||||||. |||.|...... . .... |  |....|
lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeav

KKLRLQRRWMISEKEQLKFSYDAILCYARH
|||| ||  |.  .||..| |.|.|.|.. 
kklReqRpgmvqtpeqylflyralleylkl
0036941 (Phosphotyrosine protein) phosphatases II 77-304 6.3e-67 221.3 In-house 52-279 (297) alignment 
Range on Protein: 77-304
Range on HMM: 52-279/297.0
DHNRVCLRGTRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGAAQKFGDISVSLQSKRT--
||.||.| .  .||||||.. |.   .  |||||.||. ...||| ||.||. ..|||| .     .|  .. .|||...|  ...||..| |.|  .  
dhtRVklddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelve..lgrekcaqywpleegesltygdftvtllsvevvl

TDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKE--GHGIADIPQ
 |. . | ...|.. . . ||.||...| ||..|||.||  ||.||..|......    . |..||||||. |.|.|...... . ...   .|  ||..
lddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll.psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdile

VVKKLRLQRRWMISEKEQLKFSYDAILCYARH
.||||| || ...   ||..| |.|.|.. ..
avkklReqRpgavqtleqyrflyeallellkk
0046845 (Phosphotyrosine protein) phosphatases II 77-304 1.2e-65 217.1 In-house 41-276 (284) alignment 
Range on Protein: 77-304
Range on HMM: 41-276/284.0
DHNRVCLRG-----TRDDYINASFIKDVV----PTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDkGAAQKFGDISV
||.||.|.        .||||||...        ... |||||.||. ...||| ||.||....|||| .     .| . .  |||.. |  ...||..|
dhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelve..ngrekcaqYwple.gevltygdftv

SLQSKRTTDYHVERIIHLTHLP-TRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHG
 | |. . |... | . ||.|  | . ||.||...|.||..|||.||  ||.|...|...... .... |||||||||. |||.|...... . ..... 
tllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekegl

--IADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
    |....||.|| ||  |.   ||..| |.|.| |...
llgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0051299 (Phosphotyrosine protein) phosphatases II 77-302 1.3e-65 217.1 In-house 62-286 (288) alignment 
Range on Protein: 77-302
Range on HMM: 62-286/288.0
DHNRVCLRG----TRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEdkGAAQKFGDISVSLQSK
||.||.|.       .||||||.| |. ...  |||||.||. ...||| ||.||. ..|||| .     .| ...  |||.  |  ...|||.| | | 
dhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklve..lgrekcaqYwpl..ggsltygditvtllse

RTTDYHVERIIHLTHL----PTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGhGIA
 . |. . | ...|.|    .. . ||.||...|.||..|||.||  ||.|. .|.....   ... |.|||||||..|||.|...... . .... |  
evlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke.ggv

DIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
|....||.|| ||  |.   ||..| |.|.| |.
dvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 77-302 1.7e-65 216.5 In-house 51-272 (273) alignment 
Range on Protein: 77-302
Range on HMM: 51-272/273.0
DHNRVCLRGTRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGA-AQKFGDISVSLQSKRTT
||.||.| .  .||||||.. |. .... |||||.||. ...||| ||.||....|||| .     .|  ..  |||.. |   ...|...| | |  | 
dhsrvklgdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve..lgrekcaqYwpleggelsltygkftvtllseetk

DYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKTqIPIVVHCSAGIDRTGVFCLVYTAAREIKEGhGIADIPQVVK
|... | . ||.| | . ||.||...| ||..|||.|.  ||.||..|...... ..   |.|||||||. |||.|...... . .... |  |....||
ddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavk

KLRLQRRWMISEKEQLKFSYDAILCYA
.|| ||  |.   ||..| |.|.| |.
llrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRD_pd Subfamily PTPRD 77-301 1.2e-64 213.9 In-house 61-280 (564) alignment 
Range on Protein: 77-301
Range on HMM: 61-280/564.0
DHNRVCLRGTRD----DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDkGaAQKFGDISVSLQSK
||.||.|. ..     ||||||||.    ..  .||||.||.....||| ||.||. |.|||| .     || . . .||||. |  ...|.. |.|...
dhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltk..leEkgkvkchkYWPek.g.tetygeltVtleee

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsQqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEgHGIADIPQ
 .  . . | . |..  ....|.... .||.||. ||| |.  ||..|..|.... .  ... |||||||||. |||.|. .    . |||  .  || |
eeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e..pdagPivVhCSaGVGRTGtfividamlerike.ektvDiyq

VVKKLRLQRRWMISEKEQLKFSYDAILCY
.||.|| ||  |. ..||  | ..||| .
yvkalrkqRnamVqteeQYiFiheailea
0040438 (Phosphotyrosine protein) phosphatases II 77-303 1.5e-63 210.3 In-house 56-277 (317) alignment 
Range on Protein: 77-303
Range on HMM: 56-277/317.0
DHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEdkGAAQKFGDISVSLQSK
||.||.|  .     .||||||.. |.   .. |||||.||. ...||| ||.||. ..|||| .     .|  ..  |||.  |  ...||..| |.| 
dhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLtelee..lgrekcaqYwpl..getltygdftvtllse

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIADIPQ
 . .. . | .....| . . ||.||...|.||..|||.||  ||.|...|... .   . . |..||||||..|||.|...|.. . .....   |...
eelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdvee

VVKKLRLQRRWMISEKEQLKFSYDAILCYAR
.||.|| ||. ..   ||..| |||.|.| .
avkelreqRpgavqtpeqyrflydalleylk
0045450 (Phosphotyrosine protein) phosphatases II 77-301 2.4e-61 203.5 In-house 68-303 (307) alignment 
Range on Protein: 77-301
Range on HMM: 68-303/307.0
DHNRVCLRG-----TRDDYINASFIKDVV-------PTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPatGKGSTNFVSYWPEDkGAAQKFGD
||.||.|         .||||||.... .         .  |||||.||. ...||| |..||. ..|||| .     .|.   . |||.. |  . .|.
dhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelv..elgrekcaqywPde.geeltygn

ISVSLQSKRTTDYHVERIIHLTHL-PTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKE
. | | |. . |. . | ...|.| .| . ||.||...|.||..|||.|.  ||.||.||......  . . |..||||||..|||.|.. |.. | ...
ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlek

GHGI--ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
.. .   |....||.|| || ...   ||..| |.|.| .
egtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 77-303 3e-61 202.8 In-house 69-290 (297) alignment 
Range on Protein: 77-303
Range on HMM: 69-290/297.0
DHNRVCLRGTR-----DDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgstNFVSYWPEDKGaaqKFGDISVSLQS
||.||.| . .     .||||||...    ... |||||.||. ...||| ||.||. ..|||| .    |.    ...||||. |   ..||..| | .
dhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr...kcaqywpeegg...tygdftvtllk

KRTTDYHVERIIHLTHlpTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGhGIADIP
  . |. . | ...|.  . . ||.||.|.| ||..|||.|. .||.|...|......  . . |..||||||..|||.|.. |.. . .... |  |..
vehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvl

QVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
..||.|| ||....   .|..| |||.| . .
eavkelreqRpgavqtpsqyrflydallellk
DSPc_SM00195 77-302 2.2e-60 199.6 In-house 39-262 (263) alignment 
Range on Protein: 77-302
Range on HMM: 39-262/263.0
DHNRVCLRGT----RDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSYWPEDKGAAQKFGDISVSLQSK
||.|| |  .     .|||||..||     .  .||||.||.  ..||| ||.|.. .||||| .      |...  .||||..|  ..||.||| |...
dhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen..gkekcdrywpeesggketfgkisvklvev

RTTD-YHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrktQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGiADIP
 ...   . | ..||.  ... |..|..|...||. |||.|.  .|... .|.. .|..   . |||||||||..|||.|... .. ....|..   || 
ekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdif

QVVKKLRLQRRWMISEKEQLKFSYDAILCYA
..||.|| ||  |....||..| |.||| |.
eivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 77-302 2.2e-60 199.6 In-house 39-262 (263) alignment 
Range on Protein: 77-302
Range on HMM: 39-262/263.0
DHNRVCLRGT----RDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSYWPEDKGAAQKFGDISVSLQSK
||.|| |  .     .|||||..||     .  .||||.||.  ..||| ||.|.. .||||| .      |...  .||||..|  ..||.||| |...
dhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen..gkekcdrywpeesggketfgkisvklvev

RTTD-YHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrktQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGiADIP
 ...   . | ..||.  ... |..|..|...||. |||.|.  .|... .|.. .|..   . |||||||||..|||.|... .. ....|..   || 
ekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdif

QVVKKLRLQRRWMISEKEQLKFSYDAILCYA
..||.|| ||  |....||..| |.||| |.
eivkelRkqRpgmvqtleqYlfiyeaileyi
0045098 (Phosphotyrosine protein) phosphatases II 77-303 4.9e-58 192.1 In-house 46-273 (278) alignment 
Range on Protein: 77-303
Range on HMM: 46-273/278.0
DHNRVClrgtrdDYINASFIKDVvptSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEdkGAAQKFGDISVSLQSKRTTD
||.||.      ||||||.|.     .. |||||.||.  ..||| |..|.. ..|||| .   . .|   .. ||||  |  . .||..| |.|  ..|
dhsrVk......dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmlte..lvelgrekcaqywpe..ggsltygdftvtllseevld

YHVERIIHLTHL----PTRQMRTITHLQFTAWPEFGVPSSP--GVLLQFIDEVQSYHS----------QQRKTQIPIVVHCSAGIDRTGVFCLVYTAARE
. . | ...|.|    .. . |..|||... ||..||||.|    .|...........          ..   . |..||||||..|||.....|.  . 
dytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlel

IkegHGIADIPQVVKKLRLQRRW-MISEKEQLKFSYDAILCYAR
.   .|  |....||.|| ||.  ..  .||..| |...| . .
l...eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0040439 (Phosphotyrosine protein) phosphatases II 77-301 1.7e-57 190.3 In-house 24-245 (249) alignment 
Range on Protein: 77-301
Range on HMM: 24-245/249.0
DHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSYWPEdkGAAQKFGDISVSLQSK
||.||.|  ..    .||||||.| |.   .. |||||.||. ...||| |..|.. ..|||| |      |  ..  |||.  |  ...||..| | | 
dhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel..grekcaqywpl..ggsleygdftvtllsv

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGiADIPQ
 . |. . | ..||.| . . ||..|.|.| ||..|||.|.  ||.||..|......  ... |..||||||..|||.|.. |.. . ... .|  |...
evkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelg.vdlee

VVKKLRLQRRWMISEKEQLKFSYDAILCY
.||.|| ||....   ||..| |.|.| .
avkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 77-301 1.3e-56 187.1 In-house 22-242 (245) alignment 
Range on Protein: 77-301
Range on HMM: 22-242/245.0
DHNRVCLRGTR----DDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEdkGAAQKFGDISVSLQSK
||.||.|  .     .||||||.. |.   .| |||||.||. ...||| |..|.. ..|||| .     .|  ..  |||.  |  ...||..| | | 
dhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeee..lgrvkcaqywpl..gesltygdftvtllse

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQ
 . |. . |....|.|.. . |...|.... ||..|||...  ||.|...|... ..  . . |..||||||..|||.|...|.... ... .|. ....
ehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgv.slee

VVKKLRLQRRWMISEKEQLKFSYDAILCY
.||.|| ||....   .|..| |.|.| .
avkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPN3_pd Subfamily PTPN3 77-300 4.4e-55 181.6 In-house 54-273 (280) alignment 
Range on Protein: 77-300
Range on HMM: 54-273/280.0
DHNRVCLRGTRDDYINASFIKDVVPTSP---CFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVSYWPEdKGAAQKFGDISVSLQSKR
|. || |. .. |||||....  .|..     .|||| ||. . .||| ||.||..|.|||| .   . .| .    |||| ..  ...|..|| .....
datrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl..verGrvkChqyWPe.tedeleygefsvkceked

TTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAReIKEGHGIADIPQV
.|  .| | . |..  |.. |.|..||..|||. |||...  .|.|...|....   . .. |.||||||||.||||. |. ||   . | .    ....
etksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr...sgkeePvvvhCsaGigrtGvlilletala.lieaaepvypldi

VKKLRLQRRWMISEKEQLKFSYDAILC
|...| ||  ..  ..| ||  .||| 
vrtmrdqramlvqtasqykfvCeailk
0037934 (Phosphotyrosine protein) phosphatases II 77-301 6.5e-55 181.7 In-house 23-241 (243) alignment 
Range on Protein: 77-301
Range on HMM: 23-241/243.0
DHNRVCLRGtrDDYINASFIKDVvptsPCFIATQAPLQPSLND----FWLMVYEQQASIIVMLLSKPATgkGSTNFVSYWPeDKGaaqKFGDISVSLQSK
||.||.| |  .|||||..|. .    | .||||.||. ...|    || |..|.. ..|||| .      |  . . ||| ..     .||..| | | 
dhsrvkleg..sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvEl..grekcaqywp.gev...tygdftvtllse

RTTDYHVERIIHLTHLP-TRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQ-----QRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIkeghG
...|. . | ..|..|. . . |...|.....||..|||.||  ||.|.|||... ..     ..... |..||||||..|||.... |.  . .    |
ehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....g

iADIPQVVKKLRLQRRW-MISEKEQLKFSYDAILCY
  |. ..||.|| ||   ..   .|..| |.|.|..
.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN9_pd Subfamily PTPN9 77-304 2.4e-54 179.4 In-house 55-292 (297) alignment 
Range on Protein: 77-304
Range on HMM: 55-292/297.0
DHNRVCLRG----TRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDKGAAQKFGDISVSLQSK
|. || |      .  |||||.|. |      .||||| ||.   .|||.||.||.. .|||        .|      |||........|||.|||  . 
detrvvlakvdedeasdyinanfv.dGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttr..vvergrlkcgqyWpleeessaefgdlsvsnvev

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQ----------RKTQIPIVVHCSAGIDRTGVFCLVYTAAREIK
.... ...|......  |...|..|| ||..||..|||||   ||.....|... ..           . .. |||||||||| ||| |. .  .  ...
eeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle

EgHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
|  | .|. ..||.|| || ..|   || .| | |.| || .
e.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 77-301 2.5e-54 179.5 In-house 69-289 (298) alignment 
Range on Protein: 77-301
Range on HMM: 69-289/298.0
DHNRVCLRG----TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLlsKPATGKGSTNFVSYWPEDKgaAQKFGDISVSLQSK
|. || |.        |||||||..     .. ||||||||.....||| || |.... ||||  .. . .. |..  |||...  ....|.|.|||.||
dssRvvLekedadeesdYiNAsflhayk.grnafiatqaPltetvedFWrmvteedigtiVml..tnleeldktkyhkywPdeg..ketygeitvsllsk

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyhSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQ
 .    . | .....  ... |.. .|.|| ||. |||.    .|.....|.   |||.  . |..|.||||..|.| |. ...    .|. . . |. |
eefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra..sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv.Dvfq

VVKKLRLQRRWMISEKEQLKFSYDAILCY
||| || .|  ..  .|| .| |.|.| .
vvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_PTPRB_pd Subfamily PTPRB 77-303 3.5e-54 178.8 In-house 64-286 (293) alignment 
Range on Protein: 77-303
Range on HMM: 64-286/293.0
DHNRVCL----RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDKGaAQKFGDISVSLQSK
||.|| |      . .|||||..|..   .   ||||| ||  ...||| ||.|...||||||       || .    |||.|.  .. .|||.|.|...
dhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrmvwekkssiivmltq..lvekgkvkCeeYWPadee.pvlyGdikvtlvae

RTTDYHVERIIHLTHlpTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEgHGIADIPQ
.... .| | .....  ....|......||.||..|||...  ||.|. .|..... . ... |||||||||. |||.|  . .  ..|.| . . ||  
eeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaie.ktaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifg

VVKKLRLQRRWMISEKEQLKFSYDAILCYAR
.| .|| .| ...  ..|  | ....| . |
ivaelReeRnllvqtekqYifihqcvldllr
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 77-303 2.2e-53 176.2 In-house 54-277 (281) alignment 
Range on Protein: 77-303
Range on HMM: 54-277/281.0
DHNRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKgAAQKFGDISVSLQSK
|. || .    . .  |||||.|.. .      .||||.|.  ||..|| ||.||..|.|||.  .  .||       |||.|. .. |.||. |. ...
DatrvkvtpneenkntDYinanfvpgy.kgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagk..lkChrYWPddn.selkygdvtvkstae

RTTDYHVERIIHLtHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtqIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIADIPQ
...  ..|| ..| .  . . |....|..||||. |||...  ||.| .||........|  .|.|.|||||. |||..  . ........ .  .|. .
eekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk..aplvihCsaGvGrtGtyialDrlvkaveaeleeldvka

VVKKLRLQRRWMISEKEQLKFSYDAILCYAR
||..|| .| .|.    | .| | |.| .  
vvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 77-305 9.6e-53 174.0 In-house 41-271 (274) alignment 
Range on Protein: 77-305
Range on HMM: 41-271/274.0
DHNRVCLRG-----TRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDKGA--AQKFGDISVSL
.. ||.|.         .|||| .||    .| ...||| ||.  ..|||.|.|......||||     . .  .  . |.|.....  ....||...  
ensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk..lkeaneqkCavyfPdaedyeiserygdveikv

QSK-RTTDYHVERiIHLTHLPTrqMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIA
... .. ||.|.. . | .|     |...|  .|.||.  .| ..  ||....||.. .... .   |.|||||||| |||.|  .  | |...| . . 
ekiverndysvrk.lvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreei.vv

DIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHA
|. ..| .|||.|  |. ..|| .. . |.  |... 
dvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 77-301 4.9e-52 171.8 In-house 60-278 (288) alignment 
Range on Protein: 77-301
Range on HMM: 60-278/288.0
DHNRVCLRG----TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDkGAAQKFGDISVSLQSK
|..|| |..    .  ||||||.|..    .  .||||.||. ..|||| .|||...| |||| .     .| |.   |||.. .  ...|.. | |...
DekrvklkkleeeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyenktstivmlte..lveggktkCeeYWPda.dkpknyGsvtvtlves

RTTDYHVERIIHLThlPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrktQIPIVVHCSAGIDRTGVFCLVYTAAREIKEgHGIADIPQ
.... .|.| . |    . . ..||..|..|||. ||| |   ||.... |.  ....   . ||.||||||. |||.|  . ..  ...| .   |.  
keledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidavee.edyiDvag

VVKKLRLQRRWMISEKEQLKFSYDAILCY
.|.||| ||  .. ...|  | |...|  
tvaklRkqRallvqtlkqYefiyevllsl
subfamily_PTPN6_pd Subfamily PTPN6 77-304 5.4e-52 171.7 In-house 67-299 (306) alignment 
Range on Protein: 77-304
Range on HMM: 67-299/306.0
DHNRVCL--RGT-RDDYINASFIKDVVPTS-PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVSYWPEDKGAAQkFGDISVSLQSK
||.|| |   ..  .|||||..||. |..|  ..||||  |.  ..||| ||..... .|||.  .  . .|    . |||. .   . .|.|||.  |.
DhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttke..vErgkekCarYWPdeeekee.yGkisvtnvse

RTTDYHVERIIHLTH-LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQR-KTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEG--HGIA
..... . | .....    .. |.. ...|..||. |||..||..|.|...|.. ... . ... |||||||||| ||| | .. .  . |..   .   
ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadi

DIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
|| ..||..| ||  ..  ..| || | ||  | ..
diqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 77-303 8.8e-52 171.1 In-house 61-284 (319) alignment 
Range on Protein: 77-303
Range on HMM: 61-284/319.0
DHNRVCLRGTR----DDYINASFIKDvVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVSYWPEDKgaAQKFGDISVSLQSK
|. || |         ||||||||         ||||||||.  ..||| ||.|...||.|||     . |.  ..  |||| .   ...| . | |...
drtrvvlseldgvegsdyinasfidg.yqerekfiatqaPlentiedfWrmvWeeessivvmltkl..veklkvklkkywpeen..feeyGrlivtleee

RTTDYHVERIIHLtHLPTRQM--RTITHLQFTAWPEFGVPSSPGVLLQFIDEVQsyHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEgHGIADI
. ..  . | ..| .  . ..  |...| |.|.||. .|| .   ||... ...  .|...... |||||||||. ||| |. .  .   .||  |. |.
eeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrir..ksrektqsgPivvhCsaGvGRtGtfivldamlervke.egvlDv

PQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
 ..|..||.||  |....|| || |.|.| .. 
fstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 77-302 1.6e-50 166.6 In-house 22-242 (250) alignment 
Range on Protein: 77-302
Range on HMM: 22-242/250.0
DHNRVCLRGTR----DDYINASFIKDVVPTsPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKGstnFVSYWPEDKgaAQKFGDISVSLQSK
|. || |  ..     |||||||..    .   |||||.|||....||| ||.|.... |||| .   ..|    .  ||| .|  |.|.||. ||| ||
dssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt...yhqywPvek..aekyGdvtvsllsk

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyhSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQ
 .    . | . |..    . |.. .|.|..||. |||      |.....||.  |||.  . |..|.||||. |.| |. ...    .|. . . |. .
eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqa..sqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvv.dvfk

VVKKLRLQRRWMISEKEQLKFSYDAILCYA
|.|.|| .|  ..  .||  | | .|| . 
vikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPN14_pd Subfamily PTPN14 77-303 2.2e-50 166.4 In-house 62-297 (300) alignment 
Range on Protein: 77-303
Range on HMM: 62-297/300.0
DHNRVCLRGT---RDDYINASFIKDVVPTS-PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPED--KGAAQKFGDISVSLQ
..||| |  |   ...||||| || .| ..   .|..|.||.  ..||| ||.||. ..|||| ..   ||  .  ..|.|..  |    .||   |. .
ednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk..eksfkyfPkleskkktvefgkfkvttk

SKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRK------TQIPIVVHCSAGIDRTGVFCLVYTAAREIKEG
 ....|  . . ..| |||... ||. |||.| ||. |||. .   |....||||   .  .      .. |..||||||. ||||  |.      .. .
fsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn

HGIaDIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
. | ||..|...|| ||  ...   | || |.... | .
eei.dikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN13_pd Subfamily PTPN13 77-300 3e-50 166.0 In-house 50-267 (273) alignment 
Range on Protein: 77-300
Range on HMM: 50-267/273.0
DHNRVCLRGTRDdYINASFIKDVVPTS-PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFGD-ISVSLQSKRT
|. || | .    |||||.||  |      .||.| ||  . .|||.||.||.|..|.|. ..  .||       |||| |.   |  . . |.|     
detrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk..vkchrywPesknkklkvsnrlevellkvqk

TDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrkTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQVV
 |  | | ...... ... | ..||.|..||. |||||.  ||||. ||.. ..     . |||||||||| |.|..  ....   |.  . . |. ..|
ldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....dagPivvhcsaGiGrsGtlitidvvlglierdkef.dvkeiv

KKLRLQRRWMISEKEQLKFSYDAILC
.||| ||. ..  |.|  | | ||| 
rklreqrqgvvqtkdqyifvykaile
subfamily_PTPRA_pd Subfamily PTPRA 77-301 1.8e-49 163.4 In-house 71-294 (330) alignment 
Range on Protein: 77-301
Range on HMM: 71-294/330.0
DHNRVCLR---GT-RDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDkGaAQKFGDISVSLQSK
|..|| |    |.   ||||||||.        |||.| |.. ...||| |..||... ||||       .  .    |||.. | .  .|.| |... .
dfsrvilsvkeGveesdyinasfidGy.kekdkfiaaqGPkeetvedfwrmiweqksativmlte..lkerkeekcaqywPde.G.lvtyGnirvevede

R-TTDYHVERIIhLTHLPT----RQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYhsQQRKTQiPIVVHCSAGIDRTGVFCLVYTAAREIKeGHGI
  . || |  .. ...||     .. | .. . ||.||..|||. |  .|... .|..   .|.... |||||||||. ||| |. . .    .|   ..
tvlvdytvrkfl.vqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl..nqqsag.pivvhcsaGvGrtGtfivldavlervk.aerk

ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
 |. ..||.|||||  |.  .|| .| | ..| |
vdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRK_pd Subfamily PTPRK 77-299 3.3e-49 162.4 In-house 56-274 (314) alignment 
Range on Protein: 77-299
Range on HMM: 56-274/314.0
DHNRVCLRGTRDD----YINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVSYWPEDkgaAQKFGDISVSLQSK
|. || |  . .|    ||||..| |    .  ||.|| |||  ..||| .||..... ||||     . .|  . . |||||   ....||| | | . 
drsrvflitidgdpssdyinaali.dsykrpaafivtqgPlqetvkdfWrlvydencasivmltel..vevgrvkClkyWPed...tevygdikvelvet

RTTDYHVERIIHLTH--LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQqrkTQIPIVVHCSAGIDRTGVFCLVYTAArEIKEGHGIADI
 .    | ||  ...   .  ..|.. ..||..||...|| |   ||... .|.. . .   .. .||||||||  |||.|. . .   .. | .|. |.
ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivl.dmieregvvdv

PQVVKKLRLQRRWMISEKEQLKFSYDAIL
 ..||.|| ..  |.  .|| || ||.||
fnavktlrsrkvnmveteeqykfiydvil
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 77-301 3.5e-49 162.4 In-house 57-276 (315) alignment 
Range on Protein: 77-301
Range on HMM: 57-276/315.0
DHNRVCL----RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKGSTnfVSYWPEDKGAAQKFGDISVSLQSK
|..|| |        .||||||.|| |  .  ..||.|.||. |..||| ||...... |||.  |    | .     |||. |. . .|| |.|.| | 
dsarvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikc..rqywPdrkadsvefGsikvellsl

RTTDYHVERIIhlTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQ
 ..   | | .  .   . . ||.|  ||| ||. ||.   . ||..| ||.. .    | . ...||||||. ||||.. .     .||... . |. .
eadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadng...kkefsllvhcsaGvGrtGvvisidevvaqikrtrsv.dvfn

VVKKLRLQRRWMISEKEQLKFSYDAILCY
.||.|| .|  ..  .|.  | |||.| .
fvknlrakrpylvqteeeyafiydavled
subfamily_PTPN12_pd Subfamily PTPN12 77-307 1.1e-48 160.6 In-house 53-282 (290) alignment 
Range on Protein: 77-307
Range on HMM: 53-282/290.0
DHNRVCLRGT----RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFGDISVSLQSK
|..|| |. .     .|||||.||| |   .  .||.|.||   |.||| |..|.. .|.||.  .   ||  .    |||| .. . .||...|.|...
dksrvelskieeeegsdYinanfikgve.gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk..kkCerYWpeegeeelefgefevtleee

RTTD-YHVERIIHLTHLptRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHG--IAD
...|  .. | .....   .. |... ...||||. |||||.  ||..|..|.....   . ..|.|||||||. |||. . .  . . .|...     |
kavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeld

IPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHALA
. ..| .|| ||  ..  ||| .. | |.. . .. |.
vfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 77-301 1.9e-48 160.1 In-house 64-283 (297) alignment 
Range on Protein: 77-301
Range on HMM: 64-283/297.0
DHNRVCLRGTRDD----YINASFIKDVVPtspCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgstNFVSYWPEDkGAAQkFGDISVSLQSK
| .|| |. . ||    |.||||.| .      .|.|| | . ...||| ||...|.|.||||  .  . |   .   ||... | .. |||.|| |.| 
dssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk...kcaryWsdk.gvtt.fGdvsvvllsv

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPS--SPGVLLQFIDEVQSYHSQQRKTqiPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDI
      ..| ...|.  ... | .   ||. ||.  |.   |   ||..|.||.  .||. ..  |..|||.||. ||||.. .     |.|. . . ||
sereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg..PllvhclaGvGrtgvlltidsvvaeakrekev.di

PQVVKKLRLQRRWMISEKEQLKFSYDAILCY
 ..||||| .|  ..  ||| || | |.| .
fglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Ptp69D_pd Subfamily Ptp69D 77-305 8.5e-48 158.0 In-house 61-289 (307) alignment 
Range on Protein: 77-305
Range on HMM: 61-289/307.0
DHNRVCLRGT----RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDkgAAQKFGDISVSLQSK
|..|| |. .      |||||||||     .  ||| |.|..  ..||| |. ||.  .||||     | |   .   |||..    ...||| | | |.
DktRvkLkkingkedsdYinasfikgyk.ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsn..lteknrkkcakYWpie..devqygdilvklvse

RTTDYHVERIIHLTHLP-----TRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrktQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgI
........| .....         . | ..  ..|.|... || ..  ||..|..|.. ....   . ||||||||| .|.|.|  .     ..|. .  
ekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllqqlkaed.k

ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHA
.|| ..||.|| ||  ..   || .| | |.| |  ..
vdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 77-302 4.3e-46 152.5 In-house 61-288 (325) alignment 
Range on Protein: 77-302
Range on HMM: 61-288/325.0
DHNRVCLRGTRD----DYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpAtgKGSTNFVSYWPEDKGAAQKFGDISVSLQSK
|..||.|   .|    ||||||...| .     |.|.||||  ..||.| .|.. ..|..|.|       .|  .   |||.. | ...|| . |.|.. 
dksrvvletkkddpssdyinasylrddk.kkdvflaaqaPltatindlWrlvldWrcsvvvvlnel.d..lgkdrcavywpkemgksktfGglevklrti

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQR---KTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIAD
 .   .| |....      . |..  .|. .|...||.  |  |. ... |.  . . .   |.  ||.||||||. |||||  .|.|. .. |     |
eeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakviees.rvd

IPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
| ..||||| .|  |.   .|  . |.|.  . 
ifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPRN_pd Subfamily PTPRN 77-299 2.7e-44 146.1 In-house 69-289 (297) alignment 
Range on Protein: 77-299
Range on HMM: 69-289/297.0
DHNRVCLRG----TRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVSYWPEDKGAAQKFGDISVSLQSK
||.|| |.     ...||||||.| |  | .|..||||.||  .. ||| ||.|| . .||.| .   . .| ..   |||..  .  .. .. .  .  
dhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrl..eeegvkqckrywpdeGsevyhiyevhlvsehi

RTTDYHVeRIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIADIPQ
 . || | | ..|  | |.. ||.| . | .||| |||.|.  ||.|   |.  .   |    |||||||.|  ||||..|.      .. |    ||  
wcddylv.rsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksy...rGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaa

VVKKLRLQRRWMISEKEQLKFSYDAIL
 ...|| ||  ..  |.|..| . |. 
tlehlrdqrpglvktkdqfefaltava
subfamily_PTPRG_pd Subfamily PTPRG 77-299 3e-44 146.2 In-house 60-284 (563) alignment 
Range on Protein: 77-299
Range on HMM: 60-284/563.0
DHNRVCLRGTRD-----DYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVSYWPEdkGAAQKFGDISVSLQS
|. || |... .     |||||..|.     |  ||||| ||.  ..||| |..||...||||.     . .|  .   |||.    ....| ..| |..
drsRvklsplpgkkkklDYinAnyidGy.qkskafiatqgplkdtfddFWrmiWeqnvaiivmitnl..vergrrkcdvYWPk..desetygalqvtlie

KRTTDYHVERIIHLTHLPTR--Q----MRTITHLQFTAWPEFGVPSSPGVLLQFIDEVqsyHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEgH
. .. .  .| . . .|  .  .     ..... ..| ||. |||...   |.|.         ....  |||||||||. |||... . |  ..|.. .
eevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks...saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq.e

GIADIPQVVKKLRLQRRWMISEKEQLKFSYDAIL
 . .. ...|..|.||  .. ..||  | .||.|
navnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 77-300 1.9e-42 140.7 In-house 74-289 (319) alignment 
Range on Protein: 77-300
Range on HMM: 74-289/319.0
DHNRVCLRGT----RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLskpatgkgSTNFVSYWPEDKGAAQKFGDISVSLqsK
|.|.| |. .      |||||||..        .||.| ||. .|.||| |..|...| ||.|               ||| .    .. ....|..   
dknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt........kdkcsqywplkivikeerfkvkvds..v

RTTDYHVERIIHLTH-LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIP
  |. .| | |.|..    ...| ||   |  ||. ||| .|  |..... |.  .|.. . . .||||||||. ||||.  . .    .|| . . |. 
eetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske.nhranivvhcsaGvGrtGvyivldvlldrmkeekqv.dvy

QVVKKLRLQRRWMISEKEQLKFSYDAILC
..|. || ||  .. .  | || | |.| 
nfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 77-300 3.6e-42 139.8 In-house 38-253 (284) alignment 
Range on Protein: 77-300
Range on HMM: 38-253/284.0
DHNRVCLRGT----RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLskpatgkgSTNFVSYWPEDKGAAQKFGDISVSLqsK
|.|.| |. .      ||||||||.        .|||| ||. .|.||| |..|...| ||.|           .   ||| .    .. ....|..   
dknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt........kdkcsqywplkivikeerfkvkvds..v

RTTDYHVERIIHLTH-LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIADIP
  .. .| | |.|..    ...|.|.   |  ||. ||| .|  |..... |.  .|.. . . .||||||||. ||||.  . .    .|| .   |. 
eeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske.nhranivvhcsagvgrtgvyivldvlldrmkeek.qvdvy

QVVKKLRLQRRWMISEKEQLKFSYDAILC
..|..|| ||  .. .  | || | |.| 
nfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 77-299 4.3e-39 129.3 In-house 62-276 (315) alignment 
Range on Protein: 77-299
Range on HMM: 62-276/315.0
DHNRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDkgaAQKFGDISVSLQSK
|. || |         ||.||.||.        .||.|.|.  |..||| .|.|.. . |||| .     |   .   |||..      .| |.|...|.
dksrvqlpllendphsdyvnanfidGy.nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegek..rkaekywpdk...kviyGkitvtrkse

RTTDYHVERIIhlTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRktqIPIVVHCSAGIDRTGVFCLVyTAAREIKEGHGIADIPQ
   .    | .  .     ..|..  |..|.||. ||| .   |...|  |. .| ..     .||||||||. ||| |. .  |  .  |   . |. .
evnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitl.davldqaeaenaidvyn

VVKKLRLQRRWMISEKEQLKFSYDAIL
.....| .|. |..  || .| |||.|
fitgvrqnrikmvqvaeqyqfiydall
subfamily_CG7180_pd Subfamily CG7180 77-301 1.1e-37 124.3 In-house 55-289 (296) alignment 
Range on Protein: 77-301
Range on HMM: 55-289/296.0
DHNRVCLR---G-TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgstNFVSYWPEDKgaAQKFGDISVSLQSK
|.||| |.   |  ..|||||...   .     .| |.|| . ....|| .||....| .|.|  ..   |    . ||||..    ...|.| | . ..
DynRvvLekldGeeksdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak...mypsywpnks..keqygeifveivee

RTTDYHVERIIHLTHL----------PTRQMRTITHLQFTAWPE-FGVPSSPGVLLQFIDEVQSYHSQQ--RKTQIPIVVHCSAGIDRTGVFCLVyTAAR
..    . | ..||.            . . |.....|.| |.    ||.|   |....  |...  .   .... |.||..| |  |.||.. .  |. 
kqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylai.danl

EIKEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
|  | ..  |. . ||.|| .|. .. ..|. |. || .| .
elvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 77-303 1e-34 114.7 In-house 51-278 (287) alignment 
Range on Protein: 77-303
Range on HMM: 51-278/287.0
DHNRVCLRGTR---DDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVSYWPEDkGAAQKFGDISVSLQS--
|..|| |  .     ||||| ..         |||.|.|.  ...||| .|.|.... ....  .    ..  .   ||||      . |  || | .  
ddtrvllsaegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtre..veearlkcykywPer.evPmrvGGysvvlldyd

KRTTDYHVeRIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKTQ--IPIVVHCSAGIDRTGVFCLVYTAAReIKEGHGIAD
..  .| | | . | .| ||. | .  |.. .||. ... .   |..|. .|. .   .|...   |.|||...|| |.|..  ...  .   |  |  |
ikePeygv.ralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs.rledlGrvd

IPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
. .|| .|| .|. ..    ||...|.|.  | .
vaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 77-299 7.8e-31 102.0 In-house 61-276 (439) alignment 
Range on Protein: 77-299
Range on HMM: 61-276/439.0
DHNRVCLRG----TRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgstnfvsYWPEDKGAaqKFGDISVSLQSK
|| || |.         |||| .||    .   .||||.| . . .||| .|.|.... ||||     . |       ||| |. .   .|||.|  . .
dhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.......ywpsdaev..cygdiavrvdrn

RTTDYHVERIIHL--THLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHsqQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIADI
     .| | ...   .  |.. ||. .....|||.  ||.    .|.|.  ..|    ...   |.|||||||. |||    .  |  ..|      ||
ielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan..dkeeygpvvvhcsagvGrtGtiialdialeqlklen.kvdi

PQVVKKLRLQRRWMISEKEQLKFSYDAIL
  .|| || ||. |. .  |  | |.|.|
kgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 77-306 1.9e-29 97.5 In-house 46-263 (267) alignment 
Range on Protein: 77-306
Range on HMM: 46-263/267.0
DHNRVCLRGTRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpatgKGSTNFVSYWPEDKGAAQKFGDISVSLQ-SKRTT
|..|| || . ..|||||.. .   |   ||.|| ||. .  ||. .. .|. ..||.|        .  |   .||   | |.|. |..|     |   
ddtrvilrtkeeeyinasyv.egyktknafivtqdplkntitdfltvihdqkvpvivlltk.....vftdnirlfwPPkmgqakkyqdltvehslekeen

DYHVerIIHLTHLPTRQMRTITHLQFTAWpEFGVPSSPgvLLQFIDEVQSyHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEgHGIADIPQVVK
||..  |    ..     . .|   .  | .  .   |   |. .  . . . |  . . |.||.||.|. |.| |  ...  . .|.  |..|| . ..
dyqi..itlelkfknesahnvtlyyykkw.nintnnkp..ylkplfgila.knqlengnrPlvvacsdGvGrsGtflvidsqlerakt.egvsdifdflr

KLRLQRRWMISEKEQLKFSYDAILCYARHAL
|.| ||  ..  ||.  . .. .  ||.  |
kirsqriglvdtkeryiyihellaeyaegrl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 77-302 5e-29 95.9 In-house 68-289 (305) alignment 
Range on Protein: 77-302
Range on HMM: 68-289/305.0
DHNRVCL-RGTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKF--GDISVSLQSKR
|.. | | . .  ||| | ..   .     ||..| ||. ....|| || ...   ||||     .||   .   |||  .|  ...  | .   .   .
dqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgk..lkcaqywpaaqgeklelksgivvenvsgsk

TTDYHVERIIHLTHLP--TRQMRTITHLQFTAWPEFGVPSSPGVLLQFIdevqsyhSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIADIP
  .   |  | | .|     |  .. |||.| ||. |||      |...       |  | ...|||||||||| |||    .     .| | .    .|
pmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslell.......sairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmp

QVVKKLRLQRRWMISEKEQLKFSYDAILCYA
..|| || || . | .  |  | .  .| | 
elvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 77-301 3.3e-28 93.6 In-house 54-276 (307) alignment 
Range on Protein: 77-301
Range on HMM: 54-276/307.0
DHNRVCL--RGTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFGDI----SVS-L
|..|. .   |   ||| | ..   .     ||..| ||. .  .|| |. ...   ..||     ..|   .   ||| ..|  . ||.     ||. |
dkgrivvkfdglasdyihanylgiai.kpkkficaqgplentqysfwamaiqekvesvimlckvielak..ikceqywpleegqklvfgeapntisvanl

QS-KRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPgvlLQFIDEVQSYhsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIA
 . | . | ..  .  |    ... |||.|||.. ||. |||      |  |. ...     |  . |.|||||||. |.|    .      . .|    
gakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin...ltainlleav....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinck

DIPQVVKKLRLQRRWMISEKEQLKFSYDAILCY
|. ..|..|| ||.. | .. |  . .  .| |
dmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 77-299 3.6e-28 93.3 In-house 21-238 (239) alignment 
Range on Protein: 77-299
Range on HMM: 21-238/239.0
DHNRVCLRG----TRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEdkgAAQKFGDISVSLQSK
||.|| |       . ||||||...|   .  ..||||  ...|  ||| |.....  .||||       |   .   |||.   .. |. .. |.|.  
dhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk..kkchqywpd...stskycnlrvtlrkt

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyhsQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIADIPQ
     .. | . ....   . | . . .|| ||. |||     .| .  ..     .      | |.|||||. ||| | .. .  |. |. .   || .
evfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk...dslpgarpwvihcsagvgrtgaflvidamlrqakkqk.tvdifn

VVKKLRLQRRWMISEKEQLKFSYDAIL
 || .| .|  |.   ||  | . |.|
yvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 77-299 3.6e-28 93.3 In-house 20-237 (239) alignment 
Range on Protein: 77-299
Range on HMM: 20-237/239.0
DHNRVCLRG----TRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEdkgAAQKFGDISVSLQSK
||.|| |       . ||||||...|   .  ..||||  ...|  ||| |.....  .||||       |   .   |||.   .. |. .. |.|.  
dhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk..kkchqywpd...stskycnlrvtlrkt

RTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyhsQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIADIPQ
     .. | . ....   . | . . .|| ||. |||     .| .  ..     .      | |.|||||. ||| | .. .  |. |. .   || .
evfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk...dslpgarpwvihcsagvgrtgaflvidamlrqakkqk.tvdifn

VVKKLRLQRRWMISEKEQLKFSYDAIL
 || .| .|  |.   ||  | . |.|
yvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 77-301 9.5e-23 75.6 In-house 56-270 (288) alignment 
Range on Protein: 77-301
Range on HMM: 56-270/288.0
DHNRVCLRGTRDDYINASFIKdVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDKGAAQKFGDISVSLQSKRttd
|  || |    | ||.|  .    .    .| .||||.  .. .| |. |..   ||||       ||  .   |.|  .| . ..| .    . ||   
ditrvklsddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlce..llekGkeksaeyfPsklGekarigrlctvvkkkr...

YHVERIIHLTHLPTRQM----RTITHLQFTAWPEFGVPSSPGVLLQFIDEVqsyhsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIADIPQ
  ........ |   .       . .| .  |.. ||| .    |.... .       ...| |||||.|||. ||| . |.  |.. ..       |..
adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlililialeslrldd.flgirs

VVKKLRLQRRWMISEKEQLKFSYDAILCY
...||| .|.  |  . |  . .  .| .
llaklreerfkaiqtemqylyvhrcvlee
0044763 (Phosphotyrosine protein) phosphatases II 77-293 1.2e-22 75.9 In-house 3-162 (178) alignment 
Range on Protein: 77-293
Range on HMM: 3-162/178.0
DHNRVCLRGTRD----DYINASFIKdvvptsPCFIATQAPLqpslNDFWLMVYEQQASIIVMLLSKPATGkgSTNFVSYWPEDKGaaqkfgdisvslqsk
|..||.|   ..    ||||||.|       | ......|      |.. ...|.  . ||.| .    |    .   ||||. |               
drtrvllsnleglersdyinaseil......pglylgslpp....addlellkelgithivnlteelelg..flkcdpywpeeag...............

rttdyhveriihlthlptrqmrtITHLQFtAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtqiPIVVHCSAGIDRTGVFCLVYTAAREikeghGIaDIPQ
                       |..|..  .| .|||...  .|.|.. ........ .   |..||||||..|.|.... |   .      |. ....
.......................iqylhi.pipDhgvpdllehflefvefieealdekgg...pvlVHCsaGvgRsgtlvaaylmkkl.....gl.slee

VVKKLRLQRRwMISEKEQLKF
... .| .|. ..   .||..
aielvrerRp.ivpnpgqlrq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 77-256 2.9e-16 54.0 In-house 56-231 (312) alignment 
Range on Protein: 77-256
Range on HMM: 56-231/312.0
DHNRVCLRGTRDDYINASFIKdvVPTSPC-FIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKG-----STNFVSYW-PED-KGAAQKFGDISVS
|  |  | |  . || | |.|  . | |  |..||.||. .   || ..    .. |..| .    |        .. |..   || .  ..   .| . 
drgrftlagdenfyihanfvk..ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieig

LQSKrttDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIdevqsyhSQQRKTQIPIVVHCSAGIDRTGVFCLVYT
 .||   |    |....    | |   . | |...||. |.| |    |...       |  .| . |.. |||||. ||| ..|. .
gksk...dkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll.......savkkdkkpviahcsagvgrtgtlalies
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 77-306 5.3e-14 46.5 In-house 60-280 (303) alignment 
Range on Protein: 77-306
Range on HMM: 60-280/303.0
DHNRVCLrgTRDDYINASFIKdvVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKGSTNFVsyWPEDKGaAQKFGDISVSLQSKRTTD
|| .| |  .   || ||...  . .|   | || ||. .  ||| |. ||.   ...||.     |   ..|  .|...    || . |. .   .  .
dhskvkl..sdssyihasyle..ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv..fprnqd.flkfeersirvgefkrve

YHVERIIHLTHLPTRQMRTITHLQ-FTAWPEFGVPSS-PGVLLQFIDEVQSYHSQQRKTQiPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIADIPQVV
      ...  .   . ... |.. . |||   .||     ... | ..||.  .  ... | |    .|  |.| |.|  ||   ...     |. ...
lgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfalfetahlslhseqasldlvkcl

KKLRLQRRWMISEKEQLKFSYDAIlcyARHAL
...|  |   . .  |. . |  .   | | |
envrngrlhavqnlsqfsvvytll...aehvl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 77-172 1.9e-07 25.0 In-house 109-198 (244) alignment 
Range on Protein: 77-172
Range on HMM: 109-198/244.0
DHNRVCLR-G-TRDDYINASFIKDVVPTSpCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpatgkgsTNFVSYWPEDKGAAQKFGDISVSLQSK
| ||| |  |   . ||||||.  .  |.  .| || ||  .  ||| |. |.   ..|.| |         .   |||. .       ||.|.|  .
dfnrvplskgsmgntyinasfvgclgrta.eyiltqhpladtsmdfwkmmlerhvnvlvvlgsv.......eeedeywpdseplewyeeditvtltdr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 78-301 9.4e-49 160.8 In-house 57-275 (515) alignment 
Range on Protein: 78-301
Range on HMM: 57-275/515.0
HNRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFGDISVSLQSKR
 .|| |         ||.|||.|. .  .  ..||.|.|.. |..||| .|.... . |.|.  .    |   .   |||.  | . ||| |.|.| |  
svrvklevindnPhsdyfnasyipsf.dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdk..ikcgkyWPdkpgdsvkfGsikvelvsle

TTDYHVERIIHLTHlpTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRktqIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQV
.    . | .....    ..||.|  .|| ||. |||     ||..| ||.. |.|      |...|||||. ||||.. .     ..|... . |. ..
actggikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt...hpliihcsaGvGrtGvvisidsvvahakttrmv.dvfnf

VKKLRLQRRWMISEKEQLKFSYDAILCY
|...| .|  ..  .||  | |.|.| .
vtnirqkrpylvqtqeqyafiygavled
0041856 (Phosphotyrosine protein) phosphatases II 78-303 4.9e-34 112.9 In-house 15-172 (182) alignment 
Range on Protein: 78-303
Range on HMM: 15-172/182.0
HNRvclrgtRDDYINASFIKDVVPTSPcFIATQAPLQPSLNDFWLMVYEQQASIIVMLLskpatgkgstnFVSYWPedkgaaqkfgdisvslqskrttdy
|.|        |||||...    |..  |||||.||. ...||. |..|.. ..||.|             . |||                        
hsr......dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt...........eelywp........................

hveriihlthlpTRQMRTITHLQFTAWPEFGVPSsPGVLLQFIDEVQSyhsqqrkTQIPIVVHCSAGIDRTGVFCLVYTAAREikeghGiADIPQVVKKL
            .. .|........ || .|||. .  ||.||.||..        . |..||||||..|||.... |   .      |  .....|| .
............ellerlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl.....g.vsleeavklv

RLQRRWMISEKEQLKFSYDAILCYAR
| .|  |.   .|. | ..|.|.. .
rsrRpgmvitpnqyfflqlallelll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 78-299 1.3e-31 104.4 In-house 59-233 (392) alignment 
Range on Protein: 78-299
Range on HMM: 59-233/392.0
HNRVCL----RGTRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLsKPATGKgstnfvsywpedkgaaqkfgdisvslqskr
 .|| |      . .||.|||.|. .  .  ..||.|.|   ||.||| ||...... |.|.  |   |                               
sarvkleviddipdsdylnasyipsf.dnekayiasqgpnaaslddfwrmvfqenvttiamvt.klkegd..............................

ttdyhveriihlthlPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtqiPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIADIPQV
                  ..||..  .|| ||. .||     ||.|| ||.. . |  .   |...|||||. ||||   . .     |. . . |. ..
...............kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth...pliihcsagvgrtgvvisidsvvahakktr.mvdvfnf

VKKLRLQRRWMISEKEQLKFSYDAIL
| ..| .| .|.  |||  | | |.|
vtnirrkrpymvqtkeqyafiygavl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 78-301 7.8e-22 72.6 In-house 49-269 (285) alignment 
Range on Protein: 78-301
Range on HMM: 49-269/285.0
HNRVCLRGTRDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSYWPEDKGAAQKFGDISVSLQSKRTTDY
  || |.    ||| ||...        .|.|| ||  .|.||| |.|... . ..|| .      |  .   |.||  |   |||   ..|   .    
etrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeg..gvekcalyypeklgevvkfgkyeitlteckeeai

HVERIIHLTHLPTR----QMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYhsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQV
    .  || . |     .   . |.|   ||.   |     ....   |.         . ||.||||||. ||  |  .  |.  | |   | .. ..
agtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv....npkekpicvhcsagvgrtatfvgidyatirimenpni.emldi

VKKLRLQRRWMISEKEQLKFSYDAILCY
|...|  |   .  . |. | |  .. |
vremramrfqavqshmqflflyvvlmey
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 79-301 4.5e-55 181.9 In-house 61-279 (318) alignment 
Range on Protein: 79-301
Range on HMM: 61-279/318.0
NRVCLRG----TRDDYINASFIKDVvPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKgaAQKFGDISVSLQSKRT
 || |.     .  |||||..|      .  .||.||||   ..||| ||.||....||||  .   ||  .    |||...  ....|.. | |... .
trvkLqmlegeegsDyinanyidGy.rrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergk..akvhryWPskg..srsygklvvelkeeve

TDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYhsQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEgHGIADIPQVV
....| | ...|.  . . |..   ..|.||. |||.|.. ||... .|...  ||.... |||||||||. |||||. | .  . ||.  .. |. |.|
lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska..qqksgagpivvhCsaGvGrtGvfiavdillerika.ealvDvfqtv

KKLRLQRRWMISEKEQLKFSYDAILCY
|.|| ||  |.  ..| .| ||..| .
kqlreqrnlmvqtedqyefiydvllea
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 79-306 7.8e-44 144.7 In-house 35-268 (270) alignment 
Range on Protein: 79-306
Range on HMM: 35-268/270.0
NRVCLRGTRD----DYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLlsKPATGKGSTNFVSYWPEDKGA--AQKFGDISVSLQSK
 ||.|   ..     |||| ... .   .  .||...||. .|..|| |..|.... |||.   . . || ..   |||....   . ..|.|.|  .|.
tRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmt..tgleEkgrkkCerYWpaepkekvkledgkikvlalse

RTTDYHVERIIHLThlPTRQMRTITHLQFTAWPEFGVPSSPG------VLLQFIDEVQSYHSQQRKTQiPIVVHCSAGIDRTGVFCLVYTAAREIKEGhG
. .. .. . ..|.   . . | ..| ....||. |||....       ||. . .|. ......|.. |..||||||..|||.. .. .| | ..|  .
ekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeet.k

IADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHAL
 .|. .....|| .|  ...  || .| | |.. ||....
kvdvlaiieelRkdRmalvqhpeqyeflykavveyaerra
0049772 (Phosphotyrosine protein) phosphatases II 79-302 3.8e-27 91.3 In-house 60-280 (314) alignment 
Range on Protein: 79-302
Range on HMM: 60-280/314.0
NRVCLRG---TRDDYINASFIKDVvptsPCFIATQAPLQPSLNDF----------WLMV--YEQQASIIVM---------------------LLSKPATG
|||.| |      ||||||... .      |||||.||.  ..||          | ||  ....  .|||                     ||. .  |
nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng

kgstnfvSYWPEDKGAAQKfgdisvslqskrttdyhveriiHLTHLPTRQMRT-ITHLQFtAWPEFGVPsSPGVLLQFIDEVQSYhsqqrKTQIPIVVHC
       .....   .  |                        .. | .  |. |..|..  .| ...| ..  ...|.. ....     ... |..|||
.......neptaadlellk......................eelydpelferlgikylri.pvpDgsap.lledfdeflefieea.....dkggpvlvHC

SAGIDRTGVFCLVYTAAREIkeghGIaDIPQVVKKLRLQRR-----WMISEKEQLKFSYDAILCYA
.||..|||.|....   .      |. .. .... .||.|       .|   ||. | ..|.| | 
kaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_ptpA1_pd Subfamily ptpA1 79-255 4.3e-23 76.7 In-house 62-250 (418) alignment 
Range on Protein: 79-255
Range on HMM: 62-250/418.0
NRVCLRGTR----DDYINASFIKDVVPTSpcFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGAAQ---------KFGDI
 || |.  .     ||||| .|    |    ||.|| ||  .. ||| ||.|... |||||  .    .   .   ||||. |  |          ||  
trvqlkkiqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmvwenrcriivmlsrese..ncrikcdrywpeqiggeqfsiygngnevfgty

SVSLQSKrTTDYH---VERIIHLTHlpTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHS---QQRKTQIPIVVHCSAGIDRTGVFCLVY
|| |      |     . | |.||     . | ||. |.  ||.. .|     . |..  .   .         ..||.||||||. ||| ||   
svelvev.iqdpereiitrnirltf..egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 85-302 3.6e-37 122.7 In-house 67-293 (301) alignment 
Range on Protein: 85-302
Range on HMM: 67-293/301.0
GTRDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKGStnFVSYWPEDKGAAQKFGDISVSLQSKRT-TDYHV----
 .. .|||||.|...   .  |||.|.|..  | ||| ...... . |||.  .  . | .     |||. .   ..|| ..| |... .  |. .    
lcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtksk..ceqywpnseaeseefgpftvtlvneqvyPdfvirqln

------------ERIIHLThlPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVqsYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKeGHGI
            || .. .   ... .... || | ||. ||   |   || ||.|   | ||.    |.|||||... |.||.| |  .    |   |.
vkiqdgsnngyierkfkvk..sdksswdvlqlqvtdWpqdGvvreprtvLqviddv..ihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQck.aegV

ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYA
 |. ||.| .| ..  ..   ||  . ||.|  | 
VdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 85-303 3.2e-20 66.9 In-house 76-291 (310) alignment 
Range on Protein: 85-303
Range on HMM: 76-291/310.0
GTRDDYINASFIKDVVPTSpCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEdKGAAQKFGDISVSLQSKRTTDYHVERIiH
   .||| | ..|     |  || .| ||| .. ||| |.....|  |..|    .. .|  . |.|||   | .. .| | |.  |. . .. .  .  
sryedyihanyvktnylrs.tficsqgplqhtiidfwrmifqeraesilllck..vgeegrpkcvgywps.lgvtetygcirvtnlsesseefeicnl.a

LTHLPTR-----QMR-----TITHLQFTAWPEFGVPSSPGVLLqfideVQSYHSQQRKTqiPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQVV
.| .|       |        .. ...  ||. |||      .      |   .| |.   | |||||||.||..| . .  .   ...|. . |. .|.
vtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv.....pqrllaqvrhg..pcvvhcsagkdrlyvvvalklkidkldrglkv.daeevk

KKLRLQRRWMISEKEQLKFSYDAILCYAR
 .|. .|   |  . |  .     . .||
tellksraiciqtelqyliidrvriifar
subfamily_eak_pd Subfamily eak 86-304 6.1e-11 36.3 In-house 76-307 (332) alignment 
Range on Protein: 86-304
Range on HMM: 76-307/332.0
TRDDYINASFIkDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIHL
 |. ||||| . .       .| | .. .  .  || ||.||..  ||.|| .    ..  ..  |.|..     ||| . |  ..    .    | . |
nrlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledve..lkleksdkyfpdktreelkfGildverkefvkrniletrllel

THlpTRQMRTITHLQFTAWPEFGVPSS------------PGVLLQFIDEVQSYHSQQRK------TQIPIvVHCSAGIDRTGVFCLVYTAAREIKEG-HG
.     .   . | ..  | |. .|               ||||    . . ..|  .|      .  || . .. |  |.||| ..    | | .  . 
sk..GnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapi.iqsarGsaraGvfvvidllirlidnkkkn

IADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARH
   . ... | . .|   .  . |  | |...| | ..
lysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 86-136 4.7e-06 20.3 In-house 68-117 (347) alignment 
Range on Protein: 86-136
Range on HMM: 68-117/347.0
TRDDYINASFIKdVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLL
  . ||||| ||    .|  .| || ||  .. ||| ||.  . . .| ..
dvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
0043147 (Phosphotyrosine protein) phosphatases II 87-295 3e-35 116.8 In-house 4-154 (172) alignment 
Range on Protein: 87-295
Range on HMM: 4-154/172.0
RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpatgkgstnfvsywpedkgaaqkfgdisvslqskrttdyhveriihlT
..||||||... ..   . |||||.||.  |.||| |..|.. ..||.| .                                                .
gsdyinasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltel...............................................l

HLPTRQMRTITHLQFTAWPEFGVPsSPGVLLQFIDEVQSYHsqQRKTQIPIVVHCSAGIDRTGVFCLVYTAAreikegHGIaDIPQVVKKLRLQRRWMIS
..|.  .|.. ..... || .||| .. .||.|.. .....  ... . |..||||||..|||.... |         .|. .. ..|. .| .|.... 
ydpellerlgiqylylpwpDhgvp.llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavq

EKEQLKFSY
 ..|..| |
npsqyrfly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 87-306 7.7e-25 82.6 In-house 45-263 (290) alignment 
Range on Protein: 87-306
Range on HMM: 45-263/290.0
RDDYINASFIKdvVPTSPCFIATQAPLQPS-------LNDFWLMVYEQQASIIVMLLSKPATGKGSTNF--VSYWPEDKGAAQKFGDISVSLQSKRTTDY
 |||| |....  .|   ..|.||.|..         ...|| |. . ..  .|||       .. ..|    | ||  |   ||....|. .|| . | 
nddyiHAnrvt..cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

HVERIIHLTHLPTRQMrTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYhsqqrktQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIADIPQVVKKL
  .| . ...   ... |.|| ..  | .  |. .. .||. |. |. .       . |..|||  || |  ..  .  .   | | .|   . .|.|.|
vetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvkas.......ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkal

RLQRRWMISEKEQLKFSYDAILCYARHAL
| ||  .|.....| |   .|. .| ..|
rkqralaitsalelafvdagivllaievl
subfamily_CG42327_pd Subfamily CG42327 87-225 3.1e-22 73.7 In-house 55-192 (319) alignment 
Range on Protein: 87-225
Range on HMM: 55-192/319.0
RDDYINASFIKDVVPTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATgkGSTNFVSYWPEDKGA--AQKFGDISVSLQSKRTTDYHVERIIH
.| |..||...    .   .||.|..|. |  ||| .|.|||. .|| | .      |      |.|  ..    . .||| |.|. . . | ..   . 
kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlsel..GikvcaeylPtketldntslyGdilvtlkgrevkdryaistll

LTHLPTRQMRTITHLQFtAWPEFGVPSSPGVLLQFIDEVQS
| ..   . | .||  .  |.| .||...  |.  . ||.|
lkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 87-175 9.2e-12 39.3 In-house 82-168 (350) alignment 
Range on Protein: 87-175
Range on HMM: 82-168/350.0
RDDYINASFIKDV---VPTSPCF--IATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpaTGKGSTNFVSYWPEdkgaaQKFGDISVSLQSKRTT
 .|||||...|     |   | |  |||||||.  ..||. .... .  .|..| |.     .   .  ||.|      .. || | |.||.  
tnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsd..velnlekcyrYWqe.....gsydditvklaskwen
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 87-208 5.6e-08 27.2 In-house 12-125 (130) alignment 
Range on Protein: 87-208
Range on HMM: 12-125/130.0
RDDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKpatgkgsTNFVSYWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIHLT
 ..||||||.  .   .  .. ||.||  .  ||| |. |.   ..|.| |         .   |||. .       || |.|  .   ..     ..  
gntyinasfvGllg.rtaeylltqhpladtsmdfwkmmleryvnvlvvlgsv.......eeedeywpdsePlewyeediivtltdrdefknikasnleie

HLPTRQMRTITHLQFTAWPEFG
.   .  ...| .| . ||  |
sdlneshqaltmfqisnwpsdg
0051429 (Phosphotyrosine protein) phosphatases II 88-305 4.3e-38 126.9 In-house 4-228 (272) alignment 
Range on Protein: 88-305
Range on HMM: 4-228/272.0
DDYINASFIKDVvpT----SPCFIATQAPLQPSLNDFWLMvYEQQASIIVMLLSKPATGKgsTNFVSYWP----------EDKGAAQKFGDISVSLQSKR
..||||....    .       ......||. . .||| . .|.. . ||.| |    |.   ..  |||          .|      .|...| |.|. 
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgr..lkcdrywpgirylhlpilddsaptilygalrvtllsee

TTDYHVERIIHLTHL-PTRQMRTITHLQFTAWPEFGVPSSPgvLLQFIDEVQSyhsqqrktQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIAD---
...... | . ||.| .. ..|...||..|.|| .|||...  ||........        . |..||||||.||||......  .. . .   ..|   
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll

----IPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHA
    . ..|..|| ||....   ||..| |.|.| ..|  
tnlyleeaveelraqrpgavqteeqylflyeallellrsl
0036282 (Phosphotyrosine protein) phosphatases II 88-295 2.2e-35 117.3 In-house 2-163 (174) alignment 
Range on Protein: 88-295
Range on HMM: 2-163/174.0
DDYINASFIKDVVPTSpCFIATQAPLQpslndFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEdkgaaqkfgdisvslqskrttdyhveriihlth
.||||||... .. |.  .||.|.||.     || |..|.. ...||||.     .|.. .  ||||                                 
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleeke..lglykcinywpe.................................

LPTRQMRTITHLQFTAWPEFGVPSSPGvLLQFIDEVQSYHSQqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKegHGIADIPQVVKKLRLQRRWMISE
|..   |.. ..... || .|||...  ||.|...|....|.  . . |..||||||..|||.... |   | ..  ..  |. ..|..||||| .|.  
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqt

KEQLKFSY
 .|..| |
psQyrfly
0051082 (Phosphotyrosine protein) phosphatases II 88-297 1.8e-28 94.4 In-house 3-148 (151) alignment 
Range on Protein: 88-297
Range on HMM: 3-148/151.0
DDYINASFIKDVvptspcFIATQAPLQpslnDFWLMVYEQQASIIVMLLSKPATGkgstNFVSYWPEDKgaaqkfgdisvslqskrttdyhveriihlth
.||||.|.. .       ......||.    ||. ...|.. . ||.| |.. .|    .. .|.||                                 
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg....ycpeylpelg...............................

lptrqmRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSyhsqqrKTQIPIVVHCSAGIDRTGVFCLVYTAAREikeghgiADIPQVVKKLRLQRRWMISE
      ....|.... ||..|.| |.  .|.|......      | . |..||||||..|||.....|  ..         .. .... .||.|  ..  
......ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqp

KEQLKFSYDA
..|  | . |
nqqflfqlfa
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 88-283 4.7e-23 76.2 In-house 66-249 (281) alignment 
Range on Protein: 88-283
Range on HMM: 66-249/281.0
DDYINASFIKDVVpTSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQKFGDISVSLQSKRTTDYHVERIIHLTH
 ||| | .|.  .     .| || | . .  ||| |....... ||||     | .   .   |.| .  .. .|  .||| .        |   . |..
tdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnr..ekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy

lpTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVqsyhsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIADIPQVVKKLRLQRRW
    . | |||  .  ||.. || |  |.|. . ..       |    | |.|||||. |.| .  |  | . |.    . || |.| .||.  | 
..egetrlithwlwkewpdwqvpessevmlkilrki.......rarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgra
0046846 (Phosphotyrosine protein) phosphatases II 89-301 3.4e-29 97.2 In-house 13-172 (176) alignment 
Range on Protein: 89-301
Range on HMM: 13-172/176.0
DYINASFIKDvvptsPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPATGKgsTNFVSYWPEDKGAAQkfgdisvslqskrttdyhveriihlthl
|||||..|       ...||||.||  .| ||. |..|.. ...|.|..   .|.   ..  |||| ...                              
dyinanlilg.....srpiatqgplprtladflemlkelgitavvnlteevelgr..lkcpnywpeleklgi............................

ptrqmrtitHLQFTAWPEFGVPSSpGVLLQFIDEVQSYHSQQrktqIPIVVHCSAGIDRTGVFCLVYTAAReikegHGIADIPQVVKKLRLQRR-WMISE
         . ... ||..|||..   ||......... ..      |..||||||| |||.... |   .     .   .. ......| ||. ...  
.........qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplgavqt

KEQLKFSYDAILCY
 ||..| |...| .
peQyrflyefelll
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 102-292 1.7e-23 77.8 In-house 88-271 (301) alignment 
Range on Protein: 102-292
Range on HMM: 88-271/301.0
TSPCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGAAQKFGDISVSLQS--KRTTDYHVERIIHLTHLPTR-QMRTITH
 .  |||||.||. . .||| |.   .   ||||  |    |  .   .| | . .   . |  .. ...  .   .  ..| ....    . . ||.||
hphrfiatqgPlkntsedfwamlvqydvekivmlgqkve..kleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvth

LQFTAWPEFGVPSSPGVLLQFIDEVqsyhsqqRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQVVKKLRLQRRWMISEKEQLK
 |.. |.. ||| |   | .... |       .|.. |||||||||| |.  |      |||..    | .. . .|.|| .|   .  ..|| 
yqysewtdrgvPkshaelfdlmelv.......kksekPivvhcsaGiGrsvafigteylareveadpti.eltealkhlrehrwngvqtnsqly
0049260 (Phosphotyrosine protein) phosphatases II 104-296 2.4e-25 84.4 In-house 9-144 (152) alignment 
Range on Protein: 104-296
Range on HMM: 9-144/152.0
PCFIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWpedkgaaqkfgdisvslqskrttdyhveriihlthlptrqmrtitHLQFTA
  |||||.|.  .|.||| |..|.....|||| .     .|   .  |.                                             . ... 
fefiatqgpgpntladfwrmlkelgittivmltelle..lgklkceqyi.............................................qylhlp

WPEFGVPSSPGVLLQFIDEVQSYhsqQRKTQIPIVVHCSAGIDRTGVFCLVYTAAreikeghGIADIPQVVKKLRLQRRWMISEKEQLKFSYD
|| .|||... .||.... .. .   ... . |..||||||..|||.... |             .. ..|. .| .|  ..  ..||.| |.
wpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 106-296 1.8e-23 77.7 In-house 7-198 (199) alignment 
Range on Protein: 106-296
Range on HMM: 7-198/199.0
FIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtGKgSTNFVSYWPEDKGAAQKFGDISVSLQSKRT-TDYHVERIIHLTHL-PTRQMRTITHLQFTA
.|||| ||. .. ||| ||.|  .  |||.       |  ...  |||  . .. |.| .||. ..  |  || .  .|           | |.| |||.
yiatqhplretmadfwqmvwetgsghivmvnddqk.nk.eadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEFGVPSSPgVLLQFID---EVQSYHsqQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGH-GIADIPQVVKKLRLQRRWMISEKEQLKFSYD
| |   |    ... |.    ||   .  ... . |..|||| |   ||||  .    |  .| .  . |. .| |.||  |  .||  .. .| |.
wkekttpnva.lfvgfvvasrevskky..eqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 106-296 1.8e-23 77.7 In-house 6-197 (198) alignment 
Range on Protein: 106-296
Range on HMM: 6-197/198.0
FIATQAPLQPSLNDFWLMVYEQQASIIVMLLSKPAtGKgSTNFVSYWPEDKGAAQKFGDISVSLQSKRT-TDYHVERIIHLTHL-PTRQMRTITHLQFTA
.|||| ||. .| ||| ||.|  .  |||.       |  ...  |||  . .. |.| .||. ..  |  || .  .|           | |.| |||.
yiatqhplretladfwqmvwetgsghivmvnddqk.nk.eadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEFGVPSSPgVLLQFID---EVQSYHsqQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGH-GIADIPQVVKKLRLQRRWMISEKEQLKFSYD
| |   |    ... |.    ||   .  ... . |..|||| |   ||||  .    |  .| .  . |. .| |.||  |  .||  .. .| |.
wkekttpnva.lfvgfvvasrevskky..eqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 112-312 9.7e-14 45.5 In-house 99-295 (302) alignment 
Range on Protein: 112-312
Range on HMM: 99-295/302.0
PLQPSLNDFWLMVYEQQASIIVMLLSkpATGKGSTNFVSYWPEDKGAAQKFGDISVSLQS-----KRTTDYHVERI----IHLTHLPTRQMRTITHLQFT
| . .|. .| .. . . .|.| | |     ..   . .|. .. |   |||  .|   |     .. || .  ..    |. ..  ... .|.  |.|.
pkkstlekhwalieqynvaivvqlcs..fvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPEFGVPSSPGVLLQFIDEVQSYhsqqrKTQipIVVHCSAGIDRTGVFCLVYTAaREIKEGHGIADIPQVVKKLRLQRRWMISEKEQLKFsydAILCYA
|||. | |  .   |. .   .||     |..  ..||||||. ||| .  .     ..   . ..|. ..|. .|  |   . ...|| .    .|| .
awpdhGapkeaytaldilkfcesy.....kkn..vlvhcsaGvGrtGtlvaikyG.iqlcskkkvtdllsivlpvrqcryGavqdeqqliy...lllcvt

RHALAKRGVA
.  ..| || 
kglmekagvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 116-300 5.7e-14 46.8 In-house 40-219 (255) alignment 
Range on Protein: 116-300
Range on HMM: 40-219/255.0
SLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGAAQKFGDISVSLQSkrTTDYHVERIIHLTHLP--TRQMRTITHLQFTAWPEFGVPSSP
... |. ..  .... .|||       .|  .  ||.| .|   .|. |..|.     ..   | | ...|      .. .|..| ... |.|   |  .
tvdkfyqtivqtktevvvmlcdfae..egvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

GVLLQFIDEVqsyhsqqRKTqIPIVVHCSAGIDRTGVFCLV---YT-AAREIKEGHGI-ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
  .|. .  |       |..  ..|||||.|| |.  | |.   |    | ... . .  |  .....|| .|.  | .  || ||   .| 
reilnilkvv.......rds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_hpo-7_pd Subfamily hpo-7 116-312 5.5e-12 40.1 In-house 46-237 (263) alignment 
Range on Protein: 116-312
Range on HMM: 46-237/263.0
SLNDFWLMVYEQQASIIVMLLSKPAtgKGSTNFVSYWPEDKGAAQKFGDISVSLQSKRTtdYHVERIIHLTH-LP-TRQMRTITHLQFTAWPEFGVPSSP
 .. |. ..  .... .|||       .|  .  ||.| .|   ||. ...|.          . . ..|.  |   ....|..| ... |.|   |  .
tidkfyqtivqtktevvvmLcDfne..egvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

GVLLQFIDEVQSYhsqqRktqiPIVVHCSAGIDRTGVFCL---VYT-AAREIKEGHGI-ADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYARHALAK
   |. .. ..      .    ..|||||.|| |.  | .   ||    | ... . .  |  .....|| .|.  | .  || ||   .| .  .. ||
reilnilkvarns....k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfak

RGVA
  . 
gele
0048076 (Phosphotyrosine protein) phosphatases II 162-298 1.3e-23 78.6 In-house 13-139 (145) alignment 
Range on Protein: 162-298
Range on HMM: 13-139/145.0
FGDISVSLQSKRTTDYHVERIIHLTHLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQqrktQIPIVVHCSAGIDRTGVFCLVYTAARei
.|.. . |. ..  |... ... ||. ..   |........ || .|||...  ||.|.. .......      |..||||||..|||.... |   .  
lgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmll..

kegHGiADIPQVVKKLRLQRRWMISEKEQLKFSYDAI
   .|  .........| ||....   .||.| |...
...lg.vsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 163-293 7e-20 66.7 In-house 14-136 (144) alignment 
Range on Protein: 163-293
Range on HMM: 14-136/144.0
GDISVSLQSKRTTDYHVERIIHLTH--LPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSqqrkTQIPIVVHCSAGIDRTGVFCLVYTAAre
|.. ..|. ..  ....  .| ||.   |.   |........ || .|||...  ||.|.. ......       |..||||||..|||.... |     
gslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk..

ikeGHGiADIPQVVKKLRLQRRWMISEKEQLKF
    .|  .. .... .| .| ...   .||.|
...klg.lsleealalvrsrrpgavpnpgqlrf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 187-299 9.5e-15 48.8 In-house 82-191 (440) alignment 
Range on Protein: 187-299
Range on HMM: 82-191/440.0
HLPTRQMRTITHLQFTAWPEFGVPSSPGVLLQFIDEVQsyHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIaDIPQVVKKLRLQRRWMIS
..   . ||. . .. .||. |||   | .|..|..|.  .||..  . |..||||||  ||||   | .  || |    | ||  ... .| .|  |. 
yingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvn..esqekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrnnrpqmvq

EKEQLKFSYDAIL
  ||  | ..|.|
tpeqyafvheavl
PTPc_DSPc_SM00012 195-299 1.2e-29 98.0 In-house 1-104 (105) alignment 
Range on Protein: 195-299
Range on HMM: 1-104/105.0
TITHLQFTAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKtQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIADIPQVVKKLRLQRRWMISEKEQLKFS
|..|...|.||..|||...  .|.....|.. .... . . |.|||||||..|||.|...... . ......  || |.||.|| ||..|....||  | 
tvkhyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YDAIL
|.|.|
yrall
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 195-303 3.8e-12 40.6 In-house 216-345 (350) alignment 
Range on Protein: 195-303
Range on HMM: 216-345/350.0
TITHLQFTAWPEFGVPSSPGVLLQFID-------EVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYT-------------AAREIKEGHGIAD-IPQV
 . .||.  |.. ..   |  .|| ..       .  .    . . . ||.||||||. |||... .                 |...    . | | ..
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKKLRLQRRWMISEKEQLKFSYDAILCYAR
|..|| ||  |. ...|  | |.|.| | .
vnelrkqrismvqnldqfifiYeallfyfa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 196-301 3.6e-07 23.8 In-house 220-343 (349) alignment 
Range on Protein: 196-301
Range on HMM: 220-343/349.0
ITHLQFTAWPEFGVPSSPGVLLQ-------FIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAR----------EIKEGHGIAD-IPQVVKKL
.  ||.  |.. ..   |  .||       .||.  .    . .   ...||||||  ||||.. .                ||      | |  .| .|
llqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnel

RLQRRWMISEKEQLKFSYDAILCY
| ||  |. .  |  . |.|.| |
rkqrismvqnlaqfiaiyealLky
0038934 (Phosphotyrosine protein) phosphatases II 202-258 2e-08 29.6 In-house 85-139 (194) alignment 
Range on Protein: 202-258
Range on HMM: 85-139/194.0
TAWPEFGVPSSPGVLLQFIDEVQSYHSQQRKTqiPIVVHCSAGIDRTGVFCLVYTAA
  .|..|.. |  .||.|.| |. ..... .    ..||| ||. |||...  |   
lpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiy
0048567 (Phosphotyrosine protein) phosphatases II 202-255 4.9e-06 21.0 In-house 43-98 (157) alignment 
Range on Protein: 202-255
Range on HMM: 43-98/157.0
TAWPEFGvPSSPGVLLQFIDEVQSYHSQQRKTQIPIVVHCSAGI---DRTGVFCLVY
. . .|| | . ..| .||  . .. .. ...  .|.|||.||     ||....  |
dfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcY
subfamily_DSP11_pd Subfamily DSP11 213-255 7.9e-06 19.9 In-house 95-137 (178) alignment 
Range on Protein: 213-255
Range on HMM: 95-137/178.0
PGVLLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVY
  .. .|...|...  .. ...  | |||  |..||| .   |
eelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCry
PTPc_motif_SM00404 216-256 5.3e-07 24.6 In-house 62-102 (140) alignment 
Range on Protein: 216-256
Range on HMM: 62-102/140.0
LLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYT
|....|.| .. .. .|..  ..||| ||. |.. ....| 
lskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl
DSPc Dual specificity phosphatase, catalytic domain 216-255 4.4e-06 21.6 Pfam-A 55-94 (133) alignment 
Range on Protein: 216-255
Range on HMM: 55-94/133.0
LLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVY
. ....|. .. .. .. .  ..||| ||| |.. ....|
iskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaY
DSPc Dual specificity phosphatase, catalytic domain 216-255 4.4e-06 21.6 In-house 55-94 (133) alignment 
Range on Protein: 216-255
Range on HMM: 55-94/133.0
LLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVY
. ....|. .. .. .. .  ..||| ||| |.. ....|
iskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaY
subfamily_DSP12_pd Subfamily DSP12 216-256 8e-06 20.3 In-house 64-104 (155) alignment 
Range on Protein: 216-256
Range on HMM: 64-104/155.0
LLQFIDEVQSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYT
.|...||. .. .. ....  ..||| ||. |   ... | 
iLshldeavdFieealeeegavlvHCqagvSRSvtiviAYl
subfamily_CG42327_pd Subfamily CG42327 224-303 3.8e-13 43.8 In-house 237-316 (319) alignment 
Range on Protein: 224-303
Range on HMM: 237-316/319.0
QSYHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHGIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILCYAR
 | .| .|. | |.||||| |. |||.      | |...| .   ||||.|  .| .|   . .||| .| |  .  ||.
issrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 224-300 9e-11 36.2 In-house 219-293 (297) alignment 
Range on Protein: 224-300
Range on HMM: 219-293/297.0
QSYHSQQRkTQIPIVVHCSAGIDRTGVFCLVYTAAREIKEGHgIADIPQVVKKLRLQRRWMISEKEQLKFSYDAILC
.|.....   .....||||||. |.||  |  . .  .. .. | |.  ....|| ||  ..   || .. |||.| 
eslraemp.rnayllvhcsaGvGrsGvvvlsdvilaklrkkr.ipdvaailsilreqrarlvqtleqfellydavlk
Y_phosphatase3 Tyrosine phosphatase family 226-263 1.6e-06 23.2 Pfam-A 116-153 (164) alignment 
Range on Protein: 226-263
Range on HMM: 116-153/164.0
YHSQQRKTQIPIVVHCSAGIDRTGVFCLVYTAAREIKE
. .. .... |...||.|| |||||.. .  .. ...|
vlealaeeegpvlfHCtaGKDRTGvvaalllsllgvde