Gene PTPRG in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRG
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP075_AA protein Get Run
SpurP075_AA_634-915 phosphatase_domain Get Run
SpurP075_AA_926-1215 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 171-244 5.1e-14 45.4 Pfam-A 2-76 (85) alignment 
Range on Protein: 171-244
Range on HMM: 2-76/85.0
PPGEPKALKINSTSLVLSWLPS---DGPISNYSVSVRKGNYTSsWDLAVNQPPGASsEYTVYGLMPYEFYQFHVRAH
.|. ...  ..||||.||| |.   .|||..|.| .|. . .. ..  .. |. .. ..|. || |.  |.| |.|.
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.ewkeftvprttt.svtltgLkpgteYefrVqav
fn3 Fibronectin type III domain 269-350 4.6e-10 32.7 Pfam-A 2-85 (85) alignment 
Range on Protein: 269-350
Range on HMM: 2-85/85.0
PPGNVTVTTRGPFTIAVSWKPPPpnSINGVLQNYKVMVSPG-----SQVIKLGPSTLSTVITNRKPFTLYIVTIAVVNSANeTGPFS
.|.|..|. ... .. .||.||.  . .| ...|.| ...      .. ... ..| | ..|. || | | .... || |  .||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngag.egpeS
fn3 Fibronectin type III domain 364-444 9e-08 25.4 Pfam-A 2-85 (85) alignment 
Range on Protein: 364-444
Range on HMM: 2-85/85.0
PPHGVIQVGKNPRSLQVFWNKPNLQNGKILFYYAYIRRRDSFF-WSRFKTSKQH--HLFLGLEVFTDYIIKVSASTNAGEGPNS
.|...   . ...||.. |..|. ..|.|  |    |  ..   | .|......  . . ||.  |.| ..| | ..||||| |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 457-531 3.9e-10 32.9 Pfam-A 1-77 (85) alignment 
Range on Protein: 457-531
Range on HMM: 1-77/85.0
SEPHNITITVIGPGTARISWMEPFIFYNSIDSYTVSYRDINVSTPMLAAEITNTS--RLLRNLQDDATYEVTVRAFT
|.|.|.... ... ....|| .|.     |..|.| ||. . . .     ...|.    |..|. ...||..|.| .
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavn
Syndecan Syndecan domain 574-610 4.8e-06 14.3 Pfam-A 16-44 (64) alignment 
Range on Protein: 574-610
Range on HMM: 16-44/64.0
AGRVVGVVFALFVLLglilgvlgFVILRMRKKDRMSF
|| |||..|| ...|        |.. ||||||  |.
aggvvgllfAvllvl........flvyRmrKKDEGSY
0050432 (Phosphotyrosine protein) phosphatases II 620-917 1.7e-99 328.3 In-house 12-302 (308) alignment 
Range on Protein: 620-917
Range on HMM: 12-302/308.0
TFCRPDDLEEPAIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLqplpGiPNSDYINANYIDGF--NR
...|....    ...|  . . .  .|.. |.. .|.||...|..... .... .||| ||||..|. ||.||| |    . ..||||||.|.||.  ..
llfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgysskl

QKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAK--GTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKhgkvPERRVYHF
....||||| |..|..||||.||||.. ||||.|||.|.|| ||..||| .  |....|. . |||   |....||.||. |..  ..    ..|.|.||
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg....esrtvthf

HYTDWPDHGVPPYTLPVLSFIQRSSAANptDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
|||.||||||||.. ..|.|...    .  . |||.||||||||||||.|..|..| |...| .|.||. .|..|.||.. |||.|||.|....|||.|.
hytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

AG
  
lk
0039614 (Phosphotyrosine protein) phosphatases II 622-918 1.2e-91 302.6 In-house 4-293 (297) alignment 
Range on Protein: 622-918
Range on HMM: 4-293/297.0
CRPDDLEEPAIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSfpATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGI-PNSDYINANYIDGFNR-QK
.|.  || . |..| .. ..   .||| ... .|.||.. .. .   ...  .||| ||||..|. ||.||| |.|..|  ..||||||.|.||... ..
lrdallesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr

AYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRrKCDRYWPAKGTpeRYNELEVTLELKEKFASYTLRTFLLKHrhkkHGKVpeRRVYHFHYTD
..||||| |. |..||||.||||.. ||||.|||.|.|| ||..||| .|.  .|... |||   |. . ||.||. ...    .|..  | |.||.||.
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn....nges..rtvthfqytg

WPDHGVPPYTLPVLSFIQRSSAANPT--DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
||||||||..  .|.|..    |. .  . ||..||||||||||||.|....|| |.. | .|.|.  .|..| ||.. |||..||.|..|.|||.|. .
wpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

N
.
l
subfamily_PTPRD_pd Subfamily PTPRD 630-937 5.7e-135 446.1 In-house 3-304 (564) alignment 
Range on Protein: 630-937
Range on HMM: 3-304/564.0
PAIHISKFESHVIACHANSDGGFAAEYEEIQHVpTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALK
..|.......||   .||||  |  ||..|..  ..|. . ..  .|| |||| ||| ||.||| |....| ..||||||..|||....|||||||| |.
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

TTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGtPERYNELEVTLELKEKFASYTLRTFLLkHRHKKHGKvpeRRVYHFHYTDWPDHGVPPYT
.|..||||.||||.| .|||.|||||.|. ||..|||.|| .|.|.||.|||| .|..| |..||| | ...|.. .   | | .||.|.||||||| ..
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkksses...reVrqFhFtsWPdhgvpesa

LPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQY
 ..|..|....|.|..|||||.||||||||||||.|||| ||.....|..|......|..|.|||..|||||||.|||...|| | .||| |.| .|.| 
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqh

VDRMTLPD
.....  .
lqkLaeve
0051299 (Phosphotyrosine protein) phosphatases II 630-914 1.7e-104 344.6 In-house 3-286 (288) alignment 
Range on Protein: 630-914
Range on HMM: 3-286/288.0
PAIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALK
 .|........| . .||.  |...|.||.... .... .... .||. ||||..|. ||.||| |..|.|...||||||.||||.|.....||||| |.
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

TTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAkGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVPERRVYHFHYTDWPDHGVPPYT
.|..||||.||||.. ||||.|||.|.||.||..|||  |... |... |||   |....||.||. ... .  .|.  .|.|.|||||.|||||||...
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

LPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
 ..|.|...   |.. . ||..||||||||||||.|..|..| |...|..|.|....||.|.||...|||.|||.|....|||.|
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 630-932 5.1e-88 290.1 In-house 2-304 (307) alignment 
Range on Protein: 630-932
Range on HMM: 2-304/307.0
PAIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALK
.||.| . |. . . . ..| |.| |||....  ..  ...|   ||.||||| .|...|. || |....|  .||||||..| |.. .| .|| |. . 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

TTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKgTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVPE-RRVYHFHYTDWPDHGVPPY
.| .||||...||.. .|||...|.|  |.||..|||   .  .|... |.|  .||   |. |.. . . ... |.|.. |.|  .||| |.|  ||  
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPev

TLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQ
.  .| .|..    . .. .||.|||||||||.|... .| .|.|..||.||..| . | .| ||| |||  |||||..  ||..   |.| ..  .| .
argllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

YVDR
 ..|
aier
subfamily_PTPRK_pd Subfamily PTPRK 630-937 2e-87 288.0 In-house 2-301 (314) alignment 
Range on Protein: 630-937
Range on HMM: 2-301/314.0
PAIHISKFESHVIACHANSDGGFAAEYEEIQHVptsfpATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALK
|||..     ..   ...   ||  ||| .           . . ||. |||...|..|| ||| |... | |.||||||..||...| .|.|.||| |.
pairvadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

TTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPerYNELEVTLELKEKFASYTLRTFLLKHRHKkhGKVPERRVYHFHYTDWPDHGVPPYT
 |  ||||||.....  |||.|.| | || || .||| ...   |....|.|   |  | .  |.| ... ..  |.   | | .|... ||||.|| . 
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklar..gqeeirevrqfqflgWpdhdvPvsa

LPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQ-
  .|....|  . .. .||.|.|||||| |||||.|.||..|  .. |. |.||   | .|...  .|.|||||.||.||.||   .|.| .  .|..  
tgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkal

YVDRMTLPD
|.. . |  
ylesirldp
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 630-913 8.8e-46 150.8 In-house 7-282 (290) alignment 
Range on Protein: 630-913
Range on HMM: 7-282/290.0
PAIHISKFESHVIACHANSDGGFAAEYEE-IQ-HVPTSFPATFSSDVEN-KLKNRYTNIVSYDSSRVSLQPlpGIpNSDYINANYIDGFNrqKAYIATQG
 ...   ||         .  ..| || | .. ..|. .      | .    |||| ..|  | .|| |.   |  . ||. |||..| .    .| |||
hsvqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd..Gy.dGdyvhanyvkGlk..amfiltqG

ALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAK-GTPERYNELEVTLELKEKFASYTLRTfLLKHRHKKHGKvpERRVYHFHYTDWPDHGV
||| |  |.||.| ..|  .|||. .| | |. ||..|.| | |    . |. |.  ....  . . .  .|  |.|. ||  | ...|..   |||. |
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikk.tlsvrdkdsGk..ehklkhlkikswpdksv

PPYTLPVLSFIQRSSaanpTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
.  || .|  ..       . .||..||||||.|||||.. |.. |. .    .... .  . .|  |   || . ||. . ..||..
alstlallrtlrilr....kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_PTPRB_pd Subfamily PTPRB 631-917 6.3e-105 345.4 In-house 6-288 (293) alignment 
Range on Protein: 631-917
Range on HMM: 6-288/293.0
AIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKT
 |...|||.||   .|.|| .|. ||||...| ..   ....  .|. |||||||..|| ||| |..| . ..|||||||||.|.| .. .||||| | .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHrhkkhgKVPERRVYHFHYTDWPDHGVPPYTL
|.|||||.|||.|| .|||.|.| |.|. ||..||||. .|  | ...|||  .|.   ...|......      .  ||.| ..|.| |||||||  | 
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek......ekeerkvrqyhftsWpdhgvPektk

PVLSFIQRSS--AANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
..|.|...    . . ....||.||||||||||||.| .|..|.... |. |..||.. ..|..||.|||||.||.|||...|. || .
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 631-931 1.8e-103 340.9 In-house 4-300 (319) alignment 
Range on Protein: 631-931
Range on HMM: 4-300/319.0
AIHISKFESHVIACHANSDGGFAAEYEEIQHvPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKT
 |.. ...... | ..... ... |...... ....  . .|  ||| ||||.||..|| .|| |..|.|...||||||..|||.......||||. |..
eievqeLkerlkalastgetllekefkllke.avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPaKGTPERYNELEVTLELKEKFASYTLRTFLLkhrHKKHGKVPERRVYHFHYTDWPDHGVPPYTL
|..||||.|||..| ..||.||| |... |. .||| . ..|.| .| |||| .|. . |  | . |   .|| ..|  |.| ||.||.||||.|| ...
tiedfWrmvWeeessivvmltklveklkvklkkywp.eenfeeyGrlivtleeeeeledyiirklkl...nkkssevetRevkhfqyteWpdhdvPekat

PVLSFIQRSSAAN-PTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQY
 .| ...|   .   |..|||.||||||||||||.||.| || ... |. ..|| . .|.||||| .||..||| ||...|||.. ||.| ..  .||. 
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdr

VD
. 
lk
subfamily_PTPRA_pd Subfamily PTPRA 631-933 1.8e-95 314.6 In-house 13-314 (330) alignment 
Range on Protein: 631-933
Range on HMM: 13-314/330.0
AIHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKT
 . . |.|  .    |.    |  |.. .   |       .|  ||| |||. ||. || ||| |... |...|||||| .|||..... .||.|| .. 
plpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee

TFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVPERRVYHFHYTDWPDHGVPPYTL
| .||||..|||||  |||.|.|.|| . || .||| .|.   | .. |..| ..   .||.| ||...  ..  . ..| |  ||.| ||| |||  . 
tvedfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepi

PVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYV
 .|.....  . |.  ||||.||||||||||||.||.|..|....||.||.||.|.||.|.||  .|||.|||.||. ||||.   |.| .. . | ...
GmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhl

DRM
...
qkl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 631-726 3e-20 66.2 In-house 4-95 (95) alignment 
Range on Protein: 631-726
Range on HMM: 4-95/95.0
AIHISKFESHVIACHANSDGGFAAEYEEIQHVpTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQplpGIPNSDYINANYIDGFNRQKAYIATQG
 ||.| | |||.  |.|||  |  |.  |.   .  | |  |   |  |||. ||. ||..|| |       .|||||| ..||. |...|||.||
pihvsvfhshvlemhsnsdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaqg
subfamily_PTPRG_pd Subfamily PTPRG 632-929 4.8e-146 482.2 In-house 1-302 (563) alignment 
Range on Protein: 632-929
Range on HMM: 1-302/563.0
IHISKFESHVIACHANSDGGFAAEYE--EIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNS-DYINANYIDGFNRQKAYIATQGAL
.....|..||...||..| ||..|.|  . ........|..|.. ||| ||||.|||.||.|||.|.||||. .. ||||||||||....||.|||||.|
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

KTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAkGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKV--PERRVYHFHYTDWPDHGVP
|.|||||||..|||.. .|||||.|.||||||||.|||.  ..|.|..|.|||. .|..|.|| ||. .|....|..|    |..|...|||.|||||||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

PYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTEL
 ..||||.|...|||||...||||.|||||||||||||||.||.|||.|.|..||||||||.||.|||.||||||||.|.||.|||......| ......
ehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv

RQY
.. 
eel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 632-948 6.7e-115 378.5 In-house 2-315 (318) alignment 
Range on Protein: 632-948
Range on HMM: 2-315/318.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTT
|.....||||   ... .  . .|||...... .. .. | .  || ||||.||..||..|| ||.| | ..|||||||||||..|.|||||.|. |  |
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLP
..||||.||||.| ||||.|..||||..|..|||| ||. . |..| |.|. . ....|.||.| ........    .| |  .|||.|||.|||  .  
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrteeee....srqvrqyhytsWpdegvpesgas

VLSFIQRSSAAN-PTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYV
.|......|.|. ...||||.|||||||||||..|..|..|....||. |.||.. |..|.||| .||||.||.||.||||| | .|.| |....||. .
lldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsri

DRMTLPD-EVGRVVLDEQF
 ... .| |.|.  .| .|
relreqdpesgttemdaef
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 632-914 2.3e-94 310.7 In-house 4-279 (288) alignment 
Range on Protein: 632-914
Range on HMM: 4-279/288.0
IHISKFeSHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTT
||||.  ..|.  .|..  ||  ||. .  .  .   | ..  .|. |||| ||..||  || |. |.  ...|||||.|||| ...|.|||||| |  |
ihispv.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladt

FDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKhrhkkhGKVPERRVYHFHYTDWPDHGVPPYTLP
 .|||.||.|.|.  |||.|.| |.|..||..|||....|..| ...|||  ...  ...||..||.       |  |... ...|. |||||||  . |
vndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle......kkkteleitqyqylaWpdhgvPeskap

VLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
.| ...    ||. |.||||||||||||||||.|..|........|....|.|.....| ||. ||||..||.||..|||.  
llellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 632-933 1.3e-92 305.3 In-house 4-302 (305) alignment 
Range on Protein: 632-933
Range on HMM: 4-302/305.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFpaTFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTT
| ........   ...|| |. |.|..... ..|.     .. .|| |||...|. .| .|. |.. .  ..||||||.|.||..|.|.||..|| ||.|
ialddlaayikearvysdkgleaqykslyeeeesi..dvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

FDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTP-ERYNELEVTLELKEKFASYTLRTFLLKHRHKkhgKVPERRVYHFHYTDWPDHGVPPYTL
 .|||||..| | ..|||.||| | |. || .||| . |  ....|..|.|. ..... |. | . .  ...   .  .| | ... ||||||||| .. 
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede...dkesrtvlqyqltdWPdhGvpqfat

PVLSFIQRSSAANPTDAG-PIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQY
 .||.|.|   .   | | |..|||||||||||..|..| .| ....|| |.||. ||..|..| ..||| .||||.||.| | . .|.| .    ||  
sllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar

VDRM
|...
vnkl
0043336 (Phosphotyrosine protein) phosphatases II 632-914 1.6e-92 305.2 In-house 2-277 (278) alignment 
Range on Protein: 632-914
Range on HMM: 2-277/278.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPTsFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTT
|...... ... ...|.  .. .|.||...... .. ...  .||| ||||..|. ||.||| |..|.| ..||||||.|.||.|.....||||| |. |
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPakGTPERYNELEVTLELKEKFASYTLRTFLLKHrhkkHGKVPERRVYHFHYTDWPDHGVPPYTLP
..||||.|||... .|||.|.|.|.|| ||..|||  |....|... |||   |... ||.||. ...    .|. ..| |.|.||..|||||||. . .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtn....lgdgesrtvthyhylgwpdhgvpeslsl

VLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
.|.|...   |.... ||..||||||||||||.|.....| |.. | .|...  .|..|.||   |||..||.|....|||.|
lldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 632-914 2.1e-92 305.4 In-house 9-304 (307) alignment 
Range on Protein: 632-914
Range on HMM: 9-304/307.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPT--SFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGI-PNSDYINANYI--------DGFNRQKA
| . |....|   ....  |...|.|....| .  ... .... .||| ||||..|. ||..|| |..|.|  ..||||||.|.        ||......
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

YIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHRhkkHGKVPERRVYHFHYTDW
.||||| |. |..||||..|||.. ||||.|.|.|.||.||..||| .|..  |... |||  .|. ..||.||. ...    .|. ..|.|.|||||.|
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl...dgtgesrtvthfhytgw

PDHGVPPYTLPVLSFIQRSSAANPT--DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEK---VNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|||||||.. ..|.||..  .|. .  . ||..||||||||||||.|....||.|...|..   |...  .|..| ||   ||..|||.|....|||.|
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 632-917 7.6e-74 243.2 In-house 2-286 (290) alignment 
Range on Protein: 632-917
Range on HMM: 2-286/290.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPN--SDYINANYIDGFNRQKAYIATQGALK
| ..||  .|.  ||. . || .... ..    .. .|     .|||.||..||| ||  |. |.|..| ..   .|||| ||.|.. .|.|||||| ..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

TTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPErYNELEVTLELKEKFASYTLRTFLLKHRHKKhgkVPERRVYHFHYTDWPDHG-VPPY
 |  |||.|.|..|. .|||.|.  | |. ||  |||...| . |.| ...|   |.. .|. |.. .|.....    ... | ... | |...| |. .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsa...gakqsvtqyqitnwdstgkvtnp

TLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
.  .|.. ..      .  ..|.||||..|||........| ..... |  ..||  ||. |.|.  .|||..|| .|....|. |   
qtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 632-922 4.5e-67 221.0 In-house 2-286 (287) alignment 
Range on Protein: 632-922
Range on HMM: 2-286/287.0
IHISKFESHVIACHANSDGGFAAEYEEIQHVPT-SFPATFSSDVENKLKNRYTNIVSYDSSRVSLQplpgIPNSDYINANYIDGFNRQKAYIATQGALKT
| ..||   |   ||... ||   .  ...|       | .   .|| |||.|.|. .|  || |.      . ||||| .|||.. .||.|.... .  
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvPERRVYHFHYTDWPDHG-VPPYT
|  .||.|.....  .|||.....|  ...| .||| . .   . | ...|  .|. |.|. |.. .|...|.    ....|  ...|.|...| |. . 
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkag...dkqqvkqyqitnWdstgkvtepq

LPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVK
  .| . ..  .      ..|.||||..|||..... ..| ... . |  ..||  ||. | |.   ||| ||| || |..|| | ...| ..
tillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 633-925 2.1e-66 219.3 In-house 6-299 (325) alignment 
Range on Protein: 633-925
Range on HMM: 6-299/325.0
HISKFESHVIACHANSDGGFAAEYEEIQHVpTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTF
 . ..  ||   .|. . ||| |.. .  .  .   . .   ||| |||. |.|..| ||| |. .   |.||||||.|.  . ... ..|.|  | .| 
avvnlvehvekkkaqdqdgfahefgllpsd.dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

DDFWRLVWEQKSVVIVMITKLEErGRRKCDRYWPAK-GTPERYNELEVTLELKEKFASYTLRTFLLKHRHKkhGKvpERRVYHFHYTDWPDHGVPPYTLP
.|.|||| . .. |.|.. .|.. |  .|  ||| . |   ..  ||| |   |... |  | . .|  .|  |.   | |  |..  |.| ||. .   
ndlWrlvldWrcsvvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk..Ge..trsvkqfqlqswddmGvqkrpat

VLSFIQRSS------AANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTE
..|..|          ||   ..||.|||||||||||..| . ..|...  | .|..|||.|..| .|  .|.| .||..|.. | | . .||| |  . 
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvss
subfamily_PTPN9_pd Subfamily PTPN9 634-914 1.9e-81 268.4 In-house 3-290 (297) alignment 
Range on Protein: 634-914
Range on HMM: 3-290/297.0
ISKFESHViacHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFD
|......|   ...   |   ||.||.. |..  .. |    |  |||||... ||..|| |. ... ..|||||||..||....||.|||||.|| |..
ieelvayv...kekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWRLVWEQKSVVIVMITKLEERGRRKCDRYWP-AKGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPV
||||.||||. .||||.|...||||.|| .|||  ... ... .|.|.    |.   |. |.. .|. ....    .|.| || .. |||.|||  .  .
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee....srkvthfqflsWPdyGvPssaasl

LSFIQRSS-------------AANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
| ...                 . ...  ||.||||||.|||||.| .|  |.... ...|.|.  .|..|||| . .||.|||.| .  .||. 
ldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 635-949 1.9e-82 271.7 In-house 9-315 (315) alignment 
Range on Protein: 635-949
Range on HMM: 9-315/315.0
SKFESHVIACHANSDGGFAAEYEEIQHVpTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDD
 .. ..|   .|..  ||  .|| |      .|   . ..||| |||| ||..|| ||| |  |   |.|||.|||.|||.|... |||.|| . .. .|
dqlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkd

FWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKgtPERYNELEVTLELKEKFASYTLRTFllkhrhK--KHGKVpeRRVYHFHYTDWPDHGVPPYTLPV
|||||.|..   |||.|.| |. .||...||| |     | .. ||.  .|..  || ||.            ..  | |. .||| ||| ||| ||.|.
fwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl......svvfgdni..revvqlhytswpdmgvpkytipl

LSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVK-STELRQYVD
. .|..    . ...|.|.||||||||||||.| .|..|.|..||. ..|. |....| .|  .||. ||| ||.|.||| . .|.| .     | .|  
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryds

RMTLPDEVGRVVLDEQFN
 ..   . |  .|.|||.
llapspdtgstllqeqfe
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 635-928 1.6e-68 226.1 In-house 5-293 (439) alignment 
Range on Protein: 635-928
Range on HMM: 5-293/439.0
SKFESHVIACHANSDGGFAAEYEEIQHVPTS--FPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTF
..|. ||   . | .  |  ..|.|. .       |.. ..  .. |||| .....| .|| || .||.| | |||||||.|.  .| ||||||  | | 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

DDFWRLVWEQKSVVIVMITKLEERGRrkcdrYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKvpERRVYHFHYTDWPDHGVPPYTLPV
|||||||.|.|.| |||.|.| |  .     |||...    | .. |  . . ..  |..| | .  .. .  |  || | .|||. |||. ||  .  |
ddfwrlviekktvtivmltnlvesyk.....ywpsdae.vcygdiavrvdrnielpnyvirgfkvfnerdttek..ertvlqfhyiawpdknvpaqashv

LSFIQRS-SAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQ
| |..   || .  . ||..|||||||||||| | .|  |.|...|.||.. | .| .| ||. .||.  |||||.. .|| .  |.. |   |...
ldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
0040438 (Phosphotyrosine protein) phosphatases II 636-943 5.1e-98 323.5 In-house 4-305 (317) alignment 
Range on Protein: 636-943
Range on HMM: 4-305/317.0
KFESHVIACHANSDGGFAAEYEEIQHVPTSfPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDF
... ..  ..... ...  |.|...... . . .... .||| ||||..|. ||.||| |.||.|...||||||.|.||.|.....||||| |. |..||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRLVWEQKSVVIVMITKLEERGRRKCDRYWPAkGTPERYNELEVTLELKEKFASYTLRTFLLKHRhkkhGKVPERRVYHFHYTDWPDHGVPPYTLPVLSF
||.||||.. ||||.|.|||.||.||..|||  |..  |... |||   |. |..||||. ...     |. ..|.|.|||||.||||||||.. ..|.|
wrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl....gdsesrtvthfhytgWpdhgvppspdllldf

IQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYVDRMTL
...  .|.. . ||..||||||||||||.|....|| |.. |..|.|.  .|..| ||.. |||.|||.|..|.|||.|. ..| .  .||  ...... 
leavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli

PDEVGRVV
|. ...| 
plalddvk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 636-919 1e-60 200.0 In-house 4-298 (301) alignment 
Range on Protein: 636-919
Range on HMM: 4-298/301.0
KFESHVIACHANSdggFAAEYEEIQHVpTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPG--IPNSDYINANYIDGFNRQKAYIATQGALKTTFD
. ..||.|.|.|.   |...|.|.... .. ..| . . |||  ||. ||. ||  |. |.| |   . . .||||.||||....|..||.|| .| |  
dlgthvaakhsnk...feeqykelkeg.edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlv

DFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPA-KGTPERYNELEVTLELKEKFASYTLRTFLLK-----------HRHKKHGKVPERRVYHFHYTDWP
|||||.|..| | |||.|.|.|. . || .|||  . . |.. ...|||  .  . ....| . .|           .. |.. .   . |  .. ||||
dfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWp

DHGVPPYTLPVLSFIQRS-SAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNT
..|| .    ||  |.    . .  . ||..||||..|.|.|.|. ..  | | .||  |.||.  |..| ..   |.| |||..|.||. ..|.  .|
qdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 639-915 9.4e-83 272.5 In-house 4-277 (281) alignment 
Range on Protein: 639-915
Range on HMM: 4-277/281.0
SHVIACHANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRL
 |. . ..|.. ||. |||..... .. .|| |   ||.|||||.|||.|| .|| ..|     |.||||||...|.. .|.|||||| . .....||..
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

VWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLkHRHkkhgKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQR
|||||  .|||.|.  | |. || |||| . .  .| .. |. . .|. |.|  |.| | .|.    . ..|.| ...|| |||||||  |  .|.| . 
vweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.ere....sgetreveqlaytaWPdhGvPattkellefrke

S-SAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAE-EKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
  .. ..    |...||||||||||||| .|...|...|| |...|   .. .| .||..|||  || |.. ..|. | 
vlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 641-920 4e-37 122.4 In-house 18-296 (310) alignment 
Range on Protein: 641-920
Range on HMM: 18-296/310.0
VIACHANSDGGFAAEYEEIQHVPTSfPATFSSDVENKLKNRYTNIVSYDSSRVSLQpLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVW
.||       |.. .|  ..    |   |. .  ..  ||||...|  |.||| |. .      ||| |||.     ....| .|| |. |  ||||...
iiateklgieglvkqyrkldakqds.sltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmif

EQKSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTL--ELKEKFASYTLR-TFLLKH--RHKKHGKVPERRVYHFHYTDWPDHGVPPYTLpvLSF
....  |... |  | || ||  |||. |  | |  . ||   |  |.|    |  ||.       ..  .. | ||   .. .||| |||       . 
qeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htv

IQRSSAAnpTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTV
 ||  |      || .||||||..|... . ..  .....  .||..      .. .|   .||| ||..|. | . . |. . |
pqrllaq..vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargetev
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 644-921 6.1e-91 299.8 In-house 21-297 (298) alignment 
Range on Protein: 644-921
Range on HMM: 21-297/298.0
CHANSDGGFAAEYEEIQHVPT---SFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVW
 ....  |.|.|......|     ..  . ..  ||| ||||..|...||||| |.   .  .|||||| .........|.||||. |..|. ||||.|.
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EQKSVVIVMITKLEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKhgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSS
|... .|||.|.||| .. |. .||| .|. |.|.|..|.|  ||.|| .. |.. .......     ||.| ..|.| |||.||| ..  || ....  
eedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkee....kerevrqlhftsWpdkgvpenatsvldllrkvr

AaNPTDAG--PIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVV
| ....||  |.||.|||||||.||.|.||..| ....|..| ||  .|..|..|  .||||||||||... || | ..|. .
a.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0036941 (Phosphotyrosine protein) phosphatases II 645-922 4.1e-94 310.5 In-house 8-285 (297) alignment 
Range on Protein: 645-922
Range on HMM: 8-285/297.0
HANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLqplPGiPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKS
....  ..  |.||....  ... . .. .||. ||||..|. ||..|| |   .. ..||||||.|.||.......||||| |..|..||||.||||..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

VVIVMITKLEERGRRKCDRYWPAK-GTPERYNELEVTLELKEK--FASYTLRTFLLKHRHKKhgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSA
 ||||.|.|.|.|| ||..||| . | .  |... |||   |.  ...|||||. ...  ..    ..|.|.|||||.|||||||... ..|.||..   
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng....esrtvthfhytgwpdhgvpespaslldfielvrk

ANPT--DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQ---AEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVK
...   . ||..|||||||||.||.|..|.|| |..    |..|... ..| .|.||.  |||.|||.|....|||.|. ..|.. 
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep
0047943 (Phosphotyrosine protein) phosphatases II 645-914 5.9e-93 306.5 In-house 7-272 (273) alignment 
Range on Protein: 645-914
Range on HMM: 7-272/273.0
HANSDGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLqplpGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKS
.... .....|.|... ...... .... .||| ||||..|. ||.||| |    | ..||||||.|.||.|.....||||| |. |..||||.||||..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

VVIVMITKLEERGRRKCDRYWPAKGT--PERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAA
 ||||.|.|.|.||.||..||| .|   ...|... |||   |....||.||. |.. . ..    .| |.|||||.||||||||.. ..|.||.    |
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge....srtvthfhytgwpdhgvppslesllefielvrka

NPT--DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
. .  . ||..||||||||||||.|..|..| |...| .|.|.  .|..|.|| . |||.|||.|....|||.|
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN23_pd Subfamily PTPN23 647-915 1.1e-57 190.1 In-house 12-281 (288) alignment 
Range on Protein: 647-915
Range on HMM: 12-281/288.0
NSDGGFAAEYEEIQHVPTSFPATFSSDV--ENKLKNRYTNIVSYDSSRVSLQplpgIPNSDYINANYIDGFNRQ-KAYIATQGALKTTFDDFWRLVWEQK
.  ... ....|...        .|  .   .  |||...|. ||..|| |.      . ||||| .. .   .   .||||. |..|  |||..|.|||
dgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

SVVIVMITKLEERGRRKCDRYWPA-KGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSA-
| ||||... ||.|. |.|||||. || ......|.|||. ...   .  |.. |.......     . | | ..| ||..|||     .| |..   . 
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldada....vksvshlqltsWpelGvPasPetllqfldevesa

----ANPTDAgPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKV-NVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
     ..... |..|||||||||||.. .. . ........ . ..   ..|.|.|| . ||..||. |  .. ||  |
yeavqrkskt.PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_PTPN6_pd Subfamily PTPN6 648-920 1.5e-86 285.2 In-house 24-303 (306) alignment 
Range on Protein: 648-920
Range on HMM: 24-303/306.0
SDGGFAAEYEEIQHV--PTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQpLPGIPNSDYINANYIDG--FNRQKAYIATQGALKTTFDDFWRLVWEQK
.  ||  |.||.|.    . .  . .. .||| |||| ||. .| .||.|.  |..|.|||||||||..   . .|.||||||.|.||  ||||.||...
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

SVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHRhkkHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQR----S
| ||||.||  |||. || ||||.. . |.| ...||   ... |.|.||.......   . |  ||.|...|...|||||||  .  ||.|..     .
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk...kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq

SAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQA---EEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTV
.  . ..||||.||||||.|||||.||||..||...    . ....  . | .|.||. |||||.|| |.. .. ..... ...
eeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkkl
subfamily_PTPN14_pd Subfamily PTPN14 649-915 2.9e-63 208.6 In-house 22-297 (300) alignment 
Range on Protein: 649-915
Range on HMM: 22-297/300.0
DGGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIpNSDYINANYIDGF--NRQKAYIATQGALKTTFDDFWRLVWEQKSVV
.|   .|||.|..  .    . ..  ||. |||. ... |. .|| |.|     ...||||  |      ... ||..|| |..|  |||..||||.  .
egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IVMITKLEERGRRKCDRYWPAKGT---PERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRS----
|||.|. || |. |. .|.| ..      .... .|| ...|.  |.. ... |||   |.    || |.|. ||||||||||.   . ||....     
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske....ertvwhlqytDWpdhgvPeDvkgflsyLeevqsvr

---SAAN-P-TDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
   .  . .     |..|||||||||||  |. | ... .. .|....   |.|.|.|| .||||  || |...||...|.
rktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0045098 (Phosphotyrosine protein) phosphatases II 650-917 9.2e-81 266.5 In-house 7-275 (278) alignment 
Range on Protein: 650-917
Range on HMM: 7-275/278.0
GGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSlqplpgipnsDYINANYIDGFnrQKAYIATQGALKTTFDDFWRLVWEQKSVVIVM
. .  |.|.. . .     |..  ..|. ||||..|. ||.|||           |||||.||||.  .|..||||| |..|..||||..||... ||||
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

ITKLEERGRRKCDRYWPAkGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVPERRVYHFHYTDWPDHGVPPYT--LPVLSFIQRSSAANPT--
.|.|.|.|| ||..|||  | ...|....|||.  | .  |||||.|. . . ..   ..| |.|.||. |||||||...   ..|.....  .|. .  
ltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealklla

-----------DAGPIIVHCSAGVGRTGTYIVIDTMLKQMqaEEKVNVFGFLKRIRTQRNY-LVQTEEQYVFIHDVLLEWLRAG
           . ||..||||||||||||......||...  |..|...  .| .|.||..  ||..|||.|....|||.|. |
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPN3_pd Subfamily PTPN3 650-911 1.8e-71 235.3 In-house 15-272 (280) alignment 
Range on Protein: 650-911
Range on HMM: 15-272/280.0
GGFAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPlpgiPNSDYINANYI----DGFNRQKAYIATQGALKTTFDDFWRLVWEQKSV
|   |..|..     .   . .   ||  |||| .|..||. ||.|.      ..|||||||.    .. .  . |||||| |..|  |||..|||||| 
Gavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss

VIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPT
.|||.| | |||| || .||| ..   .| |..|..| ...  || || ..||....|.    ||.. .. |..|||||||  .  .|.|..|  ..  .
livmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketke....erkilqlqylaWpdhgvPddsadflefvervrklrsg

DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLL
.  |..||||||.|||| .|...| |  ..|.|.|..   ....| ||  ||||..|| |. . .|
keePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 650-913 5.5e-50 164.8 In-house 6-258 (267) alignment 
Range on Protein: 650-913
Range on HMM: 6-258/267.0
GGFAAEYEEIQHVPTSFPA-TFSSDVENKLKNRYTNIVSYDSSRVSLQPlpgiPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIV
  .  |.|.|... .     . |   .|. .||. . . || .|| |.      . .|||| |..|.....|.|.||..|| |  ||. .. .||  |||
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MITKLeerGRRKCDRYWPAK-GTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVperrvYHFHYTDWP-DHGVPPYTLPVLSFIQRSSAANptD
..||    .  .  ..|| | |  ..|..| |   |...   | . |. || . .   .|       ..|  |  .    ||  |..  . .    |   
lltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnv.....tlyyykkwnintnnkpylkplfgilaknqlen..g

AGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
  |..|.||.||||.||..|||..|.... |. ...| ||..|| ||  ||.| |.|..||..| |.
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0046845 (Phosphotyrosine protein) phosphatases II 651-919 1e-95 315.7 In-house 1-279 (284) alignment 
Range on Protein: 651-919
Range on HMM: 1-279/284.0
GFAAEYEEIQHVPTSF--PATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPG-IPNSDYINANYIDGF-----NRQKAYIATQGALKTTFDDFWRLVWEQ
|. .|.||.... ...  . ...  .||. ||||..|. ||.||| |..|.| ...||||||.|.||.     ...|..||||| |..|..||||.||||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KSVVIVMITKLEERGRRKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHRHK-KhgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSA
.. ||||.|.|.|.|| ||..||| .|.. .|... |||  .|.. .||.||. |.. .  .    ..|.|.|||||.||||||||.. ..|.|..    
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytg....esrtvthfhytswpdhgvppspedlleflrlvre

ANP--TDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEE---KVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNT
...   . |||.||||||||||||.|..|..|.|...|.   .|.|.. .||.|.||.. |||.|||.|....|||.|. ..|
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 651-949 3.3e-73 241.3 In-house 20-313 (315) alignment 
Range on Protein: 651-949
Range on HMM: 20-313/315.0
GFAAEYEEIQHvPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMI
 |. |. ..   |  .. . . . .|  |||| ||. .||.|| |. .  .|.|||||| || ... .|||||.|| ||.. |||||.|...|   |||.
lfseefhdlpd.PdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmv

TKLEERGRRKCDRYWPA-KGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKkhgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGP
||..|  . || .|||  |.   .. ...|.|   |  .  . | . ... ..       |.|  |..|.|||.||.  |  .| .|.   | | ..  .
tkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee......srtvtqfqftewPdkGvdkqtssllklikevkadngkkefs

IIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYV-DRMTLPDEVGRVVLDEQF
..|||||||||||  | || ...|.. .. |.|| |.| .|..| |||||||.| ||.|..|| |   ||...   . ... |  |  |  ||  . ..|
llvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkef

N
.
e
DSPc_SM00195 652-914 8.5e-90 296.0 In-house 2-262 (263) alignment 
Range on Protein: 652-914
Range on HMM: 2-262/263.0
FAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMIT
. .|.|...   .. . | .   .|| ||||.||. ||..|| |.. .. ..|||||||||.| |..|.|||||| |..|..||||.|||.|. .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLEERGRRKCDRYWPAK-GTPERYNELEVTLELKEKFA-SYTLRTFLLKHRHKkhgkVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGP
. ||.|..||||||| . |..|......|.|  .||   ...|||. |..  |      .|.|....|..|||||||  | .||....     . |  ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|.||||||||||||...||..|.....|.||..|  .|..|.||  .|||.||| ||....||..
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 652-914 8.5e-90 296.0 In-house 2-262 (263) alignment 
Range on Protein: 652-914
Range on HMM: 2-262/263.0
FAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMIT
. .|.|...   .. . | .   .|| ||||.||. ||..|| |.. .. ..|||||||||.| |..|.|||||| |..|..||||.|||.|. .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLEERGRRKCDRYWPAK-GTPERYNELEVTLELKEKFA-SYTLRTFLLKHRHKkhgkVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGP
. ||.|..||||||| . |..|......|.|  .||   ...|||. |..  |      .|.|....|..|||||||  | .||....     . |  ||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|.||||||||||||...||..|.....|.||..|  .|..|.||  .|||.||| ||....||..
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 652-932 2.8e-77 255.1 In-house 36-309 (319) alignment 
Range on Protein: 652-932
Range on HMM: 36-309/319.0
FAAEYEEIQHVPTSF-PATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMI
. .|.  . .....    ||.   .|| |||..||...| ..| |..| |.  |||||| ...|. |.. |||.|| |. | .||||..||...  ||..
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll

TkleergRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKvpeRRVYHFHYTDWPDHGVPPYTLPVLSFIQRSS--AANPTDAG
|      . || .||| |.  ..... .| ... |. | |..| . | .  |....   |..  ||.  |||.||| |. ... .... .       .  
t......kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdi...rkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra

PIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYVDR
.|.|||||||||||.|||.|..|..|. |..|.|. |.. .| ||| |||   || ||.  |||    |.. |   ..  |...
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpaylee
subfamily_PTPN1_pd Subfamily PTPN1 652-913 2e-61 202.2 In-house 8-270 (290) alignment 
Range on Protein: 652-913
Range on HMM: 8-270/290.0
FAAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPlpgiPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMIT
... |..|..  . ||.. . . ||. .||| ..  || ||. |.      . |||||. ..  . .. || ||| |  | | ||..||||||  .||. 
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikler....adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmln

KLEERGRRKCDRYWPAKGT-PER-YN--ELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQ--RSSAANPT
|. |... || .||| .    |  ..  .|.|.|  .|.   ||.|.. |. .. ..     | ..||||| ||| |||      |.|..  |.| .  .
kvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqe....treilhfhyttwpdfgvpespaaflkflfkvresGslss

DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEK---VNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
| || ..|||||.||.||....||.| .......   |..   |  .| .|  |.|| .|  | .  .|| 
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 652-931 1.1e-60 200.2 In-house 22-253 (392) alignment 
Range on Protein: 652-931
Range on HMM: 22-253/392.0
FAAEYEEIQHvPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMIT
|. |. ..   |  .| | .    |. |||| ||. |||.|| |. .  ||.|||.|| ||..|. .|||||.||   ...|||||.|....   |.|.|
ffeefhdlpg.pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

KLEERGrrkcdrywpakgtperynelevtlelkekfasytlrtfllkhrhkkHGKvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPII
||.|                                                .|.   | |  ||.|.|||..|| .|  .| ||.  .|     . |.|
klkegd..............................................kgd.dartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpli

VHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYVD
.||||||||||  | ||... . .    |.|| |.  || .| |.|||.||| ||.  .|| |   ||..    . ....
ihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 653-984 1.5e-76 252.6 In-house 21-351 (515) alignment 
Range on Protein: 653-984
Range on HMM: 21-351/515.0
AAEYEEIQhVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITK
. |. ..   |  .| | . .  |  |||| ||. |||.|| |. .   |.|||.|| || .|. .|||||.|| .|.. |||||||....   |.|.||
seefhdlp.gpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk

LEERGRRKCDRYWPA-KGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKkhgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPII
|.|  . || .|||   |   .. ...| |   |  .  . |.. . .  .       | |  ||.|.|||.|||. |  .| .|.   | .   . |.|
lkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd......srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpli

VHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYV-DRMTLPDEVGRVVLDEQFNL
.|||||||||| .| || .. ...  . |.|| |.. || .| |||||.||| ||....|| |   ||..    . ... |  .  |  ||  . ..|. 
ihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqt

IMKMKPRD----YEFSKARQSKHKNRDMDLIPVERSRV
.  . |         ...|... |||  . .|..|.||
lkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrv
subfamily_PTPN13_pd Subfamily PTPN13 653-915 8.6e-68 223.5 In-house 14-270 (273) alignment 
Range on Protein: 653-915
Range on HMM: 14-270/273.0
AAEYEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGipnsdYINANYIDGF--NRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMI
| |..|.... .   .. . . ||| |||| |.. || .|| |.   |     ||||..|     . .  |||.|| | .| .|||..|||||. ||.|.
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TKLEERGRRKCDRYWPAKGT--PERYNELEVTLELKEKFASYTLRTFLLKHRHKkhGKVpeRRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPtDAG
|.  |.|. ||.|||| .       .| |||.|.  .|  ....|.. .|. .   |..  |.| |.....|||||||  ....| |...    .  |||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses..ges..revahlnfvkwPdhgvPssaaellqfvaevrrlqt.dag

PIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
||.||||||.||.||.|.||..|  .. .....|   ....| ||. .|||..||.|.. ..|| |.
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 653-923 7.8e-67 220.5 In-house 26-293 (297) alignment 
Range on Protein: 653-923
Range on HMM: 26-293/297.0
AAEYEEIQHVPTS--FPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRqkAYIATQGALKTTFDDFWRLVWEQKSVVIVMI
  ..||.. .|..  .|.| . .  |  |.||.||. |||||| |. .   |.|||.|| .. |..    .|.||   |.| .|||..|....  .|||.
dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

TKLEERGRrKCDRYWPAKGTPErYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVperrVYHFHYTDWPDHGVPP--YTLPVLSFIQRSSAANPTDAG
....|| . || |||. ||. . . .. |.|.  ..   .  |.. ... . |  .|    |  .....|||. |.    .  .| .|.       . | 
nddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrv....vkqyqfveWPdkaverkdsassllklisevrkdfsqnae

-PIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKS
 |..|||.||||||| .. || .. ... |..|..||..|..| .| |||||.||| |.. ..|| | . .| ...
gPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 653-914 3.3e-52 172.0 In-house 13-277 (287) alignment 
Range on Protein: 653-914
Range on HMM: 13-277/287.0
AAEYEEIQHVPTSFPATFS--SDVENKLKNRYTNIVSYDSSRVSLQPLPGIpNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMI
 .|.. ...   | .|||    .. .  ||||.... .| .|| |   .    ||||||||. ......|.||.|| . .|  ||||.|.|..| .....
dkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm

TKLEERGRRKCDRYWPAKGTPERYNELEVT-LELKEKFASYTLRTFLLKHRHKKHGKVperrVYHFHYTDWPDHGVPPYTLPVLSFIQRS-----SAANP
|.  | .| || .||| .  | |     |. |. . |   |. |.. | . . .. .|    |  ... .|||....| .. .. |.         | . 
treveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearv....vkqldllswPdkvlaPtavglirfvldvkqhielarda

TDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
...||..||...|.||.|... . .......   .|.|   . |.| .|. |||.  |. .. . |  . 
sevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 653-916 8.2e-18 58.8 In-house 29-287 (302) alignment 
Range on Protein: 653-916
Range on HMM: 29-287/302.0
AAEYEEIQHVPTSFPAtFSSDVENKLKNRYTNIVSYDSSRVSLQPLPgipnSDYINANYIDGFNRQKAYIATQGALKTTF---DDFWRLVWEQKSVVIVM
 .|...|... ..     ..  .|  ||. ...  .|| .| |.  |     .|.||  ..  . ..  | .| . ...    ..|||.|...| | .|.
kkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvi

ITKLEERGRrKCDRYWP-AKGTPERYNELEVTLELKEKFASYTlRTFLLKHRHKKHGKVPERRVYHFHYtdWPDHGVPPYTLPVLSFIQRS-SAANPTDA
. . ||  .   . ..|   |. . |... |     ||    .   . .    .     .   ||....  |... ||     .   ..       ..|.
lvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakvfakkikade

gPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRA
 ....    |.|| |. ..  . ....|.....|.   .| ||.||   |.. .|||... .|| ... 
.ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 655-915 4.7e-38 125.4 In-house 16-270 (281) alignment 
Range on Protein: 655-915
Range on HMM: 16-270/281.0
EYEEIQHV-PTSFPATFSSDVENKlKNRYTNIVSYDSSRVSLQP-LPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITK
|. ..    |. . ..|   |.|| ||||.||   | ||| |.  .|    .||| ||||     .. || |||  | |  ||||..|....  |||. .
efsnlpgdppsdlctvfnqpvnnk.knrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

LEERGRRKCDRYWPAKGT-PERYNELEVTLElkekfaSYTLRTFLLKHRHKKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSfIQRSSAANPTdagPII
. |  | ||  |.| .     ....| |. |        |.   |.  | .   .   | . |. . .|||  ||  .  .|  | |   |  |   | .
fletnrekcaeyfprnahcclqfdklsvsye......dstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlk.ilrkirarst...ppv

VHCSAGVGRTGTYIVIDTMLKQMQAEEKV-NVFGFLKRIR-TQRNYLVQTEEQYVFIHDVLLEWLR
.||||||||.|| . ..  |. ...   . ..   . ..| | |   ||| .||..|  |||..  
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv
subfamily_CG42327_pd Subfamily CG42327 656-836 5.6e-32 105.7 In-house 8-187 (319) alignment 
Range on Protein: 656-836
Range on HMM: 8-187/319.0
YEEIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQ-KAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLE
.|| ...|     .    |  | |.|. |.|    .|| ||  .  ... |..|.|. |..     |||.| .|. .  ||||.||||.| ||| .|.| 
aeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

ERGRRKCDRYWPAKGTP---ERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGkvpeRRVYHFHYtDWPDHGVPPYTLPVLSFI
| | ..| .|.|.| |    . | .. |||  .|    | . |.|||. .|.      | . |. | .|.. .||    .... .
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkees....relthywy.kwleaevPaeeaaliaml
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 657-914 2.9e-47 156.2 In-house 20-277 (307) alignment 
Range on Protein: 657-914
Range on HMM: 20-277/307.0
EEIQHVPTSFPATFS--SDVENKLKNRYTNIVSYDSSRVSLQpLPGIpNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLE
.|.. .    | . .  .   |  ||||...   | .|. .. ..|.  |||| |||.    . | .|..|| |..|  .|| .. ..|   ..|. |. 
defrvlakktpegvtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvi

ERGRRKCDRYWPA-KGTPERYNELEVTLELKEKFASYT--LRTFLLKHRHKKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQrssAANpTDAGPII
| .. ||..|||. .|    . |   |. ...  |        ..     |       | . |. ...|||.|||.  |  . ...   | .  |  |..
elakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlle...avr.ydtnpvv

VHCSAGVGRTGTYIVIDTML-KQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|||||||||.|| . |  .  | .. ..  ..  ... .|.||.| .||| ||...| ||||..
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 658-915 7.2e-73 240.0 In-house 10-269 (274) alignment 
Range on Protein: 658-915
Range on HMM: 10-269/274.0
EIQHVPTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIP-NSDYINANYIDGFNR-QKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEE
|  ..|. |.    .   .. ||||..|.  . |||.|..  .   .|.||||||| |... .|||.|||| | .| .||||....... ||||.|||.|
eflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklke

RGRRKCDRYWPAKGTP---ERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGkvperrVYHFHYTDWPDHGVPPYTLPVLSFIQRS---SAANPTDAGP
. ..|| .|.| .      |||...|.. | . .   |..|...||. ....       |.|. ||||||| .|  . ..|....       .. . ..|
aneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers......vkhywytdWPdhksPddantlldlvleveesreeenaklap

IIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
..||||||.|||| .| |.  ..|...|..|.|..    .| .|  .|||.||| .|| .| ..|.
vvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 658-926 1.8e-56 186.1 In-house 14-278 (283) alignment 
Range on Protein: 658-926
Range on HMM: 14-278/283.0
EIQH--VPtSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGipnsDYINANYID---GFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITK
 ...  || . .|. .|  ||| |||. .||..|  || |....     ||||| .|      ...| ||..|. |. |  |||..|...| . |||.||
vlkrlsvp.dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

LEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKVPerrVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIV
| |  | || .||| .|. | | |. |||.      |.. . .||..    . ..    . |. . || . |  .    .. | .  |  .    |||.|
lqedlrikCsqyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssakstll...lahyqvidWleygeqaiinslvkfnkvislqteskkgPivv

HCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTEL
|||.|.|||...| . . .|....|  |.||  .| .| ||  .||| .|| ..|.. ||   .|.| .   .|
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl
0049772 (Phosphotyrosine protein) phosphatases II 662-921 4.1e-47 156.8 In-house 32-287 (314) alignment 
Range on Protein: 662-921
Range on HMM: 32-287/314.0
VPTSFPATFSSDVENKLKNRYTNIVSYDsSRVSLqPLPGIPNSDYINANYIDGFnrqKAYIATQGALKTTFDDF----------WRLV--WEQKSVVIVM
|....  .......|. ||||..|. .| .|| | |  .. .||||||.|.|||   ...||||| |. |..||          ||.|  ..... .|||
vlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------ITKLEERGrrkcdrywpAKGTPERYNELEvtlelkekfasytlrtfllkhrhKKH--GKVPERRVYHFHYTDWPDHGVP
                     ...| ..|         .  |.... .|.                       . .  .. .||..........||...|
srdevladelsrLdaAlgKtpllildgng.........neptaadlellk.......................eelydpelferlgikylripvpDgsap

--PYTLPVLSFIQRSsaanpTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMqaeeKVNVFGFLKRIRTQRN-----YLVQTEEQYVFIHDVLLEWLRAGNT
   . . .| ||..       . ||..|||.||.|||||..|.. ..|..    .|..   |...| .|       .... |||.||...|||.|.   .
lledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkk

VV
. 
fy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 662-914 4.3e-42 138.8 In-house 42-289 (305) alignment 
Range on Protein: 662-914
Range on HMM: 42-289/305.0
VPTSFPATFSSDVeNKLKNRYTNIVSYDSSRVSLQPLPgipNSDYINANYIDG-FNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRK
  . | |  |.|. .. ||||...   | | | |.  .    |||| |||.   .  .| .|..|| |  | |.|| .| ..|   |||. |  | |. |
tqvafnanqsadi.aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklk

CDRYWPAKGTPERYNELEVTLEL-K---EKFASYTLRTFLLKHrhkKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIqrsSAANpTDAGPIIVHCSA
| .||||     .     . .|             ..  ||.     .    .  | |...|.||| ||||  |  | ..   ||       ||.|||||
caqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnl...tysgdqkmsvrhlqwtewpdrgvppckltslell...sair.gskvpivvhcsa

GVGRTGTYIVIDTMLKQMQAEEKVN-VFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|.||||| . |. .|...  . ..  .  ..| .| || . .|.. ||.||| |.|...
gigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 662-921 4.2e-18 60.0 In-house 31-285 (303) alignment 
Range on Protein: 662-921
Range on HMM: 31-285/303.0
VPTSFPATF--SSDVENKLKNRYTNIVSYDSSRVSLQplpgipNSDYINANYIDgFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRR
| . .| .      |.|  |||.....  | |.| |       .| || |.|.. .. .|  | ||  |  |  |||... |||  .....    |  . 
vvsylppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydkl

KCDRYWPAKGTPERYNELEVTLelKEKFASYTLRTFLLKHRHKKHGKVpERRVYHFHYTDWPDHGVPPYTLPV--LSFIQ-RSSAANPTDAGPIIVHCSA
  |  .| .    ...|  . .   |         . ||      |.     ..  || .||   .|  . |       | .|   . .|. | .    .
ggdsvfprnqdflkfeersirv..gefkrvelgdgwvlkvlsvsngdy.ksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls

GVGRTGTYIVIDTMLKQMQAEE-KVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRaGNTVV
|.||.||. ...|    ...|.  ...   |. .|  | . ||   |. ... .| | .  .| ..
gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl.dngic
subfamily_PTPN12_pd Subfamily PTPN12 663-918 5.6e-77 253.5 In-house 27-281 (290) alignment 
Range on Protein: 663-918
Range on HMM: 27-281/290.0
PTSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCD
 . .... ..  ||. |||| .|. || ||| |.   . ..|||||||.| | . ...|||.|| | .| |||||..||..  ..||. .. | |. ||.
ekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCe

RYWPAKGTP-ERYNELEVTLELKEKFA-SYTLRTFLLKHRhkkhgkVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGR
|||| .|    ...|.||||| ....   ...||. ....        .|.|| ||||.|||||||  . ..|..|.     . ... |..|||||||||
rYWpeegeeelefgefevtleeekavdddflirtLkveaq......kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGr

TGTYIVIDTMLKQM---QAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGN
||| |.|| . ...   . .|...||  . ..|.||. ||||.|||....  ..| ...  
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 664-761 1.4e-12 41.8 In-house 22-118 (332) alignment 
Range on Protein: 664-761
Range on HMM: 22-118/332.0
TSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGipNSDYINANYIDGFNRQKAYIATQGALKT-TFDDFWRLVWEQKSVVIVMITKLEERGRRKC
 ..| |.   ..|   ||   .  .| ||| | |  |  . |. ||...||.... ||| .|  ..  |   |||.| |.|  .|...  ..|. .||.
mtypntydkflnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 664-716 1.8e-11 38.0 In-house 35-87 (440) alignment 
Range on Protein: 664-716
Range on HMM: 35-87/440.0
TSFPATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFN
 | |.  .|  .||.|||| ||..|| ||| |. . |.|.|||||| ||.| .
lsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingie
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 667-829 1.7e-35 117.4 In-house 22-183 (297) alignment 
Range on Protein: 667-829
Range on HMM: 22-183/297.0
PATFSSDVENKL--KNRYTNIVSYDSSRVSLQplPGIPNSDYINANYIDGFNRQK--AYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCD
. .|||   |    ||||..|...|..|| |.   .|...|||||.|.   . ..   || .|| |..| ||||.||.||   ||||..||.| || || 
gesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

RYWPAKgTPERYNELEVTLELKEKFA----SYTLRTFLLKHRhkkhgkVPERRVYHFHYTDWPDHGVPPYT
 |||     || .  .| .|   ...       |  . | .|        .| | |  .  |||||||   
pywpsv.vqerlkagdvvveflsstsdefdrviltelqliyr......sesrvvrhvqflswpdhGvpsdl
subfamily_egg_pd Subfamily egg 667-933 5.8e-29 95.7 In-house 31-287 (307) alignment 
Range on Protein: 667-933
Range on HMM: 31-287/307.0
PATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERgrRKCDRYWP
. | . . .|. | |   .   ||||| |.   |    |.| ||...|      .| .|  || | |||||.|....   |||.|   |    .|. |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

aKGTPERYNELEVTLELkEKFASYTLRT--FLLKHRHKKHGKVPERRVYHFHyTDWPDHGVPPYTLPVLSFIQRSSAanptdagPIIVHCSAGVGRTGTY
 |   .    .  .|.. | .  .      | . . .   |.  || . |.   |.   .   . | ||  ... |        |..|..  || ...| 
.kaesdslvtvpGslri.enlkvdskadplfrvtklklvGgddeerflehwq.gdvnnssdvysplrvlrklrnlsk.......pvvvqdilGvskaatl

IVIDTMLKQMQ--AEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKstELRQYVDRM
. |.. | ..      |  |    . .| .|.. |..  .|.|.. ..| ..|     .|  ||    .| 
vaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsak..eldvdyerw
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 668-932 4.8e-76 250.9 In-house 17-273 (284) alignment 
Range on Protein: 668-932
Range on HMM: 17-273/284.0
ATFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITkleergRRKCDRYWPA
 ||.   .|| |||...|...| ..| |..| |.  |||||| .| |. |.. |||||| |. | .||||..||...  ||..|      . || .||| 
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

KGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKHGKvpeRRVYHFHYTDWPDHGVPPYTLPVLSFIQRSS--AANPTDAGPIIVHCSAGVGRTGTYI
|.  ..... .| ... |. . |..| . | .  |....   |..  ||.  |||.||| |. ... .... .       .  .|.|||||||||||.||
kiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdi...rkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

VIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKSTELRQYVDR
|.|..|..|. |..|.|. |.. .| ||| |||   || ||.  |||    |.. |   ..  |...
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpaylee
0040439 (Phosphotyrosine protein) phosphatases II 669-914 4.6e-84 277.2 In-house 4-246 (249) alignment 
Range on Protein: 669-914
Range on HMM: 4-246/249.0
TFSSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAk
.... .||| ||||..|. ||.||| |..||| . ||||||.||||.......||||| |. |..||||..||... ||||.|.|.|.|| ||..|||  
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

GTPERYNELEVTLELKEKFASYTLRTFLLKHRhkkhGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPT--DAGPIIVHCSAGVGRTGTYIV
|..  |... |||   |....||.||. |..     .. ..|.|.|..|||||||||||.. ..|.||..   |. .  . ||..||||||||||||.|.
ggsleygdftvtllsvevkddytvrtleltnl....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

IDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
...|| |.. | .|...  .| .|.||.. ||..|||.|....|||.|
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 670-777 3.2e-25 83.6 In-house 41-162 (350) alignment 
Range on Protein: 670-777
Range on HMM: 41-162/350.0
FSSDVENKLKNRYTNIVSYDSSRVSLQ----PLP----GIPNSDYINANYIDGF------NRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEE
.|. ||   ||||.||. |. ||| |.    .       .  .|||||||.         | .  |||||. |. |.|||.... . |  ||...|.. |
lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdve

RGRRKCDRYWPAKGTPERYNEL
 ...||.|||.  .  .    |
lnlekcyrYWqegsydditvkl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 670-780 6.1e-16 52.7 In-house 42-164 (349) alignment 
Range on Protein: 670-780
Range on HMM: 42-164/349.0
FSSDVENKLKNRYTNIVSYDSSRVSL----QPLPGIPNS----------DYINANYID--GFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKL
.|. ||   |||| .|. |. ||| |    ..  .| .|          |||||||.    .. .| |||||  | .| |||....  ..  ... ... 
lseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLndd

EERGRRKCDRYWPAKgtpeRYNELEVT
.| . .|||.||        |.. .| 
kelslekcdiywqel....sysnitvk
0042113 (Phosphotyrosine protein) phosphatases II 671-914 7e-81 266.5 In-house 4-243 (245) alignment 
Range on Protein: 671-914
Range on HMM: 4-243/245.0
SSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAkGT
.. .||| ||||..|. ||..|| |.| .| . ||||||.|.||... . .||||| |. |..||||..||... .|||.|..||.|| ||..|||  |.
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

PERYNELEVTLELKEKFASYTLRTFLLKHrhkkHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANP-TDAGPIIVHCSAGVGRTGTYIVIDT
. .|... |||   |....||.||. ...    .|. ..| |.|.||..|||||||...  .|.|...   |   .. ||..||||||||||||.|....
sltygdftvtllseehlddytvrtlevtn....lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

MLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
|| |...| .|...  .|..| ||   |||..||.|....|||.|
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 671-913 1.4e-72 239.4 In-house 5-241 (243) alignment 
Range on Protein: 671-913
Range on HMM: 5-241/243.0
SSDVENKLKNRYTNIVSYDSSRVSLqplpgiPNSDYINANYIDGFNRqkaYIATQGALKTTFDD----FWRLVWEQKSVVIVMITKLEERGRRKCDRYWP
.. .||. ||||..|. || ||| |      ..|||||||.|....|   .||||| |. |..|    |||..||... ||||.|.|.|.|| ||..|||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

akGTPeRYNELEVTLELKEKFASYTLRTFLLKHrhkKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAA--------NPTDAGPIIVHCSAGV
  |.  .|....|||   | ...||.||.||..   .  . ..| |.|.||. |||||||. . ..|.|..   .         .  . ||..|||||||
..gev.tygdftvtllseehlddytvrtlllen...ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTYIVIDTMLKQMqaeeKVNVFGFLKRIRTQRNY-LVQTEEQYVFIHDVLLEW
|||||.|....||...    .|...  .|..|.||..  |||..||.|....|||.
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRN_pd Subfamily PTPRN 671-910 4.8e-55 181.4 In-house 51-288 (297) alignment 
Range on Protein: 671-910
Range on HMM: 51-288/297.0
SSDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYI-DGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKG
... .|  |||......|| |||.|.      .||||||  | |   |. ||||||| | .|  |||..|||| .||||..|.||| | ..|.|||| .|
akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG

TpERYNELEVTLELKEKFA-SYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVID
. | |.  || |  .  ..  | .|.| ||  ....     | |  ||.  ||..|||. . ..| | ..   .    . ||.||||.|.||||.||.||
s.evyhiyevhlvsehiwcddylvrsfylknlqtse....trtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

TMLKQMQA-EEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVL
 .|....    ....   |. .| ||. ||.|..|. |.  ..
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 671-915 2.4e-36 120.2 In-house 38-272 (288) alignment 
Range on Protein: 671-915
Range on HMM: 38-272/288.0
SSDVENKLKNRYTNIVSYDSSRVSLQplpgiP-NSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPA-K
.| ..|  ..||.|.   | .|| |.          ||.|| .   . ..  | .|  |..| . .|... |.    |||...| |.|..| . |.|  .
dsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

GTPERYNELevTLELKEKFAS--YTLRTFLLKHRHKKHGKVperRVYHFHYTDWPDHGVPPYTLPVLSFIQRSsaanPTDAGPIIVHCSAGVGRTGTYIV
|   |.. |      |.| |    ...  ||.  .. . ||    | . |. .|.|.|||   |. | ....      .   ||.||.||||||||| |.
Gekarigrl..ctvvkkkradidklvkvsllriskegeekv...ivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlil

IDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
|  .|.... .. . .  .|.. | .|   .||| ||...| ..|| | 
ilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 671-924 1.2e-31 104.8 In-house 30-279 (285) alignment 
Range on Protein: 671-924
Range on HMM: 30-279/285.0
SSDVENKLKNRYTNIVSYDSSRVSLQPlpgiPNSDYINANYIDGF-NRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAK-
..   |   |||...   . .|| |.      . ||| |...    . | .||.||| |  |. |||......|   ..|.  | | |  ||  |.| | 
tayeanpdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypekl

GTPERYNELEVTL-ELKEKFASYTLRTFLLKHRHKKHGKVPeRRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAgPIIVHCSAGVGRTGTYIVI
|   .. . |.|| | ||.  . |.   |     .     |   . | .   |||.  |  . |.. . .     || .  || |||||||||| |.. |
gevvkfgkyeitlteckeeaiagtilnaltvintedassep.lymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgi

DTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLrAGNTVVKST
|    ..  . .....  .. .|. |   ||.  |..|.. ||.|..  |. ||. |
dyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf.igegvvert
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 672-915 2.7e-65 215.0 In-house 16-265 (270) alignment 
Range on Protein: 672-915
Range on HMM: 16-265/270.0
SDVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFN-RQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGT
. . .|  |||..|.    .|| |..|   ... ||||||. ||. ..|.|||..| |.||  .|||..||.|.  |||.|.|||.||.||.|||||.  
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

P---ERYNELEVTLELKEKFASYTLRTFLLKhrhkKHGKvpERRVYHFHYTDWPDHGVPPYTL------PVLSFIQRS--SAANPTDAGPIIVHCSAGVG
     .. ...|. . .||   | |.   |.    ..|.  |||. ||.|..|||||||. .        .|. ..    |  .  .|.|..||||||||
ekvkledgkikvlalseekeegyiltrlrle....ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
|||| |..|.... .. ..||.|   ....| .|  |||. ||| |.. ...|. .
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 673-916 2.2e-83 274.3 In-house 6-244 (250) alignment 
Range on Protein: 673-916
Range on HMM: 6-244/250.0
DVENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRkCDRYWPAKGtPE
. .|| ||||..|...||||| |..  |  .|||||| ...|.. .||.||||| |..|. ||||.|.|.|| .|||.|.|.| ..  . .|||... .|
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.ae

RYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPT-DAGPIIVHCSAGVGRTGTYIVIDTML
.| .. |.|  ||.|| || |.. | ...|..    || | ..|.. ||| ||| ..  || ....  | ..  ...|.||.|||||||.|..|.||..|
kyGdvtvsllskeefadytkrklklskakkad....erivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

KQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRA
.... |..|.|| ..|..|..|   |...|||||.. ..|. | .
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 673-917 2.7e-45 149.4 In-house 45-290 (305) alignment 
Range on Protein: 673-917
Range on HMM: 45-290/305.0
DVENKLKNRYTNIVSYDSSRVSLQPlpGIPnSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPE
. ... |||| ..   |  || |..    |  .|| |||.      | .| ||  |. |  ||| . ...|   | |. .| |.| .||  |...|  ..
eaqeagknrykdvgcldnnrvkleg..pwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

-RYNELEVTLELKekFASYTLRTFLL-------KHRHKKHG-KVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAAnptdAGPIIVHCSAGVGRTGT
  ..| .  . .|  | | .   |         .      |     |.| |.|. |||| |||.  | .| ..... ..     |||.||||||.||||.
lefeekgqkisvk..fessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps....kgpivvhcsagigrtgs

YIVIDTMLKQMQAEEKVNV-FGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
 .... .|.|. | ....     |..|| |||  .||..||.|.|.|.|...|  
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
subfamily_eak_pd Subfamily eak 673-828 8.8e-14 45.6 In-house 49-197 (332) alignment 
Range on Protein: 673-828
Range on HMM: 49-197/332.0
DVENKLKNrYTNIVSYDSSRVSLQPLPGiPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKG-TP
 .|.  .|   .|| ||   | | .     .  ||||  ..  .  . || |  | ..    ||..| ||||  ||.. .  | .  | |.|.| |.   
rleavnrn.vvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

ERYNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvperRVYHFHYTDWPDHGVPPY
 ..  |.|.     | . .  | . |.   . |      ||.|...  | .  .| |
lkfGildverkefvkrniletrllelskGneth......rvlhykvfGwtettlpky
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 673-787 1.1e-12 42.1 In-house 93-201 (244) alignment 
Range on Protein: 673-787
Range on HMM: 93-201/244.0
DVENKLKNRYTNIVSYDSSRVSLQPlpGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERgrrkcDRYWPAKGTPE
. .|  |||    . .| .|| |    |     |||| ..  . |   || ||  |  |  |||... |..  |.|..  .||      | |||     |
npnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseple

RYNE-LEVTLELKEKF
 |.| . |||  ...|
wyeeditvtltdrdef
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 673-751 6.4e-08 26.5 In-house 34-117 (347) alignment 
Range on Protein: 673-751
Range on HMM: 34-117/347.0
DVENKLKNRYTNIVSYDSSRVSLQPL-----PGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMIT
   .  |||  .    |..|| | |      .  .   |||| .|   | .| || ||  |  |  |||..|   |   .| | 
wekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_CG7180_pd Subfamily CG7180 674-914 1.9e-64 212.2 In-house 40-290 (296) alignment 
Range on Protein: 674-914
Range on HMM: 40-290/296.0
VENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRrKCDRYWPAKGtPER
 ||. |||. ..| ||  || |. | |  .|||||| |.|.| ..|.|| |..  | | |.|||||.....  .|..||  .  . ..  ||| |.  |.
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keq

YNELEVTLELKEKFASYTLRTFLLKHR------HKKHGKVPERRVYHFHYTDWPD-HGVPPYTLPVLSFIQRSSAA-----NPTDAGPIIVHCSAGVGRT
| |..| .  ....|  . ||| |...      ..|. |...| | .|..| |.  . ||  |  .. ...|         .  . ||..|..| |..|.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
| |. ||  | ... ||.|.||...|..| .|. ||.. |.| .| |||||..
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 675-912 1.7e-72 238.5 In-house 2-237 (237) alignment 
Range on Protein: 675-912
Range on HMM: 2-237/237.0
ENKLKNRYTNIVSYDSSRVSLQPLPGipNSDYINANYIDGFNR-QKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPER
|||.|||| |||.|| ||| |.   .  .||||||.|..||.   | |||.|| |... ||||..||..|  ||||.| | |. . || .|||    |. 
enkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YNELEVTLELKEKFASYTLRTFLLKHRHKKHgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPT--DAGPIIVHCSAGVGRTGTYIVIDTML
|  | |.|  ||.|. ||.|..|| .|....     | .. ...| |||.||| .|  .| | ..    .|   ..|| |.|||||||||| ..|||.||
ygvltvslkkkeefsdytvrslllskrltlk...evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

KQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLE
.| . .. |... ... |  .| |..||..||||||...||
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_ptpA1_pd Subfamily ptpA1 675-875 2.2e-39 130.4 In-house 46-257 (418) alignment 
Range on Protein: 675-875
Range on HMM: 46-257/418.0
ENKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFNrQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERY
 |  |||||||.  . .|| |. .     |||||||||||    | .|.||| |  |  ||||.|||..  .|||...  |  | ||||||| .   |..
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

NELEV--------TLELKEKFASYTLRTFLLKHRHKKHGKvpERRVYHFHYTDWPDHGVPPYTLPVL----SFIQRSSAANPTD--AGPIIVHCSAGVGR
.            ..|| |            . |    |.   | . ...|  |||| .| .| |.     |  .|     |.     ||||||||||||
siygngnevfgtysvelveviqdpereiitrnirltfege..trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGTYIVIDTMLKQMQ
|||.     |.|...
tgtfctavimmkkld
Y_phosphatase Protein-tyrosine phosphatase 676-912 5.3e-85 279.9 Pfam-A 1-235 (235) alignment 
Range on Protein: 676-912
Range on HMM: 1-235/235.0
NKLKNRYTNIVSYDSSRVSLqplPGIPN-SDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWP-AKGTPER
|| ||||..|. ||..|| |    | .. ||||||||..|....|..||||| || |..||||.||..|. ||||.|.|||.||.||..||| .......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YNELEVTLELKE--KFASYTLRTFLLKHRHKKHgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTML
|....|.|. ||  . ..||||.. ||.. ...    .|.|...|||.|||||||  . ..|..|..    . .. ||..||||||||||||....|..|
ygdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

KQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLE
.|..|||.|.|. ..|..|.||. .||..|||.|.....||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 676-912 5.3e-85 279.9 In-house 1-235 (235) alignment 
Range on Protein: 676-912
Range on HMM: 1-235/235.0
NKLKNRYTNIVSYDSSRVSLqplPGIPN-SDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWP-AKGTPER
|| ||||..|. ||..|| |    | .. ||||||||..|....|..||||| || |..||||.||..|. ||||.|.|||.||.||..||| .......
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YNELEVTLELKE--KFASYTLRTFLLKHRHKKHgkvPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTML
|....|.|. ||  . ..||||.. ||.. ...    .|.|...|||.|||||||  . ..|..|..    . .. ||..||||||||||||....|..|
ygdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

KQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLE
.|..|||.|.|. ..|..|.||. .||..|||.|.....||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 676-912 1.1e-71 235.8 In-house 7-238 (239) alignment 
Range on Protein: 676-912
Range on HMM: 7-238/239.0
NKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFN-RQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGtpERY
|| ||||.|||.|| ||| |. |   | ||||||.|.  ..   ||||||||.....  ||||..|... .||||.| | |  ..|| .|||      .|
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sky

NELEVTLELKEKFASYTLRTFLLKhrhkKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQM
 .| |||   | || | .|||..     . |.  || ||..|.| |||.||| |.  || . .. .  .   | | ..||||||||||...|||.||.| 
cnlrvtlrktevfadyiirtfvms....qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

QAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLE
. .. |..| ..| || .| ..||| |||||||  .||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 676-912 1.3e-71 235.5 In-house 8-239 (239) alignment 
Range on Protein: 676-912
Range on HMM: 8-239/239.0
NKLKNRYTNIVSYDSSRVSLQPLPGIPNSDYINANYIDGFN-RQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGtpERY
|| ||||.|||.|| ||| |. |   | ||||||.|.  ..   ||||||||.....  ||||..|... .||||.| | |  ..|| .|||      .|
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sky

NELEVTLELKEKFASYTLRTFLLKhrhkKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQM
 .| |||   | || | .|||..     . |.  || ||..|.| |||.||| |.  || . .. .  .   | | ..||||||||||...|||.||.| 
cnlrvtlrktevfadyiirtfvms....qvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

QAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLE
. .. |..| ..| || .| ..||| |||||||  .||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
0041856 (Phosphotyrosine protein) phosphatases II 676-921 2.3e-52 172.6 In-house 1-178 (182) alignment 
Range on Protein: 676-921
Range on HMM: 1-178/182.0
NKLKNRYTNIVSYDSSRvslqplpgipNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITkleergrrkCDRYWPakgtperyn
|. ||||..|. || ||          ..||||||...|  ... .||||| |. |. ||.|...|..  .||..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

elevtlelkekfasytlrtfllkhrhkkhgKVPERRVYHFHYTDWPDHGVPPyTLPVLSFIQRSSAanptDAGPIIVHCSAGVGRTGTYIVIDTMLKQmq
                              .  || .....|. |||||||. .  .|.||..  .    . ||..||||||||||||..... |.|.  
..............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl..

aeeKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVV
   .|...  .| .| .|.  |.|..||.|....|||.|. ..|..
...gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 676-917 2.4e-29 97.1 In-house 43-279 (312) alignment 
Range on Protein: 676-917
Range on HMM: 43-279/312.0
NKLKNRYTNIVSYDSSRVSLQplpGIPNsDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGT-----
 |  ||| ||  .|  | .|    |  |  || ||..    . . ...|||.|. |   ||.|.    |. |.... . | |  || .|     .     
fkdlnrypniqcwdrgrftla...gden.fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

-PERYNELEVTLELKEKFASyTLRTFLLKHRHKKHGKvpERRVYHFHYTDWPDHGVPPYTlpvlSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDT
    | |    .|.  |     .   .||   |  |.  | .. |. .. |||||.|          .|  .|   |  |.| ||||||||||| ..|..
dhrvyteycteieiggkskd.kithrvlkvvvkatgq..esklnhyqwaswpdhgmpdsc....dtalrllsavkkdkkpviahcsagvgrtgtlalies

MLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
|.  ..   | ||   .  .| .|   |..  |||.   ..||.| . 
miaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 677-922 1.9e-19 64.9 In-house 20-268 (290) alignment 
Range on Protein: 677-922
Range on HMM: 20-268/290.0
KLKNRYTNIVsYDSSRVSLQPLPGIPNSDYINANYIDgFNRQKAYIATQGA-------LKTTFDDFWRLVWEQKSVVIVMITKLEERGRR----KCDRYW
....|... .    .|| |.      |.||| ||..  .    . |.||          . |  .|| .. . |.  .||. . ||. .      | .| 
emdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PAK-GTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKhgkvpERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSaanpTDAGPIIVHCSAGVGRTGTY
| . |.  ... |.|    |||      |. ..|.  ..     |  | |  . .| .  |.. |. .|| ||       .   |.||||  |. |  . 
pesvgeelkfkgltvkCkskekeddvetRelvvkfddee.....eftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAal

IVIDTMLKQMQ-AEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVL-LEWLRAGNTVVK
  |.     .   ...|..   || .| ||. ........ |.  .. |   ........
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfae
0044763 (Phosphotyrosine protein) phosphatases II 688-917 1.4e-38 127.6 In-house 2-174 (178) alignment 
Range on Protein: 688-917
Range on HMM: 2-174/178.0
YDSSRVSLQPLPGIPNSDYINANYIDGFnrqkAYIATQGAlkttfDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTperynelevtlelkekf
.| .||.|..|.|.. ||||||..|...     |......      |...|..|..  .||..|.  |.|. |||.||| .                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

asytlrtfllkhrhkkhgkvperrvYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQmqaeeKVNVFGFLK
                         ...... .||||||. .  .| |..   .| ... ||..|||||||||.|| .... |.|.     .....  ..
.........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

RIRTQRNyLVQTEEQYVFIHDVLLEWLRAG
..| .|.  |....|. ..... |..|  .
lvrerRp.ivpnpgqlrqLyefelrllkes
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 688-825 9e-10 33.0 In-house 5-126 (130) alignment 
Range on Protein: 688-825
Range on HMM: 5-126/130.0
YDSSRVSlqplpgipNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERgrrkcDRYWPAKGtPERYNELEVTLELKEKF
.. ||.         . .||||...   .| . |. || .|  |  |||... |.   |.|..  .||      | |||    |  . | .... | .. 
fevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdse.Plewyeediivtltdrd

ASYTLRTFLLKHRHKKHgkVPERRVYHFHYTDWPDHGV
 .  ...  |.  ..       . .  |. ..||  | 
efknikasnleiesdln..eshqaltmfqisnwpsdgt
0046846 (Phosphotyrosine protein) phosphatases II 696-914 3.8e-42 139.3 In-house 4-173 (176) alignment 
Range on Protein: 696-914
Range on HMM: 4-173/176.0
QPLPGIPNSDYINANYIDGFnrqkAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTPERynelevtlelkekfasytlrtf
..|   ...||||||.|.|     ..||||| |  |. ||.....|..  ..|..|.. | || ||..|||   ...                       
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

llkhrhkkhgkvperrvyHFHYTDWPDHGVPPYtLPVLSFIQRSSAANPTDaGPIIVHCSAGVGRTGTYIVIDtmlkQMQAEEKVNVFGFLKRIRTQRN-
                  ......|||||||..   .|....    |   . ||..||||||.|||||.....     .. |  ..|.  |...| ||  
..................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRpl

YLVQTEEQYVFIHDVLLEWL
. |||.||| |.....|..|
gavqtpeQyrflyefellll
0051429 (Phosphotyrosine protein) phosphatases II 701-916 5.2e-55 182.2 In-house 1-227 (272) alignment 
Range on Protein: 701-916
Range on HMM: 1-227/272.0
IPNSDYINANYIDGFNR---QKAYIATQGALKTTFDDFWRLvWEQKSVVIVMITKLEERGRRKCDRYWP-----------AKGTPERYNELEVTLELKEK
.| |.||||....|..|    .......| |. | .||||| .|..  .||.....||||| |||||||              .. .|. | |||  .| 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

FASYTLRTFLLKHRHKKHGKvpeRRVYHFHYTDWPDHGVPPYTlpVLSFIQRSSAanptdAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVN-----
.  |.||..||.. .. .     |.|.|.|||||||||||. .  .|....   .      ||..||||||..||||..... .| .. .|  |.     
lldyilrellltlllsagea...revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRA
   ........| || . |||||||.|....|||.||.
nlyleeaveelraqrpgavqteeqylflyeallellrs
0043147 (Phosphotyrosine protein) phosphatases II 702-907 1.8e-42 140.3 In-house 3-154 (172) alignment 
Range on Protein: 702-907
Range on HMM: 3-154/172.0
PNSDYINANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLeergrrkcdrywpakgtperynelevtlelkekfasytlrtfllkhrh
..||||||.|.|.    . .||||| |  |..||||...|..  .||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

KKHGKVPERRVYHFHYTDWPDHGVPpYTLPVLSFIQRSSA-ANPTDAGPIIVHCSAGVGRTGTYIVIDTMLkqmqaeEKVNVFGFLKRIRTQRNYLVQTE
 . ..  || .....|. |||||||  .  .|.|..     ..  . ||..|||||||||||| .... ||      ......  .. .|..|.. ||..
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

EQYVFIH
.|| |..
sqyrfly
0051082 (Phosphotyrosine protein) phosphatases II 703-911 7e-36 118.4 In-house 2-150 (151) alignment 
Range on Protein: 703-911
Range on HMM: 2-150/151.0
NSDYINANYIDGFnrqkaYIATQGALKttfdDFWRLVWEQKSVVIVMITKLEERGrrKCDRYWPAKGtperynelevtlelkekfasytlrtfllkhrhk
 |||||..|..|.     .....| |     ||..|..|..  .||.....||||  .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

khgkvpeRRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAanpTDAGPIIVHCSAGVGRTGTYIVIDTMLkQMqaeekVNVFGFLKRIRTQRNYLVQTEEQ
       ..|.|....||||.|.| ..  ||.|..   .   .. ||..||||||.||||| .... || ..     |...  |. .| .| ..||...|
.......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqq

YVFIHDVLL
..|.. .||
flfqlfall
0036282 (Phosphotyrosine protein) phosphatases II 704-908 1.5e-47 156.8 In-house 2-164 (174) alignment 
Range on Protein: 704-908
Range on HMM: 2-164/174.0
SDYINANYIDGFNRQKAYIATQGALKttfddFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAkgtperynelevtlelkekfasytlrtfllkhrhkk
||||||...|.. . . .||.|| |.     ||....|... ..|| ....|.|. || .|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

HGKVPERRVYHFHYTDWPDHGVPPYTLpVLSFIQRSSAANPT-DAGPIIVHCSAGVGRTGTYIVIDTMLKQMQaEEKVNVFGFLKRIRTQRNYLVQTEEQ
. . .|| .....|. |||||||. .  .|.|...   |    . ||..|||||||||||| .... ||...  |  |... .....|.|| . |||..|
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YVFIHD
| |...
yrflyy
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 707-905 4.6e-29 96.1 In-house 78-272 (301) alignment 
Range on Protein: 707-905
Range on HMM: 78-272/301.0
INANYIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTperyNELEVT-LELKEKFASYTLRTFLLKHR---HK
| ||.|.   . . .||||| || | .||| ..   .   |||...  |.  .||. | | | .    ..|..   ..| |   . |.  . | .   . 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis....ekldigrfkikiknkelilnkkiskrtleved

KHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANptdaGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQ
  ||.. | | |. |..|.|.|||     .  ...    ..     ||.||||||.||. ..|  . . ....|. ....   ||..| .|   |||..|
stgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq

YVF
  .
lyw
0049260 (Phosphotyrosine protein) phosphatases II 711-908 2e-42 139.8 In-house 1-144 (152) alignment 
Range on Protein: 711-908
Range on HMM: 1-144/152.0
YIDGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWpakgtperynelevtlelkekfasytlrtfllkhrhkkhgkvper
.|||.......||||| .  |..||||...|..  .|||.|.|.|.|. ||..|.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

rvyHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLkqmqaeEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHD
   ..... |||||||. .  .| ...    ..  . ||..||||||||||||..... ||       .|... .....|..|.. |....|. |...
...qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 713-804 3.2e-10 33.9 In-house 230-318 (440) alignment 
Range on Protein: 713-804
Range on HMM: 230-318/440.0
DGFNRQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERgrrKCDRYWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKHRHKKH
.|. ...|.||||  | .|  |||||| . .   |.|. .|...    |  ||| .     .  . |     |..    .||. ||.. . |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevh
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 717-908 5.7e-22 72.9 In-house 3-198 (199) alignment 
Range on Protein: 717-908
Range on HMM: 3-198/199.0
RQKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKG-TPERYNELEVTLELKEKFASYTLRTFLLKHRHKkhGKVPERRVYHF
 |. ||||| .|. |. |||..|||  |  |||.   .         |||.   .  .|  | || .     . ||. ...|            | . |.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt..appstreishy

HYTDWPDHGVPPYTLPVlSFIQR----SSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAE--EKVNVFGFLKRIRTQRNYLVQTEEQYVFIHD
 .| | ..  |  .| |  |.      |   .     |.||||| | | || .. .|  ..  .      |..|   ||.|  |  .. . ..| ||..
qftswkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 718-908 6.8e-22 72.6 In-house 3-197 (198) alignment 
Range on Protein: 718-908
Range on HMM: 3-197/198.0
QKAYIATQGALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKG-TPERYNELEVTLELKEKFASYTLRTFLLKHRHKkhGKVPERRVYHFH
|. ||||| .|. |. |||..|||  |  |||.   .         |||.   .  .|  | || .     . ||. ...|            | . |. 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt..appstreishyq

YTDWPDHGVPPYTLPVlSFIQR----SSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAE--EKVNVFGFLKRIRTQRNYLVQTEEQYVFIHD
.| | ..  |  .| |  |.      |   .     |.||||| | | || .. .|  ..  .      |..|   ||.|  |  .. . ..| ||..
ftswkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 723-914 1.5e-19 65.1 In-house 39-221 (255) alignment 
Range on Protein: 723-914
Range on HMM: 39-221/255.0
AtqgalktTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTpERYNELEVTLELKEKFASYTLRTFLLKHRHKKhgKVPERRVYHFHYTDWPD
        | | |.. .  .|. |.||.. ..| |. ||..|.| .   |.    .|..   .  |   |||  .     .  |   . | |..|. |..
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekd.eklkladvnvtttkssadvvlrtleitstlge..kkkthtvkhysykGWie

HGVPPYTLPVLSFIQRSsaanpTDAGPIIVHCSAGVGRTGTYIVID----TMLKQMQAEEKVNV--FGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
.  |  .  .|  ..       .|. ...||||.|.||. ......    .|.....  | |..    .|. .| .|.  ..|  |  |   ..|...
knaPelareilnilkvv.....rdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_hpo-7_pd Subfamily hpo-7 723-913 1.3e-14 48.8 In-house 42-226 (263) alignment 
Range on Protein: 723-913
Range on HMM: 42-226/263.0
AtqgaLKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAK-GTPERYNELEVTLelKEKFASYTLRTFLLKHRHKKhgKVPERRVYHFHYTDWP
     |  | | |.. .  .|. |.||..  .| |. ||..|.| .     ......|.    .      |.|  |    ..  |   . | |. |. |.
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvct..tkvqsdvllktlellstlge..KkkthtvkhysykgWi

DHGVPPYTLPVLSFIQRSsaanpTDAGPIIVHCSAGVGRTGTYIVID----TMLKQMQAEEKVNV--FGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
..  |  .  .|  ..       ..  ...||||.|.||.  . |..    .|.....  . |..    .|. .| .|.  ..|  |  |   ..|..
ekndpelareilnilkva.....rnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 726-906 1e-19 65.2 In-house 98-280 (302) alignment 
Range on Protein: 726-906
Range on HMM: 98-280/302.0
GALKTTFDDFWRLVWEQKSVVIVMITKLEERGRRKCDRYWPAKGTP-ERYNELEV-TLELKEKFASYTL----RTFLLKHRHKKHGKVPERRVYHFHYTD
   | | . .| |. . .  ..| .... | . .||  |.  |     ....  | |...|.... .|     . . .. . .|. |  .. |  .... 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPPYTLPVLSFIQRSSAANpTDagpIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFI
||||| |  . . |  ..   .   ..   ..|||||||||||| . |   ..  . ..  ..   .. .|. |   ||.|.| ...
wpdhGapkeaytaldilkfcesyk.kn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 760-913 8.4e-08 26.1 In-house 149-301 (332) alignment 
Range on Protein: 760-913
Range on HMM: 149-301/332.0
KCDRYWPAKGTPERYNELEVtlELKEKFASYTLRTFLLKHRHKKHgkvpERRVYHFHYTDWPDHG-VPPYTLPVLSFIQ----RSSAANPTDAGPIIVHC
 | ..|| |.. . .  | .  .  . ..   ..|| |    ||.    ...   .|. .| |   .| | | . . |.    |||       |||.. |
icrkfwpekrskkdfpalsi..qasddhsethmktfnltvtekkq....dhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvc

SAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
..|| .   .  || .. ..  | .| .   .  |. ||   ..|   |    ..|...
atgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkf
0048076 (Phosphotyrosine protein) phosphatases II 764-913 2e-27 91.0 In-house 2-142 (145) alignment 
Range on Protein: 764-913
Range on HMM: 2-142/145.0
YWPAKGTPERYNELEVTLELKEKFASYTLRTFLLKhrhKKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDaGPIIVHCSAGVGRTGT
|||.. .|  |     | .  | .... ..| |         . .|| .....|..|||||||. .  .|.|..   .| . . ||..||||||||||||
ywpseilpglylgslptaldlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgt

YIVIDTMLKqmqaeEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
..... ||.     ..|...  |...|.|| . |....|. |.....||.
lvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefelel
0038934 (Phosphotyrosine protein) phosphatases II 796-891 7.1e-10 34.3 In-house 49-160 (194) alignment 
Range on Protein: 796-891
Range on HMM: 49-160/194.0
LLKHRHKKHGKVPER--------------RVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTD-AGPIIVHCSAGVGRTGTYIVIDTML-KQMQAEEK
.||....|.|.|                 . ....   .||.|..| .  .|.|..     .  |  | . ||| ||.||||| ..   .   .| ||| 
ylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeA

VNVFGFLKRIRT
.. | . ..   
ialfrekRpgai
0048179 (Phosphotyrosine protein) phosphatases II 798-908 1.1e-25 85.4 In-house 35-139 (144) alignment 
Range on Protein: 798-908
Range on HMM: 35-139/144.0
KHRHKKHGKVPERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDaGPIIVHCSAGVGRTGTYIVIDTMLkqmqaEEKVNVFGFLKRIRTQRNYLV
  ... .   .|| ........|||||||...  .|.|..   .| . . ||..||||||||||||..... |.     .......  |...|..| . |
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgav

QTEEQYVFIHD
....|. |...
pnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 809-938 4.3e-28 92.8 In-house 88-218 (440) alignment 
Range on Protein: 809-938
Range on HMM: 88-218/440.0
ERRVYHFHYTDWPDHGVPPYTLPVLSFIQRSSA-ANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIH
 | . ..||  |||.||| .. ||| .||  .   . .  ||..||||||.||||  |..|..|.. .  .....| |.. .| .|  .||| |||.|.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DVLLEWLRAGNTVVKSTELRQYVDRMTLPDE
...|| | .|.|..   .. . |...  |. 
eavlegllcgdtliledditerveqiqwpnp
subfamily_PTPDC1_pd Subfamily PTPDC1 809-908 9.1e-08 26.7 In-house 80-170 (182) alignment 
Range on Protein: 809-908
Range on HMM: 80-170/182.0
ERRVYHFHYtDWPDHGVPPYTLpVLSFIQRSSAAnpTDAGPIIVHCSAGVGRTGTYIVIDTMLK-QMQAEEKVnvfgflKRIRTQRNYLVQTEEQYVFIH
|. .|.. .  |.|.||.. .  .|  ..  . |   . | . ||| || ||||  |    . . ...||. .      | .| .|   .|| ||  ...
eqgiyvynf.gwkDygvasler.iLdivkvvafa..lqegkvavhChaGlGrtGvliacylvyakrltaekai......klvrskrpksiqtreqvelvk

D
.
e
subfamily_PTEN_pd Subfamily PTEN 809-906 3e-07 25.6 In-house 79-172 (184) alignment 
Range on Protein: 809-906
Range on HMM: 79-172/184.0
ERRVYHFHYTdwpDHGVPPYTLpVLSFIQRSSAANPTD-AGPIIVHCSAGVGRTGTYIVIdTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFI
. || ..  .   ||  ||  | . ....  ..   .|    ..||| || ||||. ||   .||... |.. ..  . ...||. .  |.   |  ..
dgrvavypfd...Dhnppplel.leeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYv
PTPc_DSPc_SM00012 812-912 3.3e-36 119.0 In-house 2-105 (105) alignment 
Range on Protein: 812-912
Range on HMM: 2-105/105.0
VYHFHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDA--GPIIVHCSAGVGRTGTYIVIDTMLKQMQAE-EKVNVFGFLKRIRTQRNYLVQTEEQYVFIHD
|.|.|||.||||||| .. ..|....     .   .  .|..||||||||||||....|..|.|...| ..|..| ..|..|.||. .|||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VLLE
.|||
alle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 812-913 5e-14 46.8 In-house 217-343 (350) alignment 
Range on Protein: 812-913
Range on HMM: 217-343/350.0
VYHFHYTDWPDHG---VPPYTLPVLS----FIQRSSAANP---TDAGPIIVHCSAGVGRTGTYIVIDTMLK-----QMQA----------EEKVNVFGFL
||....  |.| .    |   |..|     .|.   | .      . ||.||||||||||||.. .| .|.     ..            . .  ..  .
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KRIRTQRNYLVQTEEQYVFIHDVLLEW
...| ||  .||. .|..||.. || .
nelrkqrismvqnldqfifiYeallfy
PTEN_1 813-863 6.2e-06 21.1 In-house 95-146 (196) alignment 
Range on Protein: 813-863
Range on HMM: 95-146/196.0
YHFHYTDWPDHGVPPYTLP---VLSFIQRSSAANPtdAGPIIVHCSAGVGRTGT
. ..  ...|||.|.       . |||.  .....   . ..||| ||.||.||
veylhfpieDhgapslselfdicksfiewllsdpn..gnvVlVHCkaGlgRsGt
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 815-915 5.5e-07 22.5 In-house 210-310 (346) alignment 
Range on Protein: 815-915
Range on HMM: 210-310/346.0
FHYTDWPDHGVPPYTLPVLSFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
 |.. |     || |||.. .| .  . .   .  . |    | ||. ..|     ..|..   . |..  .| |. ||   |..  ||  |. ......
hhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

R
 
a
PTPc_motif_SM00404 824-890 5.8e-06 21.3 In-house 61-121 (140) alignment 
Range on Protein: 824-890
Range on HMM: 61-121/140.0
GVPPYTLPVLSFIQRSsaanPTDAGPIIVHCSAGVGRTGTYIVIDTML-KQMQAEEKVNVFgflKRIR
 . .|   ||.||...     .. | ..||| ||| |..| |.   |  .|....| ....   |. |
klskyldkvldfiena....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefv...kerR
subfamily_eak_pd Subfamily eak 834-923 5e-10 33.3 In-house 225-314 (332) alignment 
Range on Protein: 834-923
Range on HMM: 225-314/332.0
SFIQRSSAANPTDAgPIIvHCSAGVGRTGTYIVIDTMLKQMQAeEKVN---VFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAGNTVVKS
|....   . |. | |||  .. |  |.|...||| ... ...  | |   |  .. .....|.. | .. |. ||....|..|.  |  .. 
stlkkyihtppsfa.pii.qsarGsaraGvfvvidllirlidn.kkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrd
subfamily_CDC14_pd Subfamily CDC14 834-895 2.3e-06 21.7 In-house 250-315 (328) alignment 
Range on Protein: 834-895
Range on HMM: 250-315/328.0
SFIQRSSAANPTDAGPIIVHCSAGVGRTGTYIVIDtMLKQMQAEEkVNVFGFLKRIRT------QRNY
. ...  ..  .  | |.||| ||.||||| |    ..|. .     .. ..|. .|       |...
aivkkfleiaekaeGaiavhCkaGLGrtGtLiacy.lmkhyrfta.aeaiawlricrPGsvigpqqkf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 839-914 6e-14 46.6 In-house 221-295 (297) alignment 
Range on Protein: 839-914
Range on HMM: 221-295/297.0
SSAANPTDAgPIIVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWL
  |. | .| ...|||||||||.|  .  |..|.... .   .|  .|. .| ||  |||| ||. ...|. |. |
lraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 843-913 3.9e-14 47.0 In-house 243-314 (319) alignment 
Range on Protein: 843-913
Range on HMM: 243-314/319.0
NPTDAGPIIVHCSAGVGRTGTYIVIDTMLKQMQAE-EKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEW
.  . ||..|||| ||||||. |  |  .....   . |..   .  .| .|   |.| ||| ||. || |.
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 846-915 8.7e-09 29.2 In-house 264-345 (349) alignment 
Range on Protein: 846-915
Range on HMM: 264-345/349.0
DAGPIIVHCSAGVGRTGTYIVIDTMLK--QMQAEE--KV--------NVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLR
.  ...|||||| ||||... .| .|   ..  .|  |.         ..  .  .| ||  .||   |...|.. ||....
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 851-917 1.5e-15 51.4 In-house 2-68 (69) alignment 
Range on Protein: 851-917
Range on HMM: 2-68/69.0
IVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
.||||.| |||||.| |   . ....|  |..|  .. .|  |  .|  | .|.|||| | | |. |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 851-917 4.8e-15 49.7 In-house 1-67 (69) alignment 
Range on Protein: 851-917
Range on HMM: 1-67/69.0
IVHCSAGVGRTGTYIVIDTMLKQMQAEEKVNVFGFLKRIRTQRNYLVQTEEQYVFIHDVLLEWLRAG
.||||.| |||||.| |   . ....|  |..|  .. .|  |  .|  |..|.|||| | | |. |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
0051299 (Phosphotyrosine protein) phosphatases II 917-1214 2.3e-59 196.6 In-house 1-283 (288) alignment 
Range on Protein: 917-1214
Range on HMM: 1-283/288.0
GNTVVKSTELRQYVDRMTlpdEVGRVVLDEQFNLIMKMK-PRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNEYIVT
|.| .. .||...| ...     |   | |.|. ..... .... ...  . ..||| .|..| ..||| .| ..|   ..|||||...||......|.|
gdteisveellklvlkll...angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIat

QYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTnvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKEF--DDDDQL
|.|  .|.||||.|.||.|...||.||. .    |. . |||.  ...||.| .|.||..  .              .  |.. | ..|...   |.  .
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.............lddytvrtlevtnldlldgdgesr

NVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNEflersnkETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDY
.|...|.  ||| . |  .   .|.. .|.| ..        . ||. || . |   .|||.|| .|.. . .|. ||....|| .  .||..... | |
tvthfhytnwpdhgvpdspellldflrlvrkala.......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqy

YYLFKALQ
.....|| 
rfvyeall
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 917-1215 2.4e-46 153.3 In-house 1-288 (298) alignment 
Range on Protein: 917-1215
Range on HMM: 1-288/298.0
GNTVVKSTELRQYVDRMTL-PDEVGRVVLDEQFNLIMKMKP----RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNE
||| .....|.. . ...    . . ......|. . ...       .| ..... |.||| .|.|... ||| .. . .     |||||||..|...| 
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTNVDEplTLGALTItlwkrntlispssqgKFLGQSSQGTHTPLVIQNKEFDDDD
.|.||.|  ||.||||.|..|....||| ||. .  |.   . |||..  |  | | .|.               . | . ...  .   .. .. . ..
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitv...............sllskeefadlivrklkvskkkeek

QLNVRQYHCSYWPDCCSPLHTA--FDLIYAVQKrnefLERSNKEtvGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSRE
. .||| | . ||| . | ..   .||.  |..     .. ...   |..|.  .|   .|||.|.... . . .|. ||....||   .|||......|
erevrqlhftsWpdkgvpenatsvldllrkvra....sqqqagn..kpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqtee

DYYYLFKALQS
.| ....| . 
qYvfiyeavle
subfamily_PTPRB_pd Subfamily PTPRB 921-1217 2.6e-39 130.0 In-house 7-285 (293) alignment 
Range on Protein: 921-1217
Range on HMM: 7-285/293.0
VKSTELRQYVDRMTLPDEVGrvvLDEQFNLIMKM-KPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPS
.| ... ..|..|.  ....   . |... . .. | .  ..... . . |||  ...| . ||| .. . . .   ||||....||. ..|.|.|| | 
iklekfeehvkkmkadsdlr...fseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

AETMEDFWKMLWEHNSTTIVTLTD---DQKEDEPIYWPTNvDEPLTLGALTITLWKRNtlispssqgkflgQSSQGTHTPLVIQNkefdDDDQLNVRQYH
 ||..|||.|.||..|..|| ||.     |.    |||.. .|| . | ...|| . .             . .. .   | |..    .... .|||||
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad.eepvlyGdikvtlvaee.............eledwvirelkiek....ekeerkvrqyh

CSYWPDCCSPLHTAfDLIYAVQKRNEFLERsnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
   |||   | .|.  |.  |.. .| .|.  ... .||.||  .|   .||| || .| |.. .|. |||. .|     .| .|. . ..| .. ....
ftsWpdhgvPektk.tlldfvrtvreaiek..taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvl

SCH
.  
dll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 923-1227 2.6e-44 146.6 In-house 7-296 (319) alignment 
Range on Protein: 923-1227
Range on HMM: 7-296/319.0
STELRQYVDRMTLpdeVGRVVLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAET
  ||.... ..      |   |...|.|. . .. ... ..  . |.|||  ......|.|| .| ..||.|  ||||||..||......| || | ..|
vqeLkerlkalas...tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

MEDFWKMLWEHNSTTIVTLTDDQKEDEPI---YWPTnvDEPLTLGALTITLWKRNTLispssqGKFLgqssqgtHTPLVIqNKEFDDDDQLNVRQYHCSY
.||||.|.||..| ..| ||... . .     |||.   .. . | |..|| ... |       ..           | . ||  .. .  .| ...   
iedfWrmvWeeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeeel......edyi.......irklkl.nkkssevetRevkhfqyte

WPDCCSPLHTA--FDLIYAVQKrnefleRSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
|||   | ..    ||.  ..|        .|.. |||.||   |    |||..|.   . . .|...|...||.   ..|. ..   | | ....||  
WpdhdvPekatslldllkrirk......srektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle

---CHSAELQIRSLR
   . ..|.... ||
aveagdteievqdlr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 923-1213 6.7e-29 95.6 In-house 4-275 (439) alignment 
Range on Protein: 923-1213
Range on HMM: 4-275/439.0
STELRQYVDRMtlpDEVGRVVLDEQFNLIMKMKPR---DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPS
 .|....|...   |   . ...| |. |  ..|    .  .     .. |||  |. . . .|| .  .|||    |||| ...||  .. || ||.|.
rdefqehvekl...dknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpk

AETMEDFWKMLWEHNSTTIVTLTDD---QKedepiYWPTNVDepLTLGALTITLwKRNTLIsPssqgKFlgqSSQGthtpLVIQNKEFDDDDQLNVRQYH
 || .|||....|....|||.||.     |     |||.. .     | ...    ||  . |    ..     .|    . . |.    . .  | |.|
kettddfwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrv.drniel.p....ny...virg....fkvfnerdttekertvlqfh

CSYWPDCCSPLHTAF--DLIYAVQKRNeflersNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA
   |||   | ....  |.. |..  |      .|| .||. ||  .|  ..||  ||    ...  |. |||   ||.   .| ... .  .| ....|
yiawpdknvpaqashvldflrainsan......dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyna

L
.
v
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 926-1227 4.1e-48 159.1 In-house 7-293 (318) alignment 
Range on Protein: 926-1227
Range on HMM: 7-293/318.0
LRQYVDRMTLpdeVGRVVLDEQFNLIMKMKPRDYEF-SKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAETME
|.. | |.      |...|.|... . . .    .. |     |.||| ..... ...|| .. . |. |  ||||....||||...|| .| | .||.|
leshvrrlre...sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetie

DFWKMLWEHNSTTIVTLTDDQ---KEDEPIYWPTnvDEPLTLGALTITLWKRNTLispssqgkflgqsSQGTHTPLVIQNKEFddDDQLNVRQYHCSYWP
|||.|.|| ||..||.||. .   |.    |||   ... ..|.|...| .. .|             |. .   . ....|   ... .|||||.  ||
DfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevel.............sdyvlrefkvtrtee..eesrqvrqyhytsWp

DCCSPLHTaFDLIYAVQKRNEFlerSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC-HS
|  .| ..  .|.  |.. ..     .|...|||.||  .|  ..|.|.|...| . . .|. ||...|||    .|. ..  .. | .....|.   .|
degvpesg.aslldlvrqvska...qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas

--AELQIRSLR
  .| . . ||
gdtevdasdlr
0043336 (Phosphotyrosine protein) phosphatases II 927-1213 4.3e-54 179.2 In-house 5-273 (278) alignment 
Range on Protein: 927-1213
Range on HMM: 5-273/278.0
RQYVDRMTLPDEVGRVVLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDF
 ......  .   .. .| ..|  ....|. .|....  ..|.||| .| .| ..||| .| ..|.  ..|||||.. ||......|.||.|. ||.|||
kdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedF

WKMLWEHNSTTIVTLTDDQ---KEDEPIYWPtnvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNkeFDDDDQLNVRQYHCSYWPDC
|.|.||...||||.||..    ..    |||   ...|| | .|.||.| ..              .  |.. | . |    |.  . |..||.  ||| 
wrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.............lddytvrtlevtn..lgdgesrtvthyhylgwpdh

CSP--LHTAFDLIYAVQKRNEflersnkETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
. |  | . .|.. ||....|          ||. || . |   .|||.|| .|.. . .|  ||....|| .  .||. ... . |..|..||
gvpeslsllldflkavreale.......dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 930-1216 4.7e-41 135.7 In-house 9-278 (288) alignment 
Range on Protein: 930-1216
Range on HMM: 9-278/288.0
VDRMTLPDEVGRVVLDEQFNLIMKMK-PRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAETMEDFWK
|.. .  .  .|  . |..| . ...  .. . ..  . ..|||  . .|..  || . ... ..|  |||||...|......|| || | |.|..|||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MLWEHNSTTIVTLTDD---QKEDEPIYWPTNvDEPLTLGALTITLWKRNTLISPsSQGKFLGQssqgthtplviqnkefDDDDQLNVRQYHCSYWPDCCS
. .|....||| ||.    .|.    |||.. |.|   | .|.|| . ..| .   . |.| .                 . ..|.. ||.   |||   
lvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledf.vlrkllle................kkkteleitqyqylaWpdhgv

PLHTAfDLIYAVQKrnefLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC
|  .| .|.  ...    .. .|.. .|||.||   |  ..||| || .| ... .|. .|.  ||.    .|..|.   . | .....| | 
Peska.pllellrq....vkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_PTPN6_pd Subfamily PTPN6 937-1216 8.3e-34 112.0 In-house 21-296 (306) alignment 
Range on Protein: 937-1216
Range on HMM: 21-296/306.0
DEVGRVVLDEQFNLIMKMKPRDYeFSK----ARQSKHKNRDMDLIPVERSRVPISgVPGVDG--YINASFLQGYR--RQNEYIVTQYPSAETMEDFWKML
.....  . |.|. . ... ... .|.      . |.|||    .|.. .|| ..  |.| |  ||||.....     ...|| ||    .|..|||.|.
eslekagfeeefeelqqeeakkl.lsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmv

WEHNSTTIVTLTDDQK---EDEPIYWPTNVDEPLtLGALTITLWKRNtlispssqgkflgQSSQGTHTPLVIQNKEFDDdDQLNVRQYHCSYWPDCCSPL
|. ||. || .| .     |    |||.. ...   | ...|  . .             . .. .   |....|.... .. .|.|||   |||   | 
wqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek.............sladYilRelsvskkkkkk.eerevfqyhfksWPdhgvpk

HTA--FDLIYAVQKRNEFLERSnkeTVGPITVHDRSGGCQAGTFCALSTLHQEMIH---EEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC
..    |..  |....| ||..   . ||| ||  .|    |||  . .| . . .   .  .||.|.||.  . |  |.   . | ...||..  
dpgavLdfledvnrkqeeleea...eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
0050432 (Phosphotyrosine protein) phosphatases II 939-1214 1.5e-58 194.0 In-house 39-296 (308) alignment 
Range on Protein: 939-1214
Range on HMM: 39-296/308.0
VGRVVLDEQFNLIMKMKP-RDYEFSKARQSKHKNRDMDLIPVERSRVPIsgvPGVDGYINASFLQGY--RRQNEYIVTQYPSAETMEDFWKMLWEHNSTT
 ..  |.|.|. ....|| ..|....  . |.||| .| .| ..||| .   .. ..|||||. .||  ......|.||.|  .|.||||.|.||.|...
ldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVTLTDDQKED---EPIYWPTNVD-EPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKEFDddDQLNVRQYHCSYWPDCCSPL--HTAF
||.||. .  .    . |||.... ..|. | .|.||..  .              .  |.. | ..|.. .  . . |...|.  ||| . |      .
IvmLtklvengrekcaqYwplelgggsleygkftvtllseev.............lddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeill

DLIYAVQKRNeflerSNketvGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
|.. .|.|..     ..    ||| || . |   .|||.|| .|.. . .|  ||....||    .||. ... | |..|..||.
dflelvrksl.....pg....gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall
0047943 (Phosphotyrosine protein) phosphatases II 939-1213 8.5e-57 188.0 In-house 9-268 (273) alignment 
Range on Protein: 939-1213
Range on HMM: 9-268/273.0
VGRVVLDEQFNLIMKMK-PRDYEFSKARQSKHKNRDMDLIPVERSRVPIsGVPGvDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIV
 |. .| |.|.|....| . .|....  . |.||| .|..|...||| . | .| ..|||||...||......|.||.|  .|.||||.|.||.|...||
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdgg.sdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

TLTDDQKE---DEPIYWPTNVDE-PLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKEFDDddQLNVRQYHCSYWPDCCSP--LHTAFDL
.||...     . . |||....| .|| | .|.||.. .|              .  |.. | ..|.....   . |...|.  ||| . |  |   ...
mLtelvelgrekcaqYwpleggelsltygkftvtllseet.............kddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllef

IYAVQKRNEFLERSnketvGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
| .|.| .| | ..     ||. || . |   .|||.|| .|.. ...|  ||....|||.  .||. ... | |..| .||
ielvrkalealpsn.....gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 939-1214 6.5e-14 46.6 In-house 13-274 (307) alignment 
Range on Protein: 939-1214
Range on HMM: 13-274/307.0
VGRVVLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVT
 |   | ..|. . |..|        .   .|||  |.  ....|. .        || | .|    . . .|..| |  .|. .|| |  ...  ... 
kgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LTD---DQKEDEPIYWPTNVDEPLTLGALTITLWKRNTlispsSQGKFLGQSSQGTHTPLVIQnkefDDDDQLNVRQYHCSYWPDCCSPLH--TAFDLIY
| .     |     ||| .  . |. |  . |.   |        .|.  .      | | ..      ..   ....  . |||   |    || .|. 
lckvielakikceqywpleegqklvfgeapntisvanl.....gakklapdedlinvttlkvd....waqksrtiqhlqwenwpdrgvpqinltainlle

AVqkrneflersNKETvGPITVHDRSGGCQAGTFCALSTLHQEMIHE-EAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
||          . .|  |. ||  .|  ..||  |.| . . ||   .  |. | |.   ..|.  | .   | || . | 
av..........rydt.npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvll
0039614 (Phosphotyrosine protein) phosphatases II 940-1214 6.5e-53 175.5 In-house 30-286 (297) alignment 
Range on Protein: 940-1214
Range on HMM: 30-286/297.0
GRVVLDEQFNLIMKMKPrDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV---DGYINASFLQGYRR-QNEYIVTQYPSAETMEDFWKMLWEHNSTT
.. .|...|  ....|| ||....  ..|.||| .| .| ..||| .....||   . |||||...||.. ....|.||.|. ||.||||.|.||...|.
sktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtv

IVTLTDDQKED--EPIYWPTNVDeplTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNkefdDDDQLNVRQYHCSYWPDCCSP--LHTAFDL
||.||.    .   . |||....   | | .|.|| |  .              .  |.. | ..|    ..  . |.....  ||| . |  | . ...
ivmLtklvelgrkcaqywpeegg...tygdftvtllkveh.............ldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslelllef

IYAVQKRNEFLersN-KetvGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
. .|..... |   . .   ||. ||   |   .|||.|. .... . .|  ||....|| .  .||. ... . |..|..||.
lelvrealael...pkg...gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0040438 (Phosphotyrosine protein) phosphatases II 941-1215 1.1e-55 184.5 In-house 17-274 (317) alignment 
Range on Protein: 941-1215
Range on HMM: 17-274/317.0
RVVLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVT
  .| |.|. ....|. .|....  ..|.||| .| .| ..||| .| ..|.  ..|||||. .|.......|.||.|  .|.||||.|.||...|.||.
ftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LTDDQ---KEDEPIYWPTnvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKefDDDDQLNVRQYHCSYWPDCCSP--LHTAFDLIY
||.     .|    |||.  .|.|| | .|.||..  .              .  |.. | ....  .|.... |...|.  ||| . |  . . .|.. 
LteleelgrekcaqYwpl..getltygdftvtllseee.............lagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfle

AVQKRNEflersnkETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
||.. .|       .  ||. ||   |   .|||.|. .... . .|. ||....|| . ..||. ... | |..| .||. 
avreale.......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle
subfamily_CG7180_pd Subfamily CG7180 941-1214 1.5e-39 130.4 In-house 16-287 (296) alignment 
Range on Protein: 941-1214
Range on HMM: 16-287/296.0
RVVLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVT
||  . ...|. ...  |       . . |||| . .| .  || .. . |   . ||||.. ... ...|||||. |  ||...||........ ..| 
rveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvv

LTDDQK--EDEPIYWPTNVdePLTLGALTITLWKRNTLISPSSQGKFLGQSsqgtHTPLVIQNKEFDDDDQLnVRQYHCSYWPD-CCSPLHTAfDLIYAV
||.     .  | ||| .       | . . . . ...    ..   | .        |  |.|. . .  . |....   |.     || |.  ||. .
Ltktfdfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkk....ivalteqekqvkaetRi.vklfqlteWeledkvPlstn.alielr

QKRNEFLERS-NKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
.. . . |.  .... ||. |.   |.  .| ..|.    . ...|| ||... ||    .||.|. . |.| |..  |.
rrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_PTPN9_pd Subfamily PTPN9 941-1213 7.4e-32 105.6 In-house 15-286 (297) alignment 
Range on Protein: 941-1213
Range on HMM: 15-286/297.0
RVVLDEQFNLIMKMKPR-DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIV
.  | ...  | ....   .. || |   .|||  |.. ....|| .. |.. .   ||||.|..||.... .| || |  .|..|||.|.||..  .||
krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

TLTD---DQKEDEPIYWPTNVDEPLTLGALTITLwkrntlISPSSQGKFlgqssqgTHTPLVIQNKEfdDDDQLNVRQYHCSYWPDCCSPLHT--AFDLI
  |     ..     |||.. ..    | |...       ..  .. ..       ... |.|.| .  .... .|  .    |||   |  .   .|..
mttrvvergrlkcgqyWpleeessaefgdlsvsn......veveeeedy.......kvrvleiknvk..teesrkvthfqflsWPdyGvPssaaslldvl

YAVQKRNE-----FLERSNKETV-GPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 .|...       . .... ..   || ||  .|  ..|||..|    ... ... ||. .||||  ..|   |   | |.. ..|.
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_PTPRG_pd Subfamily PTPRG 942-1219 2.5e-103 341.2 In-house 19-289 (563) alignment 
Range on Protein: 942-1219
Range on HMM: 19-289/563.0
VVLDEQFN-LIMKMKPR--DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG---YINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTT
. ..|.|. |.......  |.|.|.....|.|||........|||| .|..||...   ||||....||......|.||.|...|..|||.|.||.|...
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVTLTD---DQKEDEPIYWPTnvDEPLTLGALTITLWKRNTLISPSSQgkflgqssqgthtPLVIQN---KEFDD-DDQLNVRQYHCSYWPDCCSPLHTA
||..|.   ........|||.  ||..|.|||..||.....|......              |||.|   |.... |....|||||...|||...| |..
ivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvr.............tlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl

FDLIYAVQKrneflERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCHSA
..||.....     ...||...|||.||...|....||...|.||.... .|.||......| ..|.|..|....|.|..|..||... ..
pvLifvkks.....saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPN23_pd Subfamily PTPN23 942-1212 1.9e-31 103.9 In-house 15-275 (288) alignment 
Range on Protein: 942-1212
Range on HMM: 15-275/288.0
VVLDEQFNLIMKM---KPRDYEFSKARQSKHKNRDMDLIPVERSRVPISgvPGVDGYINASFLQGYRRQ-NEYIVTQYPSAETMEDFWKMLWEHNSTTIV
 .||..|... .    . |.   . |.   .|||  |..| ...|| .    . | ||||||...   .  ..|.|| | ..|. |||.|..|  | .||
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviV

TLTDDQKEDEP---IYWPTNVDEPLTLGALTITLWKRNtlispssqgkflgqsSQGTHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCSPL--HTAFDLI
 |.. .. ..|    |||.. .|. . |.|..|| . .               . .||   |.. .  | |   .|.  .   ||.   |   .| ....
mllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr...............etethvervlkletldadavksvshlqltsWpelGvPasPetllqfl

YAVQKRNEFLERSNKEtvgPITVHDRSGGCQAGTFCALSTLHQEMIHEE-AVDIYKTVKLYAAKRPNLITSREDYYYLFKA
 .|..  |  .|  |    |. ||  .|   .|.|. . .  .|. ...  .|| . |.   ..| . .  .| .  ...|
devesayeavqrkskt...PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyea
subfamily_PTPRD_pd Subfamily PTPRD 943-1227 5.2e-56 185.4 In-house 24-294 (564) alignment 
Range on Protein: 943-1227
Range on HMM: 24-294/564.0
VLDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT
 ..|... | . .    | ... . |.|||  . .. ..||| .| |.|..|  ||||||..|||....|| || | |||.||||.|.||.||.||| ||
kfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmlt

DDQKEDE---PIYWPTNvDePLTLGALTITLWKRNTLISPSSQGKFLgQSSQgthtplviqnkefdDDDQLNVRQYHCSYWPDCCSPLHTaFDLIYAVQK
  . ...     |||.. . . | | ||.|| . ..|   .    .| . ..              .... .|||.|   ||| . | ..  .|.  ..|
kleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkk..............ssesreVrqFhFtsWPdhgvpesa.tslLdlirk

---RNEflersnkETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ---SCHSAELQIRSLR
    ||       .. |||.||  .|    |||.... . . . .|. ||||..||.  ..|. .. ..| | ....|..   .| . |.....|.
vralne.......pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlk
0045450 (Phosphotyrosine protein) phosphatases II 943-1213 1.1e-51 171.7 In-house 28-300 (307) alignment 
Range on Protein: 943-1213
Range on HMM: 28-300/307.0
VLDEQFNLIMKMKP---RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV---DGYINASFL--------QGYRRQNEYIVTQYPSAETMEDFWKML
 | ..|. ......    .|....  ..|.||| .| .| ...|| .| ..|    ..|||||.         .||......|.||.|  ||.||||.||
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

WEHNSTTIVTLTDDQKEDEP---IYWPTNvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKeFDDDDQLNVRQYHCSYWPDCCSP-
||...|.||.||..   . .    |||.. .|.|| | .|.||.. ..              .  |.. | ....   ..  . |...|.  ||| . | 
weqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.............ldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvpp

-LHTAFDLIYAVQKRNEFLERSnketvGPITVHDRSGGCQAGTFCALSTLHQEMIHEEA---VDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 . ...|.| .|.| .| | ..     ||. || . |   .|||.|. .. . . .|.    ||....|||. ..||. ... | |..| .||
sfeelldfieevrkaleelpkg.....gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0045098 (Phosphotyrosine protein) phosphatases II 943-1215 4e-48 159.6 In-house 10-270 (278) alignment 
Range on Protein: 943-1215
Range on HMM: 10-270/278.0
VLDEQFNLIMKMkPRDYEFSKARQSKHKNRDMDLIPVERSRVPisgvpgvdGYINASFLQGYrrQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD-
 |. .|.|..   | .....  . ...||| .| .|...|||         .|||||...||  ....|.||.|  .|..|||.||||...|.||.||. 
llefefllllgi.pseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

--DQKEDEPIYWPTnvDEPLTLGALTITLWKRNTLispssqgkflgqsSQGTHTPLVIQNK--EFDDDDQLNVRQYHCSYWPDCCSPLHTAF-DLIYAVQ
  ...|  . |||   ...|| | .|.||..  .|             .  |.. | ..|   |. |. ...|...|.  ||| ..| ..    .. ...
velgrekcaqywpe..ggsltygdftvtllseevl.............ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflelle

KRNEFLER-------------SNketvGPITVHDRSGGCQAGTFCALSTLHQEMihEEAVDIYKTVKLYAAKRPN-LITSREDYYYLFKALQS
  .|.|..             |.    ||. || . |   .||..|. .. . .  |. ||....|| .  .||.  ... | |..|...|. 
firealkllaslllsslllldsg....gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 943-1215 3.9e-33 109.7 In-house 21-276 (287) alignment 
Range on Protein: 943-1215
Range on HMM: 21-276/287.0
VLDEQFNLIMK--MKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPgvDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT
   .|| .. .   .. .   . | | |.|||  .... .  ||.. |    . ||||.|..||. ....|... | ..|. .|||.....| |.|| |.
gfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgeh..pdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlc

DDQKEDEPI---YWPTNVDepLTLGALTITLWKRNtlIspssqgkflgqSSQGTHTPLVIQNKEfDDDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVQK
... .|| .   |||..    ..||  .|.| ...  .           ... .   | ..||.  ..|...|.||.   |..     . .   .  ...
qekendeevcyqyWpeeks..vvlGeyniellnee..v...........nagyierklevknkn.kagdkqqvkqyqitnWdstgkvtepq.tillviee

RnefLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
.        |.. ..| ||   .  ....|||  |  ..   | ..|... .|    ..|. .   | | ....... 
m...yktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivle
0046845 (Phosphotyrosine protein) phosphatases II 944-1215 8.1e-58 191.4 In-house 2-272 (284) alignment 
Range on Protein: 944-1215
Range on HMM: 2-272/284.0
LDEQFNLIMKMKPR---DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV---DGYINASFLQGY-----RRQNEYIVTQYPSAETMEDFWKMLWEHN
|.|.|  ......    ....... . ..||| .|..| ..||| .. ..|    ..|||||...||     ......|.||.|  .|.||||.|.||.|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STTIVTLTDDQKED---EPIYWPTNvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKefD-DDDQLNVRQYHCSYWPDCCSP--LH
...||.||.    .    . |||.. .|.||.| .|.||.....              .  |.. | ..|.  . ..  . |...|.  ||| . |  . 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.............kddytvrtleltnl..gytgesrtvthfhytswpdhgvppspe

TAFDLIYAVQKRNEFlersnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEE---AVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
  .... .|.. .|       .. ||| ||.. |   .|||.|| .|.. ...|.    ||....|| .  .||. ... | |.....||. 
dlleflrlvrellen.....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealle
DSPc_SM00195 944-1215 3.5e-53 176.0 In-house 2-260 (263) alignment 
Range on Protein: 944-1215
Range on HMM: 2-260/263.0
LDEQFNLIMKMKPRDyEFSKARQSK--HKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTL
|.|.|. ...... . |...|...|  .|||  . .|....|| ..  ..   . ||||....|......||.||.|  .|.||||.| ||.....||.|
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TDDQK---EDEPIYWPTNVDEPLTLGALTITLWKRNTLIspssqgkflgqsSQGTHTPLVIQNKEFddDDQLNVRQYHCSYWPDCCSP--LHTAFDLIYA
|....   |    ||| . ... | | ....|.. ..              .. . . | .....   ... .|.||..  |||   |   .  ..|. |
teeeengkekcdrywpeesggketfgkisvklvevekkk............deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellra

VQKRNEFLersnketVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
|.|...          ||| ||   |  ..|||...... ... .|. ||| ..||    .||......| | .. .|.  
vkksksts.......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 944-1215 3.5e-53 176.0 In-house 2-260 (263) alignment 
Range on Protein: 944-1215
Range on HMM: 2-260/263.0
LDEQFNLIMKMKPRDyEFSKARQSK--HKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTL
|.|.|. ...... . |...|...|  .|||  . .|....|| ..  ..   . ||||....|......||.||.|  .|.||||.| ||.....||.|
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TDDQK---EDEPIYWPTNVDEPLTLGALTITLWKRNTLIspssqgkflgqsSQGTHTPLVIQNKEFddDDQLNVRQYHCSYWPDCCSP--LHTAFDLIYA
|....   |    ||| . ... | | ....|.. ..              .. . . | .....   ... .|.||..  |||   |   .  ..|. |
teeeengkekcdrywpeesggketfgkisvklvevekkk............deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellra

VQKRNEFLersnketVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
|.|...          ||| ||   |  ..|||...... ... .|. ||| ..||    .||......| | .. .|.  
vkksksts.......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 944-1215 3.7e-41 136.2 In-house 24-281 (305) alignment 
Range on Protein: 944-1215
Range on HMM: 24-281/305.0
LDEQFNLIMKMkPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT-
|..|......  .  ..  |  ..|.|||  . .. . .|. ..  . .|   |||||...||.|...|||.| |  .|..|||....|   .||| || 
leaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk

--DDQKEDEPIYWPTNVDEPLTLGALTITLWKRNTLispssqGKFlgqssqgTHTPLVIQNKEFdDDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVqkr
  ...|.    |||... |.  .| ....|  ..|         .       .   | | ...  |... .| ||.   |||   |  ..  |.  .   
lveggkdkCrqYWpesktekkefgefsvelksekta......sdy.......ieRklkisiede.dkesrtvlqyqltdWPdhGvpqfat.sllsli...

NEFLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
..  .. .|.   |..||   |   .|.|.|..   . . .|| ||... .|    ||...... . | .|. ||. 
krvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 944-1214 4.9e-25 82.8 In-house 17-290 (301) alignment 
Range on Protein: 944-1214
Range on HMM: 17-290/301.0
LDEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV----DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTL
..||.. . .....  . .   . |. ||  .  ...  |. ..  | .      |||||...||......|..| |  .|. |||...|..  ..||..
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmv

TDDQ---KEDEPIYWPTNVDEPLTLGALTITLWKRNTL---ISPSSQGKFLGQSSQGTHTPLVIQNKEFdddDQLNVRQYHCSYWPDCCSplhtAFDLIY
|. .   |.    |||.   |  . | .|.|| . ...   .  . . |    |..|     .  ....   .  .| |..   ||.         .   
tnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGv....vreprt

AVQKRNEFLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
 .|  .. . | .|   ||. ||   .  ..|..|..|        |  ||... .|    ..|  .|  | |  ......
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 944-1225 1.6e-24 81.4 In-house 8-265 (267) alignment 
Range on Protein: 944-1225
Range on HMM: 8-265/267.0
LDEQFNLIMKMKPRDYE--FSKARQSKHKNRDMDLIPVERSRVPISGVPgvDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD
....|.|| |. .       | | . . .||  | .| . .||...     . |||||...||...| .|||| |   |. ||.... ... ..|| || 
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke..eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

DQKEDEPIYWPTNVDEPLTLGALTITlwkrntlispSSQGKflgqssQGTHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCsPLHTAFDLIYAVQKRNEf
  ... . .|| .. .      ||.            |  |      .     ..  . .| ..   ||  |.   |       .  .  ....  .|. 
vftdnirlfwPPkmgqakkyqdltve..........hslek......eendyqiitlelkfknesahnvtlyyykkwnint.nnkpylkplfgilaknq.

LERSNKetvgPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALqsCHSAELQIRS
||  |.    |. |.   |  ..|||  . .  . . .|. .||.. ..    .|. |. ..| | |. . |  .. || ... 
lengnr....PlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell..aeyaegrlke
subfamily_PTPN13_pd Subfamily PTPN13 945-1213 3e-28 93.9 In-house 14-265 (273) alignment 
Range on Protein: 945-1213
Range on HMM: 14-265/273.0
DEQFNLIMKMKPRDY-EFSKARQSKHKNRDMDLIPVERSRVPISGVPGvdgYINASFLQGYRRQN--EYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD
.|.|. . ..|| |  | .| .. |.|||  ...|....||....  |   |||||...    ..  |||..| |  ||..|||.|.|| ... |. .| 
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

DQKEDE---PIYWPTNVDEPLTLGA-LTITLWKRNTLispssqGKFLGQSsqgthtplvIQNKEFDDDDQLNVRQYHCSYWPDCCSPlHTAFDLIYAVQK
.. ...     ||| . ...|..   |...| | . |        |  ..         .. |. .  .  .| . .   |||   |  .| .|.  |..
ekekgkvkchrywPesknkklkvsnrlevellkvqkl......dgfvvra.........lavkdsesgesrevahlnfvkwPdhgvP.ssaaellqfvae

RNEFlersnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 ...     ..  ||| ||  .|  ..||. .. .. . . ... .|. ..|.    .|  .. ... | . .||.
vrrl.....qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 945-1014 6.3e-06 20.3 In-house 26-94 (95) alignment 
Range on Protein: 945-1014
Range on HMM: 26-94/95.0
DEQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDgYINASFLQGYRRQNEYIVTQ
|..|. |       |    .     ||| ....| . .|| ..     | |||| |..|| |.| || .|
dnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrdsd.yinacfvdgyarkncyiaaq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 946-1216 1.2e-32 108.3 In-house 27-287 (325) alignment 
Range on Protein: 946-1216
Range on HMM: 27-287/325.0
EQFNLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISG--VPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKML--WEHNSTTIVTLTD
 .|.|.    .  .. .   . | |||  .......||| .      .   |||||.|. ..... .. .| | ..|..|.|...  |.     ..   |
hefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneld

DQKEDEPIYWPTNVDEPLTLGALTITLWKRNTLiSpssqgkflgqssQgtHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCSPLHTAfDLIY---AVQKR
 .|.   .||| .. .  |.|.| . |   ... |               .   |.. |. .. . . |.|..   |.|   . . |  ||     |.. 
lgkdrcavywpkemgksktfGglevklrtieei.s............d..yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpa.tlisilqlvkav

NEFLeRSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC
.| . ..| .. .|| ||  .|  ..|.| .| .. ...|.|  |||.. ||   ..||... . . |  ...||   
serv.tantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 946-1215 3.8e-29 96.6 In-house 10-266 (274) alignment 
Range on Protein: 946-1215
Range on HMM: 10-266/274.0
EQFNLIMKMKPRDYEFSkarQSKHKNRDMDLIPVERSRVPISGVPGVD---GYINASFLQGYRRQ-NEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD
| ..| . ....... .    |..|||  ...| |.||| ..   . |    |||| ...||... . |. || | ..|..|||.|....... || ||.
eflelPlnfdqeeldvf...gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

DQKEDE---PIYWPTNVDEPLTLGALTITlwkrntlispsSQGKFLGQSSQGTHTPLVIQNKEF--DdddqlnVRQYHCSYWPDCCSPLHtAFDLIYAVQ
 . ..|     |.|.. |  ..     .             . .   .  . . . ||... |   .      |  |  . |||  || . |  |.  |.
lkeaneqkCavyfPdaedyeiserygdve...........ikvekiverndysvrklvlkylerers......vkhywytdWPdhksPdd.antlldlvl

KRNEFlERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
. .|  ...... ..|. ||  .|  ..| | | |   ... .|. ||. |.|     .|  .. ..| | ....||  
evees.reeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPN3_pd Subfamily PTPN3 946-1213 1.4e-23 78.2 In-house 19-271 (280) alignment 
Range on Protein: 946-1213
Range on HMM: 19-271/280.0
EQFNLIMKMKP-RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGvdGYINASFLQ----GYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT
 ||. . . || .. . ..  .  .|||  |..| .  || ..  .    ||||....    .    | ||.|| | |.|..|||.|.||..|..|| ||
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

DDQKE---DEPIYWPTnVDEPLTLGALTITLWKRntlispSSQGKFLgqssqgtHTPLVIQNKEFDDDDQLNVRQYHcsYWPDCCSPLHTAfDLIYAVQK
.   .       |||.  .. |..| ..... |.      ... ...          ||...|| ... ..   ||    ||| . | ..| |..  |..
tlverGrvkChqyWPe.tedeleygefsvkceke......detksyv.......lrelvlkdketkeerkilqlqyl..aWpdhgvPddsa.dflefver

RNEFLersnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 ..      . .  |. ||  .|  ..| . .| |  . . ..|.| . . |.    .| .|. . . | .. .|.
vrklr....sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 947-1211 9.4e-12 39.3 In-house 33-281 (305) alignment 
Range on Protein: 947-1211
Range on HMM: 33-281/305.0
QFNLIMKMKprdyEFsKARQSKHKNRDMDLIPVERSRVPISGvPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK--
.|| . |||     | |  | ..|||  |.  ... || . | |    || | ..      . .| || |  .|  ||| | ....  .|  | . ..  
rfndfekmk....af.keaqeagknrykdvgcldnnrvkleg.pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekg

-EDEPIYWPTNVDEPLTLGALTitlWKRNTLISPSSQGKFLGQSS-QGTHTPLVIQNKefdDDDQLNVRQYHCSYWPDCCSPlhTAfDLiyAVQkrnEFL
 .    |.... .. |..        |    .  |.. ||  ... . |.| |||.       ... | .||   |||   |  .| ||  |.    |.|
akkcleyfaskdkdvlefeekg...qkisvkfessvtlkfrkdakakvtetvlviegp...gekarkvthyhwidwpdrgvp..aa.dl..ail...ell

ERSnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVD-IYKTVKLYAAKRPNLITSREDYYYLFK
|.. . . |||.||  .|  ..|.   |  . ....  . ..   | ..    .| | | . ..| .. .
eka.rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhq
subfamily_PTPN14_pd Subfamily PTPN14 948-1213 1.4e-21 71.8 In-house 29-292 (300) alignment 
Range on Protein: 948-1213
Range on HMM: 29-292/300.0
FNLIMKMKP-RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVP-GVDGYINASFLQGY--RRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDD-
.. |.|..   ... .|  . ..|||. |..| | .|| .|      .|||||| ..     .. .|||.| |   |..|||.|.||.. . || ||.. 
yeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee

--QKEDEPIYWPTNVDEPLTlgaLTITLWKRNTlispssqgKFLGQSSQGTHTPLVIQNKEFDDDDQLNVRQYhcSYWPDCCSP--LHTAFDLIYAVQK-
   ||    |.| . ..  |   ..   .|  |        ||  .|.. . | | ..     .. ..   ||    |||   |  ... .. .  ||  
edgkeksfkyfPkleskkkt...vefgkfkvtt........kfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsv

--RNEFLERSnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
  . .    | ||.  |. ||   |. ..|       | . . |.| .|| |...    .|  |. .   | ...|.|
rrktnseves.keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl
subfamily_Ptp69D_pd Subfamily Ptp69D 949-1218 1.5e-43 144.1 In-house 30-287 (307) alignment 
Range on Protein: 949-1218
Range on HMM: 30-287/307.0
NLIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKED
.|  .. ... ..|.    . |||  |... .. || .. ..| .   ||||||..||. ....|. | |  .|..|||.|..| ..|.|| |.. .  .
kLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnltekn

E---PIYWPTNvdEPLTLGALTITLwkrntlISPSSQGKFLGQSSQGTHtplvIQNKEFDDDDQLNVRQYHCSYWPDCCSPLHTaFDLIYAVQKRNEFLE
.   . ||| .  .    | . ..|      .| ......  .. . ..    ....  . .|. .| |||   |.|   | ..   |.  ... .|  .
rkkcakYWpie..devqygdilvkl......vseekhsdyiiReldvsk....kkeesgevedsrkvvqyhytgWkDskvPeva.rgllklieqvrelyk

RSnketVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCHS
 .     .||.|| . |  ..|.| ||. | |..  |. |||..|||    .|. |..| | | .|..||   .|
ln....rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 950-1065 5.7e-15 49.9 In-house 16-136 (297) alignment 
Range on Protein: 950-1065
Range on HMM: 16-136/297.0
LIMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGY--RRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQ---K
|. . .. ..  .|   | .|||  |.. .. .|| . .|.    |||| ..       .  ||..| |  .|..|||....|..  .|| ..  |   .
lldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

EDEPIYWPTNVDEPLTLGALT
.    |||  |.| |. | . 
dkcapywpsvvqerlkagdvv
0036941 (Phosphotyrosine protein) phosphatases II 951-1214 2.1e-54 180.2 In-house 23-274 (297) alignment 
Range on Protein: 951-1214
Range on HMM: 23-274/297.0
IMKMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPIsgVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQ---KEDE
   ... ... ..  . ..||| .| .| ...|| .   .. ..|||||...||......|.||.|  .|.||||.|.||.|.|.||.||..    .|  
lpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekc

PIYWPTNVDEPLTLGALTITLWKRNTLispssqgkflgQSSQGTHTPLVIQNKefDDDDQLNVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNEFLERS
. |||....|.|| | .|.|| . ..             ..  | . | ....  ...... |...|.  ||| . |    . .|.| .|.|... | ..
aqywpleegesltygdftvtllsvevv...........llddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

nketvGPITVHDRSGGCQAGTFCALSTLHQEMI---HEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
     ||. || . |   .|||.|. ...| .    .|. |||...|| .  .||. ... | |..|  ||.
.....gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 953-1213 2.9e-30 100.1 In-house 19-262 (283) alignment 
Range on Protein: 953-1213
Range on HMM: 19-262/283.0
KMKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGvdGYINASFLQ---GYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD---DQKED
 . ..| . . |.. |.|||  ...|... || .   .    ||||.|.     |.....||..| |  .|. |||||..... |.|| ||    |... 
svpdldadiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrik

EPIYWPTNVDEplTLGALTITLWKRNTLISPSSQGKFLGQSsqgthtplviqnkeFDDDDQLNVRQYHCSYWpdccspL-HTAFDLIYAVQKRNEFLERS
   ||| .  |    | .|.|| |  |  | . .   | ..                  ..| .  |    |      |       | .. | |      
CsqyWPkrGse..dyGeftvtlrkettsnsfiikelllrvn..............ssakstlllahyqvidW......leygeqaiinslvkfnkvislq

NKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
...  ||| ||  .|. ....|.|.|.  ...  |  ||....||    .|. .. ... |  . .. 
teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPRN_pd Subfamily PTPRN 954-1055 1e-15 52.2 In-house 43-150 (297) alignment 
Range on Protein: 954-1055
Range on HMM: 43-150/297.0
MKPRDYEFSKARQSKHKNRDMDLIPVERSRVPISGVP--GVDGYINASFLQG-YRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDE
 .|.  | .|| .  .|||  ...| . ||| ..       . |||||..     |.  || || | |.|. |||.|.||. .. ||.||  ..   . .
aepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqc

PIYWPTNV
  ||| . 
krywpdeG
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 957-1217 7.3e-42 138.8 In-house 51-291 (319) alignment 
Range on Protein: 957-1217
Range on HMM: 51-291/319.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTddqKEDEPIYWPTN
 | .|.   | | ||| ..... ....| .  . |...  ||||||..||.|.. || .| |  .|..|||.|.||.|..||| ||   |.    ||| .
adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt...kdkcsqywplk

VDEPLTLGALTITLWKRNTLispssqgkflgqssqgthtpL-----VIQNkEFDDDDQLNVRQYHCSYWPDCCSPlHTAFDLIYAVQKRNEFLERSNkeT
...    . . ... .                               . . .    |. ...|.|   |||   | . . ||.  |.| . . .. |   
ivikeerfkvkvdsveetae....................yvvrdielse.dgkekdirkitqfhflGwpdvGvp.dypsdlmrlvkkvrhltsken..h

VGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCH
  .| ||  .|  ..|.. .| .| . | .|. ||.|..|.    .|..|. .  .|.... ||   |
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 957-1217 1.1e-41 138.2 In-house 15-255 (284) alignment 
Range on Protein: 957-1217
Range on HMM: 15-255/284.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTddqKEDEPIYWPTN
 | .|.   | | ||| ..... ....| .  . |...  ||||||..||.|.. || || |  .|..|||.|.||.|..||| ||   |.    ||| .
tdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...kdkcsqywplk

VDEPLTLGALTITLWKRNTLispssqgkflgqssqgtH--TPLVIQNkEFDDDDQLNVRQYHCSYWPDCCSPlHTAFDLIYAVQKRNEFLERSNkeTVGP
...    . . ... .                     .    . . . .    |. ..||.|   |||   | . . ||.  |.| . . .. |     .
ivikeerfkvkvdsveesee.................yvvrdielse.dgkekdirkirqfhflgwpdvgvp.dypsdlmrlvkkvrhltsken..hran

ITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCH
| ||  .|  ..|.. .| .| . | .|. ||.|..|.    .|..|. .  .|.... ||   |
ivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 957-1214 3.2e-33 109.9 In-house 36-280 (290) alignment 
Range on Protein: 957-1214
Range on HMM: 36-280/290.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV----DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PI
   .   . ..|..||  .... .  |...  ..|     . ||||....||. ...||.|| |  .|. ||||..|....| || ||. ..|..     
htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqq

YWPTNvDEPLtLGALTITLwkrntlispssqgkfL--GQSSQGTHTPLVIQNKEFDdDDQLNVRQYHCSYWPDCCspLHTAFDLIYAVQKrnEFLERSNK
|||.. |    .|  .|.|               |   . .. ... | ..||. . ... .| ||. . |..     .|.   |  | .  |  .   |
YWpds.dtka.ygefsikl...............lneetlneyierklevknknsa.gakqsvtqyqitnwdstg..kvtnpqtillvie..emyktqrk

ETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
.. ..| ||   .  ....|||. |  . .  |  .|... .|    ..|..... . | ..|. . 
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 957-1215 8.9e-26 85.5 In-house 10-262 (270) alignment 
Range on Protein: 957-1215
Range on HMM: 10-262/270.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRR-QNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIY
 . .. .| . |. || .|..|  ..|| .. .    .  |||| ...|.   ...|| .. | . |...||.|.||...|.|| .|   .. ..    |
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPTNVDEPLTLGALTITlwkrnTLISPSSQGKFLgqssqgTHTPLVIQnkefDDDDQLNVRQYHCSYWPDCCSPLHTA-----FDLIYAVQKRNEFLERS
||....| ..| . .|.     .| . ... ..         | | ..    .. .. ..  ..   |||   | ..       .|.. ...  .. .. 
Wpaepkekvkledgkik.....vlalseekeegy......iltrlrle....ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekel

NKETvgPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
.|..  |. ||.  |   .||. || .  . . ... ||. . ..    .|..|.   | | .|.||.. 
dkae..PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_ptpA1_pd Subfamily ptpA1 957-1176 3.7e-16 53.9 In-house 37-255 (418) alignment 
Range on Protein: 957-1176
Range on HMM: 37-255/418.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDG--YINASFLQGYRrQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQkEDepIYWPTN
 .      ..   |||  ...||...|| .  .   .|  |||| ...|    ...|.|| |  .|. |||.|.||     || |. .  |.       .
setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsres.en..crikcd

VDEPLTLGALTITLWKRNTLISPSsQGKFLGQSSQGTHTPLVIQNKEFD-DDDQLNVRQYHCSYWPDCCSPLHTA--FDLIYAVQKRNEFLERSNKETVg
   |  .|   ....     .  .     | .  |     .. .|  .  . .  .. ||.   |||   | ||    .|.... .|.. .  |.   | 
rywpeqiggeqfsiygngnevfgt.ysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnv.

PITVHDRSGGCQAGTFCALSTLHQE
|| ||  .|  ..||||.   . ..
piivhcsagvgrtgtfctavimmkk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 957-1179 5.4e-14 46.7 In-house 37-292 (350) alignment 
Range on Protein: 957-1179
Range on HMM: 37-292/350.0
RDYEFSKARQSKHKNRDMDLIPVERSRVPIS-----------GVPGVDgYINASFLQGY----RRQN--EYIVTQYPSAETMEDFWKMLWEHNSTTIVTL
 |...|.  ..  |||  ...| |.||| .             . . | ||||..|.      . .    || || |  .|..||.|.. . . . |..|
nDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnD.YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

TDDQK---EDEPIYWPT-NVDE-PLTLGA--LTITLWKRNTLISPSSQGKFL-----GQSSQGTHTPLVIQNKeFDDDDQLNVRQYHCSYWPDCcSPLHT
|.|.    |   .||.  ..|.  . | .    |.  .  .| |   ....       .  .  .   ... .     | . | | .   |.|  | |  
tsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltait.laasdPyvvyqlqvknWkDl.sllln

AFDLIYAVQKRNEFLER------SNKETVGPITVHDRSGGCQAGTFCALSTLHQEM-IH
  ... |.. .|....       ....   || ||  .|  ..||...|  | ... | 
PesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeil
0040439 (Phosphotyrosine protein) phosphatases II 958-1213 6.1e-48 159.0 In-house 2-242 (249) alignment 
Range on Protein: 958-1213
Range on HMM: 2-242/249.0
DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQ---KEDEPIYWP
.|....   .|.||| .| .| ..||| .| .||   ..|||||.. ||......|.||.|  ||.||||.||||...|.||.||...   .|.   |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TnvDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKefDDDDQLNVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNEFLersN-Ket
.  ...|. | .|.||.. ..             ..  |.. | ..|.   |.. . |.....  |||   |  . ...|.| ||.| .| |   . .  
l..ggsleygdftvtllsvev.............kddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...pkg..

vGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 ||. ||   |   .|||.|. .... . .|  ||.. .|||.  .||. ... | |..| .||
.gpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
subfamily_PTPRA_pd Subfamily PTPRA 958-1227 1.4e-47 157.2 In-house 49-308 (330) alignment 
Range on Protein: 958-1227
Range on HMM: 49-308/330.0
DYEFSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWP
 .| ..  . |.||| ....| . ||| .| . ||.   ||||||..||......| .| | .||.||||.|.||..|.||| ||. .. .|     |||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

TnvDEPLTLGALTITLWKRNTLISpSSQGKFLGQsSQGTHTplviqnkefDDDDQLNVRQYHCSYWPDCCSPLHT--AFDLIYAVQKRneflersNKETV
.  .  .| | ..... . . |..  .  ||| |  .. .|         .....  |||.|   |||   | ..   ..|. .|.|        |. . 
d..eGlvtyGnirvevedetvlvd.ytvrkflvq.qlpdat.........rekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl.......nqqsa

GPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC---HSAELQIRSLR
|||.||  .|  ..|||..|... . .  |. ||....||   ..||... . | | ...|.|.       .||.. || 
gpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssle
subfamily_PTPN1_pd Subfamily PTPN1 958-1202 2.3e-23 77.4 In-house 21-256 (290) alignment 
Range on Protein: 958-1202
Range on HMM: 21-256/290.0
DYEF--SKARQSKHKNRDMDLIPVERSRVPISGVPGvdGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWP
|..   .|  . . .||  |. | . ||. .        |||||...  . . .||.|| | ..|.. ||.|.||..| ..| |    . ..     |||
dfptreaklpenrnlnryrdvspydhsrikleradn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

TNVD-EPLTLGALTITLwkrnTLISPSSQGKFLGQSSQGTHtplviqnkeFDDDDQLNVRQYHCSYWPDCCSPLHTAFDLIYAVQKRNEfleRSNKETVG
.. . . |.|   ....    .|||  .. ..  .  . .             ..  .. ..|   |||   |   |  | .  . |.     | .. ||
qgeeekellledtklkv....kliseerksyytvrllelen.........lktqetreilhfhyttwpdfgvpespaaflkflfkvres...GslssdvG

PITVHDRSGGCQAGTFCALSTLHQEMIHEE---AVDIYKTVKLYAAKRPNLITS
|  .|  .|  ..|||| . |.  .. ...   .||| |..      |  ||  
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 958-1185 6e-10 33.0 In-house 39-302 (349) alignment 
Range on Protein: 958-1185
Range on HMM: 39-302/349.0
DYEFSKARQSKHKNRDMDLIPVERSRVPISGV----------------PGVDGYINASFLQGYR--RQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTL
|...|.  ..  |||  |..| | ||| .                     .| |||| .|.  |   .. || || |.  |..||.|..   .   .. |
dvilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL

TDDQKED---EPIYWPTNVDEpltlgALTITLwKRNTLISPSSQGKFLGQSSQGTHTPL---VIQN---KEFDDDDQLNVRQ--------YHCSYWPDCc
.||....     |||     .       |. | .   | . . ||  |  | .    .    . .|    . ||||.... .             |.|  
nddkelslekcdiywqelsys.....nitvkl.qnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldl.

SPLHTAFDLIYAVQKRNEFLERSNK------ETVGPITVHDRSGGCQAGTFCALSTLHQ--EMIHEEAVDI
| |     .. |.. .|....  .       . . .. ||  .|  ..|... |  | .  |. ..| . |
slllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnki
subfamily_PTPRK_pd Subfamily PTPRK 959-1223 2.9e-41 136.3 In-house 35-284 (314) alignment 
Range on Protein: 959-1223
Range on HMM: 35-284/314.0
YEFSKARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKED---EPIYWPT
.. .|  . ..||| .|... .|||| .  . |     ||||... .|.| ...||||.|  ||..|||......|...|| ||. ...       ||| 
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

NVDEpltLGALTITLWKRNTLISPSSQGKFLGQssqgthtplviqnKEFDDDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVQKrnefLERSNKETVGPI
. .     | . ..| . ..|    ..   . .              .   ...  |||..   |||   | .    |.  |..    .. |..|. |.|
dtev...ygdikvelvetellaelvvrifrvek.............largqeeirevrqfqflgWpdhdvPvsat.gllklvrr....vkksqeeeaGri

TVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA-LQSCHSAELQI
 ||  .|. ..|||.|.... . . .|. ||....||   ....|..   | | ... . |..|   |  |
vvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetai
0042113 (Phosphotyrosine protein) phosphatases II 960-1214 1.7e-46 154.0 In-house 2-240 (245) alignment 
Range on Protein: 960-1214
Range on HMM: 2-240/245.0
EFSKARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTn
....   .|.||| .| .| ...|| .| ..|   ..|||||.  |||. . .|.||.|..|| ||||.||||...||||.||..     .. . |||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

vDEPLTLGALTITLWKRNTlispssqgkflgqSSQGTHTPLVIQNKefDDDDQLNVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNEFlersN-KetvG
 .|.|| | .|.||.. ..              .  |.. | ..|.   || ...|..||.  ||| . |  | . .|.. .|.|  .     . .   |
.gesltygdftvtllseeh.............lddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalae....dsn...g

PITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
|. || . |   .|||.|. .... . .|  |.....|| .  .||. ... . |..| .||.
pvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 960-1216 5.5e-28 92.9 In-house 34-275 (281) alignment 
Range on Protein: 960-1216
Range on HMM: 34-275/281.0
EFSKARQSKHKNRDMDLIPVERSRVPIS--GVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTN
. ||| . ..||| ....  . .|| ..         ||||.|..||. ..|||.|| |  .....||.|.||.. ..|| .| . ...      ||| .
taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

VdEpltlgaltitlwkrnTLISPSSQGKFLGQSSQGTHTPLVIQNkEFDDDDQLNVRQYHCSYWPDCCSPLHTAfDLIyavQKRNEFLERSNKETVGPIT
  .               .|.    . |.. .... |.   ...  | .. .. .|.| .   |||   |  |. .|.   . |.| |. ..|.|  |. 
n.s...............elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattk.ell...efrkevlkltekktkaplv

VHDRSGGCQAGTFCALSTLHQEMIHE-EAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSC
.|  .|  ..||. || .| ... .| | .|.  .|.    .|  .. .   | ...||.   
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 960-1054 9.2e-14 45.7 In-house 37-130 (347) alignment 
Range on Protein: 960-1054
Range on HMM: 37-130/347.0
EFSKARQSKHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKeDEPIYWPTN
. || |  ..|  |   . .   .   |    |..||||| ..    ..|||.||||  .|. |||||.   . | .||. . .| || |   .|
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepik.deaieefan
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 960-1195 3.4e-11 37.3 In-house 45-268 (310) alignment 
Range on Protein: 960-1195
Range on HMM: 45-268/310.0
EFSKARQSKHKNRDMDLIPVERSRVPISG-VPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEPI---YWPTnV
 .   ..  ||||  |..  . ||| .       . || | ...    .. .|..| |   |. |||.|...  . .|. |    .|  |    |||. .
tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.l

DEPLTLGALtitlwkRNTLISPSSQGkFLGQSSQGTHTPLVIQNKE-FDDDDQLNVRQYHCSYWPDCCSPLHTAfdliYAVQKRneFLErsnKETVGPIT
    | | .      | | .| ||.  |       |  |  .   |   . ..| |   .   |||.  |        ..| .|  .|    .   ||  
gvtetygci......rvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc....htvpqr..lla...qvrhgpcv

VHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAK
||  .|  . .. .||    . . . . ||. . .  .  .
vhcsagkdrlyvvvalklkidkldrglkvdaeevktellks
0037934 (Phosphotyrosine protein) phosphatases II 961-1214 4.7e-42 139.6 In-house 4-239 (243) alignment 
Range on Protein: 961-1214
Range on HMM: 4-239/243.0
FSKARQSKHKNRDMDLIPVERSRVPIsgvPGvDGYINASFLQGYRRqneYIVTQYPSAETMED----FWKMLWEHNSTTIVTLTDDQ---KEDEPIYWPt
...  ....||| .| .| ..||| .   .| ..||||.. ....|   .|.||.|  || ||    ||.||||...|.||.||...   .|. . ||| 
iallpenlsknrysdilpydhsrvkl...eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

nvDEPlTLGALTITLWKRNtlispssqgkflgQSSQGTHTPLVIQNkeFD-DDDQLNVRQYHCSYWPDCCSPLHtAFDLIYAVQKRNEFLER-----SNK
  .|  | | .|.||.. .             . .. |.. |...|   | || ...|..||.  ||| . | .   ||.  ... .||.|.      ..
..gev.tygdftvtllsee.............hlddytvrtlllen..ldlddltrlvihyhylpwpdhgvPds.pedlldfldevrefieellsllald

-EtvGPITVHDRSGGCQAGTFCALSTLHQEMiheeAVDIYKTVKLYAAKRPN-LITSREDYYYLFKALQ
 .  ||. || . |   .||..|. .... .     ||....|||. ..||.  ..... |..| .||.
sg..gpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPN12_pd Subfamily PTPN12 961-1223 5.2e-34 112.4 In-house 34-283 (290) alignment 
Range on Protein: 961-1223
Range on HMM: 34-283/290.0
FSKARQSKHKNRDMDLIPVERSRVPISGVPGVD--GYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTNV
 ... . ..|||  |..| . ||| .|   ...  .||||.|..|   . ||| .| | ..|..|||.|.||.| . .| .    . .|     ||| ..
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

DEPLTLGALTITLWKRNTLispsSQGkFLGQSsqgthtpLVIQNKefddDDQLNVRQYHCSYWPDCCSPLHT--AFDLIYAVQKRNEflersnkETVGPI
.|.|. |....|| . ...    ... || ..       | ....    ... .|.|.|   |||   |  .   ..|| .|....|       .   |.
eeelefgefevtleeekav....ddd.flirt.......Lkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.......sedaPl

TVHDRSGGCQAGTFCALSTLHQEMIHEEA---VDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCHSAELQI
 ||  .|  ..|| .|.   .. . .|     .|... |     .|. |. ..| | ...||. .  ..||.|
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei
0049772 (Phosphotyrosine protein) phosphatases II 961-1214 1.1e-23 79.9 In-house 40-277 (314) alignment 
Range on Protein: 961-1214
Range on HMM: 40-277/314.0
FSKARQSKHKNRDMDLIPVErSRVPISGVPGVD-GYINASFLQGYrrqNEYIVTQYPSAETMEDF----------WKML--WEHNSTTIVT---------
...    ..||| .| .|.. .|| ..|.|. . .|||||.. |.   . .|.||.|. .|..||          |.|   ...|. .||          
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LTDDQKEDepiywptNVDEPLTLGALTitlwkrntlispssqgkflgqssqgthtplviqnKEF--DDDDQLNVRQYHCSYWPDCCSP
            |..            |   . .|  |                                   .|   ... . .. .|..  .|| . |
lsrLdaAlgKtpllildgng.......neptaadlellk..................................eelydpelferlgikylripvpDgsap

LHTAFDLIYavqkrnEFLERSnkETVGPITVHDRSGGCQAGTFCALSTLHQEMiheeAVDIYKTVKLYAAKRP-----NLITSREDYYYLFKALQ
|   || ..      ||.|.   .. ||. || ..|   .|||...  |   .     |.. .... . .|||     ..| . |.|.. ..||.
lledfdefl......efieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefileall
subfamily_egg_pd Subfamily egg 961-1074 8.1e-14 46.0 In-house 41-152 (307) alignment 
Range on Protein: 961-1074
Range on HMM: 41-152/307.0
FSKARQSKHKNRDMDLIPVERSRVPISGvpgvdGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK-EDEPIYWPTNVDEPL
  |||. . . .|.  . .|  |   ..      .| |  ..|    ||.|..| |  .|..|||.|... .   || ||  .. |  . |||   ...|
lekarskrvhckdssrvklelrrGqyld.....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdsl

TL--GALTITLWKRNTL
 .  |.| |.  | .  
vtvpGslrienlkvdsk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 961-1042 7.3e-08 26.2 In-house 24-110 (332) alignment 
Range on Protein: 961-1042
Range on HMM: 24-110/332.0
FSKARQSKHKNRDM----DLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETME-DFWKMLWEHNSTTIVTLTDD
. .. .   .| ||     |  ...||| ..   | | . |||...|| ... ||..| |  .  |  ||.|. |.. . |. . | 
ypntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdi
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 962-1215 6.5e-41 135.2 In-house 4-240 (250) alignment 
Range on Protein: 962-1215
Range on HMM: 4-240/250.0
SKARQSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKED--EPIYWPTnvDE
.|  | |.|||..|.|... ||| .  . |     |||||||.||. .. .|.|| |  .|.||||.|..|..|.||| ||. . ..   . |||.  ..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPv..ek

PLTLGALTITLWKRNTlispssQGKFlgqssqgTHTPLVIQNKEfdDDDQLNVRQYHCSYWPDCCSPLHTA--FDLIYAVQkrnefleRSNKE-TVGPIT
. . | .|..| ....       . .       |.. |.. ...    |.  |||.|   ||| . | ..   ..|.  ||       .|...   .|. 
aekyGdvtvsllskee......fady.......tkrklklskak..kaderivrqlhfvvWPdkgvPevatavLellkkvq.......asqqqagnaPvi

VHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQS
|.  .|  ..|.|.|.... . . .|. ||..| .|   ..||. ..|.| | ....... 
vqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 962-1214 2.4e-35 117.0 In-house 44-276 (315) alignment 
Range on Protein: 962-1214
Range on HMM: 44-276/315.0
SKARQSKHKNRDMDLIPVERSRV--PISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPtnvD
.|  . |.||| .. |. ..|||  |.  .     |.||.|..|| ... || .| | .....|||....|.. ..|| ||.  ....     |||   |
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp...d

EPLTLGALTITLWKRNTLISPSSQgKFlgqssqgthtplviqNKEFDdDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVQKrnefLERSNKETVGPITVH
. .. | .|.|. . .     . .  .                  |. |.  .| |.| . |||   | .|   |.  ...      . ....||.| ||
kkviyGkitvtrkseevnteytvr.tl...............svvfg.dnirevvqlhytswpdmgvpkyti.plmnlirt....vkqhhtnsvgaivvh

DRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
 ..|  ..|||..|... ...  |.|.|.|. ..   ..| ... . | | ....|| 
csaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 962-1132 1.2e-21 71.6 In-house 40-156 (392) alignment 
Range on Protein: 962-1132
Range on HMM: 40-156/392.0
SKARQSKHKNRDMDLIPVERSRVPI---SGVPGVDgYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDepiywptnvdep
..    ..|||  . .| ...|| .     .|  | |.|||.....  .. || .| | | ...|||.|....| |||. .|. .. |            
aqkeinlkknryknilpydsarvkleviddipdsd.ylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

ltlgaltitlwkrntlispssqgkflgqssqgthtplviqnkefDDDDQLNVRQYHCSYWPDCCSPLHTAFDLI
                                              ||.  | |.| . |||   | ||.  | 
............................................kgddartvaqfhftewPdkdvpkhtssllk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 962-1212 6.1e-17 56.6 In-house 3-236 (239) alignment 
Range on Protein: 962-1212
Range on HMM: 3-236/239.0
SKARQSKHKNRDMDLIPVERSRVPIS---GVPGVDgYINASFLQGYRRQ-NEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTN
.| |  | |||  ...  ..||| .      |  | |||||.|. |    . || ||   . .  |||.|.|.     || ||   . .|.    ||| .
akkrvnkaknryanivtydhsrvvleklsndphsd.yinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

VDEpltLGALTITLWKRNTLISPSSQGKFLGQSSQgthTplviqnkefdddDQLNVRQYHCSYWPDCCSPLHTAFDLiyAVqkRNEfLERSNKETVGPIT
  .      | .|| | . .     .   . |  |   |            ..  | ||| . |||   | ...  |   .  | . . . .     |  
tsk...ycnlrvtlrktevfadyiirtfvmsqvgq...t............eeryvyqyhftvwpdkgvpqyatavl..gl..rrk.itkdslpgarpwv

VHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA
.|  .|  ..|.|  . .. ..  ....|||.. ||     || .. . |.| ... |
ihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 963-1214 6.7e-34 112.1 In-house 40-274 (315) alignment 
Range on Protein: 963-1214
Range on HMM: 40-274/315.0
KARQSKHKNRDMDLIPVERSRVPI---SGVPGVDgYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTNVD
. ..  .|||  . .|....|| .      |  | |||||.....  .. || .| |   ...|||.|..... |||| .|. |..|      ||| .  
retinfkknryknilPldsarvkleviddsPdsd.yinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrka

EPLTLGALTITLwkrntlISPSSqgkflgqSSQGTHTPLVIQNKefddDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVQKrnefLERSNKETVGPITVH
.   .|.. ..|      .| ..        ..|..  ||...     ... .| |..   |||  .. .|.  |.  ...    .  .|..   .. ||
dsvefGsikvel......lslea.......dtdgvarklvtrks....eesrtvtqfqftewPdkGvdkqts.sllklike....vkadngkkefsllvh

DRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
  .|  ..| ....    ... ....||....||   |||| |. ..|.| ... |..
csaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 963-1212 9.2e-17 56.0 In-house 3-235 (239) alignment 
Range on Protein: 963-1212
Range on HMM: 3-235/239.0
KARQSKHKNRDMDLIPVERSRVPIS---GVPGVDgYINASFLQGYRRQ-NEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTNV
| |  | |||  ...  ..||| .      |  | |||||.|. |    . || ||   . .  |||.|.|.     || ||   . .|.    ||| . 
kkrvnkaknryanivtydhsrvvleklsndphsd.yinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

DEpltLGALTITLWKRNTLISPSSQGKFLGQSSQgthTplviqnkefdddDQLNVRQYHCSYWPDCCSPLHTAFDLiyAVqkRNEfLERSNKETVGPITV
 .      | .|| | . .     .   . |  |   |            ..  | ||| . |||   | ...  |   .  | . . . .     |  .
sk...ycnlrvtlrktevfadyiirtfvmsqvgq...t............eeryvyqyhftvwpdkgvpqyatavl..gl..rrk.itkdslpgarpwvi

HDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA
|  .|  ..|.|  . .. ..  ....|||.. ||     || .. . |.| ... |
hcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 963-1042 7.7e-08 26.3 In-house 43-117 (303) alignment 
Range on Protein: 963-1042
Range on HMM: 43-117/303.0
KARQSKHKNRDMDLIPVERSRVPISGvpgvDGYINASFLQgYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDD
.  .  .||| .|.| .. |.| .|       || ||.|.    ..  |.|| | . |  |||.|. | .   .. |  |
qfvknmdknrfvdvicldhskvklsd....ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 964-1217 4.5e-31 103.1 In-house 48-284 (297) alignment 
Range on Protein: 964-1217
Range on HMM: 48-284/297.0
ARQSKHKNRDMDLIPVERSRVPISGVPGV--DGYINASFLQGYRRqnEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEP--IYWPTNVDEPl
 .   .|.|  . .|...||| .  |       |.||||..|..   ..| || |  .|..|||.|..... .||| |.||...|.    ||. .   . 
kkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt.

tLGALTITLwkrntlISPSsqgKFLGqssqGTHTPLVIQNKefDDDDQLNVRQYHCSYWPDCCSPL-HTAFDLIYAVQkrnEFLERSNKETVGPITVHDR
 .| ....|       | |   .  |    . .  |....   .   .  |.||.  .|||   .  ..|  |.  ..   |  .  .... ||. ||  
.fGdvsvvl......lsvs...ereG....fikrelevtkg..kakarrvvkqyqfveWPdkaverkdsassllklis...evrkdfsqnaegPllvhcl

SGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCH
.|  ..| ....     |. .|..|||...||    .||.|.  .|.| ....|.    
aGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 964-1070 4.1e-18 59.9 In-house 93-197 (244) alignment 
Range on Protein: 964-1070
Range on HMM: 93-197/244.0
ARQSKHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEpiYWPTNvdEPLTL--
  .. .|||.   .|.. .|||.|     . ||||||.    |  |||.||.| |.|  |||||. |     .| |   ..|||  |||    |||    
npnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede..ywpds..eplewye

GALTITLWK
  .|.||  
editvtltd
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 966-1220 7.4e-30 98.7 In-house 37-280 (287) alignment 
Range on Protein: 966-1220
Range on HMM: 37-280/287.0
QSKHKNRDMDLIPVERSRVPISGVP--GVDgYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEP---IYWPTNvDEPLT
 . .|||  |..|.. .|| .|  .  |.| |||| .. .|......|..| | | |. |||....|..|....|.| . .|       ||| . . |. 
aavkknryadvlPiddtrvllsaegelGsd.yinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

LGALTITLWKRNTlISPSsQgkflgqssqGTHTPLVIQnkeFDDDDQLNVRQYHCSYWPDCCSPlHTAFDLIYAVQKRNEFL--ERSNkETVGPITVHDR
.|  ...| ...   .|            |. .  .|.    .  .   |.|..   |||   .  ||  ||  | . ....  .|.  . |||. ||| 
vGGysvvlldydi.kePe.y.........gvralrlid...letrearvvkqldllswPdkvla.Ptavglirfvldvkqhielarda.sevGPlvvhdd

SGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQSCHSAE
 |  ..|.. |. .| . .     ||. ..|     .|  |. .   . .|..|| . . ..
vGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_CG42327_pd Subfamily CG42327 966-1071 5.8e-15 49.8 In-house 27-140 (319) alignment 
Range on Protein: 966-1071
Range on HMM: 27-140/319.0
QSKHKNRDMDLIPVERSRVPISGVPG--VDGYINASFLQGYRR-QNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKED---EPIYWPTNVDE--
 || |.| .. .|.  .||    ..    | |..||...||.  .| || .| .  ..  |||...|| .| .||.||| ..      . |.||.     
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

PLTLGALTITLWKR
  . | . .|| .|
tslyGdilvtlkgr
0041856 (Phosphotyrosine protein) phosphatases II 967-1213 4.2e-33 109.9 In-house 1-167 (182) alignment 
Range on Protein: 967-1213
Range on HMM: 1-167/182.0
SKHKNRDMDLIPVERSRvpisgvpgVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTddqkedEPIYWPtnvdepltlgalti
...||| .| .|...||        .  ||||... |.......|.|| |  .|..||..||.|.. ||||.||      |. |||              
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp..............

tlwkrntlispssqgkflgqssqgthtplviqnkefdDDDQLNVRQYHCSYWPDCCSPLhtafdliyaVQKRNEFLERSNKeTVGPITVHDRSGGCQAGT
                                     .. . .. ||..  ||| . |          ... ..|.|. ..   ||. || . |   .||
.....................................ellerlgiqylylpwpDhgvpd.........ldelldfieevle.eggpvlVHCsaGvgRtgt

FCALStlhqeMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
..|.      ....  |.....|||.  .||. ... . |..|  ||
lvaay.....lmkklgvsleeavklvrsrRpgmvitpnqyfflqlal
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 967-1212 1.5e-24 81.5 In-house 3-234 (237) alignment 
Range on Protein: 967-1212
Range on HMM: 3-234/237.0
SKHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRR-QNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD---DQKEDEPIYWPtNVDEPLTLG
.| |||  ...  . ||| . |  .   ||||..|.|.    ..|| .| |   . .|||.|.|. . . || ||     ...    ||| . |.| . |
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaayg

ALTITLWKRNTLISPSSQgKFLgQSSQGTHTplviqnkefdddDQLNVRQYHCSYWPDCCSPLHTAFDLIYavqkRNEFLERSNK-ETVGPITVHDRSGG
 ||..| |.. .   . .  .|  | ..|              .   . ||. . |||   | .||  | .    | . ..||..    ||  .|  .| 
vltvslkkkeefsdytvr.sll.lskrltlk............evrlihqyqftswpdrgvpqqtaallrf....rkniinrsphvsesgpwiihcsagv

CQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA
 ..| |  . .. ..   .. ||||. |.     || .| ....| .....
grtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 967-1213 4.9e-17 56.5 In-house 56-279 (290) alignment 
Range on Protein: 967-1213
Range on HMM: 56-279/290.0
SKHKNRDMDLIPVERSRVPISG-VPGvdGYINASFLQGYRrqNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTNVDEPLTLG
  .|||  |..  ...|| ..   .|   |. | ...| .    .|.|| . ..|. |.|.|. ... ..|| |    .| |     |.| .  | ||.|
efkknrykdvvcndktrvilkdGydG..dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

ALTITLWKRNTlispssqgkflgQSSQGTHTPLVIQNKEFDDDDqlNVRQYHCSYWPDCCSPLHTafdliYAVQKRNefleRSNKETVGPITVHDRSGGC
..|..  . ..            . ..  .  | ...|.   .    .. ..   ||| . .| |      |. .      |. ... ||..||  .|  
eitvlcseedd............kdaniikktlsvrdkdsGkeh..klkhlkikswpdksvalst.....lallrtl....rilrkasGpvvvhcsaGiG

QAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
..||| |. .  | ...  ..|. ..|.     | | .    .|  | ..|
rtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 967-1214 1.5e-11 38.8 In-house 35-267 (285) alignment 
Range on Protein: 967-1214
Range on HMM: 35-267/285.0
SKHKNRDMDLIPVERSRVPISGVpgVDGYINASFLQG-YRRQNEYIVTQYPSAETMEDFWKMLWEHNSTT---IVTLTDDQKEDEPIYWPTNVDEPLTLG
    ||  |.  .| .|| .        || ||...   . |. || || |  ||. |||.|... . .    ..|| .   |   .|.| .. | . .|
npdlnryadvrcieetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfg

ALTITLWKRNTlisPSSQGKflgqssqgTHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCSPLHtAFDLIYAVqKrneFLERSN-KETvgPITVHDRSGG
   ||| . .     .  |             | . | |    . | . . .  .|||  .|   |  .|    |   .... | ||.  || ||  .| 
kyeitltecke...eaiagt........ilnaltvintedasseplymnhvqvpwwpdqlaped.arpmiely.k...wvkkvnpkek..picvhcsagv

CQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
 .. ||  .      .. .  ...   |.   | | . . |. .. .|.  | 
grtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlm
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 967-1213 1.1e-08 29.5 In-house 43-267 (288) alignment 
Range on Protein: 967-1213
Range on HMM: 43-267/288.0
SKHKNRDMDLIPVERSRVPISgvPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTNVDEPLTLGA
.  ..|  .|   . .|| .|     | ||.|  .   . ..  | .| |   |.| .|||| | .   || |.   .  ||    |.|... |   .| 
nptrdryenlprcditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

LtitlwkrntlispSSQGKFLGQSSQGTHTPLVIQNKEFDDDDQlNVRQYHCSYWPDCCSPlhTAFDLIYAVQKRNeflersnKETVGPITVHDRSGGCQ
|              .. |   .  . . .  ......  .. .  |.. |   |.| . |    .     . ..        |..  || || . |  .
l.............ctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvP..enylsplrllevl.......kslqkPivvhssaGvGr

AGTFcALSTLHQEM-IHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
.||. .|. .  |.   .. . | . ..   ..| . |..   | |... .
tgtl.ililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 967-1209 6e-08 26.7 In-house 55-281 (305) alignment 
Range on Protein: 967-1209
Range on HMM: 55-281/305.0
SKHKNRDMDLIPVERSRVPISGVPgVDGYINASFLQGY-RRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTD---DQKEDEPIYWPTNVDEPLTLg
.. |||  |.   ..| | ..  .    || | ..      .. .|..| |  .|...|| |. ...   || |       |     |||.   | |.| 
aitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel.

altitlwKRNTLISPSSQGKFLGQSSQGTHTplvIQNKEFDDDDQLNVRQYHCSYWPDCCSPL--HTAFDLIYAVqkrnefleRSNKetvGPITVHDRSG
       |   ..   |  | . . ..   |   . |  .  |... ||. . . |||   |    |...|. |.        |  |    || ||  .|
.......ksgivvenvsgskpmerdaeiqit...llnltysgdqkmsvrhlqwtewpdrgvppckltslellsai........rgsk...vpivvhcsag

GCQAGTFCALSTLHQEMIHEE-AVDIYKTVKLYAAKRPNLITSREDYYYL
  ..||  |.  . ...  .  .  . . ||    .|   | .  .| ..
igrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfi
Y_phosphatase Protein-tyrosine phosphatase 968-1214 6.4e-50 165.1 Pfam-A 2-234 (235) alignment 
Range on Protein: 968-1214
Range on HMM: 2-234/235.0
KHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTNVDEPLTLGAL
|.|||  | .| ...|| ..| .|   ||||....||......|.|| |  .|.||||.|.|......||.||....   |  . |||.. .|.|| | .
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TITLWkrntlispssqGKFLGQSSQGTHTPLVIQN----KefdddDQLNVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNeflersnKETVGPITVHDR
...|             |   .... | . | ...    .     ..  |.|.|.  ||| . |   .  .||| .|.|..       ... ||..||  
kvelk...........ekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkveksk.......eaksgpvvVhCs

SGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
 |  ..|||.||..| ... .|| ||....||   ..||....| | |..| ||..
aGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 968-1214 6.4e-50 165.1 In-house 2-234 (235) alignment 
Range on Protein: 968-1214
Range on HMM: 2-234/235.0
KHKNRDMDLIPVERSRVPISGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTNVDEPLTLGAL
|.|||  | .| ...|| ..| .|   ||||....||......|.|| |  .|.||||.|.|......||.||....   |  . |||.. .|.|| | .
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TITLWkrntlispssqGKFLGQSSQGTHTPLVIQN----KefdddDQLNVRQYHCSYWPDCCSP--LHTAFDLIYAVQKRNeflersnKETVGPITVHDR
...|             |   .... | . | ...    .     ..  |.|.|.  ||| . |   .  .||| .|.|..       ... ||..||  
kvelk...........ekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkveksk.......eaksgpvvVhCs

SGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKALQ
 |  ..|||.||..| ... .|| ||....||   ..||....| | |..| ||..
aGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 968-1057 4.6e-10 33.6 In-house 38-133 (281) alignment 
Range on Protein: 968-1057
Range on HMM: 38-133/281.0
KHKNRDMDLIPVERSRVPISG-VPGV--DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLT---DDQKEDEPIYWPTNVDE
..||| ...  .. ||| .   .|      || | ...    .  ||.|| |  ||  |||.|.|. |.|.|| |    . ..|    |.| |   
nkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 969-1213 1e-29 98.1 In-house 45-272 (515) alignment 
Range on Protein: 969-1213
Range on HMM: 45-272/515.0
HKNRDMDLIPVERSRVPI---SGVPGVDgYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEP---IYWPTNVDEPLTLG
.|||  . .| ...|| .      |  | |.|||.....  .. || .| |   ...|||......| |||. .|. ...|      |||    . . .|
kknryknilPydsvrvklevindnPhsd.yfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG

ALTITlwkrntLISPSSQGKflgqssqGTHTPL-VIQNkefddDDQLNVRQYHCSYWPDCCSPLHTAfDLIYAVQkrnEFLERSNKETvGPITVHDRSGG
 . .       |.| .. .        |.   | |...     ||   | |.|   |||  .| ||   |.  ..   |     .. |  |. .|  .| 
sikve......lvsleactg.......gikrkltvlkg.....ddsrtvtqfhfteWPdkGvpkhts.sllklik...evkadhgqyt.hpliihcsaGv

CQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
 ..| ....     ..   ..||....|.   .||| |.  .|.| ... |.
GrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_eak_pd Subfamily eak 969-1067 2.4e-10 34.3 In-house 54-155 (332) alignment 
Range on Protein: 969-1067
Range on HMM: 54-155/332.0
HKNrDMDLIPVERSRVPI-SGVPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTNVDEPLTLGAL
..|  ....| .|  | . |     .|||||| ..     ..||.|  .| . .  ||.|. | .| .|| | .| .   |    |.| .  | |  | |
nrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

TIT
 ..
dve
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 980-1209 3.4e-07 24.7 In-house 31-251 (290) alignment 
Range on Protein: 980-1209
Range on HMM: 31-251/290.0
ERSRVPISG--VPGVDGYINASFLQgYRRQNEYIVTQYPSAET-------MEDFWKMLWEHNSTTIVTLTDDQKEDEP-------IYWPTNVDEPLTLGA
| .||.. |     .|.|| |.... .    . |.|| | ...       .|.|| |  . ... .| | . .....         | |..|.| |... 
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

LTITLwkrntlispssqgKFLGQSSQGTHTPLVIQnkeFDDDDQLNVRQYHCSYWPDCCSPLHTaFDLIYAVQKrnefLErsNKETvgPITVHDRSGGCQ
||.               |   .  .  .  ||..   |||. .. |  .  . | ..  . .|   |. ..||    ..  ...|  |. ||.  |  .
ltvkC.............kskekeddvetRelvvk...fddeeeftvtHsllkgWnklnvqedt.ktllsliqk....vk..askt..pvivHcvdGiSr

AGTFCALSTLHQEMI-HEEAVDIYKTVKLYAAKRPNLITSREDYYYL
  .. |.    | ..  ...| . . .|    .| ..||| ... . 
sAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafv
0044763 (Phosphotyrosine protein) phosphatases II 981-1215 4.2e-19 64.3 In-house 4-169 (178) alignment 
Range on Protein: 981-1215
Range on HMM: 4-169/178.0
RSRVPISGVPGVDG--YINASFLQGYrrqneYIVTQYPSaetmEDFWKMLWEHNSTTIVTLTDDQK---EDEPIYWPTNVDepltlgaltitlwkrntli
|.|| .| ..|. .  |||||.  ..     ......|.    .|....|.|.. |.||.||...    .... |||.. .                   
rtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

spssqgkflgqssqgthtplviqnkefddddqlnvRQYHCSYWPDCCSPlhtafDLIYAVQKRNEFLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQ
                                    ||..  .|| . |     ||.  ...  ||.|.  .|  ||. || . |   .||..|.  ...
...................................iqylhipipDhgvp.....dllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkk

EmiheeAVDIYKTVKLYAAKRPnLITSREDYYYLFKALQS
       ..... ..|. ..||  .........| .  . 
l.....glsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 985-1071 5.7e-11 36.8 In-house 11-89 (130) alignment 
Range on Protein: 985-1071
Range on HMM: 11-89/130.0
PisgvpgVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEpiYWPTNvdEPLT--LGALTITLWKR
.       . ||||||.    | .||. || | |.|  |||||. |     .| |   ..|||  |||    |||      ...|| .|
q......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede..ywpds..ePlewyeediivtltdr
0046846 (Phosphotyrosine protein) phosphatases II 986-1213 1.5e-22 75.7 In-house 5-169 (176) alignment 
Range on Protein: 986-1213
Range on HMM: 5-169/176.0
ISGVPGVDGYINASFLQGYRrqneYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTNVDEPLtlgaltitlwkrntlispssqgk
..| ..   ||||... |.|    .|.||.|  .|..||..||.|.. |..|.||...  .    | |||   .. .                       
llgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

flgqssqgthtplviqnkefddddqlnvrQYHCSYWPDCCSPLHtaFDLIYAVQKRNEFLERSnketvGPITVHDRSGGCQAGTFCALStlhqEMIHEEA
                             ||..  ||| . | .   .|. ...  .|.|..      ||. || . |   .||..|.      ...|  
.............................qylhlpwpDhgvpdl..elllellefirealkeg.....gpvlVHCsaGigRtgtlvaay....llelekg

VDIYKTVKLYAAKRP-NLITSREDYYYLFKAL
........|. ..|| . ....| |..| ...
lsveealalvreqRplgavqtpeQyrflyefe
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 989-1209 5.6e-10 33.4 In-house 71-273 (301) alignment 
Range on Protein: 989-1209
Range on HMM: 71-273/301.0
VPGVDGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDD---QKEDEPIYWPTNVDEPLTLGALTITLWKRNTLISPSSQGKFLg
| |    | | ...   . . .|.|| |  .|.|||| ||  ..  .|| |.     ..|    | |... | | .|  .|.. ....... . . . | 
vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtl.

qssqgthtPLVIQNKEFDDDdqlNVRQYHCSYWPDCCSPLHT--AFDLIyavqkrnEFLERSNKetvgPITVHDRSGGCQAGTFCALSTLHQEMIHEEAV
         ..   ..|.      |  |  | |.|   |      |||.       |.. .|.|    || ||  .|  .. .| .   | .|.  .  .
........evedstgkfatr...tvthyqysewtdrgvPkshaelfdlm.......elvkksek....PivvhcsaGiGrsvafigteylareveadpti

DIYKTVKLYAAKRPNLITSREDYYYL
.. ...|    .| | .  ..  |..
eltealkhlrehrwngvqtnsqlywm
0051429 (Phosphotyrosine protein) phosphatases II 992-1215 2.7e-24 81.7 In-house 3-223 (272) alignment 
Range on Protein: 992-1215
Range on HMM: 3-223/272.0
VDGYINASFLQGYRR---QNEYIVTQYPSAETMEDFWKMlWEHNSTTIVTLTDDQ---KEDEPIYWP----------TNVDEPLTLGALTITLWKRNTLI
..|||||... || |    . .. ...|.  | .|||.. .|.. .|||.|...    ... . |||           ..... ..|||..||..  .| 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

SpssqgkflgqssqgTHTPLVIQNKEFDDDDQLNVRQYHCSYWPDCCSPLHTAFDLIYAVQKrneflersnketVGPITVHDRSGGCQAGTFCALSTLHQ
               ..    .  .... .. . |...|.  ||| . | ..  .|. ....             ||. || ..|    ||..||  | .
d..............yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld............ggpvlvHCsaGkdRTGtvvallllll

EMIHEEAVD--------IYKTVKLYAAKRPNLITSREDYYYLFKALQS
 . .|  ||        ....|.   |.||. . . | |..|..||. 
gvsletivddYlltnlyleeaveelraqrpgavqteeqylflyealle
0043147 (Phosphotyrosine protein) phosphatases II 993-1210 1.2e-26 88.9 In-house 5-154 (172) alignment 
Range on Protein: 993-1210
Range on HMM: 5-154/172.0
DGYINASFLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDqkedepiywptnvdepltlgaltitlwkrntlispssqgkflgqssqgth
. |||||.| .|.  ...|.||.|  .|..|||.||.|.. |.||.||.                                                   
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

tplviqnKEFDDDDQLNVRQYHCSYWPDCCSPlhTAFDLIYAVQKRNEFLERSNKetvGPITVHDRSGGCQAGTFCALSTLHqemiheEAVDIYKTVKLY
           .. . .. ||.. .||| . |  ..  |. ...  .|.| .|..   ||. || . |   .||..|.  ..      . ......|.|.
.......lydpellerlgiqylylpwpDhgvp..llellleflefidellalspg...gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalv

AAKRPNLITSREDYYYLF
 .|||. ... . |..| 
rekRpgavqnpsqyrfly
0051082 (Phosphotyrosine protein) phosphatases II 993-1212 4.2e-19 64.1 In-house 3-148 (151) alignment 
Range on Protein: 993-1212
Range on HMM: 3-148/151.0
DGYINASFLQGYrrqneYIVTQYPsaetMEDFWKMLWEHNSTTIVTLTDDQ-KEDEPIYWPTNVdepltlgaltitlwkrntlispssqgkflgqssqgt
..|||.|.. |.     ......|    ..||...|.|.. .|||.|....  . .| |.| .                                     
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeergycpeylpelg....................................

htplviqnkefddddqLNVRQYHCSYWPDCCsplhtafdLIYAVQKRNEFLERSNKETVGPITVHDRSGGCQAGTFCALSTLHQEmiheeaVDIYKTVKL
                ..|.....  |||          |    .  .||||  ..   ||. || ..|    ||..||  ...       |....... 
................ievlhipildwpdpg........lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealee

YAAKRPNLITSREDYYYLFKA
| .|||..... . ......|
yrlkrpgvvqpnqqflfqlfa
0036282 (Phosphotyrosine protein) phosphatases II 994-1210 2.5e-27 91.1 In-house 3-163 (174) alignment 
Range on Protein: 994-1210
Range on HMM: 3-163/174.0
GYINASFLQGYRRQNEYIVTQYPSAetmedFWKMLWEHNSTTIVTLTDDQKED---EPIYWPTnvdepltlgaltitlwkrntlispssqgkflgqssqg
 |||||.| .... ...|..|.| |     ||.||.|...||.|.|.. .  .    . |||.                                     
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

thtplviqnkeFDDDDQLNVRQYHCSYWPDCCSPLHTAfdLIYAVQKRNEFLERsnkETVGPITVHDRSGGCQAGTFCALSTLHQEMIhEEAVDIYKTVK
           . .|   .. ||..  ||| . |  .   |. .|.  .|.|..      ||. || . |   .||..|.  ... .. | .||....|.
...........lredlerlgiqylylpwpDhgvpdlsi..llefvkfveealse...dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvr

LYAAKRPNLITSREDYYYLF
    .||. ... . |..| 
elRlqrpgmvqtpsQyrfly
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 994-1124 9.3e-06 18.7 In-house 56-155 (169) alignment 
Range on Protein: 994-1124
Range on HMM: 56-155/169.0
GYINAsflqgyrrqneyivtqypsaetmedfwKMLWEHNSTTIVTLTDDqkEDEPIYWPTNVDEPLTlGALTITLWKRNTLISPSSQGKFLGQSSQGTHT
 ||||                           .|.|| |.. || | |   .|   .||   |  |   |. .  |  ..|   . . . . .  .|   
dyina...........................rmiwetnasvivvlgdt..ddknnfwpekedyqlh.pavilgewytdslyvrtdkvhantsgveglfe

-PLVIqnKEFDDDDQLNVRQYHCSYWPDCCSP
  .||  ...|||   ... .| | ||.   |
vsmvi..hsydddvteklsllhystwpqngvp
0049260 (Phosphotyrosine protein) phosphatases II 1000-1210 1.3e-24 82.0 In-house 1-143 (152) alignment 
Range on Protein: 1000-1210
Range on HMM: 1-143/152.0
FLQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQ---KEDEPIYWptnvdepltlgaltitlwkrntlispssqgkflgqssqgthtplv
|..||....|.| ||.|  .|..|||.||.|.. ||||.||...   |. .. |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

iqnkefddddqlnvrQYHCSYWPDCCSPLHTAFDLIYAVQKRNEflersNKETVGPITVHDRSGGCQAGTFCALSTLHqemiheEAVDIYKTVKLYAAKR
               ||.. .||| . | .. . |.     .       ...  ||. || . |   .||..|.  ..        |.....|.|. .||
...............qylhlpwpDhgvpdlsqlllflllfiekl.....aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekR

PNLITSREDYYYLF
|. ... . ...|.
pgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1001-1066 9.3e-09 29.1 In-house 229-293 (440) alignment 
Range on Protein: 1001-1066
Range on HMM: 229-293/440.0
LQGYRRQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDEPIYWPTNVDePLTLGALTI
..|| ..| .| || |   |. |||... ... .||. | . .     |||| |    .|.| .|.
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntr.svtfgpftv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1006-1211 1.4e-18 61.8 In-house 3-198 (199) alignment 
Range on Protein: 1006-1211
Range on HMM: 3-198/199.0
RQNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTNVDEPLTLGALTITLwkrntlispssqgKFLGQSSQGTHTPLVIQNKEF
 |  ||.||.|  ||| |||.|.||  |  || . ||||. |   |.||||        |.|..|              | .   .. | | |.. |.  
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt.............ktittkpdytitaliltnntt

DDDDQLNVRQYHCSYWPDCCSPLHTAFdLIYAVQKRnEFLERSNKETVGPITVHDRSGGCQAGTFCALSTL--HQEMIHEEAVDIYKTVKLYAAKRPNLI
      .. .|  . | .  .|  . | . . |  | |   . ..|   |. ||   |   .| | ||      .|  .   ||...  |     |  .|
appstreishyqftswkekttpnvalf.vgfvvasr.evskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgii

TSREDYYYLFK
.| . | ....
sslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1007-1211 2.9e-18 60.8 In-house 3-197 (198) alignment 
Range on Protein: 1007-1211
Range on HMM: 3-197/198.0
QNEYIVTQYPSAETMEDFWKMLWEHNSTTIVTLTDDQKEDE---PIYWPTNVDEPLTLGALTITLwkrntlispssqgKFLGQSSQGTHTPLVIQNKEFD
|  ||.||.|  ||. |||.|.||  |  || . ||||. |   |.||||        |.|..|              | .   .. | | |.. |.   
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt.............ktittkpdytitaliltnntta

DDDQLNVRQYHCSYWPDCCSPLHTAFdLIYAVQKRnEFLERSNKETVGPITVHDRSGGCQAGTFCALSTL--HQEMIHEEAVDIYKTVKLYAAKRPNLIT
     .. .|  . | .  .|  . | . . |  | |   . ..|   |. ||   |   .| | ||      .|  .   ||...  |     |  .|.
ppstreishyqftswkekttpnvalf.vgfvvasr.evskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

SREDYYYLFK
| . | ....
slqhynfiyq
0048179 (Phosphotyrosine protein) phosphatases II 1025-1211 1.7e-10 36.3 In-house 22-139 (144) alignment 
Range on Protein: 1025-1211
Range on HMM: 22-139/144.0
WKMLWEHNSTTIVTLTDDqkeDEPIY---WptnvdepltlgaltitlwkrntlispssqgkflgqssqgthtplviqnkefddddqlnVRQYHCSYWPDC
...|.... ||...||..    || .                                                              . ||..  ||| 
lellkklgittvinltee...yepeflere..........................................................giqylhlpwpDh

CSPlhtafDLIYAVQKRNEFLERSNKETvGPITVHDRSGGCQAGTFCALSTLHqemihEEAVDIYKTVKLYAAKRPNLITSREDYYYLFK
. |     ||.  ...  ||.|.  .|  ||. || . |   .||..|.  ..     .. ........|. ..||. ..... ...| .
gvp.....dllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 1028-1213 6.4e-11 37.6 In-house 25-139 (145) alignment 
Range on Protein: 1028-1213
Range on HMM: 25-139/145.0
LWEHNSTTIVTLtddqkedepiywptnvdepltlgaltitlwkrntlispssqgkflgqssqgthtplviqnKEFDDDDQLNVRQYHCSYWPDccsplHT
|.... ||...|                                                                ..   .. ||..  |||     |.
lkdlgittvlnl............................................................tselellerlgiqylylpwpD.....hg

AFDLIYAVQKRNEFLERSNKETvGPITVHDRSGGCQAGTFCALSTLHQemiheEAVDIYKTVKLYAAKRPNLITSREDYYYLFKAL
..||.  ...  ||.|.  ||  ||. || . |   .||..|.  ...     . |.......|. ..||. ... . ...|....
vpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1109-1213 3.7e-08 27.1 In-house 90-190 (440) alignment 
Range on Protein: 1109-1213
Range on HMM: 90-190/440.0
NVRQYHCSYWPDCCSPLHtAFDLIYAVQKRNEFLErsnKETVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYY
 ..|||   |||   |   |  ..  .|  ||  |   |   ||. ||  .|  ..|   |. .. .|  . . .||.  ..    .||... . |.| .
tlkqyhyqgwpdkgvpkf.agpvlkmiqdvnesqe...kagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

LFKAL
...|.
vheav
PTPc_DSPc_SM00012 1110-1214 4.2e-18 60.8 In-house 2-104 (105) alignment 
Range on Protein: 1110-1214
Range on HMM: 2-104/105.0
VRQYHCSYWPDCCSPL--HTAFDLIYAVQKRNEFLERsnketVGPITVHDRSGGCQAGTFCALSTLHQEMIHE-EAVDIYKTVKLYAAKRPNLITSREDY
|..||.. |||.. |   .  ..|. ||.| ..  |.      .|. ||.. |  ..|||.||..|.| . .| . |||...|| .  .||..... |.|
vkhyhytgwpdhgvPeesdsilellravkknknkses.....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy

YYLFKALQ
 .| .||.
lflyrall
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1149-1212 1.6e-06 21.8 In-house 317-380 (392) alignment 
Range on Protein: 1149-1212
Range on HMM: 317-380/392.0
TVGPITVHDRSGGCQAGTFCALSTLHQEMIHEEAVDIYKTVKLYAAKRPNLITSREDYYYLFKA
    | ||  ||  ..| ||.      .. . ..|||..|||.  | | . . . |.| .... 
kefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafvydv