Gene PTPN6-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP063_AA protein Get Run
SpurP063_AA_194-353 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 195-345 4.8e-58 191.5 In-house 52-182 (306) alignment 
Range on Protein: 195-345
Range on HMM: 52-182/306.0
SDWMCKDCIICIFPFiDHSRVII-NDGLPG-DYINGNYIDlpKAWKNSielqqqgenvekidmswehQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMT
 ....|... .|.|| ||.|||. ....|| ||||.|||.  |..|.|                   .|.||||||||..||..|||..|||||||||||
penkeknryknilPf.Dhtrvilkepsvpgsdyinanyik..kevkgs...................dksyiatqgclettvsdFWrmvwqensrvivmt

TKEVERGKNKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKDFN
||||||||.||.|||||...|...|.|.||..||.|.|||.|||.|.|.|...
tkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkk
0049772 (Phosphotyrosine protein) phosphatases II 195-309 7.9e-09 31.1 In-house 44-156 (314) alignment 
Range on Protein: 195-309
Range on HMM: 44-156/314.0
SDWMCKDCIICIFPFIdhSRVIInDGLPG---DYINGNYIDLPkawknsielqqqgenvekidmswehqKRYIATQGCLKDTVPEF----------WRVA
   . |.  . |.|.   .|||. .|||.   |||| .|.| .                          ...||||| |. ||  |          ||. 
flnrdknryldilpad..nrvil.pglpvsgsdyinasyvdgf..........................lkfIatqgpleitvvdfreepvlyyngwrmv

--WQENSRVIVM---------------------TTKEVERGknkccrywpD
  .. |.|.|||                      ..  ..|         .
lrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.........n
0047943 (Phosphotyrosine protein) phosphatases II 198-344 6.4e-34 113.1 In-house 39-162 (273) alignment 
Range on Protein: 198-344
Range on HMM: 39-162/273.0
MCKDCIICIFPFiDHSRVIInDGLPGDYINGNYIDLPkawknsielqqqgenvekidmswEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVE
. |. .  |.|. |||||.. .. . |||| .|.|..                       ......||||| |..|| .|||  |..|.||||| |..||
kdknrykdilpy.dhsrvkl.gdggsdyinAsyvdgy.......................nlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve

RGKNKCCRYWPDANT--KKDTGVITVTHISEQSMADYDLREFSMSHKDF
.|..||..|||. .   ..  | .|||..||.. .|| .|.. ......
lgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 198-314 1.8e-08 28.8 In-house 44-135 (288) alignment 
Range on Protein: 198-314
Range on HMM: 44-135/288.0
MCKDCIICIfPFIDHSRVIINDGlPGDYINGNYIDlpkawknsielqqqgenvekidmSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVE
 ..|    . |  | .|| ..|  |  ||. | .                        | ....| | .|  |. |. |.|..  ... . ||| .. .|
ptrdryenl.prcditrvklsdd.pdfyiaanvvs.......................sakykrrlicaqaPlngtieelWkmllesdveyivmlcelle

RGKNKCCRYWPDANTKK
.||.|   |.|    .|
kGkeksaeyfPsklGek
0039614 (Phosphotyrosine protein) phosphatases II 205-343 3.8e-29 97.5 In-house 63-180 (297) alignment 
Range on Protein: 205-343
Range on HMM: 63-180/297.0
CIFPFIDHSRVIIND--G--LPGDYINGNYIDLPKAwknsielqqqgenvekidmsweHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGK
  ..  |||||....  |  |. |||| .|.| ..                       .....|||||.|..||  |||  |.....|||| ||.||.|.
kdilpydhsrvklkpedgvdldsdYinAsyvdgydl......................ltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr

nKCCRYWPDANTkkDTGVITVTHISEQSMADYDLREFSMSHKD
 ||..|||.  .    | .||| ....  ..| .|........
.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnng
subfamily_PTPN3_pd Subfamily PTPN3 206-342 3.1e-25 83.7 In-house 50-165 (280) alignment 
Range on Protein: 206-342
Range on HMM: 50-165/280.0
IFPFiDHSRVIINDGLPgDYINGNYIDLpkawknsiELQqqgenvekidmSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCR
| |. |. ||.....   |||| ||...        |..           | .  .||||||| |..|. .||.. |...|..||| |  ||||. ||..
ilpy.datrvklkeset.dyinanyvnm........eip...........stglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHK
|||. . . . | ..|.  .|..   | |||. ...|
yWPetedeleygefsvkcekedetksyvlrelvlkdk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 206-329 1.2e-18 61.9 In-house 56-172 (350) alignment 
Range on Protein: 206-329
Range on HMM: 56-172/350.0
IFPFiDHSRVIINDG-----------LPGDYINGNYIDLPKAwKNSIELQQqgenvekidmswehqkRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTK
|.|. .||||... .            . |||| ||. |..    .|. .                 .|||||. |. || .|..|  . . .||.. |.
ilPY.ehsrvkLkkslkssdakkhslstnDYinanYlkltrf.sveinpdf................kYiatqaPlpstvddfykvillnkvkvilslts

EVERGKNKCCRYWPDANTKKDTGVITVTHISEQSM
.|| . .|| |||.. . .. |  .. .. .  ..
dvelnlekcyrYWqegsydditvklaskwenimgi
0036941 (Phosphotyrosine protein) phosphatases II 207-342 3.1e-32 107.5 In-house 48-162 (297) alignment 
Range on Protein: 207-342
Range on HMM: 48-162/297.0
FPFIDHSRVIInDGLPGDYINGNYIDlpkawknsielqqqgenvekidmSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRY
..  ||.||.. |. . ||||..|.|                        .......|||||.|..|| .|||  |..|..|||| |..||.|..||..|
ilpydhtRVkl.ddegsdYinAsyvd.......................gydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WPDA-NTKKDTGVITVTHISEQS--MADYDLREFSMSHK
||.  .  .  | .||| .|...   .|| ||.. ....
wpleegesltygdftvtllsvevvllddytlrtlevtdt
0040438 (Phosphotyrosine protein) phosphatases II 207-342 3.3e-32 107.4 In-house 52-166 (317) alignment 
Range on Protein: 207-342
Range on HMM: 52-166/317.0
FPFIDHSRVIINDGL---PGDYINGNYIDlpkawknsielqqqgenvekidmSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKC
..  |||||....     . |||| .|.|                        .......|||||.|..||  |||  |.....|||| |...|.|..||
ilpydhsRVkLsplggdldsdYInAsyvd.......................gpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekc

CRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHK
..|||. ....  | .|||..||. .|.. ||.. ....
aqYwpl.getltygdftvtllseeelagitlrtlevedl
0045450 (Phosphotyrosine protein) phosphatases II 207-343 1.2e-31 106.0 In-house 64-189 (307) alignment 
Range on Protein: 207-343
Range on HMM: 64-189/307.0
FPFIDHSRVIINDGLP----GDYINGNYIDLPKAWknsielqqqgenvekIDMSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNK
..  ||.||....  .    .||||..|...|  .               .  .. .....|||||.|..|| .|||  |.....|||| |..||.|..|
ilpydhtRVklssldgsledsdYiNAsyvrvplll...............lldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrek

CCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKD
|..|||| ....  | .||| .||. ...| .| . ....|
caqywPdegeeltygnftvtllseehldgytvrtlevtdld
0043336 (Phosphotyrosine protein) phosphatases II 207-342 1.9e-29 98.4 In-house 54-167 (278) alignment 
Range on Protein: 207-342
Range on HMM: 54-167/278.0
FPFIDHSRVIIND---GLPGDYINGNYIDlpkawknsielqqqgenvekidmSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKC
..  |||||....    |. |||| .|.|                        .......|||||.|..||  |||  |......||| |..||.|..||
ilpydhsrvklsllggdldsdYinAsyvd.......................gynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkc

CRYWPdaNTKKDTGVITVTHISEQSMADYDLREFSMSHK
..|||  .. .  | .||| ..|....|| .| . ....
aqYwp..ggsltygdftvtllkeehlddytvrtlevtnl
0040439 (Phosphotyrosine protein) phosphatases II 207-342 3.5e-28 94.3 In-house 20-134 (249) alignment 
Range on Protein: 207-342
Range on HMM: 20-134/249.0
FPFIDHSRVII---NDGLPGDYINGNYIDlpkawknsielqqqgenvekidmSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKC
..  |||||..   ... ..|||| .|||                        . ...|.|||||.|..||. |||  |.....|||| |..||.|..||
ilpydhsrvklsilpglflsdyinAsyid.......................gyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekc

CRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHK
..|||. .. .  | .||| .|.....|| .|.. ....
aqywpl.ggsleygdftvtllsvevkddytvrtleltnl
0050432 (Phosphotyrosine protein) phosphatases II 208-342 1.4e-34 115.2 In-house 78-191 (308) alignment 
Range on Protein: 208-342
Range on HMM: 78-191/308.0
PFIDHSRVIIndGLPGDYINGNYIDLPKawknsielqqqgenvekidmsWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYW
.  |||||..  . . |||| .|.|..                      . .....|||||.|..||  |||  |..|.||||| ||.||.|..||..||
lpydhsRVkl..degsdYInAsyvdgys.....................sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYw

PDA--NTKKDTGVITVTHISEQSMADYDLREFSMSHK
|.   .. .  | .|||..||....|| .|.. ....
plelgggsleygkftvtllseevlddytvrtleltnl
0046845 (Phosphotyrosine protein) phosphatases II 208-343 1.1e-33 112.3 In-house 38-159 (284) alignment 
Range on Protein: 208-343
Range on HMM: 38-159/284.0
PFIDHSRVIINDGLP----GDYINGNYIDLPKAWKNsielqqqgenvekidmswEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKC
.  |||||...   .    .|||| .|.| .                        ..|..||||| |..|| .|||. |..|.||||| |..||.|..||
lpydhsRVklksldgdledsdYinAsyvdgydldlt..................yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekc

CRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKD
..|||. ....  | .||| .||. . || .|........
aqYwplegevltygdftvtllseevkddytvrtleltnlg
0051299 (Phosphotyrosine protein) phosphatases II 208-342 5.1e-33 110.2 In-house 59-172 (288) alignment 
Range on Protein: 208-342
Range on HMM: 59-172/288.0
PFIDHSRVIINDG---LPGDYINGNYIDLPKAWknsielqqqgenvekidmswehqKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCC
.  |||||....     ..|||| .|||...                         ...|||||.|..|| .|||  |..|.||||| ||.||.|..||.
lpydhsRVkLsvldgvegsdYinAsyidgynlk.......................rkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekca

RYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHK
.|||. ....  | |||| .||....|| .|.. ....
qYwpl.ggsltygditvtllseevlddytvrtlevtnl
Y_phosphatase Protein-tyrosine phosphatase 208-345 1.3e-30 102.0 Pfam-A 11-129 (235) alignment 
Range on Protein: 208-345
Range on HMM: 11-129/235.0
PFIDHSRVII-NDGLPGDYINGNYIdlpkawknsielqqqgenvekidMSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRY
. .|..|| . ... | |||| ||.                       ......|..|||||.||.|. .|||. |||...|||| |...|.|..|| .|
lpydktrvklkgsegpsdYInAnyv.......................kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqY

WP-DANTKKDTGVITVTHI-SEQ-SMADYDLREFSMSHKDFN
|| . .... .| |.|.   .|.  ...| ||......|. .
wpeeeeesltygdikvelkekekedekeytlrklelkkkkee
Y_phosphatase Protein-tyrosine phosphatase 208-345 1.3e-30 102.0 In-house 11-129 (235) alignment 
Range on Protein: 208-345
Range on HMM: 11-129/235.0
PFIDHSRVII-NDGLPGDYINGNYIdlpkawknsielqqqgenvekidMSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRY
. .|..|| . ... | |||| ||.                       ......|..|||||.||.|. .|||. |||...|||| |...|.|..|| .|
lpydktrvklkgsegpsdYInAnyv.......................kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqY

WP-DANTKKDTGVITVTHI-SEQ-SMADYDLREFSMSHKDFN
|| . .... .| |.|.   .|.  ...| ||......|. .
wpeeeeesltygdikvelkekekedekeytlrklelkkkkee
0042113 (Phosphotyrosine protein) phosphatases II 208-341 1.4e-26 88.9 In-house 19-131 (245) alignment 
Range on Protein: 208-341
Range on HMM: 19-131/245.0
PFIDHSRVIINDGL---PGDYINGNYIDlpkawknsielqqqgenvekidmSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCC
.  ||.||....       |||| .|.|                         .. ...||||| |..||. |||  |......||| |.|.|.|..||.
lpydhtrvklspdggdldsdyinasyvd.......................gyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkca

RYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSH
.|||. .... .| .||| .||....|| .|......
qywpl.gesltygdftvtllseehlddytvrtlevtn
0037934 (Phosphotyrosine protein) phosphatases II 208-343 1.6e-26 88.7 In-house 20-127 (243) alignment 
Range on Protein: 208-343
Range on HMM: 20-127/243.0
PFIDHSRVIINDglpGDYINGNYIDLPKawknsielqqqgenvekidmswehqkRYIATQGCLKDTVPE----FWRVAWQENSRVIVMTTKEVERGKNKC
.  |||||....   .||||.|.|. ..                          |.||||| |..|| .    |||  |.....|||| |..||.|..||
lpydhsrvkleg...sdyinanliyvtp..........................rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekc

CRYWPdaNTKkDTGVITVTHISEQSMADYDLREFSMSHKD
..|||  ...   | .||| .||....|| .|.......|
aqywp..gev.tygdftvtllseehlddytvrtlllenld
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 208-341 7.9e-06 20.2 In-house 28-152 (290) alignment 
Range on Protein: 208-341
Range on HMM: 28-152/290.0
PFIDHSRVIIND---GLPGDYINGNYIDLPKAWKNSIELQQQGENvekidmswehqkryiatQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKN---
|.. ..||....    .  |||  |..  |.  .  .    | ..                     . |. .|| .| ||... .||. .  |. .|   
pLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqeki.................tekrnStiekfwwmakqEkvkqvVmlcefeeksantsl

-KCCRYWPDANT-KKDTGVITVTHISEQSMADYDLREFSMSH
  | .| |..   .   . .||   |     | . ||  . .
faCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkf
DSPc_SM00195 209-343 5.7e-33 109.7 In-house 37-153 (263) alignment 
Range on Protein: 209-343
Range on HMM: 37-153/263.0
FIDHSRVIINDGL---PGDYINGNYIDLPkawknsielqqqgenvekidmswEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCR
 .||.||....     . |||| |||...                       ...|.||||||.|..|| .|||. |.|....|||.|.|.|.||.|| |
pydhtrVklkkeekkegsdYINAnyikga.......................nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YWPDA-NTKKDTGVITVTHISEQSMA-DYDLREFSMSHKD
|||.  ..|.. | |.|. ......  .. ||........
ywpeesggketfgkisvklvevekkkdeiilrtleltkeg
PTPc_SM00194 209-343 5.7e-33 109.7 In-house 37-153 (263) alignment 
Range on Protein: 209-343
Range on HMM: 37-153/263.0
FIDHSRVIINDGL---PGDYINGNYIDLPkawknsielqqqgenvekidmswEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCR
 .||.||....     . |||| |||...                       ...|.||||||.|..|| .|||. |.|....|||.|.|.|.||.|| |
pydhtrVklkkeekkegsdYINAnyikga.......................nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YWPDA-NTKKDTGVITVTHISEQSMA-DYDLREFSMSHKD
|||.  ..|.. | |.|. ......  .. ||........
ywpeesggketfgkisvklvevekkkdeiilrtleltkeg
0045098 (Phosphotyrosine protein) phosphatases II 209-342 1.3e-29 98.9 In-house 44-144 (278) alignment 
Range on Protein: 209-342
Range on HMM: 44-144/278.0
FIDHSRVIindglpgDYINGNYIDLPkawKNsielqqqgenvekidmswehqkRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWP
 .|||||.       |||| .||| .   ..                      ..|||||.|..||  |||  |.....|||| |..||.|..||..|||
pydhsrVk.......dYINAsyidgy...pk......................kfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

DaNTKKDTGVITVTHISEQSMADYDLREFSMSHK
. .  .  | .||| .||. . || || . . . 
e.ggsltygdftvtllseevlddytlrtllvtnl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 210-343 9.8e-23 75.8 In-house 68-180 (298) alignment 
Range on Protein: 210-343
Range on HMM: 68-180/298.0
IDHSRVIIND---GLPGDYINGNYIDlpkawknsielqqqgenvekidmSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRY
.|.|||....      .||||  ...                       ...... .||||. |. || .|||. ..|.. .||| |. .| .| |. .|
ldssRvvLekedadeesdYiNAsflh.......................aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhky

WPDANTKkDTGVITVTHISEQSMADYDLREFSMSHKD
||| ...   | |||.  |....||.  |.. .|.|.
wPdegke.tygeitvsllskeefadlivrklkvskkk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 210-313 1.3e-12 41.7 In-house 77-159 (349) alignment 
Range on Protein: 210-313
Range on HMM: 77-159/349.0
IDHSRVIINDGLPGDYINGNYIDLPKAWKNSielqqqgenvekidmswehqkRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPD
|..|.   . | . |||| ||. |..   .                      .|||||  |  || .|..|   .. ....  ... | . .|| .|| .
ikastsesdsgklddyinanylkltrisvek.....................kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe

ANTK
 . .
lsys
subfamily_PTPRK_pd Subfamily PTPRK 211-341 3.1e-22 73.8 In-house 56-164 (314) alignment 
Range on Protein: 211-341
Range on HMM: 56-164/314.0
DHSRVIIN---DGLPGDYINGNYIdlpkawknsielqqqgenvekidMSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYW
|.|||..    .    ||||...|                        |... . .|.||| |..|| .|||. ..||.  ||| |. || |. ||..||
drsrvflitidgdpssdyinaali.......................dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW

PDANTKkdTGVITVTHISEQSMADYDLREFSMSH
|.  ..   | | |. .. .  |..  | |....
Pedtev..ygdikvelvetellaelvvrifrvek
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 211-339 1.5e-19 65.0 In-house 46-152 (283) alignment 
Range on Protein: 211-339
Range on HMM: 46-152/283.0
DHSRVIINdGLPGDYINGNYIDLpkawknsielqqqgenvekiDMSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDA
|  || ..  .. ||||  .| .                    . | ...|.||..|. |..|| .||.. ..|.   ||| ||  |  . ||..|||  
dqwrvelk.sesrdyinavfipv....................sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

NTkKDTGVITVTHISEQSMADYDLREFSM
 . .| |  |||   | .   .  .|. .
Gs.edyGeftvtlrkettsnsfiikelll
0041856 (Phosphotyrosine protein) phosphatases II 214-318 4.8e-12 41.3 In-house 17-76 (182) alignment 
Range on Protein: 214-318
Range on HMM: 17-76/182.0
RviindglPGDYINGNYIDlpkawknsielqqqgenvekidMSWEHQKrYIATQGCLKDTVPEFWRVAWQENSRVIVMTTkevergknkCCRYWPDANtk
|       . |||| |...                      .|. ... .||||| |..||..|.|  .... ..||. |         ...|||.    
r.......dldyInanlyl......................gslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell..

kdtgV
     
....e
0046846 (Phosphotyrosine protein) phosphatases II 218-312 1.6e-12 43.0 In-house 7-74 (176) alignment 
Range on Protein: 218-312
Range on HMM: 7-74/176.0
NDGLPGDYINGNYIDLPKawknsielqqqgenvekidmswehqkrYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANT
 ..|. ||||.|.|. ..                           .||||| | .|...|..  .... ...|. |.||| |. ||..|||.  .
gldldldyinanlilgsr...........................piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpelek
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 223-338 6.3e-21 69.6 In-house 48-144 (270) alignment 
Range on Protein: 223-338
Range on HMM: 48-144/270.0
GDYINGNYIDlpkawknsielqqqgenvekiDMSWEhQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTK---KDTGVI
  ||| ||.                       .. | .|.|||..| |. |. .|||. |.|... |||||. .|.|..|| ||||  . .     .| |
taYinAnyvr.....................Gfdge.kkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgki

TVTHISEQSMADYDLREFS
.|. .||. .  | |..  
kvlalseekeegyiltrlr
0051429 (Phosphotyrosine protein) phosphatases II 224-342 2.3e-15 52.5 In-house 5-113 (272) alignment 
Range on Protein: 224-342
Range on HMM: 5-113/272.0
DYINGNYIDLPkawknsielqqqgenvekidMSWEHQKRYIATQGCLKDTVPEFWRVaWQENSRVIVMTTKEVERGKNKCCRYWP-----------DANT
.||| .... .                     ..   .|.....|.|. |. .|||  .... ..||. ..|.|||..|| ||||           |. .
gyiNardvggy....................grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsap

KKDTGVITVTHISEQSMADYDLREFSMSHK
    | ..||..||. . || |||. ....
tilygalrvtllseellldyilrellltll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 246-341 4.3e-19 63.3 In-house 71-166 (301) alignment 
Range on Protein: 246-341
Range on HMM: 71-166/301.0
QGENVEKIDMsWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSH
.  | . ||    ..|..||.|| .| |. .|||. |||    ||| |.. |. |.|| .|||..... .. | .||| ..|| . |. .|....  
eyinasyidg.ysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvki
0043147 (Phosphotyrosine protein) phosphatases II 248-311 7.1e-09 31.1 In-house 8-77 (172) alignment 
Range on Protein: 248-311
Range on HMM: 8-77/172.0
ENVEKIDMSWeHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKE-------VERGKNKCCRYWPDAN
.|.. .|... . .|.|||||.|  |...|||  .... ..||. |..       .. |   .. .||| .
inasyldlyy.ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhg
subfamily_ptpA1_pd Subfamily ptpA1 252-310 5.9e-14 46.6 In-house 82-138 (418) alignment 
Range on Protein: 252-310
Range on HMM: 82-138/418.0
KIDMSweHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDA
 || .  . |..|.||| | .|. .|||. |..  |.||| ..| |  . || ||||. 
yidga..ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq
0036282 (Phosphotyrosine protein) phosphatases II 252-353 4.1e-12 41.6 In-house 9-79 (174) alignment 
Range on Protein: 252-353
Range on HMM: 9-79/174.0
KIDMSWEHQkRYIATQGCLKdtvpeFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDantkkdtgvitvthiseqsmadydlREFSMSHKDFNKCCRYW
 .|.|.    |.||.||.|.     ||.  ........|| ..|.|.|. ||..|||.                         .  .... ... ..  |
pldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.........................lredlerlgiqylylpw

PD
||
pD
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 253-342 3.2e-22 73.9 In-house 72-165 (281) alignment 
Range on Protein: 253-342
Range on HMM: 72-165/281.0
IDMSW----EHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHK
|. ..    . .|.|||||| . ... .||.. |... ..||| |.|.| || || ||||| |..   | .||....|.. | |  |.|.....
inanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfklere
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 253-330 1.7e-09 32.1 In-house 67-147 (285) alignment 
Range on Protein: 253-330
Range on HMM: 67-147/285.0
IDMSWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANT---KKDTGVITVTHISEQSMA
. |  . |  ||.||| | .|. .||.. .||.   ..|    .| | .||. |.|.      |     ||.|   |...|
mrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaia
subfamily_PTPRG_pd Subfamily PTPRG 256-343 3.9e-24 79.8 In-house 86-172 (563) alignment 
Range on Protein: 256-343
Range on HMM: 86-172/563.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHKD
 ....| .||||| ||||.  |||. |..|. .||| |. ||||..|| .|||  .. .. |...|| |.|. .| |  |.... .  
GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 256-343 8.6e-23 75.9 In-house 84-172 (305) alignment 
Range on Protein: 256-343
Range on HMM: 84-172/305.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSHKD
.....|.||..|| ||.|| .|||. ..|  ..||| || || ||.|| .|||.. |. |. | ..|.  ||....||  |....| .|
gykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisied
subfamily_Ptp69D_pd Subfamily Ptp69D 256-343 4.8e-21 70.2 In-house 86-172 (307) alignment 
Range on Protein: 256-343
Range on HMM: 86-172/307.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDAnTKKDTGVITVTHISEQSMADYDLREFSMSHKD
.....|..|| |. .  |. .|||. .. .. .||| ... |  ..|| .|||.  ...  | | |. .||... ||  ||...|.|.
gykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 256-342 5e-21 70.1 In-house 86-171 (319) alignment 
Range on Protein: 256-342
Range on HMM: 86-171/319.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKkDTGVITVTHISEQSMADYDLREFSMSHK
........||||. |..|. .|||. |.|.| ..|| || ||..| |. .|||..| . . | ..||  .|. ..||  |.... .|
gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfe.eyGrlivtleeeeeledyiirklklnkk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 256-342 5.5e-21 69.9 In-house 68-157 (274) alignment 
Range on Protein: 256-342
Range on HMM: 68-157/274.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTK---KDTGVITVTHISEQSMADYDLREFSMSHK
  |..| |.|||| |  || .|||. .||...||||.||  |. ..|| .|.|||.     .  | . ..  .  .  || .|...... 
ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 256-345 6.6e-19 62.8 In-house 75-165 (287) alignment 
Range on Protein: 256-345
Range on HMM: 75-165/287.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDTGVITVTHISEQSM-ADYDLREFSMSHKDFN
|.......||.|| .  || .|||. ....| .... |.||| ...|| .|||. .     |  .|. .. . .  .|  | . . . . .
sytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 256-342 4.8e-18 60.1 In-house 81-166 (287) alignment 
Range on Protein: 256-342
Range on HMM: 81-166/287.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMSHK
.....|..|.... . .|. .||.. ...|  .||| ..| |  ...| .|||. ..    |  ... ..|. .|.|  |.. . .|
gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 256-342 1.3e-17 58.1 In-house 81-168 (515) alignment 
Range on Protein: 256-342
Range on HMM: 81-168/515.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPD--ANTkKDTGVITVTHISEQSMADYDLREFSMSHK
| . .| |||.|| .| .| .|||. .|||   |.| ||  |  | || .||||  ...    | | |  .| .. ..   |.. . . 
sfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds.vkfGsikvelvsleactggikrkltvlkg
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 256-340 1.4e-16 55.2 In-house 82-167 (315) alignment 
Range on Protein: 256-340
Range on HMM: 82-167/315.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPD-ANTKKDTGVITVTHISEQSMADYDLREFSMS
| ...| |||.|| || .| .|||. .||.   ||| ||  |  | || .||||      . | | |. .| .. .|   |.. . 
svdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtr
subfamily_CG7180_pd Subfamily CG7180 256-341 4.6e-15 50.0 In-house 80-163 (296) alignment 
Range on Protein: 256-341
Range on HMM: 80-163/296.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKnKCCRYWPDANtKKDTGVITVTHISEQSMADYDLREFSMSH
|. ..| || |..  |.|| ||||. ..|..  .|. ||. .  | ..  |||    |.. | | |  ..|...|.   |.| . .
sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 256-319 1.3e-10 35.3 In-house 83-154 (392) alignment 
Range on Protein: 256-319
Range on HMM: 83-154/392.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTK--EVERGKN--KCCRY----WPDANTKKDTGVI
| . .| |||.||    .. .|||. .|||   |.| ||  | ..|..   ....    |||..  | |  .
sfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewPdkdvpkhtssl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 256-342 1.8e-08 28.7 In-house 67-151 (267) alignment 
Range on Protein: 256-342
Range on HMM: 67-151/267.0
SWEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEverGKNKCCRYWPDA-NTKKDTGVITVTHISEQSMADYDLREFSMSHK
... .. .|.||. || |. .|. |  ...  |||. ||    ....  ..||      |    .|| |  |.   ||..  . .  |
gyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfk
subfamily_PTPRD_pd Subfamily PTPRD 257-342 3.1e-29 97.1 In-house 87-171 (564) alignment 
Range on Protein: 257-342
Range on HMM: 87-171/564.0
WEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANtKKDTGVITVTHISEQSMADYDLREFSMSHK
....| |||||| |..|. .|||  |..||..||| || .|.||.|| .|||. . ..  | .|||  .|. .||| .|.|....|
yrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkk
subfamily_PTPRB_pd Subfamily PTPRB 257-342 1.8e-26 87.9 In-house 90-175 (293) alignment 
Range on Protein: 257-342
Range on HMM: 90-175/293.0
WEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHK
 . .. .||||| | .|| .|||. |...|..||| |. ||.|| || .|||. ..    | |.|| ..|... |. .||......
ynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkieke
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 257-343 3.2e-26 87.1 In-house 85-170 (318) alignment 
Range on Protein: 257-343
Range on HMM: 85-170/318.0
WEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKkDTGVITVTHISEQSMADYDLREFSMSHKD
....| |||.|. | .|...|||. |. ||.|||| |.|.||||.|. ||||. ...   | ..|.  .| ...|| ||||......
yrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrte
subfamily_PTPN9_pd Subfamily PTPN9 257-341 1.3e-24 81.8 In-house 81-166 (297) alignment 
Range on Protein: 257-341
Range on HMM: 81-166/297.0
WEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWP-DANTKKDTGVITVTHISEQSMADYDLREFSMSH
....| .||||| || || .|||. |... .||||||. ||||. || .||| . .. .. | ..|.... ... ||  | . ...
ykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleikn
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 257-342 2.2e-22 74.3 In-house 87-171 (290) alignment 
Range on Protein: 257-342
Range on HMM: 87-171/290.0
WEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKdTGVITVTHISEQSMADYDLREFSMSHK
....|.|||||| ...|. .||.. |||.. .||| |...| ||.||  ||||..||.  | .... ..|... .|  |.... .|
ykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 257-343 5.2e-20 66.6 In-house 88-172 (315) alignment 
Range on Protein: 257-343
Range on HMM: 88-172/315.0
WEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDAntKKDTGVITVTHISEQSMADYDLREFSMSHKD
.....||||.|| .  .| .|||. ..|.   ||| |. ||. |.|. .||||   |   | ||||..||.   .|  | .|.  .|
ynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 257-342 5.7e-20 66.6 In-house 48-131 (250) alignment 
Range on Protein: 257-342
Range on HMM: 48-131/250.0
WEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNkCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMSHK
.. .| .||||| |..|. .|||. ..|.| .||| |. .| .|. . .|||  .. .  | .||.  |.. .|||  |.. .|..
yderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka.ekyGdvtvsllskeefadytkrklklska
0044763 (Phosphotyrosine protein) phosphatases II 257-333 9.7e-08 27.4 In-house 25-90 (178) alignment 
Range on Protein: 257-333
Range on HMM: 25-90/178.0
WEHQKRYIATQGClkdtvPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTkkdtgvITVTHISEQSMADYD
.     |......     .....  .... ..||. |.|.|.|..||..|||. .       |.. ||    . . |
eilpglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag......iqylhipipDhgvpd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 257-342 3.2e-07 24.0 In-house 232-314 (440) alignment 
Range on Protein: 257-342
Range on HMM: 232-314/440.0
WEHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVErgkNKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHK
. ... .||||  |  || .|||.  . .   |.|  .  .   . |  |||        | .|| |   . |    .| . . .|
yskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 258-342 1.8e-22 74.7 In-house 87-171 (288) alignment 
Range on Protein: 258-342
Range on HMM: 87-171/288.0
EHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHK
...|.|||||| | ||| .||.. .....  ||| |. ||.||.|| .|||||...|  | .||| .... . |. ||.. . .|
kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk
subfamily_PTPN12_pd Subfamily PTPN12 258-342 8.1e-22 72.4 In-house 80-166 (290) alignment 
Range on Protein: 258-342
Range on HMM: 80-166/290.0
EHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKD-TGVITVTHISEQSMA-DYDLREFSMSHK
| ...|||.|| | .|. .|||. |. | ...||  .||| ||.|| ||||. . ..  .| ..|| ..|. .  |. .| . . ..
egkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq
subfamily_PTPN13_pd Subfamily PTPN13 258-342 2.5e-19 64.6 In-house 74-160 (273) alignment 
Range on Protein: 258-342
Range on HMM: 74-160/273.0
EHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDT--GVITVTHISEQSMADYDLREFSMSHK
... .|||.|| | .|| .||.. |. ...||.| |.|.|.|| || ||||. . || .  . ..|. .  | . .. .|.. ....
kdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds
subfamily_PTPN1_pd Subfamily PTPN1 258-340 2.8e-19 63.9 In-house 68-154 (290) alignment 
Range on Protein: 258-340
Range on HMM: 68-154/290.0
EHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANT----KKDTGVITVTHISEQSMADYDLREFSMS
| ...|| ||| | .||  ||.. |...|. .||  | ||....|| .|||  .     . .   ..|. |||..   | .| . . 
eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllele
subfamily_PTPRA_pd Subfamily PTPRA 258-340 3.1e-19 64.0 In-house 98-179 (330) alignment 
Range on Protein: 258-340
Range on HMM: 98-179/330.0
EHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTkKDTGVITVTHISEQSMADYDLREFSMS
......||.|| ...|| .|||. |. .|  ||| |.  || ..|| .||||  .    | |.|.   |. . || .|.| . 
kekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 258-333 4.7e-17 56.8 In-house 73-148 (297) alignment 
Range on Protein: 258-333
Range on HMM: 73-148/297.0
EHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANT-KKDTGVITVTHISEQSMAdYD
|.. .|| .|| |..|| .||.. .... ||||| .|  | |..||  |||...  .. .| . | ..|. |   .|
eadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fd
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 258-342 2.1e-16 55.1 In-house 101-178 (319) alignment 
Range on Protein: 258-342
Range on HMM: 101-178/319.0
EHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTkevergKNKCCRYWPDA-NTKKDTGVITVTHISEQsmADYDLREFSMSHK
 ....|||.|| |..|. .|||. |. |.  ||. |      |.||..|||   . |.. . . |. . |   |.| .|.. .|..
qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveet..aeyvvrdielsed
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 258-342 2.2e-16 55.2 In-house 65-142 (284) alignment 
Range on Protein: 258-342
Range on HMM: 65-142/284.0
EHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTkevergKNKCCRYWPDA-NTKKDTGVITVTHISEQsmADYDLREFSMSHK
 ....|||||| |..|. .|||. |. |.  ||. |      |.||..|||   . |.. . . |. ..|   ..| .|.. .|..
qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsvees..eeyvvrdielsed
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 258-322 1.9e-10 35.0 In-house 87-152 (301) alignment 
Range on Protein: 258-322
Range on HMM: 87-152/301.0
EHQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTK-KDTGVITVT
 | .|.||||| ||.|  .|| .  | .   ||| ...||. ..||  | |   ..  | |  ...
GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkik
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 259-342 3e-21 70.7 In-house 43-126 (237) alignment 
Range on Protein: 259-342
Range on HMM: 43-126/237.0
HQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHK
  |.|||.|| |. .  .||.. |||.  |||| |  .|. . || .|||...  .  ||.||.   .. ..|| .| . .|..
tpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskr
subfamily_PTPN14_pd Subfamily PTPN14 259-316 1.5e-16 55.3 In-house 91-148 (300) alignment 
Range on Protein: 259-316
Range on HMM: 91-148/300.0
HQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDT
... ||..|| |. || .||.. |... ..||| |.| | ||.|. .|.|. . ||.|
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkkt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 259-343 7.5e-16 53.1 In-house 90-172 (297) alignment 
Range on Protein: 259-343
Range on HMM: 90-172/297.0
HQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKnKCCRYWPDANTKKdTGVITVTHISEQSMADYDLREFSMSHKD
 ..|.|.||   |.|| .||.. ..|.  .||| ... || | || |||.|  ...  | ..|.  | ..   .  ||..... .
nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgk
subfamily_PTPRN_pd Subfamily PTPRN 259-337 1.2e-14 48.8 In-house 98-176 (297) alignment 
Range on Protein: 259-337
Range on HMM: 98-176/297.0
HQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTkKDTGVITVTHISEQSMA-DYDLREF
 .  |||||| | .|| .||.. |.. . |||. |.  | | ..| |||||  . .  ..  |  .||   . || .| |
rapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGs.evyhiyevhlvsehiwcddylvrsf
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 259-339 6.4e-14 46.8 In-house 89-169 (325) alignment 
Range on Protein: 259-339
Range on HMM: 89-169/325.0
HQKRYIATQGCLKDTVPEFWRVA--WQenSRVIVMTtKEVERGKNKCCRYWPDA-NTKKDTGVITVTHISEQSMADYDLREFSM
 .. ..|.|  | .|. ..||..  |.  . |.|..  |.. ||..|. |||.     |  | . |  .. . ..||  | . .
kkdvflaaqaPltatindlWrlvldWr..csvvvvl.neldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 259-334 6.1e-09 30.3 In-house 3-79 (199) alignment 
Range on Protein: 259-334
Range on HMM: 3-79/199.0
HQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTK-KDTGVITVTHISEQSMADYDL
 |.||||||  |..|. .||.. |.  |  |||   .    .     ||| ...     | ..||  .  . .|| .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdyti
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 259-340 6.1e-09 29.8 In-house 89-164 (439) alignment 
Range on Protein: 259-340
Range on HMM: 89-164/439.0
HQKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKnkccrYWPDANtKKDTGVITVTHISEQSMADYDLREFSMS
 .| ||||||  |.|. .|||. .....  ||| |. ||  |     |||  . .   | |.|    .  . .| .| | . 
ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda.evcygdiavrvdrnielpnyvirgfkvf
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 260-341 1.1e-18 62.3 In-house 51-130 (239) alignment 
Range on Protein: 260-341
Range on HMM: 51-130/239.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDTgvITVTHISEQSMADYDLREFSMSH
 | |||||||.. .  .|||. |||   |||| |  .|  |.|| .||||. .|     . ||    . .||| .| | ||.
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn..lrvtlrktevfadyiirtfvmsq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 260-341 1.1e-18 62.3 In-house 50-129 (239) alignment 
Range on Protein: 260-341
Range on HMM: 50-129/239.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDTgvITVTHISEQSMADYDLREFSMSH
 | |||||||.. .  .|||. |||   |||| |  .|  |.|| .||||. .|     . ||    . .||| .| | ||.
pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn..lrvtlrktevfadyiirtfvmsq
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 260-322 3e-14 47.4 In-house 95-159 (305) alignment 
Range on Protein: 260-322
Range on HMM: 95-159/305.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDT--GVITVT
.||.|..|| | .|. ||| .  |..   |||  | || || ||..||| |. .| .  . | | 
ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivve
subfamily_CG42327_pd Subfamily CG42327 260-317 1.3e-13 45.3 In-house 71-128 (319) alignment 
Range on Protein: 260-317
Range on HMM: 71-128/319.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDTG
.  |||.|  |.|.  .|||. |. .|||||  |.  | | ..| .|.|  .| ..| 
pnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 260-309 2.7e-11 37.7 In-house 80-129 (281) alignment 
Range on Protein: 260-309
Range on HMM: 80-129/281.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPD
.. || |||  |.|  .|||. ||||.  |||  . .|  ..||. |.| 
krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 260-321 3.1e-11 37.9 In-house 81-142 (307) alignment 
Range on Protein: 260-321
Range on HMM: 81-142/307.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDTGVITV
 |..|..|| |..|. .|| .| ||.   ..|  | .| .| || .|||  . .| . . . 
pkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeap
0049260 (Phosphotyrosine protein) phosphatases II 260-353 9.9e-11 37.0 In-house 8-64 (152) alignment 
Range on Protein: 260-353
Range on HMM: 8-64/152.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWpdantkkdtgvitvthiseqsmadydlrefsmshkdfNKCCRYWPD
....|||||..  |...|||  .. . ..||| |...|.|| || .|.                                     . .. .|||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.....................................qylhlpwpD
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 260-335 6.8e-09 30.2 In-house 3-79 (198) alignment 
Range on Protein: 260-335
Range on HMM: 3-79/198.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTK-KDTGVITVTHISEQSMADYDLR
|.||||||  |..|. .||.. |.  |  |||   .    .     ||| ...     | ..||  .  . .|| . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytit
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 260-311 7.5e-09 29.7 In-house 87-138 (305) alignment 
Range on Protein: 260-311
Range on HMM: 87-138/305.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDAN
 ||.| ||  |..|  .|| . .|..   | |  . .|.| .||. |..  .
pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskd
subfamily_eak_pd Subfamily eak 260-339 4e-07 23.7 In-house 92-172 (332) alignment 
Range on Protein: 260-339
Range on HMM: 92-172/332.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDAN-TKKDTGVITVTHISEQSMADYDLREFSM
 ..|| |    .| |. ||..  ...|  ||.  ..|| . .|  .|.||    . . |.. |.  .    . .. | . .
GrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllel
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 260-309 3.8e-06 20.8 In-house 81-130 (312) alignment 
Range on Protein: 260-309
Range on HMM: 81-130/312.0
QKRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPD
 .|...||| |..|.  ||..|    |  |.. .  || | .||..|  |
perfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 261-328 4.1e-14 46.8 In-house 94-161 (310) alignment 
Range on Protein: 261-328
Range on HMM: 94-161/310.0
KRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDTGVITVTHISEQS
. .| .|| |. |. .|||. .|| .  |..  | .| |. ||  |||     .  |.| || .|| |
stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsess
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 261-342 6.5e-13 43.0 In-house 94-177 (290) alignment 
Range on Protein: 261-342
Range on HMM: 94-177/290.0
KRYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTKKDT-GVITVTHISEQ-SMADYDLREFSMSHK
  .| ||| ||||| ..||.  ||.  .|||  . .| || || .|.|. . .  | | |||.   |.   |.  .. .|. .|
amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdk
0051082 (Phosphotyrosine protein) phosphatases II 261-346 2.2e-08 29.3 In-house 14-85 (151) alignment 
Range on Protein: 261-346
Range on HMM: 14-85/151.0
KrYIATQGClkdtVPEFWRVAWQENSRVIVMTTKEVERGknKCCRYWPDANtkkdtgvITVTHISEQSMADYDLREFSMSHKDFNK
  .....|      ..|..  .... ..||. ..|.|||  .| .|.|...       |.|.||   .. |..| ..  . ..| .
g.lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.......ievlhipildwpdpglplsfdavlefle
subfamily_egg_pd Subfamily egg 262-323 1.5e-12 41.8 In-house 84-143 (307) alignment 
Range on Protein: 262-323
Range on HMM: 84-143/307.0
RYIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERgkNKCCRYWPDANTKKDTGVITVTH
 .| .|  ||.|| .|||. .||. . ||| |  .|   ..|  ||| |...    |    .
efilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslr
subfamily_PTPN23_pd Subfamily PTPN23 263-344 3.1e-16 54.0 In-house 85-167 (288) alignment 
Range on Protein: 263-344
Range on HMM: 85-167/288.0
YIATQGCLKDTVPEFWRVAWQENSRVIVMTTKEVERGKNKCCRYWPDANTK-KDTGVITVTHISEQSMADYDLREFSMSHKDF
.||||. |. |. .||.. ... |.|||| ... |.||.|. |||| .. . .  | ..||  |....  .  |.......| 
fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 341-384 1.5e-06 22.5 In-house 126-169 (288) alignment 
Range on Protein: 341-384
Range on HMM: 126-169/288.0
HKDFNKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMS
 .. .|| .|||||...|  | .||| .... . |. ||.. . 
eggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 341-387 6.3e-06 20.3 In-house 128-172 (315) alignment 
Range on Protein: 341-387
Range on HMM: 128-172/315.0
HKDFNKCCRYWPDAntKKDTGVITVTHISEQSMADYDLREFSMSHKD
... .|. .||||   |   | ||||..||.   .|  | .|.  .|
egekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgd
0050432 (Phosphotyrosine protein) phosphatases II 342-385 4.3e-07 25.0 In-house 145-190 (308) alignment 
Range on Protein: 342-385
Range on HMM: 145-190/308.0
KDFNKCCRYWPDA--NTKKDTGVITVTHISEQSMADYDLREFSMSH
.. .||..|||.   .. .  | .|||..||....|| .|.. ...
ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltn
0046845 (Phosphotyrosine protein) phosphatases II 342-387 5.8e-07 24.6 In-house 114-159 (284) alignment 
Range on Protein: 342-387
Range on HMM: 114-159/284.0
KDFNKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKD
.. .||..|||. ....  | .||| .||. . || .|........
ngrekcaqYwplegevltygdftvtllseevkddytvrtleltnlg
0042113 (Phosphotyrosine protein) phosphatases II 342-385 3.5e-06 22.1 In-house 89-131 (245) alignment 
Range on Protein: 342-385
Range on HMM: 89-131/245.0
KDFNKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSH
....||..|||. .... .| .||| .||....|| .|......
lgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtn
0040439 (Phosphotyrosine protein) phosphatases II 342-386 5.3e-06 21.7 In-house 91-134 (249) alignment 
Range on Protein: 342-386
Range on HMM: 91-134/249.0
KDFNKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHK
....||..|||. .. .  | .||| .|.....|| .|.. ....
lgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnl
0045098 (Phosphotyrosine protein) phosphatases II 342-386 7.2e-06 21.1 In-house 101-144 (278) alignment 
Range on Protein: 342-386
Range on HMM: 101-144/278.0
KDFNKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHK
.. .||..|||. .  .  | .||| .||. . || || . . . 
lgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 342-386 9.5e-06 19.7 In-house 128-171 (290) alignment 
Range on Protein: 342-386
Range on HMM: 128-171/290.0
KDFNKCCRYWPDANTKKdTGVITVTHISEQSMADYDLREFSMSHK
.. .||  ||||..||.  | .... ..|... .|  |.... .|
egkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknk
0051299 (Phosphotyrosine protein) phosphatases II 343-386 3.2e-07 25.6 In-house 130-172 (288) alignment 
Range on Protein: 343-386
Range on HMM: 130-172/288.0
DFNKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHK
. .||..|||. ....  | |||| .||....|| .|.. ....
grekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnl
0047943 (Phosphotyrosine protein) phosphatases II 343-385 6.4e-06 21.3 In-house 115-159 (273) alignment 
Range on Protein: 343-385
Range on HMM: 115-159/273.0
DFNKCCRYWPDANT--KKDTGVITVTHISEQSMADYDLREFSMSH
. .||..|||. .   ..  | .|||..||.. .|| .|.. ...
grekcaqYwpleggelsltygkftvtllseetkddytvrtleltn
0045450 (Phosphotyrosine protein) phosphatases II 343-386 8.6e-06 21.2 In-house 145-188 (307) alignment 
Range on Protein: 343-386
Range on HMM: 145-188/307.0
DFNKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHK
...||..|||| ....  | .||| .||. ...| .| . ....
grekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl
subfamily_PTPRD_pd Subfamily PTPRD 344-386 3.7e-07 24.2 In-house 130-171 (564) alignment 
Range on Protein: 344-386
Range on HMM: 130-171/564.0
FNKCCRYWPDANtKKDTGVITVTHISEQSMADYDLREFSMSHK
 .|| .|||. . ..  | .|||  .|. .||| .|.|....|
kvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkk
0040438 (Phosphotyrosine protein) phosphatases II 344-386 1.1e-06 23.6 In-house 125-166 (317) alignment 
Range on Protein: 344-386
Range on HMM: 125-166/317.0
FNKCCRYWPDaNTKKDTGVITVTHISEQSMADYDLREFSMSHK
 .||..|||. ....  | .|||..||. .|.. ||.. ....
rekcaqYwpl.getltygdftvtllseeelagitlrtlevedl
subfamily_PTPN6_pd Subfamily PTPN6 345-387 2.7e-16 54.4 In-house 138-180 (306) alignment 
Range on Protein: 345-387
Range on HMM: 138-180/306.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHKD
.||.|||||...|...|.|.||..||.|.|||.|||.|.|.|.
ekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkk
subfamily_PTPRB_pd Subfamily PTPRB 345-386 1.4e-06 22.5 In-house 134-175 (293) alignment 
Range on Protein: 345-386
Range on HMM: 134-175/293.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSHK
 || .|||. ..    | |.|| ..|... |. .||......
vkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkieke
subfamily_Ptp69D_pd Subfamily Ptp69D 345-387 1.5e-06 22.5 In-house 131-172 (307) alignment 
Range on Protein: 345-387
Range on HMM: 131-172/307.0
NKCCRYWPDAnTKKDTGVITVTHISEQSMADYDLREFSMSHKD
.|| .|||.  ...  | | |. .||... ||  ||...|.|.
kkcakYWpie.devqygdilvklvseekhsdyiiReldvskkk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 345-385 2.9e-06 21.7 In-house 85-125 (237) alignment 
Range on Protein: 345-385
Range on HMM: 85-125/237.0
NKCCRYWPDANTKKDTGVITVTHISEQSMADYDLREFSMSH
 || .|||...  .  ||.||.   .. ..|| .| . .|.
lkchkywpstdqpaaygvltvslkkkeefsdytvrslllsk