Gene PTPRN in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRN
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP077_AA protein Get Run
SpurP077_AA_246-525 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 233-527 2.1e-84 278.8 In-house 3-292 (297) alignment 
Range on Protein: 233-527
Range on HMM: 3-292/297.0
WSEEPVQSNMDISTGHVVLSYMEDHLNNKDRMSKEWEALCSYEADpctQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSA-NKSDYINSSAIMDIDPR
. .........|..... | .. ...|.| .. .|.| |.|.  |   .  .. ||| .||| |. .||||.||||. | .  . ||||| | .   | .
plrdallesipiplsvldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydll

APAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRCRYWPDEGSaLYHFYEVHLVSEHVwCEDYLVRSFYLKNleTQETRTVTQFHFLTWPE
 ...||||.|| .|..|||.|.||||. |||.||   | .   ..|||.||.  |. . |.|..... ...| || . ..|  ..|.||||.|... ||.
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwpd

TGCPPSPKSLLEFRRKVNKSFRG--RACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAI
 |.|||...|||| ..|.. ..   . .|..||||.|||||||.....|.|... |. ...|.  .....| ||||.|||  |..|   |..| .. .
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRN_pd Subfamily PTPRN 234-529 7.4e-176 578.0 In-house 1-297 (297) alignment 
Range on Protein: 234-529
Range on HMM: 1-297/297.0
SEEPVQSNMDISTGHVVLSYMEDHLNNKDRMSKEWEALCSYEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRAP
|||||.||.|||||||||||.||||.||||..|||||||.|||.|.|....||..|..|||.|...||||.||||.||.||.||||||.|||.| |||||
seepvvsnldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap

AYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVSEHVWCEDYLVRSFYLKNLETQETRTVTQFHFLTWPET
||||||.|||.|.||||||.||||.|||||||...|.....| ||||||||..||.|||||||||.||.||||||||||||.|.|||||||||||.|||.
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpee

GCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAILK
|.|.|.|||||||||||||.|||.||||||||||.||||.|.|.||||.|.||||||.||||||||.||||||.|.|..|||||||||.||||||||
gvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnailk
0050432 (Phosphotyrosine protein) phosphatases II 236-528 7.8e-90 296.6 In-house 17-303 (308) alignment 
Range on Protein: 236-528
Range on HMM: 17-303/308.0
EPVQSNMDISTGHVVLSYMEDhLNNKDRMSKEWEALCSYEAdPCTQDAGKAPENANKNRVKNAIPYDHTRVKLteetsANKSDYINSSAIMDID-PRAPA
.... ..   . . .| ..|. .... ....|.|.|.|.   ... .... ||| .||| |. .||||.||||      ..||||| | ..  .  .  .
tsilvsslklsvldllkllek.aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprk

YIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETD-INRCRYWPDE---GSALYHFYEVHLVSEHVwCEDYLVRSFYLKNLETQETRTVTQFHFLTWP
.||||.|| ||..|||.|.|||.. ||| ||   | . .. ..|||.|   ||  |. . |.|.||.| ..|| || ..|.||...|.||||.||...||
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWp

ETGCPPSPKSLLEFRRKVNKSFRGraCPIVVHCSDGVGRTGTYCLLDLVLTRMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAIL
. |.||||..||.| ..|.||..|  .|||||||.|||||||...|||.| .. |. ...|.  .. ..| ||||||||  |..|   |..| .. .|
dhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0045450 (Phosphotyrosine protein) phosphatases II 238-521 1.3e-82 273.3 In-house 3-301 (307) alignment 
Range on Protein: 238-521
Range on HMM: 3-301/307.0
VQSNMDISTGHVVLSYMEDHLNNKDRMSKEWEALCSYEAD-PCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSA-NKSDYINSSAIMDI-------
.. .. |.. . .| .....|... .. ||.| |.|.. . ... .... ||| .||| |. .|||||||||. ...  . ||||| | ...        
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

DPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDIN-RCRYWPDEGSA-LYHFYEVHLVSEHVwCEDYLVRSFYLKNL-ETQETRTVTQFH
  .  ..||||.|| .|..|||.|.||||. |||.||.  | . .  ..||||||.   |. . |.|.||.. ...| || . ...| .|.|.||||.||
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfh

FLTWPETGCPPSPKSLLEFRRKVNKSFRG--RACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVKE--LDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
...||..|.|||...||.| ..|.| ..   . .|..||||.|||||||.....|.|... |. .   .|.  .....|.||||.||.. |..|   |. 
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0051299 (Phosphotyrosine protein) phosphatases II 241-522 7.6e-90 296.5 In-house 2-284 (288) alignment 
Range on Protein: 241-522
Range on HMM: 2-284/288.0
NMDISTGHVVLSYMEDHLNNKDRMSKEWEALCSYEADpCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQA
...||. ...  ... ..|.. .. .|.|.|.|. .| .|. |.. ||| .||| .. .||||.||||. . . . ||||| | | |. ..  ..||||.
dteisveellklvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqg

PLANTLADFWQMIWEQGSVVIVNLTHMSETD-INRCRYWPDEGSALYHFYEVHLVSEHVwCEDYLVRSFYLKNL----ETQETRTVTQFHFLTWPETGCP
|| ||..|||.|.|||.. ||| ||   | . .. ..|||..||  |. . |.|.||.| ..|| || ....||     ..|.||||.||...||. |.|
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

PSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
.||..||.| |.|.|... . .|.|||||.|||||||...|||.| ...|. ...|.  .....| ||||||||  |..|   |..|
dspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0043336 (Phosphotyrosine protein) phosphatases II 244-521 2.6e-81 268.4 In-house 2-274 (278) alignment 
Range on Protein: 244-521
Range on HMM: 2-274/278.0
ISTGHVVLSYMEDHLNNKDRMSKEWEALCSYEAdpCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQAPLA
||. . .  ..| .||.| ....|.| |.|.    .|.. .. ||| .||| |. .||||.||||. ... . ||||| | . |  .. ...||||.|| 
isvkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlp

NTLADFWQMIWEQGSVVIVNLTHMSETD-INRCRYWPdEGSALYHFYEVHLVSEHVwCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLL
.|..|||.|.||.|. .||.||   | . .. ..||| .||  |. . |.|..|.. ..|| || . ..|| . |.||||..|.| ||. |.|.|...||
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

EFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVkELDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
.| ..|.. .. .  |..||||.|||||||...|.|.|... |.  ..|.  .....| ||||.|||. |..|   |. 
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 246-523 1.1e-66 220.3 In-house 18-290 (319) alignment 
Range on Protein: 246-523
Range on HMM: 18-290/319.0
TGHVVLSYMEDHLNNKDRMSKEWEALCSYEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDpRAPAYIATQAPLANT
. .  ||  .|  ... ..  |. ..|   .. ..|.    ..| .|||. | ...|...|||      . |||||.| .     |   |||.| || ||
ayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldnt

LADFWQMIWEQGSVVIVNLThmsetdINR-CRYWPDEGSALYHFYEVHLVSEHVwCEDYLVRSFYLKN-LETQETRTVTQFHFLTWPETGCPPSPKSLLE
|||||.||||. .  || ||       .. ..||| ..   .  ..|.. | .  ...| ||.. | .  . .. | .|||||| ||. | | .|  |. 
ladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsvee.taeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmr

FRRKVNK--SFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEE
. .||..  |      .|||||| ||||||.|  || .| || |  | .|.  ... .|.||. .||  .|. |  .|..||
lvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm.keekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
0040438 (Phosphotyrosine protein) phosphatases II 250-523 2.4e-85 281.9 In-house 6-275 (317) alignment 
Range on Protein: 250-523
Range on HMM: 6-275/317.0
VLSYMEDHLNNKDRMSKEWEALCSYEADpcTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADF
.| ..  ..... ....|.| |.|.  |  | . .. ||| .||| .. .||||.||||. ... . ||||| | . |.  . ...||||.|| ||..||
llalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntvedF

WQMIWEQGSVVIVNLTHMSETD-INRCRYWPDEGSALYHFYEVHLVSEHVwCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKV
|.|.||||. |||.||.  | . .. ..|||....  |. . |.|.||.. .... .| . ...|...|.||||.||...||. |.||||..||.| ..|
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

NKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVkELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEE
....... .|..||||.|||||||.....|.| .. |.  ..|.  .....| ||||.||| .|..|  .|. | 
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalley
subfamily_PTPRB_pd Subfamily PTPRB 252-522 1.5e-68 226.0 In-house 15-283 (293) alignment 
Range on Protein: 252-522
Range on HMM: 15-283/293.0
SYMEDHLNNKDRMSKEWEALCSYEADPCTQDAgKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRaPAYIATQAPLANTLADFWQ
 ... . ... |.|.|.| | . . |  .. | ....|..||| .| .||||.||||.. .. ..|||||.. | .   .   .|||| || .|. |||.
hvkkmkadsdlrfseeyeelkavgkdqavkaa.elavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsp.refiatqGPlpetvddfWr

MIWEQGSVVIVNLTHMSETDINRC-RYWPDE-GSALYHFYEVHLVSEHVwCEDYLVRSFYLKNleTQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVN
|.||. | .|| ||.. |    .| .|||..  . ||   .|.||.|..  ||. .|.. ...  ..|.|.|.|.||..||. | | ..|.||.| |.|.
mvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee.ledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvr

KSF--RGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKgVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
..     .. ||||||| |||||||.  || .| .. .    .||.... ..| .|  .|||..|. |  ..|..
eaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 252-525 2.5e-66 218.9 In-house 12-284 (305) alignment 
Range on Protein: 252-525
Range on HMM: 12-284/305.0
SYMEDHLNNKDRMSKEWEALCSYeADPCtqDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQ
  .|.. .... . .....|..   ...  | ||  .|..|||.|. ...|. |..|||. | ..|||||.| . |   |  .||..|.|| ||.||||.
yikearvysdkgleaqykslyee.eesi..dvgkkeankaknrlkeitlldddriiltekeslddsdyinasyv.dgykrkkkyivaqgPlkntvadfWr

MIWEQGSVVIVNLTHMSETDINRCR-YWPDEGSA--LYHFYEVHLVSEHvWCEDYLVRSFYLKN-LETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRK
.|.|   ..|| ||.. | . ..|| |||.. .    .  ..|.| ||.   .||. | . . .  | .|.|||.|... .||. | | .. |||.. ..
liveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek.tasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikr

VNKSFR-GRACPIVVHCSDGVGRTGTYCLLDLVLTRmLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVN
|.|. . ..  |..||||.||||||... .|. | | ||  ...|..  | ..| .|..||||..|. |   |. |...
vqkdqkkdkgvpllVhCsagvgRtGvfiavdialer.lkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Ptp69D_pd Subfamily Ptp69D 252-523 8.3e-65 213.9 In-house 12-285 (307) alignment 
Range on Protein: 252-523
Range on HMM: 12-285/307.0
SYMEDHLNNKDRMSKEWEALCSYEADPcTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRApAYIATQAPLANTLADFWQ
..   . . .  . ||.| | . | |  .  ...  ||| ||| ......|.|||||.. .  ..|||||.| |   . .   .|| |.|. .|. |||.
alksrkrdtdfglakeyekLeareidk.stkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekk.kfiaaqdPveatigDfWR

MIWEQGSVVIVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVSEHVwCEDYLVRSFYLKNLE-----TQETRTVTQFHFLTWPETGCPPSPKSLLEFR
||.|| . .|| |. ..|.. ..| .|||.|    |    |.||||.  ..||  |.... . .      ...| |.|.|...|...  | ....||.. 
miaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkli

RKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEE
..|..  .    ||||||| ||||.|..  ||..| .. |  ...|| .|  ..| ||. .||  .|..|   |... 
eqvrelyklnrsPivvhCsaGvgrsgifvaldsllqql.kaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
0047943 (Phosphotyrosine protein) phosphatases II 253-522 7.8e-84 276.7 In-house 3-270 (273) alignment 
Range on Protein: 253-522
Range on HMM: 3-270/273.0
YMEDHLNNKDRMSKEWEALCSYEAdPCTQDAGKAPENANKNRVKNAIPYDHTRVKLteetSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQM
.. ..|...... .|.|.|.|.   ..|  ... ||| .||| |. .||||.||||    . ..||||| | . |  .. ...||||.|| ||..|||.|
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrm

IWEQGSVVIVNLTHMSETDI-NRCRYWPDEG---SALYHFYEVHLVSEHVwCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKV
.|||.. ||| ||   | .  . ..|||.||   |  |. . |.|.||.. ..|| || ..|.||.|.|.||||.||...||. |.|||..||||| ..|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

NKSFRG--RACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
.| ..   .  |.|||||.|||||||...|||.| .. |. ...|.  .. ..|.||||||||  |..|   |..|
rkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 253-526 1.4e-71 236.2 In-house 14-285 (319) alignment 
Range on Protein: 253-526
Range on HMM: 14-285/319.0
YMEDHLNNKDRMSKEWEALCSYEADpcTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRApAYIATQAPLANTLADFWQM
... . . .  . ||.. |   ..|  | |  . .|| .||| .| ..||.|||.|.|    ..|||||.| |   . |  ..|||||||.||. |||.|
lkalastgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqere.kfiatqaPlentiedfWrm

IWEQGSVVIVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVSEHvWCEDYLVRSFYLKNLETQ-ETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNK
.||..| ..| ||...|    .. .|||.|    |  . | | .|.   ||| .| . |... .. |||.|..|... ||. . | . .|||.. ....|
vWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeee.eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

SFRG-RACPIVVHCSDGVGRTGTYCLLDLVLTRMLKgVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNA
| ..  . |||||||.|||||||.. || .| |. .    ||.  |  ..| ||. |||...|..|   |..| |.|
srektqsgPivvhCsaGvGRtGtfivldamlervke.egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
0036941 (Phosphotyrosine protein) phosphatases II 254-523 1.8e-81 269.0 In-house 5-276 (297) alignment 
Range on Protein: 254-523
Range on HMM: 5-276/297.0
MEDHLNNKDRMSKEWEALCSYEAdPCTQDAGKAPENANKNRVKNAIPYDHTRVKLteetSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMI
. ..|... ...||.| |... . ... .... ||| .||| |. .|||||||||    . ..||||| | . |.  .  ..||||.|| ||..|||.|.
llekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmv

WEQGSVVIVNLTHMSETDI-NRCRYWPDE--GSALYHFYEVHLVSEHVW-CEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVN
|||.. |||.||   | .  . ..|||.|  .|  |. . |.|.|..|. ..|| .| . .......|.||||.||...||. |.|.||.|||.| ..|.
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

KSFRG--RACPIVVHCSDGVGRTGTYCLLDLVLTRMLK--GVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEE
|  .   .  |..||||.||||.||....||.| .. .    ...||  .. ..|.||||.|||  |..|   |. | 
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
subfamily_PTPN23_pd Subfamily PTPN23 254-528 1.2e-64 212.9 In-house 7-284 (288) alignment 
Range on Protein: 254-528
Range on HMM: 7-284/288.0
MEDHLNNKDRMSKEWEALCSYEADPC-TQDAGKAPENANKNRVKNAIPYDHTRVKLTeetsANKSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQM
 .  |..|  . |... | ....     .    |  ...||| .. .||||.||||      .| |||| | . |. | .| .|||||||..||.|||.|
qrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlm

IWEQGSVVIVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVSEHVW-CEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNK
..|| | ||| |.. .|.. ... |||| .  .  .| ....  ..|   | .  | . |. |.......|.  .. .||| | | ||..||.|  .|..
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeves

S----FRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAIL
.     |    |.||||| ||||||...|.  ... . ||   |||   ....| ||  |||...|..|.. ||.|... .|
ayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 254-339 3.3e-09 30.8 In-house 15-94 (95) alignment 
Range on Protein: 254-339
Range on HMM: 15-94/95.0
MEDHLNNKDRMSKEWEALCSYEADPCTqdAGKAPENANKNRVKNAIPYDHTRVKLTeetSANKSDYINSSaIMDIDPRAPAYIATQ
.| | |  . . .|. ..      | |  .| .  |  |||. | .||| ||| ||   .   |||||.  ..|   |  .|||.|
lemhsnsdqefdnefksismtsgapyt..vgsseanipknrflnifpydatrvvlt...tkrdsdyinac.fvdgyarkncyiaaq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 254-331 5.1e-09 30.0 In-house 11-89 (440) alignment 
Range on Protein: 254-331
Range on HMM: 11-89/440.0
MEDHLNNKDR--M-SKEWEALCSYEADPCtQDAGkAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPR
. |...|. |      ||  | |  ..|. . |.  |.|  ||| .| . |||.|| | |  .  .|||||.| |  |. |
fadyvqnnrrsrafedewsllpsglsqps.dias.lpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
subfamily_PTPN6_pd Subfamily PTPN6 255-522 4.2e-73 241.0 In-house 19-295 (306) alignment 
Range on Protein: 255-522
Range on HMM: 19-295/306.0
EDHLNNKDRMSKEWEALCSYEA-DPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTeETSANKSDYINSSAIM-DIDPRAPAYIATQAPLANTLADFWQM
|..  .|  ...|.|.|   || .  ... |. |||..||| || .|.|||||.|. | |   |||||.. |. ..     .|||||  | .|..|||.|
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

IWEQGSVVIVNLTHMSETDINRC-RYWPDEGSALY-HFYEVHLVSEhVWCEDYLVRSFYLK-NLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVN
.|.. | ||| .|.  |   ..| |||||| .      ..|. |||    .|| .|.. .. . . .|.|.| |.|| .||. |.| .|. .|.| ..||
vwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

KSFRGRA----CPIVVHCSDGVGRTGTYCLLDLVLTRMLK-GV-KELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
.  .  .     |||||||.|.|||||. ..|..|  . | |.  ..||  . . .|.|| |.|||..|. |  .|. .
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 255-526 5.9e-61 200.9 In-house 13-285 (290) alignment 
Range on Protein: 255-526
Range on HMM: 13-285/290.0
EDHLNNKDRMSKEWEALCSYEADpCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSAN--KSDYINSSAIMDIDPrAPAYIATQAPLANTLADFWQM
..| ...... .....| | | .  |   | ...| ..|| .| ..||  |. | . .. .  . .||| . | .    . .|||||.|. |||.|||..
nghakgnegfrnqfkmldsgese.htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke.kkqyiatqgpvsntlvdFWkl

IWEQGSVVIVNLTHMSETDINRCR-YWPDEGSALYHFYEVHLVSEHVWCeDYLVRSFYLKNLET-QETRTVTQFHFLTWPETG-CPPSPKSLLEFRRKVN
||.. . .|| ||.. | . ..|. ||||.... |  ....|..|..   .|  | . .|| .. .....|||... .|..|| ..    .|| ... ..
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

KSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKgVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNA
. ..    .|||||||.|||....| ..  . .. .     |. . |.. | |.||.|||. |...  . |.. .. 
tqrkrgntsivvHCSdtvgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 255-526 4.4e-57 188.3 In-house 13-280 (287) alignment 
Range on Protein: 255-526
Range on HMM: 13-280/287.0
EDHLNNKDRMSKEWEALCSYEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTeetsANKSDYINSSAIMDIDpRAPAYIATQAPLANTLADFWQMIW
..| ....  .. .  | . . ..     . |..| .|||... ...|  || |      .. ||||.. |      . |.|....|..||. .||..|.
kghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWklid

EQGSVVIVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVSEHvWCEDYLVRSFYLKNLE-TQETRTVTQFHFLTWPETG-CPPSPKSLLEFRRKVNKS
..   .|| |..  |.| . | .|||.| | ..  |...|..|.   ..|..| . .|| . ......|.|... .|..||  .    .|| . ... . 
drnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

FRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKgVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNA
 .    .|||||||.|||....|  .  . .  .    .|.   |.. | |.||.||| .|..|   .|.| ...
rkrgntsivvhCsdtvGrsamfcaaattinkckt.eGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPRD_pd Subfamily PTPRD 256-526 4.5e-90 297.9 In-house 17-283 (564) alignment 
Range on Protein: 256-526
Range on HMM: 17-283/564.0
DHLNNKDRMSKEWEALCSYeaDPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDpRAPAYIATQAPLANTLADFWQMIWE
 . |.. ....|.. . .   .  | .| ..|.| .|||..| ..|||.||.|..    ..||||| | |   . .  ||||||.|||.|..|||.|.||
lkansdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvwe

QGSVVIVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVSEHVwCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRG
| | .|| ||...| . ..| .|||..|.. |  ..| |..|.   .|| .|.| ||. ...|.|.|.||||  ||..| | |..|||...|||... . 
qnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeee.ladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnep

RACPIVVHCSDGVGRTGTYCLLDLVLTRMLKgVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNA
 | ||||||| |||||||.. .| .| |. .  | .||  .....| ||. ||||. |. |  .|..| ...
dagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_PTPRG_pd Subfamily PTPRG 256-526 2.7e-67 222.2 In-house 13-289 (563) alignment 
Range on Protein: 256-526
Range on HMM: 13-289/563.0
DHLNNKDRMSKEWEALCSYEA-DPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKS-DYINSSAIMDIDpRAPAYIATQAPLANTLADFWQMI
 | ... ..|.|.||| |  . .  . .. ..||| .|||  | ..||..||||.. .  .|. |||| . |.    .. |.|||| ||..|. |||.||
lhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmi

WEQGSVVIVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVSEHVWCEdYLVRSFYLKNLET------QETRTVTQFHFLTWPETGCPPSPKSLLEFRR
||| . .|| .| . |   . | .||| ..|  |   .| |..|.| .  | ||.. .|||.       .. ..|.|.|. .||..| | ..   | | .
WeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlal.ytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvk

KVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNA
| ... .  | ||||||| ||||||||. || .| .. .  .  ..  .| ||| ||. .|||. |. |   |..| ...
kssaankaeaGPivvHcsaGvgrtGtyivldtllkqi.qqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_ptpA1_pd Subfamily ptpA1 256-493 9.9e-34 111.8 In-house 15-266 (418) alignment 
Range on Protein: 256-493
Range on HMM: 15-266/418.0
DHLNNKDRMSKEWEALcSYEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRapAYIATQAPLANTLADFWQMIWE
.|..   .. .|.  |      |     |    |..|||  | .| .||||.| .    . |||||.  |    |.   .|.|| || ||.||||.|.||
nhikcihkikeefrll.eesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk..qfictqgplpntiadfwrmvwe

QGSVVIVNLTHMSETDINRC-RYWPDE-----------GSALYHFYEVHLVSEHVWCEDYLVRSFYLKNLEtQETRTVTQFHFLTWPETGCPPSPKSLLE
.   .|| |.. ||    .| ||||..           |  ..  | | ||      |  ..       .|  ||| .||...  ||.   |   . . .
nrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe.getrditqyqyegwpdhnipdhtqpfrq

----FRRKVNK--SFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVKELDIA
       . |.      |  ||.|||| |||||||.|   ... .. . .|.|| .
llhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkqldat
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 258-521 2.9e-71 234.9 In-house 17-276 (288) alignment 
Range on Protein: 258-521
Range on HMM: 17-276/288.0
LNNKDRMSKEWEALCSYEADPCtQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQG
 .|.. .|.|...| . | .   ..||. ..||.||| .| .|||..||||..    ...||||.| | | . .  .|||||.|||.|. |||....|. 
arnrtgfseeynsLaalektks.vtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyi.dgekkkkkyiatqgPladtvndfWelvyenk

SVVIVNLTHMSETDINRC-RYWPDEGS-ALYHFYEVHLVSEHVwCEDYLVRSFYLKnlETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGR
.  || ||.. | . ..| .||||..   .|   .| ||...   ||...|.. |.   ... ...||...|.||..| | | . |||..|.|. .    
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveske.ledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

ACPIVVHCSDGVGRTGTYCLLDLVLTRMLKgVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
. ||.||||.|||||||.  || .. .. .  . .|.|.|....| ||. .|||. |.||   ...
tgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 258-524 7.3e-55 181.3 In-house 19-288 (325) alignment 
Range on Protein: 258-524
Range on HMM: 19-288/325.0
LNNKDRMSKEWEALCSyeADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDiDPRAPAYIATQAPLANTLADFWQMI--WE
 ...| ...|.. | |   |. .. .   ||| .||| || ...|..|| |     . .|||||.| . | | .   ..|.||||..|. |.|...  |.
aqdqdgfahefgllps..ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrd.dkkkdvflaaqaPltatindlWrlvldWr

qgSVVIVNLTHMSETDINRCRYWPDE--GSALYHFYEVHLVSEHVWcEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNK---
  . |.| |  . . . . . |||.|   |  .   ||.|..      ||. | . .|. .  |||.| ||.. .|.. | .  | .|. . . |..   
..csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavse

SFRG---RACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVkELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
  .     . ||.||||.||||||..  |  .| ....   ..||   ....| .|| ||.|  |. .  .|.|| .
rvtantkastpilvhcsaGvGrtGvfislysalakviees.rvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 258-521 1.2e-51 170.2 In-house 6-274 (287) alignment 
Range on Protein: 258-521
Range on HMM: 6-274/287.0
LNNKDRMSKEWEALCS-YEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEEtSANKSDYINSSAIMDIDpRAPAYIATQAPLANTLADFWQMIWEQ
.. || . || .||.   |. . |  | .   ...|||  . .|.|.||| |..| .   |||||.  .     .  |.||.|.|.| |. |||....|.
rrvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravlet

GSVVIVNLTHMSETDINRC-RYWPDEGSA-LYHFYEVHLVSEHVWCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKV----NK
 | ... .|.  |   ..| .|||.     .   | | |..  .   .| ||.. | .|||.|.| | |...|.||. . .|.  .|. |  .|    . 
rsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

SF-RGRACPIVVHCSDGVGRTGTYcLLDLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
.     . |.|||.. |.||.|.. |  ||| ..|. . ..|.||.. ..| .| ..||.  |. .   |.|
ardasevGPlvvhddvGiGrsGil.latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 259-528 1.8e-70 232.2 In-house 12-280 (281) alignment 
Range on Protein: 259-528
Range on HMM: 12-280/281.0
NNKDRMSKEWEALCSYEADPcTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRApAYIATQAPLANTLADFWQMIWEQGS
|..  . .|.|.| . . |  |  | ||.|| .||| .| . ||.||||.|.. .....||||.. .  ..  . .|||||.|. ..|..||||.|||  
ndnaGfieeyeklaaigvdn.tataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgek.eyiatqgPvPaslvafWqmvweqkv

VVIVNLTHMSETDINRC-RYWPDEG-SALYHFYEVHLVSEHvWCEDYLVRSFYLkNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRA
 .|| .|.  |..  .| |||||.  .  |  . |. ..|.   . |. | | | . |. |||.|.|.....||..| | ..| |||||..|.|  . . 
saivmvtreieagklkChrYWPddnselkygdvtvkstaee.ekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekkt

-CPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAIL
 .|.|.||| ||||||||  || .. .. .  .|||. |.....| .|  |||| .|.||   ||.. ..  |
kaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_PTPN9_pd Subfamily PTPN9 259-522 2.3e-63 209.0 In-house 11-288 (297) alignment 
Range on Protein: 259-522
Range on HMM: 11-288/297.0
NNKD--RMSKEWEALCSyEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSaIMDIDPRAPAYIATQAPLANTLADFWQMIWEQ
..|.   .|||.... . |.   | .| | . | .||| .. . ||.|||.|...   ..|||||..  .|   .  |.|||| || .|  |||.|.|||
kekgkrGlskeyaeirn.epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinan.fvdGykqkkafiatqGplkktvsdfWrmvWeq

GSVVIVNLTHMSETDINRC-RYWPDEG--SALYHFYEVHLVSEhVWCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNK---
  .|||  |.. |.   .| .|||.|   || . ...|. |.  .  ||| ||.. .|| .|.|.|.|| | ||.||. | | | .|||....|| .   
evlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvev.eeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

----------SFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRmLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
           .. .  ||||||| |.|||||.. ||. |.| |. |  .|.  |....| ||  ..||. |.||   ||.|
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsr.leevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 259-524 4.9e-47 155.3 In-house 17-279 (439) alignment 
Range on Protein: 259-524
Range on HMM: 17-279/439.0
NNKDRMSKEWEALCSYEAD-PCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIdPRAPAYIATQAPLANTLADFWQMIWEQG
|... .....| . | . |  |         .  ||| |.  ..||||| | |     .| |||.  |         |||||.|  .|  |||....|. 
nkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGy.yddklyiatqgpkkettddfwrlviekk

SVVIVNLTHMSETDInrcrYWPDEGSALYHFYEVHlVSEHVWCEDYLVRSFYLKN--LETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGR
.| ||.|| . |.      ||| .. . |    |. |   .   .| .| | . |    |.  ||| |||...||.   |     .|.| | .| .   .
tvtivmltnlvesyk....ywpsdaevcygdiavr.vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandke

-ACPIVVHCSDGVGRTGTYCLLDLVLTRmLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
   |.||||| |||||||   ||. | . ||  ...||   .. .|.||  |||. .|. |   ||.|..
eygpvvvhcsagvGrtGtiialdialeq.lklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 259-516 2.6e-41 136.3 In-house 12-285 (301) alignment 
Range on Protein: 259-516
Range on HMM: 12-285/301.0
NNKDRMSKEWEALCSYEADPCTqdAGKAPENANKNRVKNAIPYDHTRVKLTEETS--ANKSDYINSSAIMDIDpRAPAYIATQAPLANTLADFWQMIWEQ
............| ..| ..||   |   ||.. || ||  .||. |. |.....    . .|||.| | ..  .. ..||.|.|. .||.|||..||..
khsnkfeeqykelkegedksct..vglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqe

GSVVIVNLTHMSETDINRC-RYWPDEGSALYHFYEV--HLVSEHVwCEDYLVRSFYLK---------------NLETQETRTVTQFHFLTWPETGCPPSP
  | || .| . |.  ..| .|||.     ..|...   ||.|.|   |...|.. .|                 .......|.|..   ||. |  . |
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqv.yPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

KSLLEFRRK-VNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFA
.  |.   . . .  .    |.||||||.|.|.|.|| ... |    |     |.    . .| ..||.|.|  |. . 
rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQc.kaegVVdvfqvtkavrrskpgaVtTLeqytsi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 261-526 1.2e-78 259.4 In-house 19-282 (318) alignment 
Range on Protein: 261-526
Range on HMM: 19-282/318.0
KDRMSKEWEALCSYEADPCTQDAgKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVV
.  .|.|.|.|   |. . . ..   | |..|||  | ..||||||||.. .. ..|||||.. | |   |  ||||.||||..|. |||.|.|||.| |
elllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi.dGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVsEHVWCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSF-RGRACP
|| ||...|   ... ||||..||  |    |.|  |.| ..||..|.| ... |..|.|.| |.|. .||..| | |. |||.. |.|.|   .  | |
ivmltqeeergkakvhryWPskgsrsygklvvelk.eevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

IVVHCSDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNA
|||||| ||||||... .| .| |. |  . .|.  | ...|.||. ||||. |.||  ....| ...
ivvhCsaGvGrtGvfiavdilleri.kaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPRA_pd Subfamily PTPRA 261-522 3.2e-72 238.2 In-house 31-293 (330) alignment 
Range on Protein: 261-522
Range on HMM: 31-293/330.0
KDRMSKEWEALCSYEADPcTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDpRAPAYIATQAPLANTLADFWQMIWEQGSVV
  .. .|..|| . . .  | .. .  || .|||| | .|||..|| |..    ..|||||.| |     .   .||.| |...|. |||.||||| |  
nklfreefnalPagpiqa.tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk.ekdkfiaaqGPkeetvedfwrmiweqksat

IVNLTHMSETDINRC-RYWPDEGSALYHFYEVHlVSEHVWCEDYLVRSFYLKNL----ETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGR
|| ||.. | . ..| .||||||.  |    |. | ... ..|| || | ...|    . ...| |.|||| .||. | |  |. .|.. .||.|  .  
ivmltelkerkeekcaqywPdeGlvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs

ACPIVVHCSDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
| ||||||| |||||||.. || || |. |  . .|.  .....| ||| ||||. |.||   .. |
agpivvhcsaGvGrtGtfivldavlerv.kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_PTPN13_pd Subfamily PTPN13 261-525 2.4e-60 199.1 In-house 10-270 (273) alignment 
Range on Protein: 261-525
Range on HMM: 10-270/273.0
KDRMSKEWEALCSYEADPCTqDAGKAPENANKNRVKNAIPYDHTRVKLTEETSanksdYINSSAI-MDIDPRAPAYIATQAPLANTLADFWQMIWEQGSV
..  ..|.. |    .   . . ||  || .||| .| .|||.||||| .|..     |||.| | . ..     |||.| || .| .|||||.||| . 
qqqPaeefkelrelkpldtc.evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkae

VIVNLTHMSETDINRC-RYWPDEGSALYHFYE---VHLVsEHVWCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKsFRGR
||. .|.  |..  .| ||||.. .     ..   |.|. . .  ... ||.. .|..|..|.| |....| .||. | | |...||.| ..|.. ..  
viamvtlekekgkvkchrywPesknkklkvsnrlevell.kvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr.lqtd

ACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVN
| ||||||| |.||.||.  .| ||  . .  ||.|.  .....|.|| |.|||. |. |   |..| ..
agPivvhcsaGiGrsGtlitidvvlglierd.kefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN14_pd Subfamily PTPN14 261-524 1.3e-58 193.4 In-house 22-296 (300) alignment 
Range on Protein: 261-524
Range on HMM: 22-296/300.0
KDRMSKEWEALCSYEADpCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEeTSANKSDYINSSAI-MDIDPRAPAYIATQAPLANTLADFWQMIWEQGSV
. .. .|.| .   ..| .. ...| ||||.|||.|. .||...||.|.  |  |...|||.| | . .  .   ||..|.|| .|. |||||.||||  
egkvfteyeripkkred.allstaklpenaeknrfkdvlPyednrvelsp.tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

VIVNLTHMSETDINRC-RYWPDEGSALYH-FYEVHLVSEH-V-WCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRR-------KV
.|| ||.  |   ... .|.|...|   .  .. . |... .   . .  ... || | ..| |||  . .  ||. |.|. .|. |.. .       |.
livmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

NKSF--RGRACPIVVHCSDGVGRTGTYCLLDLVLtRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
|..   . .  |..||||.||||||   | ||..   |.  .|.||  .|...| ||  .||| ||..|  ..... .
nseveskeskPPvlvhCsaGvGrtGvlilsdlli.atlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 261-523 1.6e-56 186.5 In-house 23-278 (315) alignment 
Range on Protein: 261-523
Range on HMM: 23-278/315.0
KDRMSKEWEALCSYEADPCtqDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIdPRAPAYIATQAPLANTLADFWQMIWEQGSVV
|. . ...|..   .  |   |  |  || .|||  | |.||..||.|      ..|||.|.. |     .   |||.|.|..... |||....|.    
kngfkqdyesipggqlhpl..dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGy.nkkrryiaaqgpnvasvkdfwrlvfeedigk

IVNLTHMSETDINRCR-YWPDEgSALYHFYEVHLVSEHVWcEDYLVRSFylKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPI
|| || . | . ...  ||||.   .|  . | ..|| |  ..| ||..       .. |.| |.|. .||..| | .  .|... |.|..     ...|
ivmltnlvegekrkaekywpdk.kviyGkitvtrkseevn.teytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgai

VVHCSDGVGRTGTYCLLDLVLTRmLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEE
|||||.|||||||.. || || . ..  . .|.   .. .|..| .|||. .|..|   |..| 
vvhcsaGvGrtGtfitldavldq.aeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 261-528 5.4e-36 119.0 In-house 5-263 (267) alignment 
Range on Protein: 261-528
Range on HMM: 5-263/267.0
KDRMSKEWEALCSYEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSAnksdYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVV
.  . ||.| .     .  |     | .|...||. ...|||.||| | ...      |||.| . .   .  |.|.|| || || .||...| .|.  |
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyv.egyktknafivtqdplkntitdfltvihdqkvpv

IVNLTHMSETDINRcrYWPDE-GSAL-YHFYEVHLVSEhVWCEDYLVRSFYLKnLETQETRTVTQFHFLTWP-ETGCPPSPKSLLEFRRKVNksFRGRAC
|| ||.  . .|..  .|| . | |  |.   |    |    .|| . .. || .. . .. || ...  |  .|   |  | |.    | .  .     
ivlltkvftdnirl..fwPPkmgqakkyqdltvehsle.keendyqiitlelk.fknesahnvtlyyykkwnintnnkpylkplfgilaknq..lengnr

PIVVHCSDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAIL
|.||.|||||||.||.  .|  | |. |    .||   | .||.||.|.|.|. .. .    ..|  .  |
PlvvacsdGvGrsGtflvidsqlera.ktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 261-516 3.3e-24 80.1 In-house 23-281 (305) alignment 
Range on Protein: 261-516
Range on HMM: 23-281/305.0
KDRMSKEWEALCSYEADPCTQDAGKAPENAN----KNRVKNAIPYDHTRVKLTEETsanKSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQ
 |.. .|.  |. |     || | .| . |.    ||| ..    |.. ||| . .    |||| .  .         .|..| || .|. .|| |. ..
vdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqn

GSVVIVNLTHMSETDINRC-RYWPDEGSALYHFyEVHLVSEHVWCEDYLVRSF----YLKNLE--TQETRTVTQFHFLTWPETGCPPSPKSLLEFRrkvn
    || | .  |.   .| .|||       ..    .| | |     . |       | ||    ... .| ....  ||. | ||   . ||.     
kveqivmlcktvelgklkcaqywpaaqgeklel.ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslell....

KSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFA
 . ||   ||||||| |.|||||   .. .| .. .  .   .   .  .||||   .|.. |. | 
sairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 262-525 1.1e-73 243.1 In-house 27-291 (298) alignment 
Range on Protein: 262-525
Range on HMM: 27-291/298.0
DRMSKEWEALCSYEA--DPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRApAYIATQAPLANTLADFWQMIWEQGSV
 ....|.. | | .   .  .......||| .|||  . |..|..|| |..| . ..||||| | .   . |  |.||||||| .|..|||.|..|. . 
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedig

VIVNLTHMSETDI-NRCRYWPDEGSALYHFYEVHLVSEHVWCeDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRA-C
.|| || . |.|  .  .||||||.. |   .|.| |...   |. || . ... .....|.| |.|| .||. | |   .|.|...|||..| .     
tiVmltnleeldktkyhkywPdegketygeitvsllskeefa.dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnk

PIVVHCSDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVN
|..|.||.||||.||.. .| || |. |  . .|.  ... .| .|||.|||..|. |  .|| | ..
pvivqCsaGvgRsGtfiaidsvlerv.kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 262-515 5.5e-32 106.0 In-house 16-268 (307) alignment 
Range on Protein: 262-515
Range on HMM: 16-268/307.0
DRMSKEWEALCSYEADPCTQDAGKApeNANKNRVKNAIPYDHTRVKLTEETSAnkSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVI
...  |.. |. .. .  | .| .|  |..||| ..    |..|. .. .  |  |||| .  .  |  .   .|..| || ||  .|| |. ..    .
qalvdefrvlakktpegvtveafsa..ntdknryqdvkcqdkgrivvkfdgla..sdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesv

VNLTHMSETDINRC-RYWPDEGSALYHFYE-VH------LVSEHVWCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVnksfR
. | .. |.   .| .||| |      | |  .      | ....  .. |.    ||   .|..||.... .  ||. |.|.   . ...   |    |
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav....r

GRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEF
.   |.||||| ||||.||   . ||  .|..|.   |.   .| .|.||.  .||.||. .
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyly
0046845 (Phosphotyrosine protein) phosphatases II 264-527 2.3e-83 275.1 In-house 2-277 (284) alignment 
Range on Protein: 264-527
Range on HMM: 2-277/284.0
MSKEWEALCSYEADPC-TQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSA-NKSDYINSSAIMDID----PRAPAYIATQAPLANTLADFWQMIWEQG
. .|.|.|.|.  ..  . .....||| .||| |. .||||.||||. . .  . ||||| | .   |     . ...||||.|| ||..|||.|.|||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SVVIVNLTHMSETD-INRCRYWPDEG-SALYHFYEVHLVSEHVwCEDYLVRSFYLKNLE-TQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFR-
. ||| ||   | . .  ..|||.|| .  |. . |.|.||.| ..|| || ..|.||. |.|.||||.||...||. |.||||..|||| |.|..... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-GRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVK--ELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAI
 .. .|||||||.|||||||...|||.|... |.    ..|.  .. ..|.|||||||| .|..|   |..| .. .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
DSPc_SM00195 265-524 1.4e-77 255.9 In-house 3-262 (263) alignment 
Range on Protein: 265-524
Range on HMM: 3-262/263.0
SKEWEALCSYEADPcTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNL
..| | | ... .  . . .. ..| .||| || .|||||||||..| . ..||||| . | ... .  .|||||.|| .|..|||.|.||... .|| |
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyi.kgankkkkyIatQgPlpstvedFWrmvweekvkiivml

THMSETDINRC-RYWPDE--GSALYHFYEVHLVSEHVWCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVV
|  .| . ..| ||||.|  |.  .. ..|.||...   ... .| . |.. ...|||.|||... .||. |.| |.||.||. |.|.|| .    ||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSDGVGRTGTYCLLDLVLTRMLKGVKeLDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
|||.|||||||....|..| .. .. | .|| ......|.||||||||..|. |. .|..| .
hCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 265-524 1.4e-77 255.9 In-house 3-262 (263) alignment 
Range on Protein: 265-524
Range on HMM: 3-262/263.0
SKEWEALCSYEADPcTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNL
..| | | ... .  . . .. ..| .||| || .|||||||||..| . ..||||| . | ... .  .|||||.|| .|..|||.|.||... .|| |
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyi.kgankkkkyIatQgPlpstvedFWrmvweekvkiivml

THMSETDINRC-RYWPDE--GSALYHFYEVHLVSEHVWCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVV
|  .| . ..| ||||.|  |.  .. ..|.||...   ... .| . |.. ...|||.|||... .||. |.| |.||.||. |.|.|| .    ||||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSDGVGRTGTYCLLDLVLTRMLKGVKeLDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
|||.|||||||....|..| .. .. | .|| ......|.||||||||..|. |. .|..| .
hCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 265-525 4.8e-59 194.7 In-house 22-278 (315) alignment 
Range on Protein: 265-525
Range on HMM: 22-278/315.0
SKEWEALCsyEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPrAPAYIATQAPLANTLADFWQMIWEQGSVVIVNL
|.|.  |   . |.  | ... ..| .||| || .|.|..||||       .|||||.| |  .|    ||||.|.||  .. |||.|....    || .
seefhdlp..dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmv

THMSETDINRCR-YWPD--EGSALYHFYEVHLVSEHVwCEDYLVRSFYLKNleTQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVV
|...| |  .|| ||||    |. .  ..|.|.| .  . |  .| . ...  ..|.||||||.|  ||. | .    |||.. ..|  . . .  ...|
tkkqegdkikcrqywPdrkadsvefGsikvellslea.dtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllv

HCSDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVN
||| ||||||  . .| |. .. |  . .|.  ... .|..|| .|||. .. |   || |.. 
hcsaGvGrtGvvisidevvaqi.krtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 266-524 1.5e-19 64.7 In-house 26-279 (303) alignment 
Range on Protein: 266-524
Range on HMM: 26-279/303.0
KEWEALCSYEADPCTQDagKAPENANKNRVKNAIPYDHTRVKLTEetsankSDYINSSaIMDIDPRAPAyIATQAPLANTLADFWQMIWEQGSVVIVNLT
.|.| ..||     ...  .  .| .|||  . |  ||..|||..      | || .|  ...| .  | | || ||. | ||||||| ||   ... | 
nefekvvsylppsvskn..qfvknmdknrfvdvicldhskvklsd......ssyihas.yleldsskka.iltqlplshtaadfwqmiieqkvkcvllll

HMSETDIN-RCRYWPDEGSaLYHFYEVH-LVSEHVWCEdyLVRSFYLKNLETQETR--T-VTQFHFLTWPETGCPPS--PKSLLEfRRKVNKSFR--GRA
  || |       .| .   . .| |    | |    |  |.  . || |   .    . .   |. .|| .  |    || . .   ...  .|    .
tdseydklggdsvfprnqd.flkfeersirvgefkrve..lgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkq.iwqlqsvlrkysds

CPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
 | |     |.||.||..|..     . .    ||.   || .|. |   ||  .|| .  | . | |
tptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_PTPN1_pd Subfamily PTPN1 267-528 1.9e-64 212.2 In-house 7-275 (290) alignment 
Range on Protein: 267-528
Range on HMM: 7-275/290.0
EWEAL---CSYEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSanksDYINSSaIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVN
 ....   .. ||.  .. . | ||| |.|| ..  ||||.|.|| ..      ||||.| .....     || || ||.|| . ||||.||| |  .| 
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinas.lveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LTHMSETDINRC-RYWPDEGS--ALYH---FYEVHLVSEHVwCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKS--FRGR
| .. | . ..| .||| . .  .|      ..|.|.||..  . | || . |.||.|||||....||..|||. | | || ..|.|  || .|  .   
lnkvvekeqikcaqywPqgeeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssd

ACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVK--ELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAIL
  | |.||| |.||.||.||.| .| .. |  .   .||  .| ..| .| |..||. |..|. .|..| .. | 
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvik
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 267-523 5.7e-64 211.3 In-house 3-254 (284) alignment 
Range on Protein: 267-523
Range on HMM: 3-254/284.0
EWEALCSYEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDpRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTh
|. ..|   .. ..|     ..| .|||. . ...|...|||      . |||||.| |     |   ||||| || |||||||.||||. .  || || 
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt.

msetdIN-RCRYWPDEGSALYHFYEVHLVSEHVwCEDYLVRSFYLKN-LETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNK--SFRGRACPIVVH
      .  ..||| ..   .. ..|.. | .  .|.| ||.. | .  . .. |...||||| ||. | | .|  |. . .||..  |      .||||
.....kdkcsqywplkivikeerfkvkvdsvee.seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

CSDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEE
|| ||||||.|  || .| || |  | .|.  ... .|.||. .||  .|. |  .|..||
csagvgrtgvyivldvlldrm.keekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 267-524 3.5e-57 188.8 In-house 29-284 (297) alignment 
Range on Protein: 267-524
Range on HMM: 29-284/297.0
EWEALCSYEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPrapAYIATQAPLANTLADFWQMIWEQGSVVIVNLTH
. | ||  ||   .|   .   | .|.| || .|||  ||||    .  .|||.|.| .  .      .|.|| |  .|.||||.|....   .|| |..
seeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnd

MSETDINRCRYWPDEGSALYHFYEVHLVSEHvWCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPP--SPKSLLEFRRKVNKSFRGRAC-PIVVHC
 .|.| .  |||.|.|.. .    | | | .  .| .. |.. ... ... .| | |..|. ||.   .   | .|||..   |.|.| ..|  |..|||
dnerdkkcaryWsdkgvttfGdvsvvllsvs.ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhc

SDGVGRTGTYCLLDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
. |||||| .. .| |.... |  ||.||  .....|..|| .|||. |..|   ||.| .
laGvGrtgvlltidsvvaea.krekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 271-358 6e-11 36.4 In-house 21-110 (347) alignment 
Range on Protein: 271-358
Range on HMM: 21-110/347.0
LCSYEADPCTQDagKAPENANKNRVKNAIPYDHTRVKLTEETSAN-----KSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGS
|..|    .|    .   . .||| |.    | ||| |. | | |        |||.| |  .|     || || || .|. |||.|.     
lanyspskftsv..ewekslsknrskdvklidatrvvlspeksknsraddvetyinashi.kfdnaskeyiltqyplpdtvrdfwkmvsvtkv
subfamily_PTPRK_pd Subfamily PTPRK 273-523 3.8e-65 214.8 In-house 27-276 (314) alignment 
Range on Protein: 273-523
Range on HMM: 27-276/314.0
SYEADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSsAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETD-
 ||. .   || |  || .|||... ..||..||.|.     ..|||||. |..|   |. |.|.|| || .|..|||........  || ||.. |.  
eyeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyina.alidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgr

INRCRYWPDEGSAlYHFYEVHLVSEHVwCEDYLVRSFYLKN--LETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGR
.. ..|||....  |   .|.||. ..  ....|| | ...     .|.|.| ||.||.||. . | | ..||.. |.|.||   .| .|||||| | ||
vkClkyWPedtev.ygdikvelvetel.laelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGr

TGTYCLLDLVLtRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEE
|||.. .| ||  |..  . .|.  .   .|.... ||.|. |. |   ...| 
tGtfiaidivl.dmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 273-522 4.6e-23 76.6 In-house 21-268 (285) alignment 
Range on Protein: 273-522
Range on HMM: 21-268/285.0
SYEADPCTQDAGKApeNANKNRVKNAIPYDHTRVKLTEetsaNKSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDI
 |    ||  | .|  | . ||  .    . ||| | .       ||| .| .        .||.|| || .||.|||.||...    .. |  . |  .
gymppnctytayea..npdlnryadvrcieetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggv

NRCR-YWPDEGSALYHF--YEVHLVSE-HVWCEDYLVRSFYLKNLETQETRT--VTQFHFLTWPETGCPPSPKSLLEFRRKVNKsFRGRACPIVVHCSDG
..|  |.|..   . .|  ||. |           .. .. . | |   .    . . .   ||.  .|   . ..|. . |.|    .  ||.|||| |
ekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsag

VGRTGTYCLLDLVLTRMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
|||| |.  .|    |...   ....   .  .|  |   ||.. || |    ..|
vgrtatfvgidyatirimen.pniemldivremramrfqavqshmqflflyvvlme
subfamily_PTPN12_pd Subfamily PTPN12 275-531 1e-70 233.0 In-house 25-284 (290) alignment 
Range on Protein: 275-531
Range on HMM: 25-284/290.0
EADP-CTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPrAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDIN
 |.  ....||...|| .||| |. .|||..||.|..... ..|||||.. |   .    .|||.|.||..|| |||.||||.   ..| . .. | . .
kaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

RC-RYWPDEGS-AL-YHFYEVHLVSEHVWCEDYLVRSFYLKNLetQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRT
.| ||||.||  .| .  .|| | .|.   .|.|.|.. ...   .|.|.|.|||.  ||. |.| |.|||||. ..|..  .  . |.||||| |||||
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrt

GTYCLLDLVLTRMLKGVK--ELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNAILKAL
|| . .|.| . . ..    |||.   . ..| ||. .|||. |.|.   ||.| |.. |...
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleii
subfamily_CG7180_pd Subfamily CG7180 275-522 1.1e-46 153.8 In-house 30-288 (296) alignment 
Range on Protein: 275-522
Range on HMM: 30-288/296.0
EADPCTQDAGKapENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINR
| . | .. .|  || .|||  . .|||..|| |..    .||||||.. . |   .  .|| |.||  .|. .||........  .|.||.  .     
eigdCagglrk..enreknrdvkvvPyDynRvvLekldGeeksdYinavyv.dsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmy

CRYWPDEGSALYHFYEVHLVSEHVWCEdYLVRSFYLKNL----------ETQETRTVTQFHFLTWPE-TGCPPSPKSLLEFRRKVnKSFRGRA------C
  ||| .. . |   .|..|.|. . .    | | |.            .. |||.|..|.. .|.    .| | ..|.|.||.| ...|...       
psywpnkskeqygeifveiveekqyan.lkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv.rlwrekvdedpeeg

PIVVHCSDGVGRTGTYCLLDLVLTRMLKgVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
|.||..|||..|.| |. .|  |  . |  .|.|.   .  .| .||..|..  .. .    . |
PvvvvssdGasRsGvylaidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 275-448 2.7e-24 80.5 In-house 19-193 (297) alignment 
Range on Protein: 275-448
Range on HMM: 19-193/297.0
EADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEetSANKSDYINSSAIMDIDPRAP-AYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDIN
|| . .  . | .    ||| .. . .| |||||    .  ..||||.  ..  |  |.  || .| || .|. |||....||.  ||| .... |   .
eargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

RCR-YWPDEGSALYHfyEVHLVSEHVW--CEDY-LVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKV
.|  |||.      .    ..| |..    ...  |    |. .  .|.| |.   ||.||. | |   . |  |. .|
kcapywpsvvqerlk..agdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
0045098 (Phosphotyrosine protein) phosphatases II 276-524 7.2e-75 247.2 In-house 20-272 (278) alignment 
Range on Protein: 276-524
Range on HMM: 20-272/278.0
ADPCTQDAGKAPENANKNRVKNAIPYDHTRVKlteetsanksDYINSSAIMDIdPraPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETD-INR
 .|..   .  ..|..||| |. .||||.|||          |||| | |.   |  ...||||.|| .|.||||.|.||.|. |||.||.  | . .  
gipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

CRYWPDEGSALYHFYEVHLVSEHVWcEDYLVRSFYLKNL----ETQETRTVTQFHFLTWPETGCPPSP--KSLLEFRRKVNKSFR-------------GR
..|||..||  |. ..|.|.||.|. .|| .| ... ||    |. |.|.||..|.|.||. |.|..|  ||.||. . ...  .             ..
aqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

ACPIVVHCSDGVGRTGTYCLLDLVLTRMlkGvKELDIAATLEHIRDQRPG-MVQTQAQFEFALTAVVEEV
 .|..|||| |||||||.....|.|...  . . .|.  .....| |||| .||.. |..|   ...| .
ggpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 276-524 2.4e-48 159.5 In-house 32-236 (392) alignment 
Range on Protein: 276-524
Range on HMM: 32-236/392.0
ADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRaPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDinrc
 |   | ... . | .||| || .||| .||||      ..|||.|.| |  .|    ||||.|.| | .| |||.|....    |. .|.. | |    
pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd....

rywpdegsalyhfyevhlvsehvwcedylvrsfylknlETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCL
                                        ...|||.||||  ||. . |    |||.| ..|.  |   . |...||| ||||||    
......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvis

LDLVLTRMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
.| |...  | .. .|.   .  || .|| ||||. |. |   ||.|..
idsvvaha.kktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 276-515 1.3e-30 101.0 In-house 26-260 (281) alignment 
Range on Protein: 276-515
Range on HMM: 26-260/281.0
ADPCTqdAGKAPENANKNRVKNAIPYDHTRVKLTE-ETSANKSDYINSSAIMDIDpRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINR
.| ||  . . | | .|||  |    | .||.|       | .||| .  |         || || |  .| ||||.|||.. .  || | .. ||. ..
sdlct..vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrek

C-RYWPDEGSALYHFYEVHLVSEHVWCEDYLVRSFYLKNLEtQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVnksfRGRACPIVVHCSDGVGRTGTY
|  |.| .  .  .| .. .  |    .  || .      |  ||| .|.. .  ||.   | | . .|.  ||.    | |. | |.||| ||||.|| 
caeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye.getrlithwlwkewpdwqvpessevmlkilrki....rarstppvihcsagvgrsgtl

CLLDLVLTRMLKGVKELDIAATLEHIRD-QRPGMVQTQAQFEF
  ... |  .   .   ||   . |.|   |   |||  |. .
maveialqsihshftlpdikqivshlrvtgraasvqtlqqyml
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 276-394 1.1e-16 55.3 In-house 83-192 (244) alignment 
Range on Protein: 276-394
Range on HMM: 83-192/244.0
ADPCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANksDYINSSAIMDIdPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDinrc
 ||.       |.|. |||   ..|.|  || |.. . .|   |||.| .  .  |.  || || |||.|  |||.|. |.   |.| |  . | |    
pdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgn..tyinasfvgcl.grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....

RYWPDegSALYHFYEVHLV
 ||||  |    .||  . 
eywpd..seplewyeedit
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 278-523 2.4e-45 149.6 In-house 22-265 (283) alignment 
Range on Protein: 278-523
Range on HMM: 22-265/283.0
PCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEETSanksDYINSSAIM--DIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC
.   |   | || .||| .. .|.|  ||.|  |.     ||||.. |.  . . .   ||..|.|| .|  |||.|....  . || ||.. |    .|
dldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

-RYWPDEGSALYHFYEVHLVSEHVwCEDYLVRSFYLKNL-ETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTY
 .||| .||  |  . | |  |    . . .. . |..   ...|  .. . .  | | |  .   ||. | . . .  . .  ||||||| |.|||...
sqyWPkrGsedyGeftvtlrkett.snsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

CLLDLVLTRMLKgVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEE
. .   .  .|     .|. |... .| ||...|||. |. .  ..|.|.
iaasasvkdalt.esvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 278-521 2.4e-31 103.4 In-house 45-280 (290) alignment 
Range on Protein: 278-521
Range on HMM: 45-280/290.0
PCTQDAGKAPENANKNRVKNAIPYDHTRVKLTEetsANKSDYINSSAIMDIDpraPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-R
.  ..   .  . .||| |. .  | ||| | .     . ||. .  .  ..   . .| || .|..|  |.|.|. ...  .|| |  . |    .| .
ylerkifdkntefkknrykdvvcndktrvilkd...GydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceq

YWPDEGSALYHFYEVHLVSEHVWCE--DYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRrkvnKSFRGRACPIVVHCSDGVGRTGTYC
|.|..      | |. ..      .  .   . . ... ..     .  ..  .||.   . |  .||       .. |  . |.||||| |.|||||. 
yypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtl....rilrkasGpvvvhcsaGiGrtGtfv

LLDLVLTRMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
 ..  |  .|.| ||||.. .   .|. | . || . |.   . ...
aievglqilldG.keldlldlvralrnsrlnsvqvdiqylalveill
subfamily_PTPN3_pd Subfamily PTPN3 280-522 2.3e-64 212.0 In-house 32-273 (280) alignment 
Range on Protein: 280-522
Range on HMM: 32-273/280.0
TQDAGKAPENANKNRVKNAIPYDHTRVKLTEetsaNKSDYINSSAI-MDIDPRAP--AYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-
. .| . |||..||| .. .|||.|||||.|    ...||||.. . |.|.  .    ||||| |||.| .|||||.||| | .|| || . |    .| 
aisaarkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

RYWPDEGSAL-YHFYEVHLVSEhVWCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYC
.|||...  | |  ..|.. .|    . |..| ..||. ||.| |...|. .| ||. | | .....||| ..|.|  .|.  |.||||| |.|||| . 
qyWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

LLDLVLTrMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
||.. |. ..   ... . . . ..||||  .|||..|..|   |...
lletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeailk
0040439 (Phosphotyrosine protein) phosphatases II 281-521 2.9e-73 241.8 In-house 3-243 (249) alignment 
Range on Protein: 281-521
Range on HMM: 3-243/249.0
QDAGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSET-DINRCRYWP
 . .. ||| .||| .. .||||.||||.   . . ||||| | | |   . ...||||.|| .|..|||.|.||.|. |||.||.  |   .. ..|||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DEGSALYHFYEVHLVSEHVwCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRG--RACPIVVHCSDGVGRTGTYCLLD
..||  |. . |.|.|..| ..|| || ..|.||...|.|||...... ||..|.|||...||.| ..|.| ..   . .|..||||.|||||||.....
lggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

LVLTRMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
|.|... |  ...|.  .....|.||||.||.. |..| . |. 
lmleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_eak_pd Subfamily eak 281-445 1.9e-20 67.6 In-house 44-204 (332) alignment 
Range on Protein: 281-445
Range on HMM: 44-204/332.0
QDAGKAPENANKNrVKNAIPYDHTRVKLTEeTSANKSDYINSSaIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWP
.  ..  |. |.| | ...|||.  |.||  .  |.  |||.| ...       || | ..  . .  ||||. || |  || | .  | ....  .|.|
isetarleavnrn.vvkivpydrylvrlts.sqlnrlGyinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp

DEGSAL--YHFYEVHLvSEHVWCEDYLVRSFYLKNleTQETRTVTQFHFLTWPETGCPPsPKSLLEFR
|..     . ...|.   |.|  . . .| . |.     ||  |  ...  | ||  |   . .| .|
dktreelkfGildver.kefvkrniletrllelsk..GnethrvlhykvfGwtettlpk.yedflalr
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 283-525 1.7e-67 222.3 In-house 3-243 (250) alignment 
Range on Protein: 283-525
Range on HMM: 3-243/250.0
AGKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRaPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRCRYWPDEG
 .| |.| .|||  . |..|..|| | .| . ..|||||.| .   | |  |.||||.|| .|. |||.|..|. | .|| || ..|.. .  .||| |.
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvek

SALYHFYEVHLVSEHVWCeDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRG-RACPIVVHCSDGVGRTGTYCLLDLVLT
.  |    |.| |....  || .| . | . . .. |.| |.||..||. | |   .. ||...||..| .   . |..|.|| ||||.|... .| || 
aekyGdvtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

RmLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVN
| ||  | .|.   .. .| .||..|....|. |  ... . ..
r.lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
0049772 (Phosphotyrosine protein) phosphatases II 283-527 3e-40 134.3 In-house 40-283 (314) alignment 
Range on Protein: 283-527
Range on HMM: 40-283/314.0
AGKAPENANKNRVKNAIPYDhTRVKLtEETSANKSDYINSSAIMDIdpraPAYIATQAPLANTLADF----------WQMI--WEQGSVVIVN-------
... ..| .||| .. .|.| .||.|    . . |||||.| .  .     ..||||.|| .|. ||          |.|.  ... . .||        
vadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------LTHMSETDinrcRYWPDEGSALYHfyevhlvsehvwC-----EDYlvrsfylknletqeTRTVTQFHFLTWPEtGCPPSPKSLLEF
              |. ...       ... .  .|..                  |..              .|.. ... . .|  |..|... ..||
delsrLdaAlgKtpllildgng....neptaadlellk............eelydpelf..............erlgikylripvpD.gsaplledfdef

RRKVNKSfrGRACPIVVHCSDGVGRTGTYCLLDLVLTRMlkgvkELDIAATLEHIRDQRP-----GMVQTQAQFEFALTAVVEEVNAI
 . ...    .  |..|||..|.|||||........ ..      .... .||..| .||     |..... |.|| | |. | .. .
lefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 283-518 2.8e-30 100.1 In-house 42-281 (305) alignment 
Range on Protein: 283-518
Range on HMM: 42-281/305.0
AGKAPENANKNRVKNAIPYDHTRVKLteeTSANKSDYINSSAIMdIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDE
| |  ..|.||| |.    |. ||||    ..   .|| .  .      .  .| ||||| .| |||| | ...    |  |  . |   ..|  |.. .
afkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvs.tptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask

GSALYHFYEVHLvSEHVWCEDYLVRSFY------------LKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVnksfRGRACPIVVHCSDGVGR
     .| |       | .|     .|             . .   ...| ||..|.  ||. | |..  ..||.  |     |    ||||||| |.||
dkdvlefeekgq.kisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigr

TGTYCLLDLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALT
||.  .|. .| ..| | .  |    | .||.||   .||.||. |   
tgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhq
0042113 (Phosphotyrosine protein) phosphatases II 284-521 2.2e-72 238.7 In-house 4-240 (245) alignment 
Range on Protein: 284-521
Range on HMM: 4-240/245.0
GKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDI-NRCRYWPDEG
.. ||| .||| .. .|||||||||... . . ||||| | . | . . | .||||.||..|..|||.|.||.|. .||.||   | .  . ..|||...
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

SALYHFYEVHLVSEHVwCEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFR-GRACPIVVHCSDGVGRTGTYCLLDLVLT
|  |. . |.|.||.. ..|| || . ..|| . |.|.|...|.| ||. |.|.....||.| . |.|  . ..  |..||||.|||||||.....|.|.
sltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
.. |  .....  .....|.||||.|||. |..|   |. 
qleke.lgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 284-520 2.4e-67 222.3 In-house 5-238 (243) alignment 
Range on Protein: 284-520
Range on HMM: 5-238/243.0
GKAPENANKNRVKNAIPYDHTRVKLteetsaNKSDYINSSAIMDIdPRapaYIATQAPLANTLAD----FWQMIWEQGSVVIVNLTHMSET-DINRCRYW
.. ||| .|||... .||||.||||      . ||||| . |.   ||   .||||.|| .|..|    ||.|.||.|. |||.||.  |   .. ..||
allpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PdeGSALYHFYEVHLVSEHVwCEDYLVRSFYLKNLE-TQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKS--------FRGRACPIVVHCSDGVGR
|  |.  |. ..|.|.||.. ..|| || ..|.||. ...||.|...|.| ||. |.|.||..||.| ..|..          . .  |..|||| ||||
p..gevtygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGTYCLLDLVLTRMlkgvkELDIAATLEHIRDQRPG-MVQTQAQFEFALTAV
|||.....|.|...     ..|.  .....|.|||| .|||. |..|   |.
tGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 284-522 1e-53 177.0 In-house 3-239 (239) alignment 
Range on Protein: 284-522
Range on HMM: 3-239/239.0
GKAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDEG
 |   |  |||  | . |||.|| | . .   .|||||.| . | |    ||||||  .. .  |||.|.|..  .||| || . |   ..| .||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SAlYHFYEVHLVSEHVWCeDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLtR
|  |    | |    |.. ||..|.| . ..   | | | |.||  ||. | |    ..| .|||. |     | | |.||| ||||||.. ..| .| |
sk.ycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml.r

MLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
  |  | .||   .. ||..|| ||||  |. |   ||.|
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 285-524 8.1e-59 194.0 In-house 39-276 (515) alignment 
Range on Protein: 285-524
Range on HMM: 39-276/515.0
KAPENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPrAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPD--E
.   | .||| || .||| .||||     . .|||.|.| |  .|    ||||.|.|.  .. |||......    |. .|...| |  .| .||||   
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

GSALYHFYEVHLVSEHVwCEDYLVRSfyLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLT
 |  .  ..|.||| .  | . . |   |. |  ...||||||||  ||. | |.  .||| . ..|  .    . |...||| |||||| .. .| |..
dsvkfGsikvelvslea.ctggikrk..ltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvva

RMlKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
.. |  . .|.  ... ||..|| .|||| |. |   || |..
ha.kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 285-524 1.1e-55 183.6 In-house 24-268 (274) alignment 
Range on Protein: 285-524
Range on HMM: 24-268/274.0
KAPENANKNRVKNAIPYDHTRVKLTEETSANK-SDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDEG
. . ...||| |. .| ...|| |..|.| .. |.|||.  |   | .  ||.||| ||.||.||||.||... . ||| ||...|.. ..| .|.||. 
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

SA--LYHFYEVHL-VSEHVWCEDYLVRSFYLKNLETqeTRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFR---GRACPIVVHCSDGVGRTGTYCLL
..    .. .|.. |.. | ..|| ||...||.||   .|.|. . .  ||..  | ....||.. ..|..| .    .. |.||||| |.|||| .   
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

DLVLtRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
.. . | |.  . .|.  .  ..| .| |||||. |.|.   |... .
siav.rqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 285-373 3.8e-07 23.9 In-house 30-116 (332) alignment 
Range on Protein: 285-373
Range on HMM: 30-116/332.0
KAPENANKNRVKNAIPYDHTRVKLTEEtsANKSDYINSSAImDIDPRAPAYIATQAPLAN-TLADFWQMIWEQGSVVIVNLTHMSETDIN
|  .| . ||.     .||.||.|. .    | |. |.| . |   .  ||| .|||. . |   ||.|. |.   .|. .  . | .  
kflnnmdmnriphlycfdhsrvelapq..dgkddfynaswv.dgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkr
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 286-522 1e-53 176.9 In-house 4-238 (239) alignment 
Range on Protein: 286-522
Range on HMM: 4-238/239.0
APENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDEGSA
   |  |||  | . |||.|| | . .   .|||||.| . | |    ||||||  .. .  |||.|.|..  .||| || . |   ..| .||||  | 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

lYHFYEVHLVSEHVWCeDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLtRML
 |    | |    |.. ||..|.| . ..   | | | |.||  ||. | |    ..| .|||. |     | | |.||| ||||||.. ..| .| |  
.ycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml.rqa

KGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
|  | .||   .. ||..|| ||||  |. |   ||.|
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 286-526 7.6e-51 167.7 In-house 17-266 (270) alignment 
Range on Protein: 286-526
Range on HMM: 17-266/270.0
APENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDEGSA
|  ... || .. .|  .|||.| |... ... |||   .  .| .  .|||...||..|| .||.||||. .  || .|.. |   ..| |||| |   
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

--LYHFYEVHLVSEH-VWCEDYLVRSFYLKnlETQETRTVTQFHFLTWPETGCPPSPK------SLLEFRRKVNKSFRG--RACPIVVHCSDGVGRTGTY
   ... ... .... .  | |...   |.  |. |.| .. |.. |||. | |...       .||.  |.| .| .   .| |..||||.||||||| 
kvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

CLLDLVlTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNA
 .|| . .|.|.  |..|..| .|..| .|. .||.  |.||.  |||| .. 
ialDia.vrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 288-521 5.8e-50 164.7 In-house 2-236 (237) alignment 
Range on Protein: 288-521
Range on HMM: 2-236/237.0
ENANKNRVKNAIPYDHTRVKLTEETSAnkSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDE-GSAL
||  |||  | . |||.|| |    |.  |||||.. . ..|     |||.| || ..  |||||.|..   ||| || . | .  .| .|||.    | 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YHFYEVHLVSEHVWcEDYLVRSFYLK-NLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKV-NKSFR-GRACPIVVHCSDGVGRTGTYCLLDLVLtR
|  . | |  .  .  || |||. |  .|. .| | . |..| .||. | |    .|| ||... |.|    ...| ..||| |||||| . ..| .| |
ygvltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml.r

MLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
  |  | .||   .  | ..|| ..||. |. |   ...
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_CG42327_pd Subfamily CG42327 288-451 5.4e-31 102.4 In-house 27-193 (319) alignment 
Range on Protein: 288-451
Range on HMM: 27-193/319.0
ENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPD----EG
   .|.|| |..|  .||| | . .. .|. |...| .   |     |||.|..| .. .|||...||| | ||| || .||  |..| .|.|     ..
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

SALYHFYEVHLVSEHVwCEDYLVRSFYLKNLETQETRTVTQFHFlTWPETGCPPSPKSLLEFRRKVNKS
  ||  . | |    |  . |.. .. ||... .|.| .| . .  |.|.. | ....|.    .|..|
tslyGdilvtlkgrev.kdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 288-524 4.2e-26 86.6 In-house 42-271 (288) alignment 
Range on Protein: 288-524
Range on HMM: 42-271/288.0
ENANKNRVKNAIPYDHTRVKLTeetsaNKSDYINSSAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDEGSALY
.|. ..| .|    | |||||.     . .|.   . ..   .     | .||||  |.  .|.|. |..   || |... |   ..   |.| .     
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

HFYE-VHLVSEHVWCEDYLVRSFYLKNLETQETRT-VTQFHFLTWPETGCPPSPKSLLEFRRKVnksfRGRACPIVVHCSDGVGRTGTYCLlDLVLTRML
..      | ..    | ||.   |.. .. |..  | . |.| |.. | | . .| | .   .    .    |||||.| |||||||  |  |.  ..|
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlil.ilialesl

KGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
. .  | |   |.. |..|   .||. |. ..   | ||.
rlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_egg_pd Subfamily egg 288-519 7.7e-21 69.0 In-house 39-265 (307) alignment 
Range on Protein: 288-519
Range on HMM: 39-265/307.0
ENANKNRVKNAIPYDHTRVKLTEETSANKSDYINSSAIMdIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETdiNRCR-YWPDEGSALY
.| .| | |     | .||||  .      |.| .  .   .|    .| .|||| ||  |||.|....    || ||   |.  .||  |||   |   
nnlekarskrvhckdssrvklelrrGqylddfihanrvk.Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

HF--YEVHLVSEHVWC-EDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLefrrkvnKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRM
 .    ... . .|    | | |   || . ...     .     . ...   ||  .|       .  |  . |.||.. .|| ...|   ... |  .
vtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvl.......rklrnlskpvvvqdilGvskaatlvaieiallsl

LKG-VKELDIAATLEHIRDQRPGMVQTQAQFEFALTA
|.| .    .  .   .| .|.  |..  .. |    
lrGpitkslvlravvflrlrrrlsvesvllylfvyrl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 288-382 1.6e-20 68.1 In-house 46-154 (350) alignment 
Range on Protein: 288-382
Range on HMM: 46-154/350.0
ENANKNRVKNAIPYDHTRVKLT--------EETSANKSDYINSSAIM------DIDPRApAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDIN
|   ||| || .||.|.||||          . | . .||||.. .       .|.|    |||||||| .|. ||...| . .  ||. ||   | ...
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf.kYiatqaPlpstvddfykvillnkvkvilsltsdvelnle

RC-RYWPDEG
.| |||.. .
kcyrYWqegs
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 288-515 1.7e-19 64.6 In-house 51-281 (310) alignment 
Range on Protein: 288-515
Range on HMM: 51-281/310.0
ENANKNRVKNAIPYDHTRVKLTEETSAnKSDYINSSAIMDIDPRaPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDEGSA-L
..  |||  . .  | .||||. . |    ||| .  .     |  ..| .| ||  |. |||.||... .  |. | ...|    .|  |||  | .  
kymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylr.stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YHFYEVHLVSEHVW--CEDYLVRSFYLKNLETQETR------TVTQFHFLTWPETGCPPSpKSLLEFRRKVNKSfrgRACPIVVHCSDGVGRTGTYCLLD
|    |  .||         |  .|   |.  .|         |.  ..  ||..| |   |     .| . .    |  | ||||| |..|... . |.
ygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde.kchtvpqrllaqv...rhgpcvvhcsagkdrlyvvvalk

LVLTRMLKGVKeLDIAATLEHIRDQRPGMVQTQAQFEF
| . .. .| | .|.     ... .|   .||. |. .
lkidkldrglk.vdaeevktellksraiciqtelqyli
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 288-517 7.3e-16 52.4 In-house 50-278 (302) alignment 
Range on Protein: 288-517
Range on HMM: 50-278/302.0
ENANKNRVKNAIPYDHTRVKLTEEtsanKSDYINSSAImDIDPRAPAYIATQAPLANTL---ADFWQMIWEQGSVVIVNLTHMSETDINRCRYWPDEGSA
.| .||. ..   .|...|||..|    . .|.| | . ..    .  | .| |  ..    ..||.|....  | .| |    | .     ..| .  .
knlkknqsedvpildsnlvkleae....pdsyvnaskv.evPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgd

LYHFYEVHLVSEHVWCEDYLVRSFYLKNLETQ--ETRTVTQFHFLTWPETGCPPSPKSLLEFRRKV-NKSFRGRAcPIVVHCSDGVGRTGTYCLLDLVLT
  .. .. .    |   .  .  ...  |     ..  ..  ..  |...  | .  .| .   || .|.  . . ..|.    |.|| |.   | ....
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikade.ntvivSknGaGRagafltlavave

RMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFAL
.. || ||  |. ... || ||| .|..  |. .  
klqkg.kepnikeivksiRsqRpravdslkQyvsly
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 288-381 1e-13 45.3 In-house 47-156 (349) alignment 
Range on Protein: 288-381
Range on HMM: 47-156/349.0
ENANKNRVKNAIPYDHTRVKLTEE--------------TSANKSDYINSSA--IMDIDPRApAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETD
|   ||| |. .||.|.|||| .                |.   ||||.    .  |..    ||||||||  |. ||...|  .|  ... |..  |..
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvek.kyiatqaPlPstvddfykvillngvklvlsLnddkels

INRC-RYWPDE
...| .|| . 
lekcdiywqel
Y_phosphatase Protein-tyrosine phosphatase 289-521 1.3e-72 239.4 Pfam-A 1-234 (235) alignment 
Range on Protein: 289-521
Range on HMM: 1-234/235.0
NANKNRVKNAIPYDHTRVKLteETSANKSDYINSSAIMDIDpRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWP--DEGSAL
| .||| |. .|||.|||||  . | ..||||| . ..  . .  ..||||.|| .|..|||.|.|.. . ||| ||.  | . . | .|||  .|.|  
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YHFYEVHLV-SEHVWCEDYLVRSFYLKNLETQ-ETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRM
|. ..|.|. .|. ....| .| . ||. ... |.|.|.|.|. .||. |.| ||||||.. |||.|| . .  |.|||||.|||||||...||..| ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

LKGVKeLDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
 .. . .|.  .....| |||||||. .|..|   |..
eaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 289-521 1.3e-72 239.4 In-house 1-234 (235) alignment 
Range on Protein: 289-521
Range on HMM: 1-234/235.0
NANKNRVKNAIPYDHTRVKLteETSANKSDYINSSAIMDIDpRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWP--DEGSAL
| .||| |. .|||.|||||  . | ..||||| . ..  . .  ..||||.|| .|..|||.|.|.. . ||| ||.  | . . | .|||  .|.|  
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YHFYEVHLV-SEHVWCEDYLVRSFYLKNLETQ-ETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRM
|. ..|.|. .|. ....| .| . ||. ... |.|.|.|.|. .||. |.| ||||||.. |||.|| . .  |.|||||.|||||||...||..| ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

LKGVKeLDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
 .. . .|.  .....| |||||||. .|..|   |..
eaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 289-522 2.3e-46 153.0 In-house 1-169 (182) alignment 
Range on Protein: 289-522
Range on HMM: 1-169/182.0
NANKNRVKNAIPYDHTRvklteetsanKSDYINSSaIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLThmsetdinRCRYWPdegsalyhf
| .|||... .||||.|           .|||| . ... . .|  .||||.|| .|.|||..|..|.|  .|||||         ..|||         
nldknrysdilpydhsr..........dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp.........

yevhlvsehvwcedylvrsfylknleTQETRTVTQFHFLTWPETGCPPsPKSLLEFRRKVNKsfrgRACPIVVHCSDGVGRTGTYCLLDLVLTRmlkgvk
                          . ..|...|...| ||  |.|. . .||.| ..|..    . .|..|||| |||||||.....|....      
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl......

ELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
....  .....| .|||||.|  |. |   |. |
gvsleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 289-439 2.3e-08 27.2 In-house 27-159 (169) alignment 
Range on Protein: 289-439
Range on HMM: 27-159/169.0
NANKNRVKNAIPYDHTRVKLTEETSANKSDYINSsaimdidprapayiatqaplantladfwQMIWEQGSVVIVNLThmsETDiNRCRYWPDEGSALYH-
|  |||    .   ||||||        |||||.                            .||||  . ||| |    .|| ..  .||.      | 
netknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlg...dtd.dknnfwpekedyqlhp

------FYEVHLV--SEHVW-----CEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPK
      .|   |   ...|       |  .  |. ... . . |  .. .|. |||. | | || 
avilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspv
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 289-439 3.4e-08 26.5 In-house 26-158 (169) alignment 
Range on Protein: 289-439
Range on HMM: 26-158/169.0
NANKNRVKNAIPYDHTRVKLTEETSANKSDYINSsaimdidprapayiatqaplantladfwQMIWEQGSVVIVNLThmsETDiNRCRYWPDEGSALYH-
|  |||    .   ||||||        |||||.                            .||||  . ||| |    .|| ..  .||.      | 
netknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlG...dtd.dknnfwpekedyqlhp

------FYEVH--LVSEHVW-----CEDYLVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPK
      .|     . ...|       |  .  |. ... . . |. .. .|. |||. | | || 
avilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 290-521 2.7e-19 64.4 In-house 20-256 (290) alignment 
Range on Protein: 290-521
Range on HMM: 20-256/290.0
ANKNRVKNAIpYDHTRVKLTEETSANKSDYINSSAIMdiDPRAPAYIATQAPLANT-------LADFWQMIWEQGSVVIVNLTHMSETDIN----RCR-Y
. ..|.....   .||| | .  .  ..|||  . .    |   . |.||.|....       . .|| |. .  .  .| |  ..| . |     |  |
emdqRlevpL.veatrvvLkgygkrfnddyiHAnrvt..cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WPDEGSALYHFYEVHLV-SEHVWCEDYLVRSFYLKnLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSfrgrACPIVVHCSDGVGRTGTYCLL
 |..      |  . .   . .  .|  .|   .|  . .|  |||   .  | ..  ....|.||.  .||..|      |..||| ||. |  .   .
vpesvgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaai

DLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVV
.|    . .  ... ... |. .| ||  ..... .. |.. ..|
ilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 291-524 1.6e-16 54.9 In-house 45-276 (312) alignment 
Range on Protein: 291-524
Range on HMM: 45-276/312.0
NKNRVKNAIPYDHTRVKLTEEtsanKSDYINSsAIMDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRCRYWPDEGSALYHFyE
. ||  |   .|  |  |. .    .  || .  .. |  .   ...||.|| || . |||.    ||. |. |. . |   ..|  .  .  .. .. |
dlnrypniqcwdrgrftlagd....enfyiha.nfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdl.e

VHLVSEHVWC--------EDYLV-RSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRgracPIVVHCSDGVGRTGTYCLLDLVLT
 | |               | .  | . .    | .   . .. . .||. | | |  . | .   |.|  .    |.. ||| ||||||| .|.. ...
dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahcsagvgrtgtlaliesmia

RmLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEV
  |.  .  ..  ..  .| .|   |.. .|. .|| .|.| .
a.lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 298-436 1.4e-10 35.5 In-house 2-128 (130) alignment 
Range on Protein: 298-436
Range on HMM: 2-128/130.0
AIPYDHTRVKlteetsanKSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDinrcRYWPDegSALYHFYEVHLVSEH
|.... .|..          .||| | .  .  |.  |. ||.|||.|  |||.|. |.   |.| |  . | |     ||||  |  ...|| ...   
alefevsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpd..sePlewyeediivtl

--VWCEDYlVRSFYLK-NLETQE-TRTVTQFHFLTWPETGCPP
      .. ... .|. . . .|  ...| |.   ||  |  |
tdrdefkn.ikasnleiesdlneshqaltmfqisnwpsdgttp
0044763 (Phosphotyrosine protein) phosphatases II 300-515 6.3e-32 106.0 In-house 1-162 (178) alignment 
Range on Protein: 300-515
Range on HMM: 1-162/178.0
PYDHTRVKLTEETSANKSDYINSSAIMDIdprapAYIATQAPlantlADFWQMIWEQGSVVIVNLTHMSETD-INRCRYWPDEGSalyhfyevhlvsehv
|.|.|||.|..    . ||||| | |..       |.... |     ||......|.|  .|||||.  |   .. ..|||.| .               
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

wcedylvrsfylknletqetrtvTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLTRmlkgvkELDIAATLEH
                        |.... .|  |.|.... .||| . ...    . .|..|||| ||||.|| ....|....       |.. . .|.
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaiel

IRDQRPgMVQTQAQFEF
.| .|| .|... | ..
vrerRp.ivpnpgqlrq
0043147 (Phosphotyrosine protein) phosphatases II 316-516 1.3e-39 131.0 In-house 4-153 (172) alignment 
Range on Protein: 316-516
Range on HMM: 4-153/172.0
KSDYINSSAImDIDPRAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMsetdinrcrywpdegsalyhfyevhlvsehvwcedylvrsfylKNLET
 ||||| | . |.    . .||||.|| |||||||.|..|.|  .|||||                                              .. .
gsdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

QETRTVTQFHFLTWPETGCPpSPKSLLEFRRKVNK-SFRGRACPIVVHCSDGVGRTGTYCLLDLVLtrmlkgvKELDIAATLEHIRDQRPGMVQTQAQFE
...|.. |...| ||  |.| ... |||| . ...   . . .|..|||| ||||||| ....|.|       . |..  .....|..|||.||.. |  
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqyr

FA
| 
fl
0046846 (Phosphotyrosine protein) phosphatases II 316-518 1.4e-36 121.3 In-house 11-167 (176) alignment 
Range on Protein: 316-518
Range on HMM: 11-167/176.0
KSDYINSSAIMDidpraPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRCRYWPDEGSALYHfyevhlvsehvwcedylvrsfylknlet
 .|||| . |.      ...||||.|| .|||||..|..|.|  ..|||| . |..  .| ....|  .| .                            
dldyinanlilg.....srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

qetrtvtQFHFLTWPETGCPPSpKSLLEFRRKVNKSFRGRaCPIVVHCSDGVGRTGTYCLLDLVLTRmlkgvKELDIAATLEHIRDQRP-GMVQTQAQFE
       |...| ||. |.|.. . |||. . ...  .    |..|||| |.|||||.....|. ..     | |..  .|...|.||| |.|||..| .
.......qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpeQyr

FALT
|   
flye
0051429 (Phosphotyrosine protein) phosphatases II 317-526 5.8e-42 139.5 In-house 4-227 (272) alignment 
Range on Protein: 317-526
Range on HMM: 4-227/272.0
SDYINSSAIMDIdPR---APAYIATQAPLANTLADFWQMiWEQGSVVIVNLTHMSETDINR-CRYWP------------DEGSALYHFYEVHLVSEHvWC
|.||| . .     |     .......|| .| ||||.. .|.|  .||.|.. .| . .   ||||            .. . ||... | |.||. ..
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee.ll

EDYLVRSFYLKNL-ETQETRTVTQFHFLTWPETGCPPSPksLLEFRRKVNKsfrgrACPIVVHCSDGVGRTGTYCLLDLVLtRMLKGVKELD--------
.||..| ..|..|  ..|.|.|...|.. ||  | |...  |||. . ...       |..|||| |..||||...|.|.| . .     .|        
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnly

IAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVNA
.....|..|.||||.|||..|..| . |..| ...
leeaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 317-515 1e-36 121.6 In-house 2-161 (174) alignment 
Range on Protein: 317-515
Range on HMM: 2-161/174.0
SDYINSSAiMDIDPRAPAYIATQAPLAntladFWQMIWEQGSVVIVNLTHMSETDI-NRCRYWPDegsalyhfyevhlvsehvwcedylvrsfylknLET
||||| |  .|.  . | .||.|.|||     ||.|..|.|. ..|.|..  | ..   ..|||.                                | .
sdyinasp.ldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

QETRTVTQFHFLTWPETGCPPSPKsLLEFRRKVNKSFRG-RACPIVVHCSDGVGRTGTYCLLDLVLTRMLkgVKELDIAATLEHIRDQRPGMVQTQAQFE
 ..|.. |...| ||  |.|.... |||| . |.. .   . .|..|||| ||||||| ....|.|...|   .  |. ...  .| ||||||||. |..
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyr

F
|
f
0051082 (Phosphotyrosine protein) phosphatases II 317-519 6.4e-33 108.8 In-house 3-148 (151) alignment 
Range on Protein: 317-519
Range on HMM: 3-148/151.0
SDYINSSAIMDIdprapaYIATQAPlantLADFWQMIWEQGSVVIVNLTHMSETDiNRCRYWPDEGsalyhfyevhlvsehvwcedylvrsfylknletq
||||| | . .       ......|    ||||.....|.|  .||||.   |.. .  .|.|..|                                  
sdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg..................................

etRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKsfrGRACPIVVHCSDGVGRTGTYCLLDLVLTRmlkgvkeLDIAATLEHIRDQRPGMVQTQAQFEFA
  ..|.....| ||..|.| |....||| .....    .  |..|||| |.||||| ..|.|.| .       ......||..| .|||.||.  || | 
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfq

LTA
| |
lfa
0049260 (Phosphotyrosine protein) phosphatases II 331-516 5.7e-37 122.1 In-house 7-142 (152) alignment 
Range on Protein: 331-516
Range on HMM: 7-142/152.0
RAPAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRCRYWPdegsalyhfyevhlvsehvwcedylvrsfylknletqetrtvtQFHFLTWP
.  ..||||.|. |||||||.|..|.|  .||.||  .| .   | ...                                           |...| ||
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwp

ETGCPPSPKSLLEFRRKVNKSFRGRACPIVVHCSDGVGRTGTYCLLDLVLtrmlkgvKELDIAATLEHIRDQRPGMVQTQAQFEFA
  |.|...  ||.. . ..|  . . .|..|||| |||||||.....|.|       . ...  .....| .|||.|... | .| 
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 331-522 1.2e-21 71.9 In-house 39-219 (255) alignment 
Range on Protein: 331-522
Range on HMM: 39-219/255.0
RapayiatqaplanTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVSEHvWCEDYLVRSFYL-KNLE-TQETRTVTQFHFL
              |.. |.|.|  ... |.| |. . | ....| .|.| |      . .| ... .    | ..|   .  .|   ..|.||. ... 
l.............tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysyk

TWPETGCPPSPKSLLEFRRKVNKSfRgracPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVK-----ELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
 |.|   |  .. .|.  . | .| .    ..||||| |.||. .. | .||  .|.. ..     |||    ||..| .|.. ..|  |. |..  |..
GWieknaPelareilnilkvvrds.k....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 332-514 5e-24 79.6 In-house 89-271 (301) alignment 
Range on Protein: 332-514
Range on HMM: 89-271/301.0
APAYIATQAPLANTLADFWQMIWEQGSVVIVNLTHMSETDINRCR-YWPDEGSALY--HFYEVHLVSEHVWCEDY-LVRSFYLKNLE-TQETRTVTQFHF
.  .||||.|| ||  ||| |.       || |..  |  ...|. | | . |       ..........  ..    |.. ...     .||||| . .
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

LTWPETGCPPSPKSLLEFRRKVNKSFRgracPIVVHCSDGVGRTGTYCLLDlVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFE
 .|.. | | |   | ..   | || .    |||||||.|.||. ..   . .|.| ..  ...... .|.|.|..|   |||. |. 
sewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigte.ylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 334-515 1.1e-21 71.9 In-house 6-195 (199) alignment 
Range on Protein: 334-515
Range on HMM: 6-195/199.0
AYIATQAPLANTLADFWQMIWEQGSVVIVNLTHM-SETDINRCRYWPDEGSALYHFYEVHLVSEHVW-CEDYLVRSFYLKNLETQ--ETRTVTQFHFLTW
 ||||| || .|.||||||.|| ||  || .     . . .   |||   |.  ..  . .... .    || . .. | |  |    || .... | .|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PETGCPPSPK--SLLEFRRKVNKSFR-GRACPIVVHCSDGVGRTGTYCLLDLVLTRM-LKGVKELDIAATLEHIRDQRPGMVQTQAQFEF
 |   |       ..   |.| | .   . .|..|||||| | || .  ||. .          .|.      .|. | |.. .  ...|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 334-515 1.2e-21 71.8 In-house 5-194 (198) alignment 
Range on Protein: 334-515
Range on HMM: 5-194/198.0
AYIATQAPLANTLADFWQMIWEQGSVVIVNLTHM-SETDINRCRYWPDEGSALYHFYEVHLVSEHVW-CEDYLVRSFYLKNLETQ--ETRTVTQFHFLTW
 ||||| || .||||||||.|| ||  || .     . . .   |||   |.  ..  . .... .    || . .. | |  |    || .... | .|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PETGCPPSPK--SLLEFRRKVNKSFR-GRACPIVVHCSDGVGRTGTYCLLDLVLTRM-LKGVKELDIAATLEHIRDQRPGMVQTQAQFEF
 |   |       ..   |.| | .   . .|..|||||| | || .  ||. .          .|.      .|. | |.. .  ...|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_hpo-7_pd Subfamily hpo-7 337-522 9e-21 68.9 In-house 42-225 (263) alignment 
Range on Protein: 337-522
Range on HMM: 42-225/263.0
AtqapLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDEGSALYHFYEVHLVSEHVWCeDYLVRSFYLKN-LE-TQETRTVTQFHFLTWPETG
     | .|.. |.|.|  ... |.| |. . | ....| .|.| |      . .| ... .|   | |...  | . |.  ..|.||... .  |.|. 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekn

CPPSPKSLLEFRRKVNKSfRgracPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVK-----ELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
 |  ... |.  . . .| .    ..||||| |.||.  . . .||  .|.. ..     |||    ||..| .|.. ..|  |. |..  |..
dpelareilnilkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 340-522 3.6e-16 53.5 In-house 98-286 (302) alignment 
Range on Protein: 340-522
Range on HMM: 98-286/302.0
APLANTLADFWQMIWEQGSVVIVNLTHMSETDINRC-RYWPDEGSALYH--FYEVHLVSEHVWCEDYLV-RSFYLKNLETQE-------TRTVTQFHFLT
 |  .||  .| .| .    ..|.|... | . ..|  |. |.     .   | |. || .   |..   .|| | ..| ..        .||  ..| .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPETGCPPSPKSLLEFRrKVNKSFRGRacpIVVHCSDGVGRTGTYCLLDLVLTRMLKgVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVE
||. | |  ... |.   |  .|..     ..|||| |||||||   .   .   .|  |  |..  .  .|. | | ||.. |  . |  |  
wpdhGapkeaytaldil.kfcesykkn...vlvhcsaGvGrtGtlvaikyGiqlcsk.kkvtdllsivlpvrqcryGavqdeqqliylllcvtk
subfamily_PTPDC1_pd Subfamily PTPDC1 395-515 7.6e-08 27.0 In-house 57-167 (182) alignment 
Range on Protein: 395-515
Range on HMM: 57-167/182.0
SEHVWCEDYLVRSFYLKNLETQETRTVTqFHFLTWPETGCPpSPKSLLEFRRKVNKSFRGRacPIVVHCSDGVGRTGTYCLLDLVLtrmlkgVKELDIAA
 ||  |   | .| .  .||    . .. .. ..|.. | . | ...|.  . |. . .     . |||  | ||||      ||       .|.|. . 
gehasCGagleesGfsYdlealmeqgiy.vynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvy......akrltaek

TLEHIRDQRPGMVQTQAQFEF
... .|..||  .||. | |.
aiklvrskrpksiqtreqvel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 400-524 9.3e-18 58.7 In-house 74-194 (440) alignment 
Range on Protein: 400-524
Range on HMM: 74-194/440.0
CEDYLVRSFylknLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFR-GRACPIVVHCSDGVGRTGTYCLLDLVLtRMLKGVKELDIAATLEH
 .||.  |.    ..  |.||. |.|.  ||. | |     .|.. . ||.|       |..|||| |.||||    .| .| |  |   ..|| . .. 
dsdyinasy....ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsil.reakrsdqidifsfins

IRDQRPGMVQTQAQFEFALTAVVEEV
.|..|| ||||  |. |   ||.| .
mrnnrpqmvqtpeqyafvheavlegl
0048179 (Phosphotyrosine protein) phosphatases II 404-516 4.6e-23 77.0 In-house 32-137 (144) alignment 
Range on Protein: 404-516
Range on HMM: 32-137/144.0
LVRSFYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRgRACPIVVHCSDGVGRTGTYCLLDLVLtrmlkgVKELDIAATLEHIRDQR
.| ..  .   . ..|...|...| ||  |.|.... |||| . ...  . . .|..|||| |||||||.....|..      .. |..  .|...| .|
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrr

PGMVQTQAQFEFA
||.|... |..| 
pgavpnpgqlrfL
0048076 (Phosphotyrosine protein) phosphatases II 408-519 1.5e-24 81.8 In-house 34-138 (145) alignment 
Range on Protein: 408-519
Range on HMM: 34-138/145.0
FYLKNLETQETRTVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRaCPIVVHCSDGVGRTGTYCLLDLVLTrmlkgvKELDIAATLEHIRDQRPGMV
. | . .. ..|...|...| ||  |.|.... |||| . ...  .   .|..|||| |||||||.....|.|.      . ...  .||..| ||||.|
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgav

QTQAQFEFALTA
... |..| . .
pnpgqlrflyef
PTPc_DSPc_SM00012 420-521 3.8e-32 106.0 In-house 1-104 (105) alignment 
Range on Protein: 420-521
Range on HMM: 1-104/105.0
TVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRGRA--CPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFAL
||...|...||..|.| ...|.||. |.|.|. . ..   |.|||||.|||||||...||..| .. |. ||.||  .....|.||||||||..|. | .
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

TAVV
.|. 
rall
0038934 (Phosphotyrosine protein) phosphatases II 420-517 2.1e-12 42.6 In-house 78-170 (194) alignment 
Range on Protein: 420-517
Range on HMM: 78-170/194.0
TVTQFHFLTWPETGCPPSPKSLLEFRRKVNKSFRG-RACPIVVHCSDGVGRTGTYCLLDLVLTRMLkgvkelDIAATLEHIRDQRPGMVQTQAQFEFAL
   ... | .|. |..|| . ||.| . |.. ..    . ..|||  |.||||| .   |. .. .      .  . ....|. |||....| ..|  |
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdyleall
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 428-521 2.2e-06 21.4 In-house 236-335 (347) alignment 
Range on Protein: 428-521
Range on HMM: 236-335/347.0
TWPETGCPPSPKSLLEFRRKVNKS-------FRGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAV
|||    |   | .| . |   |          ..  |.|| |  |. |. |  |  ... ..|.| |  |  . . ..|||| |.      . .|. | 
twpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldg.ktpdcddlfkkmrdqragvftmsifytyairaa

V
.
l
subfamily_DSP23_pd Subfamily DSP23 433-513 7.3e-09 30.4 In-house 62-135 (148) alignment 
Range on Protein: 433-513
Range on HMM: 62-135/148.0
GCPPSPKSLLEFRRKVNKSfRGRACPIVVHCSDGVGRTGTYCLLDLVLTrmlkgvKELDIAATLEHIRDQRPGMVQTQAQF
 .||... . || | |...   ..  . |||  | |||||     ||        ..|  | ..  .| .||| |.|  | 
yhppaleqvvefvrvveea.eekneavsvhcllgrgrtgtmlacylvke......rklaaaeaiaevrrlrpgsvetveqe
PTEN_1 436-512 6.4e-06 21.1 In-house 108-181 (196) alignment 
Range on Protein: 436-512
Range on HMM: 108-181/196.0
PSPKSLLEFRRKVNKSFRGRAC--PIVVHCSDGVGRTGTyclldlVLTRMLKGVKELDIAATLEHIRDQR-PGMVQTQAQ
||  .|... ...  . . . .   ..|||  |.||.||      |.   |   . |.   .||..|..| ||....  |
pslselfdicksfiewllsdpngnvVlVHCkaGlgRsGt......vvaayLmykgkltadeAlelvrekRppgapnspsq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 451-519 2.6e-11 37.8 In-house 257-339 (350) alignment 
Range on Protein: 451-519
Range on HMM: 257-339/350.0
SFRGRACPIVVHCSDGVGRTGTYCLLDLVLT--RMLKGVK----ELD--------IAATLEHIRDQRPGMVQTQAQFEFALTA
.   |. ||.|||| |||||||.. || .|    .|. ..    .||        |  .. ..| ||  |||.  || |   |
ldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYea
subfamily_CG42327_pd Subfamily CG42327 453-519 3.8e-13 43.8 In-house 244-310 (319) alignment 
Range on Protein: 453-519
Range on HMM: 244-310/319.0
RGRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTA
| .  |.||||||||||||.    |. . .. .  . .||  .. ..| .|   |.|. |.||    
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 454-525 7.4e-14 46.3 In-house 226-296 (297) alignment 
Range on Protein: 454-525
Range on HMM: 226-296/297.0
GRACPIVVHCSDGVGRTGTYCLLDLVLTRMLKGvKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEEVN
 |  ...|||| ||||.|   | | .|... |. .  |.|| |...|.||. .|||  |||.  .||.. . 
prnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlkklk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 455-519 7.4e-08 26.1 In-house 264-339 (349) alignment 
Range on Protein: 455-519
Range on HMM: 264-339/349.0
RACPIVVHCSDGVGRTGTYCLLDLVLT--RML-KGVKEL--------DIAATLEHIRDQRPGMVQTQAQFEFALTA
.  ...|||| | ||||... |||.|    .| .    .         |  .. ..| ||  |||  ||| . . |
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyea
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 459-523 2.1e-09 31.7 In-house 1-64 (69) alignment 
Range on Protein: 459-523
Range on HMM: 1-64/69.0
IVVHCSDGVGRTGTYCLLDLVLTRmLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEE
.||||| | |||||.  . . ..| .|  | .||   . ..|  || ||  . .. |   |.|| 
mvvhcssgtgrtgtfiaimvemar.ikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 460-523 7.1e-09 29.9 In-house 1-63 (69) alignment 
Range on Protein: 460-523
Range on HMM: 1-63/69.0
VVHCSDGVGRTGTYCLLDLVLTRmLKGVKELDIAATLEHIRDQRPGMVQTQAQFEFALTAVVEE
||||| | |||||.  . . ..| .|  | .||   ....|  || ||  . .. |   |.|| 
vvhcssGtGrtGtfiaimvemar.ikseklvdifnnvqymrkcrpmmvmneneymfihdalvea