Gene SpurPTP-sf1-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP079_AA protein Get Run
SpurP079_AA_438-713 phosphatase_domain Get Run
SpurP079_AA_725-999 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 194-274 1.1e-06 21.9 Pfam-A 19-80 (85) alignment 
Range on Protein: 194-274
Range on HMM: 19-80/85.0
QWDPSSdTLYGPIVGYKIYVRSDNIIVltkevlpssmvnntdrsVSKRSAENATEMvMYNVSGLEAGSTYSVHIAAIRDGI
.|.|.. .  |||.||.. .|...                    ..|.    .|..  ....||..|..|.. ..|. .. 
sWsppk.dgggpitgYeveyrekggge.................ewkeftvprttt.svtltgLkpgteYefrVqavngag
TMEM154 TMEM154 protein family 330-366 3.5e-06 18.4 Pfam-A 65-103 (146) alignment 
Range on Protein: 330-366
Range on HMM: 65-103/146.0
AILL--ILIIIIVVIIVFKRRRNDSNPSKKGNVEDQYQA
...|  .|.......|..||.|.  ....... ||... 
svvLillllvvvilvikkkrkrrKqeetsedekedlqld
0050432 (Phosphotyrosine protein) phosphatases II 432-714 3.1e-89 294.6 In-house 20-301 (308) alignment 
Range on Protein: 432-714
Range on HMM: 20-301/308.0
FATRQPIPMAQFPAFVNKNRHTALFSQEFHDLPGPDIYPQ-TVARETINFTKNRYKNILPYDSARVKLevidnDPHSDYFNASYIPSF--DNDKAYIASQ
...  .... ..  ...|   . |...||..|.   .... .||.   |..|||||.|||||. ||||     |..||| ||||.. .  ......|| |
lvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatq

GPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEA-DLVEFGNIKLELVSLEACTGGVKRKMGMRK--GDDYRTVTQFHFTEWPDKGVPK
|| . ...|||||||..||..| |.|||.| ...|| ||||. .  . .|.|.....|.| | . . ..|.. ...  ....||||.||.| ||| ||| 
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

HTSSLLQFIKEVKADHgpNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLW
....||.|...|.  .  . .| ..||||||||||..| .| .... .....||||. |  .|..||.|||| ||| |.| |.|| |..
speilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 434-725 4.5e-120 395.2 In-house 6-297 (297) alignment 
Range on Protein: 434-725
Range on HMM: 6-297/297.0
TRQPIPMAQFPAFVNKNRHTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNdkAYIASQGPNNA
 |.|||...|...|.||||| .||.||..||   |.|||||.. .|| |.|||||||||| ||||.....|| |||.|||..... .   .|..| |..|
errpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

SMDDFWRMVWQENVTTIAMVTKLQEGDKiKCRQYWPNQEadLVEFGNIKLELVSLEACTGGVKRKMGMRKGD--DYRTVTQFHFTEWPDKGVPK--HTSS
...|||.||..|.|.||.|.....|.|| ||..||...    ..||.. ..| |.. ..|..||.. ..||.    | | |..|.||||| |..  ..||
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsass

LLQFIKEVKADHGPNTH-PLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFT
||..|.||. |.. |.. ||..||.||||||||...||||| .|||.  ||.|..|. .||.|||.|||.|||.|.| |||| ||  .| | . .|.
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyfe
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 435-752 1.3e-165 545.6 In-house 1-276 (392) alignment 
Range on Protein: 435-752
Range on HMM: 1-276/392.0
RQPIPMAQFPAFVNKNRHTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNAS
|||||.|||||||.||||.|||..||||||||||||||||.. ||  |||||||||||||||||||||. |.|||.||||||||||.|||||||||| ||
rqpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MDDFWRMVWQENVTTIAMVTKLQEGDkikcrqywpnqeadlvefgniklelvsleactggvkrkmgmrKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFI
.|||||||.|||||||||||||.|||                                          ||||.|||.||||||||||.|||||||||.||
lddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfi

KEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLHTS
||||||.|  ||||||||||||||||||||||||| |||.||||||||||||||.||||||||.||||||||||||||||||||| |.|||||||||.||
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

VGGSGRSKMTKEFETLKS
. | .|||..|||..||.
sdGdvrskqlkefrslka
subfamily_PTPRD_pd Subfamily PTPRD 435-790 1.5e-123 408.4 In-house 2-358 (564) alignment 
Range on Protein: 435-790
Range on HMM: 2-358/564.0
RQPIPMAQFPAFVNKNR--HTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNN
..|||.|.....|.| .  . . |..|....  ..  . ..|.. .|  ||||.||..||. ||.|. ...|. ||| |||.| .....|||||.||| .
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQeAdLVEFGNIKLELVSLEACTGGVKRKMGMR--KGDDYRTVTQFHFTEWPDKGVPKHTSSL
 ...|||||||..|..|| |.|||.| .| || .|||..     ..|... .|.. |  .  . |.. ..  | .. |.|.|||||.|||.|||... ||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

LQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQD
|..|..|.| . |...|...||||||||||. | ||.... .|  ..||....|...|..|..||||.|||.||. |.|| |   || . . ....||| 
LdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqk

LHTSVGGSGRSKMTKEFETLKSLCPDpPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILD
|.. . ... ... .||. |..  .. ....  ..  | |. |||. | |.|...||.|.
LaeveedtemtgleleFqrLatakei.eleefavatkpknkkknrfsnilalescrvvls
subfamily_PTPRB_pd Subfamily PTPRB 435-710 1.7e-91 301.3 In-house 4-283 (293) alignment 
Range on Protein: 435-710
Range on HMM: 4-283/293.0
RQPIPMAQFPAFVNKNR--HTALFSQEFHDLPGP-DIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPN
 .|| . .| ..|.|..    . ||.|...|        ...|....| .||||.|||||| .||||. ......||| ||.||| .   . .||.||| 
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

NASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLvEFGNIKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLL
  ..||||||||......| |.|.| |. |.|| .|||..| .   .|.||..||. |  .  | |.. ..|... |.|.|.||| ||| |||..|..||
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktll

QFIKEVKADH--GPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.|...|.  .    ...|...||||||||||. |..| .... ... .||.| .|...|..| ..|||..|| ||. .||.
dfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 435-740 3.2e-89 294.0 In-house 3-307 (315) alignment 
Range on Protein: 435-740
Range on HMM: 3-307/315.0
RQPIPMAQFPAFVNKNRHT--ALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNN
.||||. |. ..| ... .    | |..  .|| ...|  ||... |  |||| ||..|| .||.| ...||||||| ||..|. ..  . |||.|||| 
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQeadLVEFGNIKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQ
||..||||.|..|....| |.|.| ||.| |. .|||..    | .|.| . ..| |  |    | . .  ||. |.| |.|.| ||| ||||.| .|..
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmn

FIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLH
.|. ||  |  .  ....||||||||||  |..|.|.|.|.  ...||.||.|..||.|  |||. ||| ||| |.|| ..  .| |    . .. . | 
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsll

TSVGGSGR
.    .| 
apspdtgs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 435-518 1.4e-13 45.0 In-house 3-86 (440) alignment 
Range on Protein: 435-518
Range on HMM: 3-86/440.0
RQPIPMAQFPAFVNKNRHTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSF
..|| .|.|  .|..|| .  | .|.  ||     |  .|    |  ||||.||| || .|| || .   |.||| ||||| . 
qrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 436-750 4.9e-197 648.1 In-house 1-315 (315) alignment 
Range on Protein: 436-750
Range on HMM: 1-315/315.0
QPIPMAQFPAFVNKNRHTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASM
||||.|||||||||||||||||.||||||.||||.|.||||||||.|||||||||.|||||||||||..|.|||.|||||.|.|.||||||||||..||.
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

DDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIK
|||||||.||.||||.||||.|||||||||||||...||.||||.||.||.||||.|.||.||...||....||||||.|||||||||.|.|||||..||
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklik

EVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLHTSV
|||||.|.....|..||||||||||||||||.||...||||.|||||||.|.|.||||.|||.|.|||||.|||||||||||||||||||||||||||||
evkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsv

GGSGRSKMTKEFETL
.||||||||||||||
dgsgrskmtkefetl
subfamily_PTPRA_pd Subfamily PTPRA 436-747 4.2e-88 290.4 In-house 12-330 (330) alignment 
Range on Protein: 436-747
Range on HMM: 12-330/330.0
QPIPMAQFPAFVNKN--RHTALFSQEFHDLPGPDIYPQ-TVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNN
 |.|. ..   ...     . || .||  ||  .|     .| .  |  |||. |||||| .|| | |..  ..||| |||.|  . . . .||.||| .
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

ASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEadLVEFGNIKLELVSLEACTGGVKRKMGMR------KGDDYRTVTQFHFTEWPDKGVPKH
 ...|||||.|. . .|| |.|.|.| .. || ||||..   || .|||..|.   . .     ||. ..      . .. | |.||||| ||| ||| .
etvedfwrmiweqksativmltelkerkeekcaqywPdeG..lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

TSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTD
.  .|...|.||. .  .. |...||||||||||  | .|.|..  |  |.||||.|| ..|..|| ||||.||| ||| ..||  |. .| . |. .  
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek

HLQDLHTSVGGSGRSKMTKEF
||| |.... |  .  . .||
hlqklynkitgtdkigleeef
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 437-888 9.9e-285 939.4 In-house 1-452 (515) alignment 
Range on Protein: 437-888
Range on HMM: 1-452/515.0
PIPMAQFPAFVNKNRHTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMD
|.|.|||||||||||||.|||.||||||||.|||||||.| |||.||||||||||||.|||||||...|||||||||||||||||||||||||||.||.|
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKE
||||.|.|||||||||||||.||||||| .|||.. .| |.||.||.|||||||||||.|||. . ||||.||||||||||||||||||||||||..|||
dfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklike

VKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLHTSVG
||||||  ||||||||||||||||||||||||| ||| |||||||||||||||||||.||||||||||||||||||||||||| ||||||||||||.|  
vkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgd

GSGRSKMTKEFETLKSLCPDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDQDYINASQMKGVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIV
| |||||||||.|||||||||| |.|||||| ||.||||||||||||||||||||||.||||||||||.||||||||||||||||||||||. .||||||
grgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspdhdyinasqmkgihctfmttqmplpttvsdfwsmvlnnkpstiv

MLNDKSQNDKSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRNSN
|||||||||||||||||||.| |||||||.||||||||||| ||..|||||.
mlndksqndkscaqywpdansvqfgsysvstlstssdgdmtirqlqvtrnsk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 437-732 1.4e-85 282.1 In-house 3-303 (305) alignment 
Range on Protein: 437-732
Range on HMM: 3-303/305.0
PIPMAQFPAFVNKNRHTA--LFSQEFHDLPGPdIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNAS
.| .... |.....| .    . .... |.     .  | ... | .|||.|.| ..|  |..|   .....||| ||||. .... |.||..||| .  
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

MDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEACTGGVKRKMGMRK---GDDYRTVTQFHFTEWPDKGVPKHTSSLL
..||||....| |.|| |.|||.||.| |||||||..... .|||....|| | .. .. ..||. . .    .. |||.|...|.|||.|||. ..|||
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

QFIKEVKADHGPNTH-PLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQD
..||.|. |.  .   ||..||||||||||| |..|  ....|.  .||||. . ..|.||..||||..|| |.. |. | .   .| |..  .. ... 
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

LH
|.
lk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 438-712 1.6e-66 219.2 In-house 2-278 (287) alignment 
Range on Protein: 438-712
Range on HMM: 2-278/287.0
IPMAQFPAFVNKNRHT--ALFSQEFHDLPGPDIYPQ--TVARETINFTKNRYKNILPYDSARVKLEvidnDPHSDYFNASYIPSFDNDKAYIASQGPNNA
||. .|  ||.|....    |.. |  |   .  ..  |..  . |  |||...||..|  || |.    . | || ||..| .. ..||.|....|   
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

SMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEAdlVEFGNIKLELVSLEACTGGVKRKMGMRK---GDDYRTVTQFHFTEWPDKG-VPKHTSS
 . .||......|||.| |.....| |. .| ||||....  | .|. ..||.. |  .| ..||. ...    .| ..|.|...|.|...| |... ..
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

LLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
||.. . .|... .   ....|||..|||... ....  ....|.   .|||. . . |...| .||| ||| ||. .||| |
llvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 438-711 5.1e-66 217.5 In-house 2-282 (290) alignment 
Range on Protein: 438-711
Range on HMM: 2-282/290.0
IPMAQFPAFVNKNR--HTALFSQEFHDLPG-PDIYPQTVARETINFTKNRYKNILPYDSARVKLEVID--NDPHSDYFNASYIPSFDNDKAYIASQGPNN
||. .|  || ...   .  | ..|. |      .  ||.  . | ..||..||..||  |. |  |   .|   .| ||.||  . ..|.||| ||| .
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLveFGNIKLELVSLEACTGGVKRKMGMRKGDD---YRTVTQFHFTEWPDKG-VPKHTS
  . |||...|||.|| | |.|. .| .| ||.||||.....   .|.....|.. |.... ..||. ... .     ..|||...| |...| |.....
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt

SLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
.||.. . .|  . .  .....|||..|||..| ....  ....| .  .|||. . . |...| .|||..|| .|.  ||. 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
0040438 (Phosphotyrosine protein) phosphatases II 440-749 1.5e-88 292.4 In-house 5-313 (317) alignment 
Range on Protein: 440-749
Range on HMM: 5-313/317.0
MAQFPAFVNKNRHtALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFW
. ..  ...|. .  ....||.||.  .... .||.   |  ||||..|||||. |||| ....|..||| ||||.. ..  ...|| ||| . ...|||
lllalldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMVWQENVTTIAMVTKLQEGDKIKCRQYWPNqeADLVEFGNIKLELVSLEACTGGVKRKMGMR--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEV
||||...||.| |.|.| | ...|| ||||.   . ...|... .|.| | . | . |.. .   .... ||||.||.| ||| |||.....||.|...|
rmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

KADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLHTSVGG
..   .. .|...||||||||||..| .. .... .... |||.. |  .|..||..||| ||| |.| |.|| |....||. . ..  .|. |.. . .
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplal

SGRSKMTKEFET
.. . ..||...
ddvklkekelkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 441-747 4.9e-88 290.2 In-house 8-318 (319) alignment 
Range on Protein: 441-747
Range on HMM: 8-318/319.0
AQFPAFVNKNR--HTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDF
...   ... .   . |. .||..| ...    . | . .| .||||.|||.|| .||.|  .|. . ||| |||.| .... ...|| |.| .  ..||
qeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedf

WRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEadLVEFGNIKLELVSLEACTGGVKRKMGMRK-GDDY--RTVTQFHFTEWPDKGVPKHTSSLLQFIK
|||||.|.. .. |.|||.|  |.|...|||...   .|.|.. ..| . |   . ..||. ..|  ..   |.|..|..|||||..||... |||...|
WrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllk

EVK-ADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLHTS
... . ....  |...||||||||||  | .| .... |.  ..|||..| ..| .|. |||..||| ||| |.|| .   .| | | .. | |..|   
rirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaek

VGGSGRSKMTKEF
| ..| ... .||
vadtgetgleref
0039614 (Phosphotyrosine protein) phosphatases II 443-716 3.7e-81 268.1 In-house 21-293 (297) alignment 
Range on Protein: 443-716
Range on HMM: 21-293/297.0
FPAFVNKNRHTALFSQEFHDLPGPDIyPQTVARETINFTKNRYKNILPYDSARVKLEVIDN-DPHSDYFNASYIPSFDN-DKAYIASQGPNNASMDDFWR
.  ...|   . |. .|| .|.   . ....|.   | .|||||.|||||. |||| ..|. |..||| ||||.. .|  ....||.|||.. ...||||
lllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

MVWQENVTTIAMVTKLQEGDKiKCRQYWPNQEAdlvEFGNIKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKAD
|||...||.| |.||| | .. || ||||. .    ..|... .|.. | . | . |.. .....  ||||.|..| ||| ||| ....||.|...|.  
mvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrea

HG--PNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRN
.   |. .| ..||||||||||..| .. .... .... |||.. |  .|..||..||| .|| |.| |.|| |....
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_PTPN9_pd Subfamily PTPN9 443-710 2.4e-72 238.5 In-house 6-288 (297) alignment 
Range on Protein: 443-710
Range on HMM: 6-288/297.0
FPAFVNKNRHTALfSQEFHDLPGPDIY-PQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRM
. |.|.....  | |.|. ..    .    ....   | .||||...| ||..||.|. .|.|..||| ||...  . . ||.|| ||| .  ..|||||
lvayvkekgkrGl.skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrm

VWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEACTGGVKRKMGMR--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKA
||...| .| |.|.. |  ..||.||||..| .  |||..... |. |     ..|.. ..  | .. |.|| | |. ||| |||. ..|||.....|. 
vWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvre

DH-------------GPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
                |.  |...|||||.||||  |..|  ... ... .|||.. |  .|..| ...||.|||.| | ||||
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Ptp69D_pd Subfamily Ptp69D 445-731 1.4e-82 272.2 In-house 12-305 (307) alignment 
Range on Protein: 445-731
Range on HMM: 12-305/307.0
AFVNKNRHT-ALFSQEFHDLPGPDIYPQTV-ARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMV
|.....|.|  .. .|.. |.   |  .|. . .  |  ||||..| ..|. ||||..|  . .||| |||.| .... | .||.|.| .| ..|||||.
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmi

WQENVTTIAMVTKLQEGDKIKCRQYWPNQeaDLVEFGNIKLELVSLEACTGGVKRKMGMRKGD-------DYRTVTQFHFTEWPDKGVPKHTSSLLQFIK
.. .||.| |...|.| .. || .|||..  | |..|.|  .||| | ..  ..|.. . | .       | | |.|.|.|.|.|  ||... .||..|.
aeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

EVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDL
.|.  .  |  |...||||||||.|.....||.... |    ||.|..| ..|..|. .||  ||| |.| |.|.   . .| . | .. |... |
qvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaierl
0047943 (Phosphotyrosine protein) phosphatases II 446-710 2.7e-83 274.9 In-house 4-270 (273) alignment 
Range on Protein: 446-710
Range on HMM: 4-270/273.0
FVNKNRHTALFSQEFHDLPGPD-IYPQTVARETINFTKNRYKNILPYDSARVKLevidNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQ
...|  ...|. .||..|.    ... .||.   |..|||||.|||||. ||||    .|..||| ||||.. ..  ...|| ||| . ...|||||||.
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

ENVTTIAMVTKLQEGDKIKCRQYWPNQEAD-LVEFGNIKLELVSLEACTGGVKRKMGMRK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADH
.||..| |.|.|.| ...|| ||||. . .  ...|... .|.| | . . ..|.. ...   ...||||.||.|.||| ||| ...|||.||..|.  .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

GP--NTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
    . .| ..||||||||||..| .| ..|. .....|||.. |  .|..||.|||| ||| |.| |.||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 446-710 4.8e-80 264.9 In-house 19-302 (307) alignment 
Range on Protein: 446-710
Range on HMM: 19-302/307.0
FVNKNRHTALFSQEFHDLPGPD---IYPQTVARETINFTKNRYKNILPYDSARVKLEVIDND-PHSDYFNASYI--------PSFDNDKAYIASQGPNNA
....  . ... .||..|.      ... ..|.   | .|||||.|||||. |||| ..|.. ..|||.||||.        ...|.....|| ||| . 
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

SMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQeADLVEFGNIKLELVSLEACTGGVKRKMGMR---KGDDYRTVTQFHFTEWPDKGVPKHTSSL
...|||||.|...||.| |.|.| | ...|| ||||.   . ...||.. .|.| | . | . |.. .    . .  ||||.||.|.||| |||.....|
tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

LQFIKEVKA--DHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|.||.||..  .. |. .| ..||||||||||..| .. . .. ... .   ||... |  .|..|| .||..||| |.| |.||
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 447-716 3.6e-86 284.1 In-house 20-294 (298) alignment 
Range on Protein: 447-716
Range on HMM: 20-294/298.0
VNKNRHTALFSQEFHDLPGPDI----YPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMV
|.|. . . ...||. |           ..|||.. |  |||| .|...||.|| || .|.| .||| |||.. .... .|.||.|.| .... ||||||
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WQENVTTIAMVTKLQEGDKIKCRQYWPNQEADlvEFGNIKLELVSLEACTGGVKRKMGMRKG--DDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKAD
..|...|| |.|.|.| ||.|. .|||.....  ..|.|...| | |  .  ..||. . |   .. |.| |.|||.|||||||....|.|.....|.| 
teedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvras

HGPNT-HPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRN
.  .  .|.|..|||||||.|  | ||||....|. ..||||. |  .|.||| .|||.|||.||| |||| |   |
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0051299 (Phosphotyrosine protein) phosphatases II 448-710 7.3e-89 293.3 In-house 15-284 (288) alignment 
Range on Protein: 448-710
Range on HMM: 15-284/288.0
NK--NRHTALFSQEFHDLPGPD-IYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQ
.|   ...... .||..|.     .....|.   |..||||..|||||. |||| |.|....||| |||||. .......|| ||| . ...|||||||.
lkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvwe

ENVTTIAMVTKLQEGDKIKCRQYWPNqeADLVEFGNIKLELVSLEACTGGVKRKMGMR------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVK
.||..| |.|||.| ...|| ||||.   . ...|.|. .|.| | . . ..|.. ..      ... .||||.||.| ||| ||| ....||.|...|.
qnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr

ADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
  . .. .| ..||||||||||..| .| .... .....|||...|  .|..||.|||| ||| |.| |.||
kalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_CG7180_pd Subfamily CG7180 449-713 7.9e-60 197.0 In-house 12-291 (296) alignment 
Range on Protein: 449-713
Range on HMM: 12-291/296.0
KNRHTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVT
.... ... .|..  |  .|     . .. |  |||. ...||| .|| || .| . .||| ||.|. ||  .|.||  ..| . ..|.|||.|..|.. 
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIAMVTKLQEGDKiKCRQYWPNQEadLVEFGNIKLELVSLEACTGGVKRKMGMRKG------------DDYRTVTQFHFTEWPD-KGVPKHTSSLLQFIK
.. ..||  .  | .. .||||.     ..|.| .|.|. .  .  ..|.. . |              . |.|..|..|||.  . ||  |..|.....
avvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

EVK-----ADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
 |.     .|. |.. |.....| |..|.|| ..||  .. ....  ||||..|  .|..|| .|.. |.| .||  .|| .|
rvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 450-709 1.9e-87 287.9 In-house 17-276 (288) alignment 
Range on Protein: 450-709
Range on HMM: 17-276/288.0
NRHTALFSQEFHDLPG-PDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVT
 |  . ||.|.. |.       .|..|.. | .||||.||||||  ||||.  .. . .|| ||||| . ...|.|||.|||. ....|||..|......
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

TIAMVTKLQEGDKIKCRQYWPNQEADlVEFGNIKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPL
||.|.|.| ||.| || .|||...   ...|.....||. .  .  |.||. . |  . ...||.... |||.|||. .  ||.... ||  .  .| |.
tivmltelveggktkCeeYWPdadkp.knyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpi

IIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
|.||||||||||. |..| ..|. ... ..||...|...|..|. .|||..|| ||| ..|
ivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 450-748 3.1e-74 245.0 In-house 19-324 (325) alignment 
Range on Protein: 450-748
Range on HMM: 19-324/325.0
NRHTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMV--WQenv
 .    |..||  ||  |   ..||    |  |||.||....| .|| ||  ..||.|||.||||. .. . . ..|.| |. |...|.||.|  |.   
aqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...

TTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEACTGGVKRKMGMRKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNT
... .|.   ...| .| .|||.. .. ..|| ....|...|  .  |.|.. ... .  . |.| ||..  |.| ||.|. ..|. ... ||| .   |
csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

------HPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLHTSVGGSG
       |...||||||||||| ||. |....      ||.|.|| ..|..|| ||.| .|| .|| |. | ..  || . |  |  .|  |.     . 
antkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltq

RSKMTKEFE
. .. ||||
klniekefe
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 450-710 2.6e-57 188.8 In-house 11-291 (301) alignment 
Range on Protein: 450-710
Range on HMM: 11-291/301.0
NRHTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDN--DPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENV
. |.  |......|   .  . ||  .  | . ||.||| .||  |. |.   |    . .| ||||| .. . |..||.||| .  . ||||..||| .
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLE-----------------ACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSL
..| |||.|.|| | ||.||||| ||.  |||... .||.                   .  | ..||. ...  . ..|.|.. |.||. || .     
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LQFIKEV-KADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|| | .| .. . ..  |...|||..|.|.|| .|..  .. .|.   ||||. .  .|...| .|.| ||| .|| .. .
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
0043336 (Phosphotyrosine protein) phosphatases II 451-710 1.3e-82 272.7 In-house 17-275 (278) alignment 
Range on Protein: 451-710
Range on HMM: 17-275/278.0
RHTALFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTI
   .|...||..|.  .......|.   |..|||||.|||||. ||||.....|..||| ||||.. ..  ...||.|||.. ...|||||||...||||
nlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

AMVTKLQEGDKIKCRQYWPnqeADLVEFGNIKLELVSLEACTGGVKRKMGMR--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPL
 |.|.| | ...|| ||||    . ...|... .|.. | . . . |.. .   . . .||||..|.. ||| ||| ..|.||.|.|.|.    .. .|.
vmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpv

IIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
..||||||||||..| .. ......... ||... |  .|..|| .|||..|| |.| |.||
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 451-722 4.3e-59 194.7 In-house 6-276 (283) alignment 
Range on Protein: 451-722
Range on HMM: 6-276/283.0
RHTALFSQEFHDLPGPDIyPQTVARETINFTKNRYKNILPYDSARVKLEVIDNdphsDYFNASYIP---SFDNDKAYIASQGPNNASMDDFWRMVWQENV
    || . .. |  ||  . ..|    | .|||...|.|.|  ||.|.   .    || ||..||   | ..|| ||..|.| .  . |||.||..|..
nnnklfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdeki

TTIAMVTKLQEGDKIKCRQYWPNQEAdlVEFGNIKLELVSLEACTGGVKRKMGMRKG---DDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPN
|.| |.|||||. .||| ||||.. .  ...|.  . |    .    ..... .|.     .   .. . . .| . |      ||..| | .      .
taivmltklqedlrikCsqyWPkrGs..edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtesk

THPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVI
  |...|||.|.|||.| |.. . |..|.   .||||. |...|..|. .|||..|| ... .|||. |  .| |  .
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaav
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 453-750 1.3e-91 302.0 In-house 19-318 (318) alignment 
Range on Protein: 453-750
Range on HMM: 19-318/318.0
TALFSQEFHDL-PGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIA
. |.|.|.. | . ..   .. . | .| .|||| |||.||..||||. ..... ||| ||.||. . ..|||||.|.|    ..|||||||. | ..| 
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MVTKLQEGDKIKCRQYWPNQEAdlVEFGNIKLELVSLEACTGGVKRKMGMRK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADH-GPNTHPL
|.|...|  |.|. .|||....   ..|... || .   ..  | |.. ...   .. |.| |.|.|.|||.|||....|||.....|.. .  ....|.
mltqeeergkakvhryWPskgs..rsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

IIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLHTSVGGSGRSKMTKEFE
..||||||||||| | .|......|   .||||..|...|..|. ||||..|| ||| ..|| |   .| .   ........|. .   ||...|  ||.
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefq

TL
 |
rl
0036941 (Phosphotyrosine protein) phosphatases II 453-720 1.5e-83 275.8 In-house 12-285 (297) alignment 
Range on Protein: 453-720
Range on HMM: 12-285/297.0
TALFSQEFHDL-PGPDIYPQTVARETINFTKNRYKNILPYDSARVKLevidNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIA
.||...||..| |   ... .||.   | .|||||.|||||. ||||    .|..|||.||||.. .| ....|| ||| . ...|||||||..|||.| 
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEA--CTGGVKRKMGMRK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKA--DHGPNT
|.|.| | ...|| ||||. | . ...|.....|.| |   ... . |.. . .  ... ||||.||.| ||| ||| ...|||.||..|.   .. |. 
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

HPLIIHCSAGVGRTGVVISIDSVVDHAK---RTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLIL
.| ..||||||||.|..| .| ...  .   ... ||....|  .|..|| .||| ||| |.| |.|| |....| . 
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 454-712 1.4e-82 272.0 In-house 15-276 (281) alignment 
Range on Protein: 454-712
Range on HMM: 15-276/281.0
ALFSQEFHDLPGPDIY-PQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAM
| | .|...|   ..  . | ...  | .||||.||  || .|||..  ... ..|| ||...|.....|.|||.|||  ||...||.|||...|..|.|
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivm

VTKLQEGDKIKCRQYWPNQEAdLVEFGNIKLELVSLEACTGGVKRKMGM-RKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNT-HPLII
||.  |..|.|| .|||....  ...|..... .. |. .  ..||. . |.. . |.|.|...| |||.|||. |. ||.| |||.  . ..| .||.|
vtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSAGVGRTGVVISIDSVVDHAKRT-RMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
||||||||||. |..| .|...... ...|| . |...|..| .||||  ||.|.| |||. |
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN6_pd Subfamily PTPN6 454-709 1.3e-72 239.4 In-house 26-294 (306) alignment 
Range on Protein: 454-709
Range on HMM: 26-294/306.0
ALFSQEFHDLP---GPDIYPQTVARETINFTKNRYKNILPYDSARVKLEvIDNDPHSDYFNASYIP--SFDNDKAYIASQGPNNASMDDFWRMVWQENVT
| |..||..|      . . .. .. . | .|||||||||.| .||.|.  .. | ||| ||.||   . ..||.|||.||  .. . |||||||||| .
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

TIAMVTKLQEGDKIKCRQYWPNQEADLVeFGNIKLELVSLEACTGGVKRKMGMR---KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGP--
 | |.||  |  | || .|||..|..   .|.|... || .. .  . |.. .    |... |.| |.||..|||.||||... .|.|...|.. .    
vivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

--NTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTR---MVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
  .. |...|||||.|||| .| || ...  ...     .|. ..|  .|. |  .|||..|| |.| |. 
eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 454-725 2.3e-58 192.7 In-house 20-292 (439) alignment 
Range on Protein: 454-725
Range on HMM: 20-292/439.0
ALFSQEFHDLP--GPD-IYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTI
 .|...|. .    ||     ..| .  . ||||||.. ..| .|| |. |   ||| |.|| ||  . .|| |||.|||.. . |||||.|......||
eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

AMVTKLQEGDKikcrqYWPNQEAdlVEFGNIKLEL---VSL-EACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVK-ADHGPNT
 |.|.| |  |     ||| ..   | .|.| .     . | . .  |.|      ...  ||| |||.. |||| || ..| .|.|.. .. |.   ..
vmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeey

HPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFT
 |...|||||||||| .|..|  ... |    ||.   |. .|..|  |||.  || ||| |||||. . .. ... .| 
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefk
subfamily_PTPRG_pd Subfamily PTPRG 455-718 8e-75 247.1 In-house 20-293 (563) alignment 
Range on Protein: 455-718
Range on HMM: 20-293/563.0
LFSQEFHDLP---GPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHS-DYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTI
 ||.||..|     ..  . . .... |  |||| ||..||..||||. . .  .. || ||.||  .   ||.||.||| .  .||||||.|..||..|
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

AMVTKLQEGDKIKCRQYWPNqeADLVEFGNIKLELVSLEACTGGVKRKMGMRK-----G---DDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHG
 |.|.|.|  . || .|||.   . ...|.... |.. |  .   .|.. ...     .   |. ..|.|.|.|.|||.|||.|.   |.|.|  .| . 
vmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaank

PNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTL
 .. |...||||||||||. | .|...   ..  .|.||.|.  || .|...|||.||| |.. |.|| .. ..| 
aeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 455-709 9.9e-68 223.2 In-house 6-265 (274) alignment 
Range on Protein: 455-709
Range on HMM: 6-265/274.0
LFSQEFHDLPGPDiyPQTVARETINFTKNRYKNILPYDSARVKLEVI-DNDPHSDYFNASYIPSFDN-DKAYIASQGPNNASMDDFWRMVWQENVTTIAM
 . .|| .||     .|   . . . ||||||.||| . .|| ||    .|. |.| || ||  .|. .|||.| |||    ..|||||..||.|. | |
dlekeflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

VTKLQEGDKIKCRQYWPNQEAD--LVEFGNIKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGP-NTH--P
.|||.| .. || .|.|..|      ..|..... ..   . .   ||. ...  . |.|. . .|.|||. .|.....||....||. ..   |..  |
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklap

LIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
 ..|||||.||||. |.|.  | . ... .|||.. |.|.|..|  ||||.||| .|. |. 
vvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 455-529 7.7e-11 36.0 In-house 24-95 (95) alignment 
Range on Protein: 455-529
Range on HMM: 24-95/95.0
LFSQEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKLEVidnDPHSDYFNASYIPSFDNDKAYIASQG
 | .||. ..     | ||     |  |||. ||.|||..|| |        ||| || ..  .   ..|||.||
efdnefksismtsgapytvgsseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 456-709 1e-43 144.1 In-house 13-266 (281) alignment 
Range on Protein: 456-709
Range on HMM: 13-266/281.0
FSQEFHDLPG-PDIYPQTVARETINFTKNRYKNILPYDSARVKLEV-IDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMV
| ||| .||| |     ||  . .|  |||| ||   | .||.|.| . |   .||  | || |    . || .|||.. .  |||||.|||| |.| |.
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHgpntHPLIIHCS
 .. | .. || .|.| .    ..| .. ..          |  .. .    . | .|.. . ||||  ||. .  .|. .....|       | .||||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars....tppvihcs

AGVGRTGVVISIDSVVDHAK-RTRMVDVFNFVTNIRQ-KRPYMVQTQEQYAFIYGAVL
|||||.| .....  ..  . .  . |. . |. .|   |   ||| .|| .|.  .|
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
0046845 (Phosphotyrosine protein) phosphatases II 458-715 2.5e-86 284.9 In-house 4-277 (284) alignment 
Range on Protein: 458-715
Range on HMM: 4-277/284.0
QEFHDLPGPDIY---PQTVARETINFTKNRYKNILPYDSARVKLEVIDND-PHSDYFNASYIPSF-----DNDKAYIASQGPNNASMDDFWRMVWQENVT
.||. |.   ..   . .||.   |..|||||.|||||. |||| ..|.| ..|||.||||.. .     .. |..|| ||| . ...|||||||..||.
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

TIAMVTKLQEGDKIKCRQYWPNQeADLVEFGNIKLELVSLEACTGGVKRKMGMRK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHG--P
.| |.|.| | ...|| ||||.   . ...|... .|.| | . . ..|.. ...   .. .||||.||.|.||| ||| ....||.|...|.  .   |
vIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlp

NTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTR---MVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWR
. .| ..||||||||||..| .| . .. ....   .|||.. |  .|..||.|||| ||| |.| |.|| |...
gggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0045098 (Phosphotyrosine protein) phosphatases II 458-714 1.9e-70 232.7 In-house 12-274 (278) alignment 
Range on Protein: 458-714
Range on HMM: 12-274/278.0
QEFHDLPGPDIYPQTVARETINFTKNRYKNILPYDSARVKlevidndphsDYFNASYIPSFdnDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQ
. .. |. ....  |.|    |. |||||.|||||. |||          || |||||...  .|..|| ||| .  ..|||||.|....|.| |.|.|.
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

EGDKIKCRQYWPNqeADLVEFGNIKLELVSLEACTGGVKRKMGMR------KGDDYRTVTQFHFTEWPDKGVPKHT--SSLLQFIKEVKADHG-------
|....|| ||||.   . ...|.....|.| | .   ..|.. ..      ...  |.||..|.. ||| ||| ..  .|.|........ .        
elgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

------PNTHPLIIHCSAGVGRTGVVISIDSVVDHAkrTRMVDVFNFVTNIRQKRPY-MVQTQEQYAFIYGAVLEDLLW
      .. .| ..||||||||||... .. . ..    . ||... |. .|..||. .||..||| |.| ..|| ||.
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_CG42327_pd Subfamily CG42327 458-639 3.1e-24 80.2 In-house 9-192 (319) alignment 
Range on Protein: 458-639
Range on HMM: 9-192/319.0
QEFHDLPgpDIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDND-KAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKL
.||.|||   .  .. .  .    |.|. |..|   .|| |. | .|... |..|||.  .|.    |||.| . . |  ||||.||. .  .|  .|.|
eefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl

QEGDKIKCRQYWPNQEA--DLVEFGNIKLELVSLEACTGGVKRKMGMRK--GDDYRTVTQFHFtEWPDKGVPKHTSSLLQFIKEVKA
.|    .| .|.| .|.  .   .|.|.. |   |.    .   . ...  ..  | .| . . .|.. .|| . ..|.  . ||..
selGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_PTPN12_pd Subfamily PTPN12 467-710 2.2e-81 267.9 In-house 28-275 (290) alignment 
Range on Protein: 467-710
Range on HMM: 28-275/290.0
DIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQ
..|........ | .|||||.||||| .||.|. |.....||| ||..|   .....|||.|||  . .||||||.|. ||. . |. .. | .|.||..
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCer

YWPNQEADLVEFGNIKLELVSLEACT-GGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISI
|||..  . .|||.....| . .|.. . . | . ... .. |.|.|||.|.|||.|||. ..|||..|..|.  .  . .||..||||||||||..|.|
YWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

DSVVDHAKRTRM---VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
| | .  |. ..   .|||. |...|..|. .|||.||| ..| ||.|
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 467-733 9.6e-74 243.5 In-house 49-312 (319) alignment 
Range on Protein: 467-733
Range on HMM: 49-312/319.0
DIYPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTklqegdKIKCRQ
.   || |    |  |||. |||..| ..|||| ..    ||| |||..  . . . |||.||| . ...|||||.|. |..|| ..|      | || |
nladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPNQEADLVEFGNIKLELVSLEACtgGVKRKMGMRK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTH--PLIIHCSAGVGRTGV
|||..     | ...|...|   |    | |.. . .     | | .|||||  |||.|||...| |....| |.  .  . |  ....|||||||||||
ywplkivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGv

VISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLHT
 | .| ..|  |. ..|||.||| ..||.|. .||   || ||| |.||. |. .. . .  |  .|..| .
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 468-588 5.3e-10 33.3 In-house 23-145 (332) alignment 
Range on Protein: 468-588
Range on HMM: 23-145/332.0
IYPQTVARETINFTKNRYKNILPYDSARVKLevIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMD-DFWRMVWQENVTTIAMVTKLQEGDKIKCRQ
 ||.|  .   |.  ||   .  .| .||.|    .| . |..|||..  . .  ||| .| | |   .  ||||| . . . | ..  ..| .| |.  
typntydkflnnmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapy

YWPNQ---EADLVEFGNIKLELVSL
   ..   .. | |||   || . |
disdrgfeksflhefgaksleecel
subfamily_PTPN1_pd Subfamily PTPN1 469-711 1.6e-57 189.4 In-house 22-270 (290) alignment 
Range on Protein: 469-711
Range on HMM: 22-270/290.0
YPQTVARETINFTKNRYKNILPYDSARVKLEVIDNdphsDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYW
.|...|..  | ..|||... ||| .|.|||  ||    || ||| .   . .. || .|||    .| ||.|||...  .. |. |. | ..||| |||
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PNQEA-DLVEFG--NIKLELVSLEACTGGVKRKMGMRK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADH--GPNTHPLIIHCSAGVGRTGV
|..|  . ...   ..|..|.| |     . |.. . .   .. |....||.| ||| |||.  ...|.|. .|.      ..  | .||||||.||.| 
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

VISIDSV---VDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
.. .|..   ... . .  ||. . . ..|. |  ..||..|  | | |.|| 
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 469-625 1.4e-07 24.6 In-house 17-156 (169) alignment 
Range on Protein: 469-625
Range on HMM: 17-156/169.0
YPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNAsyipsfdndkayiasqgpnnasmddfwRMVWQENVTTIAMVtklqeGDKIKCRQYW
| . .|  |.| ||||    |    .||||. . .|  ||| ||                           ||.|. | . | ..     ||     ..|
ynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....gdtddknnfw

PNQEADLVEFGNIKLELV--S-------LEACTGGV----KRKMGMRKGDDYRT--VTQFHFTEWPDKGVPK
|..|   .    |  |    |       ..| | ||    .  | . . ||  |  .. .|.. ||..|||.
pekedyqlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpq
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 469-625 1.8e-07 24.1 In-house 16-155 (169) alignment 
Range on Protein: 469-625
Range on HMM: 16-155/169.0
YPQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNAsyipsfdndkayiasqgpnnasmddfwRMVWQENVTTIAMVtklqeGDKIKCRQYW
| . .|  |.| ||||    |    .||||. . .|  ||| ||                           ||.|. | . | ..     ||     ..|
ynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvl.....Gdtddknnfw

PNQEADLVEFGNIKLEL--VSLEA-------CTGGVKR--KMGMRKGDDYRTVTQ----FHFTEWPDKGVPK
|..|   .    |  |    ||          | ||.   .. . ...  ..||.    .|.. ||..|||.
pekedyqlhpavilGewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpq
DSPc_SM00195 470-710 1.5e-83 275.5 In-house 17-260 (263) alignment 
Range on Protein: 470-710
Range on HMM: 17-260/263.0
PQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
. | |..  | .|||||||||||. ||||. ......||| ||.||   ...|.||| ||| .  ..|||||||.|.|..|.|.|. .| .|.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

NQEADLVEFGNIKLELVSLEACT-GGVKRKMGMRKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISID
... .  .||.|...||. | .    ..|.. ..| .  . |.|||.....|||.|||..|.|.|.....|| ..  ...|...||||||||||....||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
..... ... .||.|. |...|..|| ||||.|||.||| |.||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 470-710 1.5e-83 275.5 In-house 17-260 (263) alignment 
Range on Protein: 470-710
Range on HMM: 17-260/263.0
PQTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
. | |..  | .|||||||||||. ||||. ......||| ||.||   ...|.||| ||| .  ..|||||||.|.|..|.|.|. .| .|.|| .|||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

NQEADLVEFGNIKLELVSLEACT-GGVKRKMGMRKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISID
... .  .||.|...||. | .    ..|.. ..| .  . |.|||.....|||.|||..|.|.|.....|| ..  ...|...||||||||||....||
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtid

SVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
..... ... .||.|. |...|..|| ||||.|||.||| |.||
iilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 470-518 1.3e-06 22.3 In-house 30-77 (244) alignment 
Range on Protein: 470-518
Range on HMM: 30-77/244.0
PQTVARETINFTKNRYKNILPYDSARVKLEVIDNDpHSDYFNASYIPSF
 || |  . | ||||| ||||.| .|| |    ..  ||| ||.|| . 
lqtnavlsanatknryinilpfdetrvilssskke.gsdyinanyiqgs
subfamily_PTPRK_pd Subfamily PTPRK 471-749 1.7e-83 275.1 In-house 35-314 (314) alignment 
Range on Protein: 471-749
Range on HMM: 35-314/314.0
QTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPN
  .|..  | .|||...||.|| .||.| .||.||.||| ||..| |. . .|.|. ||| .  . ||||.|..|| ..| |.|.|.|  ..|| .|||.
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

QEADlveFGNIKLELVSLEACTGGVKRKMGMRK----GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISID
.      .|.||.|||. |. .  |.| . ..|     ...|.| ||.|. ||| .||..  .||.....||. . ..  ....||||| ||||. | ||
dtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaid

SVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLHTSVGGSGRSKMTKEFET
.|.| ..| ..||||| | ..|.... ||.|.||| ||| ..||  |  .| | | .|     .       .  |.. .||.|
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlkeefqt
0040439 (Phosphotyrosine protein) phosphatases II 471-710 1.1e-74 246.5 In-house 3-244 (249) alignment 
Range on Protein: 471-710
Range on HMM: 3-244/249.0
QTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPN
 .||.   |  ||||..|||||. ||||..... ..||| |||||. ..  ...|| ||| . ...|||||.|....|.| |.|.|.| ...|| ||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

qeADLVEFGNIKLELVSLEACTGGVKRKMGMR--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKA--DHGPNTHPLIIHCSAGVGRTGVVISID
   . .|.|... .|.| | . . . |.. .   . .. |||.....| ||| |||.....||.||..|.   .. |. .|...||||||||||..| ..
..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

SVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 .... .... ||... |  .|..||..||..||| |.| |.||
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 471-733 7.2e-73 240.5 In-house 17-276 (284) alignment 
Range on Protein: 471-733
Range on HMM: 17-276/284.0
QTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTklqegdKIKCRQYWPN
|| |    |  |||. .||..| ..|||| ..    ||| |||.|  . . . |||.||| . ...|||||.|. |..|| ..|      | || ||||.
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

QEADLVEFGNIKLELVSLEACtgGVKRKMGMRK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTH--PLIIHCSAGVGRTGVVISI
.     | ...|...|.  .    | |.. . .     | |...||||  |||.|||...| |....| |.  .  . |  ....||||||||||| | .
kivikeerfkvkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

DSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTLILVIHFTDHLQDLHT
| ..|  |. ..|||.||| ..||.|. .||   || ||| |.||. |. .. . .  |  .|..| .
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsn
subfamily_PTPRN_pd Subfamily PTPRN 471-711 4.7e-58 191.2 In-house 48-291 (297) alignment 
Range on Protein: 471-711
Range on HMM: 48-291/297.0
QTVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDN-DKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
..||..  | .|||.|..|||| .||||.   .. .||| ||| |   |    ||||.||| .... |||.|||.. |. | ..|.|.| .  .|..|||
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

NQEADLVEFGNIklELVSLEA-CTGGVKRKMGMR--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISID
.. ... .. ..  .|||    |   . | . ..  . .. ||||||||  ||..|||  . |||.| . |   .   . |...|||.|.||||| | ||
deGsevyhiyev..hlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

SVVDHA-KRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
 |...  |  . .|.   .  .|..|| .|.|..|. |...|| |.
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 472-712 9.6e-81 265.7 In-house 2-242 (250) alignment 
Range on Protein: 472-712
Range on HMM: 2-242/250.0
TVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIkCRQYWPNQ
.||..  |  |||| .|...||.|| ||  . | .||| |||.. ..|. ||.||.||| .|.. ||||||..|...|| |.|.|.| .|  . |||| .
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

EADlvEFGNIKLELVSLEACTGGVKRKMGMR--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGP-NTHPLIIHCSAGVGRTGVVISIDSV
.|.  ..|.....| | |  .  .|||. .   |  | |.| |.||. |||||||... . |...|.|.| .   .. |.|..|||||||.|  | ||.|
kae..kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

VDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
....|. ..||||...  .|..|| .|...||| |.| ..|. |
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPN13_pd Subfamily PTPN13 472-712 2.5e-68 225.3 In-house 30-269 (273) alignment 
Range on Protein: 472-712
Range on HMM: 30-269/273.0
TVARETINFTKNRYKNILPYDSARVKLEviDNDPhsdYFNASYIP--SFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWP
.|...  | .||||.|.|||| .||||.  |. .   | |||.|     ..   |||.|||   ...|||.|||. ... |||||. .|..|.||..|||
evgkkkenkdknryrnvlPydetrvklg..degg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

NQEADLVEFGN-IKLELVSLEACTGGVKRKMGMRK--GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGpNTHPLIIHCSAGVGRTGVVISID
... . .   | ...||. ..   | | |.. ...    . | |....|..||| |||... .||||..||.  .  .. |...|||||.||.|..|.||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

SVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
 |..  .| . .|| . | ..|..|  .|||..|| |.| |.|| |
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
0037934 (Phosphotyrosine protein) phosphatases II 472-710 3.8e-67 221.7 In-house 3-240 (243) alignment 
Range on Protein: 472-710
Range on HMM: 3-240/243.0
TVARETINFTKNRYKNILPYDSARVKLevidnDPhSDYFNASYIPSFDNdkaYIASQGPNNASMDD----FWRMVWQENVTTIAMVTKLQEGDKIKCRQY
..|.   | .||||..|||||  ||||     .. |||.||..|. ...   .||.||| . . .|    ||||.|....|.| |.|.|.| ...|| ||
siallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPnQEAdlvEFGNIKLELVSLEACTGGVKRKMGMRK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKAD--------HGPNTHPLIIHCSAGV
|| .|    ..|... .|.| | . . . |.. ..    .| .|.|...|.. ||| ||| ....||.|..||..         . .. .|...||||||
wp.gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGVVISIDSVVDHAkrtRmVDVFNFVTNIRQKRPY-MVQTQEQYAFIYGAVLE
||||..| .. . ..    . ||... |  .|..||. .|||..|| |.| |.||
gRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN3_pd Subfamily PTPN3 472-710 6.1e-67 220.5 In-house 34-273 (280) alignment 
Range on Protein: 472-710
Range on HMM: 34-273/280.0
TVARETINFTKNRYKNILPYDSARVKLEvidNDPHsDYFNASY----IPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQY
..|| . | .||||..|||||..||||.   . .  || ||.|    ||| .  . |||.||| . .. |||.|||......| |.| | |  ..|| ||
saarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqy

WPNqEADLVEFGNIKLELVSLEACTGGVKRKMGMRKGD--DYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISI
||. . | .|.|...... . .. .  | |.. ... .  . |...|. ...|||.|||......|.|...|.. .  ...|...|||||.|||||.| .
WPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlill

DSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.  .    ... | . . | ..|..|  .|||..|| |.  |.|.
etalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 472-713 1.8e-44 147.0 In-house 34-278 (307) alignment 
Range on Protein: 472-713
Range on HMM: 34-278/307.0
TVARETINFTKNRYKNILPYDSARVKLEVidNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQ
||   . |  ||||...   | .|. ...  .   |||  | |.    . | .|..||| .... .|| |. ||.| .. |. |. |  ||||.|||| .
tveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

EADLVEFGNIKL--ELVSLEACTGGV------KRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKAdhgpNTHPLIIHCSAGVGRTGVVI
| .   ||.      .  | | .           .. .  ... ||.... ...|||.|||.   . . ... |.     .| |...||||||||.| ..
egqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtiv

SIDSVVDHAKR-TRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
.|  | |   .     |. ..| ..|..|.| .||. || ...  .|| .|
aislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
0049772 (Phosphotyrosine protein) phosphatases II 472-710 8.9e-39 129.4 In-house 39-278 (314) alignment 
Range on Protein: 472-710
Range on HMM: 39-278/314.0
TVARETINFTKNRYKNILPYDsARVKLEVIDNDPhSDYFNASYIPSFdndKAYIASQGPNNASMDDF----------WRMV--WQENVTTIAM-------
.||.   | .||||..|||.|  ||.|   ...  |||.||||. .|   ...||.|||..  ..||          ||||  .. || .| |       
lvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VTKLQEGDkikcRQYWPNQEADLVefgniklelvsleactggvkrK-------MgmrkgddYRTVTQFHFTEWPDKGVPkHTSSLL
               ..| ..      ....   ..|                      .                |.. ... . .|| ..|  .. ..
delsrLdaAlgKtpllildgng....neptaadlellk.....................eelydpelf.......erlgikylripvpDgsap.lledfd

QFIKEVKADhgPNTHPLIIHCSAGVGRTG--VVISIdsVVDHAKrtrMvDVFNFVTNIRQKRP-----YMVQTQEQYAFIYGAVLE
.|.. ...   .. .|...||.||.||||  ||. .  .. . .   . ..   .  .|.|||      .....||| ||. |.||
eflefieea..dkggpvlvHCkaGkgRtgtfvvaay..lmkllg...v.sleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_egg_pd Subfamily egg 472-709 8.5e-27 88.6 In-house 33-267 (307) alignment 
Range on Protein: 472-709
Range on HMM: 33-267/307.0
TVARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDkiKCRQYWPNQ
| | .  | .| | | .   ||.|||||.       |.  | ..        .| .| |   ..|||||||.||.|  | |.|  .| .  .|  |||. 
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpka

EADLVEF--GNIKLELVSLEACTGGVKRKMGMRK-GDDyrtVTQFHFTEWP-DKGVPKHTSSLLQFIKEVKAdhgpNTHPLIIHCSAGVGRTGVVISIDS
|.| . .  |....| . ..  .  . |   ..  | |     . .   |  |     .  | |. .. ..      ..| ....  || .......|. 
esdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehwqgdvnnssdvysplrvlrklrn....lskpvvvqdilGvskaatlvaiei

VVDHAKRTRM--VDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
 . .  |  .    | . |  .|..|.. |..  .| |.|  ||
allsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0042113 (Phosphotyrosine protein) phosphatases II 473-710 9.2e-73 239.9 In-house 3-241 (245) alignment 
Range on Protein: 473-710
Range on HMM: 3-241/245.0
VARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNqe
||.   | .||||..|||||. |||| ....|..||| ||||.. ..  . .||.||| . . .|||||.|....||| |.|.. | ...|| ||||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

ADLVEFGNIKLELVSLEACTGGVKRKMGMR--KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHG-PNTHPLIIHCSAGVGRTGVVISIDSVV
 . ...|... .|.| | . . . |.. .   . | .|.|...|.. ||| ||| ....||.|...|.     .. .|...||||||||||..| .. ..
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

DHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
....... |.... |  .|..|| .|||..|| |.| |.||
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN14_pd Subfamily PTPN14 473-710 5.9e-57 187.9 In-house 43-294 (300) alignment 
Range on Protein: 473-710
Range on HMM: 43-294/300.0
VARETINFTKNRYKNILPYDSARVKLEVIDNDpHSDYFNASYIPS--FDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPN
.|.   |  |||.|..|||. .||.|    .. ...| ||| |      ... ||..||| .  . |||.|||...|. |.|.|. .|. | |. .|.|.
taklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

Q--EADLVEFGNIKLE--LVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKA--DHGPN-------THPLIIHCSAGVG
.  ... ||||. |.   ...   ..   . |.      ..|||  . .|.|||.|||.  .. |....||..   .  .         |...|||||||
leskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
||||.|  | ..   .  . .|. . .. .|..| ..|||  || |.| ....
rtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 473-709 6.8e-51 167.7 In-house 32-274 (287) alignment 
Range on Protein: 473-709
Range on HMM: 32-274/287.0
VARETINFTKNRYKNILPYDSARVKLeVIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQE
 | |. .  |||| ..||.| .|| | . . .  ||| || |..|. .|.|.||.|||  |.. ||||.|...........|.  |  . || .|||..|
aaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

ADLVeFGN---IKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEV-----KADHGPNTHPLIIHCSAGVGRTGVVIS
  .   |    . |.   .|   |    ..   .. . | | |... .||||...  . .|..|. .|      |  . .. ||..|...|.||.|....
vPmr.vGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

IDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
.  .|.  . .  ||| . |  .|..|  .||.  |. ..| |. 
tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 474-710 2.2e-72 238.0 In-house 2-238 (239) alignment 
Range on Protein: 474-710
Range on HMM: 2-238/239.0
ARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDN-DKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQE
|.. .| .|||| ||. || .|| || . ||||||| ||||.  .|   |||||.||  ..|  |||||.|||    | |.| | || | ||.||||.  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

AdlvEFGNIKLELVSLEACTGGVKRKMGMRKG--DDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVD
.   .. |... |   |  .  . | . | .    . | | |.||| |||||||......| . ...  |  | ..| .||||||||||| .. ||... 
s...kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.||. . ||.||.|  ||. ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 474-710 2.7e-72 237.8 In-house 3-239 (239) alignment 
Range on Protein: 474-710
Range on HMM: 3-239/239.0
ARETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFDN-DKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQE
|.. .| .|||| ||. || .|| || . ||||||| ||||.  .|   |||||.||  ..|  |||||.|||    | |.| | || | ||.||||.  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

AdlvEFGNIKLELVSLEACTGGVKRKMGMRKG--DDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVD
.   .. |... |   |  .  . | . | .    . | | |.||| |||||||......| . ...  |  | ..| .||||||||||| .. ||... 
s...kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

HAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.||. . ||.||.|  ||. ||.|||| ||| ||. ||||
qakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN23_pd Subfamily PTPN23 474-711 2.9e-62 205.1 In-house 38-279 (288) alignment 
Range on Protein: 474-711
Range on HMM: 38-279/288.0
ARETINFTKNRYKNILPYDSARVKLEvidnDPHSDYFNASYIPSFDND-KAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQE
|   .. .|||...|||||..||||.    . . || |||.. .       .||.|.| . .. |||.||... . .| |... .| .| |. .|||...
aiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk

ADLVEFGNIKLELVSLEACTGGVKRKMG--MRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKA----DHGPNTHPLIIHCSAGVGRTGVVISID
 . |.||.... | | .     |.|..   ... |  ..|.  ..|.||. |||.  ..||||..||..     . .   ||..|||||||||||.  . 
getvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvy

SVVDHA-KRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
..|    |.  ..|. . |  .|..| .|||..||. | | |||| 
aavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 474-635 9.9e-36 118.1 In-house 28-191 (297) alignment 
Range on Protein: 474-635
Range on HMM: 28-191/297.0
ARETINFTKNRYKNILPYDSARVKLEviDNDPHSDYFNASYI--PSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQ
|.    . ||||..|| .|..||||      . .|| || |.  |  ..|  || .||| .|..||||..|....| .|.||.||||. . ||  |||. 
akrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

EADLVEFGNIKLELVSLEACT---GGVkRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIK
. .  . |.. .| .|  .       .  .. .   .. | |.   |  |||.|||     | .|  
vqerlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_eak_pd Subfamily eak 474-718 8.6e-21 68.7 In-house 47-311 (332) alignment 
Range on Protein: 474-718
Range on HMM: 47-311/332.0
ARETINFTKNrYKNILPYDSARVKLEVIDNDPHsDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEA
.. . .  .|   .|.|||   |.|     ..   | ||| .   .  . || .  ...  .  ||.|| ...  .| .. .  | .  |  .|.|..  
tarleavnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

DLVEFGNIKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTS--SLLQFIKEV------------------KADHGPNTHPLIIHCS
. ..|| ...|  .         |.. ..||..   |  ...  | .  .||     .| . .|||                  |  | | ..  || ..
eelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsa

AGVGRTGVVISIDSVVD--HAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNTL
 |  |.|| . || ..    .|.. .  | ...  ...|| . | .. |..||| .||. || ||  
rGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 476-710 2.4e-68 225.1 In-house 17-262 (270) alignment 
Range on Protein: 476-710
Range on HMM: 17-262/270.0
ETINFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSFD-NDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEAD
 . . . |||..|||   .||.|| ...|... |.|| |.. || ..|.|||..|| .... .||||.|.|.||.|.|.|.|.|  . || .|||..  .
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

--LVEFGNIKLELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTS------SLLQFIKEVKADHGPN--THPLIIHCSAGVGRTGVVIS
   .|.|.||   .| |  .| ..... ...  . | .. |....|||.|||...       .||. ...|.. .     ..||..||||||||||..| 
kvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.| .|   ..|. ||| . ....|..|. .||. |||.|.| ||.|
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 476-710 1.1e-39 131.1 In-house 45-285 (305) alignment 
Range on Protein: 476-710
Range on HMM: 45-285/305.0
ETINFTKNRYKNILPYDSARVKLEviDNDPHsDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADL
|. .  |||||..   |  |||||     || .|  | |. .  | | .| .| | . .  ||| | .|..| .| |. .|.|    || .|.. .. | 
eaqeagknrykdvgcldnnrvkle..gpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

VEFGNIKLEL-VSLEAC--------T-GGVKRKMGM--RKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGpnthPLIIHCSAGVGRTGVVI
.|| .    . | .|..        .   |.. . .    | . | ||..|. .|||.|||    ..|..... .. .|    |...|||||.|||| |.
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvv

SIDSVVDHAKRTRMVDVF-NFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 .. ..|     ....     .  ||..|   .||..|| |..  .|.
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 476-709 3.5e-39 129.2 In-house 53-280 (290) alignment 
Range on Protein: 476-709
Range on HMM: 53-280/290.0
ETINFTKNRYKNILPYDSARVKLEvidNDPHSDYFNASYIPSFdnDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADL
.  .|.|||||..   | .|| |.   .  . ||  | |.     .  .| .||. .... |.|||| ||.|..| |. .| |  | || ||.|..| . 
kntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

VEFGNIKLELVSLEACTGGV-KRKMGMRKGDDY--RTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPnthpLIIHCSAGVGRTGVVISIDSVVDHA
. ||.| .     .     . |. . .|. |.     .  ..   |||| |.. | .||. .. ..   ||    ...|||||.||||  ..|.  ..  
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasGp....vvvhcsaGiGrtGtfvaievglqil

KRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVL
   . .|. . |  .|. |   || . ||  .  ..|
ldGkeldlldlvralrnsrlnsvqvdiqylalveill
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 476-713 2.3e-38 126.5 In-house 52-290 (305) alignment 
Range on Protein: 476-713
Range on HMM: 52-290/305.0
ETINFTKNRYKNILPYDSARVKLeviDNDPHSDYFNASYIPS-FDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEAD
  |. |||||...   | . |||   |. . |||  | |.   .  .| .|..||| . ..|.|| || |..|  | |. |  |  |.|| ||||    .
adiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

LVEF-GNIKLELVSLEACT-GGVKRKMGM---R-KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHgpntHPLIIHCSAGVGRTGVVISIDSV
 .|. . | .| ||         . .. .      ||.  .| ....|||||.|||    . |...  ..  .     |...|||||.|||| ...|. .
klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyi

VDHA-KRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
...  .  .   . ..|  .|..| . .|.. || ||.  .|. .|
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 477-715 2.9e-17 57.2 In-house 45-282 (303) alignment 
Range on Protein: 477-715
Range on HMM: 45-282/303.0
TINFTKNRYKNILPYDSARVKLEvidndpHSDYFNASYIpSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPnQEADLV
  |. |||. ...  | ..|||        | |  |||.  .| .|  | .| | . .  |||.|. ...|  . ..    | ||.     .| .. |..
vknmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp.rnqdfl

EFGNIKL---ELVSLEACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKH-TSSLLQFIKEVKAD--HGPNTHPLIIHCSAGVGRTGVVISIDS--V
.| .  .   |.  .|   | | . . . .||    .   |. .|| . .| . .. ... | ....   .  ...| .    .|.||.|    ...  .
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

VDHAKrTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWR
  |..    .|. . . |.|. | . ||   |....|  . | .|  
slhse.qasldlvkclenvrngrlhavqnlsqfsvvytllaehvldn
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 478-715 2e-35 117.2 In-house 42-274 (288) alignment 
Range on Protein: 478-715
Range on HMM: 42-274/288.0
INFTKNRYKNILPYDSARVKLEvidNDPHSdYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVE
 | |..||.|.   | .||||.   .||.  | .|  ..|  ...  | .| | |. .. .|.|. ...|  | |...| |  | |  .|.| .  . . 
anptrdryenlprcditrvkls...ddpdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGNIkLELVSLEActGGVKRKMG------MRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKAdhgpNTHPLIIHCSAGVGRTGVVISIDSVVDH
.| .    |  .    .... .        ..|..   | . |. ||.|.|||.   | |.... .|.     ..|...|.|||||||| .| |  ... 
igrl.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlks....lqkPivvhssaGvGrtgtlililiales

AKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWR
.. .  . . ..... |..|   .||. || ...  |||.|| .
lrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_ptpA1_pd Subfamily ptpA1 478-663 6.3e-34 112.4 In-house 46-247 (418) alignment 
Range on Protein: 478-663
Range on HMM: 46-247/418.0
INFTKNRYKNILPYDSARVKLEVIDNDPHSDYFNASYIPSfDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEAD--L
 | .|||| |||| . .||.|. |..   ||| || ||      | .|..|||   .. |||||||.. .  | |...  |  .||| .|||.|     .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

-------VEFGNIKLELVSL--EACTGGVKRKMGMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKA---DHGP---NTHPLIIHCSAGVGRTG
         ||   .||| .  .     . |.. .    . | .||...  |||. .| ||  . |... .     .  |      |.|.||||||||||
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

VVI
 . 
tfc
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 478-712 1.4e-31 104.5 In-house 34-270 (285) alignment 
Range on Protein: 478-712
Range on HMM: 34-270/285.0
INFTKNRYKNILPYDSARVKLEVIDndphSDYFNASYIPSFDND-KAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLV
 |   ||| ..   . .|| |.  |     ||  ||..    .|  .||..|||   .. |||.|..||... . |.  | ||   ||  |.|..  ..|
anpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

EFGNIKLELV--SLEACTGGVKRKMGMRKGDDYRTV----TQFHFTEWPDKGVPKHTSSLLQFIKEVKAdHGPNTHPLIIHCSAGVGRTGVVISIDSVVD
.||. .. |     || .| .   . . . .|  .      . .   |||.  |. .  .... | ||    |. .|. .|||||||||  .. ||    
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgidyati

HAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
.      ..... | ..|  |   ||.. |. |.|  ..| .
rimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 478-560 7.3e-09 29.6 In-house 36-123 (347) alignment 
Range on Protein: 478-560
Range on HMM: 36-123/347.0
INFTKNRYKNILPYDSARVKL-----EVIDNDPHSDYFNASYIpSFDN-DKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGD
 . .||| |.    |..|| |     .    |.   | |||.|  ||| .| || .| |   .. |||.||   .|| .  . . .. .
kslsknrskdvklidatrvvlspeksknsraddvetyinashi.kfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikde
Y_phosphatase Protein-tyrosine phosphatase 479-710 3.8e-81 267.3 Pfam-A 1-235 (235) alignment 
Range on Protein: 479-710
Range on HMM: 1-235/235.0
NFTKNRYKNILPYDSARVKLeviDNDPH-SDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVE
|..|||||.|||||. ||||   ..... ||| ||.|. .....|..||.||| . ...|||||||||.|..|.|.|.|.| .. || ||||..| . ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGNIKLELV-SLE-ACTGGVKRKMGMRKGDDY---RTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHA
.|.||.||. . . .... . ||. ..| ..    |.|.|.|.|.|||.|||....|||..|..|. .. ....|...||||||||||.....| .....
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.... |||...| ..|..|| |||. |||.|.| |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 479-710 3.8e-81 267.3 In-house 1-235 (235) alignment 
Range on Protein: 479-710
Range on HMM: 1-235/235.0
NFTKNRYKNILPYDSARVKLeviDNDPH-SDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVE
|..|||||.|||||. ||||   ..... ||| ||.|. .....|..||.||| . ...|||||||||.|..|.|.|.|.| .. || ||||..| . ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGNIKLELV-SLE-ACTGGVKRKMGMRKGDDY---RTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHA
.|.||.||. . . .... . ||. ..| ..    |.|.|.|.|.|||.|||....|||..|..|. .. ....|...||||||||||.....| .....
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
.... |||...| ..|..|| |||. |||.|.| |.||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 479-710 5.9e-67 220.4 In-house 3-237 (237) alignment 
Range on Protein: 479-710
Range on HMM: 3-237/237.0
NFTKNRYKNILPYDSARVKLEVIDNDphSDYFNASYIPSFDN-DKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADlVE
|  |||| ||  || .|| |.   ..  ||| ||.|. .||   | |||.||| ..| ||||.|||||. . | |.| | ||...|| .|||. .     
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp.aa

FGNIKLELVSLEACTGGVKRKMGMRK---GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEV--KADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHA
.| . . |   |. .    | . . |     . | . |..|| |||.|||..|..||.| |..  .. | ... | ||||||||||||... ||... .|
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
|  ..||..|.| .| . |||..||..|| ||. ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0041856 (Phosphotyrosine protein) phosphatases II 479-717 2.8e-47 156.0 In-house 1-176 (182) alignment 
Range on Protein: 479-717
Range on HMM: 1-176/182.0
NFTKNRYKNILPYDSARvklevidndpHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTklqegdkikCRQYWPNQEadlvef
|..||||..|||||  |          ..|| ||... .   .. .|| ||| . .. ||.||......||| ..|         ...|||. .      
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gniklelvsleactggvkrkmgmrkgddYRTVTQFHFTEWPDKGVPKhTSSLLQFIKEVKAdhgpNTHPLIIHCSAGVGRTGVVISIDSVVDHakrtrMV
                            .|...|.... ||| |||  ...||.||.||..    . .| ..||||||||||... .. .  .      |
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLLWRNT
.... |  .|..|| ||.| .|| |.. |.|| ||...|
sleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 479-574 8.1e-23 75.7 In-house 47-156 (350) alignment 
Range on Protein: 479-574
Range on HMM: 47-156/350.0
NFTKNRYKNILPYDSARVKLE----VIDN----DPHSDYFNASYIP------SFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKC
 |.||||||||||. .||||.      |        .|| ||.|.       . . |  ||| |.|    .|||.... . .|. | ..|...| .  ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

RQYWPNQEAD
 .||.. . |
yrYWqegsyd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 479-708 1.9e-21 70.7 In-house 51-281 (302) alignment 
Range on Protein: 479-708
Range on HMM: 51-281/302.0
NFTKNRYKNILPYDSARVKLEVIdndpHSDYFNASYI--PSFDndKAYIASQGPNNASM---DDFWRMVWQENVTTIAMVTKLQEGDKiKCRQYWPNQEA
|  ||. ...  .|| .||||        .| ||| .  |..   .  | .| |.  |    ..|||||.||..... .. . .| .|    ...|..  
nlkknqsedvpildsnlvkleae....pdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

DLVEFGNIKLELVSLEACTGGVKRKMG--MRKGDD-YRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVD
| .|.|.. .     |   . ..| .   . .|      ..  ..| |..| ||.. ..| . ...| | . . .....|    |.|| |....   .|.
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

HAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAV
. ..   . . . |..||..|| .|.. .||...| |.
klqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 479-571 1.9e-19 64.3 In-house 52-143 (310) alignment 
Range on Protein: 479-571
Range on HMM: 52-143/310.0
NFTKNRYKNILPYDSARVKLEvIDNDPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQ
.. |||| ...  |..||||. ||.  . ||  | |. .    ...| |||| . .. |||||..||   .| .. |  |  . ||  |||  
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 479-574 6.7e-15 49.2 In-house 48-159 (349) alignment 
Range on Protein: 479-574
Range on HMM: 48-159/349.0
NFTKNRYKNILPYDSARVKLEVIDNDP--------------HSDYFNASYI--PSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKI
 |.|||||.||||. .||||.   . .                || || |.  . .. .| ||| | |  ...|||....  ..|  .  ... .| .  
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KCRQYWPNQEAD
|| .|| . . .
kcdiywqelsys
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 480-707 1.4e-35 117.7 In-house 34-254 (267) alignment 
Range on Protein: 480-707
Range on HMM: 34-254/267.0
FTKNRYKNILPYDSARVKLEVIDNDphsdYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDkIkcRQYWPNQEADLVEFG
  .||. . |||| .|| |   ...    | ||||. ..   .|.|. |.| . .. ||. .. ...|..| ..||  ... |  |..|| . ..  .. 
qernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn.i..rlfwPPkmgqakkyq

NIKLELvSLEACTGG---VKRKMGMrKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIkEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTR
.. .|  |||        .  .. . | .  . || ... .|  .   |     |  |   | .     .||...||.||||.|  . ||| .. ||.  
dltveh.slekeendyqiitlelkf.knesahnvtlyyykkwnintnnkpylkplfgi.laknqlengnrPlvvacsdGvGrsGtflvidsqlerakteg

MVDVFNFVTNIRQKRPYMVQTQEQYAFIYGA
..|.|.|. .||..|. .|.|.|.| .|.  
vsdifdflrkirsqriglvdtkeryiyihel
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 481-704 1.6e-31 104.2 In-house 52-273 (301) alignment 
Range on Protein: 481-704
Range on HMM: 52-273/301.0
TKNRYKNIlPYDSaRVKLEVIDNDPHSdYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGN
 |.||... | .     .|||..        | .||.  . . .||.||| .....||| |. | .| .|.|...  |  . ||..| | . .. .. | 
dkhryptv.PckP.stavevivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

IKLELVSLEACTGG--VKRKMGMRKGD---DYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHgpntHPLIIHCSAGVGRTGVVISIDSVVDHAKRT
 |..... |       .||.. ..      . |||| . ..||.|.||||    | .... ||  .    .|...|||||.||.   |. . .  . .  
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylarevead

RMVDVFNFVTNIRQKRPYMVQTQEQYAFI
. ... . . ..|..|   |||..|  ..
ptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 482-713 2.8e-24 80.4 In-house 46-277 (312) alignment 
Range on Protein: 482-713
Range on HMM: 46-277/312.0
KNRYKNILPYDSARVKLEVIDNdphsDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWpnqeADLVEFGNI
 ||| ||  .|  |  |   .|     |  | ..    . . ....||| . .   ||...     |.| ... . |    || .|     .|.| | ..
lnrypniqcwdrgrftlagden....fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi....sdivgfvdl

KLELVSLEACT-----GGVKRKMGMR-------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHgpntHPLIIHCSAGVGRTGVVISIDSVV
.   |  | ||     |  | |.  |          .   . .. .. |||.|.|    . |...  || |.    .|.| |||||||||| .. |.|..
edhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlaliesmi

DHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
   .  |  .| .    .|. |   |..  || .   .||| | 
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 483-728 1.2e-25 85.3 In-house 23-266 (290) alignment 
Range on Protein: 483-728
Range on HMM: 23-266/290.0
NRYKNILpYDSARVKLEVIDNDPHSDYFNASYIpSFDNDKAYIASQGPNNAS-------MDDFWRMVWQENVTTIAMVTKLQEGDKI----KCRQYWPNQ
.|... |    .|| |..  .   .||. |... .. |. . |..| | ..        . .|| |. ||.|. . |. . .| ..      | .| |..
qRlevpL.veatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

EADLVEFGNIKLELVSLEACTGGVKRKMGMRKGDDY-RTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKAdhgpNTHPLIIHCSAGVGRTGVVISIDSVVD
. . . |......  | |.  .  .|.. .. .|.   |||   . .| .  |...| .||. |. |||    .. | |.||  |. |  .. .|.    
vgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAalaaiilgyQ

HAK-RTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLedllwrntlILVIHFTDHL
     .  | . . . ..|..|  ........||.  ...         .|.|...|. 
kiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........llaievldqf
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 489-573 6.4e-06 20.5 In-house 3-74 (130) alignment 
Range on Protein: 489-573
Range on HMM: 3-74/130.0
LPYDSARVKlevidndpHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDkikcrQYWPNQEA
|... .|..          .| |||..   .. . |. .| |  ..  |||.|. .  |  . ..  ..| |     .|||. | 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdseP
0044763 (Phosphotyrosine protein) phosphatases II 490-707 1.4e-33 111.4 In-house 1-166 (178) alignment 
Range on Protein: 490-707
Range on HMM: 1-166/178.0
PYDSARVKLEVIDNDPHSDYFNASYIPSFdndkAYIASQGPnnasmDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEAdlvefgniklelvsle
|.|  ||.|. . . . |||.|||.|  .     |..|..|      |..........|.| ..|. .|. ..|| .||| ..                 
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

actggvkrkmgmrkgddyrtvTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHakrtRMvDVFNFVTNIRQ
                      |.... .|| |||  .. .|.|.. ... . .. .| ..||||||||.|... .. .  .    .. .... .  .|.
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvre

KRPyMVQTQEQYAFIYGA
.|| .|....|. ..|  
rRp.ivpnpgqlrqLyef
0046846 (Phosphotyrosine protein) phosphatases II 500-708 9.7e-38 125.0 In-house 5-169 (176) alignment 
Range on Protein: 500-708
Range on HMM: 5-169/176.0
VIDNDPHSDYFNASYIPSFdndkAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNqeadLVEFGNiklelvsleactggvkrkm
..  |...|| ||..| .     ..|| ||| . .. ||..|......|.. ..|...| ...|| .|||     | ..|                    
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi...................

gmrkgddyrtvtQFHFTEWPDKGVPKHtSSLLQFIKEVKADHGPNtHPLIIHCSAGVGRTGVVISIDsvvdHAKRTRMVDVFNFVTNIRQKRP-YMVQTQ
            |.... ||| ||| . . ||.......     . .| ..|||||.||||... ..      .. . ..|.. .  .|..|| ..|||.
............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

EQYAFIYGAV
||| |.| ..
eQyrflyefe
0043147 (Phosphotyrosine protein) phosphatases II 504-705 2.9e-39 129.9 In-house 2-154 (172) alignment 
Range on Protein: 504-705
Range on HMM: 2-154/172.0
DPHSDYFNASYIPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLqegdkikcrqywpnqeadlvefgniklelvsleactggvkrkmGMRK
|..||| ||||..     . .|| ||| .  ..|||||......|.| ..|.|                                              .
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydp

GDDYRTVTQFHFTEWPDKGVPkHTSSLLQFIKEVKA-DHGPNTHPLIIHCSAGVGRTGVVISIDSVVdhakrtRMVDVFNFVTNIRQKRPYMVQTQEQYA
 . .|.. |.... ||| ||| ... ||.|.. ..   .  . .| ..||||||||||... .. .       . ..... |  .|.|||..||...|| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FIY
|.|
fly
0051429 (Phosphotyrosine protein) phosphatases II 505-711 3.1e-47 156.8 In-house 2-224 (272) alignment 
Range on Protein: 505-711
Range on HMM: 2-224/272.0
PHSDYFNASYIPSFDN---DKAYIASQGPNNASMDDFWRMvWQENVTTIAMVTKLQEGDKIKCRQYWP----------NQEADLVEFGNIKLELVSLEAC
| |.|.||.... . .   ......|.|| ... .||||. ......|| ..... | .. || .|||          . .|  ...|.. . |.| | .
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

TGGVKRKMGMR---KGDDYRTVTQFHFTEWPDKGVPKHTssLLQFIKEVKAdhgpnTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVD--------V
.  . |.. ..   . ...|.|...|.| ||| |||...  ||...... .      .|...|||||..|||.|. .. ..    .. .||        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FNFVTNIRQKRPYMVQTQEQYAFIYGAVLED
...|  .|..||..|||.|||.|.| |.|| 
eeaveelraqrpgavqteeqylflyeallel
0051082 (Phosphotyrosine protein) phosphatases II 505-708 9.4e-36 118.0 In-house 1-149 (151) alignment 
Range on Protein: 505-708
Range on HMM: 1-149/151.0
PHSDYFNASYIPSFdndkaYIASQGPnnasMDDFWRMVWQENVTTIAMVTKLQEGDkiKCRQYWPNQEadlvefgniklelvsleactggvkrkmgmrkg
|.|||.|.||. ..     ...|.||    ..||..........|| ......| .  .| .|.|...                                
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

ddyRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKAdhgPNTHPLIIHCSAGVGRTGVVISIDSVVDHakrtrmVDVFNFVTNIRQKRPYMVQTQEQYAFI
   ..|...... ||| |.| .. ..|.|.... .   .. .|...|||||.||||... .. .  .      |...  .  .|.|||..||. .|. |.
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YGAV
. |.
lfal
0036282 (Phosphotyrosine protein) phosphatases II 507-705 4.7e-45 148.7 In-house 2-163 (174) alignment 
Range on Protein: 507-705
Range on HMM: 2-163/174.0
SDYFNASYIPSFDNDKAYIASQGPNNasmddFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNqeadlvefgniklelvsleactggvkrkmgmRKGDD
|||.|||..  .   . .||.||| .     ||.|......||. |.....| .. || .|||                                .. | 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

YRTVTQFHFTEWPDKGVPKHTSsLLQFIKEVKADHGP-NTHPLIIHCSAGVGRTGVVISIDSVVDHAKrTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
.|.. |.... ||| |||  .  ||.|.|.|.  .   . .|...||||||||||... .. .  . . ...||....|  .|..||.||||..|| |.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 513-710 3e-19 64.1 In-house 24-219 (255) alignment 
Range on Protein: 513-710
Range on HMM: 24-219/255.0
SYIPSFDNDKAYIASQgpnnaSMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSleACTGGVKRKMGM--R--KGDDYR
 . |. |...  . |      ..| |.... | . ....|.. ..| .. || .|.| .  .   . ....      . .  | | . .     .    .
hvkPekdkkrknlysl.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkth

TVTQFHFTEWPDKGVPKHTSSLLQFIKEVKadhgpNTHPLIIHCSAGVGRTGVVISIDSVVD------HAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYA
||. .... |..|  |. .  .|. .| |.     .......|||.|.||.   . ...|        .   |  .|  ......|.||.  ..|  | |
tvkhysykGWieknaPelareilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqla

FIYGAVLE
|    ||.
fsilmvld
0049260 (Phosphotyrosine protein) phosphatases II 515-705 1.3e-38 127.4 In-house 2-143 (152) alignment 
Range on Protein: 515-705
Range on HMM: 2-143/152.0
IPSFDNDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWpnqeadlvefgniklelvsleactggvkrkmgmrkgddyrtvtQFH
|. . . ...|| ||| . ...|||||... ..||| |.|.|.| .|.|| ||.                                           |..
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVdhakrtRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
.. ||| |||...  ||.... ..     . .| ..||||||||||... .. .       . |.....|  .|.|||..|....|. |.|
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_hpo-7_pd Subfamily hpo-7 516-710 9.2e-16 52.5 In-house 30-225 (263) alignment 
Range on Protein: 516-710
Range on HMM: 30-225/263.0
PSFDNDKAYIASQgpNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEActGGVKRKMGMRK----GDDYRTVT
|. |...  . |       .| |.... | . ....|..  .| .. || .|.| .  .   . |...           ...   . .        .||.
Pekdkkrknlysl..lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvk

QFHFTEWPDKGVPKHTSSLLQFIKEVKadhgpNTHPLIIHCSAGVGRTGVVISIDSVVD------HAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
.. .. |..|  |. . . |. .| ..     | ..|..|||.|.||.     ...|        .   |  .|  ......|..|.  ..|  | ||  
hysykgWiekndpelareilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi

GAVLE
  ||.
lmvLd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 520-580 2.7e-07 24.3 In-house 234-290 (440) alignment 
Range on Protein: 520-580
Range on HMM: 234-290/440.0
NDKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQegDKiKCRQYWPNQEaDLVEFGN
. .|.||.| | .... ||||.| . ...|| |. .|.  ||  |  ||| .    | || 
kknafiatqmpldstvldfwrlvhdyristiimlnqln..dk.tcsiywpvnt.rsvtfgp
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 521-705 4.1e-22 73.3 In-house 4-197 (199) alignment 
Range on Protein: 521-705
Range on HMM: 4-197/199.0
DKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEACTGG----VKRKMGMRKGDDYRTVTQFHFT
.. |||.| |   .| |||.|||.     | ||   |   .     |||  |.   ..|.. .   .. .        .            | .... ||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWPDKGVPKHTsSLLQFI---KEVKADH-GPNTHPLIIHCSAGVGRTGVVISIDSVV-DH-AKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 | .|  |. .  .. |.   .||   .   .  |.|.||| | | ||| ...|  |  |   .| .||.|.    .|| |  .. . ..| |||
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 521-705 7.1e-22 72.5 In-house 3-196 (198) alignment 
Range on Protein: 521-705
Range on HMM: 3-196/198.0
DKAYIASQGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEACTGG----VKRKMGMRKGDDYRTVTQFHFT
.. |||.| |   .. |||.|||.     | ||   |   .     |||  |.   ..|.. .   .. .        .            | .... ||
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWPDKGVPKHTsSLLQFI---KEVKADH-GPNTHPLIIHCSAGVGRTGVVISIDSVV-DH-AKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 | .|  |. .  .. |.   .||   .   .  |.|.||| | | ||| ...|  |  |   .| .||.|.    .|| |  .. . ..| |||
swkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 523-710 1.6e-07 24.2 In-house 116-307 (346) alignment 
Range on Protein: 523-710
Range on HMM: 116-307/346.0
AYIASQG---PNNASMDDFWRMVWQENVTtiaMVTKLQEGDKIKCRQ-YWPNQEADLVEFGNiKLELVSLEACTGGVKRKMG---MRKGDDYRTVTQF-H
  | .|     |.. ..||| |..||..    .|  .   ||.|       |.|    ..   |. .    |   |  ..     . .|.    . |  |
klivaqlpqmenesfvedfwymiyqeqih...lvylmvpddklkntttslfndenggyqytg.kmfinnrradvsgdpkeytievlpegnsdsvicqvhh

FTEWPDKGVPKHTSSLLQFIKEVKADHGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLE
 . |     | .|  ....|.. ....  ..  . .    | ||.   |     ..        .... . ||.|.||  |..  ||| ||  |..
hapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 528-713 5.5e-21 69.3 In-house 97-289 (302) alignment 
Range on Protein: 528-713
Range on HMM: 97-289/302.0
QGPNNASMDDFWRMVWQENVTTIAMVTKLQEGDKIKCRQYWPNQEADLVEFGNIKLELVSLEACTGGVKRK-----------MGMRKGDDYRTVTQFHFT
  | . ... .| .. | ||. .. .... |... || .|. ..  . ..||.  .. ||..        |              .| .  .||  ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

EWPDKGVPKHTSSLLQFIKEVKAdhgpNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDLL
 |||.| ||.. . |. .|  ..      . ...|||||||||| ...|   ..  .. .. |. . |. .|| |   ||...|  ..   |   |.
awpdhGapkeaytaldilkfces....ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglm
0048076 (Phosphotyrosine protein) phosphatases II 600-708 7.9e-23 76.2 In-house 37-139 (145) alignment 
Range on Protein: 600-708
Range on HMM: 37-139/145.0
GMRKGDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNtHPLIIHCSAGVGRTGVVISIDSVVDhakrTRmVDVFNFVTNIRQKRPYMVQTQE
 . . . .|...|.... ||| |||  .. ||.|.. ... .  . .| ..||||||||||... .. .       . |.... .  .|..||..|....
tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpg

QYAFIYGAV
|. |.| ..
qlrflyefe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 604-749 3.6e-36 119.4 In-house 85-231 (440) alignment 
Range on Protein: 604-749
Range on HMM: 85-231/440.0
GDDYRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKAD-HGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYA
| . ||. |.|.  |||||||| .. .|..|..|.   .     ||..|||||.|||||.|..||.. .|||.  .|.|.|. ..|..|| |||| ||||
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

FIYGAVLEDLLWRNTLILVIHFTDHLQDLHTSVGGSGRSKMTKEFET
|.. |||| ||  .||||    |.......     . .| . .||| 
fvheavlegllcgdtliledditerveqiqwpnphtdksplqqefeg
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 606-709 8.4e-15 49.3 In-house 214-341 (350) alignment 
Range on Protein: 606-709
Range on HMM: 214-341/350.0
DYRtVTQFHFTEWPDKGVPKHTSSLLQFIK-------E-VKADH--GPNTHPLIIHCSAGVGRTGVVISIDSVVD-------HAKRTRMV-------D-V
 |  | |...  |.| ..  .  |.|| ..       . .   |    .. |...||||||||||.....||..          |. | .       | .
Pyv.vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

FNFVTNIRQKRPYMVQTQEQYAFIYGAVL
.  | ..|..|  |||. .|. ||| |.|
siivnelrkqrismvqnldqfifiYeall
0048179 (Phosphotyrosine protein) phosphatases II 607-705 5.7e-22 73.4 In-house 46-138 (144) alignment 
Range on Protein: 607-705
Range on HMM: 46-138/144.0
YRTVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPNtHPLIIHCSAGVGRTGVVISIDSVVdhakRTRmVDVFNFVTNIRQKRPYMVQTQEQYAFIY
 |...|.... ||| ||| ... ||.|.. ... . .. .| ..||||||||||... .. ..    . . ..... .  .|..||..|....|. |..
eregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl
PTPc_DSPc_SM00012 609-710 8.7e-34 111.2 In-house 1-105 (105) alignment 
Range on Protein: 609-710
Range on HMM: 1-105/105.0
TVTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPN--THPLIIHCSAGVGRTGVVISIDSVVDHAKRT-RMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
||...|.|.|||.|||....|.|.....||  .  .  ..|...||||||||||... .| .... ... . ||.|..|  .|..|| ||||.||| |.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

GAVLE
 |.||
ralle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 610-705 1.1e-12 42.2 In-house 192-283 (310) alignment 
Range on Protein: 610-705
Range on HMM: 192-283/310.0
VTQFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPnthpLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIY
|.  .. .|||.|||      .      .  |||     ..|||||..|..||....  .|...|   ||. . .|.....|   .||. || .| 
vslikwpnwpdrgvpdekchtvpqrllaqvrhgp....cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 610-710 3.2e-09 30.6 In-house 220-342 (349) alignment 
Range on Protein: 610-710
Range on HMM: 220-342/349.0
VTQFHFTEWPDKGVPKHTSSLLQFIKeVKAD-----------HGPNTHPLIIHCSAGVGRTGVVISIDSVVD-------HAK----RTRMVDVFNFVTNI
. |. . .|.| ..     |.|| .. || |           .  .. .|..||||| |||||.. .|....       .      .. . |.  .. |.
llqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

-RQKRPYMVQTQEQYAFIYGAVLE
 |..|  |||   |. .|| |.|.
lrkqrismvqnlaqfiaiyealLk
subfamily_PTPDC1_pd Subfamily PTPDC1 612-703 1.9e-08 29.0 In-house 84-167 (182) alignment 
Range on Protein: 612-703
Range on HMM: 84-167/182.0
QFHFTEWPDKGVPKHTsSLLQFIKEVKADHgpNTHPLIIHCSAGVGRTGVVISIDSVvdHAKRtrmVDVFNFVTNIRQKRPYMVQTQEQYAF
 ..   |.| ||.  . ..|. .| |.     .   . .|| || |||||.|.   |  .|||   ..  . .. .|.|||  .||.||  .
yvynfgwkDygvasle.riLdivkvvafal..qegkvavhChaGlGrtGvliacylv..yakr...ltaekaiklvrskrpksiqtreqvel
0038934 (Phosphotyrosine protein) phosphatases II 612-704 3.5e-07 25.6 In-house 81-169 (194) alignment 
Range on Protein: 612-704
Range on HMM: 81-169/194.0
QFHFTEWPDKGVPKHTSSLLQFIKEVKADHGPN-THPLIIHCSAGVGRTGVVISIDSVVdhakrTRMVDVFNFVTNIRQKRPYMVQTQEQYAFI
...   .||.|..  .. ||.|.. |.  .  .  .   .|| ||.||||...    .      ..  ..   .  .|.||| ....|...  .
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiy.....rlgmsaeeAialfrekRpgaipnqdyleal
PTEN_1 617-663 6.7e-06 21.0 In-house 101-148 (196) alignment 
Range on Protein: 617-663
Range on HMM: 101-148/196.0
EWPDKGVPKhTSSLLQFIKEVKADHG--PNTHPLIIHCSAGVGRTGVVI
...| |.|   |.|. ..|...      || .  ..|| ||.||.|.|.
pieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 634-712 7.3e-19 62.7 In-house 218-295 (297) alignment 
Range on Protein: 634-712
Range on HMM: 218-295/297.0
IKEVKADHgPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
.. ..|.. |   .|..||||||||.|||.  | ...  .. |. ||  ... .|..|. .||| ||. ..| |||. |
leslraem.prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 641-707 3.9e-16 53.6 In-house 243-310 (319) alignment 
Range on Protein: 641-707
Range on HMM: 243-310/319.0
HGPNTHPLIIHCSAGVGRTGVVISIDSVVDHAKRT-RMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGA
.  .  ||..||| ||||||.||. |  . . . . | ||. . |  .|. |   |.|.|||.|||  
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 649-712 1.3e-14 48.4 In-house 2-65 (69) alignment 
Range on Protein: 649-712
Range on HMM: 2-65/69.0
IIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .   |  ..||.|| |  .|. || ||  . .| ||. |. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 649-712 3e-14 47.1 In-house 1-64 (69) alignment 
Range on Protein: 649-712
Range on HMM: 1-64/69.0
IIHCSAGVGRTGVVISIDSVVDHAKRTRMVDVFNFVTNIRQKRPYMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .   |  ..||.|| |  .|. || ||  ...| ||. |. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
0050432 (Phosphotyrosine protein) phosphatases II 708-1000 7.1e-76 250.8 In-house 8-301 (308) alignment 
Range on Protein: 708-1000
Range on HMM: 8-301/308.0
VLEDLLWRNTLILVIHFTDHLQDLHT-SVGGSGRSKMTKEFETLKSLCPdppPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILdSPDQDYINASQMKGV-
.|| ||.|.| |||.... ...||.    .  ..... .|||.| |..|   .  ..... |.|..|||| . ||. ..||.| ... |||||| ..|  
llelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgys

---HCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQND-KSCAQYWPDA---DSAQFGSYSVATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQ
    ..|  || |||.|| ||| ||   . ..||||..  .|. . ||||||.    .| ..| ..| .||. ...|.|.|....|  ... |.|||...
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfh

FHGWPKHGSDQQlgARSLIKLIRAVKSSTnnkKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
...|| ||  ..  ...|......|..|    ..  |.|||  | ||||.|...  .. |. ... ||.|..|| ||  |.. |||.| | |.|... ||
ytnWpdhgvPps..peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley

LHT
|..
lkl
0051299 (Phosphotyrosine protein) phosphatases II 717-998 9.3e-73 240.5 In-house 3-286 (288) alignment 
Range on Protein: 717-998
Range on HMM: 3-286/288.0
TLILVIHFTDHLQDLHtsvgGSGRSKMTKEFETLKSLCPDpppSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDQDYINASQMKG--VHCTFM
| | | ....... |.     .| ... .|||.| ||.||     ..... | |..|||| . ||. ..||.| .    .. |||||| ..|    ..|.
teisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI

TTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQND-KSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTR-----NSNASHTVTQYQFHGWPKH
 || |||.||.||| ||   . ..||||..   .. . ||||||. .| ..| ..| .||. ...|.|.|...||.      .. |.|||......|| |
atqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GSDQqlGARSLIKLIRAVKSSTNnKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|  .   ...|....|.|... . ...  ..|||  | ||||.|...  .. |. ... ||....|| ||  |.. |||.| | |||... |||
gvpd..spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 720-1002 1e-59 197.0 In-house 8-289 (293) alignment 
Range on Protein: 720-1002
Range on HMM: 8-289/293.0
LVIHFTDHLQDLHTSvggsGRSKMTKEFETLKSLCPDpppSRTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDQDYINASQMKGVHC--TFMTTQ
 . .|..|......        ....|.|.||..  |     . . ... |. |||| | || . .|| |    |....|||||. ..| ..   |..||
klekfeehvkkmkad....sdlrfseeyeelkavgkd...qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatq

MPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQYWPDA-DSAQFGSYSVATLSTSSDGDMTTRQMKVTRnSNASHTVTQYQFHGWPKHGSDQQlg
 |||.|| ||| ||  .| |.|||| .   . |  | .|||.  .. ..|. .|  .....  | ..|..|... ......|.||.|  || ||  ..  
GPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPek..

ARSLIKLIRAVKSST-NNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
...|....|.|.... .....  |.||| .| ||||.| .  . . .| | . |||| .|  || .|...||||..| |..... ..|....
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 721-1004 2.7e-66 218.8 In-house 4-286 (318) alignment 
Range on Protein: 721-1004
Range on HMM: 4-286/318.0
VIHFTDHLQDLHTsvggSGRSKMTKEFETLKSlCPDpPPSRTRSgRTPDNQPKNRYGNNLPLQRNRVILD----SPDQDYINASQMKGVH--CTFMTTQM
| .. .|.. |..    ||. ....|.| |.  ...  .....|  .| |. |||| | |. .. || |.    ... |||||. . | .   ... .| 
vedleshvrrlre....sGelllseeyerlsr.see.tvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqa

PLPTTVSDFWSMVVGSKPSTIVMLNDKSQ-NDKSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRN-SNASHTVTQYQFHGWPKHGSDQQLga
||| |..||| ||   . ..|||| ....   . ...|||. .| ..|.  |   .. . .|.. |..||||. ...| .| ||..  || .|. ..   
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg..

RSLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
 ||..|.| |..  .....  |.||| .| ||||||..    . .|.. . ||.||||| ||  |   ||||. | |.|||. |.|.. . |
aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte
subfamily_PTPRG_pd Subfamily PTPRG 721-1003 7e-55 181.3 In-house 3-292 (563) alignment 
Range on Protein: 721-1003
Range on HMM: 3-292/563.0
VIHFTDHLQDLHTSvggsGRSKMTKEFETLKSLCPDPpPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS-PD----QDYINASQMKGVH--CTFMTTQ
| .|. |. .||..    |  ....||| |.| . .     . . . |.|. |||| | .. .| || | . |.     |||||. ..| .    |..||
vkefakhvaslhad....gdigfseefealqsetisk.dldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatq

MPLPTTVSDFWSMVVGSKPSTIVMLND-KSQNDKSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKV-----TR--NSNASHTVTQYQFHGWPKHG
 ||..|. ||| |.   . ..|||. . . .. . | .|||  .| ..|. .|   ..      |.|....      .  . .  ..|.||..  || ||
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

SDQQlgarSLIKLIRAVKSSTNNKKEF-SILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
. ..    || .|| ..|||. ||.|   |.||| .|.||||...     . || . |.|..|...| .|| |   |||||.| |..|.. | . ... 
vPeh....slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 722-1002 5.8e-69 227.6 In-house 8-294 (298) alignment 
Range on Protein: 722-1002
Range on HMM: 8-294/298.0
IHFTDHLQDLHTSVGGSGRSKMTKEFETLKSLCPDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDQDYINASQMKGVHC--TFMTTQMP
 ... .|| | .     . .....||..|.|   . .   .. .|.|.|. |||| . ..|.  ||.| .     . |||||| ... .   .|..|| |
edlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaP

LPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRNS-NASHTVTQYQFHGWPKHGSDQQlgAR
|..||.||| ||.  . .|||||..  . ||  . .||||  ....|. .|  ||. . .|...|..||.... . ...| | .|  || .|  ..  |.
ltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpen..at

SLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
|...|.| |. |... .. ...|.| .| ||.| |.     . .. . ..||.||.||.||..|.. |||||.|.|.|... |.|.. |
svldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
subfamily_PTPN6_pd Subfamily PTPN6 722-1002 6.3e-57 187.9 In-house 7-301 (306) alignment 
Range on Protein: 722-1002
Range on HMM: 7-301/306.0
IHFTDHLQDLHTSVGGSGRSKMTKEFETLKSLCPDPPPSRtRSGRTPDNQPKNRYGNNLPLQRNRVIL---DSPDQDYINASQMK----GVHCTFMTTQM
 .  .. ..|. .    ... ...|||.|.        || . |. |.|. |||| | ||   .||||   . |..|||||...|    | ......|| 
keieqrvselekeeeslekagfeeefeelqqeeakkllsr.kegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqg

PLPTTVSDFWSMVVGSKPSTIVMLNDKSQN-DKSCAQYWPDADS-AQFGSYSVATLSTSSDGDMTTRQMKVT--RNSNASHTVTQYQFHGWPKHGSDQQL
 |.|||||||.||.  .   |||.  .     . ||.||||. .  ..|..|| ..| .|  | . |...|.  .... ...| ||.|. || ||  .. 
clettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdp

GAR-SLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAME---CIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
||  .... ... ......... .|.||| .| |||| |         | .      .|| ..||..|. | ..||||. | ||| .|..|..|..
gavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_PTPN9_pd Subfamily PTPN9 728-998 2.3e-50 166.3 In-house 3-290 (297) alignment 
Range on Protein: 728-998
Range on HMM: 3-290/297.0
LQDLHTSVGGSGRSKMTKEFETLKSlcpDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPD----QDYINASQMKGV--HCTFMTTQMPLPTTVS
...| . |   |.. ..||.. ...    |.  .    ... |  |||| . | ... || | . |     |||||. . |   . .|..|| ||. |||
ieelvayvkekgkrGlskeyaeirn...epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWSMVVGSKPSTIVMLNDKSQNDK-SCAQYWP--DADSAQFGSYSVATLSTSSDGDMTTRQMKVT-RNSNASHTVTQYQFHGWPKHGSDQQlgARSLIK
||| ||  ..  .|||     .. .  |.||||  . .||.||..||..... .  | ..|.....  . . | .|| .|| .|| .|  ..  | ||..
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPss..aaslld

LIRAVKSS------------TNNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
....|..             . . ..  |.||| .| |||| |.|   |.... | . ||...||| ||. |   .||.| |.| |  . || 
vlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0043336 (Phosphotyrosine protein) phosphatases II 730-998 5e-63 208.5 In-house 9-277 (278) alignment 
Range on Protein: 730-998
Range on HMM: 9-277/278.0
DLHTSVGGSGRSKMTKEFETLKSLCPdpppSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPD----QDYINASQMKGV--HCTFMTTQMPLPTTVSDF
..   .. ...... .|||.| |  .      .. .. |.|..|||| . ||. ..||.|.. .     |||||| ..|     .|  || ||| || ||
kallelllnlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedF

WSMVVGSKPSTIVMLNDKSQND-KSCAQYWPdADSAQFGSYSVATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDQqlGARSLIKLIRA
| ||   . .|||||..   .. . ||||||  .| ..| ..| .|.. ...|.|.|...||.  .. |.|||.|...||| ||        .|.....|
wrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..slsllldflka

VKSSTNnKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|..  . ...  .||||  | ||||.|...  .. |.  .  ||....|| ||  |.. |||.. | |.|....|||
vreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 730-1003 3.8e-36 119.2 In-house 16-288 (290) alignment 
Range on Protein: 730-1003
Range on HMM: 16-288/290.0
DLHTSVGGSGRSKMTKEF-ETLKSLCPDPPPSRTRSGRTPDNqPKNRYGNNLPLQRNRVIL-DSPDQDYINASQMKGVHCTFMTTQMPLPTTVSDFWSMV
 . ..|   .  ...||. |.||   |  .  |    . ..   |||| .    .. |||| |  | ||. |  .||.. .|. || .|  || |.| ||
kfasdvvkknvdelakeyleklkpylpvqylerkifdkntef.kknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmv

VGSKPSTIVMLNDKSQNDKS-CAQYWPDAD--SAQFGSYSV-ATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSdqqlgARSLIKLIRAV
.  | ..|||| .  .. |. |.||.|. .     ||...|  ..... | ..  . . |   .|  .| .  ..   || .       | | . |.| .
lqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv.....alstlallrtl

KSSTnnKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
..    |    . ||| .| |||| | .   ..  . .| ..|. ..|. ||  |.. || . .|  . ... ..    .|
rilr..kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky
0039614 (Phosphotyrosine protein) phosphatases II 731-998 1.6e-67 223.4 In-house 22-289 (297) alignment 
Range on Protein: 731-998
Range on HMM: 22-289/297.0
LHTSVGGSGRSKMTKEFETLKSLCPDpppsrTRSGRTPDNQPKNRYGNNLPLQRNRVILDS-----PDQDYINASQMKGVHC---TFMTTQMPLPTTVSD
|.     ...... .|||.|.|| ||     .. .. | |..|||| . ||. ..||.| .     .| |||||| ..| ..   .|  || ||| || |
llllekansktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetved

FWSMVVGSKPSTIVMLNDKSQNDKSCAQYWPDADSaQFGSYSVATLSTSSDGDMTTRQMKVTRnSNASHTVTQYQFHGWPKHGSDQ-QLGARSLIKLIRA
|| ||   . ..||||..   ... ||||||.  . ..| ..| .|..  ....|.|...||. .. |.|||..|..||| ||  .      ....|.| 
FwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvre

VKSSTnnKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
. ...  .|.  .||||  | ||||.|..|  .. |. ..  ||....|| ||  |.. |||.. | |.||...|.|
alael..pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 737-996 2.3e-63 209.0 In-house 17-277 (288) alignment 
Range on Protein: 737-996
Range on HMM: 17-277/288.0
GSGRSKMTKEFETLKSLCPDpppSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDQDYINASQMKGVHC--TFMTTQMPLPTTVSDFWSMVVGS
 ..|. ...|...| .|  .   . .  || . |..|||| | ||.  .|| |.     ...|||||| ..| .   ....|| ||. || ||| .|   
arnrtgfseeynsLaalekt...ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

KPSTIVMLNDK-SQNDKSCAQYWPDADS-AQFGSYSVATLSTSSDGDMTTRQMKVTRNSNaSHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSsTNN
| ||||||..   .... | .||||||   ..||  |  ...   .|...|.. . .. .   ..||||. .|| ||  ..  .. |..|.| ||  .|.
ktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkt.eleitqyqylaWpdhgvPes..kapllellrqvkv.anq

KKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
..   |.|||  | ||||.| ..   | .. | . .|.. ||. ||  |...|||.. | |.|.|. .
adtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
0047943 (Phosphotyrosine protein) phosphatases II 738-998 2.7e-69 229.0 In-house 9-272 (273) alignment 
Range on Protein: 738-998
Range on HMM: 9-272/273.0
SGRSKMTKEFETLKSLCPdppPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDQDYINASQMKG--VHCTFMTTQMPLPTTVSDFWSMVVGSKPSTI
.|.... .|||.|.||.|   .  .. .. |.|. |||| . ||. ..||.|.... |||||| ..|  .  .|. ||.||| || ||| ||   . ..|
lgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMLNDKSQNDK-SCAQYWPDAD---SAQFGSYSVATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDQ-QLGARSLIKLIRAVKSSTNNK
|||..  ....  ||||||.     | ..| ..| .||. ...|.|.|....|. ... |.|||.....||| ||  .      ..|.|.| . ......
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

keFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
    ..|||  | ||||.|...  .. |. ... ||....|| ||  |.  |||.| | |.|... |||
..gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 738-1006 7.2e-69 227.7 In-house 10-285 (297) alignment 
Range on Protein: 738-1006
Range on HMM: 10-285/297.0
SGRSKMTKEFETLkslCPDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDQDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKPSTI
...... ||||.|   .|  ..  .. .. |.|..|||| . ||. ..||.||... |||||| ..| .   .|. || |||.|| ||| ||   . ..|
lflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMLNDKSQNDK-SCAQYWPDA--DSAQFGSYSVATLSTSS--DGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDQqlGARSLIKLIRAVKSSTNNK
|||..  ....  ||||||.   .| ..| ..| .||...  ..|.|.|...||  ... |.|||.....||| ||  .   ..||...|..|..  .. 
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldfielvrkvlkll

-KEFSILVHCLSGAGRTGVFCTAMECIAQIA---EGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQR
 ..  .||||  | ||.|.|..|  .. |.    . . |||...|| ||  |.. |||.| | |.|... |.| . ..  .
psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep
0045450 (Phosphotyrosine protein) phosphatases II 738-998 3.3e-63 209.6 In-house 24-304 (307) alignment 
Range on Protein: 738-998
Range on HMM: 24-304/307.0
SGRSKMTKEFETLKSLCPDPpPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS-----PDQDYINASQMKG----------VHCTFMTTQMPLPTTVSD
...... ||||.|.|..... .  ..... | |..|||| . ||. ..||.| |     .| |||||| ..           .  .|. || ||| || |
dfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWSMVVGSKPSTIVMLNDKSQNDKS-CAQYWPDADSA-QFGSYSVATLSTSSDGDMTTRQMKVTR--NSNASHTVTQYQFHGWPKHGSDQQlgARSLIKL
|| |.   . ..||||..   ...  ||||||| ..  ..| . | .||.. ....| |...||.   .. |.|||.....||| ||  .     .|...
FwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps..feelldf

IRAVKSSTNNK-KEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNS---VDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|..|..  ..  |.  .||||  | ||||.|..|  .. |. ...    ||....|| ||. |.. ||..| | |.|....|.|
ieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 738-1000 2e-56 186.0 In-house 17-285 (290) alignment 
Range on Protein: 738-1000
Range on HMM: 17-285/290.0
SGRSKMTKEFETLKSlcpDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILD--SPDQD----YINASQMKG--VHCTFMTTQMPLPTTVSDFWSMVVG
 |.... ..|..|.|      .  .  | |..|...||. | .. . ||..|   | ..|    ||||. .||   .  .. || |.. |. |||.... 
kgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwq

SKPSTIVMLND-KSQNDKSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRNSN--ASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSST
 | . |||| . .... . | |||||.|....| .|.  |. ..  ....|...|. ...  |...|||||.  |...|. ..    . . .|. .    
ekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtn..pqtillvieemyktq

NNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
  . . ||.|||  . ||..|||.|.  | .      .|.|| .| .|  ... |||...| ...... .||..
rkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 739-1003 1.5e-59 196.7 In-house 21-288 (319) alignment 
Range on Protein: 739-1003
Range on HMM: 21-288/319.0
GRSKMTKEFETLKSLCPDpppsRTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDQDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKP
|  .. |||..||   .|     ..|  ...|..|||| | |. .| ||.|    .... |||||| . | .    |. || || .|..||| ||   . 
getllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

STIVMLNDKSQNDK-SCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRNSNAS--HTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNK
|..|||.. ... |  . .|||...  ..| . |  ..     |.  |..|. ..|.     .|...|.  || |.  ..  |.||..|.. .. |....
sivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek..atslldllkrirksrekt

KEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
..  | |||  |.|||| |..    . .. | . .|.|.||. ||. |   ||..| | |.|....|.... . 
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt
subfamily_PTPN23_pd Subfamily PTPN23 739-1000 1.1e-52 173.7 In-house 13-282 (288) alignment 
Range on Protein: 739-1000
Range on HMM: 13-282/288.0
GRSKMTKEFETLKSLCPDPppSRTRSGR-TPDNQPKNRYGNNLPLQRNRVILDSPDQDYINASQMKGVHC---TFMTTQMPLPTTVSDFWSMVVGSKPST
|.... |.|. |..       .| ||      .  |||. . ||  .||| |..   |||||| .|..     .|..|| ||..|..|||.||.  | |.
gktaldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLNDKSQNDK-SCAQYWPDAD--SAQFGSYSVATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKS---STN
|||| .|.. .| ....||| .   . .|| .||.  |. . . .  |..|..  ...| ..|.  |.. ||..|  .     .|.... .|.|   ...
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPas..Petllqfldevesayeavq

NKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSV-DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
.| .  ..|||..| ||||||.  .  .... .|| . || | |. ||..|   ||..|.. |.|... |. . 
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 739-1008 3.9e-28 93.3 In-house 14-290 (307) alignment 
Range on Protein: 739-1008
Range on HMM: 14-290/307.0
GRSKMTKEFETLKSLCPDPPPSRTRSgrtpDNQPKNRYGNNLPLQRNRVILDSP--DQDYINASQMKGV--HCTFMTTQMPLPTTVSDFWSMVVGSKPST
| .... ||. |    |.  .  . |     |. |||| .    ...|...  .    ||| |  .        |. .| || .|. .||.|..  |  .
gvqalvdefrvlakktpegvtveafs....antdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

IVMLNDKSQNDK-SCAQYWPDADS--AQFGS----YSVATLST---SSDGDMT-TRQMKVTrNSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVK
..|| .  .  |  | ||||  .     ||.     ||| | .   . | |.    ..||   .. | |....|.. || .|  |     . | |. ||.
vimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvd.waqksrtiqhlqwenwpdrgvpqi..nltainlleavr

SSTNnkkefSILVHCLSGAGRTGVFCTAMECIAQI-AEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL---HTENYEQRPY
  ||      ..||| .| ||.|   .      .. |  |  |. . |. ||..|   .||| .| ... |. ||.   . | ||.   
ydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeelll
subfamily_PTPRN_pd Subfamily PTPRN 740-996 3e-39 129.5 In-house 28-290 (297) alignment 
Range on Protein: 740-996
Range on HMM: 28-290/297.0
RSKMTKEFETLKSLCPDPppSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDQDYINASQMKG---VHCTFMTTQMPLPTTVSDFWSMVVGSKP
.... ||.|.|..   .|  | .  .....|  |||. . || . .|| |..     ..||||||..      . ....|| ||..||.||| ||  .  
kdrlekewealcayeaep..stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

STIVMLNDKSQN-DKSCAQYWPDADSAQFGSYSVATLSTSSD-GDMTTRQM--KVTRNsNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNN
  ||.|   ...  | |..||||  |. .. | |  .|      |   | .  |  .. . . ||||. |  ||..|   .  |.||... | |  |   
vvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqt.setrtvtqfhflswpeegvPas..aksllefrrkvnksyrG

kKEFSILVHCLSGAGRTGVFCTAMECIAQIAEG-NSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
 .  .|.||| .|||||||..     ..... | . .||  |.. || .| ..|.|.... |.. .. |
.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0040438 (Phosphotyrosine protein) phosphatases II 741-1000 4e-66 218.8 In-house 18-277 (317) alignment 
Range on Protein: 741-1000
Range on HMM: 18-277/317.0
SKMTKEFETLKSLcpdP-PpsRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPD----QDYINASQMKGV--HCTFMTTQMPLPTTVSDFWSMVVGSKPS
 .. .|||.| ||   . .   .. .. |.|..|||| . ||. ..||.| ...     |||||| ..|     .|  || ||| || ||| ||   . .
talleefedllsl...kld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

TIVMLNDKSQN-DKSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDQqlGARSLIKLIRAVKSSTNnKKE
.||||..  .. .. ||||||. .. ..| ..| .||.  ....| |...|.  ... |.|||.....||| ||  .    ..|.....||... . ...
vivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spdllldfleavreale.dpg

FSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLhT
  .||||  | ||||.|..|  .. |. ... ||....|| ||. |.. |||.| | |.||...||| .
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl.k
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 741-1002 2.6e-40 133.0 In-house 15-297 (301) alignment 
Range on Protein: 741-1002
Range on HMM: 15-297/301.0
SKMTKEFETLKSLCPdpppSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPD------QDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKP
 |. .....||.  .     ..  | . .|.. ||. |. ... ||.||          ..||||| ..|.     |. .| |.  |. ||| ...  ||
nkfeeqykelkeged....ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

STIVMLNDKSQN-DKSCAQYWPDA--DSAQFGSYSVATLSTSSDGDMTTRQMKVT--RNSN--------------ASHTVTQYQFHGWPKHGSDQQlgAR
..|||. .. ..  ..| ||||..  .| .||  .|   ..    |.. ||..|.    ||              .|..|.|.|   ||..|  ..   |
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre..pr

SLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
  .. |  |   ..      ..|||  . .|.||.|.    . |      ||.|| .| .|  ..  |.| | | ..|||| .||. ..
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 741-998 3.2e-34 113.1 In-house 20-279 (439) alignment 
Range on Protein: 741-998
Range on HMM: 20-279/439.0
SKMTKEFETLKSLCPDPPPSRTRSGRTPDnQPKNRYGNNLPLQRNRVIL----DSPDQDYINASQMKGVHC--TFMTTQMPLPTTVSDFWSMVVGSKPST
  ....||...|  ||     .   .  | |.|||| .  ...  ||.|      |   ||||  .|| .    ...||.|   |. ||| .|.  | .|
eifkeifekinstspdyaciaslaaqeyd.qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvt

IVMLNDKSQNDKscaqYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRNS---NASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNKKE
|||| .  .  |    |||  . . .|  .| .       . . | .||  .    .  .|| |...  ||..    |  |  .....||..|. .... 
ivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeey

FSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  ..||| .| ||||   .   .. |.   | |||   ||.|| .| |.||.  .| |.|. . | .
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 741-998 5.4e-34 112.4 In-house 6-259 (267) alignment 
Range on Protein: 741-998
Range on HMM: 6-259/267.0
SKMTKEFETLKSLCPDPppSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDQDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKPSTIVML
 .. |||| .| . ..   |.     . .|| .||. .||| . .||||   ...||||| ..| .   .|. || ||  |..||. ..   | ..||.|
ceiekefelikkisdts..stisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NDkSQNDKsCAQYWPDA--DSAQFGSYSVATLSTSSDGDMTTRQMKVTRNSNASHTVTQYQFHGWPKHGSDQQLgARSLIKLIrAvKSSTNNkKEFSILV
   .  |.   ..||    .. ..   .|       . |     ...  . ...| || | .. |     ..    . |. .. | |   .|  .  ..|
tk.vftdn.irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpy.lkplfgil.a.knqlen.gnrPlvv

HCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.|  | ||.| | ..   . .. . . .|||. .. .|  |. .|.| |.| ...... || 
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 742-1002 8.4e-54 177.5 In-house 21-282 (287) alignment 
Range on Protein: 742-1002
Range on HMM: 21-282/287.0
KMTKEFETLKSLCPDppPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDQDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLN
  .. | .|...  .  .     . ...|..|||. . |. . .||.|   ..|||||. ..| .    |. .. |.  |. .|| ..   ....|||| 
gfknqftvleqvtqr..edevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlc

DKSQN-DKSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRNS--NASHTVTQYQFHGWPKHGSDQQLgARSLIKLIRAVKSSTnNKKEFSILV
.. .| .. | ||||. .|  .| |... |.     ... |...|....  .. ..|.|||.  |...|  ..  . .|. . . .|.    . . ||.|
qekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep.qtillvieemyktqr.krgntsivv

HCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
||  . ||...|| |   | .  .   .|.|| .|  |  ... ||| |.| |..|.. |||.. .
hCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 742-1001 3.9e-37 122.6 In-house 11-280 (287) alignment 
Range on Protein: 742-1001
Range on HMM: 11-280/287.0
KMTKEFETLKSLCpDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPD---QDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKPSTIV
.. ||...||    .  .   ..     .  ||||.. ||.  .||.|        |||||  . . .   .|...| |...|| ||| .|.  . ....
dvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

ML-NDKSQNDKSCAQYWPDADS-AQFGSYSVATLST-SSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAV----KSSTNN
..  .  .  . | .|||. .   . | |||  |.    . . ..| ...   ... .. | |...  ||...      | .||...  |    . . . 
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPt..avglirfvldvkqhielarda

KKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
..   ..||.  |.||.|.. . . .. .  .   ||. ..|  ||  |  .||.   . ..|. .  | .|.
sevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 742-1005 1.8e-24 80.9 In-house 25-295 (305) alignment 
Range on Protein: 742-1005
Range on HMM: 25-295/305.0
KMTKEFETL-KSLCPDPPPSRTRSGRTPD-NQPKNRYGNNLPLQRNRVILDSPD-QDYINASQMKGV---HCTFMTTQMPLPTTVSDFWSMVVGSKPSTI
|. .||  | |   ||       . ...| .. |||| .    ... | || |   ||| |  .      .  |. .| ||  |. .|| ||.  |   |
klreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqi

VMLNDKSQNDK-SCAQYWPDADSAQFG---SYSVATLSTS----SDGDMTTRQMKVTRNSNASHTVTQYQFHGWPKHGSDQQlGARSlIKLIRAVKSStn
|||    .  |  |||||| |   .        |  .| |     | ..    ...| . . . .| . |.  ||  |        | ..|. |.. |  
vmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc.klts.lellsairgs..

nkkEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSV-DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHtENYEQ
   .  |.||| .| ||||   .    . .||| ...  . . || || .|   .|.. .| |.. |. .|.  |.| .
...kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl.ekyke
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 743-1004 6.3e-87 286.4 In-house 23-290 (297) alignment 
Range on Protein: 743-1004
Range on HMM: 23-290/297.0
MTKEFETLKSLCPdpPPSRTRSGRTPDNQ---PKNRYGNNLPLQRNRVILD----SPDQDYINASQMKGVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTI
.  .... . ||.  | . .... . ...   .|.|| | || ...||.|     .|| ||.||| .||..  ..||||| ..|| ||| ||.  ..|||
rhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvsti

VMLNDKSQNDKSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRNS-NASHTVTQYQFHGWPKHGSDQQLGARSLIKLIRAVKSSTNNKKEFSI
|||||....||.||.||.|  ...||. || .||.|.   .  |...||...  | . | ||||  ||..  ...  |.||.|||  |. . ....|  .
vmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPl

LVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
|||||.| |||||..|  ...|.. . ..||||..|| || .|...|||.|.|.||| .. |.| .|...
lvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
0046845 (Phosphotyrosine protein) phosphatases II 743-1000 1.3e-71 236.6 In-house 2-276 (284) alignment 
Range on Protein: 743-1000
Range on HMM: 2-276/284.0
MTKEFETLKSLCPDPPpSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS-----PDQDYINASQMKGV-------HCTFMTTQMPLPTTVSDFWSMVVGS
. .|||.| || ...    .. .. | |. |||| . ||. ..||.|.|     .| |||||| ..|        ...|. ||.|||.|| ||| ||   
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPSTIVMLNDKSQNDK-SCAQYWPDAD-SAQFGSYSVATLSTSSDGDMTTRQMKVTRN--SNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSST
. ..||||..  .|..  ||||||. . . ..| ..| .||.  ..|.|.| ...|..  .. |.|||......|| ||  ..  ...|....|.|... 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrell

NN-KKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGN---SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
.| ...  |.|||  | ||||.|.... .. |. ...    ||....|| ||  |...|||.| | |||... ||| .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
DSPc_SM00195 743-998 3.4e-71 235.0 In-house 2-262 (263) alignment 
Range on Protein: 743-998
Range on HMM: 2-262/263.0
MTKEFETLKSLCPDPppsRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPD----QDYINASQMKG--VHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIV
. .|||.|..  ..    .|.... . |. |||| | || ...||.|....    .|||||. .||     ..  ||.|||.||.||| ||.  | ..||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKSQ-NDKSCAQYWPDA--DSAQFGSYSVATLSTSSDG-DMTTRQMKVTRNS-NASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNKkE
||.. .. . . |..|||.   .. .||..|| . .. ..  ....|....| .  . ...|||||...||.|| ...  ..|...|.||||.|.... .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpds..tksvlellravkksksts.s

FSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.|.|..| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 743-998 3.4e-71 235.0 In-house 2-262 (263) alignment 
Range on Protein: 743-998
Range on HMM: 2-262/263.0
MTKEFETLKSLCPDPppsRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPD----QDYINASQMKG--VHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIV
. .|||.|..  ..    .|.... . |. |||| | || ...||.|....    .|||||. .||     ..  ||.|||.||.||| ||.  | ..||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKSQ-NDKSCAQYWPDA--DSAQFGSYSVATLSTSSDG-DMTTRQMKVTRNS-NASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNKkE
||.. .. . . |..|||.   .. .||..|| . .. ..  ....|....| .  . ...|||||...||.|| ...  ..|...|.||||.|.... .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpds..tksvlellravkksksts.s

FSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.|.|..| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Ptp69D_pd Subfamily Ptp69D 743-1002 4.3e-54 178.7 In-house 24-290 (307) alignment 
Range on Protein: 743-1002
Range on HMM: 24-290/307.0
MTKEFETLKSLcpdPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDQDYINASQMKGV--HCTFMTTQMPLPTTVSDFWSMVVGSKPSTIV
..||.|.|..      .  |. .   .|. |||| .  .  ..||.|       | |||||| .||   . .|.. | |. .|. ||| |.   .  .||
lakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLNDKSQNDK-SCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRNS------NASHTVTQYQFHGWPkhGSDQQLGARSLIKLIRAVKSSTNNK
|| . .. ..  ||.|||. |  |.|.  | . |... .| . |...|...       ..|. |.||.. ||.   |     ||.|.|||. |..  ...
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk..DskvPevargllklieqvrelykln

kEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 .  |.|||  |.||.|.| .    . |. . ..||||.||| || .|  .||  | | |.|  . .| .  .
.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 743-1000 4.6e-50 165.3 In-house 17-278 (281) alignment 
Range on Protein: 743-1000
Range on HMM: 17-278/281.0
MTKEFETLKSLCPDPPpsrTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDQDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKPSTIV
...|.|.|...  | .   ... ....|. |||| |       || .    .. . |||||. ..|..    ...|| |.|... .|| ||.  | |.||
fieeyeklaaigvdnt...ataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLNDKSQNDK-SCAQYWPDAD-SAQFGSYSVATLSTSSDGDMTTRQMKVTRNSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNKKEFSI
|.  . ...|  | .|||| . . ..| . | ......   . .|..|..|.|. . .|.| ..  || ||  ..  .. |..  ..|.. |..|.. ..
mvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPat..tkellefrkevlkltekktkapl

LVHCLSGAGRTGVFCTAMECIAQIA-EGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
..|| .| ||||.. .    . ... | ...|. ..|. || .|. .|||   |.||| .. ..|. 
vihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 744-1001 1e-64 213.6 In-house 21-286 (305) alignment 
Range on Protein: 744-1001
Range on HMM: 21-286/305.0
TKEF-ETLKSLCPDppPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDQDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKPSTIV
.|.. .  |||. .  .. .  |..  |. |||. .. .|. .|.||      .|.|||||| ..| .   .....| ||..||.||| ..|  |.||||
dkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLN-DKSQNDKSCAQYWPDADSA--QFGSYSVATLSTSSDGDMTTRQMKVTR--NSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNKKE
||   . .... | ||||.. .   .||..||   |...  | ..|..|..   ... |.||.|||.  || ||  |.  | ||..||. |. . .. |.
mltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf..atsllslikrvqkdqkkdkg

FSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 ..||||  | ||||||..    . .. . ..||.|. .| ||  ||. ||| ..| |..|.. |.... 
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_PTPN12_pd Subfamily PTPN12 744-1000 5.3e-53 174.8 In-house 11-279 (290) alignment 
Range on Protein: 744-1000
Range on HMM: 11-279/290.0
TKEFETLKSLCPDPPP---SRTRSGRTPDNQPKNRYGNNLPLQRNRVILD----SPDQDYINASQMKGV--HCTFMTTQMPLPTTVSDFWSMVVGSKPST
.|||..||.|          .| .|... |. |||| . || . .|| |     ....|||||. .|||  ..... .| |||.|..||| |.   . . 
akefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknvei

IVMLNDKSQNDK-SCAQYWPDA--DSAQFGSYSVATLSTSS-DGDMTTRQMKVTRNsNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNnKK
.||.  .  ..|  |..|||.   .. .||...| . .    | |.. |..||... ..|..|.|.... || ||  ..  | ||..||..|..  . ..
vvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPss..aksllelielvrelqe.se

EFSILVHCLSGAGRTGVFCTAMECIAQI---AEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
.  ..||| .| ||||. ..      ..      ...|.|. |  || .|   |||.| | .||  . |....
daPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_CG7180_pd Subfamily CG7180 744-999 1.4e-46 153.5 In-house 16-291 (296) alignment 
Range on Protein: 744-999
Range on HMM: 16-291/296.0
TKEFETLKSLCPDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS----PDQDYINASQMKGV--HCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVM
  |.. .  | |       . |   .|. |||. . .|   |||.|..     ..|||||. . .   .  .. |..|   || .||..|   . |..|.
rveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvv

LNDKSQNDKSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRN-----------SNASHTVTQYQFHGWPKHgSDQQLGARSLIKLIRAVKSST
| .. .  | . .|||    .|.|   | .... .  ....|..|.|..           .    .|...|.  |. .     | . .||.|.| |..  
LtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWele.dkvPlstnalielrrrvrlwr

NNK----KEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
..     .|  ..|..  ||.|.||....  .. .. . . ||.|. || || .| | |.. ||| ..|||. |.. 
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPN13_pd Subfamily PTPN13 744-999 1.5e-45 150.6 In-house 14-270 (273) alignment 
Range on Protein: 744-999
Range on HMM: 14-270/273.0
TKEFETLKSLCPDpppSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDQdYINASQMKGV----HCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLN
..||..|. | |     ....|.. .|. |||| | || .. ||.|..    ||||| .|      . ... .| |||.||.||| ||   | . |.|. 
aeefkelrelkpl...dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

-DKSQNDKSCAQYWPDADSAQFGSYS---VATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNnkKEFSI
 .| ..   | .|||.  . .   ..   |. | .    ... |...|.  .|..|. |.. .|  || ||  ..  | .|..... |..  .  ..  |
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss..aaellqfvaevrrlqt..dagPi

LVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
.||| .| ||.|.. |    .  |.  ...|. ..|. ||  |   |||.. | ||| .| | |.
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 746-1003 5.7e-17 56.3 In-house 27-284 (303) alignment 
Range on Protein: 746-1003
Range on HMM: 27-284/303.0
EFETLKSLCpdpPPSRTRSgRTPDNQPKNRYGNNLPLQRNRVILDspDQDYINASQMK-GVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQN
||| . |     ||| ..  .  .|  |||. . . |.  .| |   |  || || ..   .   . ||.||. | .||| |..  |   ...|   |. 
efekvvsyl...ppsvskn.qfvknmdknrfvdvicldhskvkls..dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdsey

DK-SCAQYWP-DADSAQFGSYSVATLSTSSDGDMTTRQMKVTRNSNASHT--VTQYQFHGWPkHGSDQQLGARSLIKLIRAVKSSTNNKKEFSI-LVHCL
||      .| . |  .|   |.          .   ..||   || ..   .  .... || |.|    |.  ..| |  ..|   .  . .  .   |
dklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawp.hnsipsdgspkfvkqiwqlqsvlrkysdstptvymsl

SGAGRTGVFCTAM-ECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
|| ||.| |.      ..  .| .|.|. . .. .|  |.. ||   ....|| .. |..  . .
sgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 747-996 1.8e-49 163.1 In-house 12-264 (283) alignment 
Range on Protein: 747-996
Range on HMM: 12-264/283.0
FETLKSLCPdpPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDQDYINASQMK-----GVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDK
.|.|| |.   |.  .    . .|..|||. . .| ...|| |.|  .|||||. .           .. .| ||  || ||| ||   | ..||||   
revlkrlsv..pdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltkl

S-QNDKSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTRNSNASHT--VTQYQFHGWPKHGsdQQLGARSLIKLiRAVKSSTNNKKEFSILVHC
  .... |.||||   | ..| . |.     .   .. ... .  || |  |  .. ||. .| . |  .|    ||.|.   |.|  ...|.  |.|||
qedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg..eqaiinslvkf.nkvislqteskkgPivvhC

LSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
 .| |||.||..|.  . ..     ||.|..|||.| .||  ||| . | .|.... |
stgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 750-997 9.1e-19 62.2 In-house 17-268 (281) alignment 
Range on Protein: 750-997
Range on HMM: 17-268/281.0
LKSLCPDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDS--P---DQDYINASQMKG--VHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDK-
.  |  |||         | |. |||| |   |.  || |    |     ||| |  ..   ..  .. || |   | .||| |.   . ..|||| .  
fsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfl

SQNDKSCAQYWPDAD--SAQFGSYSVATLSTSSDGDMTTRQMKVTRNSNaSHTVTQYQFHGWPKHGSDQqlGARSLIKLIRAVKSSTNnkkefSILVHCL
  | . ||.|.|       ||  .||.   .. .  . | ..... . . .. .|.. .. ||     .   .  ..|..| ... .        ..|| 
etnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyege.trlithwlwkewpdwqvpe..ssevmlkilrkirarst.....ppvihcs

SGAGRTGVFCTAMECIAQIAEG-NSVDIFQTVKILRA-DRMQFVQTEEEYAFVYDVIREY
.| ||.| . .   ..  |       || | |  ||   |   ||| ..| ... |. ..
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 753-1002 5.9e-56 184.9 In-house 31-292 (325) alignment 
Range on Protein: 753-1002
Range on HMM: 31-292/325.0
LCPDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDQDYINASQMKGV--HCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK
| |   .   .    |.|. |||. | ..|...||.|    |.|. |||||| ..      .|...|.||..|. |.| .|.  . | .|.||   ....
llpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkd

SCAQYWPDA--DSAQFGSYSVATLSTSSDGDMTTRQMKVTRNSNA-SHTVTQYQFHGWPKHGSDQQLGA-RSLIKLIRAVKS--STNNKKEFSILVHCLS
.||.|||.   .| .||.  |   .     |   |...| . ..  . .| |.|. .|.  | ...  .  |...|. ||.    .| |    ||||| .
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
| |||||| .    .|.. |  .||||. || ||.|| . |.| ..| ..|. . |.. . |
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 753-998 4.1e-46 152.8 In-house 43-292 (319) alignment 
Range on Protein: 753-998
Range on HMM: 43-292/319.0
LCPDPPPSRT-RSGRTPDNQPKNRYGNNLPLQRNRVILDSPD----QDYINASQMKGVHC--TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNdksqnD
.|  ...  .      ..|. |||..| |.  .|.| |.  .     |||||| ..|      ....| ||. |. ||| |.  .. ||||.|       
acklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.....k

KSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTR--NSNASHTVTQYQFHGWPKHGSDQ-QLGARSLIKLIRAVKSSTNNKKefSILVHCLSGA
. |.||||     . . . |   |     . . |......  . .    .||. | |||..|  .       |.| .| ..|  |...  .|.||| .|.
dkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra..nivvhcsaGv

GRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE-YL
|||||. .    . .. | . ||....|. || .| ..||   .| |.|  . | .|
GrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
0045098 (Phosphotyrosine protein) phosphatases II 754-999 1.1e-60 200.7 In-house 17-273 (278) alignment 
Range on Protein: 754-999
Range on HMM: 17-273/278.0
CPDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVIldspdqDYINASQMKGVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQN-DKSCAQYW
 . ..||.   .  ..|..|||| . ||. ..||.      |||||| ..| . .|  || |||.||.||| |.   . ..||||..  ..  . |||||
lllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PDADSAQFGSYSVATLSTSSDGDMTTRQMKVTR-----NSNASHTVTQYQFHGWPKHGSDQQLGARSLIKLIRAVKSSTN------------NKKEFSIL
|. .| ..| ..| .||..  .|.|.| ..||      ... |..||......|| ||.  .   .|...|.. ...  .            . ..  .|
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

VHCLSGAGRTGVFCTAMECIAQIaeGNSVDIFQTVKILRADRMQ-FVQTEEEYAFVYDVIREYLH
|||  | ||||... |. .. ..  .. ||....|| ||  |..  ||..| | |.|....|.|.
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_ptpA1_pd Subfamily ptpA1 754-954 9.1e-32 105.3 In-house 31-252 (418) alignment 
Range on Protein: 754-954
Range on HMM: 31-252/418.0
CPDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDQDYINASQMKGVHC-TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-S
     || |  |    |  |||| | ||... || |    |    |||||  . | .   |. || ||| |..||| ||   .   ||||. .|.| .  
eesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrik

CAQYWPDAD-----------SAQFGSYSVATLSTSSD--GDMTTRQMKVTRNSNAsHTVTQYQFHGWPKHG-SDQQLGARSLIKLIRAVKS--STNNKKE
| .|||.                ||.|||  .    |   .. ||....| . .. . .||||. ||| |   |.    | |.. |   .     .. ..
cdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeget.rditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrn

FSILVHCLSGAGRTGVFCTAMEC
  |.||| .| |||| ||||.  
vpiivhcsagvgrtgtfctavim
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 755-1002 1.1e-131 433.4 In-house 29-281 (315) alignment 
Range on Protein: 755-1002
Range on HMM: 29-281/315.0
PDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDQDYINASQMKGVHC--TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-S
|||...|.|..|...|..||||.|.|||...||.|    ||||.||||||..|.|..  .....|.||...|.|||.||...|..||||...|...|| .
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CAQYWPD--ADSAQFGSYSVATLSTSSDGDMTTRQMkVTRNSNASHTVTQYQFHGWPKHGSDQQLGarSLIKLIRAVKSStNNKKEFSILVHCLSGAGRT
|.|||||  |||..|||..|..||...|.|...|.. |||.|..|.||||.||..||..|.|.|..  ||.|||..||.. |.|||||.||||..|.|||
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrt

GVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
||.....|..|||....|||.|..||.|||.|...|||||||||.||...|.|.  |
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 755-860 1.6e-33 110.6 In-house 30-150 (392) alignment 
Range on Protein: 755-860
Range on HMM: 30-150/392.0
PDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDQDYINASQMKGVHC--TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLND-----KSQ
|.|. ..........|..||||.|.||....||.|    |.||.||.|||.......  .....|.| .....|||.||   ...||.|...     | .
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgd

NDKSCAQY----WPDADSAQF
.....||.    |||.|  ..
dartvaqfhftewPdkdvpkh
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 755-906 3.4e-14 47.0 In-house 81-235 (244) alignment 
Range on Protein: 755-906
Range on HMM: 81-235/244.0
PDPPPSRTRSGRTPDNQPKNRYGNNLPLQRNRVILD--SPDQDYINASQMK--GVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDkscaQ
  | ||  .    |.|  ||| |  ||.. ||| |   |  . ||||| .   |  . .. || ||  |  ||| |..  .   .|.|    ..|    .
irpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....e

YWPDADSAQFGSYSVATLSTSSDG--DMTTRQMKVTRNSNASHT-VTQYQFHGWPKHGS
||||..  ..    ..   |  |   .. . ....  . | ||  .| .|   ||  |.
ywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_PTPRD_pd Subfamily PTPRD 758-1004 1.8e-70 233.2 In-house 36-287 (564) alignment 
Range on Protein: 758-1004
Range on HMM: 36-287/564.0
PPSRTRSGRTPDNQPKNRYGNNLPLQRNRVIL----DSPDQDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQ
. ..... . | |..|||| | ..  ..||.|      .. |||||| ..| .   ... || ||..|..||| ||   . ||||||.  . ..|  |..
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVT-RNSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTnNKKEFSILVHCLSGAGRTGVFC
|||. .....|.. |   ..    |.. |..|..  .|. |..|.|..|  || ||  ..  |.||..||| |.... ....  |.||| .| ||||.|.
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes..atslLdlirkvraln.epdagPivVhCSaGVGRTGtfi

TAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
.   .. .| | . |||.|.|| ||..|   ||||| |.|....| |.|.  | |
vidamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_PTPN14_pd Subfamily PTPN14 759-999 7.6e-44 144.9 In-house 38-297 (300) alignment 
Range on Protein: 759-999
Range on HMM: 38-297/300.0
PSRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSP---DQDYINASQMK----GVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQ
 . . ... |.|..|||. . || . ||| | .    ...|||||..|    | . .....| ||..|| ||| ||  .. . |||| .. .. |  . .
dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPDA----DSAQFGSYSVATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDQQL-GARSLIKLIRAVKSSTNNKK-----EFSILVHCL
|.|.     ....|| . | |  ... . ..|...|.    |.   ||   |.  ||.||  . . |  | .. ...|.  ||...     .  .||||.
yfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

SGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
 |.|||||  ..   || .  ....|| .....||  || .|||   | |||.|. .||.
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN3_pd Subfamily PTPN3 760-995 1.7e-47 156.7 In-house 31-272 (280) alignment 
Range on Protein: 760-995
Range on HMM: 31-272/280.0
SRTRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDQDYINASQMK----G--VHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQYW
  .   | |.| .|||| . ||    ||.|.. ..|||||. ..    .  .   ...|| ||..|..||| ||   | |.|||| .  .. .  | |||
laisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PDA-DSAQFGSYSVATLSTSSDGDMTTRQMKVTRNS-NASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNkKEFSILVHCLSGAGRTGVFCT
|.  |. ..|..||   .....  . .|.. ..... . .....| |.  || ||  ..  . ....... |..  .  ||  ..||| .| |||||. .
PetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdd..sadflefvervrklrsg.keePvvvhCsaGigrtGvlil

AMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
   ..| | . ..| . . |. .|  |. .|||.. | || . | 
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPN1_pd Subfamily PTPN1 762-996 9.5e-39 127.8 In-house 24-269 (290) alignment 
Range on Protein: 762-996
Range on HMM: 24-269/290.0
TRSGRTPDNQPKNRYGNNLPLQRNRVILDSPDQDYINAS--QMKGVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQ-NDKSCAQYWPDAD--
||. ..| |...||| .  | .  |..|.. |.||||||  ... ..  .. || ||| ||. || ||   |  ..||||   . .   ||||||  .  
treaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeee

-SAQFG--SYSVATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSST-NNKKEFSILVHCLSGAGRTGVFCTA
 . ..   ...|  .|. .    | |.....  ... ....... .  ||  |  .     ...|..  |..|   ...    ..|| .| ||.| || .
kellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpes..paaflkflfkvresGslssdvGpavihcsaGiGrsGtfclv

MECIAQIAEGN---SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
  |...| . .   |||| ...  ||  |. ..|| .   | |  | |
dtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 763-994 7.8e-28 92.2 In-house 26-291 (297) alignment 
Range on Protein: 763-994
Range on HMM: 26-291/297.0
RSGRTPDNQPKNRYGNNLPLQRNRVILD--SPDQDYINASQMK----GVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQND-KSCAQYWPDA
 | . .    |||| . |  . .|| |    ...|||||  .          .. .| || .|| ||| .|.     .|||.    ..  . || |||..
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

DSA--QFGSYSVATLSTSSDGDMTT--RQMKVTRNsNASHTVTQYQFHGWPKHGSDQQLG--ARS-------------LIKLIR--------AVKS-STN
.    . |.. |  ||. ||   .    ....    . |  |.  || .|| ||   .|    |              .. |.          ..|  ..
vqerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslrae

NKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
  ..  .|||| .| ||.||   ..  .|..  .   |.   ..|||  | . ||| |.. ..||..
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
0040439 (Phosphotyrosine protein) phosphatases II 764-998 4.8e-57 188.7 In-house 5-246 (249) alignment 
Range on Protein: 764-998
Range on HMM: 5-246/249.0
SGRTPDNQPKNRYGNNLPLQRNRVILDS----PDQDYINASQMKGV--HCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQN-DKSCAQYWPDAD
 .. | |..|||| . ||. ..||.| .    .. |||||| ..|     .|  || ||| ||.||| |.   . ..||||..  ..  . ||||||. .
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SAQFGSYSVATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDqqLGARSLIKLIRAVKSSTNNK-KEFSILVHCLSGAGRTGVFCTAMEC
| ..| ..| .||. . .|.|.|....|.   . |.||...|...|| ||        .|...|.||..  ..  |.  .||||  | ||||.|..|  .
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvp..psfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
. |. . . ||....|| ||  |.. ||..| | |.|....|.|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0049772 (Phosphotyrosine protein) phosphatases II 764-999 1.2e-30 102.7 In-house 40-281 (314) alignment 
Range on Protein: 764-999
Range on HMM: 40-281/314.0
SGRTPDNQPKNRYGNNLPLQrNRVILDS---PDQDYINASQMKGVhCTFMTTQMPLPTTVSDF----------WSMVV--GSKPSTIVM-----------
 .. . |. |||| . ||   |||||..    . |||||| ..|. ..|. || ||. || ||          |.||.    .. .|||           
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LNDKSQNDkscaQYWPDADSAQFGsysvatlstssdgdmttrqMKVTRNSNASHTVTQYQFHGWPKHGSDQQLGARSLIKLIRAVksstn
          |.. . |      ... || ...                      .. ..  .... .|  . .| .. .     ......|...     
rLdaAlgKtpllildgng....neptaadlellk...................eelydpelferlgikylripvpDgsaplledfdeflefieea.....

nKKEFSILVHCLSGAGRTGVFCTAMECIAQIaegnSVDIFQTVKILRADRM-----QFVQTEEEYAFVYDVIREYLH
 .|.  .|||| .| ||||.|..|. .. .      |.. .... .|. |.      |... |.| |......||| 
.dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 765-1000 4.9e-62 204.4 In-house 4-244 (250) alignment 
Range on Protein: 765-1000
Range on HMM: 4-244/250.0
GRTPDNQPKNRYGNNLPLQRNRVILDSPD----QDYINASQMKGVHC--TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDKSCAQYWPDADSA
.. |.|. |||| . ..|.  ||.| . .     |||||| ..| .   .|..|| ||..|. ||| ||.  | .|||||.. ....| . ||||   . 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

QFGSYSVATLSTSSDGDMTTRQMKVTRNSNASH-TVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQ
..|.  |  ||.   .|.|.|..|......|.. .| |..|  ||  |  ..  |.. ..|.. |..| .. ..  ..|.| .| ||.| |..    . .
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPev..atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
. . . ||.|. .|.||.||.. |...| | ||| .| ..| .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0042113 (Phosphotyrosine protein) phosphatases II 765-998 1.8e-56 186.6 In-house 4-243 (245) alignment 
Range on Protein: 765-998
Range on HMM: 4-243/245.0
GRTPDNQPKNRYGNNLPLQRNRVILDSPD----QDYINASQMKGV--HCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQYWPDADS
.. | |..|||| . ||. ..||.| ...     |||||| ..|     .|  || ||| || ||| |.   . .|||||..   ...  ||||||. .|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

AQFGSYSVATLSTSSDGDMTTRQMKVTR-NSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIA
 ..| ..| .||. ...|.|.|...||.  .. |..|..|....|| ||       ..|......|..  .....  .||||  | ||||.|..|  .. 
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdl..lellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

QIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|. .   |.....|| ||  |.. |||.. | |.|....|.|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 765-998 6.1e-55 181.7 In-house 5-242 (243) alignment 
Range on Protein: 765-998
Range on HMM: 5-242/243.0
GRTPDNQPKNRYGNNLPLQRNRVILdsPDQDYINASQMKGVHcTFMTTQMPLPTTVSD----FWSMVVGSKPSTIVMLNDKS-QNDKSCAQYWPdaDSAQ
.. | |..|||| . ||. ..||.|  .. |||||. ....  ..  ||.||| || |    || |.   . ..||||..    . . ||||||  .. .
allpenlsknrysdilpydhsrvkl..egsdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevt

FGSYSVATLSTSSDGDMTTRQMKVTR--NSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNN-------KKEFSILVHCLSGAGRTGVFCT
.| ..| .||... .|.| | .....   .. ...|..|....|| ||  .     .|......|..  ..       ...  .||||  | ||||....
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPds..pedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

AMECIAQIaegnSVDIFQTVKILRADRMQ-FVQTEEEYAFVYDVIREYL
|  .. ..    .||....|| ||. |..  |||.. | |.|....|.|
aylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPRK_pd Subfamily PTPRK 766-996 2.5e-59 195.7 In-house 39-275 (314) alignment 
Range on Protein: 766-996
Range on HMM: 39-275/314.0
RTPDNQPKNRYGNNLPLQRNRVILDSPDQD----YINASQMKGVHC--TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQND-KSCAQYWPDADSA
.  .|. |||.|. |.  | ||.| . | |    ||||. . . .    |. || ||. || ||| .|   . ..||||..  ..    | .|||.  . 
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

qFGSYSVATLSTSSDGDMTTRQMKVTR---NSNASHTVTQYQFHGWPKHgsDQQLGARSLIKLIRAVKSSTNNkKEFSILVHCLSGAGRTGVFCTAMECI
 .|   |  ..|. . .. .| ..|..   . .. ..| |.|| |||.|  |    |..|.||.| ||.|... ..  |.|||..||||||.|..    .
.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

AQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
  | . . ||.|..|| ||. .. .|.||| | |.|||| |
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 766-997 2.8e-50 166.1 In-house 45-278 (315) alignment 
Range on Protein: 766-997
Range on HMM: 45-278/315.0
RTPDNQPKNRYGNNLPLQRNRVIL----DSPDQDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDKSCAQ-YWPDAdSA
.   |. |||| | ..  . || |      |. ||.||. ..|      ....| |....| ||| .|   . ..||||..  ...|. |. ||||    
kkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kv

QFGSYSVATLSTSSDGDMTTRQMKVTRNSNAsHTVTQYQFHGWPKHGSdqQLGARSLIKLIRAVKSSTNNKKeFSILVHCLSGAGRTGVFCTAMECIAQI
 .| ..|.  |     ..| | . |. ..|  ..| |...  ||. |      . .|..||| ||   .|.   .|.||| .| |||| |.|    . |.
iyGkitvtrkseevnteytvrtlsvvfgdni.revvqlhytswpdmgv..pkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqa

AEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
   | .|... .. .|. |.. ||. |.| |.||.. | 
eaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 766-998 1.1e-45 151.3 In-house 21-256 (284) alignment 
Range on Protein: 766-998
Range on HMM: 21-256/284.0
RTPDNQPKNRYGNNLPLQRNRVILDSPD----QDYINASQMKGVHC--TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNdksqnDKSCAQYWPDADSAQ
  ..|. |||.|. |.  .|.| |.  .     |||||| ..|      ...|| ||. |. ||| |.  .. ||||.|      .. |.||||     .
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplkivik

FGSYSVATLSTSSDGDMTTRQMKVTR--NSNASHTVTQYQFHGWPKHGSDQ-QLGARSLIKLIRAVKSSTNNKKefSILVHCLSGAGRTGVFCTAMECIA
 . . |   | .   ... |......  . .   ...|. | |||..|  .       |.| .| ..|  |...  .|.||| .|.|||||. .    . 
eerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhra..nivvhcsagvgrtgvyivldvlld

QIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE-YL
.. | . ||....|. || .| ..||   .| |.|  . | .|
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_PTPRA_pd Subfamily PTPRA 767-999 7.8e-55 181.0 In-house 55-297 (330) alignment 
Range on Protein: 767-999
Range on HMM: 55-297/330.0
TPDNQPKNRYGNNLPLQRNRVILD----SPDQDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLND-KSQNDKSCAQYWPDADSAQ
  .|. |||. | || . .||||      .. |||||| ..| .   .|...| |.  || ||| |.   | .||||| . | .... |||||||  .  
keenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt

FGSYSVATLSTSSDGDMTTRQMKVT-----RNSNASHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNKKEfSILVHCLSGAGRTGVFCTAMEC
.|   |.   .    |.| |.. |.     .. ..|  |.|. |..||. |   .  .. ..||...||.  ... . .| ||| .|.|||| |..    
yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe..piGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldav

IAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY-LH
....   . ||.|..|| ||. | | |||.| | |.| |..|| |.
lervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 767-999 3.4e-48 159.1 In-house 25-269 (274) alignment 
Range on Protein: 767-999
Range on HMM: 25-269/274.0
TPDNQPKNRYGNNLPLQRNRVIL-----DSPDQDYINASQMKGVH---CTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLND-KSQNDKSCAQYWPDADS
 . .| |||| . || .. ||.|     ...|..||||  .|| .    ... || |||.||.||| |.   . . |||| . | .| . ||.|.||| .
vfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

A----QFGSYSVATLSTSSDGDMTTRQMKVTRNSNaSHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNKKEF--SILVHCLSGAGRTGVFCTA
.    ..|  .. . .. .  | . |.. .   .. ...|. | .  || | | ..  |..|..|.. |..| .....   ...||| .| ||||.| ..
yeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

MECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
  .. |. | . ||....|  || ||   |||.| | ... .. .||.
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 767-1000 5.6e-22 72.8 In-house 45-289 (305) alignment 
Range on Protein: 767-1000
Range on HMM: 45-289/305.0
TPDNQPKNRYGNNLPLQRNRVILDSP-DQDYINASQMKG--VHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVML-NDKSQNDKSCAQYWPDADS--AQF
  ... |||| .   |..||| |..|   .|| |  .        |. || ||  | .||| | .  |  .| || | . .  | |..|..  |    .|
eaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

-----------GSYSVATLSTSSDGDMTTRQMKVTRNSNASHTVTQYQFHGWPKHGSDQqlGARSLIKLIRAVKSSTNnkkefSILVHCLSGAGRTGVFC
            | .   . .... ..|  .. .    . .. ||.| .  ||  |        ....|.   ..|        | ||| .| ||||   
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa..adlailellekarpskg.....pivvhcsagigrtgsvv

TAMECIAQIAEGNSVDIFQ-TVKILRADRMQFVQTEEEYAFVYDVIREYLHT
     . |. .|. ..  .  .. .| .| . .||...| ||..|| .|.. 
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_CG42327_pd Subfamily CG42327 767-924 5e-17 56.5 In-house 25-192 (319) alignment 
Range on Protein: 767-924
Range on HMM: 25-192/319.0
TPDNQPKNRYGNNLPLQRNRVILDS----PDQDYINASQMKGV---HCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQND-KSCAQYWPDADS-
 .  ..|.|. | .||   ||.|..    . . |..|| ..|    .. ....|..|  . |||| .|   .  .|| | | |..  | ||.|.|  .. 
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

---AQFGSYSVaTLSTSSDGDMTTRQMKVTRN--SNASHTVTQYQFhGWPKHGSDQQlgARSLIKLIRAVKS
     .| . | ||     .|       . ..   . |  .| | .  |.. .   .   ..|| ..  |.|
dntslyGdilv.tlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPae..eaaliamllevrs
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 769-995 9.9e-39 127.9 In-house 2-236 (237) alignment 
Range on Protein: 769-995
Range on HMM: 2-236/237.0
DNQPKNRYGNNLPLQRNRVILDSP--DQDYINASQMKGVHC---TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDK-SQNDKSCAQYWPDADS-AQFG
.|. ||||||    . .||.|  .  . |||||. .||.     .....| || ..  ||| ||   | | ||||     .|.. | .|||..|  | .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SYSVATLSTSSDGDMTTRQMKVTRNSNA--SHTVTQYQFHGWPKHGSDQQLGArsLIKLIRA-VKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQI
 ..|.        | | | . .... .      . ||||  ||..|  ||  |  |... .  .. |    .    ..|| .| ||||.|      . | 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

AEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
 | . |||.. |. .  ||   .||...| |....| 
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
Y_phosphatase Protein-tyrosine phosphatase 770-994 8.3e-64 210.6 Pfam-A 1-233 (235) alignment 
Range on Protein: 770-994
Range on HMM: 1-233/235.0
NQPKNRYGNNLPLQRNRVIL-DSPD-QDYINASQMKGV--HCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQ-NDKSCAQYWP--DADSAQFGS
|. |||| . || ...|| | .|.. .|||||. .||   . .|. ||.||. |..||| ||.  | ..||||..  . ... ||||||  . .| ..|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVATL-STS-SDGDMTTRQMKVTRNSNA--SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTnNKKEFSILVHCLSGAGRTGVFCTAMECIAQI
..| .  ...  . ..|.|..... . .   ...|.|.....||.||  ..  ..||..|||.|..|. ..|. ...|||  |.||||.|.... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
 ....||..|.|| ||. |.. ||..|.|.|.|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 770-994 8.3e-64 210.6 In-house 1-233 (235) alignment 
Range on Protein: 770-994
Range on HMM: 1-233/235.0
NQPKNRYGNNLPLQRNRVIL-DSPD-QDYINASQMKGV--HCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQ-NDKSCAQYWP--DADSAQFGS
|. |||| . || ...|| | .|.. .|||||. .||   . .|. ||.||. |..||| ||.  | ..||||..  . ... ||||||  . .| ..|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVATL-STS-SDGDMTTRQMKVTRNSNA--SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTnNKKEFSILVHCLSGAGRTGVFCTAMECIAQI
..| .  ...  . ..|.|..... . .   ...|.|.....||.||  ..  ..||..|||.|..|. ..|. ...|||  |.||||.|.... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
 ....||..|.|| ||. |.. ||..|.|.|.|..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 770-1001 1.9e-45 150.0 In-house 20-267 (270) alignment 
Range on Protein: 770-1001
Range on HMM: 20-267/270.0
NQPKNRYGNNLPLQRNRVILDS----PDQDYINASQMK---GVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLND-KSQNDKSCAQYWPDADSA---
..  ||| . ||  . ||.|..    . . ||||  ..   | ........ |||||...|| |.. .| ..|||. . . .. | |..|||        
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-QFGSYSVATLSTSSDGDMTTRQMKVTrNSNASHTVTQYQFHGWPKHGSDQQLG----ARSLIKLIRAVKSSTNNKKE-FSILVHCLSGAGRTGVFCTAM
 ..|  .|..||.. .    ....... ..  .. .. .... || ||  .. .    ...|.|..|||. |......   .||||  | ||||.. .  
ledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

ECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
 ..  . | ..||. . .. || |||..||. |.|.|.| ...|| .. 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
0041856 (Phosphotyrosine protein) phosphatases II 770-1004 9.1e-37 121.8 In-house 1-177 (182) alignment 
Range on Protein: 770-1004
Range on HMM: 1-177/182.0
NQPKNRYGNNLPLQRNRvildspDQDYINASQMKGVHCT--FMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNdksqndksCAQYWPdadsaqfgsysvat
|..|||| . ||  ..|      | |||||. . | . .  |  || ||. || ||. |. . . .|||.|.        . .|||              
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..............

lstssdgdmttrqmkvtrnSNASHTVTQYQFHGWPKHGSDQqlgARSLIKLIRAVKSstnnkKEFSILVHCLSGAGRTGVFCTAMECIAQiaegnSVDIF
                   ..  ....||....|| ||       ..|...|..|..     ..  .||||  | ||||... |  .. .     .|...
...................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

QTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYE
..|| .|  |.. |.|.. | |......|.|.  ...
eavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 770-993 5.3e-31 102.6 In-house 7-235 (239) alignment 
Range on Protein: 770-993
Range on HMM: 7-235/239.0
NQPKNRYGNNLPLQRNRVILD----SPDQDYINASQMK---GVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQ-NDKSCAQYWPDADSaQFG
|. |||| | .  ...||.|.     |  |||||| ..   |   ....||  . ..  ||| |.   .   ||||    .   | | |||||. | .. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

SYSVATLSTSSDGDMTTRQMKVTRNSNA-SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAV-KSSTNNKKEFsiLVHCLSGAGRTGVFCTAMECIAQIA
   |.   |    |   | . ...  ..  . | ||.|  || .|  |   | ... | | . | |    . .  ..|| .| |||| |      . |  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpw..vihcsagvgrtgaflvidamlrqak

EGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
. ..||||. || .| || ..||| |.| |..  
kqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 770-992 5.6e-31 102.5 In-house 8-235 (239) alignment 
Range on Protein: 770-992
Range on HMM: 8-235/239.0
NQPKNRYGNNLPLQRNRVILD----SPDQDYINASQMK---GVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQ-NDKSCAQYWPDADSaQFG
|. |||| | .  ...||.|.     |  |||||| ..   |   ....||  . ..  ||| |.   .   ||||    .   | | |||||. | .. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

SYSVATLSTSSDGDMTTRQMKVTRNSNA-SHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAV-KSSTNNKKEFsiLVHCLSGAGRTGVFCTAMECIAQIA
   |.   |    |   | . ...  ..  . | ||.|  || .|  |   | ... | | . | |    . .  ..|| .| |||| |      . |  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpw..vihcsagvgrtgaflvidamlrqak

EGNSVDIFQTVKILRADRMQFVQTEEEYAFVYD
. ..||||. || .| || ..||| |.| |.. 
kqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 770-1002 2.3e-30 100.6 In-house 35-274 (285) alignment 
Range on Protein: 770-1002
Range on HMM: 35-274/285.0
NQPKNRYGNNLPLQRNRVILDSPDQDYINASQMKG---VHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQN-DKSCAQYWPDA--DSAQFGSY
|   ||| .   ..  ||.|   |.||| || |.     . |..||| ||| |.|||| |.   | . ..||    .   . || |.|.   .  .|| |
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

SVATLSTSSDGDMTT--RQMKVTRNSNASHT---VTQYQFHGWPKHGSDQqlGARSLIKLIRAVKSStnNKKEFSILVHCLSGAGRTGVFCTAMECIAQI
 ..      .    |    . |.   .||     . . |   || . . .   || .|.| . ||    | ||  | ||| .| |||  |     .  .|
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlape..darpmielykwvkkv..npkekpicvhcsagvgrtatfvgidyatiri

AEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 |   ..... |. .|| |.| ||.  .. |.| |. ||.  | 
menpniemldivremramrfqavqshmqflflyvvlmeyfigeg
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 770-1005 3.8e-21 70.4 In-house 43-278 (288) alignment 
Range on Protein: 770-1005
Range on HMM: 43-278/288.0
NQPKNRYGNNLPLQRNRVILDsPDQDYINASQMKGVHC---TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQYWPDA--DSAQFGSY
|  ..|| |       || |.  | |.  |...   .     .. .| || .|.  .| |.. |    ||||..  .  |   |.|.|    ..|..| .
nptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

SVATLSTSSDGDMTT--RQMKVTRNSNASHTVTQYQFHGWPKHGSDQQLgaRSLIKLIRAVKSSTNnkkefSILVHCLSGAGRTGVFCTAMECIAQIAEG
   .    .| | .     ...... . .  | .  .. |...|  ..    | ..|.  .|| ..      |.||.  |.|||| .   .  . ..   
ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPeny..lsplrllevlkslqk.....PivvhssaGvGrtgtlililialeslrld

NSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQ
. . | . .. ||..|.. .|||  | .|. .. |.|    |..
dflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 770-1000 3.7e-19 63.3 In-house 51-287 (302) alignment 
Range on Protein: 770-1000
Range on HMM: 51-287/302.0
NQPKNRYGNNLPLQRNRVILDSPDQDYINASQMKGVHC--TFMTTQMPLPTTV---SDFWSMVVGSKPSTIVMLNDKSQNDKSCAQYWP--DADSAQFGS
|  ||.  .   |. |.|.|.   ..|.|||...  ..  . . .|.|  ...    .|| ||   |  ..|.|  . . .|.  ...|    |  ..|.
nlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygk

YSVATLSTSSDGDMTTR-QMKVTRNS-NASHTVTQYQFHGWPKHGSDQQLGarSLIKLIRAVkSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAE
  | .   ..  ...||  . |  .    |  .. | .. |...   .. .  .||| .  |    . | . ....    |||| |.| |..  . .. .
mfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya..eliktaakv.fakkikadentvivSknGaGRagafltlavaveklqk

GNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
|. . | ..|| .|..| . |.. . |...| ..  |. .
gkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 770-994 2.7e-15 50.7 In-house 52-286 (310) alignment 
Range on Protein: 770-994
Range on HMM: 52-286/310.0
NQPKNRYGNNLPLQRNRVIL---DSPDQDYINASQMKG--VHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQYWPDADS-AQFGS
.  |||| . . |.  || |    |  .||| |  .|   .  ||. .| ||  |. ||| |.   .  .|..|   ... .  |  |||       .| 
ymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygc

YSVATLSTSSDGdMTTRQMKVTRN----------SN-ASHTVTQYQFHGWPKHGSDQQLGARSLIKLIRAVKSStnnkkefSILVHCLSGAGRTGVFCTA
  |. || ||.  .   .. ||            .|     |.  ..  ||  |  ..       .|.  |.           .||| .| .|..| .. 
irvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg.......pcvvhcsagkdrlyvvval

MECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
   | .. .|. ||. . .  |. .|.. .||| .| ..  | 
klkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 771-1006 8.8e-19 62.3 In-house 44-284 (312) alignment 
Range on Protein: 771-1006
Range on HMM: 44-284/312.0
QPKNRYGNNLPLQRNRVILDSPDQDYINASQMKGVH--CTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQ-NDKSCAQYWPDADS-AQFGSYSVA
.  ||| |    .| |  |   .. || |  .| .     |..|| ||  |.. || ...    ..|..|    .   . ||.|  |  .  ..  . | 
kdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvy

-------TLSTSSDGDMTTRQMKVTRNS-NASHTVTQYQFHGWPKHGSDQQLgaRSLIKLIRAVKsstNNKKefSILVHCLSGAGRTGVFCTAMECIAQI
        .   |   .| | .||  ..      . .||.  || ||  .     .  .|. |||   ..||   .. || .| |||| ..     || .
teycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdsc..dtalrllsavk...kdkk..pviahcsagvgrtgtlaliesmiaal

AEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQR
      .. ..  .|| || . |..  .| ..  .. |.|...   .|
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 772-859 1.7e-13 45.0 In-house 49-157 (350) alignment 
Range on Protein: 772-859
Range on HMM: 49-157/350.0
PKNRYGNNLPLQRNRVILD----S--------PDQDYINASQMKGV------HCTF--MTTQMPLPTTVSDFWSMVVGSKPSTIVMLND-KSQNDKSCAQ
 |||| | ||  ..||.|     |          .|||||. .|           |  . || ||| || ||. ...  |   |..|..   .| . | .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPDADSAQ
||.. .  .
YWqegsydd
subfamily_eak_pd Subfamily eak 779-1006 2e-18 60.9 In-house 60-313 (332) alignment 
Range on Protein: 779-1006
Range on HMM: 60-313/332.0
NLPLQRNRVILDSPD---QDYINASQMK--GVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQND-KSCAQYWPDAD--SAQFGSYSVATLST
 .| .|. | | |     . ||||| ..   |   .. | ..  . |  || ||.  |  .||.| .. ... .   .|.||      .|| . | . . 
ivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef

SSDGDMTTRQMKVtRNSNASHTVTQYQFHGWPKHGS------------DQQLGARSLIKLIRAVKSSTNNKK-----EFSILVHCLSGAGRTGVFCTAME
   . . ||.... .  | .| |  |...|| .                .. |.  ||    |. ||| .|       |. .. .  |. |.|||     
vkrniletrllel.skGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidl

CIAQIA--EGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQR
 |  |     |.  . . .   .  |.  | .. ...|.|... .|| . | . |
lirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlr
0044763 (Phosphotyrosine protein) phosphatases II 781-999 1.8e-19 65.5 In-house 1-172 (178) alignment 
Range on Protein: 781-999
Range on HMM: 1-172/178.0
PLQRNRVILDSPDQ----DYINASQMKGVhcTFMTTQMPlpttvSDFWSMVVGSKPSTIVMLNDKSQND-KSCAQYWPDADSaqfgsysvatlstssdgd
|| |.||.|... .    ||||||.. .    ..... |     .|.. ..   . ..||.|..   .   .| .|||.  .                  
pldrtrvllsnleglersdyinaseilpg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

mttrqmkvtrnsnashtvTQYQFHGWPKHGSDQ-QLGARSLIKLIRAVKSstnnKKEFSILVHCLSGAGRTGVFCTAMECIAQiaegnSVDIFQTVKILR
                   ||.. ..| ||  .     . ....|... .    .|.  .||||  | ||.|... |  .. .     ...... .. .|
..................iqylhipipDhgvpdllehflefvefieeald....ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvr

ADRMqFVQTEEEYAFVYDVIREYLH
. |. .|.... . ..|.. ...| 
erRp.ivpnpgqlrqLyefelrllk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 781-906 6.6e-09 30.2 In-house 4-126 (130) alignment 
Range on Protein: 781-906
Range on HMM: 4-126/130.0
PLQRNRVIldspDQDYINASQM--KGVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDkscaQYWPDADSAQFGSYSVATLSTSSDGD--M
. . .|.     ...||||| .   |    .. || ||  |  ||| |..      .|.|    ..|    .||||..  ..    .   .|  |.   .
efevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivtltdrdefkni

TTRQMKVTRNSNASH-TVTQYQFHGWPKHGS
 . .... .. | || ..| .|   ||  |.
kasnleiesdlneshqaltmfqisnwpsdgt
0046846 (Phosphotyrosine protein) phosphatases II 785-998 6.5e-29 96.3 In-house 3-173 (176) alignment 
Range on Protein: 785-998
Range on HMM: 3-173/176.0
NRVILDSPDQDYINASQMKGvhCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKS-QNDKSCAQYWPDADSAQFgsysvatlstssdgdmttrqmkv
 |.. . .| |||||. . |  . . .|| ||| |. ||. |.   . ...|.|..    .  .|..|||.  ....                       
lrllgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

trnsnashtvtQYQFHGWPKHGSDQQlgaRSLIKLIRAVKSSTNNKkeFSILVHCLSGAGRTGVFCTAMeciaQIAEGNSVDIFQTVKILRADRM-QFVQ
           ||....|| ||  .    . |..|......  ...    .||||  | ||||... |      .  .. ........ .|. |. . ||
...........qylhlpwpDhgvpdl...elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

TEEEYAFVYDVIREYL
|.| | |.|......|
tpeQyrflyefellll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 785-995 5.7e-22 73.2 In-house 33-256 (290) alignment 
Range on Protein: 785-995
Range on HMM: 33-256/290.0
NRVILDSP----DQDYINASQMKGVH-CTFMTTQMPLPT-------TVSDFWSMVVGSKPSTIVMLNDKSQNDK-----SCAQYWPDAD--SAQFGSYSV
.||.|        .||| |....  .   .. || |.         |. .|| |.   |   .||| . .....     .||.| |..   . .|.  .|
trvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltv

ATLSTSSDGDMTTRQMKVTRNSNASHTVTQYQFHGWPKHgsDQQLGARSLIKLIRAVKsstnnKKEFSILVHCLSGAGRTGVFCTAMECIAQIA-EGNSV
   |   . |. ||.. |. . .  .||| ....|| |     |   ..|..||. ||     ...  ..|||  |  |  .. .       ||   .||
kCkskekeddvetRelvvkfddeeeftvtHsllkgWnkl..nvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv

DIFQTVKILRADRMQFVQTEEEYAFVYDVIR
 . . .| ||  | . .....|.|||  .| 
kledvlkalrkqralaitsalelafvdagiv
0043147 (Phosphotyrosine protein) phosphatases II 792-992 1.2e-26 88.9 In-house 3-155 (172) alignment 
Range on Protein: 792-992
Range on HMM: 3-155/172.0
PDQDYINASQMKGVHCT--FMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKsqndkscaqywpdadsaqfgsysvatlstssdgdmttrqmkVTRNSNA
.. |||||| .......  |  || ||. |..||| |.   . ..||.|..                                          ..  .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpell

SHTVTQYQFHGWPKHGSDqqlGARSLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIaqiaegNSVDIFQTVKILRADRMQFVQTEEEYAF
.... ||....|| ||      .. |..... ...  .....  .||||  | ||||... |  ..       .......|. .|. |.. ||... | |
erlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

VYD
.|.
lyy
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 792-847 1.7e-07 25.1 In-house 68-124 (347) alignment 
Range on Protein: 792-847
Range on HMM: 68-124/347.0
PDQDYINASQMKG--VHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKsQNDKS
. . |||||..|    .  .. || ||| || ||| ||   | . .| . .  ..|..
dvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep.ikdea
0051082 (Phosphotyrosine protein) phosphatases II 793-994 1.9e-25 84.6 In-house 2-149 (151) alignment 
Range on Protein: 793-994
Range on HMM: 2-149/151.0
DQDYINASQMKGVhctFMTTQMPLPttvsDFWSMVVGSKPSTIVMLNDKSQNDkSCAQYWPDADsaqfgsysvatlstssdgdmttrqmkvtrnsnasHT
 .||||.|.. |    .  ...||.    ||. ..   . .|||.|...  ..  |..|.|...                                  ..
lsdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg..................................ie

VTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSstnnKKEFSILVHCLSGAGRTGVFCTAMECIAQiaegnsVDIFQTVKILRADRMQFVQTEEEYAFVYD
|.......|| .| ..     ......... .    ||.  .|||| .| ||||... .. .. .      |....... .|. |. .||..... |.. 
vlhipildwpdpglpls..fdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

VI
..
al
0051429 (Phosphotyrosine protein) phosphatases II 794-1000 2.9e-36 120.9 In-house 4-227 (272) alignment 
Range on Protein: 794-1000
Range on HMM: 4-227/272.0
QDYINASQMKGVhCT------FMTTQMPLPTTVSDFWSMvVGSKPSTIVMLNDKSQND-KSCAQYWP------------DADSAQFGSYSVATLSTSSDG
..||||. ..|  .       .  ...||| |. ||| .    . .|||.| . .  .   | .|||            .| .  .| ..| .||..   
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DMTTRQMKVTRN--SNASHTVTQYQFHGWPKHGSDQQLgARSLIKLIRAvksstnnkkEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVD-------
|.. | . .|.    .....|.......|| ||  |.   ..|..|...         .  .|||| .| .|||... .  ..... .   ||       
dyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 ....|. ||| |...||||| |.|.|....|.| .
yleeaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 794-992 2.5e-29 97.6 In-house 2-164 (174) alignment 
Range on Protein: 794-992
Range on HMM: 2-164/174.0
QDYINASQMKGVHCT--FMTTQMPLPttvsdFWSMVVGSKPSTIVMLNDKSQND-KSCAQYWPDadsaqfgsysvatlstssdgdmttrqmkvtRNSNAS
 |||||| ......|  .  .| ||.     || |.   . .|.|||..  ...   | .|||.                              . .  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

HTVTQYQFHGWPKHGSDQQLGarsLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAeGNSVDIFQTVKILRADRMQFVQTEEEYAFV
... ||.. .|| ||         |......|..  .....  .||||  | ||||... |. .. ..   . ||....|. ||  |.. |||.. | |.
rlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YD
|.
yy
subfamily_egg_pd Subfamily egg 794-996 3.3e-19 63.7 In-house 68-268 (307) alignment 
Range on Protein: 794-996
Range on HMM: 68-268/307.0
QDYINASQMKG--VHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNdKSCAQYWPDA--DSAQF--GSYSVATLSTSSDGD--MTTRQMKVTR
.|.| | ..||  .  .|. .| ||  || ||| ||   .   ||||. . .. . |  ||| |  ||...  ||. . .|   |  |  ..  ..|.  
ddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvG

NSNASHTVTQYQFHgWpKHGSDqqlgARSLIKLIRAVKSSTNnkkefSILVHCLSGAGRTGVFCTAMECIAQIAEGNS--VDIFQTVKILRADRMQFVQT
  .    .  .|   . .. ||      | ....| ..  ..      ..|..  |  ..... ..   . ..  |      . ..|. ||  |   |..
gddeerflehwqgd.v.nnssd....vysplrvlrklrnlsk.....pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsves

EEEYAFVYDVIRE
   | ||| ..  
vllylfvyrlvlf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 794-855 3.7e-08 27.1 In-house 90-156 (349) alignment 
Range on Protein: 794-855
Range on HMM: 90-156/349.0
QDYINASQMK----GVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLN-DKSQNDKSCAQYWPDA
.|||||  .|     |.  ...||.|||.|| ||. ...  .   .. || || .. . | .|| . 
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 803-997 1.2e-23 78.3 In-house 86-285 (301) alignment 
Range on Protein: 803-997
Range on HMM: 86-285/301.0
KGVHCTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQ-NDKSCAQYWPDADS--AQFGSYSVATLSTSS--DGDMTTRQMKVTRNS--NASHTVTQ
.|    |..|| ||. |  ||| |.|  .  .||||  | . . . |..| |   |   . | ... . .. .  . ... |...|.  .   |..||| 
sGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvth

YQFHGWPKHGSDQqlGARSLIKLIRAVKSSTNnkkefSILVHCLSGAGRTGVFCtAMECIAQ-IAEGNSVDIFQTVKILRADRMQFVQTEEEYAF-----
||.. |...|  .  .   | .|.  || | .      |.||| .| ||.  |  . |..|. .   . ... ...| || .| . |||..   .     
yqysewtdrgvPk..shaelfdlmelvkksek.....PivvhcsaGiGrsvafi.gteylareveadptieltealkhlrehrwngvqtnsqlywmtlGt

VYDVIREY
|| .|.||
vyrlikey
0049260 (Phosphotyrosine protein) phosphatases II 807-992 4.8e-24 80.2 In-house 9-144 (152) alignment 
Range on Protein: 807-992
Range on HMM: 9-144/152.0
CTFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQYWpdadsaqfgsysvatlstssdgdmttrqmkvtrnsnashtvtQYQFHGWPKHG
  |. || |.| |..||| |.   . .|||||.. . ..|  |.||.                                          ||... || ||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDhg

SDQQLGARSLIKLIRAVKsstNNKKEFSILVHCLSGAGRTGVFCTAMECIaqiaegNSVDIFQTVKILRADRMQFVQTEEEYAFVYD
  .       . |.       . .|.  .||||  | ||||... |  ..      . |.....|. .|. |.. |.... . |.|.
vpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 808-995 1.4e-31 104.3 In-house 237-435 (440) alignment 
Range on Protein: 808-995
Range on HMM: 237-435/440.0
TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDksQNDKSCAQYWP-DADSAQFGSYSVATLSTSSDGDMTTRQMKVTRnSNASHTVTQYQFHGWPKHG-
.|..||||| .|| ||| .|   . |||.|||.   |||.|. ||| .. |  || ..|    .     .  | ...    .  | . |..   ||    
afiatqmpldstvldfwrlvhdyristiimlnq..lndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelky.keevheirqfevqtwptwiq

SD----QQLGARSLIKLI---RA--VKSSTNNKK---EFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
||    |.    ....|.   |   .. ||.. .      ||||||||   .||||| |.|. |. .  ..|.|| ...||  | .|| |  .| ..| .
sdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykl

IR
. 
lt
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 808-993 4.8e-23 76.4 In-house 5-198 (198) alignment 
Range on Protein: 808-993
Range on HMM: 5-198/198.0
TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQYWPDADS--AQFGSYSVATLSTSSDGDMTTRQMKVTRNSNAS---HTVTQYQFHGW
 ...|| ||  |..||| ||  .    |||.||  .| .   . ||| ..|  ...|| ||.| . ..  |.|   . .| |. |      ...|||  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHGSDQQLGARSLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEG--NSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 .. . .      ..   | |    ...|.  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |.|.|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 808-993 5.1e-23 76.3 In-house 6-199 (199) alignment 
Range on Protein: 808-993
Range on HMM: 6-199/199.0
TFMTTQMPLPTTVSDFWSMVVGSKPSTIVMLNDKSQNDK-SCAQYWPDADS--AQFGSYSVATLSTSSDGDMTTRQMKVTRNSNAS---HTVTQYQFHGW
 ...|| ||  |..||| ||  .    |||.||  .| .   . ||| ..|  ...|| ||.| . ..  |.|   . .| |. |      ...|||  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHGSDQQLGARSLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEG--NSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 .. . .      ..   | |    ...|.  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | |.|.|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 812-998 3.6e-11 36.3 In-house 123-309 (346) alignment 
Range on Protein: 812-998
Range on HMM: 123-309/346.0
TQMPLPTTVSDFWSMVVGSKPSTI-VMLNDKSQNDKSCAQYWPDADSAQF-GSYSVATLSTSSDGDMTTRQMKVTRNSNASHTVTQYQFHGWPKHgSDQQ
 ||   . | ||| |.   .   . .|. |   .. . . .  .    |. |   .    .   ||     ..|  . |.   . | . |   ||  .| 
pqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkh.lqqp

LGARSLIKLIRAVKSSTnNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  .  .||.|   .|   . ..  . |  | |.||.  |  |.  | |. .|   .|.. .| .. .|   |..  .|| .| .. .|.
pktlpiikmihqflsek.qvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 814-990 2.7e-14 47.3 In-house 98-280 (302) alignment 
Range on Protein: 814-990
Range on HMM: 98-280/302.0
MPLPTTVSDFWSMVVGSKPSTIVMLND-KSQNDKSCAQYWPDA--DSAQFGSYSVATLSTSSDGDMTTRQMKV----------TRNSNASHTVTQYQFHG
.|   |.  .|...   . . .| | . . ...| ||.|. |   .  .|| |.| |.|   | .  | . ..           ....  .||   .| .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPKHGSDQQlgARSLIKLIRAVKSStnnKKefSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFV
||.||. ..  | . .....  .|    ||  ..||||  | |||| . .    |   .. .  |. . |. .|. |   ||.|.   ..
wpdhGapke..aytaldilkfcesy...kk..nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 817-992 8.1e-17 56.0 In-house 44-221 (263) alignment 
Range on Protein: 817-992
Range on HMM: 44-221/263.0
PTTVSDFWSMVVGSKPSTIVMLNDKSQN-DKSCAQYWPDADSAQFGSYSVATLSTSSDGDMTTRQMKVTR---NSNASHTVTQYQFHGWPKHGSDQQlgA
  |.  |....| .|....||| |   .  . | .|.|     .     |.  .| .  |.  .  ...    .    |||..|.. ||...   ..  |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpel..a

RSLIKLIRAVKSStnnKkefSILVHCLSGAGRTGVFCTAmECIAQ-----I--AEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYD
|. ........ |   |   |. ||| .| ||.  |  | | . |     .  ..   .|  . .. ||  | . ..|    ||   
reilnilkvarns...k...slvvhcstGiGrsaafsva.ElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 819-1008 3.9e-19 63.7 In-house 40-231 (255) alignment 
Range on Protein: 819-1008
Range on HMM: 40-231/255.0
TVSDFWSMVVGSKPSTIVMLNDKSQ-NDKSCAQYWPDAD--SAQFGSYSVATLSTSSDGDMTTRQMKVTRN-SNASHTVTQYQFHGWPKHGSDQQlgARS
||  |. ..| .|....||| |  . . . | .|.|       ..   .|.|  .|.|  . |...  |       |||. |...||... . ..  || 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel..are

LIKLIRAVKSStnnKkefSILVHCLSGAGRTGVFCTAmECIAQ-----I--AEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQRP
. .....|. |   |   |..||| .| ||.  |  | | . |     .  .|   .|  . .. ||  | . ..|  . ||   .. .... ..  .  
ilnilkvvrds...k...svvvhCstGiGrsaafvla.elvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleak

Y
|
y
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 844-994 1e-06 22.4 In-house 146-298 (332) alignment 
Range on Protein: 844-994
Range on HMM: 146-298/332.0
NDKSCAQYWPDADSA-QFGSYSVATLSTSSDGDMTTRQMKVTRNSNASHTVTqYQFHGWPKHG--SDQQLGARSLIKLIRAVKSSTNNKKEFSILVHCLS
. | | ..||.  |  .| . |. .    |.  | | .. || . .  .||   .|. |       .  |  |. |||     |         |.. | .
kakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvl.mhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcat

GAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
|  .  ...|    ...|.|   | . .|.  .. .|.  ..|   |.   ...
gvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystaceml
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 864-1005 4.7e-95 313.3 In-house 251-392 (392) alignment 
Range on Protein: 864-1005
Range on HMM: 251-392/392.0
SVATLSTSSDGDMTTRQMKVTRNSNASHTVTQYQFHGWPKHGSDQQLGARSLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQIAEGNS
 ...||||||||....|.|..|...|||||||||||||||||||||.|||||.|||||||.|||.|||||||||||||||||||||||||||||||||.|
hlqdlstssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegds

VDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYEQ
||||||||||||||||||||||||||||||||||||||.|||
vdifqtvkilradrmqfvqteeeyafvydvireylhtekyeq
0048179 (Phosphotyrosine protein) phosphatases II 867-992 3.9e-15 51.3 In-house 35-139 (144) alignment 
Range on Protein: 867-992
Range on HMM: 35-139/144.0
TLSTSSDGDMTTRQmkvtrnsnashtVTQYQFHGWPKHGSDQQ-LGARSLIKLIRAVKSstnnkKEFSILVHCLSGAGRTGVFCTAMECIaqiaEGNsVD
.|... . .  .|.            ..||.. .|| ||  .     ......|... .     ..  .||||  | ||||....|  ..    . . ..
nlteeyepeflere............giqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgRtgtlvaaylmk....klg.ls

IFQTVKILRADRMQFVQTEEEYAFVYD
...... .|. |.. |.... . |...
leealalvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 879-1002 1e-56 187.1 In-house 161-280 (515) alignment 
Range on Protein: 879-1002
Range on HMM: 161-280/515.0
RQMKVTRNSNaSHTVTQYQFHGWPKHGSDQQlgARSLIKLIRAVKSSTNNKKeFSILVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRM
|...|..... |.||||..|..||..|....  ..||.|||..||..... . .....||..|.|||||........|.......||.|..|...|..|.
rkltvlkgdd.srtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrp

QFVQTEEEYAFVYDVIREYLHTEN
..|||.|.|||.|....|.|.  |
ylvqtqeqyafiygavledllwrn
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 882-998 1.1e-07 25.5 In-house 209-344 (349) alignment 
Range on Protein: 882-998
Range on HMM: 209-344/349.0
KVTRNSNASHTVTQYQFHGWPKHgsDQQLGARSLIKLIRaVKS----------STNNKKEFSILVHCLSGAGRTGVFCTAMECIA--QIAEGNSV-----
 .. ...  . . | |.  |.       |   |... .  ||.            ....  ..|||| .| |||||..|    ..  .  . .|.     
aillavekPyellqlqvknwldl..slllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklq

-----DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
      |. .| .||  |.. ||   .. ..|. . .|.
allkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
0048076 (Phosphotyrosine protein) phosphatases II 886-997 5e-16 54.1 In-house 40-142 (145) alignment 
Range on Protein: 886-997
Range on HMM: 40-142/145.0
NSNASHTVTQYQFHGWPKHGSDQQLgaRSLIKLIRAVKSSTNNKkeFSILVHCLSGAGRTGVFCTAMECIAqiaegNSVDIFQTVKILRADRMQFVQTEE
 .. .....||.. .|| ||  . |  . |.........  ...    .||||  | ||||... |. ..      ..|....... .|. |...|....
lellerlgiqylylpwpDhgvpdll..ellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpg

EYAFVYDVIREY
 . |.|....|.
qlrflyefelel
PTPc_DSPc_SM00012 892-995 1e-27 91.8 In-house 1-104 (105) alignment 
Range on Protein: 892-995
Range on HMM: 1-104/105.0
TVTQYQFHGWPKHGSDQQLgaRSLIKLIRAVKSSTNNKK-EFSILVHCLSGAGRTGVFCTAMECIAQIAEG-NSVDIFQTVKILRADRMQFVQTEEEYAF
||..|...|||.||  ..    |...|.||||...|... . ...|||  |.||||.|...  .. |. .. ..|||||.|| ||  |.. |||||.| |
tvkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

VYDVIR
.|... 
lyrall
subfamily_CG42327_pd Subfamily CG42327 910-997 6.1e-14 46.4 In-house 225-314 (319) alignment 
Range on Protein: 910-997
Range on HMM: 225-314/319.0
LGARSLIKLIRAVKSSTNN-KKEFSILVHCLSGAGRTGVFCTAMECIAQIAEG-NSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
 |. |  ..   . | . . ..   . |||  |.||||.  ..   | .. |  .|||| |.|  .| || . |.| | |.|.| |. ||
agstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_PTPDC1_pd Subfamily PTPDC1 910-993 3.3e-06 21.6 In-house 93-171 (182) alignment 
Range on Protein: 910-993
Range on HMM: 93-171/182.0
LGARSLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIAQiaegnSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
 |..|| ...  ||  .   .|  . ||| .| |||||  ...   |.     ...  ...|..|. | . .|| |   .| . 
ygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvkef
0038934 (Phosphotyrosine protein) phosphatases II 911-950 9.6e-06 20.9 In-house 95-134 (194) alignment 
Range on Protein: 911-950
Range on HMM: 95-134/194.0
GARSLIKLIRAVKSSTNNKKEFSILVHCLSGAGRTGVFCT
    | . ...|.  .|....  ..|||  | ||||... 
sleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 921-998 5.7e-10 33.4 In-house 252-344 (350) alignment 
Range on Protein: 921-998
Range on HMM: 252-344/350.0
AVKSSTNNKKEFSILVHCLSGAGRTGVFCTAMECIA------QIAE-GNSV--------DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  .|  .|..  .||||| .| ||||...|    .       .. .  . .         |...|..||  |.. ||. . . |.|. .. | 
faeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 935-998 3.4e-13 43.8 In-house 2-65 (69) alignment 
Range on Protein: 935-998
Range on HMM: 2-65/69.0
LVHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  | || |..| . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 936-998 2.8e-13 44.0 In-house 2-64 (69) alignment 
Range on Protein: 936-998
Range on HMM: 2-64/69.0
VHCLSGAGRTGVFCTAMECIAQIAEGNSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  |.|| |..| . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal