Gene PTPN3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP061_AA protein Get Run
SpurP061_AA_368-647 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_C FERM C-terminal PH-like domain 12-96 1.4e-26 82.9 Pfam-A 4-87 (90) alignment 
Range on Protein: 12-96
Range on HMM: 4-87/90.0
GSEIAIGVVSAGLSIFQNGVRI--NQFSWAKIVKISFKRKQFFIQQRReigETRDMVIGFNMTSYRACKNLWKSCVEHHTFFRMVDP
|.....|| . || |...  ..  ..|.|..| |.|||.|.|.|..|    |... |. |.....|..|.|.|.|.|.|..||   .
gtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd...ekkkdvlkFyssqlrvnklllklcienhdlfrrrrk
FA FERM adjacent (FA) 104-147 8.5e-14 40.2 Pfam-A 2-45 (47) alignment 
Range on Protein: 104-147
Range on HMM: 2-45/47.0
TFFQLGSKFRYSGRTESQTMEDTKKRLAEKEISRSSPNKRAFRR
 || |||||||||||| |..|. ...  ...    || ||  .|
kffslGSkFRYSGRTekQvieesreigrkppsfeRspskrylsr
PDZ PDZ domain (Also known as DHR or GLGF) 252-325 8.2e-20 60.9 Pfam-A 2-74 (81) alignment 
Range on Protein: 252-325
Range on HMM: 2-74/81.0
IRMLPDDRGRFGFNVKGGADQG-APIIVSRVAPNtPADLCIPrLNEGDQILQINGKDASTFTNEQLVSTIRALGE
... .. ||..||..||| |..  .|.||.| |. .|. . . |.|||.||..||.| ....... |  |.  ..
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkg
0050432 (Phosphotyrosine protein) phosphatases II 366-648 2.5e-91 301.5 In-house 24-301 (308) alignment 
Range on Protein: 366-648
Range on HMM: 24-301/308.0
EIDSLTESFMLLQEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILreADTGDYINANTINMDIpgFDLVNKYVAAQGPLPN
.  |. .   ||.. ||.|.  ..| .|...|| ... ...| ||. ||||.|| ||| .||.|   .. |||||. ... .  ..| .|..|.||||||
lklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgys..sklprkfIatqgPlpn

TVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDL--DDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSD
||.||| |||||....|||||. ||.||.||..|||.   .. |..| .. |....... ... .| ....|. ..|.|.| ...| .|||||||.. ..
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg.kftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

FLDFVLRVRQCRvgMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMD
.|||. .||...   . |..||||||.||||..|.........|..  | ....|.. | |||. .||  ||.|...|..  ...
lldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Ptp69D_pd Subfamily Ptp69D 367-647 5.3e-66 217.8 In-house 6-287 (307) alignment 
Range on Protein: 367-647
Range on HMM: 6-287/307.0
IDSLTESFMLLQEGLDTGMAIaQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipGFDLVNKYVAAQGPL
||.|.|..   ..  | |.|   ...| ...   .  .    ||  |||| || ..| |||.|..    .. |||||. |.    |..  .|..|||.|.
iddleealksrkrdtdfglak.eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik....gykekkkfiaaqdPv

PNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDlDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTA-----TKEERIVLQMQYVAWPDHGVP
 .|..||| |..|| .||||||.   |  | ||.||||. .|  ..| |. |.. . .... .. |.. . ..       ...| |.| .| .|.|  ||
eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpi.edevqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP

DDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
. .   |... .||.       | .|||||| ||.|......  .  ..|.. |   ..|.  | ||..|.|  .||.|.  |..   .
evargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 367-644 1.2e-65 216.6 In-house 7-281 (319) alignment 
Range on Protein: 367-644
Range on HMM: 7-281/319.0
IDSLTESFMLLQEGLDTGMAiAQFDQLYRKKPGmTMGACRLAENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPL
.. | | .. |..  .|...  .| .|   ..  |.  .   ||  ||||..| .|| |||.| | |     |||||. |.    |..  .|..|.|.||
vqeLkerlkalastgetlle.kefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid....gyqerekfiatqaPl

PNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDdRLKFGpDLEVRCTRCDETPSFAYRDFIIcNTATKEE--RIVLQMQYVAWPDHGVPDDS
 ||..||| ||||..|  .||||  ||...||..||||. .   ..|  | |     .|.  .  |.. . |... |   | | . || .||||.||...
entiedfWrmvWeeessivvmltklveklkvklkkywpeen.feeyG.rlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPeka

SDFLDFVLRVRQCRVG-MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
   ||.. |.|. | .  . | .||||||.||||  |... ..  .. .. .    .|.. | ||....|. .||||. ||.. 
tslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle
subfamily_PTPN3_pd Subfamily PTPN3 370-651 2.3e-147 484.3 In-house 1-280 (280) alignment 
Range on Protein: 370-651
Range on HMM: 1-280/280.0
LTESFMLLQEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADTgDYINANTINMDIPGFDLVNKYVAAQGPLPNTVND
|.||..||.|||..|. .|||.||||||||... |.|..||..|||||||.|||||||.|.|..| ||||||..||.||. .|||.|.|.||||..|..|
lresllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatd

FWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVL
||.|||||.|.|||||||.|||||||||.|||. .|.|..| ...|.|...||| |...|........||||| .||.||.|||||||||||.|||.|| 
fWqmvweqksslivmlttlverGrvkChqyWPetedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefve

RVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMDCIV
|||..| |.. |..||||||||||||||..|||..||||.||||||||||| |||| ||.|||.|||||||||..||....|
rvrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyeeilv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 372-640 5e-31 102.4 In-house 15-284 (310) alignment 
Range on Protein: 372-640
Range on HMM: 15-284/310.0
ESFMLLQEGLDTGMAIAQFDQLYR-KKPGMTMGAcrLAENVAKNRYRDIAPYDATRVILR--EADTGDYINANTINMDIpgfdLVNKYVAAQGPLPNTVN
| |..  | |     . |. .|   . . .|. |    ... |||| |.   |..|| |.   .  .||| || .. .     | . .. .||||  |. 
enfiiateklgieglvkqyrkldakqdssltyea..ykkymhknrysdvvcldtsrvklkidksryedyihanyvktny....lrstficsqgplqhtii

DFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGPdleVRCTRCDETPsfayRDFIICNT---------------ATKEERIVLQMQYVAWP
||| |....|.  |..|   .| || ||  ||| |     .|    .| |   |.      .| |||                |  .|  |  ...  ||
dfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygc...irvtnlsess....eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwp

DHGVPDDSSDFLDFVLrVRQCRVGmdvPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCE
| ||||.    .   | . | | |   | .||||||..|..|..... ..  ..  . |   ...   . .| . |||  || ..  
drgvpdekchtvpqrl.laqvrhg...pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_PTPN14_pd Subfamily PTPN14 374-644 2.4e-68 225.4 In-house 13-294 (300) alignment 
Range on Protein: 374-644
Range on HMM: 13-294/300.0
FMLLQEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREA--DTGDYINANTINMDIPGFDlvNKYVAAQGPLPNTVNDFW
.  |.. |. |.  ...... .|.   .. ...| ||. |||..|. ||. .|| |  .  .. .|||| .|.. . | .   .|..|||||..||.|||
akilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggke..rsyivaqgPleltvqdfW

YMVWEQRSTLIVMLTTNVERGRVKCHKYWPDL---DDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFV
 |||||  .|||||| . | |. |..||.|.|    ....||   .|     ....|.. . . .    .|||| |. .||. |||||||.| ..||...
qmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgk.fkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyL

LRVRQCRVGM---------DVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
 .|.  |  .         . | .||||||.|||||||. .  .  .| || .    .... | || .|.|| |||||| ...|.
eevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
0039614 (Phosphotyrosine protein) phosphatases II 375-645 3.6e-78 258.3 In-house 23-288 (297) alignment 
Range on Protein: 375-645
Range on HMM: 23-288/297.0
MLLQEGLDTGMAIAQFDQLYRKKPGmtMGACRLAENVAKNRYRDIAPYDATRVILREADT----GDYINANTInmdiPGFDL-VNKYVAAQGPLPNTVND
 ||   ..... ...| .|.. ||   .  ..| ||. ||||.|| ||| .||.|   |      |||||. .    .|.||  .|..|.|||||.||.|
lllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPlpetved

FWYMVWEQRSTLIVMLTTNVERGRvKCHKYWPDLDDrlKFGPdLEVRCTRCDETPSFAYRDFIICNtaTKEERIVLQMQYVAWPDHGVPDDSSDFLDFVL
|| |||||..| |||||. ||.|| ||..|||.  .  ..|. . |....... . . .| . . |  ..|.|.| ..||. |||||||......|.|. 
FwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygd.ftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefle

RVRQCRVG--MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRV
 ||...     . |..||||||.||||..|.. ......| .  | .|..|.. | |||. .||  ||.|...|..  
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_PTPN13_pd Subfamily PTPN13 376-645 1.4e-80 265.5 In-house 3-268 (273) alignment 
Range on Protein: 376-645
Range on HMM: 3-268/273.0
LLQEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADTgdYINANTINMDIpGFDlVNKYVAAQGPLPNTVNDFWYMVW
 ||. || ..   .|..|   ||  |    . .|| .|||||.. |||.|||.| .  .  ||||. |.. . | |   .|.|.|||||.||.||| |||
alqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpv.gkd.eyeyiacqGPlPetvkdfwqmvw

EQRSTLIVMLTTNVERGRVKCHKYWPDLD-DRLKFGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQC
||....|.|.|...|.|.||||.|||.   ..||    |||.  .  .  .|. |.. . .....| | | ....|.|||||||  . ..| || .||. 
eqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl

RVgMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRV
.     | .|||||||||.|.|||..... ||| ....   .|||. |.||  ..||  || || .||. |
qt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 376-650 3.7e-73 241.4 In-house 13-283 (318) alignment 
Range on Protein: 376-650
Range on HMM: 13-283/318.0
LLQEGLDTGMAiAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREA---DTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWY
 |.|  .. .  .....| |..  .|        | ||||| .| .|| ||| |..     . |||||| |    .|.   ..|.|||.|||.|..||| 
rlresGellls.eeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi....dGyrrkkayiaaqaPlpetieDfWr

MVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDrLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVR
||||| |..|||||  .|||..|.|.|||. .   ..| .| |  .   |. ..  | | . .| ..|.|.| | .| .|||.|||......||.| .|.
mvWeqnsavivmltqeeergkakvhryWPskgs.rsyg.klvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvs

QCRV-GMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRvYMDCI
.        |..||||||.||||| |.... .  |.|.. |  ...|.. |.||....||  ||.|. ....  .. . 
kaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlle.alasg
0047943 (Phosphotyrosine protein) phosphatases II 377-643 1.9e-84 278.6 In-house 5-269 (273) alignment 
Range on Protein: 377-643
Range on HMM: 5-269/273.0
LQEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILrEADTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWE
|.. |.... ...|..|.. || .|. ...| ||  ||||.|| ||| .||.| . .. |||||. .    .|..| .|..|.||||||||.||| ||||
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmvwe

QRSTLIVMLTTNVERGRVKCHKYWPDLDDR-LKFGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCR
|....|||||. ||.||.||..|||.  .   .   .. |....... ...  | ... |. |.|.|.| ...|  |||||||.. ...|.|.  ||...
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

VG--MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
     . |..||||||.||||..|.........|..  | .|..|.  |.|||. .||  ||.|..||..
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0036941 (Phosphotyrosine protein) phosphatases II 378-653 2.8e-85 281.5 In-house 7-284 (297) alignment 
Range on Protein: 378-653
Range on HMM: 7-284/297.0
QEGLDTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILrEADTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQ
 . |.. .   .|..|.. .. ... . .| ||. ||||.|| ||| |||.| . .  |||||. .    .|.|| .|..|.||||||||.||| |||||
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyv....dgydlkrkfIatqgPlpntvedFWrmvweq

RSTLIVMLTTNVERGRVKCHKYWPDL-DDRLKFgPDLEVRCTRCDE--TPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQC
..| |||||. ||.||.||..|||.  .. |..  |. |.......   ... .| . . .| ..|.|.| ...|  |||||||.. ...|||. .||..
nvtvIvmltelvelgrekcaqywpleegeslty.gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

RVG--MDVPTIVHCSAGIGRTGVLITMETAMCLIE---ANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMDCIVKP
.     . |..||||||.||.|..|.........|    .. | .|..|.. |.|||. .||  ||.|..||..  ..   .|.
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 380-646 5.1e-23 75.9 In-house 22-285 (302) alignment 
Range on Protein: 380-646
Range on HMM: 22-285/302.0
GLDTGMAIAQFDQLYRKKPGMTMgaCR-LAENVAKNRYRDIAPYDATRVILReADTGDYINANTINmdIPGFDlvNKYVAAQGPLPNTV---NDFWYMVW
 |||.   ..|...   |  . .  |.   .|..||.  |.  .|...|.|  |   .|.|| ...  .| .   .. . || |  ...   ..|| ||.
sldtaevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkle.aepdsyvnaskve..vPelt..rsiilaQlpkvdsedsveeFWrmvf

EQRSTLIVMLTTNVERGRvKCHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAyRDFIICNTATKEERIVLQMQ--YVAWPDHGVPDDSSDFLDFVLRVRQ
... . .|.|  . |  .   ....| . .  |   .. |   . ...   .   ..|          || .      |... ||.  ..    .  | .
qekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfa

CRVGMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
  .  | .|..    |.|| |...|. .|.. ..... .   .||.. | |||  .... || ..  |..   
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 381-646 4.7e-38 125.9 In-house 11-277 (307) alignment 
Range on Protein: 381-646
Range on HMM: 11-277/307.0
LDTGMA--IAQFDQLYRKKPG-MTMGAcrLAENVAKNRYRDIAPYDATRVILRE-ADTGDYINANTINMDIPGfdlvNKYVAAQGPLPNTVNDFWYMVWE
|| |.   . .| .| .|.|  .|. |  .  |  ||||.|.   | .|....    . ||| || . . |      .|...||||| ||. .|| |. .
ldkgvqalvdefrvlakktpegvtvea..fsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp....kkficaqgplentqysfwamaiq

QRSTLIVMLTTNVERGRVKCHKYWPDLD-DRLKFGPDLEVRCTRCDETPSFAYRDFIICNTA-----TKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLR
..   ..||   .| ...||..|||  . ..| ||   .  .     .  .|  . .|  |.     ... | . ..|.  |||.|||.     ....  
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea

VRqcrvGMDVPTIVHCSAGIGRTGVLITMETAMCL-IEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
||    .   | .||||||.||.| ....   .   |.  .     ..|.  |.||.  ||| ||| ..   ..  .
vr....ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0051299 (Phosphotyrosine protein) phosphatases II 382-644 2.6e-88 291.5 In-house 21-284 (288) alignment 
Range on Protein: 382-644
Range on HMM: 21-284/288.0
DTGMAIAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADT---GDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQR
.. . ...|..|....| .|. |..| ||. ||||.|| ||| .||.|.  |    .|||||. |    .|..| .|..|.||||||||.||| |||||.
gltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpntvedFWrmvweqn

STLIVMLTTNVERGRVKCHKYWPDlDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNT----ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQC
...|||||. ||.||.||..|||. .. |..|. . |....... ... .| ... |.     ..|.|.| ...| .||||||||. ...|||. .||..
vrvIvmltklvelgrekcaqYwpl.ggsltygd.itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrka

RVGMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
.   . |..||||||.||||..|.........|... | .|..|.. | |||...||  ||.||.||.. 
lasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 382-642 8.9e-19 62.2 In-house 20-275 (303) alignment 
Range on Protein: 382-642
Range on HMM: 20-275/303.0
DTGMAIAQFDQLYRKKPGmTMGACRLAENVAKNRYRDIAPYDATRVILREAdtgDYINANTINMDIpgfdlVNKYVAAQGPLPNTVNDFWYMVWEQRSTL
|. .|. .|...    |  ..   .. .|. |||. |.   | ..| | ..    || |. ...|       .| . .| ||. |  ||| |. ||.   
daniavnefekvvsylpp.svsknqfvknmdknrfvdvicldhskvklsds...syihasylelds.....skkailtqlplshtaadfwqmiieqkvkc

IVMLTTNVERGRVKCHKYWPDLDDRLKFGpDLEVRCTRCD---ETPSFAYRDFIICNTATKeeRIVLQMQYVAWPDHGVPDD-SSDFLDFVLRVRQC--R
...| |. |  ..  .  .|  .| |||  .  .|         .  .. .   . |   |   ..   .| |||   .| | |. |.  . ...    .
vlllltdseydklggdsvfprnqdflkfe.ersirvgefkrvelgdgwvlkvlsvsngdyk..sflhvhhykawphnsipsdgspkfvkqiwqlqsvlrk

VGMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPL-DIVRTERDQRPMLIQTAAQYKFVCEAI
     ||.    .| ||.| .  .|||   . ....   |   . . |. |   .|  .|. .|   .
ysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll
0043336 (Phosphotyrosine protein) phosphatases II 383-643 3.5e-80 264.7 In-house 19-274 (278) alignment 
Range on Protein: 383-643
Range on HMM: 19-274/278.0
TGMAIAQFDQLYRKKPgMTMGACRLAENVAKNRYRDIAPYDATRVILREADT---GDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRS
  . ...| .|.. |. .|.  ..| ||. ||||.|| ||| .||.|   .     |||||...    .|..  .|..|.|||||.||.||| ||||...
ktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgv

TLIVMLTTNVERGRVKCHKYWPdlDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMD
| |||||. ||.|||||..|||  .. |..|. . |....... . .  |.. . |. ..|.|.|....|..|||||||.. |..|||. .||...   .
ttivmLtelvelgrvkcaqYwp..ggsltygd.ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsn

VPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 |..||||||.||||..|.........| .  | ....|.. | |||. .||  ||.|..||..
gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0040438 (Phosphotyrosine protein) phosphatases II 384-649 2.6e-83 275.2 In-house 18-279 (317) alignment 
Range on Protein: 384-649
Range on HMM: 18-279/317.0
GMAIAQFDQLYRKKPGmTMGACRLAENVAKNRYRDIAPYDATRVILREADT---GDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRST
..   .| .|.. |.  |.   .| ||  ||||.|| |||..||.|   .     |||||. .    .|..| .|..|.||||||||.||| |||||..|
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvweqgvt

LIVMLTTNVERGRVKCHKYWPDlDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDV
.|||||. .|.||.||..|||. .. |..|. . |... ..| ... .| . . .. ..|.|.| ...| .|||||||.. ...|||. .||... . . 
vivmLteleelgrekcaqYwpl.getltygd.ftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpgg

PTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMDC
|..||||||.||||..|.........| .. | . ..|.. | |||. .|| .||.|...|..  ..  
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 386-642 4.4e-29 96.4 In-house 17-267 (288) alignment 
Range on Protein: 386-642
Range on HMM: 17-267/288.0
AIAQFDQLYRKKPGM--TMGACRLAENVAKNRYRDIAPYDATRVILReADTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIV
|..  .. ||  |       .    .| ...||...   |.||| |   |.  ||.|| .          .. . || ||  |.. .| |. |.    ||
aveglkkeyrdspneasidiidsfianptrdryenlprcditrvkls.ddpdfyiaanvvs....sakykrrlicaqaPlngtieelWkmllesdveyiv

MLTTNVERGRVKCHKYWPD-LDDRLKFGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRvgmdVPT
||.  .|.|. |  .|.|  | .. ..|    |   . ..         .  .  ..|. || .. .  |.|.|||..   .| .. ......     | 
mlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPi

IVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAI
.||.|||.|||| || .  |.  .  .. .    ..   |..|   |||  || .|   .
vvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 387-646 1.3e-76 252.4 In-house 18-276 (281) alignment 
Range on Protein: 387-646
Range on HMM: 18-276/281.0
IAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIV
| ....|.    . |  | .  ||| ||||..|  |||||| .    |. . |||||| .    ||..  ..|.|.|||.|.....|| |||||. ..||
ieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfv....pgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLTTNVERGRVKCHKYWPDLDDRLKFGpDLEVRCTRCDETPSFAYRDFIIcNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV-GMDVPT
|.| ..| |..|||.|||| . .||.| |. |. |.  |..... | | . .. . |.| | |..|.||||||||......|.|   |....    ..| 
mvtreieagklkChrYWPddnselkyg.dvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkapl

IVHCSAGIGRTGVLITMETAMCLIEAN-EPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
..|||||.||||. |......  .||. |.. . ..|.  | .| ...|| .||.||  |.... 
vihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
0045098 (Phosphotyrosine protein) phosphatases II 387-646 6.5e-75 247.4 In-house 10-272 (278) alignment 
Range on Protein: 387-646
Range on HMM: 10-272/278.0
IAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVIlreadtgDYINANTINMDiPgfdlvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLT
  .|..|..  .  ..    . .|..||||.|| ||| .||.       |||||. |..  |     .|..|.|||||.||.||| |.||...| |||||
llefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy.p.....kkfIatqgPlpstvadfwrmlwelgitvivmlt

TNVERGRVKCHKYWPDlDDRLKFgPDLEVRCTRCDETPSFAYRDFIICNT----ATKEERIVLQMQYVAWPDHGVPDDS--SDFLDFVLRVRQCRV----
. ||.||.||..|||. .. | .  |..|... ..... . .|.....|.    .. |.| | ...|. |||||||...  . ||... ..|...     
elvelgrekcaqywpe.ggslty.gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

---------GMDVPTIVHCSAGIGRTGVLITMETAMCLIeaNEPVYPLDIVRTERDQRPM-LIQTAAQYKFVCEAIIRVY
         . . |..||||||.||||.|. . . ..|.  .. | .|..|.. | |||.  .|.  ||.|..|......
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN12_pd Subfamily PTPN12 387-647 6.7e-68 223.7 In-house 17-278 (290) alignment 
Range on Protein: 387-647
Range on HMM: 17-278/290.0
IAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREA---DTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIV
. .  . |...  ..  | .  |||.||||.|| ||| .|| |..    .  |||||| |.    | .   .|.|||||||.|..||| |.||.. ...|
lkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfik....gvegkleyiaaqgPLpktlddfWrmiweknveivv

MLTTNVERGRVKCHKYWPDL-DDRLKFGpDLEVRCTRCDETP-SFAYRDFIIcnTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVP
|.  .|| |. ||..|||.  ...|.|| ..|| ... . .   |  | . .  .| ||.|.| |..| ||||||||   .. |...  ||. .   |.|
maCrevelgkkkCerYWpeegeeelefg.efevtleeekavdddflirtLkv..eaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaP

TIVHCSAGIGRTGVLITMETAMCLIEANEP---VYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
 .||||||.||||..|... .  |..|.     .   |.|.. | ||. |.||  ||..| .|.. .  
lvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 387-577 5.3e-39 128.8 In-house 10-199 (297) alignment 
Range on Protein: 387-577
Range on HMM: 10-199/297.0
IAQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADTG-DYINANTINMdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVML
 |. | |.... | .. ...    . |||||||  .| ||| |. . |. |||||. . .  |  .   ||. ||||| .||.||| .|.||    |||.
eaekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf..pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv

TTNVERGRVKCHKYWPDLDDRLKFGPDLEVR--CTRCDETPSFAYRDFIICNTatKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVG
.   | || ||  |||. ..  .  .|. |    .  ||       .. .     .|.| |  .|...||||||| |  |   |  .|  | . 
aklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcsccia
0046845 (Phosphotyrosine protein) phosphatases II 388-647 2.2e-84 278.5 In-house 4-275 (284) alignment 
Range on Protein: 388-647
Range on HMM: 4-275/284.0
AQFDQLYRKKPGM--TMGACRLAENVAKNRYRDIAPYDATRVILREADT----GDYINANTINMD-IPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRST
..| .|.. .. .  .. ...| ||. ||||.|| ||| .||.|.  |     .|||||. ...  .. ..  .|..|.||||||||.||| |||||...
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

LIVMLTTNVERGRVKCHKYWPDLDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTA-TKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV--G
.|||||. ||.||.||..|||. .. |..|. . |....... ... .| . . |.  |.|.|.| ...| .|||||||....|.|.|.  ||...   .
vIVmltelvengrekcaqYwplegevltygd.ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

MDVPTIVHCSAGIGRTGVLITMETAMCLIEANE---PVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
 . |..||||||.||||..|.........|...    | .|..|.  |.|||. .|| .||.||.||..  ..
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0045450 (Phosphotyrosine protein) phosphatases II 388-646 3.6e-81 268.5 In-house 31-304 (307) alignment 
Range on Protein: 388-646
Range on HMM: 31-304/307.0
AQFDQLYRKKP--GMTMGACRLAENVAKNRYRDIAPYDATRVILREAD----TGDYINANTINMDI----PGFDLVNKYVAAQGPLPNTVNDFWYMVWEQ
..| .|.. ..   ... . .| ||  ||||.|| ||| |||.|   |    ..|||||. .....    .|.|| .|..|.|||||.||.||| |.|||
kefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweq

RSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNT-ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV
..|.|||||. ||.||.||..|||| .. | .|. . |.... .. ... .| . . ..  |.|.|.| ...| .|||||||.. ...|||. .||... 
gvtvivmltelvelgrekcaqywPdegeeltygn.ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkale

G--MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEP---VYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
    . |..||||||.||||..|.. ......|...    | .|..|.. |.|||  .|.  ||.|..||..  .
elpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPRB_pd Subfamily PTPRB 388-646 3.3e-79 261.0 In-house 29-285 (293) alignment 
Range on Protein: 388-646
Range on HMM: 29-285/293.0
AQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVM
 ....|   .  ... | .||.| |||||..| |||..|| |   .. .. ||||||     |||.   ....|.|||||.||.||| ||||..|. |||
eeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany....ipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LTTNVERGRVKCHKYWPDLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNtaTKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCR--VGMDVPT
||  ||.|.|||..|||. ..   .| |..|  .  .|.  .. |.. |..  .|||| | |.....|||||||.... .|||| .||.       . |.
ltqlvekgkvkCeeYWPadeepvlyG.dikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPi

IVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
.||||||.||||..|.... .  || .. |  . ||   | .| .|.|| .|| |. ...... 
vvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPN9_pd Subfamily PTPN9 388-644 4.4e-63 208.1 In-house 20-288 (297) alignment 
Range on Protein: 388-644
Range on HMM: 20-288/297.0
AQFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVM
 .. .. ....  |. | .|  |. |||| |.  || ||| | .    .. |||||| ..    |.   . ..|.||||..||.||| |||||.   |||
keyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvd....GykqkkafiatqGplkktvsdfWrmvWeqevlvivm

LTTNVERGRVKCHKYWP-DLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV------G
 |  |||||.|| .||| . ... .|| ||.|.    .|.  .  | . | |. |.|.| |   |...|||.|||......||..  ||. .       |
ttrvvergrlkcgqyWpleeessaefg.dlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelg

-------MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
        . | .||||||||||| .||.. ..  .|  . |   . |.. | ||   |||  ||.|   |.. 
dewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 388-644 4.8e-63 208.1 In-house 26-281 (305) alignment 
Range on Protein: 388-644
Range on HMM: 26-281/305.0
AQFDQLYRKKPGMTMGacRLAENVAKNRYRDIAPYDATRVILREADTGD---YINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVM
||...||...  . .|  .  .|.||||...| ..|  |.||.| .. |   ||||. ..    |..  .||..|||||.|||.|||....| . . |||
aqykslyeeeesidvg..kkeankaknrlkeitlldddriiltekeslddsdyinasyvd....gykrkkkyivaqgPlkntvadfWrliveekvstivm

LTTNVERGRVKCHKYWPDLDDR-LKFGpDLEVRCTRCDETPSFAYRDFIICN-TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV-GMDVP
||  || |. ||..|||.   .  .|| ...|  .   ... .  |.. |..    ||.| |||.|   |||||||. .. .|... ||.. .  . .||
ltklveggkdkCrqYWpesktekkefg.efsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvp

TIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
 .||||||.||||| |... |.  ... | |   ..... | .|. ..|| .|| |. .|.  
llVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_CG7180_pd Subfamily CG7180 388-647 4.1e-46 152.0 In-house 17-291 (296) alignment 
Range on Protein: 388-647
Range on HMM: 17-291/296.0
AQFDQLYRKKPGMTMGACRL---AENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTL
......... | ...| |.    .||  |||. .. ||| .||.|.. |   . |||||  ..    .|   ..|.  ..|  .||..|| .|... .  
veyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvd....sflkkkeyivteapkketvdefWrlvydeeisa

IVMLTTNVERGRvKCHKYWPDLDdRLKFGPdLEVRCTRCDETPSFAYRDFIICNT----------ATKEERIVLQMQYVAWPD-HGVPDDSSDFLDFVLR
.|.|| . .  . ....|||    . ..|. ..|  .. .. . .  | | .  .           . |.|||...|.  |.  . ||  .. ..... |
vvvLtktfdfak.mypsywpnks.keqyge.ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VRQCRVGM-----DVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
||. |  .       |..|..| | .|.|| .... .. |.| .| |   . |.| | .|| |...  .||.. . .   ..
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 388-647 2.7e-37 123.1 In-house 19-293 (301) alignment 
Range on Protein: 388-647
Range on HMM: 19-293/301.0
AQFDQLYRKKPGMTMGACRlAENVAKNRYRDIAPYDATRVILREADTGDYINANTINMD-IPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLT
.|...|.....  ..  ..  || | ||...|..||  |.||..  . |  . . ||   | |.   .|..|||||. .|. ||| ..|... . |||.|
eqykelkegedksctvgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

TNVERGRVKCHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAYRDFII--CNT-------------ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRV
   |. . ||..|||. . . .    ..|  .     |.|  |.. .   ..             ..|. . |||.| . ||..||  .    |  .  |
nlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddv

--RQCRVGmDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIiRVYM
  || ..|   | .||||....|.|| .... ..    |.  |   ..... | ..|  ..|  || .. ..|   |.
ihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi.dmyl
DSPc_SM00195 389-646 4.8e-80 264.0 In-house 5-262 (263) alignment 
Range on Protein: 389-646
Range on HMM: 5-262/263.0
QFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVML
.|..| ....  ..   .  .|..||||..| ||| |||.| . .   . |||||| |...    .  .||.|.|||||.||.||| ||||.....||||
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTNVERGRVKCHKYWPDL-DDRLKFGpDLEVRCTRCDETP-SFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTI
| ..|.|. ||..|||.  ..  .|| ...| ........ ..  |.. . .....|.| | |.|| .||||||||. ...|...  |....   ..|..
teeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
||||||.||||...|.....  .|... |   .||.  |.|||...|| .||.|..|||....
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 389-646 4.8e-80 264.0 In-house 5-262 (263) alignment 
Range on Protein: 389-646
Range on HMM: 5-262/263.0
QFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVML
.|..| ....  ..   .  .|..||||..| ||| |||.| . .   . |||||| |...    .  .||.|.|||||.||.||| ||||.....||||
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTNVERGRVKCHKYWPDL-DDRLKFGpDLEVRCTRCDETP-SFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTI
| ..|.|. ||..|||.  ..  .|| ...| ........ ..  |.. . .....|.| | |.|| .||||||||. ...|...  |....   ..|..
teeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
||||||.||||...|.....  .|... |   .||.  |.|||...|| .||.|..|||....
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 389-647 1.5e-36 120.7 In-house 27-288 (305) alignment 
Range on Protein: 389-647
Range on HMM: 27-288/305.0
QFDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADTGDYINANTINMdiPGfdLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTN
.|  . | .    | | . |..  ||||.|.   |  || |. .   .|| || .    |     .... .| || .|  ||||| ....   | ||   
efvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvst..pt..npkrfictqaplektcadfwymclqdkveaifmlcnl

VERGRVKCHKYWPDLD-DRLKFGPDLEVRCTRCDETPSFAY---------RDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRvgm
.|.|  ||..|..  | | |.|  . .    ... . .. .         .  .. . . .. | | .  .. ||| |||      |... . |  .   
lekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk...

dVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPL-DIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
  |..||||||||||| .. .|  .  . | . .     |..  |.||   ||| ||| || . |.  . 
.gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_PTPN6_pd Subfamily PTPN6 390-647 7e-74 243.6 In-house 32-297 (306) alignment 
Range on Protein: 390-647
Range on HMM: 32-297/306.0
FDQLYRK--KPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADT-G-DYINANTINMDIPGFDlvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVML
|..| ..  |  ..    . .||  ||||. | |.| |||||.| .. | |||||| |. ...| |  ..|.|.|| |..||.||| |||.. |..|||.
feelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd..ksyiatqgclettvsdFWrmvwqensrvivmt

TTNVERGRVKCHKYWPDLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICN-TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMD----V
|..||||. || .||||  .. ..| ...|.... ... .. .|.. ... .  |||| | |... .||||||| | . .|||.  |.. .  .      
tkevErgkekCarYWPdeeekeeyG.kisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeag

PTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDI---VRTERDQRPMLIQTAAQYKFVCEAIiRVYM
|..||||||||||| .| ... . ||| .   ...||   |.. |.||  |.||..||||| .|| . |.
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai.kkyi
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 390-646 3.5e-55 182.2 In-house 26-279 (315) alignment 
Range on Protein: 390-646
Range on HMM: 26-279/315.0
FDQLYRKKPGMTMG---ACRLAENVAKNRYRDIAPYDATRVIL--READ-TGDYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIV
| | |   ||  .      .  ||. |||| .| .|| .|| |   | |   ||.|||     |.|..  ..|.|||||....|.||| .|.|.  . ||
fkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanf....idGynkkrryiaaqgpnvasvkdfwrlvfeedigkiv

MLTTNVERGRVKCHKYWPDLddRLKFGPdleVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTI
|||  ||. . |. |||||   .. .|.   .  || .|     |    .  .  .. | |.|..| .||| |||  .  ..... .|.| .     . .
mltnlvegekrkaekywpdk..kviyGk...itvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaiv

VHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
||||||.|||| .||... .  .||.. .   ....  |..|  ..|.|.||.|. .|..  .
vhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 390-648 7.5e-49 161.1 In-house 26-284 (290) alignment 
Range on Protein: 390-648
Range on HMM: 26-284/290.0
FDQLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILR----EAD-TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVM
| .|   .   |.      .|  .||...| .||  |..||    . | | .||||  |.    |.   ..|.|.|||..||. ||| ..|....| |||
fkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik....gykekkqyiatqgpvsntlvdFWkliwqekvtiivm

LTTNVERGRVKCHKYWPDLDDRLkFGPdLEVRCTRCDETPSFAYRDFIICNTAT-KEERIVLQMQYVAWPDHG-VPDDSSDFLDFVLRVRQCRVGMDVPT
||. .| |.|||..|||| | .  .|.  ... .   .. ..  | . . |. . .....| | |  .|...| |.. ..  | .  .... |   . . 
ltniieegkvkCqqYWpdsdtka.yge.fsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsi

IVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRvYMD
.||||...||..|.....|..   . .  .  ...... | |.| ..||. ||..... ... |.|
vvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt.yld
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 390-644 1.7e-47 156.9 In-house 26-277 (439) alignment 
Range on Protein: 390-644
Range on HMM: 26-277/439.0
FDQLYRKKPGMTMGACRLAEN--VAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVM
|...   .|  .  |. .|..   .||||.|....| |||.|.|        ||||| |.    |.   . |.|.|||  .|..||| .|.|.... |||
fekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyik....Gyyddklyiatqgpkkettddfwrlviekktvtivm

LTTNVErgrvkCHKYWPDlDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNT--ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMD-VP
||  ||      .||||  |.   .| |. ||. |  | | .. | | . |    |. || |||..|.||||. || ..|  |||.  .  .    .  |
ltnlve.....sykywps.daevcyg.diavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygp

TIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
 .||||||.|||| .|... |.  . ... |    ||.  |.||  ..|. .|| |. .|.. 
vvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_eak_pd Subfamily eak 391-568 4.8e-19 62.9 In-house 33-204 (332) alignment 
Range on Protein: 391-568
Range on HMM: 33-204/332.0
DQLYRKKPGMTMGACRLAENVAKNrYRDIAPYDATRVILREAD--TGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTN
 .| .... ...   .  |.| .|   .| |||   | |  .      ||||  ...     .. .||. .  .  . |  || || ||.|  ||.|  .
adlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefs....evGrkyiltGiasedkvfafwqmvleqkspaivqlled

VERGRVKCHKYWPDLD-DRLKFGpDLEVRCTRCDETPSFAYRDFIICNtaTKEERIVLQMQYVAWPDHGVPDdSSDFLDFV
|| .  |  ||.||   . ||||  |.| .    .   . .| ...      |   ||  ..  | .  .|    ||| . 
velkleksdkyfpdktreelkfG.ildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpk.yedflalr
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 392-648 8.6e-47 154.8 In-house 30-290 (325) alignment 
Range on Protein: 392-648
Range on HMM: 30-290/325.0
QLYRKKPGMTMGACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTINMDIPgfdlVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMlTTN
.|   . |... .  . ||.||||.... ..| .||.|   ...   |||||. .. |.      . ..||| ||..|.||.| .| . |....|. .  
gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkk....kdvflaaqaPltatindlWrlvldWrcsvvvv.lne

VERGRVKCHKYWPDL-DDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDF---VLRVRQCRVG---MDVP
.. |  .| .|||.   .  .||. |||.    .|   . .| . . ..   | | | |.|. .|.| ||.   . .. .   |  | ..         |
ldlgkdrcavywpkemgksktfGg.levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastp

TIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMD
 .||||||.|||||.|.. .|.  .  .  |  .. |.  | .|| ...|. || .. ||.. .|| 
ilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_PTPRD_pd Subfamily PTPRD 395-655 1.1e-84 280.1 In-house 33-289 (564) alignment 
Range on Protein: 395-655
Range on HMM: 33-289/564.0
RKKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREA---DTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVER
.... .|. |..  .| ||||| .| .||..||.|..    .  |||||. |.    |..  ..|.|.||||..|..||| |||||.|. |||||  .|.
eegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEk

GRVKCHKYWPDLDdRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIG
|.||||||||. . . ..| .|.|  . . |   .  |.|.. .. ..| | | | ....|||||||.   ..||.. .||...     |..||||||.|
gkvkchkYWPekg.tetyg.eltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVG

RTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRvYMDCIVKPID
|||. |...  .  |.... |    .|.. | ||....||  || |. |||   ...| .. ..
RTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaile.alacgnteve
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 396-644 9.4e-58 191.0 In-house 47-289 (319) alignment 
Range on Protein: 396-644
Range on HMM: 47-289/319.0
KKPGMTMGACRLAENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTtnverg
  .. ..  . | .|  |||. .| ..| ..| |.  .     |||||  ..    |.   .||.||||||.||..||| |.||.... ||.||      
gvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvt....GyqrkdkyiaaqGPldntladfWrmiweyncstivllt......

RVKCHKYWPDLDDRlKFGpDLEVRCTRCDETPSFAYRDFIICN-TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDV--PTIVHCSAG
. || .|||   .  | .   .|. .  .||  .. ||. . . .  |. | . |  .  |||.|||| .||.. .| .||  .  ..   . .||||||
kdkcsqywplkivi.kee.rfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaG

IGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
.||||| |.... .  .. .. |   ..||  |.||. |.|  .||||.  |.. 
vGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 396-650 6.8e-50 164.6 In-house 35-281 (287) alignment 
Range on Protein: 396-650
Range on HMM: 35-281/287.0
KKPGMTMGACrlAENVAKNRYRDIAPYDATRVILREAdTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVK
..  .|..     .|  |||...| ..|  ||.|..    |||||  |.    |.   .....|..|. ||. .|| ...... | ||||. . |  . .
redevthnia..sqnkdknRltqilvpdnyrvllkge.hpdyinavfid....gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeev

CHKYWPDLDDrLKFGPdLEVRCTRCDETPSFAYRDFIICNTA-TKEERIVLQMQYVAWPDHG-VPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRT
|..|||. .  . .|.  ... .  . . ..  |.. . |.  ..... | | |. .|...| |..  . .| .  .... |   . . .||||...||.
cyqyWpeeks.vvlGe.yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrs

GVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIiRVYMDCI
.... ..|..   . .  .  .....  | |.|  .||..||||.....  .|.|. 
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindiv.leyldsf
subfamily_PTPRG_pd Subfamily PTPRG 397-644 5.8e-60 198.1 In-house 34-285 (563) alignment 
Range on Protein: 397-644
Range on HMM: 34-285/563.0
KPGMTMGACRLAENVAKNRYRDIAPYDATRVILREADT----GDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERG
.  ... . .  ||  |||| .| .|| .|| |..        |||||| |.    |.   ....|.||||..|..||| |.|||....|||.|  ||||
skdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid....GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlverg

RVKCHKYWPDlDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTAT---K---EERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHC
| ||. |||  |. ...|  |.|. .. . . . . | ..| |.     |   .|. | | .|  |||||||. |   | || .  . .     |..|||
rrkcdvYWPk.desetyg.alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHc

SAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
|||.||||..| ..| .  |.... |  ...... | ||..|.||  || |. .|.. 
saGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 397-644 4.2e-57 188.8 In-house 12-253 (284) alignment 
Range on Protein: 397-644
Range on HMM: 12-253/284.0
KPGMTMGACRLAENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTtnvergR
 .| ..  . | .|  |||. .| ..| ..| |.  .     |||||  |.    |.   .||.|.||||.||..||| |.||.... ||.||      .
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfit....GyqrkdkyiatqGPldntladfWrmiweyncstivllt......k

VKCHKYWPDLDDRlKFGpDLEVRCTRCDETPSFAYRDFIICN-TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDV--PTIVHCSAGI
 || .|||   .  | .   .|. .  .|.  .. ||. . . .  |. | . |. .  |||.|||| .||.. .| .||  .  ..   . .||||||.
dkcsqywplkivi.kee.rfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagv

GRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
||||| |.... .  .. .. |   ..||  |.||. |.|  .||||.  |.. 
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPRA_pd Subfamily PTPRA 398-647 7e-65 214.1 In-house 46-296 (330) alignment 
Range on Protein: 398-647
Range on HMM: 46-296/330.0
PGMTMGACRLAENVAKNRYRDIAPYDATRVILREA---DTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRV
   |. ..   ||  |||. .| ||| .|||| .    .. |||||  |.    |.   .|..|||||. .||.||| |.|||.|. |||||   || . 
iqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid....GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkee

KCHKYWPDlDDRLKFGpDLEVRCTRCDETPSFAYRDFIIC----NTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGI
||..|||| .  . .| .. |    . .. ... |.|..     .|  |..|.| |. . .||| ||| ..   |... .|....  .  | .||||||.
kcaqywPd.eGlvtyG.nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGv

GRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
|||| .|.... .  ..|.. |   ..|.  | ||| ..||  ||.|. ...   |.
GrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 399-649 4.9e-62 204.9 In-house 45-292 (298) alignment 
Range on Protein: 399-649
Range on HMM: 45-292/298.0
GMTMGACRLAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVK
  .. . |  ||  |||| || ..| .||.|..    . .|||||  ..    ...  | ..|.|.||..||.||| ||.|. .. |||||. .| ...|
eeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh....aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktk

CHKYWPDLDDRlKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMD-VPTIVHCSAGIGRTG
.||||||   . ..| ...|.  . .|   .. | ... .. ...|| | |.... |||.|||  ..  ||.. .||. .     .| ||.||||.||.|
yhkywPdegke.tyg.eitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsG

VLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRvYMDC
  | ... .  ..... |  ...|.. | .|| ..|| .||.|. ||... ..|.
tfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle.alds
subfamily_PTPRN_pd Subfamily PTPRN 400-643 6e-51 167.9 In-house 46-289 (297) alignment 
Range on Protein: 400-643
Range on HMM: 46-289/297.0
MTMGACRLAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINMDIPGfdlVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKC
 |  ...  .|| |||.... ||| .|| |.|   |.. ||||| .|  . |       |.|.||||..|| ||| ||||| ...||.||.  | |  .|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpr...apayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

HKYWPDLDDRLKFGPDLEV--RCTRCDEtpsFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTG
..||||    .    ....      ||.   .  | | . |  |.| | | |. ...||..|||  .  .|.|  .| ..  |   | .||||.| ||||
krywpdeGsevyhiyevhlvsehiwcdd...ylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtG

VLITMEtaMCLIEANEPVYPLDIVRT---ERDQRPMLIQTAAQYKFVCEAII
| | ..  . |   .  |  .||. |    ||||| |..| .|..|.  |..
vyilid..lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
0049772 (Phosphotyrosine protein) phosphatases II 400-642 3.7e-36 120.8 In-house 36-276 (314) alignment 
Range on Protein: 400-642
Range on HMM: 36-276/314.0
MTMGACRLAENVAKNRYRDIAPYDaTRVIL--READTGDYINANTINMDipgfdlvNKYVAAQGPLPNTVNDF----------WYMV--WEQRSTLIVM-
.|. ...| .|  |||| || |.| .||||   . .. |||||. ..         .|..|.||||..||.||          | ||  .....  ||| 
ltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------LTTNVERGRVKCHKYWPDLDdrlkfgpdlevrcTRCDETPSFayrdfiicntatkeERIVLQMQYVAWPDHGVPdDSSDF
                    |..  ..|   . .....|              ..... . |              || ...  .. .||...| ...||
rdevladelsrLdaAlgKtpllildgngneptaadlellk.............eelydpelf..............erlgikylripvpDgsap.lledf

LDFVLRVRQCrvGMDVPTIVHCSAGIGRTGVLITmeTAMCLIEAnePVYPLDIVRTERDQRP-----MLIQTAAQYKFVCEAI
..|.  ....    . |..|||.||.||||....  .|....     | . ....  | .||      .|..  || |. ||.
deflefieea..dkggpvlvHCkaGkgRtgtfvv..aaylmkll..gvsleealedvrlkRpinpnpgfieqleqyefileal
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 400-461 6.9e-10 33.0 In-house 34-95 (95) alignment 
Range on Protein: 400-461
Range on HMM: 34-95/95.0
MTMGACR----LAENVAKNRYRDIAPYDATRVILREADTGDYINANTINmdipGFDLVNKYVAAQG
|| ||         |. |||. .| |||||||.|      |||||  ..    |.   | |.||||
mtsgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvd....gyarkncyiaaqg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 401-646 1.7e-69 229.1 In-house 38-279 (288) alignment 
Range on Protein: 401-646
Range on HMM: 38-279/288.0
TMGACRLAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCH
.  | |||.|  |||||.| ||| .|| |..    .. |||||. |. .    .  .||.|.||||..|||||| .|.|.... |||||  ||.|. ||.
svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge....kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCe

KYWPDLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICntATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLI
.|||| |.  ..| ...|  .   |. .|  | ...    .|.|. . |.|| ||||||||... ..|...  | .       | |||||||.||||. |
eYWPdadkpknyG.svtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFi

TMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
......  .|... .  ...|   | ||..|.||  || |. |... . 
aldalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN1_pd Subfamily PTPN1 401-644 3.2e-64 211.4 In-house 23-269 (290) alignment 
Range on Protein: 401-644
Range on HMM: 23-269/290.0
TMGACRLAENVAKNRYRDIAPYDATRVILREADTgDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYW
.. ...| || ..|||||. ||| .|..|..||. |||||. ....    ..  .|. .||||||||. || |||||.|  .|||   ||....||..||
ptreaklpenrnlnryrdvspydhsrikleradn.dyinaslvele....eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PDLDD--RLKFG-PDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVG-M-DVPTIVHCSAGIGRTGV
|  ..   |..    |.|.  . ...  .  | . . |  |.| | .|.. |..||| |||.  . ||.|. .||.. .      |...||||||||.| 
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

LITMETAMCLIEANEPVYPLDIVR---TERDQRPMLIQTAAQYKFVCEAIIR
.. ..| . |||... .  .|| .     | .|  ||||| | .|   ||. 
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 402-644 2.3e-56 185.9 In-house 36-275 (315) alignment 
Range on Protein: 402-644
Range on HMM: 36-275/315.0
MGACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHK
  ..|  .|  ||||..| |.| .||.|    .    |||||      |...|  . |.|.||||. .|.||| ||.... | |||.|   |  ..|| .
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasy....iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPD-LDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNtaTKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLI
||||   |  .||  ..|     . .     | ... .  ..| | | | |.  |||.||. ..| .| ..  |.  .   . . .||||||.|||||.|
ywPdrkadsvefG.sikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvi

TMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
...  .  |. .. |  ...|.. |..|| |.||  .| |. .|.  
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 403-638 6.4e-28 92.2 In-house 30-261 (281) alignment 
Range on Protein: 403-638
Range on HMM: 30-261/281.0
GACRLAENVAKNRYRDIAPYDATRVILRE----ADTGDYINANTINMDIpgfdLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHK
 .     |  |||| .|   | .|| |.      .. ||| || |   .    |   |. .|||  .|  ||| |.|.. .| ||||   .|  | || .
tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf....lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcae

YWPDLDD-RLKFGpDLEVRCTrcDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRqCRvgmDVPTIVHCSAGIGRTGVLI
|.|      |.|   | |     | |   .     .  .   | |.. .  .  |||  ||. |  .|  . ..| .|     | ..|||||.||.| |.
yfprnahcclqfd.klsvsye..dstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir.ar...stppvihcsagvgrsgtlm

TMETAMCLIEANEPVYPL-DIVRTER-DQRPMLIQTAAQYKFV
..| |.  | .   .  . .||   |   |   .||  || ..
aveialqsihshftlpdikqivshlrvtgraasvqtlqqymli
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 403-642 1.7e-26 87.8 In-house 25-255 (267) alignment 
Range on Protein: 403-642
Range on HMM: 25-255/267.0
GACRLAE-NVAKNRYRDIAPYDATRVILREAdTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTnVERGRVKchKYWP
 .. .|| | ..||. |  ||| ||||||.  . .||||  ..    |.   |.... |.|| ||. ||. .. .|. . ||.||. |  . ..  ..||
isqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyve....gyktknafivtqdplkntitdfltvihdqkvpvivlltk.vftdnir..lfwP

DLDDRLKFGPDLEVRCTRCDETPSFAyrdFIICNTATKEER--IVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGmDVPTIVHCSAGIGRTGVLITM
    . |   || |  .   |   .     |  .   |.|    |    |  |            |  .|   |   | . | .|.||.|.||.| ....
Pkmgqakkyqdltvehslekeendyq...iitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqleng.nrPlvvacsdGvGrsGtflvi

ETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAI
.. .  .  .. .   | .|  |.||. |..|  .| .. | .
dsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
0040439 (Phosphotyrosine protein) phosphatases II 404-645 2.3e-72 238.9 In-house 5-245 (249) alignment 
Range on Protein: 404-645
Range on HMM: 5-245/249.0
ACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYW
 ..| ||. ||||.|| ||| .||.|   ..   .|||||. |    .|..  ....|.|||||.||.||| |.||...| |||||. ||.||.||..||
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PDlDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV--GMDVPTIVHCSAGIGRTGVLIT
|. .. |..|  . |....... ...  | . . |. ..|.| ||..||. |||||||.. .|.|||. .||...   . . |..||||||.||||..|.
pl.ggsleygd.ftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

METAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRV
. ......| .  | ....|.. |.|||. .|.  ||.|..||... 
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPRK_pd Subfamily PTPRK 404-644 1.7e-62 206.1 In-house 37-275 (314) alignment 
Range on Protein: 404-644
Range on HMM: 37-275/314.0
ACRLAENVAKNRYRDIAPYDATRVILREADTG---DYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYW
|..  || .|||. || .|| .||.|   |     |||||. |     ..   ......||||..||.||| .|...... |||||  || ||||| |||
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaali....dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW

PDLDDRlkFGpDLEVRCTRCDETPSFAYRDFIICN--TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLIT
|.  .   .| |..| . ...    .  | | ...   . .| |.| |.|...||||.||     .|..| || . .   . ...|||||| ||||. |.
Pedtev..yg.dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfia

METAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
... . .|| .. |    .|.| |.... ...|  ||||. ..|. 
idivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 404-646 2.7e-58 192.0 In-house 32-277 (287) alignment 
Range on Protein: 404-646
Range on HMM: 32-277/287.0
ACRLAENVAKNRYRDIAPYDATRVILR-EADTG-DYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP
|     .| |||| |. |.| |||.|  |.. | ||||||     ....   ....|||||.. ||.||| .|.|.||. ....| .|| .| ||.||||
aaeelaavkknryadvlPiddtrvllsaegelGsdyinany....vasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

DLDDRLKFGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRV----RQCRVGMDV-PTIVHCSAGIGRTGVL
. .  .. |    |   .    | .. | . . .  |.| |.| |.....|||....  .  .. ||| |       | . .| | .||...||||.|.|
erevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil

ITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
... . .   |    | .  .|   | .|  |.|.. |.....||..  |
latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 404-644 4.4e-41 135.6 In-house 39-234 (392) alignment 
Range on Protein: 404-644
Range on HMM: 39-234/392.0
ACRLAENVAKNRYRDIAPYDATRVIL---READTGDYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGrvkchkyw
...   |. ||||..| |||..||.|    .    ||.||      ||.||  . |.|.||| . ...||| ||.... | |.|.|   |          
vaqkeinlkknryknilpydsarvkleviddipdsdylnasy....ipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........

pdlddrlkfgpdlevrctrcdetpsfayrdfiicntATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITME
                                      .. | | | ... |||..||  .| .| |.  |.        | |.|||||.|||||.|...
....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisid

TAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
. ..  .    |  ...|   | .||...||  || |.  |.. 
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 404-444 4.3e-06 20.5 In-house 33-75 (244) alignment 
Range on Protein: 404-444
Range on HMM: 33-75/244.0
ACRLAENVAKNRYRDIAPYDATRVILREA--DTGDYINANTIN
 . |. |..|||| .| |.| |||||  .  .  |||||| |.
navlsanatknryinilpfdetrvilssskkegsdyinanyiq
0042113 (Phosphotyrosine protein) phosphatases II 405-643 3.4e-73 241.4 In-house 4-240 (245) alignment 
Range on Protein: 405-643
Range on HMM: 4-240/245.0
CRLAENVAKNRYRDIAPYDATRVILREADT---GDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP
..| ||. ||||.|| ||| |||.| . ..    |||||. .    .|..  .|. |.|||||.||.||| |.||...| |||||. .|.|||||..|||
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

DlDDRLKFGPdLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV-GMDVPTIVHCSAGIGRTGVLITME
. .. |..|  . |......  ...  | . . |. ..|.| |....|. ||||||||.....|||. .||...  . . |..||||||.||||..|.. 
l.gesltygd.ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

TAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
......|..  | . ..|.  |.|||. .||  ||.|. ||..
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 405-643 1.6e-67 222.9 In-house 5-239 (243) alignment 
Range on Protein: 405-643
Range on HMM: 5-239/243.0
CRLAENVAKNRYRDIAPYDATRVILreaDTGDYINANTINMDiPgfdlvnKYVAAQGPLPNTVND----FWYMVWEQRSTLIVMLTTNVERGRVKCHKYW
..| ||. ||||.|| ||| .||.|   . .|||||| |..  |      .. | |||||.||.|    || |.||...| |||||. ||.||.||..||
allpenlsknrysdilpydhsrvkl...egsdyinanliyvt.p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PdlDDRlKFGPdLEVRCTRCDETPSFAYRDFIICNTA-TKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQC--------RVGMDVPTIVHCSAGIG
|  ..   .|. ..|... . ..... .| . ..|.  ....| | . .|..||||||||. .|.|||.  ||..            . |..||||||.|
p..gev.tygd.ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGVLITMETAMCLIeanePVYPLDIVRTERDQRPM-LIQTAAQYKFVCEAII
|||.||.. . . |.     | ....|.. |.|||.  .||  ||.|. ||..
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 405-648 6e-59 194.4 In-house 23-269 (274) alignment 
Range on Protein: 405-648
Range on HMM: 23-269/274.0
CRLAENVAKNRYRDIAPYDATRVILR----EADTGDYINANTINmdipGFDLVNK-YVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKY
 ... .  ||||..| | . .||.|.    |..  .||||| |     |.| ..| |||.||||||||.||| |........|||||   |. . ||..|
ldvfgsqtknryktilPnensrvllesessededssyinanyik....GydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPDLDDR---LKFGpDLEVRCTRCDETPSFAYRDFIICNTATkeERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVP---TIVHCSAGIGRT
.||  |     ..| |.|.. .   |.  .  | ... ..    || |  . | .|||| .||| . .||.|| |.. |   . .   ..||||||||||
fPdaedyeiseryg.dveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIrVYMD
|. |... |.  ..... |  | ||   | .|  ..||. ||... .|..  |. 
GcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc.lylk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 406-643 2.9e-42 139.5 In-house 29-263 (283) alignment 
Range on Protein: 406-643
Range on HMM: 29-263/283.0
RLAENVAKNRYRDIAPYDATRVILREADTgDYINANTINMDIpGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDlDD
   ||  |||...| |.|  || |.     |||||  | ..    .  .||..||.|| .|| ||| ||.... | |||||   |  |.|| .|||  . 
sadenkrknrnqeivpadqwrvelksesr.dyinavfipvsk.sykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk.rG

RLKFGPdLEVRCTRCDETPSFAYRDFIICNT-ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMC
  ..|. . |   .     ||  . ... .  ..|.. ..   |.. | . |       .. | . . . .   . | .||||.|||||.|.|.. ... 
sedyGe.ftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvk

LIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 . ..  |    .|.  | ||.|..||  |||.| |...
daltesvvdvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 406-485 4.7e-10 33.5 In-house 33-116 (347) alignment 
Range on Protein: 406-485
Range on HMM: 33-116/347.0
RLAENVAKNRYRDIAPYDATRVILRE--------ADTGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVML
    ...||| .|    |||||.|           |.  ||||  |..|    .  ..|. .| |||.|| ||| ||   . | .| .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfd....naskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 407-644 2.3e-58 192.3 In-house 17-262 (270) alignment 
Range on Protein: 407-644
Range on HMM: 17-262/270.0
LAENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipGFDLV-NKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPD
 | . . |||.|| |  ||||.| |    ..  ||||| ..    |||   .||.||.||||.|...|| |.||...| |||.|  .|.|| || .||| 
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvr....GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa

LDDRLKFGPDLEVRCTRCDETPSFAYRDFII-CNTATKEERIVlQMQYVAWPDHGVPDDSS------DFLDFVLRVRQCRVGMDV--PTIVHCSAGIGRT
  ..     | ... . . |. .  |.   .  ..  .|.|.|   .|..||||||| ..       . |  .  ||. .  .|   |..||||||.|||
epkekvkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

GVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
|.||....|..|.| .. | .| |..  | .|. |.|.  ||.|. .|.. 
GtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 408-649 1.2e-54 180.1 In-house 7-244 (250) alignment 
Range on Protein: 408-649
Range on HMM: 7-244/250.0
AENVAKNRYRDIAPYDATRVILREAD---TGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVkCHKYWPdLD
 .|  |||| || ..| .||.| . .     |||||  ..    |.|  . ..|.||||..|..||| ||.|. |. |||||. .| ... .|.|||  .
pqnkeknryadiialdssrvvLekekgdkesdyinasflh....gyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.ve

DRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVG-MDVPTIVHCSAGIGRTGVLITMETAM
   |.| |. |     .|   .  | ... ..  ..|||| |...|.||| |||.     |... .|.. .    . | ||.||||.||.|  |.... .
kaekyG.dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

CLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRvYMDC
  .. .. |   ..... | .||  ... .|| || |.|.. ..|.
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk.alds
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 408-644 1.2e-54 180.5 In-house 46-282 (297) alignment 
Range on Protein: 408-644
Range on HMM: 46-282/297.0
AE---NVAKNRYRDIAPYDATRVILREADTG---DYINANTInmdiPGFDLvnKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRvKCHKYWP
||   |  |.||..| |||  ||.|.  ..    ||.||  .    .|.    .... | | ..||.||| ||.... . ||||. . || . || .||.
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv....kgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

DLDdRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPD--DSSDFLDFVLRVRQCRVGMDV-PTIVHCSAGIGRTGVLIT
|     .|| |. |  .  .|   |  |.. . . ..| .|.| | |.| |||. |.   . | .|...  ||.   .    | .|||.||.||||||.|
dkg.vttfG.dvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

METAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIR
..  .. .. .. |  ...|.  |..|| |.||  ||||| .|.. 
idsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavle
subfamily_egg_pd Subfamily egg 408-650 4.8e-30 99.3 In-house 38-274 (307) alignment 
Range on Protein: 408-650
Range on HMM: 38-274/307.0
AENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERgrVKCHKYWPDL-
..|  | | . .   | .|| |.      ..|.| || ..    |  |.|... || || |||.||| ||....   |||||...|    .|. |||   
dnnlekarskrvhckdssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

DDRLKF-GPDLEVRCTRCDETPS--FAYRDFIIcNTATKEERIVLQMQYvawpDHgvpDDSSDFLdFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITME
.| |..    |.. . . |...   |    . .   . .||| .   |.    |    . |||   . ||| .    .  |..|..  |. ....|...|
sdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg....dv...nnssdvy.splrvlrklrnlskpvvvqdilGvskaatlvaie

TAMCLIEANePVYPLDIVRT---ERDQRPMLIQTAAQYKFVCEAIIRVYMDCI
.|.. .    |..   . |.    | .|.. .... .| ||   .. .. | |
iallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi
subfamily_PTPN23_pd Subfamily PTPN23 409-644 4.3e-62 204.5 In-house 42-278 (288) alignment 
Range on Protein: 409-644
Range on HMM: 42-278/288.0
ENVAKNRYRDIAPYDATRVILReADTGDYINANTINMDIPGfdlVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLK
 .. |||.||| ||| .|| ||   . |||||  ..   ||     ...|.|.||..|.|||| ||.||.| .||||... |.|. |...|||   .. .
lyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspg...cPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

FGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQ----CRVGMDVPTIVHCSAGIGRTGVLITMETAMC
  .||.| . .  ||. .  |....    ... . |  .|. .||..|||.  ...|.|.  |..     .  ...| .||||||.|||||.  . .|. 
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

LIEANEPVYP-LDIVRTERDQRPMLIQTAAQYKFVCEAIIR
 .|... .   ...|.. | ||   .|. .|.||. ||...
elekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 409-643 5e-53 174.8 In-house 2-236 (237) alignment 
Range on Protein: 409-643
Range on HMM: 2-236/237.0
ENVAKNRYRDIAPYDATRVILREADT-GDYINANTINmdipGFDLV-NKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDR
|| .|||| .|  || .||.|. | .  |||||. ..    |||   .||.|||||| .. .||| |||... ..|||||  .|. ..|||||||. |. 
enkiknrygnivaydhsrvvlkgagsgsdyinatylk....gfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

LKFGpDLEVRCTRCDETPSFAYRDFIICNTAT-KEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRV--RQCRVGMDVPTIVHCSAGIGRTGVLITMETAM
  .|  | |  .. .|   .. | ... .  | || |.. | |. .|||.|||. .. .| |  ..  |   |    | |.|||||.||||... ... .
aayg.vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

CLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
   . .. |   . | .  ..|| .|||  || |. ..|.
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 409-645 2e-44 146.4 In-house 53-282 (290) alignment 
Range on Protein: 409-645
Range on HMM: 53-282/290.0
ENV--AKNRYRDIAPYDATRVILREADTGDYINANTINmdipGfdLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDD-
.|    ||||.|..  | |||||..   |||. || ..    |  |   .. .||.| .|| |.| || ... . ||||   .| |. ||..|.|. .  
kntefkknrykdvvcndktrvilkdGydGdyvhanyvk....G..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

RLKFGpDLEVRCTRCDETPS-FAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQcrvgMDVPTIVHCSAGIGRTGVLITMETAMC
 | || .. | |.  |.  .    . . . .  .  | ..  .. ..|||. |.  .  .|  .  .|.    .  | .||||||||||| ....|... 
vltfG.eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asGpvvvhcsaGiGrtGtfvaievglq

LIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRV
..     . .||.||. |. |   .|   ||  . |... .
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 409-643 2.5e-43 142.9 In-house 6-237 (239) alignment 
Range on Protein: 409-643
Range on HMM: 6-237/239.0
ENVAKNRYRDIAPYDATRVILREA---DTGDYINANTINmDIPGFDlvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDD
 | ||||| .|  || .||.| .       |||||. .  |  |    . |.|.|| .  .  ||| |.|..|  .|||||  .|  . |||.||||   
vnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgsp..kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

rlKFgPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCL
  |.  .| |   . .    .  | |.. .    ||| | | ..  |||.|||. ..  | .  .. .  .    | ..|||||.|||| .. ... .  
..ky.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 . .. |  .. |.. |..|| ..||. || |.  |..
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 409-642 2.7e-43 142.9 In-house 7-237 (239) alignment 
Range on Protein: 409-642
Range on HMM: 7-237/239.0
ENVAKNRYRDIAPYDATRVILREA---DTGDYINANTINmDIPGFDlvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDD
 | ||||| .|  || .||.| .       |||||. .  |  |    . |.|.|| .  .  ||| |.|..|  .|||||  .|  . |||.||||   
vnkaknryanivtydhsrvvleklsndphsdyinasylr.dydgsp..kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

rlKFgPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCL
  |.  .| |   . .    .  | |.. .    ||| | | ..  |||.|||. ..  | .  .. .  .    | ..|||||.|||| .. ... .  
..ky.cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAI
 . .. |  .. |.. |..|| ..||. || |.  |.
akkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_ptpA1_pd Subfamily ptpA1 409-603 4.6e-37 122.7 In-house 46-253 (418) alignment 
Range on Protein: 409-603
Range on HMM: 46-253/418.0
ENVAKNRYRDIAPYDATRVILRE---ADTGDYINANTINMDIPgfdlvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDD
 | .|||| .| | . ||| |..    .  |||||| |.   |     ......|||||||. ||| ||||.|  .||||. . |  |.|| .|||.   
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.....kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

R---LKFGPDLEVRCTRCDETPS---FAYRDFIICN---TATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVL--RVRQCRV----GMDVPTIVHCSAGI
      .|   ||  |   |         |. |  |   |   | | . | ||  |||| .|| .  | ...     || ..      .|| |||||||.
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRTGVLITMETAM
|||| . |    |
grtgtfctavimm
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 409-646 3e-36 119.8 In-house 34-270 (285) alignment 
Range on Protein: 409-646
Range on HMM: 34-270/285.0
ENVAKNRYRDIAPYDATRVILREADTgDYINANTinMDIPGFDLvNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPD-LDDRL
 |   ||| |.   . |||.|.. |  ||| |.   | .|| |  . |...|||||.|..|||.|..... . ..|| | .| |  ||  |.|. | . .
anpdlnryadvrcieetrvvlknhdr.dyihasw..mrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

KFGpDLEVRCTRCDETP--SFAYRDFIICNT--ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRvGMDVPTIVHCSAGIGRTGVLITMETAM
|||   |.  | | |       .  . . ||  |. |   . ..|   |||.  |.|.  ....   |..     . |  ||||||.|||  .. .. | 
kfg.kyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn.pkekpicvhcsagvgrtatfvgidyat

CLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
  |  |  .  |||||  |  |   .|.  |. |.   ..  .
irimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 409-606 3.5e-28 93.3 In-house 46-289 (350) alignment 
Range on Protein: 409-606
Range on HMM: 46-289/350.0
ENVAKNRYRDIAPYDATRVILR-----------EADTGDYINANTINMDIPGFDLVN--KYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVK
|  |||||..| ||. .||.|.              | |||||| ...  .. .     ||.|.|.|||.||.||. .. .   ..|..||..|| .. |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CHKYWPDL--DD-RLKFGPDLE--------------VRCTRC------DETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVL---
|..||...  ||  .|.    |              |. .        |..    . . .  . |. .  .|.|.|.  |.| ..  .  ..|  .    
cyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkn

-------RVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCLI
                  | .||||||.||||.|.|..  .  .
dliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 409-503 1.4e-15 51.5 In-house 47-156 (349) alignment 
Range on Protein: 409-503
Range on HMM: 47-156/349.0
ENVAKNRYRDIAPYDATRVILREA--------------D---TGDYINANTINmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVER
|  |||||.|| ||. .||.|...              |     |||||| ..  .. ..  .||.| | ||| ||.||. ..  ..  |.. |. . | 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylk..ltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel

GRVKCHKYWPDL
.  ||..|| .|
slekcdiywqel
Y_phosphatase Protein-tyrosine phosphatase 410-643 2.2e-74 245.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 410-643
Range on HMM: 1-234/235.0
NVAKNRYRDIAPYDATRVIL-READTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP-DLDDRL
|  ||||.|| ||| ||| |  . .. ||||||..     |..  .|..|.||||..|..||| |||......|||||...|.||.||..||| . .. |
nkkknRykdilpydktrvklkgsegpsdYInAnyv....kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

KFGPdLEVRCT--RCDETPSFAYRDFIICNTATK-EERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMC
..|  ..|...   .... ... |.. . ..... |.|.| |..| .|||||||......||.. .|.. .   . |..||||||.||||..........
tygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

LIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 .||.| |  |.||.. | |||...|...||.|...||.
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 410-643 2.2e-74 245.2 In-house 1-234 (235) alignment 
Range on Protein: 410-643
Range on HMM: 1-234/235.0
NVAKNRYRDIAPYDATRVIL-READTGDYINANTInmdiPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP-DLDDRL
|  ||||.|| ||| ||| |  . .. ||||||..     |..  .|..|.||||..|..||| |||......|||||...|.||.||..||| . .. |
nkkknRykdilpydktrvklkgsegpsdYInAnyv....kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

KFGPdLEVRCT--RCDETPSFAYRDFIICNTATK-EERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMC
..|  ..|...   .... ... |.. . ..... |.|.| |..| .|||||||......||.. .|.. .   . |..||||||.||||..........
tygd.ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

LIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 .||.| |  |.||.. | |||...|...||.|...||.
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 410-643 1.8e-55 183.0 In-house 43-273 (515) alignment 
Range on Protein: 410-643
Range on HMM: 43-273/515.0
NVAKNRYRDIAPYDATRVIL---READTGDYINANTinmdIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPD-LDD
|  ||||..| ||| .||.|    ..   ||.||      ||.||  . |.|.|||.. .|.||| .|.... | |.|.|   |  ..|| |||||   |
nfkknryknilPydsvrvklevindnPhsdyfnasy....ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

RLKFGpDLEVRCTRCDETPSFAYRDFIICNTATkeERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCL
 .|||  ..|     .       | . .        | | | ..  |||.||| ..| .| ..  |.  .  .  | |.|||||.|||||.|...  .  
svkfG.sikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvah

IEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
..  . |  ...|.  |..|| |.||  || |. .|. 
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl
0041856 (Phosphotyrosine protein) phosphatases II 410-643 7.3e-45 148.1 In-house 1-168 (182) alignment 
Range on Protein: 410-643
Range on HMM: 1-168/182.0
NVAKNRYRDIAPYDATRvilreadTGDYINANTINMDIPGFDlvnkYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTtnvergrvkCHKYWPdlddrlkf
|. ||||.|| ||| .|         |||||| . .. |. .    ..|.||||..||.||. |..|.. |.||.||         .. |||        
nldknrysdilpydhsr.......dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

gpdlevrctrcdetpsfayrdfiicntaTKEERIVLQMQYVAWPDHGVPDdSSDFLDFVLRVRQcrvgMDVPTIVHCSAGIGRTGVLITMETAMCLiean
                            ...|| ..| .|. ||||||||  ...|||. .|..     . |..||||||.||||.|. .   ..|    
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....

ePVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
  | . ..|.. | .||. ..|  || |.  |. 
.gvsleeavklvrsrRpgmvitpnqyfflqlall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 410-647 1.3e-39 130.6 In-house 55-290 (305) alignment 
Range on Protein: 410-647
Range on HMM: 55-290/305.0
NVAKNRYRDIAPYDATRVILREADTGDYINANTINMDI-PgfdlVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLD-D--
...||||.|.   | . | | .    ||| || .   . |     .....||||| .|...||.|| ...   ||||   || |..|| .|||    .  
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmip....ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

RLKFGPDLE-VRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRqcrvGMDVPTIVHCSAGIGRTGVLITMETAMC
 || |  .| |  ..  |  .      .  . . ...  | ..|.  ||| |||      |...  .|    |  || .||||||||||| ....|  . 
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair....gskvpivvhcsagigrtgtivaieyile

LIEANEPVYPL-DIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
 |  | |. |. ..|.. |||| . ||.  || |.   ..  ..
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_CG42327_pd Subfamily CG42327 412-574 4.7e-20 66.5 In-house 30-193 (319) alignment 
Range on Protein: 412-574
Range on HMM: 30-193/319.0
AKNRYRDIAPYDATRVILRE---ADTGDYINANTINmdipG-FDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPD---LD
 |.|. .. |   |||.|..    |   |..|. .     |  |  | |.||| .| ..  ||| .||||.|  || ||   | |  .| .|.|    ||
dksrvinvvPlPetrvvlqrigdddkdeyldasyvr....GyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

DRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYvAWPDHGVPDDSSDFLDFVLRVRQC
..  .| |. |     .    .|   ... .   .| | .    |  |.. .|| . . ..  .|.||. 
ntslyG.dilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 413-638 2.6e-28 93.6 In-house 53-273 (301) alignment 
Range on Protein: 413-638
Range on HMM: 53-273/301.0
KNRYRDIAPYDATRVILREADTGDYINANTINMDipgfDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP-DLDDRLKFGP
|.||  .     | | . .  .   | || |. .       ....|.||||.|| .||| |.       ||||. .||.   ||..| | .  ..|. | 
khryptvPckPstavevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

-DLEVRCTRCDETPSFAYRDFIICNTATK-EERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCrvgmDVPTIVHCSAGIGRTGVLITMETAMCLIEAN
 ..... .      .   | . . ... | . | |.  ||. |.|.|||    .  |..  |..     . | .|||||||||.  .|. |     .||.
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteylarevead

EPVYPLDIVRTERDQRPMLIQTAAQYKFV
  .   . ..  |..|   .||  |  ..
ptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 413-645 1.9e-25 84.3 In-house 46-275 (312) alignment 
Range on Protein: 413-645
Range on HMM: 46-275/312.0
KNRYRDIAPYDATRVILReADTGDYINANTINMDIpgfdLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGpD
 ||| .|  .|  |  |   |   || || ...        ...|..|||| ||.  || ..    || |..|.. || |  || ||  |.   ...  |
lnrypniqcwdrgrftla.gdenfyihanfvkict....kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle.d

LEVRCTRCDET-------PSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSsdflDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCL
  |    | |           ..| . .   || .|  . . |. .|||||.||      |  ||.  .      | | |||||.|||| |. .|. .. 
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdsc....dtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaa

IEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRV
.         |.    | .|   ... .|| ..  ... .
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 416-648 2.9e-22 74.1 In-house 24-261 (290) alignment 
Range on Protein: 416-648
Range on HMM: 24-261/290.0
YRDIAPYDATRVILREAD---TGDYINANTINMDiPGFDLVNKY--VAAQ-GPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRV----KCHKYWPDLDD
  ...   ||||.|..     . ||| || . .   |  |.      ..       |...||.|. . ... .|||  . |. .      | || |.  .
RlevpLveatrvvLkgygkrfnddyiHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg

-RLKFGpDLEVRCTRCDETPSFAYRDFIICNTaTKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRqCRvgmDVPTIVHCSAGIGRTGVLITMETAMC
  |||. .|.|.|.   .   .  |  ..     .||  |   ... | .  |..|.  .|. .  |. ..   . | ||||  || |  .| ... .. 
eelkfk.gltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAalaaiilgyQ

LIE-ANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMD
.|   .. |   |.. . | || ..|..| .. ||  .|.   ..
kiaetsgsvkledvlkalrkqralaitsalelafvdagivllaie
0044763 (Phosphotyrosine protein) phosphatases II 421-644 3.2e-29 97.2 In-house 1-169 (178) alignment 
Range on Protein: 421-644
Range on HMM: 1-169/178.0
PYDATRVILREADT---GDYINANTINmdiPGfdlvnKYVAAQGPlpntvNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDrlkfgpdlevrc
|.| |||.| .      .|||||. |    ||      |.....|      |.. ...|.  |.||.||...|.|..||..|||.  .            
pldrtrvllsnleglersdyinaseil...pg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............

trcdetpsfayrdfiicntatkeerivLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCLieanePVYPLDI
                           .|.... .||||||| .. ||.||  .....   . |..||||||.||.|.|. .   ..|      . . ..
...........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleea

VRTERDQRPmLIQTAAQYKFVCEAIIR
..  | .||  ...  |.....|   |
ielvrerRp.ivpnpgqlrqLyefelr
0051429 (Phosphotyrosine protein) phosphatases II 434-646 3.7e-47 156.6 In-house 3-225 (272) alignment 
Range on Protein: 434-646
Range on HMM: 3-225/272.0
TGDYINANTINMDiPGFDLVNKYVAAQGPLPNTVNDFWYMvWEQRSTLIVMLTTNVERGRVKCHKYWP----------DLDDRLKFGPDLEVRCTRCDET
...||||. ...   .  . ... ...||||.|..|||.. .|.. . ||.|.. .||||.||..|||          | ..   .  .| |... .  .
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

PSFAYRDFIICNT-ATKEERIVLQMQYVAWPDHGVPDDSsdFLDFVLRVRQcrvgmDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVY--------P
. . .| ... ..  ..| | |....| .|||||||...  .|...  ...     . | .||||||..|||... .   .  ....  |         .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

LDIVRTERDQRPMLIQTAAQYKFVCEAIIRVY
...|.  |.|||  .|| .||.|..||.. ..
eeaveelraqrpgavqteeqylflyeallell
0043147 (Phosphotyrosine protein) phosphatases II 434-639 2.3e-39 130.2 In-house 4-154 (172) alignment 
Range on Protein: 434-639
Range on HMM: 4-154/172.0
TGDYINANTINMDIpgfdLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNvergrvkchkywpdlddrlkfgpdlevrctrcdetpsfayrdfii
  |||||. ... .      ....| ||||.||..||| |..|.  |.||.||.                                              
gsdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................

CNTATKEERIVLQMQYVAWPDHGVPdDSSDFLDFVLRVRQ-CRVGMDVPTIVHCSAGIGRTGVLITMETAMclieanEPVYPLDIVRTERDQRPMLIQTA
.......|| ..| .|. ||||||| ... .|.|.  ... . .  . |..||||||.||||.|. .   .      . . ....|.. |..||. .|. 
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

AQYKFVC
 ||.|..
sqyrfly
0036282 (Phosphotyrosine protein) phosphatases II 436-639 2.8e-42 139.7 In-house 3-163 (174) alignment 
Range on Protein: 436-639
Range on HMM: 3-163/174.0
DYINANTINMDIPGFdlvnKYVAAQGPLPntvndFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDlddrlkfgpdlevrctrcdetpsfayrdfiicn
|||||. ... .       ...| ||||.     ||.|..|...| .|||.. .|.|..||. |||.                                 
dyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................

TATKEERIVLQMQYVAWPDHGVPDDSSdFLDFVLRVRQCRVG-MDVPTIVHCSAGIGRTGVLITMETAMCLIEaNEPVYPLDIVRTERDQRPMLIQTAAQ
. . .|| ..| .|. ||||||||.|  .|.|| .|....    . |..||||||.||||.|. .   ..... . .|  ||.||. | |||. .||  |
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YKFVC
|.|. 
yrfly
0046846 (Phosphotyrosine protein) phosphatases II 436-644 1.8e-40 133.9 In-house 13-171 (176) alignment 
Range on Protein: 436-644
Range on HMM: 13-171/176.0
DYINANTINMDipgfdlvnKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDlddRLKFGPdlevrctrcdetpsfayrdfiicn
|||||| | ..        ...| |||||.|. ||. |..|.. |..|.||. || ||.||. |||.     |.|                         
dyinanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi........................

tatkeerivlQMQYVAWPDHGVPDDsSDFLDFVLRVRQCRVGmDVPTIVHCSAGIGRTGVLITMEtamcLIEANEPVYPLDIVRTERDQRP-MLIQTAAQ
          | ... ||||||||. ...|...  .|...   . |..|||||||||||.|. .     |.| .  . ....... |.||| . .|| .|
..........qylhlpwpDhgvpdl.elllellefirealke.ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YKFVCEAIIR
|.|. |.. .
yrflyefell
0051082 (Phosphotyrosine protein) phosphatases II 436-640 8.5e-28 92.2 In-house 4-147 (151) alignment 
Range on Protein: 436-640
Range on HMM: 4-147/151.0
DYINANTINmdiPGfdlvnkYVAAQGPLPntvnDFWYMVWEQRSTLIVMLTTNVERGrvKCHKYWPDLDdrlkfgpdlevrctrcdetpsfayrdfiicn
||||.. .    .|      . . .|||.    ||. ...|.  . ||.|.. .|||  .|..|.|.|.                               
dyinfsyvt...gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...............................

tatkeeRIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQcrvgM-DVPTIVHCSAGIGRTGVLITMETAMCLieanepVYPLDIVRTERDQRPMLIQTAAQ
      . ||..... |||.|.|.    .|.|.  ...    . . |..||||||.||||.|. .   ..       | . ....  | .||...|.  |
......ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

YKFVCE
. |.  
flfqlf
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 436-557 4.7e-06 20.9 In-house 14-126 (130) alignment 
Range on Protein: 436-557
Range on HMM: 14-126/130.0
DYINANTINMdipgFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTnVERGrvkcHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAYRDFIICN
.||||. . .     .  ..|. .| || .|  ||| |. |.   ..|.| . ||       .|||| .    .  |. |  |  ||        . | .
tyinasfvGl....lgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdsePlewyeediivtltdrdefknikasnleies

TATKEERIVLQMQYVAWPDHGV
   .  . .  .|   ||  | 
dlneshqaltmfqisnwpsdgt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 445-511 4e-07 23.7 In-house 227-290 (440) alignment 
Range on Protein: 445-511
Range on HMM: 227-290/440.0
MDIPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERgrvKCHKYWPDLDDRLKFGP
 .. |.   | ..|.| ||  || ||| .| . | . |.||    ..    |  |||     . |||
qefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgp
0049260 (Phosphotyrosine protein) phosphatases II 447-639 2.3e-38 126.6 In-house 2-143 (152) alignment 
Range on Protein: 447-639
Range on HMM: 2-143/152.0
IPGFDLVNKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWpdlddrlkfgpdlevrctrcdetpsfayrdfiicntatkeerivlQ
|.|.   ....|.|||.|||..||| |..|.  | |||||. .|.|..||..|.                                             |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................q

MQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMclieanEPVYPLDIVRTERDQRPMLIQTAAQYKFVC
 ... ||||||||.|  .|...| .....   . |..||||||.||||.|. .   .        | ....|.  | .||. ...  |..|. 
ylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 454-638 8.4e-19 62.5 In-house 5-196 (199) alignment 
Range on Protein: 454-638
Range on HMM: 5-196/199.0
NKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAYRDFIICN--TATKEERIVLQMQYVA
 .|.|.| || .|. ||| ||||  |  |||.  .     .    |||  .        | | .      | ..   .|..|  ||    | . . |. .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDdSSDFLDFVLRVRQCR----VGMDVPTIVHCSAGIGRTGVLITMETAMCLIEA-NEPVY-PLDIVRTERDQRPMLIQTAAQYKFV
| ..  |.  . |. ||.  |.         | | ||||| | | |||.....  .   |  .  |   ... .  |. |  .| .  .|.|.
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 454-558 2.7e-07 24.5 In-house 137-237 (244) alignment 
Range on Protein: 454-558
Range on HMM: 137-237/244.0
NKYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTnVERGrvkcHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWP
 .|. .| || .|  ||| |. |.   ..|.| . ||       .|||| .    .  |. |  |  ||       .. |     .  . .  .|   ||
aeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veee....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwp

DHGV-P
  |  |
sdgttp
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 455-638 8.3e-19 62.5 In-house 5-195 (198) alignment 
Range on Protein: 455-638
Range on HMM: 5-195/198.0
KYVAAQGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPDLDDRLKFGPDLEVRCTRCDETPSFAYRDFIICN--TATKEERIVLQMQYVAW
.|.|.| || .|. ||| ||||  |  |||.  .     .    |||  .        | | .      | ..   .|..|  ||    | . . |. .|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPDdSSDFLDFVLRVRQCR----VGMDVPTIVHCSAGIGRTGVLITMETAMCLIEA-NEPVY-PLDIVRTERDQRPMLIQTAAQYKFV
 ..  |.  . |. ||.  |.         | | ||||| | | |||.....  .   |  .  |   ... .  |. |  .| .  .|.|.
kekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 460-648 2.7e-17 57.2 In-house 97-290 (302) alignment 
Range on Protein: 460-648
Range on HMM: 97-290/302.0
QGPLPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWPD-LDDRLKFGP------DLEVRCTRCDETPSFAYRDFIICNTAT--KEERIVLQMQYV
  |  .|.. .| .. . . ...| |.. || .  || .|. | ....||||       ...    .  .  ||      | |. .  | .. |  ... 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPDHGVPDDSSDFLDFVlrvRQCRVgMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYMD
|||||| |...   || .   . |        .||||||.|||| |...   . |   ..    |.||   |. |   .|.. |  ..   . .  |.
awpdhGapkeaytaldil...kfces.ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme
subfamily_hpo-7_pd Subfamily hpo-7 463-647 2.1e-15 51.3 In-house 43-228 (263) alignment 
Range on Protein: 463-647
Range on HMM: 43-228/263.0
LPNTVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP-DLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDS
| .|.. |. ..  .... .|||.   | |..|| .|.| ..|...|.  ...| .|.  . .    ....      |. . | . .|. |...  | ..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla.nvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

SDFLDFVLRVRQCRvgmdvPTIVHCSAGIGRTGVLITMETAMC----LIEANEPV--YPLDIVRTERDQRPMLIQTAAQYKFVCEAIIRVYM
 . |  .  .|. .     . .||||.||||.     .|..       ..  . |    | ...  | .|.  |.|  |  |    .. . .
reilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 466-635 9.8e-18 59.1 In-house 40-210 (255) alignment 
Range on Protein: 466-635
Range on HMM: 40-210/255.0
TVNDFWYMVWEQRSTLIVMLTTNVERGRVKCHKYWP-DLDDRLKFGpDLEVRCTRCDETPSFAYRDFIICNTATKEERIVLQMQYVAWPDHGVPDDSSDF
||. |. ..  .... .|||.   | |..||..|.| ..|..||.  |..| .|.    . .  .. .   .  |. . |   .|  |...  |... . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla.dvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LDFVLRVRQCRvgmdvPTIVHCSAGIGRTGVLITMETAMC----LIEANEPV--YPLDIVRTERDQRPMLIQTAAQY
|  .  ||. .     . .||||.||||.  .. .| .       ..  | |    | ...  | .|.  |.|  | 
lnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql
0048076 (Phosphotyrosine protein) phosphatases II 526-644 2.9e-23 77.6 In-house 36-141 (145) alignment 
Range on Protein: 526-644
Range on HMM: 36-141/145.0
FayrdfiiCNTATKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGmDVPTIVHCSAGIGRTGVLItmetAMCLIEAnEPVYPLDIVRTERDQR
.       ... . .|| ..| .|. ||||||||.....|.|.  .....   . |..||||||.||||.|.    |..|.   . | . ....  | ||
l.......tselellerlgiqylylpwpDhgvpdllellleflefieealke.ggpvlVHCsaGvgRtgtlv....aaylmll.lgvsleealelvrsqr

PMLIQTAAQYKFVCEAIIR
|. ...  |..|..|.. .
pgavpnpgqlrflyefele
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 537-608 8.6e-08 25.9 In-house 213-294 (349) alignment 
Range on Protein: 537-608
Range on HMM: 213-294/349.0
ATKEERIVLQMQYVAWPDHGVPDDSSDFLDFV----------LRVRQCRVGMDVPTIVHCSAGIGRTGVLITMETAMCLIEA
|...  ..||.|.  |.| ..  .   .|  .                      . .|||||| ||||||.|..  . ..| 
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsilep
0048179 (Phosphotyrosine protein) phosphatases II 538-640 6.8e-21 70.0 In-house 43-139 (144) alignment 
Range on Protein: 538-640
Range on HMM: 43-139/144.0
TKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVgMDVPTIVHCSAGIGRTGVLITMEtamcLIEANEpVYPLDIVRTERDQRPMLIQTAAQYKF
. .|| ..| ... ||||||||.....|.|.  .....   . |..||||||.||||.|...     |.  .  . . ....  | .||. ...  |..|
efleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrf

VCE
..|
Lle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 538-645 3e-16 53.8 In-house 85-193 (440) alignment 
Range on Protein: 538-645
Range on HMM: 85-193/440.0
TKEERIVLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRV-GMDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYK
  | | . |..| .|||.|||  ..  | ..  | ...    . | .|||||| |||||.|.... .   . .. .  . .. . |..|| ..||  || 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FVCEAIIRV
|| ||..  
fvheavleg
PTEN_1 540-598 3.9e-07 25.1 In-house 88-149 (196) alignment 
Range on Protein: 540-598
Range on HMM: 88-149/196.0
EERIVLQMQ--YVAWPDHGVPDDSSDFLDFVLRVRQCRVGM-DVPTIVHCSAGIGRTGVLIT
||..  ...   . ..|||.|. |. |   .    ...        .||| ||.||.|... 
eeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
PTPc_DSPc_SM00012 544-643 4.6e-29 96.1 In-house 2-104 (105) alignment 
Range on Protein: 544-643
Range on HMM: 2-104/105.0
VLQMQYVAWPDHGVPDDSSDFLDFVLRVRQCRVGMD--VPTIVHCSAGIGRTGVLITMETAMCLIEAN-EPVYPLDIVRTERDQRPMLIQTAAQYKFVCE
| ...| .|||||||..|...|...  |....   .   |..||||||.||||.......... .|.. . |  ..||.  |.||| ..|| .|| |...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AII
|..
all
0038934 (Phosphotyrosine protein) phosphatases II 545-638 2.8e-07 25.9 In-house 80-169 (194) alignment 
Range on Protein: 545-638
Range on HMM: 80-169/194.0
LQMQYVAWPDHGVPDDSS---DFLDFVLRVRqcRVGMDVPTIVHCSAGIGRTGVLItmetAMCLIEANePVYPLDIVRTERDQRPMLIQTAAQYKFV
..     .||.|.. . .   .|||.| ..   .   .    ||| ||.||||.|.    |  ||. .    . . ... |. ||  |..  ... .
ieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlv....aaYLiyrl.gmsaeeAialfrekRpgaipnqdyleal
subfamily_PTPDC1_pd Subfamily PTPDC1 547-640 5e-09 30.8 In-house 85-170 (182) alignment 
Range on Protein: 547-640
Range on HMM: 85-170/182.0
MQYVAWPDHGVPDdSSDFLDFVlRVRQCRVGMDvPTIVHCSAGIGRTGVLItmetAMCLIEANEpVYPLDIVRTERDQRPMLIQTAAQYKFVCE
.  ..|.|.||.      || | .| .  .  .  . ||| || |||||||    |  |. |.. . . . ... |..||  |||  | ..| |
vynfgwkDygvas.leriLdiv.kvvafalqeg.kvavhChaGlGrtGvli....acylvyakr.ltaekaiklvrskrpksiqtreqvelvke
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 578-643 8.9e-13 42.7 In-house 227-292 (297) alignment 
Range on Protein: 578-643
Range on HMM: 227-292/297.0
MDVPTIVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
 .....||||||.||.||..  .. .  .  .       |..  |.||..|.||  |.... .|..
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_CG42327_pd Subfamily CG42327 581-641 4e-09 30.6 In-house 249-310 (319) alignment 
Range on Protein: 581-641
Range on HMM: 249-310/319.0
PTIVHCSAGIGRTGVLITMETAMCLIEAN-EPVYPLDIVRTERDQRPMLIQTAAQYKFVCEA
| .|||| |.||||..|. . |.  .| . . |   ..|   | .|   ..|  ||.|.   
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 583-643 1.1e-08 29.4 In-house 2-62 (69) alignment 
Range on Protein: 583-643
Range on HMM: 2-62/69.0
IVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
.||||.| |||| .|..   |  | ..  |  .. |.  |  |||..    .| |. .|..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 583-643 1.8e-08 28.6 In-house 1-61 (69) alignment 
Range on Protein: 583-643
Range on HMM: 1-61/69.0
IVHCSAGIGRTGVLITMETAMCLIEANEPVYPLDIVRTERDQRPMLIQTAAQYKFVCEAII
.||||.| |||| .|..   |  | ..  |  .. |.  |  |||..    .| |. .|..
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv