Gene SpurPTP-sf1-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP078_AA protein Get Run
SpurP078_AA_550-825 phosphatase_domain Get Run
SpurP078_AA_837-1111 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Herpes_LMP1 Herpesvirus latent membrane protein 1 (LMP1) 165-245 3.7e-06 12.4 Pfam-A 229-308 (381) alignment 
Range on Protein: 165-245
Range on HMM: 229-308/381.0
TASPGQTLSSDYVKAAVGRSFTGPWISHNSsDTSGPTLNNSSDTSGPTLNNSSDTSGPTLNNSSDTSGPTLNNSSDTSGPT
 |  |  | |. . |  |    ||    |. |  ||   . .|  ||   . .|  ||   . .| .||   ...|  || 
gagdgpplcsqnlgapgggpdngpqdpdnt.ddngpqdpdntddngpqdpdntddngpqdpdntddngpqdpdntddngph
fn3 Fibronectin type III domain 310-391 5.2e-08 26.1 Pfam-A 19-81 (85) alignment 
Range on Protein: 310-391
Range on HMM: 19-81/85.0
QWDPSDdTGEGPIVGYKIYVlsgS----NVvsekevqppsmvpmtdrsVSKRSTENAAEMvIYNVSGLEAGSTYSVQIAAIRDGIN
.|.|.. .|.|||.||.. .   .    .                   ..|. |  . ..  ....||..|..|.....|. .. .
sWsppk.dgggpitgYevey...rekggge..................ewkeftvprttt.svtltgLkpgteYefrVqavngage
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 546-837 1.6e-120 396.7 In-house 6-297 (297) alignment 
Range on Protein: 546-837
Range on HMM: 6-297/297.0
TRQPIPVAQFPAFVNKNRHTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDdkAYIASQGPNKT
 |.|||...|...|.||||| .|||||..||   |.|||||....||.|.|||||||||| ||||....| | |||.|||.....     .|..| |.|.
errpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

SMDDFWRMVWQENVTTIAMVTKLQEGDKiKCRQYWPDRKgqSVEFGTIKVELMELEPCTGGVARRMVMRKGE--ESRRVTQFHFTEWPDKGVPK--HTSS
...|||.||..|.|.||.|.....|.|| ||..||.|.   ...||.. |.|. .. ..|.. | ....||.    | | |..|.||||| |..  ..||
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

LLKFIKEVKADHGQYTH-PLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFT
|||.|.||. |..| .. ||..||.||||||||. .||||||.|||.  ||.|..|. .||.|||.|||.|||.|.| |||| ||  .| |.. .|.
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 547-864 2.5e-171 564.4 In-house 1-276 (392) alignment 
Range on Protein: 547-864
Range on HMM: 1-276/392.0
RQPIPVAQFPAFVNKNRHTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTS
|||||||||||||.||||.|||.|||||||||||||||||...|| |||||||||||||||||||||||||.|||.||||||||| .|||||||||| .|
rqpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MDDFWRMVWQENVTTIAMVTKLQEGDkikcrqywpdrkgqsvefgtikvelmelepctggvarrmvmrKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFI
.|||||||.|||||||||||||.|||                                          ||.. | |.||||||||||.||||||||||||
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

KEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTS
||||||.||||||||||||||||||||| ||||||||||.||||||||||||.|.||||||||.|||||||||||||||||||||||.|||||||||.||
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

GDGRGRSKMTKEFQTLKS
.||..|||..|||..||.
sdGdvrskqlkefrslka
subfamily_PTPRD_pd Subfamily PTPRD 547-902 1.8e-124 411.5 In-house 2-358 (564) alignment 
Range on Protein: 547-902
Range on HMM: 2-358/564.0
RQPIPVAQFPAFVNKNR--HTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNK
..|||||.....|.| .  . . |.||....  ..  . ..|....| .||||.||..||. ||.|. ..  . ||| |||.| ... .|||||.||| .
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

TSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRkGqSVEFGTIKVELMELEPCTGGVARRMVMR--KGEESRRVTQFHFTEWPDKGVPKHTSSL
....|||||||..|..|| |.|||.| .| || .|||.. | . ..| ..|.|.| |  .  . | . ..  | .||| |.|||||.|||.|||... ||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

LKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQD
|..|..|.| . . ..|...||||||||||.   ||...  .|  ..||....|...|..|..||||.|||.||. |.|| |   || ... ....||| 
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

LHTSGDGRGRSKMTKEFQTLKSLCPDpPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILD
|..  .. . ... .||| |..  .. ....  ..  | |. |||. | |.|...||.|.
LaeveedtemtgleleFqrLatakei.eleefavatkpknkkknrfsnilalescrvvls
subfamily_PTPRA_pd Subfamily PTPRA 547-857 1.5e-90 298.4 In-house 11-328 (330) alignment 
Range on Protein: 547-857
Range on HMM: 11-328/330.0
RQPIPVAQFPAFVNKN--RHTALFSEEFHDLPGPDIYPQ-TVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPN
  |.|| ..   ...     . || |||  ||  .|     .| .. | .|||. |||||| .|| | |.. ...||| |||.|  . . . .||.||| 
yfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk

KTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRkGqSVEFGTIKVELMELEPCTGGVARRMVMR------KGEESRRVTQFHFTEWPDKGVPK
. ...|||||.|. . .|| |.|.|.| .. || |||||  | .| .| |.||. . . .     | ....      . ..|| |.||||| ||| ||| 
eetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPf

HTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFT
..  .||..|.||. . |.. |...||||||||||    .|.|..  |  |.||||.|| ..|..|| ||||.||| ||| ..||  |. .| . |. . 
epiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssle

DHLQDLHTSGDGRGRSKMTK
 ||| |...  |  .  . .
khlqklynkitgtdkiglee
subfamily_PTPRB_pd Subfamily PTPRB 547-822 2.9e-90 297.3 In-house 4-283 (293) alignment 
Range on Protein: 547-822
Range on HMM: 4-283/293.0
RQPIPVAQFPAFVNKNR--HTALFSEEFHDLPGP-DIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPN
 .|| . .| ..|.|..    . ||||...|        ...|....| .||||.|||||| .||||. ..| ..||| ||.||| .   . .||.||| 
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

KTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKgQSVEFGTIKVELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLL
 ...||||||||......| |.|.| |. |.|| .|||. . ..| .| |||.|.. |  .  | | . ..|..|.|.|.|.||| ||| |||..|..||
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktll

KFIKEVKADH--GQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
.|...|.  .   . ..|...||||||||||.  ..| .. . ... .||.| .|...|..| ..|||..|| ||. .||.
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
0050432 (Phosphotyrosine protein) phosphatases II 547-828 1.4e-88 292.5 In-house 23-303 (308) alignment 
Range on Protein: 547-828
Range on HMM: 23-303/308.0
RQPIPVAQFPAFVNKNRHTALFSEEFHDLPGPDIYPQ-TVAREQINFKKNRYKNILPYDSARVKLevidDiPHSDYFNASYIPSF--DDDKAYIASQGPN
  ...| ..  ...|   . |..|||..|.   .... .||. . |..|||||.|||||. ||||    | ..||| ||||.. .  . ....|| ||| 
slklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPl

KTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKG-QSVEFGTIKVELMELEPCTGGVARRMVMRK--GEESRRVTQFHFTEWPDKGVPKHTS
.....|||||||..||..| |.|||.| ...|| ||||.  | .|.|.| ..|.|.. | . . . | . ...  ..|||.||.||.| ||| ||| ...
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspe

SLLKFIKEVKADHGQytHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRN
.||.|...|.  ...  .| ..||||||||||..  .| .. . .....||||. |  .|..||.|||| ||| |.| |.|| |... 
illdflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 547-860 1.7e-87 288.5 In-house 2-319 (319) alignment 
Range on Protein: 547-860
Range on HMM: 2-319/319.0
RQPIPVAQFPAFVNKNRHT--ALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNK
...|.|...   ... ..|   |. .||..| ...    . | ...| |||||.|||.|| .||.|  .|... ||| |||.| .... ...|| |.| .
dteievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle

TSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDrkGQSVEFGTIKVELMELEPCTGGVARRMVMRKGE---ESRRVTQFHFTEWPDKGVPKHTSS
. ..|||||||.|.. .. |.|||.|  |.|...|||.   . .|.| . |.| | |   . . |.. ..|     |.|.|..|..|||||..||... |
ntiedfWrmvWeeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

LLKFIKEVKAD-HGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHL
||...|...   ...   |...||||||||||    .| .. . |.  ..|||..| ..| .|. |||..||| ||| |.|| .   .| | | .. | |
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

QDLHTSGDGRGRSKMTKEFQ
..|     . | ... .|||
kqlaekvadtgetglerefq
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 547-841 1.7e-84 278.5 In-house 3-296 (315) alignment 
Range on Protein: 547-841
Range on HMM: 3-296/315.0
RQPIPVAQFPAFVNKNRHT--ALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNK
.||||. |. ..| ... .    | ...  .|| ...|  ||..  | .|||| ||..|| .||.| ...  ||||| ||..|. ..  . |||.|||| 
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

TSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRkgqSVEFGTIKVELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLK
.|..||||.|..|....| |.|.| ||.| |. .||||.    | .| | | ... |  |    | . .  |.. | | |.|.| ||| ||||.| .|..
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmn

FIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQ
.|. ||  | .   ....||||||||||   ..|.|. .|.  ...||.||.|..||.|  |||. ||| ||| |.|| ..  .| |    . .. .
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 547-629 1.6e-14 48.1 In-house 3-85 (440) alignment 
Range on Protein: 547-629
Range on HMM: 3-85/440.0
RQPIPVAQFPAFVNKNRHTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPS
..|| ||.|  .|..|| .  | .|.  ||     |  .|    |  ||||.||| || .|| || .  .|.||| ||||| .
qrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 548-862 1.3e-197 650.0 In-house 1-315 (315) alignment 
Range on Protein: 548-862
Range on HMM: 1-315/315.0
QPIPVAQFPAFVNKNRHTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSM
|||||||||||||||||||||||||||||.||||.|.||||.|||||||||||||.||||||||||||.|.|||.|||||.|.||||||||||||.|.|.
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

DDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIK
|||||||.||.||||.||||.||||||||||||||||..|||||.|||||..||..|.||||..|.||.||||.||||.|||||||||.|.||||||.||
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklik

EVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSG
|||||.|.....|..||||||||||||.|||.|||..||||.|||||||.|.|.||||.|||.|.|||||.|||||||||||||.||||||||||||||.
evkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsv

DGRGRSKMTKEFQTL
||.|||||||||.||
dgsgrskmtkefetl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 549-1001 2.5e-290 957.9 In-house 1-453 (515) alignment 
Range on Protein: 549-1001
Range on HMM: 1-453/515.0
PIPVAQFPAFVNKNRHTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMD
|.|.|||||||||||||.||||||||||||.|||||||.|.||||||||||||||||.|||||||.| ||||||||||||||| ||||||||||||.|.|
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKE
||||.|.|||||||||||||.||||||| .||||. |.||.||.|||||. || ||||. |.. . ||..|| |||||||||||||||||||||||.|||
dfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklike

VKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSGD
|||||||||||||||||||||||||| |||||||||| ||||||||||||.||||||.||||||||||||||||||||||||||||||||||||||.|||
vkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd

GRGRSKMTKEFQTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIV
||||||||||||||||||||||||||||||| ||.|||||||||||||||||||||||||||||||||.||||||||||||.||||||||||| ||||||
grgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspdhdyinasqmkgihctfmttqmplpttvsdfwsmvlnnkpstiv

MLNDKSQNDKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRNSKT
|||||||||||||||||.|.| |||||||.|||||.|||||||.|..||||| 
mlndksqndkscaqywpdansvqfgsysvstlstssdgdmtirqlqvtrnskr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 549-844 1.2e-83 275.8 In-house 3-303 (305) alignment 
Range on Protein: 549-844
Range on HMM: 3-303/305.0
PIPVAQFPAFVNKNRHTA--LFSEEFHDLPGPdIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTS
.| .... |.....| .    . .... |.     .  | ... | .|||.|.| ..|  |..|   .. ..||| ||||. ...  |.||..||| |. 
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

MDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELEPCTGGVARRMVMRK---GEESRRVTQFHFTEWPDKGVPKHTSSLL
..||||....| |.|| |.|||.||.| |||||||..|....||| ..||| . .  .. . |.. . .    .||| |.|...|.|||.|||. ..|||
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

KFIKEVKADHGQYTH-PLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQD
..||.|. |. .    ||..|||||||||||  ..|  . ..|.  .||||. . ..|.||..||||..|| |.. |. | .   .| | .  .. ... 
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

LH
|.
lk
subfamily_PTPRG_pd Subfamily PTPRG 550-828 2.3e-75 248.9 In-house 1-291 (563) alignment 
Range on Protein: 550-828
Range on HMM: 1-291/563.0
IPVAQFPAFVNKNRHT--ALFSEEFHDLP---GPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHS-DYFNASYIPSFDDDKAYIASQGPN
.|| .|   | .        |||||..|     ..  . . .... | .|||| ||..||..||||. . .. .. || ||.||  .   ||.||.||| 
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

KTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDrkGQSVEFGTIKVELMELEPCTGGVARRMVMRK-----G---EESRRVTQFHFTEWPDKGV
|. .||||||.|..||..| |.|.|.|  . || .|||    .|...|...| |.| |  .    |..|...     .   .. ..|.|.|.|.|||.||
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgv

PKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRN
|.|.   |.|.|  .| . . . |...||||||||||.   .|...   ..  .|.||.|.  .| .|...|||.||| |.. |.|| .. ..
PehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 550-825 2.6e-65 215.2 In-house 2-279 (287) alignment 
Range on Protein: 550-825
Range on HMM: 2-279/287.0
IPVAQFPAFVNKNRHT--ALFSEEFHDLPGPDIYPQ--TVAREQINFKKNRYKNILPYDSARVKLEviddIPHSDYFNASYIPSFDDDKAYIASQGPNKT
||| .|  ||.|....    |.. |  |   .  ..  |..  . | .|||...||..|  || |.      | || ||..| .. ..||.|....|   
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

SMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGqsVEFGTIKVELMELEPCTGGVARRMVMRK---GEESRRVTQFHFTEWPDKG-VPKHTSS
 . .||......|||.| |.....| |. .| ||||. |   | .|  ..||.. |  .| . |.. ...    .. ..|.|...|.|...| |... ..
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLL
|| . . .|... .   ....|||..|||...  ...  . ..|.   .|||. . ..|...| .||| ||| ||. .||| | 
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 550-823 8.3e-65 213.5 In-house 2-282 (290) alignment 
Range on Protein: 550-823
Range on HMM: 2-282/290.0
IPVAQFPAFVNKNR--HTALFSEEFHDLP-GPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPH--SDYFNASYIPSFDDDKAYIASQGPNK
||| .|  || ...   .  | ..|. |  |   .  ||.  . | ..||..||..||  |. |  | . .    .| ||.||  . ..|.||| ||| .
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

TSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSveFGTIKVELMELEPCTGGVARRMVMRKGEE---SRRVTQFHFTEWPDKG-VPKHTS
  . |||...|||.|| | |.|. .| .| ||.|||||.. ..  .| ....|.. | ... . |.. ... ..   .. |||...| |...| |.....
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

SLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLED
.|| . . .|  . .  .....|||..|||..|  ...  . ..| .  .|||. . ..|...| .|||..|| .|.  ||. 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
0051299 (Phosphotyrosine protein) phosphatases II 552-822 2.2e-89 295.0 In-house 7-284 (288) alignment 
Range on Protein: 552-822
Range on HMM: 7-284/288.0
VAQFPAFVNK--NRHTALFSEEFHDLPGPD-IYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMD
| ..  .|.|   ...... |||..|.     .....|. . |..||||..|||||. |||| |.|....||| |||||. .. ....|| ||| .....
veellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntve

DFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDrkGQSVEFGTIKVELMELEPCTGGVARRMVMR------KGEESRRVTQFHFTEWPDKGVPKHTSSL
|||||||..||..| |.|||.| ...|| ||||.  |.|...| |.|.|.. | . . . | . ..      ...|||.||.||.| ||| ||| ....|
dFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspell

LKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
|.|...|.  . .  .| ..||||||||||..  .| .. . .....|||...|  .|..||.|||| ||| |.| |.||
ldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_PTPN9_pd Subfamily PTPN9 553-822 1.7e-73 242.3 In-house 4-288 (297) alignment 
Range on Protein: 553-822
Range on HMM: 4-288/297.0
AQFPAFVNKNRHTALfSEEFHDLPGPDI-YPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFW
 .. |.|.....  | |.|. ..    .    .... . | .||||...| ||..||.|. .|. ..||| ||...  .   ||.|| ||| |  ..|||
eelvayvkekgkrGl.skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfW

RMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELEPCTGGVARRMVMR--KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEV
||||...| .| |.|.. |  ..||.||||. ...| ||| ..|. .| |     . | ....  | ||||.|| | |. ||| |||. ..|||.....|
rmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekv

KADHGQYT-------------HPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
.   .. .              |...|||||.||||  ...|  ... ... .|||.. |  .|..| ...||.|||.| | ||||
rekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
0040438 (Phosphotyrosine protein) phosphatases II 555-861 8.6e-89 293.2 In-house 8-313 (317) alignment 
Range on Protein: 555-861
Range on HMM: 8-313/317.0
FPAFVNKNRHtALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMV
.  ...|. .  ...|||.||.  .... .||. . | .||||..|||||. |||| ... ...||| ||||.. ..  ...|| ||| . ...||||||
alldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmv

WQENVTTIAMVTKLQEGDKIKCRQYWPDrkGQSVEFGTIKVELMELEPCTGGVARRMVMR--KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD
|...||.| |.|.| | ...|| ||||.  |.....|...|.|.. | . | . |.. .   ...|||.||.||.| ||| |||.....||.|...|.. 
weqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

HGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSGDGRGR
  .  .|...||||||||||..  .. .. . .... |||.. |  .|..||..||| ||| |.| |.|| |....||.|. ..  .|. |..   . . 
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddv

SKMTKEFQT
. ..||...
klkekelkl
0039614 (Phosphotyrosine protein) phosphatases II 555-829 3.1e-81 268.4 In-house 21-294 (297) alignment 
Range on Protein: 555-829
Range on HMM: 21-294/297.0
FPAFVNKNRHTALFSEEFHDLPGPDIyPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDI-PHSDYFNASYIPSFDD-DKAYIASQGPNKTSMDDFWR
.  ...|   . |. .|| .|.   . ....|. . | .|||||.|||||. |||| ..|.  ..||| ||||.. .|  ....||.|||.. ...||||
lllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

MVWQENVTTIAMVTKLQEGDKiKCRQYWPDRKGqsvEFGTIKVELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD
|||...||.| |.||| | .. || ||||.. |   ..|...|.|.. | . | . | . .....||| ||.|..| ||| ||| ....||.|...|.  
mvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrea

HGQ--YTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNT
. .    .| ..||||||||||..  .. .. . .... |||.. |  .|..||..||| .|| |.| |.|| |....|
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_Ptp69D_pd Subfamily Ptp69D 557-843 1.2e-79 262.6 In-house 12-305 (307) alignment 
Range on Protein: 557-843
Range on HMM: 12-305/307.0
AFVNKNRHT-ALFSEEFHDLPGPDIYPQTV-AREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMV
|.....|.|  .. .|.. |.   |  .|. . .. |  ||||..| ..|. ||||..|    .||| |||.| .... | .||.|.|  . ..|||||.
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

WQENVTTIAMVTKLQEGDKIKCRQYWPDRkgQSVEFGTIKVELMELEPCTGGVARRMVMRKG-------EESRRVTQFHFTEWPDKGVPKHTSSLLKFIK
.. .||.| |...|.| .. || .|||.   . |..| | |.|.. | ..  . | . . |        |.||.|.|.|.|.|.|  ||... .|||.|.
aeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

EVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDL
.|.  . .   |...||||||||.|.. ..||.. . |    ||.|..| ..|..|. .||  ||| |.| |.|.   . .| . | .. |... |
qvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
0047943 (Phosphotyrosine protein) phosphatases II 558-822 3.7e-83 274.4 In-house 4-270 (273) alignment 
Range on Protein: 558-822
Range on HMM: 4-270/273.0
FVNKNRHTALFSEEFHDLPGPD-IYPQTVAREQINFKKNRYKNILPYDSARVKLevidDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQ
...|  ...|. |||..|.    ... .||. . |..|||||.|||||. ||||    . ..||| ||||.. ..  ...|| ||| . ...|||||||.
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

ENVTTIAMVTKLQEGDKIKCRQYWPDRKGQ-SVEFGTIKVELMELEPCTGGVARRMVMRK--GEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH
.||..| |.|.|.| ...|| ||||.  |. |...| ..|.|.. | . . . | . ...   .||| ||.||.|.||| ||| ...|||.||..|.  .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

GQ--YTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
 .    .| ..||||||||||..  .| .. . .....|||.. |  .|..||.|||| ||| |.| |.||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 559-829 1.8e-86 285.1 In-house 20-295 (298) alignment 
Range on Protein: 559-829
Range on HMM: 20-295/298.0
VNKNRHTALFSEEFHDLPGPDI----YPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMV
|.|. . . ...||. |           ..|||.. | ||||| .|...||.|| || .|.  .||| |||.. .... .|.||.|.| .... ||||||
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WQENVTTIAMVTKLQEGDKIKCRQYWPDRKgqSVEFGTIKVELMELEPCTGGVARRMVMRKG--EESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD
..|...|| |.|.|.| ||.|. .||||..  . ..|.|.|.|.. |  .  . |.. . |   |..|.| |.|||.|||||||....|.|.....|.| 
teedigtiVmltnleeldktkyhkywPdeg..ketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvras

HGQYT-HPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNT
. |   .|.|..|||||||.|    ||||. ..|. ..||||. |  .|.||| .|||.|||.||| |||| |   |.
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 560-836 1.6e-57 189.9 In-house 15-291 (439) alignment 
Range on Protein: 560-836
Range on HMM: 15-291/439.0
NKNRHtALFSEEFHDLP--GPD-IYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQ
.||..  .|.|.|. .    ||     ..| .. .  |||||.. ..| .|| |. |  .||| |.|| ||  . ||| |||.|||.| . |||||.|..
dknkq.eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

ENVTTIAMVTKLQEGDKikcrqYWPDRkgQSVEFGTIKVEL---MELEPCTGGVARRM-VMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVK-A
....|| |.|.| |  |     |||    . | .| | |     .||   .    . .    ..|  | | |||.. |||| || ..| .|.|.. .. |
kktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsa

DHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHF
.  . . |...|||||||||| . ..|  . . |    ||.   |. .|..|  |||.  || ||| |||||. . .. . . .|
ndkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
0045450 (Phosphotyrosine protein) phosphatases II 561-822 1.4e-80 266.6 In-house 22-302 (307) alignment 
Range on Protein: 561-822
Range on HMM: 22-302/307.0
KNRHTALFSEEFHDLPGPD---IYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDI-PHSDYFNASYI--------PSFDDDKAYIASQGPNKTSMD
.  . ... .||..|.      ... ..|. . | .|||||.|||||. |||| ..|.  ..|||.||||.        ...| ....|| ||| . ...
lldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetve

DFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRkGQSVEFGTIKVELMELEPCTGGVARRMVMR---KGEESRRVTQFHFTEWPDKGVPKHTSSLLKF
|||||.|...||.| |.|.| | ...|| |||||  |.....| ..|.|.. | . | . |.. .    . .|||.||.||.|.||| |||.....||.|
dFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldf

IKEVKADHGQ--YTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRM---VDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
|.||.. ...    .| ..||||||||||..  .. .  . ... .   ||... |  .|..|| .||..||| |.| |.||
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_CG7180_pd Subfamily CG7180 561-825 2.6e-57 188.7 In-house 12-291 (296) alignment 
Range on Protein: 561-825
Range on HMM: 12-291/296.0
KNRHTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVT
.... ...  |..  |  .|     . .. | .|||. ...||| .|| || .|   .||| ||.|. ||  .|.||  ..| | ..|.|||.|..|.. 
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIAMVTKLQEGDKiKCRQYWPDRKgqSVEFGTIKVELMELEPCTGGVARRMVMRKG------------EESRRVTQFHFTEWPD-KGVPKHTSSLLKFIK
.. ..||  .  | .. .||| .     ..| | ||..| .  .  . | . . |              | | |..|..|||.  . ||  |..|.....
avvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

EVKADHGQY-----THPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLL
 |.   ..      . |.....| |..|.||  .||  .  ....  ||||..|  .|..|| .|.. |.| .||  .|| .|
rvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 562-821 6.5e-86 282.9 In-house 17-276 (288) alignment 
Range on Protein: 562-821
Range on HMM: 17-276/288.0
NRHTALFSEEFHDLPG-PDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVT
 |  . ||||.. |.       .|..|.  | |||||.||||||  ||||.  .. . .|| ||||| . . .|.|||.|||.  ...|||..|......
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

TIAMVTKLQEGDKIKCRQYWPDRkGQSVEFGTIKVELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPL
||.|.|.| ||.| || .||||  .. ...| ..|.|.| .  .  | |.. . | .. ...||.... |||.|||. .  ||.... ||  . . | |.
tivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpi

IIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVL
|.||||||||||.  ..| .. . ... ..||...|...|..|. .|||..|| ||| ..|
ivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
0036941 (Phosphotyrosine protein) phosphatases II 562-835 8.1e-84 276.7 In-house 10-288 (297) alignment 
Range on Protein: 562-835
Range on HMM: 10-288/297.0
NRHTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLeviDDiPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTT
.  . | .|  . ||   ... .||. . | .|||||.|||||. ||||   || ..|||.||||.. .| ....|| ||| .....|||||||..|||.
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELEP--CTGGVARRMVMRK--GEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--
| |.|.| | ...|| ||||. .|.|...| ..|.|.. |   ... . | . . .  ..|||.||.||.| ||| ||| ...|||.||..|.  . .  
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

YTHPLIIHCSAGVGRTGVVTSIDSVVAHAK---RTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIH
  .| ..||||||||.|..  .| ..   .   ... ||....|  .|..|| .||| ||| |.| |.|| |....| .|.. 
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 562-859 3.8e-75 248.0 In-house 19-323 (325) alignment 
Range on Protein: 562-859
Range on HMM: 19-323/325.0
NRHTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMV--WQenv
 .    |. ||  ||  |   ..||    | .|||.||....| .|| ||  .| |.|||.||||. .. . . ..|.| |. ....|.||.|  |.   
aqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...

TTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELEPCTGGVARRMVMRK--GEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYT
... .|.   ...| .| .|||.. |.|..||...|.|. .|  .  | |.. ...  . |.| | ||..  |.| ||.|. ..|. ... ||| . . |
csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

H------PLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSGDGRG
       |...|||||||||||  |. |..|.      ||.|.|| ..|..|| ||.| .|| .|| |. | ..  || .||  |  .|  |.       
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltq

RSKMTKEF
. .. |||
klniekef
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 562-833 3.2e-61 201.7 In-house 5-275 (283) alignment 
Range on Protein: 562-833
Range on HMM: 5-275/283.0
NRHTALFSEEFHDLPGPDIyPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYIP---SFDDDKAYIASQGPNKTSMDDFWRMVWQEN
.    || | .. |  ||  . ..|  . | .|||...|.|.|  ||.|.        || ||..||   | ..|| ||..|.| .  . |||.||..|.
vnnnklfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

VTTIAMVTKLQEGDKIKCRQYWPDRkGqSVEFGTIKVELMELEPCTGGVARRMVMRKG---EESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ
.|.| |.|||||. .||| |||| | | |...|   | | .       . . ...|.    ...  .. . . .| . |      ||.|| | .     .
itaivmltklqedlrikCsqyWPkr.G.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes

YTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPV
   |...|||.|.|||.|  .. . | .|.   .||||. |..||..|. .|||..|| ... .|||. |  .| |  
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaa
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 562-823 2.9e-56 185.4 In-house 11-292 (301) alignment 
Range on Protein: 562-823
Range on HMM: 11-292/301.0
NRHTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVID--DIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENV
. |.  |.|....|   .  . ||  .. | . ||.||| .||  |. |.     |. . .| ||||| .. . |..||.||| |  . ||||..||| .
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELE--P--------------C-TGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSL
..| |||.|.|| | ||.||||. . .| |||...|.|..    |                 | . |.. ...  .|. |.|.. |.||. || .     
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LKFIKEV-KADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLED
|. | .| .. .     |...|||..|.|.||  |..  .  .|.   ||||. .  .|...| .|.| ||| .|| .. . 
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
0043336 (Phosphotyrosine protein) phosphatases II 563-822 2e-81 268.8 In-house 17-275 (278) alignment 
Range on Protein: 563-822
Range on HMM: 17-275/278.0
RHTALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTI
   .|...||..|.  .......|. . |..|||||.|||||. ||||....  ..||| ||||.. ..  ...||.|||.. ...|||||||...||||
nlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

AMVTKLQEGDKIKCRQYWPdrkGQSVEFGTIKVELMELEPCTGGVARRMVMR--KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPL
 |.|.| | ...|| ||||   |.|...|...|.|.. | . . . | . .   .  ||| ||..|.. ||| ||| ..|.||.|.|.|.       .|.
vmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

IIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
..||||||||||..  .. .. ...... ||... |  .|..|| .|||..|| |.| |.||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPN6_pd Subfamily PTPN6 564-821 3e-74 244.8 In-house 24-294 (306) alignment 
Range on Protein: 564-821
Range on HMM: 24-294/306.0
HTALFSEEFHDLP---GPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEvIDDIPHSDYFNASYIP--SFDDDKAYIASQGPNKTSMDDFWRMVWQEN
. | |.|||..|      . . .. .. . | .|||||||||.| .||.|.  ...| ||| ||.||   . . ||.|||.||  .| . ||||||||||
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

VTTIAMVTKLQEGDKIKCRQYWPDRKGQSVeFGTIKVELMELEPCTGGVARRMVMR---KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ
 . | |.||  |  | || .|||| . ..  .|.|.|. .. .  .  . |....    |..|.|.| |.||..|||.||||... .|.|...|.. . .
srvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqee

YT----HPLIIHCSAGVGRTGVVTSIDSVVAHAKRTR---MVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVL
 .     |...|||||.|||| .  || ..   ...     .|. ..|  .|. |  .|||..|| |.| |. 
leeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 565-862 3.6e-93 307.1 In-house 19-318 (318) alignment 
Range on Protein: 565-862
Range on HMM: 19-318/318.0
TALFSEEFHDL-PGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIA
. |.|||.. | . ..   .. . |..| .|||| |||.||..||||. ... . ||| ||.||. .  .|||||.|.|    ..|||||||. | ..| 
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MVTKLQEGDKIKCRQYWPDRkgQSVEFGTIKVELMELEPCTGGVARRMVMRKG--EESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH-GQYTHPL
|.|...|  |.|. .|||..  .| ..|...|||.|   ..  | |.. ...   |||| | |.|.|.|||.|||....|||.....|.. .  . ..|.
mltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

IIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSGDGRGRSKMTKEFQ
..|||||||||||   .|... ..|   .||||..|...|..|. ||||..|| ||| ..|| |   .| .   ........|. .    |...|  |||
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq

TL
 |
rl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 565-824 3.2e-81 267.5 In-house 14-276 (281) alignment 
Range on Protein: 565-824
Range on HMM: 14-276/281.0
TALFSEEFHDLPGPDIY-PQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIA
.| | ||...|   ..  . | .... | .||||.||  || .|||..  ..  ..|| ||...|.....|.|||.|||  .|...||.|||...|..|.
naGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MVTKLQEGDKIKCRQYWPDRKgQSVEFGTIKVELMELEPCTGGVARRMVM-RKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYT-HPLI
|||.  |..|.|| .|||| . .....|...|. .. |  .  . |.. . |.. |.|.|.|...| |||.|||. |. ||.| |||.  . . | .||.
mvtreieagklkChrYWPddn.selkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplv

IHCSAGVGRTGVVTSIDSVVAHAKR-TRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDL
|||||||||||.  ..| .| .... ....|| . |...|..| .||||  ||.|.| |||. |
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 565-641 5.3e-11 36.6 In-house 22-95 (95) alignment 
Range on Protein: 565-641
Range on HMM: 22-95/95.0
TALFSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDiphSDYFNASYIPSFDDDKAYIASQG
   | .||. ..     | ||   . |  |||. ||.|||..|| |    |   ||| || ..  .   ..|||.||
dqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 567-821 1.3e-69 229.3 In-house 6-265 (274) alignment 
Range on Protein: 567-821
Range on HMM: 6-265/274.0
LFSEEFHDLPGPDiyPQTVAREQINFKKNRYKNILPYDSARVKLEVID-DIPHSDYFNASYIPSFDD-DKAYIASQGPNKTSMDDFWRMVWQENVTTIAM
 . .|| .||     .|   .   . .|||||.||| . .|| ||  . . . |.| || ||  .|  .|||.| |||  . ..|||||..||.|. | |
dlekeflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

VTKLQEGDKIKCRQYWPDRKGQ--SVEFGTIKVELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTH---P
.|||.| .. || .|.||...   | ..| ....  .   . .   |..|... |..|.|. . .|.|||. .|.....||....||. .. . ..   |
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklap

LIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVL
 ..|||||.||||. ..|.  | . ... .|||.. |.|.|..|  ||||.||| .|. |. 
vvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_PTPRK_pd Subfamily PTPRK 568-861 2.6e-83 274.4 In-house 24-314 (314) alignment 
Range on Protein: 568-861
Range on HMM: 24-314/314.0
FSEEFHDLPGPdiypQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTK
| ||.  |.        .|... | .|||...||.|| .||.| .||. |.||| ||..| |.   .|.|. ||| .  . ||||.|..|| ..| |.|.
fkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlte

LQEGDKIKCRQYWPDRKGQsveFGTIKVELMELEPCTGGVARRMVMRK----GEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIH
|.|  ..|| .|||.   .   .| |||||.| |. .  |.| . ..|     || | | ||.|. ||| .||..  .|||....||. . .   ....|
lvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvh

CSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSGDGRGRSKMTKEFQT
|||| ||||.   ||.|.  ..| ..||||| | ..|.... ||.|.||| ||| ..||  |  .| ||| .|     .          |.. .||||
CsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefqt
0045098 (Phosphotyrosine protein) phosphatases II 568-826 5e-71 234.6 In-house 10-274 (278) alignment 
Range on Protein: 568-826
Range on HMM: 10-274/278.0
FSEEFHDLPGPDIYPQTVAREQINFKKNRYKNILPYDSARVKleviddiphsDYFNASYIPSFddDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTK
..| .. |. ....  |.|    |..|||||.|||||. |||          || |||||...  .|..|| ||| .. ..|||||.|....|.| |.|.
llefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlte

LQEGDKIKCRQYWPDrkGQSVEFGTIKVELMELEPCTGGVARRMVMR------KGEESRRVTQFHFTEWPDKGVPKHT--SSLLKFIKEVKADHGQ----
|.|....|| ||||.  |.|...| ..|.|.. | .   . |.. ..      .. ||| ||..|.. ||| ||| ..  .|.|........ . .    
lvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------YTHPLIIHCSAGVGRTGVVTSIDSVVAHAkrTRMVDVFNFVTNMRQKRPY-MVQTQEQYAFIYGAVLEDLLW
           .| ..||||||||||..  .. .  .    . ||... |. .|..||. .||..||| |.| ..|| ||.
llsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 568-821 5.6e-45 148.2 In-house 13-266 (281) alignment 
Range on Protein: 568-821
Range on HMM: 13-266/281.0
FSEEFHDLPG-PDIYPQTVAREQINFKKNRYKNILPYDSARVKLEV-IDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMV
| .|| .||| |     ||  . .| ||||| ||   | .||.|.| . .   .||  | || |    . || .|||.| .  |||||.|||| |.| |.
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqyTHPLIIHCS
 .. | .. || .|.|      ..|  . |.  .       |. |. .    |.| .|.. . ||||  ||. .  .|| .....|     . | .||||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcs

AGVGRTGVVTSIDSVVAHA-KRTRMVDVFNFVTNMRQ-KRPYMVQTQEQYAFIYGAVL
|||||.| . ...  .     .  . |. . |. .|   |   ||| .|| .|.  .|
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_CG42327_pd Subfamily CG42327 569-752 6.4e-27 89.0 In-house 8-193 (319) alignment 
Range on Protein: 569-752
Range on HMM: 8-193/319.0
SEEFHDLPgpDIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDK-AYIASQGPNKTSMDDFWRMVWQENVTTIAMVTK
 |||.|||   .  .. .      .|.|. |..|   .|| |. | | ... |..|||.  .|| .  |||.| . . |  ||||.||. .  .|  .|.
aeefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LQEGDKIKCRQYWPDRKGQS--VEFGTIKVELMELEPCTGGVARRMVMRK--GEESRRVTQFHFtEWPDKGVPKHTSSLLKFIKEVKAD
|.|    .| .|.| ...      .| |.| | . |     .   .....  .|||| .| . . .|.. .|| . ..|.  . ||.. 
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
0046845 (Phosphotyrosine protein) phosphatases II 570-830 6.1e-86 283.6 In-house 4-280 (284) alignment 
Range on Protein: 570-830
Range on HMM: 4-280/284.0
EEFHDLPGPDIY---PQTVAREQINFKKNRYKNILPYDSARVKLEVIDD-IPHSDYFNASYIPSF-----DDDKAYIASQGPNKTSMDDFWRMVWQENVT
|||. |.   ..   . .||. . |..|||||.|||||. |||| ..|. ...|||.||||.. .     .  |..|| ||| .....|||||||..||.
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

TIAMVTKLQEGDKIKCRQYWPDRkGQSVEFGTIKVELMELEPCTGGVARRMVMRK---GEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG--Q
.| |.|.| | ...|| ||||.  |.....| ..|.|.. | . . . |.. ...   ..|||.||.||.|.||| ||| ....||.|...|.  .    
vIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

YTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTR---MVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTL
. .| ..||||||||||..  .| .  . ....   .|||.. |  .|..||.|||| ||| |.| |.|| |....||
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_PTPN12_pd Subfamily PTPN12 579-822 2.9e-83 274.1 In-house 28-275 (290) alignment 
Range on Protein: 579-822
Range on HMM: 28-275/290.0
DIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQ
..|........ | ||||||.||||| .||.|. |.. ..||| ||..|   .....|||.|||  . .||||||.|. ||. . |. .. | .|.||..
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPDRKGQSVEFGTIKVELMELEPCT-GGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSI
|||.......|||...|.|.| . .. . . | . ... .|||.|.|||.|.|||.|||. ..|||..|..|.  . .  .||..||||||||||.. .|
YWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DSVVAHAKRTRM---VDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
| |    |. ..   .|||. |...|..|. .|||.||| ..| ||.|
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 579-846 9e-72 237.1 In-house 49-313 (319) alignment 
Range on Protein: 579-846
Range on HMM: 49-313/319.0
DIYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTklqegdKIKCRQ
.   || |  . |  |||. |||..| ..|||| .. .  ||| |||..  .   . |||.||| . ...|||||.|. |..|| ..|      | || |
nladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPDRKGQSVEFGTIKVELMElePCTGGVARRMVMRK---GEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--YTHPLIIHCSAGVGRTGV
||| .  .  | . .||...|   .   | | . . .    .. |..|||||  |||.|||...| |....| |.  . .    .....|||||||||||
ywplkivikeerfkvkvdsve..etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGv

VTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTS
   .| ..   |. ..|||.||| ..||.|. .||   || ||| |.||. |. .. . .  |  .|..| . 
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsnk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 580-673 1e-07 25.8 In-house 23-115 (332) alignment 
Range on Protein: 580-673
Range on HMM: 23-115/332.0
IYPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDipHSDYFNASYIPSFDDDKAYIASQGPNK-TSMDDFWRMVWQENVTTIAMVTKLQEGDK
 ||.|  .   |.  ||   .  .| .||.|   |   . |..|||..  .    ||| .| | .  .   ||||| . . . | ..  ..| .|
typntydkflnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqk
subfamily_PTPN1_pd Subfamily PTPN1 581-823 1.9e-56 185.9 In-house 22-270 (290) alignment 
Range on Protein: 581-823
Range on HMM: 22-270/290.0
YPQTVAREQINFKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYW
.|...|... | ..|||... ||| .|.|||  |     || ||| .   . .. || .|||    .| ||.|||...  .. |. |. | ..||| |||
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PDRK-GQSVEFG--TIKVELMELEPCTGGVARRMVMRK--GEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH--GQYTHPLIIHCSAGVGRTGV
|  .  .....   ..||.|.. |     . | . . .   .|.| ...||.| ||| |||.  ...|||. .|.      .   | .||||||.||.| 
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

VTSIDSVVAHAKRTRM---VDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLED
.. .|..... ...     ||. . . ..|. |  ..||..|  | | |.|| 
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
DSPc_SM00195 582-822 8.4e-84 276.3 In-house 17-260 (263) alignment 
Range on Protein: 582-822
Range on HMM: 17-260/263.0
PQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
. | |... | .|||||||||||. ||||. ... ..||| ||.||   . .|.||| ||| .. ..|||||||.|.|..|.|.|. .| .|.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

DRKGQSVEFGTIKVELMELEPCT-GGVARRMVMRKGE--ESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSID
. .|.. .||.|.|.|.| | .    . | . ..| .  |.|.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||.. .||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
... . ... .||.|. |...|..|| ||||.|||.||| |.||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 582-822 8.4e-84 276.3 In-house 17-260 (263) alignment 
Range on Protein: 582-822
Range on HMM: 17-260/263.0
PQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
. | |... | .|||||||||||. ||||. ... ..||| ||.||   . .|.||| ||| .. ..|||||||.|.|..|.|.|. .| .|.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

DRKGQSVEFGTIKVELMELEPCT-GGVARRMVMRKGE--ESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSID
. .|.. .||.|.|.|.| | .    . | . ..| .  |.|.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||.. .||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
... . ... .||.|. |...|..|| ||||.|||.||| |.||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0040439 (Phosphotyrosine protein) phosphatases II 582-822 1.5e-75 249.3 In-house 2-244 (249) alignment 
Range on Protein: 582-822
Range on HMM: 2-244/249.0
PQTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
. .||. . | .||||..|||||. ||||..... ..||| |||||. ..  ...|| ||| . ...|||||.|....|.| |.|.|.| ...|| ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DrkGQSVEFGTIKVELMELEPCTGGVARRMVMR--KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--YTHPLIIHCSAGVGRTGVVTSI
.  |.|.|.|...|.|.. | . . . | . .   .  |||.|.....| ||| |||.....||.||..|.  . .    .|...||||||||||..  .
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
. .. . .... ||... |  .|..||..||..||| |.| |.||
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 582-825 4e-17 56.8 In-house 36-280 (303) alignment 
Range on Protein: 582-825
Range on HMM: 36-280/303.0
PQTVAREQI--NFKKNRYKNILPYDSARVKLEviddipHSDYFNASYIpSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQY
| .|...|.  |..|||. ...  | ..|||        | |  |||.  .| .|  | .| |   .  |||.|. ...|  . ..    | ||.     
ppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

WPDRKG-QSVEFGTIKV-ELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKH-TSSLLKFIKEVKADHGQYT--HPLIIHCSAGVGRTGVV
.|  .     |  .|.| |. ..|   | | . . . .|.    .   |. .|| . .| . .. ..| | ....   .|.  .| .    .|.||.|  
fprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtf

TSIDSV--VAHAKrTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLL
. ...     |..    .|. . . |.|. | . ||   |....|  . | .|
alfetahlslhse.qasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 583-846 6.4e-71 234.1 In-house 17-277 (284) alignment 
Range on Protein: 583-846
Range on HMM: 17-277/284.0
QTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTklqegdKIKCRQYWPD
|| |  . |  |||. .||..| ..|||| .. .  ||| |||.|  .   . |||.||| . ...|||||.|. |..|| ..|      | || |||| 
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

RKGQSVEFGTIKVELMElePCTGGVARRMVMRK---GEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--YTHPLIIHCSAGVGRTGVVTSI
.  .  | . .||...|   .   | | . . .    .. |...||||  |||.|||...| |....| |.  . .    .....|||||||||||   .
kivikeerfkvkvdsve..eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

DSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTS
| ..   |. ..|||.||| ..||.|. .||   || ||| |.||. |. .. . .  |  .|..| . 
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk
subfamily_PTPRN_pd Subfamily PTPRN 583-823 9.4e-56 183.7 In-house 48-291 (297) alignment 
Range on Protein: 583-823
Range on HMM: 48-291/297.0
QTVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDD-KAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
..||... | ||||.|..|||| .||||.   .  .||| ||| |   |    ||||.|||  ... |||.|||.. |. | ..|.|.| .  .|..|||
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

DRkGQSVeFGTIKVELM-ELEPCTGGVARRMVMR--KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSID
|  |..| ..  .|.|. |   |   . | . ..  . .|.| ||||||  ||..|||  . |||.| . |   .   . |...|||.|.|||||   ||
de.Gsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

SVVAHA-KRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLED
 |...  |  . .|.   .  .|..|| .|.|..|. |...|| |.
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 584-824 3.4e-79 260.6 In-house 2-242 (250) alignment 
Range on Protein: 584-824
Range on HMM: 2-242/250.0
TVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIkCRQYWPDR
.||..  | .|||| .|...||.|| ||  .   .||| |||.. ..|. ||.||.||| .... ||||||..|...|| |.|.|.| .|  . ||||  
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

kgQSVEFGTIKVELMELEPCTGGVARRMVMRKGEESRR--VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-YTHPLIIHCSAGVGRTGVVTSIDSV
  .. ..| ..|.|.. |  .  . |.... | ... .  | |.||. |||||||... . |...|.|.| . |  . |.|..|||||||.|    ||.|
..kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

VAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDL
. ..|. ..||||...  .|..|| .|...||| |.| ..|. |
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPN13_pd Subfamily PTPN13 584-824 3.6e-69 228.1 In-house 30-269 (273) alignment 
Range on Protein: 584-824
Range on HMM: 30-269/273.0
TVAREQINFKKNRYKNILPYDSARVKLEVIDDiphsdYFNASYIP--SFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
.|.... | .||||.|.|||| .||||.         | |||.|     .|   |||.|||  ....|||.|||. ... |||||. .|..|.||..|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

DRKGQSVEFGT-IKVELMELEPCTGGVARRMVMRK--GEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqYTHPLIIHCSAGVGRTGVVTSID
..|....     ..|||....   | | |.. ...   .|||.|....|..||| |||... .||.|..||.  .   . |...|||||.||.|.. .||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

SVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDL
 |.   .| . .|| . | ..|..|  .|||..|| |.| |.|| |
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN3_pd Subfamily PTPN3 584-822 6.5e-68 223.7 In-house 34-273 (280) alignment 
Range on Protein: 584-822
Range on HMM: 34-273/280.0
TVAREQINFKKNRYKNILPYDSARVKLEVIDdipHsDYFNASY----IPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQY
..||   | .||||..|||||..||||.  .     || ||.|    ||| .  . |||.||| .... |||.|||......| |.| | |  ..|| ||
saarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPDrKGQSVEFGTIKVELMELEPCTGGVARRMVMRKGE--ESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSI
||. .....|.|...|.. . .  .  | | .|... |  |.|...|. ...|||.|||......|.|...|.. .   ..|...|||||.|||||.  .
WPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
.  .|   ... | . . | .||..|  .|||..|| |.  |.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
0037934 (Phosphotyrosine protein) phosphatases II 584-822 1.2e-66 220.1 In-house 3-240 (243) alignment 
Range on Protein: 584-822
Range on HMM: 3-240/243.0
TVAREQINFKKNRYKNILPYDSARVKLeviddiPHSDYFNASYIPSFDddKaYIASQGPNKTSMDD----FWRMVWQENVTTIAMVTKLQEGDKIKCRQY
..|. . | .||||..|||||  ||||      . |||.||..|. ..  . .||.||| . . .|    ||||.|....|.| |.|.|.| ...|| ||
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp..r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPdrkgQSVEFGTIKVELMELEPCTGGVARRMVMRK---GEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD----------HGQytHPLIIHCSA
||    ..|..|...|.|.. | . . . | ....    ....| |...|.. ||| ||| ....||.|..||..           ...  .|...||||
wp....gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpvlVHCsa

GVGRTGVVTSIDSVVAHAkrtRmVDVFNFVTNMRQKRPY-MVQTQEQYAFIYGAVLE
||||||..  .. .  .    . ||... |  .|..||. .|||..|| |.| |.||
GvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 584-825 7.3e-44 145.0 In-house 34-278 (307) alignment 
Range on Protein: 584-825
Range on HMM: 34-278/307.0
TVAREQINFKKNRYKNILPYDSARVKLEVidDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDR
||   . | .||||...   | .|. ...  |   |||  | |.    . | .|..||| .... .|| |. ||.| .. |. |. |  ||||.||||  
tveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

KGQSVEFG----TIKVELM---ELEPCTGGVA-RRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqyTHPLIIHCSAGVGRTGVVT
.||   ||    || |. .   .| |    .    . .  ...|| .... ...|||.|||.   . . ... |. |    | |...||||||||.| . 
egqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvGrsGtiv

SIDSVVAHA-KRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLL
.|  |     .     |. ..| ..|..|.| .||. || ...  .|| .|
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
0049772 (Phosphotyrosine protein) phosphatases II 584-826 1.1e-37 125.8 In-house 39-282 (314) alignment 
Range on Protein: 584-826
Range on HMM: 39-282/314.0
TVAREQINFKKNRYKNILPYDsARVKLEvIDDIPHSDYFNASYIPSFdddKAYIASQGPNKTSMDDF----------WRMV--WQENVTTIAM-------
.||.   | .||||..|||.|  ||.|    ..  |||.||||. .|   ...||.|||..  ..||          ||||  .. || .| |       
lvadlflnrdknryldilpad.nrvilp.glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VTKLQEGDKIKCRQYWPDRKgqsvefgtikvelmeleP-------CtggvarrmvmrkgeeSRRVTQFHFTEWPDKGVP--KHTSS
               ..| ..  . . ..... |                 .       .               .|.. ... . .|| ..|  ..  .
delsrLdaAlgKtpllildgngneptaadlellk.................eelydpelf...............erlgikylripvpDgsaplledfde

LLKFIKEVkadhgQYTHPLIIHCSAGVGRTG--VVTSIdsVVAHAkrtRMvDVFNFVTNMRQKRP-----YMVQTQEQYAFIYGAVLEDLLW
.|.||.|.     .  .|...||.||.||||  ||. .  .. .    .. ..   .  .|.|||      .....||| ||. |.|| | .
flefieea.....dkggpvlvHCkaGkgRtgtfvvaay..lmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_egg_pd Subfamily egg 584-821 2.9e-28 93.4 In-house 33-267 (307) alignment 
Range on Protein: 584-821
Range on HMM: 33-267/307.0
TVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDkiKCRQYWPDR
| | .. | .| | | .   ||.|||||.       |.  | ..        .| .| | | ..|||||||.||.|  | |.|  .| .  .|  |||  
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpka

KGQSVEF--GTIKVELMELEPCTGGVARRMVMRK-GEEsrrVTQFHFTEWpdKGVPKHTSSLLKFIkEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSV
. .|. .  |....| ....  .  . |   ..  | .     . .   |  .|  ...| .   . .|     . ..| ....  || ..... .|.  
esdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehw..qgdvnnssdvyspl.rvlrklrnlskpvvvqdilGvskaatlvaieia

VAHAKRTRM--VDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVL
. .  |  .    | . |  .|..|.. |..  .| |.|  ||
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 584-739 5.2e-06 19.4 In-house 19-157 (169) alignment 
Range on Protein: 584-739
Range on HMM: 19-157/169.0
TVAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNAsyipsfdddkayiasqgpnktsmddfwRMVWQENVTTIAMVtklqeGDKIKCRQYWPDR
 .|   .|  |||    |    .||||. . .   ||| ||                           ||.|. | . | ..     ||     ..||..
fmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfwpek

KGQSVEFGT---------IKVELMELEPCTGGVAR--RMVMRKGEESRRVTQ----FHFTEWPDKGVPKHT
.   .             . |    ..| | ||     . . ... .. ||.    .|.. ||..|||.  
edyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqsp
0042113 (Phosphotyrosine protein) phosphatases II 585-822 7.7e-72 236.9 In-house 3-241 (245) alignment 
Range on Protein: 585-822
Range on HMM: 3-241/245.0
VAREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDrk
||. . | .||||..|||||. |||| ...  ..||| ||||.. ..  . .||.||| . . .|||||.|....||| |.|.. | ...|| ||||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

GQSVEFGTIKVELMELEPCTGGVARRMVMR--KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG-QYTHPLIIHCSAGVGRTGVVTSIDSVV
|.|...|...|.|.. | . . . | . .   .  ||| |...|.. ||| ||| ....||.|...|.        .|...||||||||||..  .. ..
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

AHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
 ...... |.... |  .|..|| .|||..|| |.| |.||
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN23_pd Subfamily PTPN23 585-823 3.5e-64 211.4 In-house 37-279 (288) alignment 
Range on Protein: 585-823
Range on HMM: 37-279/288.0
VAREQINFKKNRYKNILPYDSARVKLEviddIPHSDYFNASYIPSFDDD-KAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDR
.|  ... .|||...|||||..||||.      . || |||.. .       .||.|.| .... |||.||... . .| |... .| .| |. .||| .
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPed

KGQSVEFGTIKVELMELEPCTGGVARRMVM--RKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKA----DHGQYTHPLIIHCSAGVGRTGVVTSI
||..|.|| ..| | . .     | | . .  .. .. . |.  ..|.||. |||.  ..||.|..||..     . .   ||..|||||||||||.. .
kgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

DSVVAHA-KRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLED
 ..|.   |.  ..|. . |  .|..| .|||..||. | | |||| 
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN14_pd Subfamily PTPN14 585-822 1.6e-56 186.5 In-house 43-294 (300) alignment 
Range on Protein: 585-822
Range on HMM: 43-294/300.0
VAREQINFKKNRYKNILPYDSARVKLEVIDDIpHSDYFNASYIPS--FDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPD
.|. . | .|||.|..|||. .||.|    .  ...| ||| |       .. ||..||| .. . |||.|||...|. |.|.|. .|. | |. .|.|.
taklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

R--KGQSVEFGTIKVE--LMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKA--DHGQY-------THPLIIHCSAGVG
   | ..||||  ||   . |  ...   . ..     .| | |  . .|.|||.|||.  .. |....||..   . .          |...|||||||
leskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
||||.   | ..|  .  . .|. . .. .|..| ..|||  || |.| ....
rtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 586-822 5.4e-70 230.2 In-house 2-238 (239) alignment 
Range on Protein: 586-822
Range on HMM: 2-238/239.0
AREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDD-DKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRK
|....|  |||| ||. || .|| || . . ||||| ||||.  .|   |||||.||  ..|  |||||.|||    | |.| | || | ||.|||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

GqsvEFGTIKVELMELEPCTGGVARRMVMRKG--EESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVA
    ..  ..| | . |  .  . | .|| .    | | | |.||| |||||||......| . ...  |    ..| .||||||||||| .  ||... 
s...kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
.||. . ||.||.|  .|. ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 586-822 6.7e-70 229.9 In-house 3-239 (239) alignment 
Range on Protein: 586-822
Range on HMM: 3-239/239.0
AREQINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDD-DKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRK
|....|  |||| ||. || .|| || . . ||||| ||||.  .|   |||||.||  ..|  |||||.|||    | |.| | || | ||.|||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

GqsvEFGTIKVELMELEPCTGGVARRMVMRKG--EESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVA
    ..  ..| | . |  .  . | .|| .    | | | |.||| |||||||......| . ...  |    ..| .||||||||||| .  ||... 
s...kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
.||. . ||.||.|  .|. ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 586-821 9.5e-53 173.8 In-house 33-274 (287) alignment 
Range on Protein: 586-821
Range on HMM: 33-274/287.0
AREQINFKKNRYKNILPYDSARVKLEVIDDiPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRkG
| |  . ||||| ..||.| .|| |    .   ||| || |..|. ||.|.||.|||  ... ||||.|...........|.  |  . || .|||.|  
aeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.e

QSVEFGTIKVELM---ELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEV-----KADHGQYTHPLIIHCSAGVGRTGVVTSI
. .  |   | |.    .||  |  | |..  ...|.| | |... .||||...  . .|..|. .|      |  .. . ||..|...|.||.|.. ..
vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

DSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVL
  .|   . .  ||| . |  .|..|  .||.  |. ..| |. 
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 586-747 5.1e-37 122.3 In-house 28-191 (297) alignment 
Range on Protein: 586-747
Range on HMM: 28-191/297.0
AREQINFKKNRYKNILPYDSARVKLEviDDIPHSDYFNASYI--PSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDR
|. .  ..||||..|| .|..||||     |. .|| || |.  |  . |  || .||| ....||||..|....| .|.||.||||. . ||  |||. 
akrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

KGQSVEFGTIKVELMELEP---CTGGVaRRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIK
...  . | . || .        .  .   . .   .||| |.   |  |||.|||     | .|  
vqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 588-821 2.5e-41 136.2 In-house 53-280 (290) alignment 
Range on Protein: 588-821
Range on HMM: 53-280/290.0
EQINFKKNRYKNILPYDSARVkleVIDDIPHSDYFNASYIPSFddDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQS
.. .|||||||..   | .||   ...|  . ||  | |.     .  .| .||. | .. |.|||| ||.|..| |. .| |  | || ||.|...|. 
kntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

VEFGTIKVELMELEPCTGGVARRMVMR---KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqythPLIIHCSAGVGRTGVVTSIDSVVAHA
. || | |   | .     . ....     .   . ..  ..   |||| |.. | .||. .. ..   |    |...|||||.||||  ..|.  .   
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqil

KRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVL
   . .|. . |  .|. |   || . ||  .  ..|
ldGkeldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 588-825 2.1e-37 123.4 In-house 52-290 (305) alignment 
Range on Protein: 588-825
Range on HMM: 52-290/305.0
EQINFKKNRYKNILPYDSARVKLeviDDIPHSDYFNASYIPS-FDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQ
 .|.  ||||...   | . |||   |. . |||  | |.   .  .| .|..|||   ..|.|| || |..|  | |. |  |  |.|| ||||  .|.
adiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

SVEF-GTIKVE-LMELEPCTGGV----ARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqytHPLIIHCSAGVGRTGVVTSIDSV
 .|. . | || .    |         .   .   |...  | ....|||||.|||    . |...  ..  .     |...|||||.|||| . .|. .
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyi

VAH-AKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLL
. . |.  .   . ..|  .|..| . .|.. || ||.  .|. .|
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 589-822 2.2e-68 225.2 In-house 18-262 (270) alignment 
Range on Protein: 589-822
Range on HMM: 18-262/270.0
QINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDD-DKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQ-
  . | |||..|||   .||.|| ... ... |.|| |.. ||. .|.|||..|| .|.. .||||.|.|.||.|.|.|.|.|  . || .||| .... 
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

-SVEFGTIKVELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTS------SLLKFIKEVKADHGQYT--HPLIIHCSAGVGRTGVVTSI
 ..|.|.|||  .. |  .| ...|. ...  |.||.. |....|||.|||...       .||| ...|.. . .    .||..||||||||||..  .
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
| .|   ..|. ||| . ....|..|. .||. |||.|.| ||.|
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 589-822 1.9e-37 123.6 In-house 46-285 (305) alignment 
Range on Protein: 589-822
Range on HMM: 46-285/305.0
QINFKKNRYKNILPYDSARVKLEviDDIPHsDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSV
  . .|||||..   |  |||||     || .|  | |. .  . | .| .| | . .  ||| | .|..| .| |. .|.|    || .|.. .... .
aqeagknrykdvgcldnnrvkle..gpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

EFG------TIKVEL---MELE-PCTGGVARRM--VMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqythPLIIHCSAGVGRTGVVTS
||       ..|.|    .... ..   | . .  .   ||..|.||..|. .|||.|||    ..|..... .. .|    |...|||||.|||| |  
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvm

IDSVVAHAKRTRMVDVF-NFVTNMRQKRPYMVQTQEQYAFIYGAVLE
.. ..      ....     .  .|..|   .||..|| |..  .|.
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_ptpA1_pd Subfamily ptpA1 589-776 4.3e-37 122.8 In-house 45-248 (418) alignment 
Range on Protein: 589-776
Range on HMM: 45-248/418.0
QINFKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFdDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQS-
. |  |||| |||| . .||.|. |.|   ||| || ||      | .|..|||   .. |||||||.. .  | |...  |  .||| .|||.. |   
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

--------VEFGTIKVELMEL--EPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQY------THPLIIHCSAGVGRT
          |||  |||.|.  .|    ..| . .    |.| .||...  |||. .| ||  . .... .   . |         |.|.|||||||||
fsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GVVTS
| . .
gtfct
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 589-824 5.7e-32 105.8 In-house 33-270 (285) alignment 
Range on Protein: 589-824
Range on HMM: 33-270/285.0
QINFKKNRYKNILPYDSARVKLEVIDdiphSDYFNASYIPSF-DDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQS
. |   ||| ..   . .|| |.  |     ||  ||..     |. .||..|||   .. |||.|..||... . |.  | ||   ||  |.|.. |. 
eanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

VEFGTIKVELMEL--EPCTGGVARRMVMRKGEESR----RVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQyTHPLIIHCSAGVGRTGVVTSIDSVV
|.||  .. | |   |  .| .   . . . |..      . . .   |||.  |. .  .... | ||    .  .|. .|||||||||  .  ||   
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidyat

AHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDL
 .      ..... | .||  |   ||.. |. |.|  ..| .
irimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 589-821 1.7e-23 77.5 In-house 49-282 (302) alignment 
Range on Protein: 589-821
Range on HMM: 49-282/302.0
QINFKKNRYKNILPYDSARVKLEVIDDiphsDYFNASY--IPSFDddKAYIASQGPNKTSM---DDFWRMVWQENVTTIAMVTKLQEGDKiKCRQYWPDR
. | |||. ...  .|| .||||   |    .| |||   .|..   .  | .| |...|    ..|||||.||..... .. . .| .|    ...| .
kknlkknqsedvpildsnlvkleaepd....syvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk

KGQSVEFGTIKVELMELEPCTGGVARRM--VMRKG-EESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSV
 |. .|.|.. |     |   . . | .  |. .|  .|  ..  ..| |..| ||.. ..| | ...| | . . .....|    |.|| |.. .   .
sgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

VAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVL
| . ..   . . . |...|..|| .|.. .||...| |.|
veklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 589-670 2.8e-07 24.4 In-house 35-121 (347) alignment 
Range on Protein: 589-670
Range on HMM: 35-121/347.0
QINFKKNRYKNILPYDSARVKLEV-----IDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQE
. . .||| |.    |..|| |           .   | |||.|   . .| || .| |   .. |||.||   .|| .  . . ..
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepik
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 590-825 4.3e-25 83.1 In-house 41-277 (312) alignment 
Range on Protein: 590-825
Range on HMM: 41-277/312.0
INFKK-NRYKNILPYDSARVKLEVIDDIphsdYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQsV
..||  ||| ||  .|  |  |   ...    |  | ..      . ....||| . .   ||...     |.| ... . |    || .|  |  |  |
lkfkdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf.v

EFGT----------IKVELMELEPCTGGVARRMVMRKGEESRrVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqytHPLIIHCSAGVGRTGVVTSID
..            |..     .  |  | . .|   |.||. . .. .. |||.|.|    . |...  || |.    .|.| |||||||||| .. |.
dledhrvyteycteieiggkskdkithrvlkvvvkatgqesk.lnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlalie

SVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLL
|..|  .  |  .| .    .|. |   |..  || .   .||| | 
smiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_eak_pd Subfamily eak 590-830 2.4e-20 67.2 In-house 51-311 (332) alignment 
Range on Protein: 590-830
Range on HMM: 51-311/332.0
INFKKNrYKNILPYDSARVKLEVIDdIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVE
 . ..|   .|.|||   |.|       .  | ||| .   .  . || .  .... .  ||.|| ...  .| .. .  | .  |  .|.||.  . ..
eavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

FGTIKVELMELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTS--SLLKFIKEVKAD-------------HGQYTH-----PLIIHCSAGVG
|| ..||  |         | ....||.|. ||  ...  | .  .||     .| | .||| .                .| |       || .. |  
fGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsa

RTGVVTSIDSVVA--HAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTL
|.||   || ..    .|.. .  | ...  ...|| . | .. |..||| .||. || ||  
raGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnr
Y_phosphatase Protein-tyrosine phosphatase 591-822 4.2e-81 267.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 591-822
Range on HMM: 1-235/235.0
NFKKNRYKNILPYDSARVKLevIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEF
|.||||||.|||||. ||||   ..  .||| ||.|. .....|..||.||| | ...|||||||||.|..|.|.|.|.| .. || ||||.....|...
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GTIKVELM-ELE-PCTGGVARRMVMRKGEES---RRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAK
|.|||||. . .  ... . | . ..| .|.   |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.. ..| .. ...
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

RTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
... |||...| ..|..|| |||. |||.|.| |.||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 591-822 4.2e-81 267.2 In-house 1-235 (235) alignment 
Range on Protein: 591-822
Range on HMM: 1-235/235.0
NFKKNRYKNILPYDSARVKLevIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEF
|.||||||.|||||. ||||   ..  .||| ||.|. .....|..||.||| | ...|||||||||.|..|.|.|.|.| .. || ||||.....|...
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GTIKVELM-ELE-PCTGGVARRMVMRKGEES---RRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAK
|.|||||. . .  ... . | . ..| .|.   |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.. ..| .. ...
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

RTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
... |||...| ..|..|| |||. |||.|.| |.||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 591-832 4.7e-46 152.0 In-house 1-179 (182) alignment 
Range on Protein: 591-832
Range on HMM: 1-179/182.0
NFKKNRYKNILPYDSARvkleviddipHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTklqegdkikCRQYWPdrkgqsvef
|..||||..|||||  |          ..|| ||... .   .. .|| ||| . .. ||.||......||| ..|         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gtikvelmelepctggvarrmvmrkGEESRRVTQFHFTEWPDKGVPKhTSSLLKFIKEVKAdhgqYTHPLIIHCSAGVGRTGVVTSIDSVVAHakrtRmV
                          .. | ..|.... ||| |||  ...||.||.||..      .| ..||||||||||..  .. .  .    . |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.v

DVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIP
.... |  .|..|| ||.| .|| |.. |.|| ||...| ..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 591-819 2.9e-36 119.8 In-house 33-254 (267) alignment 
Range on Protein: 591-819
Range on HMM: 33-254/267.0
NFKKNRYKNILPYDSARVKLEVIDdiphSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDkIkcRQYWPDRKGQSVEF
| ..||. . |||| .|| |   .     .| ||||. ..   .|.|. |.| | .. ||. .. ...|..| ..||  ... |  |..|| . ||. ..
nqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn.i..rlfwPPkmgqakky

GTIKVEL-MELEPCTGGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSS-LLKFIkeVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTR
  . ||  .| |     .    .  | | .. || ... .|  .   |     |.  .   | .  .  .||...||.||||.|    ||| .  ||.  
qdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgil..aknqlengnrPlvvacsdGvGrsGtflvidsqlerakteg

MVDVFNFVTNMRQKRPYMVQTQEQYAFIYGA
..|.|.|. ..|..|. .|.|.|.| .|.  
vsdifdflrkirsqriglvdtkeryiyihel
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 591-827 1.1e-35 118.0 In-house 43-274 (288) alignment 
Range on Protein: 591-827
Range on HMM: 43-274/288.0
NFKKNRYKNILPYDSARVKLEviDDiPHSdYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEF
|  ..||.|.   | .||||.  || |.  | .|  ..|   ..  | .| | .. .. .|.|. ...|  | |...| |  | |  .|.| ..|... .
nptrdryenlprcditrvkls..dd.pdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GTI----KVELMELEPCTgGVARRMVMRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVkadhGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKR
| .    |..  ...     |.   . ..|||.  | . |. ||.|.|||.   | |.... .     ....|...|.|||||||| .  |  ..  .. 
grlctvvkkkradidklv.kvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrl

TRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDLLWR
.  . . ......|..|   .||. || ...  |||.|| .
ddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 591-817 1.3e-32 107.6 In-house 52-283 (310) alignment 
Range on Protein: 591-817
Range on HMM: 52-283/310.0
NFKKNRYKNILPYDSARVKLEvIDDIPHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDrKGQSVEF
...|||| ...  |..||||. ||   . ||  | |. .    ...| |||| . .. |||||..||   .| .. |  |  . ||  |||   | .  .
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtety

GTIKVELM-----ELEPCTGGVARRM----VMR--KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqythPLIIHCSAGVGRTGVVTSIDS
| |.|  .     |.| |   |.       |       .  ||.  .. .|||.|||      .      .  ||    | ..|||||..|..||.... 
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg....pcvvhcsagkdrlyvvvalkl

VVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIY
 . ...|   ||. . .|.....|   .||. || .| 
kidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 591-683 3e-13 43.8 In-house 48-156 (349) alignment 
Range on Protein: 591-683
Range on HMM: 48-156/349.0
NFKKNRYKNILPYDSARVKLEVIDD--------------IPHSDYFNASYI--PSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKI
 | |||||.||||. .||||.                      || || |.  . .. .| ||| | |  ...|||....  ..|  .  ... .| .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCRQYWPDR
|| .|| . 
kcdiywqel
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 591-734 1.8e-08 28.3 In-house 96-234 (244) alignment 
Range on Protein: 591-734
Range on HMM: 96-234/244.0
NFKKNRYKNILPYDSARVKLEVidDIPHSDYFNASYIPSFDDDKAYIASQGPNK-TSMdDFWRMVWQENVTTIAMVTKLQEGDkikcrQYWPDRKGQSVE
|  |||    ||.|  || |          | |||..  .     || .| |   ||| |||.|. .  |  . ..  ..| |     .|||| .     
nswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsm.dfwkmmlerhvnvlvvlgsveeed.....eywpdseplewy

FGTIKVELMELEPCTGGVARRMVMRK--GEESRRVTQFHFTEWPDKG
   | | | . .      |  . .     |  . .| |  ..||  |
eeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdg
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 592-822 2.8e-66 218.1 In-house 4-237 (237) alignment 
Range on Protein: 592-822
Range on HMM: 4-237/237.0
FKKNRYKNILPYDSARVKLEVIDDIphSDYFNASYIPSFDD-DKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKgQSVEF
  |||| ||  || .|| |.       ||| ||.|. .||   | |||.||| ..| ||||.|||||. . | |.| | ||...|| .|||. . |   .
kiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaay

GTIKVELMELEPCTGGVARRMVMRKG---EESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEV--KADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAK
| . | |   |  .    | ... |    .| | . |..|| |||.|||..|..||.| |..  .. | . . | ||||||||||||..  ||... .||
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

RTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
  ..||..|.| .. . |||..||..|| ||. ..||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 592-695 3.2e-22 73.7 In-house 48-162 (350) alignment 
Range on Protein: 592-695
Range on HMM: 48-162/350.0
FKKNRYKNILPYDSARVKLE----VIDDIPH----SDYFNASYIP------SFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCR
| ||||||||||. .||||.      | . |    .|| ||.|.       . . |  ||| |.| .  .|||.... . .|. | ..|...| .  || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPDRkgqSVEFGTIKV
.||..    |..  |.|.
rYWqeg...sydditvkl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 593-819 1.9e-29 97.3 In-house 52-277 (301) alignment 
Range on Protein: 593-819
Range on HMM: 52-277/301.0
KKNRYKNIlPYDSaRVKLEVIDDIPHSDyFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGT
.|.||... | .     .|||.|        | .||.  . . .||.||| | ...||| |. | .| .|.|...  |  . ||..| | . ..... | 
dkhryptv.PckP.stavevivdGkrvP.ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

IKVELMELEPCTG-GVARRMVMR----KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqyTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRT
 |... . |      . .| .      .  ..| || . ..||.|.||||    | .... ||       .|...|||||.||.    . . .  . .  
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteylarevead

RMVDVFNFVTNMRQKRPYMVQTQEQYAFI-YGA
. ... . . ..|..|   |||..|  ..  |.
ptieltealkhlrehrwngvqtnsqlywmtlGt
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 594-840 1.3e-25 85.1 In-house 22-263 (290) alignment 
Range on Protein: 594-840
Range on HMM: 22-263/290.0
KNRYKNILpYDSARVKLEVIDDIPHSDYFNASYIpSFDDDKAYIASQGPNKTS-------MDDFWRMVWQENVTTIAMVTKLQEGDKI----KCRQYWPD
..|... |    .|| |..      .||. |... .. .. . |..| | .         . .|| |. ||.|. . |. . .| ..      | .| |.
dqRlevpL.veatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

RKGQSVEFGTIKVELMELEPCTGGVARRMVMR-KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKadhgQYTHPLIIHCSAGVGRTGVVTSIDSVV
. |... |. ..|.  . |   .   |..|..  .||   ||   . .| .  |...| .||. |. ||    ... | |.||  |. |  ....|.   
svgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgy

AH-AKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLedllwrntlipvIHFTDHL
   |. .  | . . . ..|..|  ........||.  ...            . ... |
Qkiaetsgsvkledvlkalrkqralaitsalelafvdagiv............llaievl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 601-732 7.8e-06 20.2 In-house 3-123 (130) alignment 
Range on Protein: 601-732
Range on HMM: 3-123/130.0
LPYDSARVKleviddipHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDkikcrQYWPDRKGQSVEFGTIKVELMEL
|... .|..          .| |||..   .  . |. .| |   .  |||.|. .  |  . ..  ..| |     .|||| .        | | | . 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdr

EPCTGGVARRMVMRKGEE--SRRVTQFHFTEWPD
.      |  . . .      . .| |. ..|| 
defknikasnleiesdlneshqaltmfqisnwps
0044763 (Phosphotyrosine protein) phosphatases II 602-819 7.5e-34 112.3 In-house 1-166 (178) alignment 
Range on Protein: 602-819
Range on HMM: 1-166/178.0
PYDSARVKLEVIDDIPHSDYFNASYIPSFdddkAYIASQGPnktsmDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGqsvefgtikvelmele
|.|  ||.|. . ... |||.|||.|  .     |..|..|      |..........|.| ..|. .|. ..|| .|||.. |                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

pctggvarrmvmrkgeesrrvTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHakrtRMvDVFNFVTNMRQ
                      |.... .|| |||  .. .|.|.. ... . .  .| ..||||||||.|..  .. .  .    .. .... .  .|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvre

KRPyMVQTQEQYAFIYGA
.|| .|....|. ..|  
rRp.ivpnpgqlrqLyef
0046846 (Phosphotyrosine protein) phosphatases II 613-820 1.7e-37 124.2 In-house 6-169 (176) alignment 
Range on Protein: 613-820
Range on HMM: 6-169/176.0
IDDIPHSDYFNASYIPSFdddkAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVefgtikvelmelepctggvarrmv
. . ...|| ||..| .     ..|| |||   .. ||..|......|.. ..|...| ...|| .|||. .. ..                        
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

mrkgeesrrvtQFHFTEWPDKGVPKHtSSLLKFIKEVKADHGQYtHPLIIHCSAGVGRTGVVTSIDsvvaHAKRTRMVDVFNFVTNMRQKRP-YMVQTQE
           |.... ||| ||| . . ||.......    .  .| ..|||||.||||..  ..      .. . ..|.. .  .|..|| ..|||.|
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYAFIYGAV
|| |.| ..
Qyrflyefe
0051429 (Phosphotyrosine protein) phosphatases II 616-823 5.7e-48 159.2 In-house 1-224 (272) alignment 
Range on Protein: 616-823
Range on HMM: 1-224/272.0
IPHSDYFNASYIPSFDD---DKAYIASQGPNKTSMDDFWRMvWQENVTTIAMVTKLQEGDKIKCRQYWP----------DRKGQSVEFGTIKVELMELEP
.| |.|.||.... .     ......|.|| . . .||||. ......|| ..... | .. || .|||          |.  .....| . | |.. | 
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

CTGGVARRMVMR---KGEESRRVTQFHFTEWPDKGVPKHTssLLKFIKEVKAdhgqyTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVD--------
..  . |.....   . .|.|.|...|.| ||| |||...  ||...... .      .|...|||||..|||.|  .. ...   .. .||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VFNFVTNMRQKRPYMVQTQEQYAFIYGAVLED
....|  .|..||..|||.|||.|.| |.|| 
leeaveelraqrpgavqteeqylflyeallel
0043147 (Phosphotyrosine protein) phosphatases II 617-817 4.4e-37 122.8 In-house 3-154 (172) alignment 
Range on Protein: 617-817
Range on HMM: 3-154/172.0
PHSDYFNASYIPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLqegdkikcrqywpdrkgqsvefgtikvelmelepctggvarrmVMRKG
..||| ||||..     . .|| |||    ..|||||......|.| ..|.|                                           .  . 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

EESRRVTQFHFTEWPDKGVPkHTSSLLKFIKEVKA-DHGQYTHPLIIHCSAGVGRTGVVTSIDSVVahakrtRMVDVFNFVTNMRQKRPYMVQTQEQYAF
 ..| . |.... ||| ||| ... ||.|.. ..   . .  .| ..||||||||||..  .. .       . ..... |  .|.|||..||...|| |
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IY
.|
ly
0051082 (Phosphotyrosine protein) phosphatases II 617-820 2.3e-34 113.5 In-house 1-149 (151) alignment 
Range on Protein: 617-820
Range on HMM: 1-149/151.0
PHSDYFNASYIPSFdddkaYIASQGPnktsMDDFWRMVWQENVTTIAMVTKLQEGDkiKCRQYWPDRKgqsvefgtikvelmelepctggvarrmvmrkg
|.|||.|.||. ..     ...|.||    ..||..........|| ......| .  .| .|.|.                                  
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

eesRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAdhgQYTHPLIIHCSAGVGRTGVVTSIDSVVAHakrtrmVDVFNFVTNMRQKRPYMVQTQEQYAFI
   ..|...... ||| |.| .. ..|.|.... .   .  .|...|||||.||||..  .. .  .      |...  .  .|.|||..||. .|. |.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YGAV
. |.
lfal
0036282 (Phosphotyrosine protein) phosphatases II 619-817 1.1e-43 144.2 In-house 2-163 (174) alignment 
Range on Protein: 619-817
Range on HMM: 2-163/174.0
SDYFNASYIPSFDDDKAYIASQGPNKtsmddFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDrkgqsvefgtikvelmelepctggvarrmvmRKGEE
|||.|||..  .   . .||.||| .     ||.|......||. |.....| .. || .|||.                               ..  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SRRVTQFHFTEWPDKGVPKHTSsLLKFIKEVKADHGQ-YTHPLIIHCSAGVGRTGVVTSIDSVVAHAKrTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIY
.| . |.... ||| |||  .  ||.|.|.|.  . .   .|...||||||||||..  .. .  . . ...||....|  .|..||.||||..|| |.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 626-823 4.6e-19 63.5 In-house 25-220 (255) alignment 
Range on Protein: 626-823
Range on HMM: 25-220/255.0
YIPSFDDDKAYIASQgpnktSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMElePCTGGVARRMVMR--KG--EESRR
. |. | ..  . |      ..| |.... | . ....|.. ..| .. || .|.|  | .   .  ..|   .  . .  | | ...    |   . . 
vkPekdkkrknlysl.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkktht

VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqytHPLIIHCSAGVGRTGVVTSIDSVVA------HAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAF
|. .... |..|  |. .  .|. .| |.       .....|||.|.||.     ...|        .   |  .|  ......|.||.  ..|  | ||
vkhysykGWieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf

IYGAVLED
    ||. 
silmvldl
0049260 (Phosphotyrosine protein) phosphatases II 627-817 1.2e-36 121.1 In-house 2-143 (152) alignment 
Range on Protein: 627-817
Range on HMM: 2-143/152.0
IPSFDDDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWpdrkgqsvefgtikvelmelepctggvarrmvmrkgeesrrvtQFH
|. .   ...|| |||   ...|||||... ..||| |.|.|.| .|.|| ||.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FTEWPDKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVahakrtRMVDVFNFVTNMRQKRPYMVQTQEQYAFIY
.. ||| |||...  || ... ..    .  .| ..||||||||||..  .. .       . |.....|  .|.|||..|....|. |.|
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 632-695 6.3e-08 26.4 In-house 234-293 (440) alignment 
Range on Protein: 632-695
Range on HMM: 234-293/440.0
DDKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQegDKiKCRQYWPDrKGQSVEFGTIKV
  .|.||.| |  ... ||||.| . ...|| |. .|.  ||  |  |||  . .|| || . |
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dk.tcsiywpv.ntrsvtfgpftv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 633-817 7.4e-23 75.7 In-house 4-197 (199) alignment 
Range on Protein: 633-817
Range on HMM: 4-197/199.0
DKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELEPCTGGVARRMVMR----KGEESRRVTQFHFT
.. |||.| | . .| |||.|||.     | ||   |   .     |||  .  . ..|.. |    .      .   ...         .| .... ||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWPDKGVPKHTsSLLKFI---KEVKADHGQY-THPLIIHCSAGVGRTGVVTSIDSVV-AHA-KRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIY
 | .|  |. .  .. |.   .||   . |    |.|.||| | | |||  ..|  | .|   .| .||.|.    .|| |  .. . ..| |||
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 633-817 1.2e-22 75.0 In-house 3-196 (198) alignment 
Range on Protein: 633-817
Range on HMM: 3-196/198.0
DKAYIASQGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELEPCTGGVARRMVMR----KGEESRRVTQFHFT
.. |||.| | . .. |||.|||.     | ||   |   .     |||  .  . ..|.. |    .      .   ...         .| .... ||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWPDKGVPKHTsSLLKFI---KEVKADHGQY-THPLIIHCSAGVGRTGVVTSIDSVV-AHA-KRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIY
 | .|  |. .  .. |.   .||   . |    |.|.||| | | |||  ..|  | .|   .| .||.|.    .|| |  .. . ..| |||
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 639-822 4.6e-07 22.8 In-house 120-307 (346) alignment 
Range on Protein: 639-822
Range on HMM: 120-307/346.0
S---QGPNKTSMDDFWRMVWQENVTTIAMvtkLQEGDKIK--CRQYWPDRKGQSVEFGTIKVELMELEPCTGGVA-RRMVMRKGEESRRVTQF-HFTEWP
.   |  |.. ..||| |..||..  . .   .   ||.|      . | .|     | . ..    .           |. .|.    . |  | . | 
aqlpqmenesfvedfwymiyqeqihlvyl...mvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwk

DKGVPKHTSSLLKFIKEVKADHGQYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
    | .|  ..|.|.. ....   .  . .    | ||.         .         .... . |..|.||  |..  ||| ||  |..
hlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 640-822 6.5e-21 69.1 In-house 97-286 (302) alignment 
Range on Protein: 640-822
Range on HMM: 97-286/302.0
QGPNKTSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELME----LEPCTGGVARRMV-------MRKGEESRRVTQFHFT
  | | ... .| .. | ||. .. .... |... || .|. |. |. ..||   |. ..    ||  |   . ..         .| .  . |  ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

EWPDKGVPKHTSSLLKFIKEVKAdhgqYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
 |||.| ||.. . |. .|  ..    | . ...|||||||||| . .|   .   .. .. |. . |. .|| |   ||...|  ..   |  
awpdhGapkeaytaldilkfces....ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtk
subfamily_hpo-7_pd Subfamily hpo-7 645-822 8.5e-16 52.6 In-house 45-225 (263) alignment 
Range on Protein: 645-822
Range on HMM: 45-225/263.0
TSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPDRKGQSVEFGTIKVELMELEPctGGVAR--RMVM--RKGEESRRVTQFHFTEWPDKGVPKHTS
  .| |.... | . ....|..  .| .. || .|.|  | .   .  ..|   .       . .   ..    .  . . |... .. |..|  |. . 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpelar

SLLKFIKEVKADhgqytHPLIIHCSAGVGRTGVVTSIDSVVA------HAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLE
. |. .| ..       ..|..|||.|.||.   . ...|        .   |  .|  ......|..|.  ..|  | ||    ||.
eilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
0048076 (Phosphotyrosine protein) phosphatases II 713-820 1.2e-21 72.4 In-house 38-139 (145) alignment 
Range on Protein: 713-820
Range on HMM: 38-139/145.0
MRKGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYtHPLIIHCSAGVGRTGVVTSIDSVVAhakrtRMVDVFNFVTNMRQKRPYMVQTQEQ
. .  ..| ..|.... ||| |||  .. ||.|.. ... . .  .| ..||||||||||..  .. .       . |.... .  .|..||..|....|
selellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgq

YAFIYGAV
. |.| ..
lrflyefe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 715-860 2.1e-35 116.9 In-house 84-230 (440) alignment 
Range on Protein: 715-860
Range on HMM: 84-230/440.0
KGEESRRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-YTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQY
.| ||| . |.|.  |||||||| .. .||.|..|.  . .    ||..|||||.|||||. ..||.. .|||.  .|.|.|. .||..|| |||| |||
ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

AFIYGAVLEDLLWRNTLIPVIHFTDHLQDLHTSGDGRGRSKMTKEFQ
||.. |||| ||  .|||     |.......       .| . .||.
afvheavlegllcgdtliledditerveqiqwpnphtdksplqqefe
0048179 (Phosphotyrosine protein) phosphatases II 720-817 1.7e-20 68.7 In-house 47-138 (144) alignment 
Range on Protein: 720-817
Range on HMM: 47-138/144.0
RRVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYtHPLIIHCSAGVGRTGVVTSIDSVVahakRTRmVDVFNFVTNMRQKRPYMVQTQEQYAFIY
| ..|.... ||| ||| ... ||.|.. ... . .  .| ..||||||||||..  .. ..    . . ..... .  .|..||..|....|. |..
regiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 721-822 1.8e-08 28.1 In-house 219-342 (349) alignment 
Range on Protein: 721-822
Range on HMM: 219-342/349.0
RVTQFHFTEWPDKGVPKHTSSLLKFIKeVKAD-----------HGQYTHPLIIHCSAGVGRTGVVTSIDSVVA----HAKR-------TRMVDVFNFVTN
 . |. . .|.| ..     |.|. .. || |           . . . .|..||||| |||||.  .|....      .        . . |.  .. |
ellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

-MRQKRPYMVQTQEQYAFIYGAVLE
 .|..|  |||   |. .|| |.|.
elrkqrismvqnlaqfiaiyealLk
PTPc_DSPc_SM00012 722-822 4.6e-33 108.9 In-house 2-105 (105) alignment 
Range on Protein: 722-822
Range on HMM: 2-105/105.0
VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQYT--HPLIIHCSAGVGRTGVVTSIDSVVAHAKRT-RMVDVFNFVTNMRQKRPYMVQTQEQYAFIYG
|...|.|.|||.|||....|.|.....||  . . .  .|...||||||||||... .| .. . ... . ||.|..|  .|..|| ||||.||| |.| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVLE
|.||
alle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 722-821 1.8e-13 45.0 In-house 217-341 (350) alignment 
Range on Protein: 722-821
Range on HMM: 217-341/350.0
VTQFHFTEWPDKGVPKHTSSLLKFIK-------EVKA-DH--GQYTHPLIIHCSAGVGRTGVVTSIDSVVA-------HAKRTRMV-------D-VFNFV
| |...  |.| ..  .  |.|. ..       .  |  |   . . |...||||||||||.. ..||..          |. | .       | ..  |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

TNMRQKRPYMVQTQEQYAFIYGAVL
 ..|..|  |||. .|. ||| |.|
nelrkqrismvqnldqfifiYeall
subfamily_PTPDC1_pd Subfamily PTPDC1 724-815 6.5e-08 27.2 In-house 84-167 (182) alignment 
Range on Protein: 724-815
Range on HMM: 84-167/182.0
QFHFTEWPDKGVPKHTsSLLKFIKEVKADHGQYthPLIIHCSAGVGRTGVVtsIDSVVAHAKRTrmvDVFNFVTNMRQKRPYMVQTQEQYAF
 ..   |.| ||.  . ..|  .| |.    .    . .|| || |||||.  | . . .|||    .  . .. .|.|||  .||.||  .
yvynfgwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvl..iacylvyakrl...taekaiklvrskrpksiqtreqvel
0038934 (Phosphotyrosine protein) phosphatases II 724-816 2.9e-07 25.8 In-house 81-169 (194) alignment 
Range on Protein: 724-816
Range on HMM: 81-169/194.0
QFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQY-THPLIIHCSAGVGRTGVVtsidsVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFI
...   .||.|..  .. ||.|.. |.  . .   .   .|| ||.||||..     |.|.   ..  ..   .  .|.||| ....|...  .
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtl.....vaaYLiyrlgmsaeeAialfrekRpgaipnqdyleal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 747-824 1e-17 58.9 In-house 219-295 (297) alignment 
Range on Protein: 747-824
Range on HMM: 219-295/297.0
KEVKADHGQyTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDL
. ..|.. .   .|..||||||||.|||   | ..|  .. |. ||  ... .|..|. .||| ||. ..| |||. |
eslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 755-819 1.6e-14 48.4 In-house 245-310 (319) alignment 
Range on Protein: 755-819
Range on HMM: 245-310/319.0
QYTHPLIIHCSAGVGRTGVVTSIDSVVAHAKRT-RMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGA
.   ||..||| ||||||.| . |  . . . . | ||. . |  .|. |   |.|.|||.|||  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 761-824 1.5e-15 51.3 In-house 2-65 (69) alignment 
Range on Protein: 761-824
Range on HMM: 2-65/69.0
IIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDL
..|||.| ||||   .|   .|  |  ..||.|| |  ||. || ||  . .| ||. |. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 761-824 4.7e-15 49.7 In-house 1-64 (69) alignment 
Range on Protein: 761-824
Range on HMM: 1-64/69.0
IIHCSAGVGRTGVVTSIDSVVAHAKRTRMVDVFNFVTNMRQKRPYMVQTQEQYAFIYGAVLEDL
..|||.| ||||   .|   .|  |  ..||.|| |  ||. || ||  ...| ||. |. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
0050432 (Phosphotyrosine protein) phosphatases II 820-1112 4.2e-77 254.8 In-house 8-301 (308) alignment 
Range on Protein: 820-1112
Range on HMM: 8-301/308.0
VLEDLLWRNTLIPVIHFTDHLQDLHT-SGDGRGRSKMTKEFQTLKSLCPdppASQTRSGRTPDNQPKNRYGNNLPLQRNRVILdSPDHDYINASQMKGV-
.|| ||.|.| |.|.... ...||.    .  ..... .||..| |..|     ...... |.|..|||| . ||. ..||.| ....|||||| ..|  
llelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgys

---HCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQND-KSCAQYWPNA---DSAQFGSYSVTTLSTSTDGDMTIRKLKITR-NSKTSHTVTQYQ
    ..|  || ||| || ||| || ... ..||||..  .|. . ||||||.    .| ..| ..||.||. ...|.|.|.|..|  ... |.|||...
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfh

FHGWPKHGSDQQsgARSLIKLIRAVKGSTnkmNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREY
...|| ||  ..  ...|......|. |    ..  |.|||  | ||||.....  .. |. .   ||.|..||.||  |.. |||.| | |.|.|. ||
ytnWpdhgvPps..peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley

LHT
|..
lkl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 826-1018 7.6e-15 49.2 In-house 41-235 (244) alignment 
Range on Protein: 826-1018
Range on HMM: 41-235/244.0
WRNTLIPVIHFTDHlQDLHTSGDGRGRSKMTKEF-QTLKS-LCPDPpaSQTRSGRTPDNQPKNRYGNNLPLQRNRVILD--SPDHDYINASQMK--GVHC
 .|  | .. | .  . . .|    |   .  .. |  .. . |||  |  .    |.|  ||| |  ||.. ||| |   |    ||||| .   |  .
tknryinilpfdet.rvilssskkegsdyinanyiqgsqniirpdp..svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrta

TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDkscaQYWPNADSAQFGSYSVTTLSTSTDGDMTIR--KLKITRNSKTSHT-VTQYQFHGWPKH
 .. || ||  |  ||| |.|. .   .|.|    ..|    .|||...  ..    .|   |  |    |.  .|.|  . . ||  .| .|   ||  
eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsd

GS
|.
gt
0051299 (Phosphotyrosine protein) phosphatases II 828-1110 3.8e-74 245.0 In-house 2-286 (288) alignment 
Range on Protein: 828-1110
Range on HMM: 2-286/288.0
NTLIPVIHFTDHLQDLHtsgdGRGRSKMTKEFQTLKSLCPDppaSQTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG--VHCTF
.| |.| ....... |.     .| ... .||..| ||.||    ...... | |..|||| . ||. ..||.| .    ...|||||| ..|    ..|
dteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkf

MTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQND-KSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITR-----NSKTSHTVTQYQFHGWPK
. || ||| ||.||| || ... ..||||..   .. . ||||||. .| ..| ..||.||. ...|.|.|.|..|.      ...|.|||......|| 
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpd

HGSDQqsGARSLIKLIRAVKGSTNkMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
||  .   ...|....|.|. . .  ..  ..|||  | ||||.....  .. |. ..  ||....||.||  |.. |||.| | |.|.|. |||
hgvpd..spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 828-1114 3.4e-63 208.6 In-house 2-287 (319) alignment 
Range on Protein: 828-1114
Range on HMM: 2-287/319.0
NTLIPVIHFTDHLQDLHTsgdgRGRSKMTKEFQTLKSLCPDppasQTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGVH--CTF
.| |.| .. ..|. |..     |  .. |||..||   .|    ...|  ...|..|||| | |. .| ||.|    .... |||||| . | .    |
dteievqeLkerlkalas....tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekf

MTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRNSKTS--HTVTQYQFHGWPKHGS
. || ||  |..||| || ... |..|||.. ... |  . .|||...  ..| . || ..     |. |||||. ..|      .|...|.  || |. 
iatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdv

DQQsgARSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
 ..  |.||..|.. .. |..| ..  | |||  |.||||  ..    . .. |   .|.|.||..||. |   ||..| | |||.|..|.... .
Pek..atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 830-1112 5.9e-59 194.3 In-house 1-285 (290) alignment 
Range on Protein: 830-1112
Range on HMM: 1-285/290.0
LIPVIHFTDHLQdlhtSGDGRGRSKMTKEFQTLKSlcpDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILD----SPD--HDYINASQMKG--VHCTF
|||| .|.....     |  .|.... ..|..|.|        ..  | |..|...||. | .. . ||..|      .|  ..||||. .||   .  .
lipvdkfgefva....nghakgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqy

MTTQMPLPATVSDFWSMVLNYKPSTIVMLND-KSQNDKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRNSK--TSHTVTQYQFHGWPKHGs
. || |.. |. |||... . | . |||| . .... . | ||||..|....| .|.. |. .|  ....|||... ...  ....|||||.  |...| 
iatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg.

dQQSGARSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHT
 .     . . .|. .     |  . ||.|||  . ||..|.|.|.  | .      .|.|| .|..|  ... |||...| .|.. . .||..
.kvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 831-1115 5.6e-67 221.0 In-house 2-285 (318) alignment 
Range on Protein: 831-1115
Range on HMM: 2-285/318.0
IPVIHFTDHLQDLHTsgdgRGRSKMTKEFQTLKSlCPDPpASQTRSgRTPDNQPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGVH--CTFMTT
|.| .. .|.. |..     |. ....|.. |.  ...  .....|  .| |. |||| | |. .. || |.    ... |||||. . | .   ... .
isvedleshvrrlre....sGelllseeyerlsr.seet.vtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaa

QMPLPATVSDFWSMVLNYKPSTIVMLNDKSQ-NDKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRN-SKTSHTVTQYQFHGWPKHGSDQQS
| ||| |..||| || . . ..|||| ....   . ...|||. .| ..|.  |.  .. . .|...|..|.||. .. | .| ||..  || .|. ...
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg

gaRSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTENY
   ||..|.| |.   .| ..  |.||| .| ||||| ..    . .|..   ||.|||||.||  |   ||||. | ||||.. |.|.. . 
..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
subfamily_PTPRB_pd Subfamily PTPRB 831-1114 2.2e-62 205.7 In-house 7-289 (293) alignment 
Range on Protein: 831-1114
Range on HMM: 7-289/293.0
IPVIHFTDHLQDLHTSGDgrgrSKMTKEFQTLKSLCPDPPasqTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGVHC--TFMTT
| . .|..|......  |     ....|...||..  |     . . ... |. |||| | || . .|| |    |... |||||. ..| ..   |..|
iklekfeehvkkmkadsd....lrfseeyeelkavgkdqa...vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCAQYWPNA-DSAQFGSYSVTTLSTSTDGDMTIRKLKITRnSKTSHTVTQYQFHGWPKHGSDQQs
| ||| || ||| ||.. | |.|||| .   . |  | .|||.  .. ..|. .|| .....  | .||.|||.. .|....|.||.|  || ||  .. 
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPek.

gARSLIKLIRAVKGST-NKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
 ...|....|.|. .. .....  |.||| .| ||||.. .  . . .| |.| |||| .|  || .|...||||..| ||.... ..|....
.tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_PTPRG_pd Subfamily PTPRG 831-1116 3.8e-58 192.1 In-house 1-293 (563) alignment 
Range on Protein: 831-1116
Range on HMM: 1-293/563.0
IPVIHFTDHLQDLHTSGDGRgrskMTKEFQTLKSLCPDPpASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDS-PD----HDYINASQMKGVH--CTFMT
.|| .|. |. .||..|| .    ...||. |.| . .    .. . . |.|. |||| | .. .| || | . |.    .|||||. ..| .    |..
vpvkefakhvaslhadgdig....fseefealqsetisk.dldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafia

TQMPLPATVSDFWSMVLNYKPSTIVMLND-KSQNDKSCAQYWPNADSAQFGSYSVTT-----LSTSTDGDMTIRKLKITRNSK--TSHTVTQYQFHGWPK
|| ||. |. ||| |. . . ..|||. . . .. . | .|||. .| ..|. .||      |...|   ..|..||. ....  | ..|.||..  || 
tqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

HGSDQQsgarSLIKLIRAVKGSTNKMNE-FSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
||. ..    || .|| ..| |. ...|   |.||| .|.||||...     . || ....|..|...|..|| |   |||||.| |..||. | . ...
hgvPeh....slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

YE
 |
te
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 833-1114 1.1e-70 233.3 In-house 7-294 (298) alignment 
Range on Protein: 833-1114
Range on HMM: 7-294/298.0
VIHFTDHLQDLHTSGDGRGRSKMTKEFQTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGVHC--TFMTTQM
. ... .|| | .     . .....|||.|.|   . .. ... .|.|.|. |||| . ..|.  ||.| .     . |||||| ... .   .|..|| 
aedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqa

PLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRNS-KTSHTVTQYQFHGWPKHGSDQQsgA
||..||.||| || ... .|||||..  . ||  . .|||.  ....|. .|. ||. . .|...||||..... .....| | .|  || .|  ..  |
PltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpen..a

RSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
.|...|.| |. |...  . ...|.| .| ||.|  .     . .. .  .||.||.||.||..|.. |||||.|.|||.|. |.|.. |
tsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0043336 (Phosphotyrosine protein) phosphatases II 834-1110 7.9e-65 214.4 In-house 5-277 (278) alignment 
Range on Protein: 834-1110
Range on HMM: 5-277/278.0
IHFTDHLQDLHTSGDGRgrskMTKEFQTLKSLCPdppaSQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGV--HCTFMTTQMP
 .. ..|..|. ..  .    . .||..| |  .      .. .. |.|..|||| . ||. ..||.|.. .    .|||||| ..|     .|  || |
kdllkallelllnlktl....lllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgP

LPATVSDFWSMVLNYKPSTIVMLNDKSQND-KSCAQYWPnADSAQFGSYSVTTLSTSTDGDMTIRKLKITR-NSKTSHTVTQYQFHGWPKHGSDQqsGAR
|| || ||| || ... .|||||..   .. . ||||||  .| ..| ..||.|.. ...|.|.|.|..|.  .. |.|||.|...||| ||        
lpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..sls

SLIKLIRAVKGSTNkMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
.|.....||.   .  ..  .||||  | ||||.....  .. |.  .  ||....||.||  |.. |||.. | |.|.|..|||
llldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 837-1114 2.8e-57 189.0 In-house 10-301 (306) alignment 
Range on Protein: 837-1114
Range on HMM: 10-301/306.0
TDHLQDLHTSGDGRGRSKMTKEFQTLKSLCPDPPAsQTRSGRTPDNQPKNRYGNNLPLQRNRVIL---DSPDHDYINASQMK----GVHCTFMTTQMPLP
 .. ..|. ...  ... ...||..|.         . . |. |.|. |||| | ||   .||||   . |..|||||...|    | ......||  |.
eqrvselekeeeslekagfeeefeelqqeeakkll.srkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle

ATVSDFWSMVLNYKPSTIVMLNDKSQN-DKSCAQYWPNAD-SAQFGSYSVTTLSTSTDGDMTIRKLKIT--RNSKTSHTVTQYQFHGWPKHGSDQQSGAR
.||||||.||.. .   |||.  .     . ||.|||..  . ..|..|||..| ..  | ..|.|...  ...|....| ||.|. || ||  .. || 
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgav

-SLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCT---AMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
 .... ... . ....... .|.||| .| |||| .      .. | .      .|| ..||..|. | ..||||. | |.| ||..|..|..
LdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
0040438 (Phosphotyrosine protein) phosphatases II 838-1111 6.4e-68 224.7 In-house 7-277 (317) alignment 
Range on Protein: 838-1111
Range on HMM: 7-277/317.0
DHLQDLHTSGDgrgrSKMTKEFQTLKSLCPDppasQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSP----DHDYINASQMKGV--HCTFMTTQMPLPAT
..|.||. |.      .. .||..| || .|     .. .. |.|..|||| . ||. ..||.| ..    |.|||||| ..|     .|  || ||| |
lalldllksdf....talleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpnt

VSDFWSMVLNYKPSTIVMLNDKSQN-DKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITR-NSKTSHTVTQYQFHGWPKHGSDQqsGARSLIK
| ||| || ... ..||||..  .. .. ||||||. .. ..| ..||.||. .....|.|.|...  ....|.|||.....||| ||  .    ..|..
vedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spdllld

LIRAVKGSTNkMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLH
...||. . .  ..  .||||  | ||||....|  .. |. ..  ||....||.||. |.. |||.| | |.|||..||| 
fleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 839-1114 1e-55 183.8 In-house 6-282 (287) alignment 
Range on Protein: 839-1114
Range on HMM: 6-282/287.0
HLQDLHTSGDGRGRSKMTKEFQTLKSLCPDPpASQTrSGRTPDNQPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGVH--CTFMTTQMPLPATVSDFW
.. ..  .|  .|.   .. |..|...  ..  . |  . ...|..|||. . |. . .||.|   ..|||||. ..| .    |. .. |.  |. .||
kfgefvakghakgnegfknqftvleqvtqre.devt.hniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfW

SMVLNYKPSTIVMLNDKSQN-DKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRNSKT--SHTVTQYQFHGWPKHGSDQQSgARSLIKLIRA
 .. . ....|||| .. .| .. | ||||. .|  .| |... |.  .  ....|||......|.   ..|.|||.  |...|  ..  . .|. . . 
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep.qtillvieem

VKGStNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
.|    |  . ||.|||  . ||....| |   | .  .   .|.|| .|  |  ... ||| |.| ||.|.. |||.. .
yktq.rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_PTPN9_pd Subfamily PTPN9 841-1111 3.5e-50 165.7 In-house 4-291 (297) alignment 
Range on Protein: 841-1111
Range on HMM: 4-291/297.0
QDLHTSGDGRGRSKMTKEFQTLKSlcpDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSP----DHDYINASQMKGV--HCTFMTTQMPLPATVSD
..| .    .|.. ..||.. ...    |.. .    ... |  |||| . | ... || | .       |||||. . |   . .|..|| ||. ||||
eelvayvkekgkrGlskeyaeirn...epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWSMVLNYKPSTIVMLNDKSQNDK-SCAQYWP--NADSAQFGSYSVTTLSTSTDGDMTIRKLKIT-RNSKTSHTVTQYQFHGWPKHGSDQQsgARSLIKL
|| || . .  .|||     .. .  |.||||  . .||.||..||..... .  | ..|.|.|.  . . | .|| .|| .|| .|  ..  | ||...
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPss..aaslldv

IRAVKG---S---------TNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLH
...|.    .         . ....  |.||| .| |||| ..|   |.... | . ||...|||.||. |   .||.| |.| | |. ||  
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 846-1108 1.5e-65 216.1 In-house 14-277 (288) alignment 
Range on Protein: 846-1108
Range on HMM: 14-277/288.0
SGDGRGRSKMTKEFQTLKSLCpdpPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGVHC--TFMTTQMPLPATVSDFWSMV
  . |.|. ...|...| .|      ...  || . |..|||| | ||.  .|| |.     .. |||||| ..| .   ....|| ||..|| ||| .|
kksarnrtgfseeynsLaale...ktksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

LNYKPSTIVMLNDK-SQNDKSCAQYWPNADS-AQFGSYSVTTLSTSTDGDMTIRKLKITrNSKTSHTVTQYQFHGWPKHGsdQQSGARSLIKLIRAVKgS
 ..| ||||||..   .... | .|||.||   ..||  || ... . .|.. ||| .   .||  ..||||. .|| ||      .. |..|.| ||  
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhg..vPeskapllellrqvk.v

TNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIRE
.|. .   |.|||  | ||||.  ..   | .. | | .|.. ||. ||  |...|||.. | |||... .
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0047943 (Phosphotyrosine protein) phosphatases II 850-1110 7e-71 234.2 In-house 9-272 (273) alignment 
Range on Protein: 850-1110
Range on HMM: 9-272/273.0
RGRSKMTKEFQTLKSLCPdppASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDHDYINASQMKG--VHCTFMTTQMPLPATVSDFWSMVLNYKPSTI
 |.... .||..|.||.|      .. .. |.|. |||| . ||. ..||.|.....|||||| ..|  .  .|. ||.||| || ||| || ... ..|
lgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMLNDKSQNDK-SCAQYWPNAD---SAQFGSYSVTTLSTSTDGDMTIRKLKITR-NSKTSHTVTQYQFHGWPKHGSD-QQSGARSLIKLIRAVKGSTnkM
|||..  ....  ||||||.     | ..| ..||.||. |..|.|.|.|..|. ... |.|||.....||| ||   . .   ..|.|.| .  ..  .
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal..p

NEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
..  ..|||  | ||||.....  .. |. ..  ||....|| ||  |.  |||.| | |.|.|. |||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 850-1110 7.3e-70 231.1 In-house 29-289 (297) alignment 
Range on Protein: 850-1110
Range on HMM: 29-289/297.0
RGRSKMTKEFQTLKSLCPDppasqTRSGRTPDNQPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKGVHC---TFMTTQMPLPATVSDFWSMVLN
 ..... .||..|.|| ||     .. .. | |..|||| . ||. ..||.| .     .|.|||||| ..| ..   .|  || ||| || ||| || .
nsktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

YKPSTIVMLNDKSQNDKSCAQYWPNADSaQFGSYSVTTLSTSTDGDMTIRKLKITRnSKTSHTVTQYQFHGWPKHGSdqQSGARSLIKLIRAVKGSTNKM
.. ..||||..   ... ||||||.  . ..| ..||.|.. .....|.|.|..|. .. |.|||..|..||| ||    . ...|......|.   .. 
qgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgv..ppslellleflelvrealael

-NEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
 ..  .||||  | ||||....|  .. |. ..  ||....||.||  |.. |||.. | |.|||..|.|
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_PTPN23_pd Subfamily PTPN23 850-1112 1.9e-51 169.6 In-house 12-282 (288) alignment 
Range on Protein: 850-1112
Range on HMM: 12-282/288.0
RGRSKMTKEFQTLKSLCPDPpASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGVHC---TFMTTQMPLPATVSDFWSMVLNYKPST
 |.... |.|. |..      | ..       .  |||. . ||  .||| |..   |||||| .|..     .|..|| ||. |..|||.|| . | |.
dgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLNDKSQNDK-SCAQYWPNAD--SAQFGSYSVTTLSTSTDGDMTIRKLKITRN-SKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKG---STN
|||| .|.. .| ....|||..   . .|| .|||  |. . . .  |.||.. . ... ..|.  |.. ||..|  .     .|.... .|.    ...
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPas..Petllqfldevesayeavq

KMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDS-VDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHT
.  .  ..|||..| |||||..  .  .... ...  .|| | |..||..|   ||..|.. | |.|. |. . 
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 850-1118 3.2e-28 93.6 In-house 13-288 (307) alignment 
Range on Protein: 850-1118
Range on HMM: 13-288/307.0
RGRSKMTKEFQTLKSLCPDPPASQTRSGrtpdNQPKNRYGNNLPLQRNRVILDSP--DHDYINASQMKG--VHCTFMTTQMPLPATVSDFWSMVLNYKPS
.| .... ||. |    |.  . .. |     |. |||| .    ...|...  .    ||| |  .        |. .| || .|. .||.|... |  
kgvqalvdefrvlakktpegvtveafsa....ntdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekve

TIVMLNDKSQNDK-SCAQYWPNADS--AQFGSY----SVTTLST---STDGD-MTIRKLKITRNsKTSHTVTQYQFHGWPKHGSDQQSgaRSLIKLIRAV
...|| .  .  |  | ||||  .     ||.     ||. | .   . | | . . .||.    . | |....|.. || .|  |     . | |. ||
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqin..ltainlleav

KGSTNkmnefSILVHCLSGAGRTGVLCTAMECI-AQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREY---LHTENYEQL
.. ||      ..||| .| ||.| . .        ||  .  |. . |. ||..|   .||| .| ...  . ||   |. | ||.|
rydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel
0036941 (Phosphotyrosine protein) phosphatases II 851-1116 3.8e-71 235.1 In-house 11-283 (297) alignment 
Range on Protein: 851-1116
Range on HMM: 11-283/297.0
GRSKMTKEFQTLkslCPDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGVH--CTFMTTQMPLPATVSDFWSMVLNYKPSTIV
..... |||..|   .|  .   .. .. |.|..|||| . ||. ..||.||....|||||| ..| .   .|. || ||| || ||| ||.... ..||
flalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLNDKSQNDK-SCAQYWPNA--DSAQFGSYSVTTLSTST--DGDMTIRKLKITR-NSKTSHTVTQYQFHGWPKHGSDQqsGARSLIKLIRAVKGSTNKM-
||..  ....  ||||||.   .| ..| ..||.||...  ..|.|.|.|..|  ... |.|||.....||| ||  .   ..||...|..|.   ... 
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldfielvrkvlkllp

NEFSILVHCLSGAGRTGVLCTAMECIAQIA---ERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTENYE
..  .||||  | ||.|....|  .. |.    ..  |||...||.||  |.. |||.| | |.|.|. |.| . .. 
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0045450 (Phosphotyrosine protein) phosphatases II 851-1110 5.9e-65 215.3 In-house 25-304 (307) alignment 
Range on Protein: 851-1110
Range on HMM: 25-304/307.0
GRSKMTKEFQTLKSLCPDPpASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKG----------VHCTFMTTQMPLPATVSDF
..... |||..|.|.....    ..... | |..|||| . ||. ..||.| |     .|.|||||| ..           .  .|. || ||| || ||
fltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WSMVLNYKPSTIVMLNDKSQNDKS-CAQYWPNADSA-QFGSYSVTTLSTSTDGDMTIRKLKITR--NSKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLI
| |. ... ..||||..   ...  ||||||. ..  ..| . ||.||.......|.|.|..|.   .. |.|||.....||| ||  .     .|...|
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps..feelldfi

RAVKGSTNKM-NEFSILVHCLSGAGRTGVLCTAMECIAQIAERDS---VDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
..|.   ..  ..  .||||  | ||||....|  .. |. ..     ||....||.||. |.. ||..| | |.|.|..|.|
eevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 851-1112 4.7e-57 188.1 In-house 6-279 (290) alignment 
Range on Protein: 851-1112
Range on HMM: 6-279/290.0
GRSKMTKEFQTLKSLCPDPPASQ---TRSGRTPDNQPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGV--HCTFMTTQMPLPATVSDFWSMVLN
|. ...||||.||.|     |..   | .|... |. |||| . || . .|| |     ... |||||. .|||  ..... .| |||.|..||| |. .
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwe

YKPSTIVMLNDKSQNDK-SCAQYWPNA--DSAQFGSYSVTTLSTS-TDGDMTIRKLKITRNsKTSHTVTQYQFHGWPKHGSDqqSGARSLIKLIRAVKGS
.. . .||.  .  ..|  |..|||.   .. .||...||. .   .| |..|| ||.... |.|..|.|.... || ||    |.| ||..||..|.  
knveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvP..ssaksllelielvrel

TNkMNEFSILVHCLSGAGRTGVLCTA---MECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHT
 .  ..  ..||| .| ||||....     | . .    ...|.|. | .|| .|   |||.| | ..| |. |....
qe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_PTPRN_pd Subfamily PTPRN 851-1109 1.3e-38 127.4 In-house 27-291 (297) alignment 
Range on Protein: 851-1109
Range on HMM: 27-291/297.0
GRSKMTKEFQTLKSLCPDPPASQtrSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKG---VHCTFMTTQMPLPATVSDFWSMVLNYK
 .... ||...|..   .| ...   .....|  |||. . || . .|| |..     ..||||||..      . ....|| ||..||.||| || .  
nkdrlekewealcayeaepstke..vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

PSTIVMLNDKSQN-DKSCAQYWPNADSAQFGSYSVTTLSTSTD-GDMTIRK--LKITRNSKTsHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTN
   ||.|   ...  | |..|||.  |. .. | |  .|      |  .|   ||  ..|.|  ||||. |  ||..|   .  |.||... | |  |  
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPas..aksllefrrkvnksyr

KmNEFSILVHCLSGAGRTGVLCTAMECIAQIAE-RDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREY
     .|.||| .||||||| .     .....     .||  |.. || .| ..|.|.... |.. |. | 
G.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 851-1115 1.8e-26 87.5 In-house 22-293 (305) alignment 
Range on Protein: 851-1115
Range on HMM: 22-293/305.0
GRSKMTKEFQTL-KSLCPDPPASQTRSGRTPD-NQPKNRYGNNLPLQRNRVILDSPD-HDYINASQMKGV---HCTFMTTQMPLPATVSDFWSMVLNYKP
|  |. .||. | |   ||       . ...| .. |||| .    ... | || |   ||| |  .      .  |. .| ||  |. .|| ||.. | 
gvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkv

STIVMLNDKSQNDK-SCAQYWPNADSAQF---GSYSVTTLSTS----TDGDMTIRKLKITRNSKTSHTVTQYQFHGWPKHGSDQQSgaRSLIKLIRAVKG
  ||||    .  |  |||||| |   .    .   |  .| |     | .. |  |..| . . . .| . |.  ||  |        . ..|. |..|
eqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppck..ltslellsairg

StnkmnEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSV-DIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHtENY
|     .  |.||| .| |||| . .    . .|||  ..  . . ||.|| .|   .|.. .| ||.  . .|.  |.|
s.....kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl.eky
subfamily_CG7180_pd Subfamily CG7180 852-1111 1.6e-47 156.6 In-house 12-291 (296) alignment 
Range on Protein: 852-1111
Range on HMM: 12-291/296.0
RSKMTKEFQTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGV--HCTFMTTQMPLPATVSDFWSMVLNYKPS
| |.  |.. .  | |     . . |   .|. |||. . .|   |||.|..     . |||||. . .   .  .. |..|   || .||..| . . |
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIVMLNDKSQNDKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRN-----------SKTSHTVTQYQFHGWPKHGSDqQSGARSLIKLIRAV
..|.| .. .  | . .||||   .|.|   | .... .  ...||..|.|..           .    .|...|.  |. . .   . . .||.|.| |
avvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkv.Plstnalielrrrv

KGSTNKM----NEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLH
.   .|.    .|  ..|..  ||.|.|| ...  .. .. . . ||.|. ||||| .| | |.. ||| .||| . |.. 
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 853-1110 7.3e-35 115.3 In-house 20-279 (439) alignment 
Range on Protein: 853-1110
Range on HMM: 20-279/439.0
SKMTKEFQTLKSLCPDPPASQTRSGRTPdNQPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGVHC--TFMTTQMPLPATVSDFWSMVLNYKPST
  ....|....|  ||  .  .   .   .|.|||| .  ...  ||.|      |   ||||  .|| .    ...||.|   |. ||| .|.. | .|
eifkeifekinstspdyaciaslaaqey.dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvt

IVMLNDKSQNDKscaqYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRN---SKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTNKMNE
|||| .  .  |    |||  . . .|  .| .       . .|| .|.  .   ..  .|| |...  ||..    |  |  .....||.. . .| . 
ivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeey

FSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
  ..||| .| |||| . .   .. |.   . |||   || || .| |.||.  .| |||.|. | .
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 853-1110 4e-34 112.8 In-house 6-259 (267) alignment 
Range on Protein: 853-1110
Range on HMM: 6-259/267.0
SKMTKEFQTLKSLCPDppASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGVH--CTFMTTQMPLPATVSDFWSMVLNYKPSTIVML
 .. |||. .| . ..   |.     . .|| .||. .||| . .||||   ...||||| ..| .   .|. || ||  |..||. .. ..| ..||.|
ceiekefelikkisdt..sstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NDkSQNDKsCAQYWPNA--DSAQFGSYSVTTLSTSTDGDMTIRKLKITRNSKTSHTVTQYQFHGWPKHGSdQQSGARSLIKLIrAvKGSTNKmNEFSILV
   .  |.   ..||    .. ..   .|       . |  |  |..  . ...| || | .. |      ..   . |. .. | |   ..  .  ..|
tk.vftdn.irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintn.nkpylkplfgil.a.knqlen.gnrPlvv

HCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
.|  | ||.| . ..   . .. . . .|||. .. .|  |. .|.| |.| .|.. . || 
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 854-1111 2.3e-51 170.0 In-house 35-293 (319) alignment 
Range on Protein: 854-1111
Range on HMM: 35-293/319.0
KMTKEFQTLKSLCPdPPASQTRSgRTPDNQPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGVHC--TFMTTQMPLPATVSDFWSMVLNYKPSTI
|.  ||. .  | . . | || .   ..|. |||..| |.  .|.| |.  .     |||||| ..|      ....| ||. |. ||| |. .|. |||
klevefrracklgv.nladqtfa.nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLNdksqnDKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRN--SKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTNKMNE-F
|.|       . |.||||.    . . . |   |     . ..|.......   |    .||. | |||..|  ..  .  |..|.. |.  |.|.|.  
vllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy..psdlmrlvkkvrhltskenhra

SILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIRE-YLH
.|.||| .|.|||||  .    . .. | . ||....|. || .| ..||   .| ||| |. | .| 
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 854-1112 1.3e-49 163.8 In-house 16-278 (281) alignment 
Range on Protein: 854-1112
Range on HMM: 16-278/281.0
KMTKEFQTLKSLCPDPPASQTrsgRTPDNQPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGVH--CTFMTTQMPLPATVSDFWSMVLNYKPSTI
 ...|...|...  | .|. .   ....|. |||| |       || .    .. . |||||. ..|..    ...|| |.||.. .|| ||...| |.|
Gfieeyeklaaigvdntatas...kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMLNDKSQNDK-SCAQYWPNAD-SAQFGSYSVTTLSTSTDGDMTIRKLKITRNSKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTNKMNEFS
||.  . ...|  | .|||. . . ..| . |.......   .  ||.|..|.|  . .|.| ..  || ||  ..  .. |..  ..|.  |.| .. .
vmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPat..tkellefrkevlkltekktkap

ILVHCLSGAGRTGVLCTAMECIAQI-AERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHT
...|| .| ||||.  .    . .. ||. ..|. ..|. || .|. .|||   |.|.| |. ..|. 
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 854-1113 1.1e-38 127.7 In-house 11-280 (287) alignment 
Range on Protein: 854-1113
Range on HMM: 11-280/287.0
KMTKEFQTLKSLCpDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILD-SPDH--DYINASQMKGVH--CTFMTTQMPLPATVSDFWSMVLNYKPSTIV
.. ||...||    .  .   ..     .  ||||.. ||.  .||.|   ...  |||||  . . .   .|...| |..||| ||| .||. . ....
dvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

ML-NDKSQNDKSCAQYWPNADS-AQFGSYSVTTLST-STDGDMTIRKLKITRN-SKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVK----GSTNK
..  .  .  . | .|||. .   . | |||. |.    . . ..| |..    .. .. | |...  ||...      | .||...  ||     . . 
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPt..avglirfvldvkqhielarda

MNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTE
 .   ..||.  |.||.|.| . . .. .  .   ||. ..|  ||  |  .||.   . ..|.|.  | .|.
sevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 854-1115 4.9e-34 112.3 In-house 28-288 (290) alignment 
Range on Protein: 854-1115
Range on HMM: 28-288/290.0
KMTKEFqtLKSLCPDPPASQTRSGrTPDNQ---PKNRYGNNLPLQRNRVIL-DSPDHDYINASQMKGVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVM
...||.  |. | |  |. .       |..    |||| .    .. |||| |  | ||. |  .||.. .|. || .| .|| |.| |||. | ..|||
elakey..leklkpylpvqylerk.ifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivm

LNDKSQNDKS-CAQYWPNAD--SAQFGSYSVT-TLSTSTDGDMTIRKLKIT-RNSKTSHTVTQYQFHGWPkhgsdQQSGARSLIKLIRAVKgSTNKMNEf
| .  .. |. |.||.|. .     ||...|. ..... | ..  . | .  ..|  .| .  ..   ||     ..| | | . |.| .. .  |..  
lceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswp.....dksvalstlallrtlr.ilrkasG.

SILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTENY
 . ||| .| |||| . .   ..  . .  ..|. ..|..||  |.. || . .|  . ... ..    .|
pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky
subfamily_ptpA1_pd Subfamily ptpA1 854-1066 4.2e-30 99.8 In-house 22-252 (418) alignment 
Range on Protein: 854-1066
Range on HMM: 22-252/418.0
KMTKEFQTLKSLC-PdppaSQTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGVHC-TFMTTQMPLPATVSDFWSMVLNYKPSTI
|. .||. |.    |    |.|  |    |  |||| | ||... || |    |    |||||  . | .   |. || ||| |..||| || . .   |
kikeefrlleesvgp....setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcrii

VMLNDKSQNDK-SCAQYWPNAD-----------SAQFGSYSVTTLSTSTDGD--MTIRKLKITRNSKTsHTVTQYQFHGWPKHG-SDQQSGARSLIKLIR
|||. .|.| .  | .|||.                ||.|||  .    | .  .  |....| . .| . .||||. ||| |   |.    | |.. | 
vmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeget.rditqyqyegwpdhnipdhtqpfrqllhsit

AVKGS--TNKMNEFSILVHCLSGAGRTGVLCTAMEC
  .     .   .  |.||| .| |||| .|||.  
nrqnqiipssdrnvpiivhcsagvgrtgtfctavim
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 855-1116 6.6e-90 296.2 In-house 23-290 (297) alignment 
Range on Protein: 855-1116
Range on HMM: 23-290/297.0
MTKEFQTLKSLCPdpPASQTRSGRTPDNQ---PKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGVHCTFMTTQMPLPATVSDFWSMVLNYKPSTI
.  .. . . ||.  |....... . ...   .|.|| | || ...||.|    |.|| ||.||| .||..  ..||||| .||| ||| |||....|||
rhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvsti

VMLNDKSQNDKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRNS-KTSHTVTQYQFHGWPKHGSDQQSGARSLIKLIRAVKGSTNKMNEFSI
|||||....||.||.||..  ...||. ||..||.|    .  |.|..|... |. . | ||||  ||..  ...  |.||.|||  |. . .. .|  .
vmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPl

LVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTENYE
|||||.| ||||||.|  ...|.. . ..||||..|| || .|...|||.|.|.|.| |. |.| .|...
lvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
0046845 (Phosphotyrosine protein) phosphatases II 855-1112 1.3e-72 239.9 In-house 2-276 (284) alignment 
Range on Protein: 855-1112
Range on HMM: 2-276/284.0
MTKEFQTLKSLCPDPPaSQTRSGRTPDNQPKNRYGNNLPLQRNRVILDS-----PDHDYINASQMKGV-------HCTFMTTQMPLPATVSDFWSMVLNY
. .||..| || ...   ... .. | |. |||| . ||. ..||.|.|     .|.|||||| ..|        ...|. ||.||| || ||| ||...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPSTIVMLNDKSQNDK-SCAQYWPNAD-SAQFGSYSVTTLSTSTDGDMTIRKLKITRN--SKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGST
. ..||||..  .|..  ||||||. . . ..| ..||.||. ...|.|.|.|..|..  .. |.|||......|| ||  ..  ...|....|.|. . 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrell

NK-MNEFSILVHCLSGAGRTGVLCTAMECIAQIAERD---SVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHT
..  ..  |.|||  | ||||...... .. |. ...    ||....|| ||  |...|||.| | |.|.|. ||| .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
DSPc_SM00195 855-1110 1.7e-71 236.0 In-house 2-262 (263) alignment 
Range on Protein: 855-1110
Range on HMM: 2-262/263.0
MTKEFQTLKSLCPDPpasQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKG--VHCTFMTTQMPLPATVSDFWSMVLNYKPSTIV
. .||..|..  ..    .|.... . |. |||| | || ...||.|....    .|||||. .||     ..  ||.||| ||.||| ||.. | ..||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKSQ-NDKSCAQYWPNA--DSAQFGSYSVTTLSTSTDG-DMTIRKLKITRNS-KTSHTVTQYQFHGWPKHGSDqqSGARSLIKLIRAVKGSTNKMnE
||.. .. . . |..|||.   .. .||..||.. .. ..  ....|.|..| .  .....|||||...||.|| .  . ..|...|.|||| |...  .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp..dstksvlellravkksksts.s

FSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
  |.|||  | ||||...|.  .. ...| . ||||..|| ||  |.. |||.|.|.|||.|| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 855-1110 1.7e-71 236.0 In-house 2-262 (263) alignment 
Range on Protein: 855-1110
Range on HMM: 2-262/263.0
MTKEFQTLKSLCPDPpasQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKG--VHCTFMTTQMPLPATVSDFWSMVLNYKPSTIV
. .||..|..  ..    .|.... . |. |||| | || ...||.|....    .|||||. .||     ..  ||.||| ||.||| ||.. | ..||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKSQ-NDKSCAQYWPNA--DSAQFGSYSVTTLSTSTDG-DMTIRKLKITRNS-KTSHTVTQYQFHGWPKHGSDqqSGARSLIKLIRAVKGSTNKMnE
||.. .. . . |..|||.   .. .||..||.. .. ..  ....|.|..| .  .....|||||...||.|| .  . ..|...|.|||| |...  .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp..dstksvlellravkksksts.s

FSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
  |.|||  | ||||...|.  .. ...| . ||||..|| ||  |.. |||.|.|.|||.|| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Ptp69D_pd Subfamily Ptp69D 855-1114 7.4e-56 184.5 In-house 24-290 (307) alignment 
Range on Protein: 855-1114
Range on HMM: 24-290/307.0
MTKEFQTLKSLcpdPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGV--HCTFMTTQMPLPATVSDFWSMVLNYKPSTIV
..||...|..        .|. .   .|. |||| .  .  ..||.|       | |||||| .||   . .|.. | |. ||. ||| |. . .  .||
lakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLNDKSQNDK-SCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRNSK------TSHTVTQYQFHGWPkhGSDQQSGARSLIKLIRAVKgSTNKM
|| . .. ..  ||.|||. |  |.|.  |.. |... .| .||.|..... .       |. |.||.. ||.   |     ||.|.|||. |. . .|.
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk..DskvPevargllklieqvr.elykl

NEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
|.  |.|||  |.||.|.. .    . |. . |.||||.||| || .|  .||  | | |.| |. .| .  .
nrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 855-1114 1.4e-42 140.4 In-house 17-297 (301) alignment 
Range on Protein: 855-1114
Range on HMM: 17-297/301.0
MTKEFQTLKSLCPDppasQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSP------DHDYINASQMKGVH--CTFMTTQMPLPATVSDFWSMVLNYKPST
. .....||.  ..    ..  | . .|.. ||. |. ... ||.||          ..||||| ..|.     |. .| |.  |. ||| .....||..
feeqykelkegedk....sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

IVMLNDKSQN-DKSCAQYWPNA--DSAQFGSYSVTTLSTSTDGDMTIRKLKIT----------------RNSKTSHTVTQYQFHGWPKHGSDQQsgARSL
|||. .. ..  ..| |||||.  .| .||  .||  .. .  |..||.|...                ...|.|..|.|.|   ||..|  ..   |  
ivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre..prtv

IKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
.. |  |   ..|..   ..|||  . .|.|| |.    . |      ||.|| .|..|  ..  |.| | | .|||.| .||. ..
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_PTPN13_pd Subfamily PTPN13 856-1111 2.8e-46 153.0 In-house 14-270 (273) alignment 
Range on Protein: 856-1111
Range on HMM: 14-270/273.0
TKEFQTLKSLCpdpPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDHdYINASQMKGV----HCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLN
..||..|. |    |  ....|.. .|. |||| | || .. ||.|..    ||||| .|      . ... .| ||| ||.||| || . | . |.|. 
aeefkelrelk...pldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

-DKSQNDKSCAQYWPNADSAQFGSYS---VTTLSTSTDGDMTIRKLKITR-NSKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTNkmNEFSI
 .| ..   | .|||.  . .   ..   |. | .    ....|.|...  .|. |. |.. .|  || ||  ..  | .|..... |.   .  ..  |
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss..aaellqfvaevrrlqt..dagPi

LVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLH
.||| .| ||.|.| |    .  |.   ..|. ..|..||  |   |||.. | |.| || | |.
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 860-1108 1.5e-20 68.0 In-house 15-267 (281) alignment 
Range on Protein: 860-1108
Range on HMM: 15-267/281.0
QTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDS--P---DHDYINASQMKG--VHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLND
| .  |  |||.        | |. |||| |   |.  || |    |     ||| |  ..   ..  .. || |   | .||| |. . . ..|||| .
qefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

K-SQNDKSCAQYWPN-AD-SAQFGSYSVTTLSTSTDGDMTIRKLKITRNSKTsHTVTQYQFHGWPKHGSDQQSgaRSLIKLIRAVKGSTNkmnefSILVH
    | . ||.|.|  |    ||  .||.   .. .  .   .|... . .| . .|.. .. ||     . |    ..|..| ..  .        ..|
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyeget.rlithwlwkewpdwqvpess..evmlkilrkirarst.....ppvih

CLSGAGRTGVLCTAMECIAQIAER-DSVDIFQTVKTLRA-DRMQFVQTEEEYAFIYDAIRE
| .| ||.| | .   ..  |  .    || | |  ||   |   ||| ..| .|.  . .
csagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 865-1114 6.2e-59 194.7 In-house 31-292 (325) alignment 
Range on Protein: 865-1114
Range on HMM: 31-292/325.0
L-CPDPPASQTrSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGV--HCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQND
|  .| . ...     |.|. |||. | ..|...||.|    |.|. |||||| ..      .|...|.||.||. |.| .||... | .|.||   ...
llpsddgiakk.vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgk

KSCAQYWPNA--DSAQFGSYSVTTLSTSTDGDMTIRKLKITRNSKT-SHTVTQYQFHGWPKHGSDQQSGA-RSLIKLIRAVKGS--TNKMNEFSILVHCL
..||.|||.   .| .||.  |   .  .  |   |.|.. . .|  . .| |.|. .|.  | ...  .  |...|. ||.    .|      ||||| 
drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

SGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
.| |||||. .    .|.. |  .||||. || ||.|| . |.| ..| .||.|. |.. . |
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 867-1115 1.4e-132 436.3 In-house 29-282 (315) alignment 
Range on Protein: 867-1115
Range on HMM: 29-282/315.0
PDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGVHC--TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-S
|||.....|..|...|..||||.|.|||...||.|    ||||.||||||..|.|..  .....|.||.|.|.|||.|||..|..||||...|...|| .
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CAQYWPN--ADSAQFGSYSVTTLSTSTDGDMTIRKLkITRNSKTSHTVTQYQFHGWPKHGSDQQSGarSLIKLIRAVKGStNKMNEFSILVHCLSGAGRT
|.||||.  |||..|||..|..||...|.|...||| .||.|..|.||||.||..||..|.|.|..  ||.|||..||.. |...|||.||||..|.|||
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrt

GVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTENY
||.....|..|||....|||.|..||.|||.|...|||||||||||||..|.|.  | 
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
0045098 (Phosphotyrosine protein) phosphatases II 867-1111 8.2e-62 204.4 In-house 18-273 (278) alignment 
Range on Protein: 867-1111
Range on HMM: 18-273/278.0
PDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVIldspdhDYINASQMKGVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQN-DKSCAQYWP
. .. |.   .  ..|..|||| . ||. ..||.      |||||| ..| . .|  || ||| ||.||| |. ... ..||||..  ..  . ||||||
llgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

NADSAQFGSYSVTTLSTSTDGDMTIRKLKITR-----NSKTSHTVTQYQFHGWPKHGSDQQSGARSLIKLIRAVKGSTN---KM---------NEFSILV
. .| ..| ..||.||... .|.|.|.|..|      .. .|..||......|| ||.  ..  .|...|.. ..   .   ..         ..  .||
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCLSGAGRTGVLCTAMECIAQIaErDSVDIFQTVKTLRADRMQ-FVQTEEEYAFIYDAIREYLH
||  | ||||.|. |. .. .. | . ||....||.||  |..  ||..| | |.|....|.|.
HCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 867-972 9e-35 114.8 In-house 30-150 (392) alignment 
Range on Protein: 867-972
Range on HMM: 30-150/392.0
PDPPASQTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGVHC--TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLND-----KSQ
|.|............|..||||.|.||....||.|    |.||.||.|||.......  .....|.| .|...|||.||.. ...||.|...     | .
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgd

NDKSCAQY----WPNADSAQF
.....||.    ||..|  ..
dartvaqfhftewPdkdvpkh
subfamily_PTPRD_pd Subfamily PTPRD 869-1116 1.1e-71 237.1 In-house 35-287 (564) alignment 
Range on Protein: 869-1116
Range on HMM: 35-287/564.0
PPASQTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGVH--CTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCA
.. ..... . | |..|||| | ..  ..||.|      .. |||||| ..| .   ... || ||. |..||| || ... ||||||.  . ..|  |.
gqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkch

QYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKI-TRNSKTSHTVTQYQFHGWPKHGSDQQSgaRSLIKLIRAVKGSTnKMNEFSILVHCLSGAGRTGVL
.|||. .....|.. ||  .. .  |..||..|. . .|. |..|.|..|  || ||  ..   .||..||| |. .. . ..  |.||| .| ||||. 
kYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa..tslLdlirkvraln.epdagPivVhCSaGVGRTGtf

CTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTENYE
..   .. .| | . |||.|.||.||..|   ||||| |.||..|| |.|.  | |
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_PTPN3_pd Subfamily PTPN3 869-1108 8.4e-49 161.0 In-house 28-273 (280) alignment 
Range on Protein: 869-1108
Range on HMM: 28-273/280.0
PPASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDHDYINASQMK----G--VHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCA
 |  ..   | |.| .|||| . ||    ||.|.. . |||||. ..    .  .   ...|| ||. |..||| || . | |.|||| .  .. .  | 
kpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPN-ADSAQFGSYSVTTLSTSTDGDMTIRKLKITRNS-KTSHTVTQYQFHGWPKHGSDQQSgaRSLIKLIRAVKGSTNKmNEFSILVHCLSGAGRTGV
||||.  |. ..|..||.  .....  . .|.| ..... | .....| |.  || ||  ..|   ....... |.   .  .|  ..||| .| |||||
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdds..adflefvervrklrsg.keePvvvhCsaGigrtGv

LCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIRE
| .   ..| | ....| . . |.|.|  |. .|||.. | |. .|| .
lilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 870-1108 2.6e-49 162.6 In-house 21-264 (283) alignment 
Range on Protein: 870-1108
Range on HMM: 21-264/283.0
PASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDHDYINASQMK-----GVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKS-QNDKSCAQY
|  ..    . .|..|||. . .| ...|| |.|  .|||||. .           .. .| ||  || ||| || . | ..||||     .... |.||
pdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRN--SKTSHTVTQYQFHGWpkHGSDQQSGARSLIKLiRAVKGSTNKMNEFSILVHCLSGAGRTGVLC
||.  | ..| . ||     |   ..|..| .  |  .|..  .. ||. .|     ..|.   ||.|.   |.   .. ..  |.||| .| |||.|..
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW..leygeqaiinslvkf.nkvislqteskkgPivvhCstgiGrtavfi

TAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIRE
.|.  . ..     ||.|..|| .| .||  ||| . | ...... |
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 871-1111 2.1e-50 166.9 In-house 15-257 (284) alignment 
Range on Protein: 871-1111
Range on HMM: 15-257/284.0
ASQTRSgRTPDNQPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGVHC--TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNdksqnDKSCAQYW
. || .   ..|. |||.|. |.  .|.| |.  .     |||||| ..|      ...|| ||. |. ||| |. .|. ||||.|      .. |.|||
tdqtfa.nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqyw

PNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRN--SKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTNKMNE-FSILVHCLSGAGRTGVLC
|.    . . . |   | .   ....|.......   |   ...|. | |||..|  ..  .  |..|.. |.  |.|.|.  .|.||| .|.|||||  
plkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdy..psdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

TAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIRE-YLH
.    . .. | . ||....|. || .| ..||   .| ||| |. | .| 
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_PTPN14_pd Subfamily PTPN14 871-1111 9.6e-44 144.6 In-house 38-297 (300) alignment 
Range on Protein: 871-1111
Range on HMM: 38-297/300.0
ASQTRSGRTPDNQPKNRYGNNLPLQRNRVILDSP---DHDYINASQMK----GVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCAQ
 ... ... |.|..|||. . || . ||| | .    ...|||||..|    | . .....| ||. || ||| || . . . |||| .. .. |  . .
dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPNA----DSAQFGSYSVTTLSTSTDGDMTIRKLKITR-NSKTSHTVTQYQFHGWPKHGSD-QQSGARSLIKLIRAVKGSTNKMNE-----FSILVHCL
|.|.     ....|| . |||  ... . .. ..||.    ||   ||   |.  ||.||     .|  | .. ...|.  ||...|       .||||.
yfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

SGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLH
 |.|||||| ..   || .   ...|| .....||  || .|||   | |.|... .||.
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 872-1113 6.2e-65 214.3 In-house 36-286 (305) alignment 
Range on Protein: 872-1113
Range on HMM: 36-286/305.0
SQTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGVH--CTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLN-DKSQNDKSCAQYW
...  |..  |. |||. .. .|. .|.||      .|.|||||| ..| .   .....| ||. ||.||| .....|.||||||   . .... | |||
esidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYW

PNADSA--QFGSYSVTTLSTSTDGDMTIRKLKITR--NSKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVL
|.. .   .||..||.  |..|  | ..|||||.   ..| |.||.|||.  || ||  |.  | ||..||. |. . .| .. ..||||  | ||||| 
pesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf..atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvf

CTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTE
..    . .. . ..||.|. .|.||  ||. ||| ..| |..||. |.... 
iavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_PTPRA_pd Subfamily PTPRA 873-1111 2.2e-56 186.1 In-house 49-297 (330) alignment 
Range on Protein: 873-1111
Range on HMM: 49-297/330.0
QTRSGRTPDNQPKNRYGNNLPLQRNRVILD----SPDHDYINASQMKGVH--CTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLND-KSQNDKSCAQYWP
        .|. |||. | || . .||||      .. |||||| ..| .   .|...| |.  || ||| |. ..| .||||| . | .... ||||||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

NADSAQFGSYSVTTLSTSTDGDMTIRKLKIT-----RNSKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTNKMNEfSILVHCLSGAGRTGVL
.  .  .|   |.   .    |.|.||. ..     .. |.|  |.|. |..||. |   .  .. ..||...||   ... . .| ||| .|.|||| .
deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe..piGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtf

CTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREY-LH
..    ....     ||.|..|| ||. | | |||.| | ||| ...|| |.
ivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_PTPN1_pd Subfamily PTPN1 873-1108 6e-41 135.1 In-house 23-269 (290) alignment 
Range on Protein: 873-1108
Range on HMM: 23-269/290.0
QTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDHDYINAS--QMKGVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQ-NDKSCAQYWPNADS
.||. ..| |...||| .  | .  |..|.. | ||||||  ... ..  .. || ||| ||. || || . |  ..||||   . .   ||||||. ..
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

---AQFG--SYSVTTLSTSTDGDMTIRKLKITR-NSKTSHTVTQYQFHGWPKHGSDQqSGArSLIKLIRAVKGSTNKM-NEFSILVHCLSGAGRTGVLCT
    ..   ...|. .|. .    |.|.|...  ... ....... .  ||  |  . | | ...|..  |. |     .    ..|| .| ||.| .| 
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpe.spa.aflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

AMECIAQIAERDS---VDIFQTVKTLRADRMQFVQTEEEYAFIYDAIRE
.  |...| ..|    ||| ...  ||  |. ..|| .   | | || |
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 875-1111 3.7e-49 162.3 In-house 21-269 (274) alignment 
Range on Protein: 875-1111
Range on HMM: 21-269/274.0
RSGRTPDNQPKNRYGNNLPLQRNRVIL-----DSPDHDYINASQMKGVH---CTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLND-KSQNDKSCAQYWP
.  . . .| |||| . || .. ||.|     ...| .||||  .|| .    ... || ||| ||.||| |. . . . |||| . | .| . ||.|.|
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

NADSA----QFGSYSVTTLSTSTDGDMTIRKLKITRNSKtSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTNKMNEF--SILVHCLSGAGRTGV
.| ..    ..|  .... .. .  | ..||| .   .. ...|. | .  || | | ..  |..|..|.. |. | .. |.   ...||| .| ||||.
daedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaGiGrtGc

LCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLH
  ..  .. |. |.  ||....|  || ||   |||.| | .|. |. .||.
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
0040439 (Phosphotyrosine protein) phosphatases II 876-1110 9.7e-60 197.6 In-house 5-246 (249) alignment 
Range on Protein: 876-1110
Range on HMM: 5-246/249.0
SGRTPDNQPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGV--HCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQN-DKSCAQYWPNAD
 .. | |..|||| . ||. ..||.| .    ...|||||| ..|     .|  || ||| ||.||| |. ... ..||||..  ..  . ||||||. .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SAQFGSYSVTTLSTSTDGDMTIRKLKITR-NSKTSHTVTQYQFHGWPkhGSDQQSGARSLIKLIRAVKGSTNKM-NEFSILVHCLSGAGRTGVLCTAMEC
| ..| ..||.||. . .|.|.|.|..|.   ..|.||...|...||    .  .   .|...|.||.   ..  ..  .||||  | ||||....|  .
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
. |. ..  ||....||.||  |.. ||..| | |.|.|..|.|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0049772 (Phosphotyrosine protein) phosphatases II 876-1111 8e-31 103.3 In-house 40-281 (314) alignment 
Range on Protein: 876-1111
Range on HMM: 40-281/314.0
SGRTPDNQPKNRYGNNLPLQrNRVILDS---PDHDYINASQMKGVhCTFMTTQMPLPATVSDF----------WSMVL--NYKPSTIVM-----------
 .. . |. |||| . ||   |||||..    ..|||||| ..|. ..|. || ||. || ||          |.|||   ... .|||           
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LNDKSQNDkscaQYWPNADSAQFGsysvttlststdgdmtirkLKITRNSKTSHTVTQYQFHGWPKHGSDQQSGARSLIKLIRAVkgstn
          |.. . |      ... || ...                      .. ... .... .|  . .| .. .  .  ......|...     
rLdaAlgKtpllildgng....neptaadlellk...................eelydpelferlgikylripvpDgsaplledfdeflefieea.....

kMNEFSILVHCLSGAGRTGVLCTAMECIAQIaerdSVDIFQTVKTLRADRM-----QFVQTEEEYAFIYDAIREYLH
  ..  .|||| .| ||||....|. .. .      |.. .... .|. |.      |... |.| ||..|..||| 
.dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 876-1018 3.3e-19 63.9 In-house 27-179 (297) alignment 
Range on Protein: 876-1018
Range on HMM: 27-179/297.0
SGRTPDNQPKNRYGNNLPLQRNRVILD--SPDHDYINASQMK----GVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQND-KSCAQYWPNAD
| . .    |||| . |  . .|| |    ...|||||  .          .. .| || ||| ||| .| .    .|||.    ..  . || |||...
sakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

SAQ--FGSYSVTTLSTSTDG--DMTIRKLKITRNsKTSHTVTQYQFHGWPKHGS
  .   |.. |  ||. .|    . . .|..    . |  |.  || .|| || 
qerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 877-1112 2.6e-63 208.6 In-house 4-244 (250) alignment 
Range on Protein: 877-1112
Range on HMM: 4-244/250.0
GRTPDNQPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGVHC--TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDKSCAQYWPNADSA
.. |.|. |||| . ..|.  ||.| . .     |||||| ..| .   .|..|| ||.||. ||| |||..| .|||||.. ....| . ||||   . 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

QFGSYSVTTLSTSTDGDMTIRKLKITRNSKTSH-TVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQ
..|.  |. ||. . .|.|.||||.....|... .| |..|  ||  |  ..  |.. ..|.. |. | .. ..  ..|.| .| ||.|  ..    . .
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPev..atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHT
. .   ||.|. .|.||.||.. |...| | |.| .| ..| .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0042113 (Phosphotyrosine protein) phosphatases II 877-1110 2.3e-58 192.8 In-house 4-243 (245) alignment 
Range on Protein: 877-1110
Range on HMM: 4-243/245.0
GRTPDNQPKNRYGNNLPLQRNRVILDSPD----HDYINASQMKGV--HCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCAQYWPNADS
.. | |..|||| . ||. ..||.| ...    .|||||| ..|     .|  || ||| || ||| |. ... .|||||..   ...  ||||||. .|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

AQFGSYSVTTLSTSTDGDMTIRKLKITR-NSKTSHTVTQYQFHGWPKHGSDQ-QSGARSLIKLIRAVKGStnkMNEFSILVHCLSGAGRTGVLCTAMECI
 ..| ..||.||. ...|.|.|.|..|.  .. |..|..|....|| ||     .   ......| .  .    ..  .||||  | ||||....|  ..
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfiaaylml

AQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
 |. ..  |.....|| ||  |.. |||.. | |.|.|..|.|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 877-1110 2.3e-56 186.4 In-house 5-242 (243) alignment 
Range on Protein: 877-1110
Range on HMM: 5-242/243.0
GRTPDNQPKNRYGNNLPLQRNRVILdsPDHDYINASQMKGVHcTFMTTQMPLPATVSD----FWSMVLNYKPSTIVMLNDKS-QNDKSCAQYWPnaDSAQ
.. | |..|||| . ||. ..||.|  ...|||||. ....  ..  ||.||| || |    || |. ... ..||||..    . . ||||||  .. .
allpenlsknrysdilpydhsrvkl..egsdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevt

FGSYSVTTLSTSTDGDMTIRKLKITR--NSKTSHTVTQYQFHGWPKHGSDQ-QSGARSLIKLIRAVKGST----NKMNEFSILVHCLSGAGRTGVLCTAM
.| ..||.||... .|.|.|.|....   .. ...|..|....|| ||  .  .   .... .|..  ..    .  ..  .||||  | ||||.|..| 
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

ECIAQIaerdSVDIFQTVKTLRADRMQ-FVQTEEEYAFIYDAIREYL
 .. ..    .||....||.||. |..  |||.. | |.|.|..|.|
lmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 877-1108 2.9e-50 166.0 In-house 44-277 (315) alignment 
Range on Protein: 877-1108
Range on HMM: 44-277/315.0
GRTPDNQPKNRYGNNLPLQRNRVIL----DSPDHDYINASQMKGVH--CTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDKSCAQ-YWPNAdS
 .   |. |||| | ..  . || |      |. ||.||. ..|      ....| |..|.| ||| .| ... ..||||..  ...|. |. |||.   
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

AQFGSYSVTTLSTSTDGDMTIRKLKITRNSKTsHTVTQYQFHGWPkhGSDQQSGARSLIKLIRAVKGStNKMNEFSILVHCLSGAGRTGVLCTAMECIAQ
  .| ..||  |     ..|.| | .. ...  ..| |...  ||   ..    . .|..||| ||   .. .  .|.||| .| |||| ..|    . |
viyGkitvtrkseevnteytvrtlsvvfgdni.revvqlhytswp..dmgvpkytiplmnlirtvkqh.htnsvgaivvhcsaGvGrtGtfitldavldq

IAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIRE
.   . .|... .. .|. |.. ||. |.| |||||. |
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_eak_pd Subfamily eak 877-1114 8.1e-17 55.6 In-house 47-309 (332) alignment 
Range on Protein: 877-1114
Range on HMM: 47-309/332.0
GRTPDNQPKNRYGnNLPLQRNRVILDSPD---HDYINASQMK--GVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQND-KSCAQYWPNAD--
..  ..  .| ..  .| .|. | | |       ||||| ..   |   .. | ..    |  || |||. |  .||.| .. ... .   .|.|.    
tarleavnrnvvk.ivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktre

SAQFGSYSVTTLSTSTDGDMTIRKLKITRNSKTsHTVTQYQFHGWPKHGS------------DQQSGARSLIKLIRAVKGSTNKM-----NEFSILVHCL
  .|| . |.. .    . .  |.|....  .| | |  |...|| .                .. |.  ||    |.  || |        |. .. . 
elkfGildverkefvkrniletrllelskGnet.hrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsa

SGAGRTGVLCTAMECIAQIAER--DSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
 |. |.||.      |  | ..  ..  . . .   .  |.  | .. ...|||... .|| . |
rGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_PTPRK_pd Subfamily PTPRK 878-1108 6.2e-60 197.7 In-house 39-275 (314) alignment 
Range on Protein: 878-1108
Range on HMM: 39-275/314.0
RTPDNQPKNRYGNNLPLQRNRVILDSPDHD----YINASQMKGVHC--TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQND-KSCAQYWPNADSA
.  .|. |||.|. |.  | ||.| . | |    ||||. . . .    |. || ||. || ||| .|.... ..||||..  ..    | .|||.  . 
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

qFGSYSVTTLSTSTDGDMTIRKLKITR---NSKTSHTVTQYQFHGWPKHgsDQQSGARSLIKLIRAVKGSTNKmNEFSILVHCLSGAGRTGVLCTAMECI
 .|   |. ..|... .. .| .....   . .  ..| |.|| |||.|  |    |..|.||.| || |... ..  |.|||..||||||. ..    .
.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

AQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIRE
  | ... ||.|..|||||. .. .|.||| | ||||.| |
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 878-1112 2.1e-21 71.0 In-house 44-289 (305) alignment 
Range on Protein: 878-1112
Range on HMM: 44-289/305.0
RTPDNQPKNRYGNNLPLQRNRVILDSP-DHDYINASQMKG--VHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVML-NDKSQNDKSCAQYWPNADSA--Q
.  ... |||| .   |..||| |..|  |.|| |  .        |. || ||  | .||| | |. |  .| || | . .  | |..|..  |    .
keaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

F-----------GSYSVTTLSTSTDGDMTIRKLKITRNSKTSHTVTQYQFHGWPKHGSDQqsGARSLIKLIRAVKGSTNkmnefSILVHCLSGAGRTGVL
|            | .   . .... ..|  .| |    .... ||.| .  ||  |        ....|.   . |        | ||| .| |||| .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa..adlailellekarpskg.....pivvhcsagigrtgsv

CTAMECIAQIAERDSVDIF-QTVKTLRADRMQFVQTEEEYAFIYDAIREYLHT
      . |. . . ..   . .. .| .| . .||...| |... | .|.. 
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_CG42327_pd Subfamily CG42327 879-1035 2.7e-18 60.7 In-house 25-191 (319) alignment 
Range on Protein: 879-1035
Range on HMM: 25-191/319.0
TPDNQPKNRYGNNLPLQRNRVILDS----PDHDYINASQMKGV---HCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQND-KSCAQYWPNADS-
 .  ..|.|. | .||   ||.|..    .   |..|| ..|    .. ....|..|  . |||| .| . .  .|| | | |..  | ||.|.|  .. 
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

---AQFGSYSVTTLSTSTDGDMTIRKLKITRNS-KTSHTVTQYQFhGWPKHGSdqQSGARSLIKLIRAVK
     .| . ||     ..    |  | . |   . |  .| | .  |.. .    .  ..|| ..  |.
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaev..Paeeaaliamllevr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 881-1107 7.6e-40 131.6 In-house 2-236 (237) alignment 
Range on Protein: 881-1107
Range on HMM: 2-236/237.0
DNQPKNRYGNNLPLQRNRVILDSP--DHDYINASQMKGVHC---TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDK-SQNDKSCAQYWPNADS-AQFG
.|. ||||||    . .||.|  .  . |||||. .||.     .....| || ..  ||| || . | | ||||     .|.. | .|||..|  | .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SYSVTTLSTSTDGDMTIRKLKITRNS--KTSHTVTQYQFHGWPKHGSDQQSGArsLIKLIRAVKG-STNKMNEFSILVHCLSGAGRTGVLCTAMECIAQI
 ..|.        | |.| | ....   |    . ||||  ||..|  ||. |  |... . .   |    .    ..|| .| ||||..      . | 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

AERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIR
 |.  |||.. |...  ||   .||...| ||...| 
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 881-1119 1.1e-15 52.0 In-house 46-288 (303) alignment 
Range on Protein: 881-1119
Range on HMM: 46-288/303.0
DNQPKNRYGNNLPLQRNRVILDspDHDYINASQMK-GVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDKSC-AQYWP-NADSAQFGSYSV
.|  |||. . . |.  .| |   |  || || ..   .   . ||.||. | .||| |... |   ...|   |. ||      .| | |  .|   |.
knmdknrfvdvicldhskvkls..dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersi

TTLSTSTDGDMTIRKLKITR--NSKTSHTVTQYQFHGWPkHGSDQQSGARSLIKLIRAVKGSTNKMNEFSILV-HCLSGAGRTGVLCTA-MECIAQIAER
          .   .||.    | .    .  .... || |.|    |.  ..| |  ..    |  . .  |   ||| ||.| ..      ..  .|.
rvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawp.hnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseq

DSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTENYEQLP
 |.|. . ....|  |.. ||   .....|  . |..  . . .| 
asldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickla
Y_phosphatase Protein-tyrosine phosphatase 882-1106 3.1e-65 215.3 Pfam-A 1-233 (235) alignment 
Range on Protein: 882-1106
Range on HMM: 1-233/235.0
NQPKNRYGNNLPLQRNRVIL-DSPD-HDYINASQMKGV--HCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQ-NDKSCAQYWP--NADSAQFGS
|. |||| . || ...|| | .|.. .|||||. .||   . .|. ||.||. |..||| ||...| ..||||..  . ... ||||||  . .| ..|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVTTL-STS-TDGDMTIRKLKITRNSKT--SHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTnKMNEFSILVHCLSGAGRTGVLCTAMECIAQI
..|..  ...  . ..|.|||... . .   ...|.|.....||.||  ..  ..||..|||.|. |. . .. ...|||  |.||||...... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAI
 ....||..|.||.||. |.. ||..|.|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 882-1106 3.1e-65 215.3 In-house 1-233 (235) alignment 
Range on Protein: 882-1106
Range on HMM: 1-233/235.0
NQPKNRYGNNLPLQRNRVIL-DSPD-HDYINASQMKGV--HCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQ-NDKSCAQYWP--NADSAQFGS
|. |||| . || ...|| | .|.. .|||||. .||   . .|. ||.||. |..||| ||...| ..||||..  . ... ||||||  . .| ..|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVTTL-STS-TDGDMTIRKLKITRNSKT--SHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTnKMNEFSILVHCLSGAGRTGVLCTAMECIAQI
..|..  ...  . ..|.|||... . .   ...|.|.....||.||  ..  ..||..|||.|. |. . .. ...|||  |.||||...... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAI
 ....||..|.||.||. |.. ||..|.|.|.|.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 882-1113 3.5e-46 152.4 In-house 20-267 (270) alignment 
Range on Protein: 882-1113
Range on HMM: 20-267/270.0
NQPKNRYGNNLPLQRNRVILDS----PDHDYINASQMK---GVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLND-KSQNDKSCAQYWPNADSA---
..  ||| . ||  . ||.|..    .   ||||  ..   | ........ |||.|...|| |... | ..|||. . . .. | |..|||.       
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-QFGSYSVTTLSTSTDGDMTIRKLKITRNSKTsHTVTQYQFHGWPKHGSDQQSG----ARSLIKLIRAVKGSTNKMNEF-SILVHCLSGAGRTGVLCTAM
 ..|  .|..||.. .    ...|........ . .. .... || ||  ....    ...|.|..|||. |......   .||||  | ||||.| .  
ledgkikvlalseekeegyiltrlrleekgee.rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

ECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTE
 ..  . |. .||. . .. || |||..||. |.|.|.| |..|| .. 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
0041856 (Phosphotyrosine protein) phosphatases II 882-1115 2.3e-37 123.7 In-house 1-176 (182) alignment 
Range on Protein: 882-1115
Range on HMM: 1-176/182.0
NQPKNRYGNNLPLQRNRvildspDHDYINASQMKGVHCT--FMTTQMPLPATVSDFWSMVLNYKPSTIVMLNdksqndksCAQYWPnadsaqfgsysvtt
|..|||| . ||  ..|      | |||||. . | . .  |  || ||. || ||. |. ... .|||.|.        . .|||              
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..............

lststdgdmtirklkitrnSKTSHTVTQYQFHGWPKHGSDQqsgARSLIKLIRAVKGstnkmNEFSILVHCLSGAGRTGVLCTAMECIAQiaerdSVDIF
                   ..  ....||....|| ||       ..|...|..|.      ..  .||||  | ||||.|. |  .. .     .|...
...................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

QTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTENY
..||..|  |.. |.|.. | |...|..|.|.  ..
eavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 882-1108 8.8e-33 108.4 In-house 7-238 (239) alignment 
Range on Protein: 882-1108
Range on HMM: 7-238/239.0
NQPKNRYGNNLPLQRNRVILD----SPDHDYINASQMK---GVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQ-NDKSCAQYWPNADSaQFG
|. |||| | .  ...||.|.     |  |||||| ..   |   ....||  . ..  ||| |. . .   ||||    .   | | ||||.. | .. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

SYSVTTLSTSTDGDMTIRKLKITRNSKTSH-TVTQYQFHGWPKHGSDQQSGArsLIKLIRAV-KGSTNKMNefSILVHCLSGAGRTGVLCTAMECIAQIA
   ||   |    |  || . ...  .|    | ||.|  || .|  | . |  .. | | . | |         ..|| .| |||| .      . |  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata..vlglrrkitkdslpgar..pwvihcsagvgrtgaflvidamlrqak

ERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIRE
.. .||||. ||..| || ..||| |.| ||. |. |
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 882-1107 9.9e-33 108.3 In-house 8-238 (239) alignment 
Range on Protein: 882-1107
Range on HMM: 8-238/239.0
NQPKNRYGNNLPLQRNRVILD----SPDHDYINASQMK---GVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQ-NDKSCAQYWPNADSaQFG
|. |||| | .  ...||.|.     |  |||||| ..   |   ....||  . ..  ||| |. . .   ||||    .   | | ||||.. | .. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

SYSVTTLSTSTDGDMTIRKLKITRNSKTSH-TVTQYQFHGWPKHGSDQQSGArsLIKLIRAV-KGSTNKMNefSILVHCLSGAGRTGVLCTAMECIAQIA
   ||   |    |  || . ...  .|    | ||.|  || .|  | . |  .. | | . | |         ..|| .| |||| .      . |  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyata..vlglrrkitkdslpgar..pwvihcsagvgrtgaflvidamlrqak

ERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIR
.. .||||. ||..| || ..||| |.| ||. |. 
kqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 882-1113 2.9e-28 93.7 In-house 35-273 (285) alignment 
Range on Protein: 882-1113
Range on HMM: 35-273/285.0
NQPKNRYGNNLPLQRNRVILDSPDHDYINASQMKG---VHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQN-DKSCAQYWPNA--DSAQFGSY
|   ||| .   ..  ||.|   |.||| || |.     . |..||| ||| |.|||| |. . | . ..||    .   . || |.|.   .  .|| |
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

SVTTLSTSTDG-DMTIRKLKITRNSKTSHTVT----QYQFHGWPKHGSDqqSGARSLIKLIRAVKGSTNKmnEFSILVHCLSGAGRTGVLCTAMECIAQI
 .|      .    || .     |.. . .      . |   || . .     || .|.| . ||    |  |  | ||| .| |||  .     .  .|
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlap..edarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatiri

AERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTE
 |   ..... |. .|| |.| ||.  .. |.|  . ||.  |
menpniemldivremramrfqavqshmqflflyvvlmeyfige
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 882-1117 1e-23 78.8 In-house 43-278 (288) alignment 
Range on Protein: 882-1117
Range on HMM: 43-278/288.0
NQPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGVHC--TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCAQYWPNA--DSAQFGSYS
|  ..|| |       || |.   . ||.|  .   .    .. .| || .|.  .| |.|.     ||||..  .  |   |.|.|    ..|..| . 
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlc

VTTLSTSTDGDMTI--RKLKITRNSKTSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVkgstnKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERD
  .    .| | ..    |.|... ...  | .  .. |...|  ..    | ..|.  .     |  .  |.||.  |.|||| |   .  . ..   |
tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen..ylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrldd

SVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTENYEQ
 . | . .. ||..|.. .|||  | ...  . |.|    |..
flgirsllaklreerfkaiqtemqylyvhrcvleelllkkykv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 882-1112 6.1e-18 59.3 In-house 51-287 (302) alignment 
Range on Protein: 882-1112
Range on HMM: 51-287/302.0
NQPKNRYGNNLPLQRNRVILDSPDHDYINASQMKGVHC--TFMTTQMPLPATV---SDFWSMVLNYKPSTIVMLNDKSQNDKSCAQYWP--NADSAQFGS
|  ||.  .   |. |.|.|.    .|.|||...  ..  . . .|.|   ..    .|| || . |  ..|.|  . . .|.  ...|    |  ..|.
nlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygk

YSVTTLSTSTDGDMTiRK--LKIT-RNSKTSHTVTQYQFHGWPKHGSDQQSGarSLIKLIRAVKGSTNKMNEFSIlVHCLSGAGRTGVLCTAMECIAQIA
  | .   .   ...  .  . .   .   |  .. | .. |...   .. .  .||| .  |  .. | .| .. .    |||| |.. |..  . .. 
mfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkya..eliktaakvfakkikadentv.ivSknGaGRagafltlavaveklq

ERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHT
. . . | ..||..|..| . |.. . |...| |.  |. .
kgkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 882-1104 7.9e-16 52.5 In-house 52-284 (310) alignment 
Range on Protein: 882-1104
Range on HMM: 52-284/310.0
NQPKNRYGNNLPLQRNRVIL---DSPDHDYINASQMKG--VHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCAQYWPNADS-AQFGS
.  |||| . . |.  || |    |  .||| |  .|   .  ||. .| ||  |. ||| |... .  .|..|   ... .  |  |||       .| 
ymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygc

YSVTTLSTSTDgDMTIRKLKITRNSK-----------TSHTVTQYQFHGWPKHGSDQQSGARSLIKLIRAVKGStnkmnefSILVHCLSGAGRTGVLCTA
  || || |.. .. | .| .|                   |.  ..  ||  |  ..       .|.  |.           .||| .| .|..|... 
irvtnlsesse.efeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg.......pcvvhcsagkdrlyvvval

MECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYD
   | .. . . ||. . .  |. .|.. .||| .| .|  
klkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 884-1114 1.3e-17 58.5 In-house 45-280 (312) alignment 
Range on Protein: 884-1114
Range on HMM: 45-280/312.0
PKNRYGNNLPLQRNRVILDSPDHDYINASQMKGVH--CTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQ-NDKSCAQYWPNAD-SAQFGSYSV--
  ||| |    .| |  |   .  || |  .| .     |..|| ||  |.. || ..|.   ..|..|    .   . ||.|  .     ..  . |  
dlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyt

---TT--LSTSTDGDMTIRKLKITRNS-KTSHTVTQYQFHGWPKHGSDQQSgaRSLIKLIRAVKGSTNkmnefSILVHCLSGAGRTGVLCTAMECIAQIA
   |   .   .   .| | ||.  ..      . .||.  || ||  .     .  .|. |||   .      .. || .| |||| |.     || . 
eycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdsc..dtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalr

ERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTEN
     .. ..   || || . |..  .| .   .. |.|... 
hprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 884-970 3.4e-14 47.3 In-house 49-156 (350) alignment 
Range on Protein: 884-970
Range on HMM: 49-156/350.0
PKNRYGNNLPLQRNRVILD----S--------PDHDYINASQMKGV------HCTF--MTTQMPLPATVSDFWSMVLNYKPSTIVMLND-KSQNDKSCAQ
 |||| | ||  ..||.|     |           |||||. .|           |  . || ||| || ||. ..|. |   |..|..   .| . | .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPNADSA
||.. .  
YWqegsyd
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 893-1018 2.1e-10 35.0 In-house 4-126 (130) alignment 
Range on Protein: 893-1018
Range on HMM: 4-126/130.0
PLQRNRVIldspDHDYINASQM--KGVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDkscaQYWPNADSAQFGSYSVTTLSTSTDGDMTI
. . .|.     ...||||| .   |    .. || || .|  ||| |.|.     .|.|    ..|    .|||...  ..    ..  .|  |.   |
efevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefkni

R--KLKITRNSKTSH-TVTQYQFHGWPKHGS
.  .|.| .. . || ..| .|   ||  |.
kasnleiesdlneshqaltmfqisnwpsdgt
0044763 (Phosphotyrosine protein) phosphatases II 895-1110 4.2e-20 67.6 In-house 3-171 (178) alignment 
Range on Protein: 895-1110
Range on HMM: 3-171/178.0
QRNRVILDSPDH----DYINASQMKGVhcTFMTTQMPlpatvSDFWSMVLNYKPSTIVMLNDKSQND-KSCAQYWPNADSaqfgsysvttlststdgdmt
 |.||.|... .    ||||||.. .    ..... |     .|.. .. ... ..||.|..   .   .| .|||   .                    
drtrvllsnleglersdyinaseilpg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag....................

irklkitrnsktshtvTQYQFHGWPKHGSDQ-QSGARSLIKLIRAVKGSTNkmneFSILVHCLSGAGRTGVLCTAMECIAQiaerdSVDIFQTVKTLRAD
                 ||.. ..| ||  .  .  . ....|...  . .      .||||  | ||.|.|. |  .. .     ...... .. .|. 
................iqylhipipDhgvpdllehflefvefieealdekg....gpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RMqFVQTEEEYAFIYDAIREYL
|. .|.... . ..|.  ...|
Rp.ivpnpgqlrqLyefelrll
0046846 (Phosphotyrosine protein) phosphatases II 897-1110 1.8e-28 94.9 In-house 3-173 (176) alignment 
Range on Protein: 897-1110
Range on HMM: 3-173/176.0
NRVILDSPDHDYINASQMKGvhCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKS-QNDKSCAQYWPNADSAQFgsysvttlststdgdmtirklki
 |.. . .| |||||. . |  . . .|| ||| |. ||. |..... ...|.|..    .  .|..|||   ....                       
lrllgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

trnsktshtvtQYQFHGWPKHGSDQQSGARSLIKLIRAVKGSTnkmneFSILVHCLSGAGRTGVLCTAMeciaQIAERDSVDIFQTVKTLRADRM-QFVQ
           ||....|| ||  . .   .|...|| .  .        .||||  | ||||.|. |      .  .  ..........|. |. . ||
...........qylhlpwpDhgvpdlelllellefirealkeg.....gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

TEEEYAFIYDAIREYL
|.| | |.|......|
tpeQyrflyefellll
subfamily_egg_pd Subfamily egg 902-1107 6.5e-20 66.0 In-house 68-267 (307) alignment 
Range on Protein: 902-1107
Range on HMM: 68-267/307.0
DspdhDYINASQMKG--VHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNdKSCAQYWPNA--DSAQF--GSYSVTTLSTST--DGDMTIRKL
|    |.| | ..||  .  .|. .| ||  || ||| || . .   ||||. . .. . |  |||.|  ||...  ||. ...|      |  ... ||
d....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtkl

KITRNSKTSHTVTQYQFHgWpkhgsDQQSGARSLIKLIRAVKGSTNkmnefSILVHCLSGAGRTGVLCTAMECIAQIAER--DSVDIFQTVKTLRADRMQ
|.    .    .  .|   .     .. |   | ....| ..  ..      ..|..  |  ....| ..   . ..         . ..|. ||  |  
klvGgddeerflehwqgd.v.....nnssdvysplrvlrklrnlsk.....pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrl

FVQTEEEYAFIYDAIR
 |..   | |.|  . 
svesvllylfvyrlvl
0043147 (Phosphotyrosine protein) phosphatases II 904-1103 3.3e-27 90.7 In-house 3-154 (172) alignment 
Range on Protein: 904-1103
Range on HMM: 3-154/172.0
PDHDYINASQMKGVHCT--FMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKsqndkscaqywpnadsaqfgsysvttlststdgdmtirklkITRNSKT
...|||||| .......  |  || ||. |..||| |. ... ..||.|..                                           .  .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpell

SHTVTQYQFHGWPKHGSDQQSGARSLIKLIRAVKgstNKMNEFSILVHCLSGAGRTGVLCTAMECIaqiaerDSVDIFQTVKTLRADRMQFVQTEEEYAF
.... ||....|| ||    .  ......|. .    .. ..  .||||  | ||||.|. |  ..       .......|...|. |.. ||... | |
erlgiqylylpwpDhgvpllellleflefidell...alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IY
.|
ly
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 904-963 1.2e-07 25.6 In-house 68-128 (347) alignment 
Range on Protein: 904-963
Range on HMM: 68-128/347.0
PDHDYINASQMKG--VHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDkSQNDKSCAQY
. . |||||..|    .  .. || ||| || ||| ||   | . .| . .  ..|..  ..
dvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife.pikdeaieef
0051082 (Phosphotyrosine protein) phosphatases II 905-1106 5.5e-26 86.4 In-house 2-149 (151) alignment 
Range on Protein: 905-1106
Range on HMM: 2-149/151.0
DHDYINASQMKGVhctFMTTQMPLPatvsDFWSMVLNYKPSTIVMLNDKSQNDkSCAQYWPNADsaqfgsysvttlststdgdmtirklkitrnsktsHT
  ||||.|.. |    .  ...||.    ||. .. ... .|||.|...  ..  |..|.|...                                  ..
lsdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg..................................ie

VTQYQFHGWPKHGSDQQ-SGARSLIKLIRAvkgstnkMNEFSILVHCLSGAGRTGVLCTAMECIAQiaerdsVDIFQTVKTLRADRMQFVQTEEEYAFIY
|.......|| .| ..    ......|...       ...  .|||| .| ||||.|. .. .. .      |....... .|. |. .||..... |..
vlhipildwpdpglplsfdavleflellld.......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DAI
 |.
fal
0051429 (Phosphotyrosine protein) phosphatases II 906-1112 1.1e-37 125.5 In-house 4-227 (272) alignment 
Range on Protein: 906-1112
Range on HMM: 4-227/272.0
HDYINASQMKGVhCT------FMTTQMPLPATVSDFWSMvLNYKPSTIVMLNDKSQND-KSCAQYWP------------NADSAQFGSYSVTTLSTSTDG
 .||||. ..|  .       .  ...|||.|. ||| .  ... .|||.| . .  .   | .|||             | .  .| ..||.||...  
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DMTIRKLKITRN--SKTSHTVTQYQFHGWPKHGSDQQSgARSLIKLIRAvkgstnkmnEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVD-------
|...|.| .|.    .....|.......|| ||  |..  ..|..|...         .  .|||| .| .|||... .  ..... . . ||       
dyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHT
 ....|. ||| |...||||| |.|.|.|..|.| .
yleeaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 906-1104 2.3e-29 97.7 In-house 2-164 (174) alignment 
Range on Protein: 906-1104
Range on HMM: 2-164/174.0
HDYINASQMKGVHCT--FMTTQMPLPatvsdFWSMVLNYKPSTIVMLNDKSQND-KSCAQYWPNadsaqfgsysvttlststdgdmtirklkitRNSKTS
.|||||| ......|  .  .| ||.     || |. ... .|.|||..  ...   | .|||                               . .  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

HTVTQYQFHGWPKHGSDQQSGarsLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAeRDSVDIFQTVKTLRADRMQFVQTEEEYAFI
... ||.. .|| ||    |    |......|.   .. ..  .||||  | ||||.|. |. .. ..   . ||....|..||  |.. |||.. | |.
rlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YD
|.
yy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 906-1106 1.3e-22 75.3 In-house 46-255 (290) alignment 
Range on Protein: 906-1106
Range on HMM: 46-255/290.0
HDYINASQMKGVH-CTFMTTQMPLPA-------TVSDFWSMVLNYKPSTIVMLNDKSQNDK-----SCAQYWPNAD--SAQFGSYSVTTLSTSTDGDMTI
 ||| |....  .   .. || |. .       |. .|| |. . |   .||| . .....     .||.| |..   . .|.  .|   |  .. |. .
ddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

RKLKITRNSKTSHTVTQYQFHGWPKHgsDQQSGARSLIKLIRAVKgstnkMNEFSILVHCLSGAGRTGVLCTAMECIAQIA-ERDSVDIFQTVKTLRADR
|.| .. . .  .||| ....|| |     |   ..|..||. ||      ..  ..|||  |  |  .| .       ||  ..|| . . .|.||  |
RelvvkfddeeeftvtHsllkgWnkl..nvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

MQFVQTEEEYAFIYDAI
 . .....|.||.  .|
alaitsalelafvdagi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 906-968 4.3e-09 30.1 In-house 90-157 (349) alignment 
Range on Protein: 906-968
Range on HMM: 90-157/349.0
HDYINASQMK----GVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLN-DKSQNDKSCAQYWPNAD
.|||||  .|     |.  ...||.|||.|| ||. ..|. .   .. || || .. . | .|| . .
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 914-1099 2.1e-24 80.8 In-house 85-270 (301) alignment 
Range on Protein: 914-1099
Range on HMM: 85-270/301.0
MKGVHCTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQ-NDKSCAQYWPNADS--AQFGSYSVTTLSTST--DGDMTIRKLKITRNSK--TSHTVT
 .|    |..|| ||..|  ||| |.  |.  .||||  | . . . |..| |   |   . | ..... .. .  . ... |.|...  ..  ...|||
tsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvt

QYQFHGWPKHGSDQqsGARSLIKLIRAVKGSTNkmnefSILVHCLSGAGRTGVLcTAMECIAQIAERD-SVDIFQTVKTLRADRMQFVQTEEEY
 ||.. |...|  .  .   | .|.  || | .      |.||| .| ||.  .  . |..|.  | |  ... ...| || .| . |||..  
hyqysewtdrgvPk..shaelfdlmelvkksek.....PivvhcsaGiGrsvaf.igteylareveadptieltealkhlrehrwngvqtnsql
0049260 (Phosphotyrosine protein) phosphatases II 919-1104 9.9e-25 82.4 In-house 9-144 (152) alignment 
Range on Protein: 919-1104
Range on HMM: 9-144/152.0
CTFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCAQYWpnadsaqfgsysvttlststdgdmtirklkitrnsktshtvtQYQFHGWPKHG
  |. || |.| |..||| |. ... .|||||.. . ..|  |.||.                                          ||... || ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhg

SDQQSGARSLIKLIRAVKgstNKMNEFSILVHCLSGAGRTGVLCTAMECIaqiaerDSVDIFQTVKTLRADRMQFVQTEEEYAFIYD
  . |     . |.       .. ..  .||||  | ||||.|. |  ..        |.....|. .|. |.. |.... . |.|.
vpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 920-1104 1.5e-23 78.0 In-house 5-197 (198) alignment 
Range on Protein: 920-1104
Range on HMM: 5-197/198.0
TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCAQYWPNADS--AQFGSYSVTTLSTSTDGDMTIRKLKITRNSKT---SHTVTQYQFHGW
 ...|| ||  |..||| || .     |||.||  .| .   . ||| ..|  ...|| |||| . .|  |.||  | .| |. .   .  ...|||  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHGSDQQSGARSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAE--RDSVDIFQTVKTLRADRMQFVQTEEEYAFIYD
 .. . . .    ..   | |    .. ..  ..|||  | | |||. .    .    |     ||.|.  | ||  |   . . . | |||.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 920-1104 1.6e-23 78.0 In-house 6-198 (199) alignment 
Range on Protein: 920-1104
Range on HMM: 6-198/199.0
TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDKSQNDK-SCAQYWPNADS--AQFGSYSVTTLSTSTDGDMTIRKLKITRNSKT---SHTVTQYQFHGW
 ...|| ||  |..||| || .     |||.||  .| .   . ||| ..|  ...|| |||| . .|  |.||  | .| |. .   .  ...|||  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHGSDQQSGARSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAE--RDSVDIFQTVKTLRADRMQFVQTEEEYAFIYD
 .. . . .    ..   | |    .. ..  ..|||  | | |||. .    .    |     ||.|.  | ||  |   . . . | |||.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 920-985 1.5e-15 51.5 In-house 237-301 (440) alignment 
Range on Protein: 920-985
Range on HMM: 237-301/440.0
TFMTTQMPLPATVSDFWSMVLNYKPSTIVMLNDksQNDKSCAQYWP-NADSAQFGSYSVTTLSTSTD
.|..||||| .|| ||| .| .|. |||.|||.   |||.|. ||| |. |  || ..|    .   
afiatqmpldstvldfwrlvhdyristiimlnq..lndktcsiywpvntrsvtfgpftvghkgsenm
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 924-1110 4.5e-08 26.1 In-house 123-309 (346) alignment 
Range on Protein: 924-1110
Range on HMM: 123-309/346.0
TQMPLPATVSDFWSMVLNYKPSTI-VML-NDKSQNDKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRNSKTSHTVTQYQFHGWPKHgSDQQ
 ||   . | ||| |. . .   . .|. .|| .|  .      |      |   .    .   ||     ...  . ..   . | . |   ||  .| 
pqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkh.lqqp

SGARSLIKLIRAVKgSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
  .  .||.|   . | .....  . |  | |.||.  .  |.  | |. .    .|.. .|... .|   |..  .|| ||  . .|.
pktlpiikmihqfl.sekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 926-1102 1.3e-17 58.2 In-house 98-280 (302) alignment 
Range on Protein: 926-1102
Range on HMM: 98-280/302.0
MPLPATVSDFWSMVLNYKPSTIVMLND-KSQNDKSCAQYWPNA--DSAQFGSYSVTTLSTSTDGD-------MTIRKLKITRN---SKTSHTVTQYQFHG
.|   |.  .|... .|. . .| | . . ...| ||.|. .   .  .|| |.|.|.|  || .       ... ...|. .   .|. .||   .| .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPKHGSDQQSgaRSLIKLIRAVKgsTNKMNefsILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFI
||.||. ...   . .....  .  . | |   .||||  | |||| | .    |   ....  |. . |. .|. |   ||.|.   ..
wpdhGapkea..ytaldilkfce..sykkn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 929-1101 7.1e-17 56.2 In-house 44-218 (263) alignment 
Range on Protein: 929-1101
Range on HMM: 44-218/263.0
PATVSDFWSMVLNYKPSTIVMLNDKSQN-DKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITR---NSKTSHTVTQYQFHGWPKHGSDQQsgA
  |.  |....   |....||| |   .  . | .|.|     .     |.  .| .  |. .. |...    . |. |||..|.. ||...   ..  |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpel..a

RSLIKLIRAVKGStnKmnefSILVHCLSGAGRTGVlCTAMECIAQ-----IA--ERDSVDIFQTVKTLRADRMQFVQTEEEYAF
|. .........|  |    |. ||| .| ||.    . .| . |     .   .   .|  . .. ||  | . ..|    ||
reilnilkvarns..k....slvvhcstGiGrsaa.fsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 931-1104 3.7e-18 60.5 In-house 40-215 (255) alignment 
Range on Protein: 931-1104
Range on HMM: 40-215/255.0
TVSDFWSMVLNYKPSTIVMLNDKSQ-NDKSCAQYWPNADSAQFGSYSVTTLSTSTDGDMTIRKLKITRN---SKTSHTVTQYQFHGWPKHGSDQQsgARS
||  |. ..   |....||| |  . . . | .|.|     .     |.  .| .  |. .| |.|| .    |  |||. |...||... . ..  || 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel..are

LIKLIRAVKGStnKmnefSILVHCLSGAGRTGVLCtAMECIAQ-----IA--ERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYD
. .....|. |  |    |..||| .| ||.  .   .| . |     .   |   .|  . .. ||  | . ..|  . ||   
ilnilkvvrds..k....svvvhCstGiGrsaafv.laelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsil
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 976-1117 1.6e-88 291.7 In-house 251-392 (392) alignment 
Range on Protein: 976-1117
Range on HMM: 251-392/392.0
SVTTLSTSTDGDMTIRKLKITRNSKTSHTVTQYQFHGWPKHGSDQQSGARSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDS
 ...||||.|||.. ..|| .|..|.||||||||||||||||||||||||||.|||||||||||.  |||||||||||||||||.|||||||||||| ||
hlqdlstssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegds

VDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYLHTENYEQ
|||||||| |||||||||||||||||.|| ||||||||.|||
vdifqtvkilradrmqfvqteeeyafvydvireylhtekyeq
0048179 (Phosphotyrosine protein) phosphatases II 992-1104 7.7e-15 50.4 In-house 48-139 (144) alignment 
Range on Protein: 992-1104
Range on HMM: 48-139/144.0
KlkitrnsktshtVTQYQFHGWPKHGSDQQ-SGARSLIKLIRAVKGstnkmNEFSILVHCLSGAGRTGVLCTAMECIaqiaeRDSVDIFQTVKTLRADRM
             ..||.. .|| ||  .  .  ......|...       ..  .||||  | ||||.|..|  ..     .  ........ .|. |.
e............giqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrp

QFVQTEEEYAFIYD
. |.... . |...
gavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 998-1109 1.2e-15 52.9 In-house 40-142 (145) alignment 
Range on Protein: 998-1109
Range on HMM: 40-142/145.0
NSKTSHTVTQYQFHGWPKHGSDQQ-SGARSLIKLIRAVKGStnkmnEFSILVHCLSGAGRTGVLCTAMECIAqiaerDSVDIFQTVKTLRADRMQFVQTE
 .  .....||.. .|| ||  .  .  ......|...  .     .  .||||  | ||||.|. |. ..       .|....... .|. |...|...
lellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnp

EEYAFIYDAIREY
. . |.|....|.
gqlrflyefelel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1000-1112 4.3e-21 69.7 In-house 86-196 (440) alignment 
Range on Protein: 1000-1112
Range on HMM: 86-196/440.0
KTSHTVTQYQFHGWPKHGSDQQSGarSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEY
  |.|. ||...||| .|  . .|   ..|.|. |. | .|  .  .|||| .|||||||. .    . .    | .|||  ....| .| |.||| |.|
iesrtlkqyhyqgwpdkgvpkfag..pvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

AFIYDAIREYLHT
||...|. | | .
afvheavlegllc
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1001-1114 1.2e-53 177.0 In-house 170-280 (515) alignment 
Range on Protein: 1001-1114
Range on HMM: 170-280/515.0
TSHTVTQYQFHGWPKHGSDQQsgARSLIKLIRAVKGSTNKMNeFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYA
 |.||||..|..||..|....  ..||.|||..|| ...... .....||..|.|||||........|.... ..||.|..|. .|..|...|||.|.||
dsrtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqya

FIYDAIREYLHTEN
|||.|..|.|.  |
fiygavledllwrn
PTPc_DSPc_SM00012 1004-1107 2.3e-27 90.6 In-house 1-104 (105) alignment 
Range on Protein: 1004-1107
Range on HMM: 1-104/105.0
TVTQYQFHGWPKHGSDQQSgaRSLIKLIRAVKGSTNKMN-EFSILVHCLSGAGRTGVLCTAMECIAQIAER-DSVDIFQTVKTLRADRMQFVQTEEEYAF
||..|...|||.||  ..|   |...|.|||| ..|| . . ...|||  |.||||.....  .. |. .. ..|||||.|| ||  |.. |||||.| |
tvkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

IYDAIR
.|.|. 
lyrall
subfamily_PTPDC1_pd Subfamily PTPDC1 1023-1104 1.1e-06 23.2 In-house 94-170 (182) alignment 
Range on Protein: 1023-1104
Range on HMM: 94-170/182.0
GARSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTAMECIAQiaerdSVDIFQTVKTLRADRMQFVQTEEEYAFIYD
|..|| ...  ||  .  ..|  . ||| .| |||||| ...   |.     ...  ...|..|. | . .|| |   .. .
gvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvke
0038934 (Phosphotyrosine protein) phosphatases II 1024-1063 4.8e-06 21.8 In-house 96-135 (194) alignment 
Range on Protein: 1024-1063
Range on HMM: 96-135/194.0
ARSLIKLIRAVKGSTNKMNEFSILVHCLSGAGRTGVLCTA
   | . ...|.  .|. ..  ..|||  | ||||.|. |
leillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_CG42327_pd Subfamily CG42327 1037-1109 8.6e-14 45.9 In-house 241-314 (319) alignment 
Range on Protein: 1037-1109
Range on HMM: 241-314/319.0
STNKMNEFSILVHCLSGAGRTGVLCTAMECIAQIAER-DSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREY
| .. .   . |||  |.||||.. ..   | .. |   |||| |.|  .| || . |.| | |.|||  . ||
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1039-1110 9.4e-10 32.7 In-house 258-344 (350) alignment 
Range on Protein: 1039-1110
Range on HMM: 258-344/350.0
NKMNEFSILVHCLSGAGRTGVLCTAMECIA------QIAERD---------SVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
.. .  .||||| .| ||||.|.|    .       .. ..             |...|. ||  |.. ||. . . |||.|.. | 
dnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1039-1110 1.4e-07 25.2 In-house 261-344 (349) alignment 
Range on Protein: 1039-1110
Range on HMM: 261-344/349.0
NKMNEFSILVHCLSGAGRTGVLCTAMECIA--QIAERDSVD----------IFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
.. .  ..|||| .| ||||||.|    ..  .  ...|.           |. .| .||  |.. ||   .. .||.|. .|.
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1043-1107 7.6e-10 33.1 In-house 228-292 (297) alignment 
Range on Protein: 1043-1107
Range on HMM: 228-292/297.0
EFSILVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIR
.  .|||| .| ||.||.  ..  .|..  .   |.   .. ||  | . ||| |.. ..|||. 
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1047-1110 1.7e-13 44.7 In-house 2-65 (69) alignment 
Range on Protein: 1047-1110
Range on HMM: 2-65/69.0
LVHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
.||| ||.|||| . . |  .|.|     ||||  |. .|  |   |  | || ||.||. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1048-1110 1.7e-13 44.7 In-house 2-64 (69) alignment 
Range on Protein: 1048-1110
Range on HMM: 2-64/69.0
VHCLSGAGRTGVLCTAMECIAQIAERDSVDIFQTVKTLRADRMQFVQTEEEYAFIYDAIREYL
||| ||.|||| . . |  .|.|     ||||  |. .|  |   |  |.|| ||.||. | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal