Gene SpurPTP-sf1-4 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP081_AA protein Get Run
SpurP081_AA_0-153 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 1-154 5.1e-43 142.9 In-house 149-301 (308) alignment 
Range on Protein: 1-154
Range on HMM: 149-301/308.0
TCAQYWPDA---DSVQFGSYSVSTLSTSSDGDMTTRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTnntKEFSILVHCLSGA
.||||||.    .|...| ..| .||. ...|.|.|.|..|  ... |.|||......|| ||  ..  ...||.....|..|    ..  |.|||  | 
kcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps..peilldflelvrksl...pggpivVHCsaGv

GRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
||||.|...  .. |. ..  ||.|..|| ||  |.. |||.| | |.|... |||..
GRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1-156 4.5e-41 136.0 In-house 140-294 (298) alignment 
Range on Protein: 1-156
Range on HMM: 140-294/298.0
TCAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRT
.. .||||  . ..|. .|| ||. . .|...|.|||.... .....| | .|  || .|  ..  |.|.|.|.| |. |...... ...|.| .| ||.
kyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpen..atsvldllrkvrasqqqagnkpvivqCsaGvgRs

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
| |.     . .. .  .||.||.||.||..|.. |||||.|.|.|... |.|.. |
GtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1-154 6.9e-40 131.8 In-house 92-244 (250) alignment 
Range on Protein: 1-154
Range on HMM: 92-244/250.0
TCAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTSH-TVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRT
|. ||||   . ..|.  || ||.   .|.|.|.||.....|... .| |..|  ||  |  ..  |.. |.|.. |..| .....  ..|.| .| ||.
tyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPev..atavLellkkvqasqqqagnaPvivqCsaGvgrs

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
| |..    . .. .   ||.|. .|.||.||.. |...| | ||| .| ..| .
Gafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
Y_phosphatase Protein-tyrosine phosphatase 1-148 2.6e-39 130.4 Pfam-A 83-233 (235) alignment 
Range on Protein: 1-148
Range on HMM: 83-233/235.0
TCAQYWP--DADSVQFGSYSVSTL-STS-SDGDMTTRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTnNTKEFSILVHCLS
.||||||  . .|...|...| .  ...  . ..|.|.|... . .   ...|.|.....||.||  ..  ..|||.|||.|..|. ..|. ...|||  
kcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsa

GAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
|.||||.|.... .. |. ....||..|.|| ||. |.. ||..|.|.|.|..|
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 1-148 2.6e-39 130.4 In-house 83-233 (235) alignment 
Range on Protein: 1-148
Range on HMM: 83-233/235.0
TCAQYWP--DADSVQFGSYSVSTL-STS-SDGDMTTRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTnNTKEFSILVHCLS
.||||||  . .|...|...| .  ...  . ..|.|.|... . .   ...|.|.....||.||  ..  ..|||.|||.|..|. ..|. ...|||  
kcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsa

GAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
|.||||.|.... .. |. ....||..|.|| ||. |.. ||..|.|.|.|..|
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1-150 5.4e-38 125.7 In-house 131-277 (288) alignment 
Range on Protein: 1-150
Range on HMM: 131-277/288.0
TCAQYWPDADS-VQFGSYSVSTLSTSSDGDMTTRQLKVTrNSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSsTNNTKEFSILVHCLSGAGRT
.| .||||||  ...||  |  ...   .|...|.| .   .||  ..||||. .|| ||  ..  .. ||.|.| ||  .|. .   |.|||  | |||
kCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPes..kapllellrqvkv.anqadtgpiivhCsaGvGrt

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
|.| ..   | .. . | .|.. ||. ||  |...|||.. | |.|.|. .
gtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1-154 3e-36 119.8 In-house 132-285 (290) alignment 
Range on Protein: 1-154
Range on HMM: 132-285/290.0
TCAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSK--TSHTVTQYQFHGWPKHGSDQQlGARSLLKLIRAVKSSTNNTkEFSILVHCLSGAGR
.| |||||.|. ..| .|.  |. ..  ....|.|.|. ...  ....|||||.  |...|. ..  . .|| . . .|    .. . ||.|||  . ||
kCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtn.pqtillvieemyktqrkrg.ntsivvHCSdtvgr

TGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
..|||.|.  | .  .   .|.|| .| .|  ... |||...| ...... .||..
savfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0041856 (Phosphotyrosine protein) phosphatases II 1-157 3.3e-22 74.4 In-house 66-176 (182) alignment 
Range on Protein: 1-157
Range on HMM: 66-176/182.0
TCAQYWPdadsvqfgsysvstlstssdgdmttrqlkvtrnSKTSHTVTQYQFHGWPKHGSDQqlgARSLLKLIRAVKSstnntKEFSILVHCLSGAGRTG
|. .|||                                 ..  ....||....|| ||       ..||..|..|..     ..  .||||  | ||||
teelywp.................................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtg

VFCTAMECIAQiaqgdSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
... |  .. .     .|.....|| .|  |.. |.|.. | |......|.|.  ..
tlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-157 1e-79 262.6 In-house 129-282 (315) alignment 
Range on Protein: 2-157
Range on HMM: 129-282/315.0
CAQYWPD--ADSVQFGSYSVSTLSTSSDGDMTTRQLkVTRNSKTSHTVTQYQFHGWPKHGSDQQLGarSLLKLIRAVKSStNNTKEFSILVHCLSGAGRT
|.|||||  ||||.|||..|..||...|.|...|.| |||.|..|.||||.||..||..|.|.|..  ||||||..||.. |..||||.||||..|.|||
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrt

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
||.....|..|||....|||.|..||.|||.|...|||||||||.||...|.|.  | 
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2-156 4.8e-75 247.6 In-house 128-280 (515) alignment 
Range on Protein: 2-156
Range on HMM: 128-280/515.0
CAQYWPD--ADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKtSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTKeFSILVHCLSGAGRT
|..||||  .|||.|||..|...|........ |.|.|..... |.||||..|..||..|....  ..||||||..||..... . .....||..|.|||
cgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrt

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
||........|.......||.|..|...|..|...|||.|.|||.|....|.|.  |
Gvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2-158 3.5e-54 178.9 In-house 133-290 (297) alignment 
Range on Protein: 2-158
Range on HMM: 133-290/297.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDQQLGARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTG
||.||.|  ...||. || .||.|.   .  |.|.||... |. . | ||||  ||..  ...  |.||||||  |. . ....|  .|||||.| ||||
caryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

VFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYD
|..|  ...|.. . ..||||..|| || .|...|||.|.|.||| .. |.| .|...
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr
subfamily_PTPRD_pd Subfamily PTPRD 2-156 1.5e-45 150.9 In-house 133-285 (564) alignment 
Range on Protein: 2-156
Range on HMM: 133-285/564.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKV-TRNSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTnNTKEFSILVHCLSGAGRTG
|..|||. .. ..|.. |.  ..    |.. |..|. . .|. |..|.|..|  || ||  ..  |.|||.||| |.... ....  |.||| .| ||||
chkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes..atslLdlirkvraln.epdagPivVhCSaGVGRTG

VFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
.|..   .. .| . . |||.|.|| ||..|   ||||| |.|....| |.|.  |
tfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2-156 6.8e-44 145.2 In-house 131-287 (305) alignment 
Range on Protein: 2-156
Range on HMM: 131-287/305.0
CAQYWPDADSV--QFGSYSVSTLSTSSDGDMTTRQLKVTR--NSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTKEFSILVHCLSGAG
| ||||.. .   .||..||   |...  | ..|.||..   ..| |.||.|||.  || ||  |.  | |||.||. |. . .. |. ..||||  | |
CrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf..atsllslikrvqkdqkkdkgvpllVhCsagvg

RTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
|||||..    . .. . ..||.|. .| ||  ||. ||| ..| |..|.. |.... .
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
0046845 (Phosphotyrosine protein) phosphatases II 2-154 6.7e-42 139.2 In-house 119-276 (284) alignment 
Range on Protein: 2-154
Range on HMM: 119-276/284.0
CAQYWPDAD-SVQFGSYSVSTLSTSSDGDMTTRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNN-TKEFSILVHCLSGAG
||||||. . ....| ..| .||.  ..|.|.| |..|..  .. |.|||......|| ||  ..  ...||...|.|... .|  ..  |.|||  | |
caqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrellenlpgggpivVHCsaGvg

RTGVFCTAMECIAQIAQGD---SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
|||.|.... .. |. ...    ||....|| ||  |...|||.| | |||... ||| .
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0051299 (Phosphotyrosine protein) phosphatases II 2-152 7.8e-42 139.1 In-house 134-286 (288) alignment 
Range on Protein: 2-152
Range on HMM: 134-286/288.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTR-----NSKTSHTVTQYQFHGWPKHGSDQqlGARSLLKLIRAVKSSTNnTKEFSILVHCLSGA
||||||. .|...| ..| .||. ...|.|.|.|.||.      ...|.|||......|| ||  .   ...||...|.|... .  ..  ..|||  | 
caqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd..spellldflrlvrkala.sgggpvvVHCsaGv

GRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
||||.|...  .. |. ..  ||....|| ||  |.. |||.| | |||... |||
gRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
DSPc_SM00195 2-152 2.6e-41 137.1 In-house 111-262 (263) alignment 
Range on Protein: 2-152
Range on HMM: 111-262/263.0
CAQYWPDA--DSVQFGSYSVSTLSTSSDG-DMTTRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTkEFSILVHCLSGAG
|..|||.   .. .||..|| . .. ..  ....|.|..| .  .....|||||...||.|| ...  ..|.|.|.||||.|.... .  |.|||  | |
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpds..tksvlellravkksksts.sgpivVhCsaGvg

RTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|||.|.|.  .. ...... ||||..|| ||  |.. |||.|.|.|.|..| ||.
RtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 2-152 2.6e-41 137.1 In-house 111-262 (263) alignment 
Range on Protein: 2-152
Range on HMM: 111-262/263.0
CAQYWPDA--DSVQFGSYSVSTLSTSSDG-DMTTRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTkEFSILVHCLSGAG
|..|||.   .. .||..|| . .. ..  ....|.|..| .  .....|||||...||.|| ...  ..|.|.|.||||.|.... .  |.|||  | |
cdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpds..tksvlellravkksksts.sgpivVhCsaGvg

RTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|||.|.|.  .. ...... ||||..|| ||  |.. |||.|.|.|.|..| ||.
RtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2-156 3.4e-41 136.4 In-house 131-284 (318) alignment 
Range on Protein: 2-156
Range on HMM: 131-284/318.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRN-SKTSHTVTQYQFHGWPKHGSDQQLgaRSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTG
...|||. .| ..|.  |   .. . .|.. |..||||. .. | .| ||..  || .|. ..    |||.|.| |..  .....  |.||| .| ||||
vhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg..aslldlvrqvskaqqksgagpivvhCsaGvGrtG

VFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
||..    . .|..   ||.||||| ||  |   ||||. | |.|||. |.|.. .
vfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
subfamily_PTPRK_pd Subfamily PTPRK 2-151 5.7e-40 132.1 In-house 128-276 (314) alignment 
Range on Protein: 2-151
Range on HMM: 128-276/314.0
CAQYWPDADSVqFGSYSVSTLSTSSDGDMTTRQLKVTR---NSKTSHTVTQYQFHGWPKHgsDQQLGARSLLKLIRAVKSSTNNtKEFSILVHCLSGAGR
| .|||.  .| .|   |  ..|. . .. .| ..|..   . .  ..| |.|| |||.|  |    |..||||.| ||.|... ..  |.|||..||||
ClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGr

TGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
||.|..    .  | . . ||.|..|| ||. .. .|.||| | |.|||| | 
tGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
0036941 (Phosphotyrosine protein) phosphatases II 2-158 8.6e-40 132.3 In-house 120-283 (297) alignment 
Range on Protein: 2-158
Range on HMM: 120-283/297.0
CAQYWPDA--DSVQFGSYSVSTLSTSS--DGDMTTRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDQqlGARSLLKLIRAVKSSTNNT-KEFSILVHCLSG
||||||.   .|...| ..| .||...  ..|.|.|.|.||  ... |.|||.....||| ||  .   ..|||..|..|..  ... ..  .||||  |
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldfielvrkvlkllpsggpvlVHCsaG

AGRTGVFCTAMECIAQIA---QGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYD
 ||.|.|..|  .. |.        |||...|| ||  |.. |||.| | |.|... |.| . ...
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0040438 (Phosphotyrosine protein) phosphatases II 2-153 1.6e-39 131.4 In-house 128-277 (317) alignment 
Range on Protein: 2-153
Range on HMM: 128-277/317.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDQqlGARSLLKLIRAVKSSTNnTKEFSILVHCLSGAGRTG
||||||. .....| ..| .||.  ....| |.|.|.  ....|.|||.....||| ||  .    ..||....||... .  ..  .||||  | ||||
caqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spdllldfleavreale.dpggpvlVHCsaGvgRtG

VFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
.|..|  .. |. ..  ||....|| ||. |.. |||.| | |.||...||| 
tfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0047943 (Phosphotyrosine protein) phosphatases II 2-152 2.9e-39 130.6 In-house 119-272 (273) alignment 
Range on Protein: 2-152
Range on HMM: 119-272/273.0
CAQYWPDAD---SVQFGSYSVSTLSTSSDGDMTTRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDQqlGARSLLKLIRAVKSSTNNT-KEFSILVHCLSGA
||||||.     |...| ..| .||. ...|.|.|.|..|. ... |.|||.....||| ||  .     |||..|..|..  ... ..  ..|||  | 
caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp..slesllefielvrkalealpsngpvvVHCsaGv

GRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
||||.|...  .. |.  .  ||....|| ||  |.  |||.| | |.|... |||
gRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 2-152 3.3e-38 127.2 In-house 142-289 (297) alignment 
Range on Protein: 2-152
Range on HMM: 142-289/297.0
CAQYWPDADSvQFGSYSVSTLSTSSDGDMTTRQLKVTRnSKTSHTVTQYQFHGWPKHGSDQqlGARSLLKLIRAVKSSTNNT-KEFSILVHCLSGAGRTG
||||||.  . ..| ..| .|..  ....|.|.|.||. .. |.|||..|..||| ||  .   ...||.....|..  ... |.  .||||  | ||||
caqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvpp..slellleflelvrealaelpkggpvlVHCsaGvgRtG

VFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.|..|  .. |.  .  ||....|| ||  |.. |||.. | |.||...|.|
tfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0043336 (Phosphotyrosine protein) phosphatases II 2-152 2.3e-37 124.4 In-house 130-277 (278) alignment 
Range on Protein: 2-152
Range on HMM: 130-277/278.0
CAQYWPdADSVQFGSYSVSTLSTSSDGDMTTRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDQqlGARSLLKLIRAVKSSTNnTKEFSILVHCLSGAGRTG
||||||  .|...| ..| .|.. ...|.|.|.|.||.  .. |.|||.|...||| ||        .||....||..  . ...  .||||  | ||||
caqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..slsllldflkavreale.dsngpvlVHCsaGvgRTG

VFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.|...  .. |.  .  ||....|| ||  |.. |||.. | |.|....|||
tfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 2-153 1.6e-36 120.8 In-house 143-297 (330) alignment 
Range on Protein: 2-153
Range on HMM: 143-297/330.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVT-----RNSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTKEfSILVHCLSGA
|||||||  .| .|   |.   .    |.| |.. |.     .. |.|  |.|. |..||. |   .  .. .|||...||.  ... . .| ||| .|.
caqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe..piGmlkllkkvkklnqqsag.pivvhcsaGv

GRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY-LH
|||| |..    ....     ||.|..|| ||. | | |||.| | |.| |..|| |.
GrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_PTPRB_pd Subfamily PTPRB 2-155 2.5e-36 120.2 In-house 136-288 (293) alignment 
Range on Protein: 2-155
Range on HMM: 136-288/293.0
CAQYWPDA-DSVQFGSYSVSTLSTSSDGDMTTRQLKVTRnSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSST-NNTKEFSILVHCLSGAGRT
| .|||.  ..|..|. .|. .....  | ..|.||... .|....|.||.|  || ||  ..  ...||...|.|.... .....  |.||| .| |||
CeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPek..tktlldfvrtvreaiektaskrPivvhCsaGvGRt

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
|.| .  . . .| . | |||| .|  || .|...||||..| |..... ..|...
GtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
0045450 (Phosphotyrosine protein) phosphatases II 2-152 4.1e-36 120.7 In-house 149-304 (307) alignment 
Range on Protein: 2-152
Range on HMM: 149-304/307.0
CAQYWPDADSV-QFGSYSVSTLSTSSDGDMTTRQLKVTR--NSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNT-KEFSILVHCLSGAG
||||||| ... ..| . | .||.. ....| |.|.||.   .. |.|||.....||| ||  .     .||..|..|..  ... |.  .||||  | |
caqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps..feelldfieevrkaleelpkggpvlVHCsaGvg

RTGVFCTAMECIAQIAQGDS---VDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|||.|..|  .. |. ..     ||....|| ||. |.. ||..| | |.|....|.|
RtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 2-152 6.6e-36 119.4 In-house 94-243 (245) alignment 
Range on Protein: 2-152
Range on HMM: 94-243/245.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDqqLGARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTG
||||||. .|...| ..| .||. ...|.|.|.|.||.  .. |..|..|....|| ||       ..||.....|..  .....  .||||  | ||||
caqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvp..dllellldflefvrkalaedsngpvlVHCsaGvgRtG

VFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.|..|  .. |.     |.....|| ||  |.. |||.. | |.|....|.|
tfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 2-152 8e-36 119.3 In-house 96-246 (249) alignment 
Range on Protein: 2-152
Range on HMM: 96-246/249.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDqqLGARSLLKLIRAVKSSTNNT-KEFSILVHCLSGAGRT
||||||. .|...| ..| .||. . .|.|.|.|..|.   ..|.||...|...|| ||        .||..|.||..  ... |.  .||||  | |||
caqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvp..psfedlldfieavrkaleelpkggpvlVHCsaGvgRt

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
|.|..|  .. |.     ||....|| ||  |.. ||..| | |.|....|.|
GtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 2-153 3e-35 117.4 In-house 106-273 (278) alignment 
Range on Protein: 2-153
Range on HMM: 106-273/278.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTR-----NSKTSHTVTQYQFHGWPKHGSDQQLGARSLLKLIRAVKSSTN------------NTK
||||||. .|...| ..| .||..  .|.|.| |.||      .. .|..||......|| ||.  .   .|.|.|.. ...  .            . .
caqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

EFSILVHCLSGAGRTGVFCTAMECIAQIaqGDSVDIFQTVKILRADRMQ-FVQTEEEYAFVYDVIREYLH
.  .||||  | ||||... |. .. ..  .. ||....|| ||  |..  ||..| | |.|....|.|.
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2-156 2.1e-34 113.8 In-house 128-282 (287) alignment 
Range on Protein: 2-156
Range on HMM: 128-282/287.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDQQLgARSLLKLIRAVKSSTNNTKEfSILVHCLSGAGRT
| ||||. .|| .| |... |.     ... |.|.|....|.   ..|.|||.  |...|  ..  . .|| . . .|.   ...  ||.|||  . ||.
cyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep.qtillvieemyktqrkrgnt.sivvhCsdtvGrs

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
..|| |   | .  .   .|.|| .|  |  ... ||| |.| |..|.. |||.. .
amfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2-156 2.4e-34 113.9 In-house 133-287 (319) alignment 
Range on Protein: 2-156
Range on HMM: 133-287/319.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTS--HTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRT
. .|||... ...| . |  ..     |.  |.||. ..|      .|...|.  || |.  ..  |.|||.|.. .. |...|..  | |||  |.|||
lkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek..atslldllkrirksrektqsgPivvhCsaGvGRt

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
| |..    . .. .   .|.|.||. ||. |   ||..| | |.|....|.... .
GtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0037934 (Phosphotyrosine protein) phosphatases II 2-152 1e-33 112.3 In-house 90-242 (243) alignment 
Range on Protein: 2-152
Range on HMM: 90-242/243.0
CAQYWPdaDSVQFGSYSVSTLSTSSDGDMTTRQLKVTR--NSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNN-------TKEFSILVHC
||||||  ..|..| ..| .||... .|.| | |....   .. ...|..|....|| ||  .     .||.....|..  ..        ..  .||||
caqywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPds..pedlldfldevrefieellsllaldsggpvlVHC

LSGAGRTGVFCTAMECIAQIaqgdSVDIFQTVKILRADRMQ-FVQTEEEYAFVYDVIREYL
  | ||||....|  .. ..    .||....|| ||. |..  |||.. | |.|....|.|
saGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2-158 1.5e-33 111.3 In-house 132-294 (325) alignment 
Range on Protein: 2-158
Range on HMM: 132-294/325.0
CAQYWPDA--DSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKT-SHTVTQYQFHGWPKHGSDQQLGA-RSLLKLIRAVKSST-NNTK-EFSILVHCLSG
||.|||.   .|..||.  |.  .     |   |.|.| . .|  . .| |.|. .|.  | ...  .  |.|.|. ||.     |||    ||||| .|
cavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaG

AGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYD
 |||||| .    .|.. .  .||||. || ||.|| . |.| ..| ..|. . |.. . | |
vGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntd
subfamily_Ptp69D_pd Subfamily Ptp69D 2-161 4.3e-33 109.7 In-house 133-295 (307) alignment 
Range on Protein: 2-161
Range on HMM: 133-295/307.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSK------TSHTVTQYQFHGWPkhGSDQQLGARSLLKLIRAVKSSTNNTkEFSILVHCLSG
||.|||. | ||.|.  | . |... .| . |.|.|... .       |. |.||.. ||.   |     ||.|||||. |..  ..  .  |.|||  |
cakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk..DskvPevargllklieqvrelykln.rsPivvhCsaG

AGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYDQLP
.||.|.| .    . |. . |.||||.||| || .|  .||  | | |.|  . .| .  . |.  
vgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedv
subfamily_PTPN12_pd Subfamily PTPN12 2-154 6.4e-33 108.9 In-house 125-279 (290) alignment 
Range on Protein: 2-154
Range on HMM: 125-279/290.0
CAQYWPDA--DSVQFGSYSVSTLSTSS-DGDMTTRQLKVTRNsKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNnTKEFSILVHCLSGAGR
|..|||.   ....||...|.. .    | |.. |.|||... |.|..|.|.... || ||  ..  | |||.||..|..  . ...  ..||| .| ||
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPss..aksllelielvrelqe.sedaPlvvhCsaGvGr

TGVFCTAM---ECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
||. ..     | . .    ...|.|. |  || .|   |||.| | .||  . |....
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_PTPN6_pd Subfamily PTPN6 2-156 1.9e-32 107.5 In-house 140-301 (306) alignment 
Range on Protein: 2-156
Range on HMM: 140-301/306.0
CAQYWPDADS-VQFGSYSVSTLSTSSDGDMTTRQLKVT--RNSKTSHTVTQYQFHGWPKHGSDQQLGAR-SLLKLIRAVKSSTNNTKEFSILVHCLSGAG
||.||||. .  ..|..||...| .|  | . |.|.|.  ...|....| ||.|. || ||  .. ||  ..|. ... ......... .|.||| .| |
CarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiG

RTGVFCTAMECIAQI---AQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
||| |      . .|        .|| ..||..|. | ..||||. | ||| .|..|..|..
RtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2-154 4.5e-32 106.3 In-house 126-278 (281) alignment 
Range on Protein: 2-154
Range on HMM: 126-278/281.0
CAQYWPDAD-SVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTG
| .|||| . ....| . |.......   . .|..|..|.|  . .|.| ..  || ||  ..  .. ||.  ..|.. |.. .. ....|| .| ||||
ChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPat..tkellefrkevlkltekktkaplvihCsaGvGrtG

VFCTAMECIAQIA-QGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
.. .    . ... .  ..|. ..|. || .|. .|||   |.||| .. ..|. 
tyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2-150 9.3e-32 105.0 In-house 117-264 (283) alignment 
Range on Protein: 2-150
Range on HMM: 117-264/283.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRN--SKTSHTVTQYQFHGWPKHGSdqQLGARSLLKLiRAVKSSTNNTKEFSILVHCLSGAGRT
|.||||   |...| . |.     .   .. ..| .  |  .|..  .. ||. .| . |   |    ||.|.   |.|  .. |.  |.||| .| |||
CsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyge..qaiinslvkf.nkvislqteskkgPivvhCstgiGrt

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
.||..|.  . ..     ||.|..|||.| .||  ||| . | .|.... |
avfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_PTPRG_pd Subfamily PTPRG 2-158 2.3e-31 103.6 In-house 133-293 (563) alignment 
Range on Protein: 2-158
Range on HMM: 133-293/563.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKV-----TRNSK--TSHTVTQYQFHGWPKHGSDQQlgarSLLKLIRAVKSSTNNTKEF-SILVHCL
| .|||  .|...|. .|   ..      |.|.|..      ....  | ..|.||..  || ||. ..    || .|| ..|||. | .|   |.||| 
cdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh....slpvLifvkkssaankaeaGPivvHcs

SGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYD
.|.||||...     . || | ..|..|...| .|| |   |||||.| |..|.. | . ... .
aGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete
subfamily_PTPN9_pd Subfamily PTPN9 2-152 1.2e-30 101.5 In-house 127-290 (297) alignment 
Range on Protein: 2-152
Range on HMM: 127-290/297.0
CAQYWP--DADSVQFGSYSVSTLSTSSDGDMTTRQLKVT-RNSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVK---SS---------TNNTKEF
|.||||  . .| .||..|||.... .  | ..|.|...  . . | .|| .|| .|| .|  ..  | |||.....|.   ..         . .... 
cgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPss..aaslldvlekvrekqalavkelgdewkghpsgP

SILVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
 |.||| .| |||| |.|   |.... . . ||...||| ||. |   .||.| |.| |  . || 
PivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2-155 1.3e-29 98.0 In-house 106-267 (270) alignment 
Range on Protein: 2-155
Range on HMM: 106-267/270.0
CAQYWPDADS----VQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTsHTVTQYQFHGWPKHGSDQQLG----ARSLLKLIRAVKSSTNNTKEF-SILVHC
|..|||        ...|  .| .||.. .    ...|........ . .. .... || ||  .. .    ...|||..|||. |......   .||||
CerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgee.rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

LSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
  | ||||.. .   ..  . .  .||. . .. || |||..||. |.|.|.| ...|| .. 
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2-151 2.6e-29 97.1 In-house 134-278 (315) alignment 
Range on Protein: 2-151
Range on HMM: 134-278/315.0
CAQYWPDAdSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTsHTVTQYQFHGWPKHGSdqQLGARSLLKLIRAVKSSTNNTKeFSILVHCLSGAGRTGV
. .||||   | .| ..|.  |     ..| | | |. ...  ..| |...  ||. |      . .|..||| ||   .|.   .|.||| .| |||| 
aekywpdk.kviyGkitvtrkseevnteytvrtlsvvfgdni.revvqlhytswpdmgv..pkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGt

FCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
|.|    . |.   . .|... .. .|. |.. ||. |.| |.||.. | 
fitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_CG7180_pd Subfamily CG7180 2-153 3.9e-29 96.2 In-house 126-291 (296) alignment 
Range on Protein: 2-153
Range on HMM: 126-291/296.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRN-----------SKTSHTVTQYQFHGWPKHgSDQQLGARSLLKLIRAVKSSTNNT----KEF
. .|||     |.|   | .... .  ....|..|.|..           .    .|...|.  |. .     | . .|..|.| |..  ...    .| 
ypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWele.dkvPlstnalielrrrvrlwrekvdedpeeg

SILVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
 ..|..  ||.|.||....  .. .. . . ||.|. || || .| | |.. ||| ..|||. |.. 
PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2-154 4.5e-29 96.4 In-house 115-270 (274) alignment 
Range on Protein: 2-154
Range on HMM: 115-270/274.0
CAQYWPDADSV----QFGSYSVSTLSTSSDGDMTTRQLKVTRNSKtSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTKEF--SILVHCLSG
||.|.||| ..    ..|  .. . .. .  | . |.| .   .. ...|. | .  || | | ..  |..||.|.. |..| .....   ...||| .|
CavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaG

AGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 ||||.| ..  .. |. .   ||....|  || ||   |||.| | ... .. .||. 
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPN3_pd Subfamily PTPN3 2-149 1.3e-28 94.7 In-house 126-272 (280) alignment 
Range on Protein: 2-149
Range on HMM: 126-272/280.0
CAQYWPDA-DSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTnNTKEFSILVHCLSGAGRT
| ||||.  |....|..||   .....  . .|.| ..... | .....| |.  || ||  ..  . ..|.... |..   ..||  ..||| .| |||
ChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdd..sadflefvervrklr.sgkeePvvvhCsaGigrt

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
||. .   ..| | . ..| . . |. .|  |. .|||.. | || . | 
GvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2-153 7.8e-28 92.7 In-house 140-293 (319) alignment 
Range on Protein: 2-153
Range on HMM: 140-293/319.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNN-TKEFSILVHCLSGAGR
|.||||    .. . . |.  |     . . |.......   |    .||. | |||..|  ..  .  |..|.. |.  |.   .. .|.||| .|.||
csqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy..psdlmrlvkkvrhltskenhranivvhcsaGvGr

TGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE-YLH
|||. .    . .. . . ||....|. || .| ..||   .| |.|  . | .| 
tGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2-154 1.3e-27 92.1 In-house 104-258 (284) alignment 
Range on Protein: 2-154
Range on HMM: 104-258/284.0
CAQYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNN-TKEFSILVHCLSGAGR
|.||||    .. . . |.  | .   ... |.......   |   ...|. | |||..|  ..  .  |..|.. |.  |.   .. .|.||| .|.||
csqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdy..psdlmrlvkkvrhltskenhranivvhcsagvgr

TGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE-YLHT
|||. .    . .. . . ||....|. || .| ..||   .| |.|  . | .|  
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_PTPN14_pd Subfamily PTPN14 2-153 2.5e-27 90.7 In-house 135-297 (300) alignment 
Range on Protein: 2-153
Range on HMM: 135-297/300.0
CAQYWPDA----DSVQFGSYSVSTLSTSSDGDMTTRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDQQL-GARSLLKLIRAVKSSTNNTKE-----FSILV
. .|.|.     ..|.|| . |.|  ... . ..|..||.    ||   ||   |.  ||.||  . . |  | |. ...|.  ||...|       .||
sfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlv

HCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
||. |.|||||  ..   || . .....|| .....||  || .|||   | |||.|. .||.
hCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0051429 (Phosphotyrosine protein) phosphatases II 2-154 9.9e-27 89.7 In-house 63-227 (272) alignment 
Range on Protein: 2-154
Range on HMM: 63-227/272.0
CAQYWP------------DADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRN--SKTSHTVTQYQFHGWPKHGSDQQLgARSLLKLIRAvksstnntkEFS
| .|||            .| .. .| ..| .||..   |.. | | .|.    .....|.......|| ||  |.   ..||.|...         .  
cdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld.........ggp

ILVHCLSGAGRTGVFCTAMECIAQIAQGDSVD--------IFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
.|||| .| .|||... .  .....   . ||        ....|. ||| |...||||| |.|.|....|.| .
vlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
subfamily_PTPN23_pd Subfamily PTPN23 2-154 3.5e-26 86.7 In-house 125-282 (288) alignment 
Range on Protein: 2-154
Range on HMM: 125-282/288.0
CAQYWPDA--DSVQFGSYSVSTLSTSSDGDMTTRQLKVTRN-SKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKS---STNNTKEFSILVHCLSG
...||| .  ..|.|| .||.  |. . . .  |.||.. . ... ..|.  |.. ||..|  .     .||... .|.|   ....  .  ..|||..|
vdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPas..PetllqfldevesayeavqrksktPlvvhCsaG

AGRTGVFCTAMECIAQIAQGDSV-DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHT
 ||||||.  .  .... .|. . || | |. ||..|   ||..|.. |.|... |. . 
vgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_PTPN13_pd Subfamily PTPN13 2-153 1.8e-25 84.8 In-house 119-270 (273) alignment 
Range on Protein: 2-153
Range on HMM: 119-270/273.0
CAQYWPDADSVQFGS---YSVSTLSTSSDGDMTTRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNntKEFSILVHCLSGAG
| .|||.  . .      . |. | .    ... |.|.|.  .|. |. |.. .|  || ||  ..  | .||.... |..  .  ..  |.||| .| |
chrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss..aaellqfvaevrrlqt..dagPivvhcsaGiG

RTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLH
|.|.. |    .  |..  ..|. ..|. ||  |   |||.. | ||| .| | |.
rsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2-156 3.8e-24 79.9 In-house 127-297 (301) alignment 
Range on Protein: 2-156
Range on HMM: 127-297/301.0
CAQYWPDADSV--QFGSYSVSTLSTSSDGDMTTRQLKVT----------------RNSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNT
| ||||...    .||  .|   ..    |.. |||.|.                ...|.|..|.|.|   ||..|  ..   |  |. |  |   ..  
ceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvre..prtvLqviddvihrqqki

KEFSILVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
    ..|||  . .|.||.|.    . |      ||.|| .| .|  ..  |.| | | ..|||| .||. ..
gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_PTPRN_pd Subfamily PTPRN 2-150 4.4e-23 76.4 In-house 142-290 (297) alignment 
Range on Protein: 2-150
Range on HMM: 142-290/297.0
CAQYWPDADSVQFGSYSVSTLSTS---SDGDMTTRQLKVTRNSKTsHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNtKEFSILVHCLSGAGR
|..||||  |  .. | |  .|      |  . .  ||  ..|.|  ||||. |  ||..|   .  |.|||.. | |  |    .  .|.||| .||||
ckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset.rtvtqfhflswpeegvPas..aksllefrrkvnksyrG.rscpivvhcsdGaGr

TGVFCTAMECIAQIAQG-DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
|||..     ......|   .||  |.. || .| ..|.|.... |.. .. |
tGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2-149 4.7e-23 76.6 In-house 87-236 (237) alignment 
Range on Protein: 2-149
Range on HMM: 87-236/237.0
CAQYWPDADS-VQFGSYSVSTLSTSSDGDMTTRQLKVTRNS--KTSHTVTQYQFHGWPKHGSDQQLGArsLLKLIRAV-KSSTNNTKEFSILVHCLSGAG
| .|||..|    .| ..||        | | | | ....   |    . ||||  ||..|  ||  |  ||.. . . . |   ..    ..|| .| |
chkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvg

RTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
|||.|      . |  .   |||.. |. .  ||   .||...| |....| 
rtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0036282 (Phosphotyrosine protein) phosphatases II 2-146 1.6e-21 72.2 In-house 54-164 (174) alignment 
Range on Protein: 2-146
Range on HMM: 54-164/174.0
CAQYWPDadsvqfgsysvstlstssdgdmttrqlkvtRNSKTSHTVTQYQFHGWPKHGSDQQLGarsLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTGV
| .|||.                              . .  .... ||.. .|| ||         ||.....|..  .. ..  .||||  | ||||.
cinywpe..............................lredlerlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGt

FCTAMECIAQIAqGDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
.. |. .. ..   . ||....|. ||  |.. |||.. | |.|.
lvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2-147 1.1e-20 68.8 In-house 93-235 (239) alignment 
Range on Protein: 2-147
Range on HMM: 93-235/239.0
CAQYWPDADSvQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTSH-TVTQYQFHGWPKHGSDQQlgARSLLKLIRAV-KSSTNNTKEFsiLVHCLSGAGRT
| |||||. | ..    |.   |    |   | . ...  .|    | ||.|  || .|  |   | ..| | | . | |   .. .  ..|| .| |||
chqywpdsts.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpw..vihcsagvgrt

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
| |      . |  .  .||||. || .| || ..||| |.| |..  
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2-147 1.3e-20 68.6 In-house 94-236 (239) alignment 
Range on Protein: 2-147
Range on HMM: 94-236/239.0
CAQYWPDADSvQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTSH-TVTQYQFHGWPKHGSDQQlgARSLLKLIRAV-KSSTNNTKEFsiLVHCLSGAGRT
| |||||. | ..    |.   |    |   | . ...  .|    | ||.|  || .|  |   | ..| | | . | |   .. .  ..|| .| |||
chqywpdsts.kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpw..vihcsagvgrt

GVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
| |      . |  .  .||||. || .| || ..||| |.| |..  
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2-155 4e-20 66.8 In-house 122-280 (287) alignment 
Range on Protein: 2-155
Range on HMM: 122-280/287.0
CAQYWPDAD-SVQFGSYSVSTLST-SSDGDMTTRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDQQ-LG-ARSLLKLIRAVKSSTNNTKEFSILVHCLSGA
| .|||. .  .. | |||  |.    . . ..| |..     . .. | |...  ||...     .| .|  |.  . .. . . ..   ..||.  |.
cykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGi

GRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
||.|.. . . .. .  .   ||. ..|  ||  |  .||.   . ..|. .  | .|.
GrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_PTPN1_pd Subfamily PTPN1 2-150 1.8e-19 64.6 In-house 113-269 (290) alignment 
Range on Protein: 2-150
Range on HMM: 113-269/290.0
CAQYWPDA---DSVQFG--SYSVSTLSTSSDGDMTTRQLKVTR-NSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTKEF-SILVHCLS
||||||     .....   ...|  .|. .    | |.|...  ... ....... .  ||  |  .     ..||..  |..|   ...    ..|| .
caqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpes..paaflkflfkvresGslssdvGpavihcsa

GAGRTGVFCTAMECIAQIAQGDS---VDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
| ||.| || .  |...| . |    ||| ...  ||  |. ..|| .   | |  | |
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2-157 4.3e-19 63.3 In-house 136-288 (290) alignment 
Range on Protein: 2-157
Range on HMM: 136-288/290.0
CAQYWPDA--DSVQFGSYSV-STLSTSSDGDMTTRQLKVT-RNSKTSHTVTQYQFHGWPKHGSdqqlgARSLLKLIRAVKSSTnnTKEFSILVHCLSGAG
|.||.|.   . . ||...|  ..... | ..  . | |  ..|  .| .  ..   || .       | | | |.| ...    .    . ||| .| |
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv.....alstlallrtlrilr..kasGpvvvhcsaGiG

RTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENY
||| | .   ..  . .| ..|. ..|. ||  |.. || . .|  . ... ..    .|
rtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2-149 6.5e-19 63.1 In-house 113-256 (290) alignment 
Range on Protein: 2-149
Range on HMM: 113-256/290.0
CAQYWPDAD--SVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTSHTVTQYQFHGWPKHgsDQQLGARSLLKLIRAVKssTNNTkefSILVHCLSGAGRT
||.| |..   ...|.  .|.  |   . |. ||.| |. . .  .||| ....|| |     |   ..||.||. ||  ...|    ..|||  |  | 
CakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnkl..nvqedtktllsliqkvk..askt...pvivHcvdGiSrs

GVFCTAMECIAQIA-QGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
 .. .       || . .|| . . .| ||  | . .....|.|||  .| 
AalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
0046846 (Phosphotyrosine protein) phosphatases II 2-152 7.2e-19 63.7 In-house 65-173 (176) alignment 
Range on Protein: 2-152
Range on HMM: 65-173/176.0
CAQYWPDADSVQFgsysvstlstssdgdmttrqlkvtrnsktshtvtQYQFHGWPKHGSDQQlgaRSLLKLIRAVKSSTNNTkeFSILVHCLSGAGRTGV
|..|||.  ....                                  ||....|| ||  .    . ||.|......  ..     .||||  | ||||.
cpnywpeleklgi..................................qylhlpwpDhgvpdl...elllellefirealkeg..gpvlVHCsaGigRtgt

FCTAMeciaQIAQGDSVDIFQTVKILRADRM-QFVQTEEEYAFVYDVIREYL
.. |      .  .  ........ .|. |. . |||.| | |.|......|
lvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellll
0051082 (Phosphotyrosine protein) phosphatases II 2-148 1.8e-17 58.8 In-house 49-149 (151) alignment 
Range on Protein: 2-148
Range on HMM: 49-149/151.0
CAQYWPDADsvqfgsysvstlstssdgdmttrqlkvtrnsktsHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSstnnTKEFSILVHCLSGAGRTGV
|..|.|...                                  ..|.......|| .| ..     ..|...... .    .|.  .|||| .| ||||.
cpeylpelg..................................ievlhipildwpdpglpls..fdavleflellld....kkngpvlvHCsaGkgRTGt

FCTAMECIAQiaqgdsVDIFQTVKILRADRMQFVQTEEEYAFVYDVI
.. .. .. .      |....... .|. |. .||..... |.. ..
lvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal
0049260 (Phosphotyrosine protein) phosphatases II 2-146 1.8e-15 52.4 In-house 51-144 (152) alignment 
Range on Protein: 2-146
Range on HMM: 51-144/152.0
CAQYWpdadsvqfgsysvstlstssdgdmttrqlkvtrnsktshtvtQYQFHGWPKHGSDQQLGARSLLKLIRAVKsstNNTKEFSILVHCLSGAGRTGV
|.||.                                          ||... || ||  .       | |.       .  |.  .||||  | ||||.
ceqyi..........................................qylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgt

FCTAMECIaqiaqgDSVDIFQTVKILRADRMQFVQTEEEYAFVYD
.. |  ..        |.....|. .|. |.. |.... . |.|.
lvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2-149 1.1e-14 49.1 In-house 118-292 (297) alignment 
Range on Protein: 2-149
Range on HMM: 118-292/297.0
CAQYWPDADS--VQFGSYSVSTLSTSSDGDM--TTRQLKVTRNsKTSHTVTQYQFHGWPKHGSDQQLG---------------ARSLLKLIR--------
|| |||...    . |.. |  ||. ||        .|..    . |  |.  || .|| ||   .|                   .| |.         
capywpsvvqerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvfl

AVKS-STNNTKEFSILVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
 ..|  ..  ..  .|||| .| ||.||   ..  .|.. ..   |.   ..|||  | . ||| |.. ..||.. 
qleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2-155 1.8e-14 48.4 In-house 117-273 (285) alignment 
Range on Protein: 2-155
Range on HMM: 117-273/285.0
CAQYWPD--ADSVQFGSYSVSTLSTSSDGDMTT--RQLKVTRNSKT-SH--TVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSStnNTKEFSILVHCLS
|| |.|.   . |.|| | ..      .    |    | |.    . |    . . |   || . . ..  || ...| . ||    | ||  | ||| .
calyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlaped..arpmielykwvkkv..npkekpicvhcsa

GAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTE
| |||  |     .  .| .   ..... |. .|| |.| ||.  .. |.| |. ||.  |
gvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfige
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2-151 2.1e-13 44.7 In-house 132-285 (301) alignment 
Range on Protein: 2-151
Range on HMM: 132-285/301.0
CAQYWPD--ADSVQFGSYSVSTLSTSS--DGDMTTRQLKVTRNSK--TSHTVTQYQFHGWPKHGSDQqlGARSLLKLIRAVKSSTNntkefSILVHCLSG
|..| |   ..... | ... . .. .  . ... |.|.|.  ..  ...||| ||.. |...|  .  .   | .|.  || | .      |.||| .|
ceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPk..shaelfdlmelvkksek.....PivvhcsaG

AGRTGVFCTaMECIAQ-IAQGDSVDIFQTVKILRADRMQFVQTEEEYAF-----VYDVIREY
 ||.  | .  |..|. .     ... ...| || .| . |||..   .     || .|.||
iGrsvafig.teylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlikey
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2-152 4.4e-13 43.9 In-house 70-221 (255) alignment 
Range on Protein: 2-152
Range on HMM: 70-221/255.0
CAQYWPDA--DSVQFGSYSVSTLSTSSDGDMTTRQLKVTRN-SKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSStNntkefSILVHCLSGAGR
| .|.|    .  ..   .|.|  .|.|  . |...  |    |  |||. |...||... . ..  || .|.....|. |       |..||| .| ||
cssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel..areilnilkvvrds.k.....svvvhCstGiGr

TGVFCTAmECIAQ-----IAQGDSVD--IFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.  |  | | . |     . . . |.    . .. ||  | . ..|  . ||   .. ...
saafvla.elvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2-157 4.5e-13 43.5 In-house 138-293 (305) alignment 
Range on Protein: 2-157
Range on HMM: 138-293/305.0
CAQYWPDADSVQF---GSYSVSTLSTS----SDGDMTTRQLKVTRNSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSStnntkEFSILVHCLS
|||||| |   .    .   |  .| |     | ..    |..| . . . .| . |.  ||  |        . |.|. |.. |     .  |.||| .
caqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppc..kltslellsairgs.....kvpivvhcsa

GAGRTGVFCTAMECIAQIAQGDSV-DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHtENY
| ||||   .    . .||.  ..  . . || || .|   .|.. .| |.. |. .|.  |.|
gigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl.eky
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2-144 1e-12 42.2 In-house 133-280 (302) alignment 
Range on Protein: 2-144
Range on HMM: 133-280/302.0
CAQYWPD--ADSVQFGSYSVSTLSTSSDGDMTTRQ-------LKVT---RNSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNtkefsIL
||.|. |   . ..|| |.| |.|   | .  | .       ....   ...|. .||   .| .||.||. ..  | . |....  .|  .|     .|
caeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapke..aytaldilkfcesykkn.....vl

VHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFV
|||  | |||| . .    |   .. .  |. . |. .|. |   ||.|.   ..
vhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 2-145 1.7e-11 38.5 In-house 76-220 (263) alignment 
Range on Protein: 2-145
Range on HMM: 76-220/263.0
CAQYWPDAD--SVQFGSYSVSTLSTSSDGDMTTRQLKVT-RNSKTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSStnntKefSILVHCLSGAGR
| .|.|       ..   .|.|  . ||  . |..|  |  . |. |||..|.. ||...   ..  ||. |....... |    |  |. ||| .| ||
cssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpel..areilnilkvarns....k..slvvhcstGiGr

TGVFCTAmECIAQ-----IAQGDSVDI--FQTVKILRADRMQFVQTEEEYAFVY
.  |  | | . |     . . . |..   . .. ||  | . ..|    ||  
saafsva.ElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2-151 2.6e-09 31.1 In-house 123-268 (281) alignment 
Range on Protein: 2-151
Range on HMM: 123-268/281.0
CAQYWPDAD--SVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTsHTVTQYQFHGWPKHGSDQqlGARSLLKLIRAVKSSTNntkefSILVHCLSGAGRT
||.|.|      .||  .|||   .. .  . | .|... . .| . .|.. .. ||     .   .  .||..| ... .        ..|| .| ||.
caeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyeget.rlithwlwkewpdwqvpe..ssevmlkilrkirarst.....ppvihcsagvgrs

GVFCTAMECIAQIAQ-GDSVDIFQTVKILRA-DRMQFVQTEEEYAFVYDVIREY
| . .   ..  |       || | |  ||   |   ||| ..| ... |. ..
gtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_egg_pd Subfamily egg 2-150 2.4e-07 24.7 In-house 123-268 (307) alignment 
Range on Protein: 2-150
Range on HMM: 123-268/307.0
CAQYWPDA--DSVQF--GSYSVSTLSTSSDGD--MTTRQLKVTRNSKTSHTVTQYQFHgWpKHGSDqqlgARSLLKLIRAVKSSTNntkefSILVHCLSG
|  ||| |  ||...  ||. . .|   |  |  ..  .||.    .    .  .|   . .. ||      | |...| ..  ..      ..|..  |
ceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgd.v.nnssd....vysplrvlrklrnlsk.....pvvvqdilG

AGRTGVFCTAMECIAQIAQGDS--VDIFQTVKILRADRMQFVQTEEEYAFVYDVIRE
  ..... ..   . .. .|      . ..|. ||  |   |..   | ||| ..  
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2-149 8e-07 22.8 In-house 150-299 (332) alignment 
Range on Protein: 2-149
Range on HMM: 150-299/332.0
CAQYWPDADSV-QFGSYSVSTLSTSSDGDMTTRQLKVTRNSKtSHTVTQYQFHGWPKHG--SDQQLGARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGR
| ..||.  |  .| . |. .    |.  | | .| || . .  |     .|. |       .  |  |. .||     |         |.. | .|  .
crkfwpekrskkdfpalsiqasddhsethmktfnltvtekkq.dhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvcigpimlvcatgvek

TGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
  ...|    ...|..   | . .|.  .. .|.  ..|   |.   ... 
caisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlm
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 3-160 1.2e-16 55.7 In-house 125-288 (307) alignment 
Range on Protein: 3-160
Range on HMM: 125-288/307.0
AQYWPDADS--VQFGS---------YSVSTLStsSDGD-MTTRQLKVTRNsKTSHTVTQYQFHGWPKHGSDQQ-LGArslLKLIRAVKSSTNntkefSIL
 ||||  .     ||.           . .|.   | | .   .|||    . | |....|.. || .|  |  |.|   . |. ||.  ||      ..
eqywpleegqklvfgeapntisvanlgakkla..pdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqinlta...inlleavrydtn.....pvv

VHCLSGAGRTGVFCTAMECIAQIAQGD-SVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL---HTENYDQL
||| .| ||.|   .      .. .|    |. . |. ||..|   .||| .| ... |. ||.   . | |..|
vhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel
0044763 (Phosphotyrosine protein) phosphatases II 3-153 4.4e-14 48.0 In-house 67-172 (178) alignment 
Range on Protein: 3-153
Range on HMM: 67-172/178.0
AQYWPDADSvqfgsysvstlstssdgdmttrqlkvtrnsktshtvTQYQFHGWPKHGSDQ-QLGARSLLKLIRAVKSstnnTKEFSILVHCLSGAGRTGV
 .|||.  .                                     ||.. ..| ||  .     . ....|... .    .|.  .||||  | ||.|.
dpywpeeag....................................iqylhipipDhgvpdllehflefvefieeald....ekggpvlVHCsaGvgRsgt

FCTAMECIAQiaqgdSVDIFQTVKILRADRMqFVQTEEEYAFVYDVIREYLH
.. |  .. .     ...... .. .|. |. .|.... . ..|.. ...| 
lvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 4-152 5.8e-20 66.1 In-house 130-279 (439) alignment 
Range on Protein: 4-152
Range on HMM: 130-279/439.0
QYWPDADSVQFGSYSVSTLSTSSDGDMTTRQLKVTRNS---KTSHTVTQYQFHGWPKHGSDQQlgARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTG
.|||  . | .|  .| .       . . | .||  .    .  .|| |...  ||..    |  |  .|...||..|. .. .   ..||| .| ||||
kywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeeygpvvvhcsagvGrtG

VFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
   .   .. |.   . |||   ||.|| .| |.||.  .| |.|. . | .
tiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 4-147 7.2e-13 43.1 In-house 49-199 (199) alignment 
Range on Protein: 4-147
Range on HMM: 49-199/199.0
QYWPDADS--VQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKT---SHTVTQYQFHGWPKHGSDQQLGARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGR
 ||| ..|   ..|| ||.| . ..  |.|   | .| |. .   .  ...|||  | .. . .      ..   | |    .. |.  ..|||  | | 
fywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgf

TGVFCTAMECIA--QIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
|||| .    .   . ..   ||.|.  | ||  |   . . . | |.|.|
tgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 4-147 7.2e-13 43.2 In-house 48-198 (198) alignment 
Range on Protein: 4-147
Range on HMM: 48-198/198.0
QYWPDADS--VQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKT---SHTVTQYQFHGWPKHGSDQQLGARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGR
 ||| ..|   ..|| ||.| . ..  |.|   | .| |. .   .  ...|||  | .. . .      ..   | |    .. |.  ..|||  | | 
fywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgf

TGVFCTAMECIA--QIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDV
|||| .    .   . ..   ||.|.  | ||  |   . . . | |.|.|
tgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_eak_pd Subfamily eak 4-156 9.9e-09 29.0 In-house 137-309 (332) alignment 
Range on Protein: 4-156
Range on HMM: 137-309/332.0
QYWPDAD--SVQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTsHTVTQYQFHGWPKHGS------------DQQLGARSLLKLIRAVKSSTNN-----TK
.|.||     ..|| . | . .    . . ||.|....  .| | |  |...|| .                .. |.  |.    |. ||| .       
kyfpdktreelkfGildverkefvkrniletrllelskGnet.hrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtpp

EFSILVHCLSGAGRTGVFCTAMECIAQIAQ--GDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
 |. .. .  |. |.|||      |  | .   ..  . . .   .  |.  | .. ...|.|... .|| . |
sfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 12-154 3.2e-13 44.1 In-house 153-289 (305) alignment 
Range on Protein: 12-154
Range on HMM: 153-289/305.0
VQFGSYSVSTLSTSSDGDMTTRQLKVTRNSKTSHTVTQYQFHGWPKHGSDQqlGARSLLKLIRAVKSSTNntkefSILVHCLSGAGRTGVFCTAMECIAQ
|.| | .   . .... ..|  .| .    .... ||.| .  ||  |        ..|.|.   ..|        | ||| .| ||||        . |
vkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa..adlailellekarpskg.....pivvhcsagigrtgsvvmleyildq

IAQGDSVDIFQ-TVKILRADRMQFVQTEEEYAFVYDVIREYLHT
. .|. ..  .  .. .| .| . .||...| ||..|| .|.. 
llagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_ptpA1_pd Subfamily ptpA1 13-108 2.3e-14 48.0 In-house 153-252 (418) alignment 
Range on Protein: 13-108
Range on HMM: 153-252/418.0
QFGSYSVSTLSTSSD--GDMTTRQLKVTRNSKTShTVTQYQFHGWPKHG-SDQQLGARSLLKLIRAVKS--STNNTKEFSILVHCLSGAGRTGVFCTAME
 ||.|||  .    |   .. ||....| . .|   .||||. ||| |   |.    | ||. |   .     .. ..  |.||| .| |||| ||||. 
vfgtysvelveviqdpereiitrnirltfegetr.ditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavi

C
 
m
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 18-159 2.9e-96 317.3 In-house 251-392 (392) alignment 
Range on Protein: 18-159
Range on HMM: 251-392/392.0
SVSTLSTSSDGDMTTRQLKVTRNSKTSHTVTQYQFHGWPKHGSDQQLGARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTGVFCTAMECIAQIAQGDS
 ...||||||||....|||..|..|.||||||||||||||||||||.|||||||||||||.|||..||||||||||||||||||||||||||||||.|||
hlqdlstssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegds

VDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYLHTENYDQ
||||||||||||||||||||||||||||||||||||||.|.|
vdifqtvkilradrmqfvqteeeyafvydvireylhtekyeq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 25-156 2.1e-12 41.4 In-house 155-280 (312) alignment 
Range on Protein: 25-156
Range on HMM: 155-280/312.0
SSDGDMTTRQLKVTRNS-KTSHTVTQYQFHGWPKHGSDQQLgaRSLLKLIRAVKSSTNntkefSILVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQT
 |   .| | |||  ..      . .||.  || ||  .     . |.|. |||   .      .. || .| |||| ..     || . .    .. ..
kskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdsc..dtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrhprkqnvkds

VKILRADRMQFVQTEEEYAFVYDVIREYLHTEN
  .|| || . |..  .| ..  .. |.|... 
fvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 26-152 1.5e-15 51.9 In-house 139-259 (267) alignment 
Range on Protein: 26-152
Range on HMM: 139-259/267.0
SDGDMTTRQLKVtrNSKTSHTVTQYQFHGWPKHGSDQQLgARSLLKLIrAvKSSTNNTkEFSILVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVK
 | .. | .||.  . ...| || | .. |     ..    . |. .. | |   .|  .  ..|.|  | ||.| | ..   . .. . . .|||. ..
ndyqiitlelkf..knesahnvtlyyykkwnintnnkpy.lkplfgil.a.knqleng.nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflr

ILRADRMQFVQTEEEYAFVYDVIREYL
 .|  |. .|.| |.| ...... || 
kirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 27-152 1.4e-08 27.7 In-house 186-309 (346) alignment 
Range on Protein: 27-152
Range on HMM: 186-309/346.0
DGDMTTRQLKVTRNSKTSHTVTQYQFHGWPKHgSDQQLGARSLLKLIRAVKSStNNTKEFSILVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKI
 ||     ..|  . ..   . | . |   ||  .|   .  ..|.|   .|  .. ..  . |  | |.||.  |  |.  | |. .|   .|.. .| 
sgdpkeytievlpegnsdsvicqvhhhapwkh.lqqppktlpiikmihqflse.kqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimkn

LRADRMQFVQTEEEYAFVYDVIREYL
.. .|   |..  .|| .| .. .|.
ikqqrpggvesfaqyasiyaivfdyi
PTPc_motif_SM00404 31-110 1.5e-06 23.1 In-house 28-104 (140) alignment 
Range on Protein: 31-110
Range on HMM: 28-104/140.0
TTRQLKVTRNSKTSHTVTQYQFHGWPKHGSDQQLGARSLLKLIRAVKSStnNTKEFSILVHCLSGAGRTGVFCTAmECIA
 |  ..||.. . .    ..|.   | . ....  .. | |... ....  ..|. ..||||  |  |.. ...| ... 
ithvinvteevsltkensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliia.Ylmr
DSPc Dual specificity phosphatase, catalytic domain 32-105 4.2e-06 21.7 Pfam-A 20-93 (133) alignment 
Range on Protein: 32-105
Range on HMM: 20-93/133.0
TRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDQQLGARSLLKLIRAVKSStnNTKEFSILVHCLSGAGRTGVFCTA
|  . ||.. .   . . ..... . | . ....  .. | .... ...    .|. ..||||  |. |.. ...|
tlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliia
DSPc Dual specificity phosphatase, catalytic domain 32-105 4.2e-06 21.7 In-house 20-93 (133) alignment 
Range on Protein: 32-105
Range on HMM: 20-93/133.0
TRQLKVTRNSKT--SHTVTQYQFHGWPKHGSDQQLGARSLLKLIRAVKSStnNTKEFSILVHCLSGAGRTGVFCTA
|  . ||.. .   . . ..... . | . ....  .. | .... ...    .|. ..||||  |. |.. ...|
tlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliia
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 33-152 3.1e-09 30.6 In-house 206-344 (349) alignment 
Range on Protein: 33-152
Range on HMM: 206-344/349.0
RQLKVTRNSKTSHTVTQYQFHGWPKHgsDQQLGARSLLKLIRaVKSS----------TNNTKEFSILVHCLSGAGRTGVFCTAMECIA--QIAQGDSVD-
 .  .. ...  . . | |.  |.       |   |.|. .  ||.            .. .  ..|||| .| |||||..|    ..  .  | .|.  
dddaillavekPyellqlqvknwldl..slllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnki

---------IFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
         |. .| .||  |.. ||   .. ..|. . .|.
klqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
0048179 (Phosphotyrosine protein) phosphatases II 34-146 3.6e-16 54.6 In-house 48-139 (144) alignment 
Range on Protein: 34-146
Range on HMM: 48-139/144.0
QlkvtrnsktshtVTQYQFHGWPKHGSDQQLgaRSLLKLIRAVKSSTNntKEFSILVHCLSGAGRTGVFCTAMECIaqiAQGdsVDIFQTVKILRADRMQ
.            ..||.. .|| ||  . |    ||........  .  ..  .||||  | ||||....|  ..    .|  ........ .|. |..
e............giqylhlpwpDhgvpdll..ellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpg

FVQTEEEYAFVYD
 |.... . |...
avpnpgqlrfLle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 34-159 2.3e-14 48.1 In-house 160-278 (288) alignment 
Range on Protein: 34-159
Range on HMM: 160-278/288.0
QLKVTRNSKTSHTVTQYQFHGWPKHGSDQQLgaRSLLKLIRAVKSSTNntkefSILVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQ
 |..... ...  | .  .. |...|  ..    | |.|.  .|| ..      |.||.  |.|||| .   .  . ..   | . | . .. ||..|..
llriskegeekvivkilhlleWdddgvPeny..lsplrllevlkslqk.....PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfk

FVQTEEEYAFVYDVIREYLHTENYDQ
 .|||  | .|. .. |.|    | .
aiqtemqylyvhrcvleelllkkykv
0043147 (Phosphotyrosine protein) phosphatases II 40-146 1.8e-17 59.1 In-house 58-155 (172) alignment 
Range on Protein: 40-146
Range on HMM: 58-155/172.0
NSKTSHTVTQYQFHGWPKHGSDqqlGARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTGVFCTAMECIaqiaqgDSVDIFQTVKILRADRMQFVQTEE
 .. .... ||....|| ||      .. ||.... ...  .. ..  .||||  | ||||... |  ..       .......|. .|. |.. ||...
pellerlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

EYAFVYD
 | |.|.
qyrflyy
0048076 (Phosphotyrosine protein) phosphatases II 41-151 6e-17 57.1 In-house 41-142 (145) alignment 
Range on Protein: 41-151
Range on HMM: 41-142/145.0
SKTSHTVTQYQFHGWPKHGSDQQLgaRSLLKLIRAVKSSTNNTkeFSILVHCLSGAGRTGVFCTAMECIAqiaqgDSVDIFQTVKILRADRMQFVQTEEE
.  .....||.. .|| ||  . |  . ||........  ..     .||||  | ||||... |. ..       .|....... .|. |...|.... 
ellerlgiqylylpwpDhgvpdll..ellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgq

YAFVYDVIREY
. |.|....|.
lrflyefelel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 42-154 2.1e-21 70.8 In-house 86-196 (440) alignment 
Range on Protein: 42-154
Range on HMM: 86-196/440.0
KTSHTVTQYQFHGWPKHGSDQQLGarSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEY
  |.|. ||...||| .|  .  |   .||.|. |. | ... .  .|||| .|||||||  .    . .  . | .|||  .. .| .| |.||| |.|
iesrtlkqyhyqgwpdkgvpkfag..pvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

AFVYDVIREYLHT
|||.... | | .
afvheavlegllc
0049772 (Phosphotyrosine protein) phosphatases II 44-153 1.5e-14 49.9 In-house 177-281 (314) alignment 
Range on Protein: 44-153
Range on HMM: 177-281/314.0
SHTVTQYQFHGWPKHGSDQQLGARSLLKLIRAVksstnnTKEFSILVHCLSGAGRTGVFCTAMECIAQIaqgdSVDIFQTVKILRADRM-----QFVQTE
.... .|  . .| .. .     ...|..|...       |.  .|||| .| ||||.|..|. .. .      |.. .... .|. |.      |... 
erlgikylripvpDgsaplledfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieql

EEYAFVYDVIREYLH
|.| |......||| 
eqyefilealleylk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 45-162 2.8e-07 24.5 In-house 171-289 (303) alignment 
Range on Protein: 45-162
Range on HMM: 171-289/303.0
HTVTQYQFHGWPkHGSDQQLGARSLLKLIRAVKSSTNN-TKEFSILVHCLSGAGRTGVFCTAME-CIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYA
  .  .... || |.|    |.  ..| |  ..|   . ..    .   ||| ||.| |.      ..  ..  |.|. . .. .|  |.. ||   ...
sflhvhhykawp.hnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfs

FVYDVIREYLHTENYDQLPY
.|| .. |..  . . .|  
vvytllaehvldngicklai
PTPc_DSPc_SM00012 46-149 1.5e-28 94.5 In-house 1-104 (105) alignment 
Range on Protein: 46-149
Range on HMM: 1-104/105.0
TVTQYQFHGWPKHGSDQQLgaRSLLKLIRAVKSSTNNTK-EFSILVHCLSGAGRTGVFCTAMECIAQIAQG-DSVDIFQTVKILRADRMQFVQTEEEYAF
||..|...|||.||  ..    |.|.|.||||...|. . . ...|||  |.||||.|...  .. |. .. ..|||||.|| ||  |.. |||||.| |
tvkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

VYDVIR
.|... 
lyrall
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 50-154 1.2e-11 38.6 In-house 186-287 (302) alignment 
Range on Protein: 50-154
Range on HMM: 186-287/302.0
YQFHGWPKHGSDQQLGArsLLKLIRAVKSSTNNTKEfSILVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIR
| .. |...   .. ..  | | .  |  .. ...| ....    |||| |.| |..  . .. .|. . | ..|| .|..| . |.. . |...| .. 
yvltnWkqkkvpvkyae..liktaakvfakkikade.ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

EYLHT
 |. .
lyikk
subfamily_PTPDC1_pd Subfamily PTPDC1 64-147 9e-08 26.8 In-house 93-171 (182) alignment 
Range on Protein: 64-147
Range on HMM: 93-171/182.0
LGARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTGVFCTAMECIAQIAQGDsvdifQTVKILRADRMQFVQTEEEYAFVYDV
 |..|| ...  ||  .   .|  . ||| .| |||||  ...   |.  ...     ...|..|. | . .|| |   .| . 
ygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvkef
0038934 (Phosphotyrosine protein) phosphatases II 65-104 1.5e-06 23.5 In-house 95-134 (194) alignment 
Range on Protein: 65-104
Range on HMM: 95-134/194.0
GARSLLKLIRAVKSSTNNTKEFSILVHCLSGAGRTGVFCT
    ||. ...|.  .|. ..  ..|||  | ||||... 
sleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_CG42327_pd Subfamily CG42327 74-151 2e-14 48.0 In-house 235-314 (319) alignment 
Range on Protein: 74-151
Range on HMM: 235-314/319.0
RAVKSS-TNNTKEFSILVHCLSGAGRTGVFCTAMECIAQIAQG-DSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREY
  . |   .. .   . |||  |.||||.  ..   | .. .   |||| |.|  .| || . |.| | |.|.| |. ||
gnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 75-152 6.9e-11 36.5 In-house 252-344 (350) alignment 
Range on Protein: 75-152
Range on HMM: 252-344/350.0
AVKSSTNNTKEFSILVHCLSGAGRTGVFCTAMECIA-----QIAQGDSV----------DIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
  .|  .| .  .||||| .| ||||...|    .      .  . .|.           |...|..||  |.. ||. . . |.|. .. | 
faeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 89-152 3.8e-14 46.8 In-house 2-65 (69) alignment 
Range on Protein: 89-152
Range on HMM: 2-65/69.0
LVHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
.||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  | || |..| . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 90-152 3e-14 47.1 In-house 2-64 (69) alignment 
Range on Protein: 90-152
Range on HMM: 2-64/69.0
VHCLSGAGRTGVFCTAMECIAQIAQGDSVDIFQTVKILRADRMQFVQTEEEYAFVYDVIREYL
||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  |.|| |..| . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal