Gene SpurPTP-sf1-5 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily SpurPTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP082_AA protein Get Run
SpurP082_AA_326-559 phosphatase_domain Get Run
SpurP082_AA_571-845 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
fn3 Fibronectin type III domain 176-255 1.3e-07 24.8 Pfam-A 19-79 (85) alignment
Range on Protein: 176-255
Range on HMM: 19-79/85.0
QWDPRSdTGDGPIVGYKIYVRSGRNVVlakevqppsmvnktdrsVSKRSAENATEMvMYNASGLEPGSTYSVQIAAIRDG
.|.| . .|.|||.||.. .|. ..                   ..|.    .|..  .. .||.||..|.....|. ..
sWsppk.dgggpitgYeveyrekggge.................ewkeftvprttt.svtltgLkpgteYefrVqavnga

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 322-449 1.7e-50 166.9 In-house 6-131 (297) alignment
Range on Protein: 322-449
Range on HMM: 6-131/297.0
KRQPIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNdkAYIASQGPNIA
.|.|||...|......|||. .|| ||..||   |.|||||.| .|..|.|||||||||| ||||....| | |||.|||..... .   .|..| |. |
errpiplsdfatlvqknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

SMDDFWRMVWQENVTTIAMVTKLKEGDK
...|||.||..|.|.||.|.....|.||
tvadfWamvldeqvstivmlnddnerdk

subfamily_PTPRA_pd Subfamily PTPRA 322-448 3.7e-34 113.1 In-house 10-139 (330) alignment
Range on Protein: 322-448
Range on HMM: 10-139/330.0
KRQPIPVAQFPAFIENN--RHSALFSGEFHDLPGPDIYP-QTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGP
|  |.|| ..   |.      . ||  ||  ||  .|     .|.|| | .|||. |||||| .|| | |.. ...||| |||.|  . . . .||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

NIASMDDFWRMVWQENVTTIAMVTKLKEGD
   ...|||||.|. . .|| |.|.||| .
keetvedfwrmiweqksativmltelkerk

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 323-598 1.9e-178 587.8 In-house 1-276 (392) alignment
Range on Protein: 323-598
Range on HMM: 1-276/392.0
RQPIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIAS
||||||||||||.|.|||||||..|||||||||||||||||||||||||||||||||||||||||||||||.|||.||||||||||.||||||||||.||
rqpipvaqfpafveknrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MDDFWRMVWQENVTTIAMVTKLKEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTR
.|||||||.|||||||||||||||||||||.|||.||||||||||.||||||||||||||||||.||.|||||||||||||||||||||||||||||.||
lddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktr

MVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTLKS
||||||||||||.|||.||||.|||||||||||||||||||||||||||||||||..|.||..|||..|||..||.
mvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvrskqlkefrslka

0050432 (Phosphotyrosine protein) phosphatases II 323-562 3.9e-76 251.6 In-house 23-303 (308) alignment
Range on Protein: 323-562
Range on HMM: 23-303/308.0
RQPIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQ-TVAQKEINLKKNRYKNILPYDSARVKLevidDiPHSDYFNASYIPSF--DNDKAYIASQGPN
  ...| ..  ..|.   . |.. ||..|.   .... .||... | .|||||.|||||. ||||    | ..||| ||||.. .  ......|| ||| 
slklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPl

IASMDDFWRMVWQENVTTIAMVTKLKEGDK---------------------------------------------GDDYRTVTQFHFTEWPDKGVPKHTS
  ...|||||||..||..| |.||| | ..                                             ....||||.||.| ||| ||| ...
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspe

SLLKFIKEVKADHGQftHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRN
.||.|...|.  ...  .| ..||||||||||..| .| .. . .....||||. |  .|..||.|||| ||| |.| |.|| |... 
illdflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

subfamily_PTPRD_pd Subfamily PTPRD 323-449 2.4e-44 146.9 In-house 2-130 (564) alignment
Range on Protein: 323-449
Range on HMM: 2-130/564.0
RQPIPVAQFPAFIENNR--HSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNI
..|||||........ .  ... |. |....  ..  . ..|.|..| .||||.||..||. ||.|. ..  . ||| |||.| .....|||||.|||  
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ASMDDFWRMVWQENVTTIAMVTKLKEGDK
 ...|||||||..|..|| |.|||.| .|
etiedFWRmvweqnsstiVmltkleEkgk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 323-449 5.3e-36 119.1 In-house 3-131 (315) alignment
Range on Protein: 323-449
Range on HMM: 3-131/315.0
RQPIPVAQFPAFIENNRHSA--LFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNI
.||||. |. ... ... |.   |  ..  .|| ...|  ||.|  | .|||| ||..|| .||.| ...  ||||| ||..|. ..  . |||.||||.
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ASMDDFWRMVWQENVTTIAMVTKLKEGDK
||..||||.|..|....| |.|.| ||.|
asvkdfwrlvfeedigkivmltnlvegek

subfamily_PTPRB_pd Subfamily PTPRB 323-449 1.6e-34 114.3 In-house 4-133 (293) alignment
Range on Protein: 323-449
Range on HMM: 4-133/293.0
RQPIPVAQFPAFIENNR--HSALFSGEFHDLPGP-DIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPN
 .|| . .| .......    . || |...|        ...|....| .||||.|||||| .||||. ..| ..||| ||.||| .   . .||.||| 
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

IASMDDFWRMVWQENVTTIAMVTKLKEGDK
  ..||||||||......| |.|.| |. |
petvddfWrmvwekkssiivmltqlvekgk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 323-406 2e-15 51.1 In-house 3-86 (440) alignment
Range on Protein: 323-406
Range on HMM: 3-86/440.0
RQPIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSF
..|| ||.|  ...||| |  |  |.  ||     |  .|    |  ||||.||| || .|| || .  .|.||| ||||| . 
qrpiivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 324-449 7.5e-70 230.2 In-house 1-126 (315) alignment
Range on Protein: 324-449
Range on HMM: 1-126/315.0
QPIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASM
|||||||||||...|||.|||| ||||||.||||.|.||...|| ||||||||||.||||||||||||.|.|||.|||||.|.|.||||||||||. ||.
qpipvaqfpafvnknrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

DDFWRMVWQENVTTIAMVTKLKEGDK
|||||||.||.||||.||||..||||
ddfwrmvlqekvttivmvtkkqegdk

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 324-447 3.5e-34 113.3 In-house 3-128 (319) alignment
Range on Protein: 324-447
Range on HMM: 3-128/319.0
QPIPVAQFPAFIENNRH--SALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIA
..|.|...   ... ..  . |.  ||..| ...    . |.||.| |||||.|||.|| .||.|  .|... ||| |||.| .... ...|| |.|   
teievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

SMDDFWRMVWQENVTTIAMVTKLKEG
 ..|||||||.|.. .. |.|||.| 
tiedfWrmvWeeessivvmltklvek

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 325-449 4.2e-75 247.8 In-house 1-125 (515) alignment
Range on Protein: 325-449
Range on HMM: 1-125/515.0
PIPVAQFPAFIENNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMD
|.|.||||||.. ||| .||| ||||||||.||||||||.||| |||||||||||||.|||||||.| ||||||||||||||||||||||||||| ||.|
plplaqfPafvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd

DFWRMVWQENVTTIAMVTKLKEGDK
||||.|.||||||||||||||||||
dfWrlvlqenvttiamvtklkegdk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 325-449 8.6e-26 85.8 In-house 3-128 (305) alignment
Range on Protein: 325-449
Range on HMM: 3-128/305.0
PIPVAQFPAFIENNRHSA--LFSGEFHDLPGPdIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIAS
.| .... |.|...|      .  ... |.     .  | .|| | .|||.|.| ..|  |..|   .. ..||| ||||. .... |.||..|||    
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

MDDFWRMVWQENVTTIAMVTKLKEGDK
..||||....| |.|| |.|||.||.|
vadfWrliveekvstivmltklveggk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 326-449 5.5e-23 76.2 In-house 2-130 (290) alignment
Range on Protein: 326-449
Range on HMM: 2-130/290.0
IPVAQFPAFIENNRH--SALFSGEFHDLP-GPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPH--SDYFNASYIPSFDNDKAYIASQGPNI
||| .|  |..|..      |  .|. |  |   .  ||.  . | ..||..||..||  |. |  | . .    .| ||.||  . ..|.||| |||  
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ASMDDFWRMVWQENVTTIAMVTKLKEGDK
  . |||...|||.|| | |.|. .| .|
ntlvdFWkliwqekvtiivmltniieegk

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 327-450 8.8e-24 79.0 In-house 3-126 (287) alignment
Range on Protein: 327-450
Range on HMM: 3-126/287.0
PVAQFPAFIENNRH--SALFSGEFHDLPG----PDIYpqTVAQKEINLKKNRYKNILPYDSARVKLEviddIPHSDYFNASYIPSFDNDKAYIASQGPNI
|| .|  |......  .  |.  |  |      .|    |..  . | .|||...||..|  || |.      | || ||..| .. ..||.|....| .
pvekfgefvakghakgnegfknqftvleqvtqredev..thniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmf

ASMDDFWRMVWQENVTTIAMVTKLKEGDKG
  . .||......|||.| |....|| |. 
ntarnfWkliddrnvtaivmlcqekendee

0039614 (Phosphotyrosine protein) phosphatases II 333-563 6.4e-69 228.0 In-house 23-294 (297) alignment
Range on Protein: 333-563
Range on HMM: 23-294/297.0
AFIENNRHSALFSGEFHDLPGPDIyPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDI-PHSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMV
 ..|.   . |.  || .|.   . ....|... | .|||||.|||||. |||| ..|.  ..||| ||||.. .|  ....||.|||.  ...||||||
lllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WQENVTTIAMVTKLKEGDK--------------------------------------GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--F
|...||.| |.|||.| ..                                      ..  ||||.|..| ||| ||| ....||.|...|.  . .   
weqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNT
 .| ..||||||||||..| .. .. . .... |||.. |  .|..|| .||| .|| |.| |.|| |....|
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt

subfamily_Ptp69D_pd Subfamily Ptp69D 333-449 3.3e-30 100.3 In-house 11-130 (307) alignment
Range on Protein: 333-449
Range on HMM: 11-130/307.0
AFIENNRHS--ALFSGEFHDLPGPDIYPQT-VAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRM
  ......    ..  |.. |.   |  .| |..|. |. ||||..| ..|. ||||..|    .||| |||.| .... | .||.|.|  | ..|||||
ealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRm

VWQENVTTIAMVTKLKEGDK
... .||.| |...|.| ..
iaeqevtlivmlsnlteknr

0047943 (Phosphotyrosine protein) phosphatases II 335-556 1.6e-71 236.3 In-house 5-270 (273) alignment
Range on Protein: 335-556
Range on HMM: 5-270/273.0
IENNRHSALFSGEFHDLPGP-DIYPQTVAQKEINLKKNRYKNILPYDSARVKLevidDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQE
.|.  ...|.  ||..|.   .... .||... |..|||||.|||||. ||||    . ..||| ||||.. ..  ...|| |||   ...|||||||..
lekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NVTTIAMVTKLKEGDK---------------------------------------------GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG
||..| |.|.| | ..                                              ...||||.||.|.||| ||| ...|||.||..|.  . 
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

Q--FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
.    .| ..||||||||||..| .| .. . .....|||.. |  .|..|| |||| ||| |.| |.||
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

subfamily_CG7180_pd Subfamily CG7180 337-445 3.3e-23 76.8 In-house 12-120 (296) alignment
Range on Protein: 337-445
Range on HMM: 12-120/296.0
NNRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVT
 ... ... .|..  |  .|     . .. |..|||. ...||| .|| || .|   .||| ||.|. ||  .|.||  ..|   ..|.|||.|..|.. 
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIAMVTKLK
.. ..||  
avvvLtktf

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 338-450 1.5e-21 71.4 In-house 11-125 (301) alignment
Range on Protein: 338-450
Range on HMM: 11-125/301.0
NRHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVID--DIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENV
. ||  |. ....|   .  . ||  .| | . ||.||| .||  |. |.     |. . .| ||||| .. . |..||.|||    . ||||..||| .
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIAMVTKLKEGDKG
..| |||.|||| | 
vsivmvtnlkegtks

0040438 (Phosphotyrosine protein) phosphatases II 339-595 5.7e-76 251.1 In-house 16-313 (317) alignment
Range on Protein: 339-595
Range on HMM: 16-313/317.0
RHsALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTI
 .  ... ||.||.  .... .||... | .||||..|||||. |||| ... ...||| ||||.. ..  ...|| |||   ...|||||||...||.|
df.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

AMVTKLKEGD------------------------------------------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLII
 |.|.|.| .                                          .... ||||.||.| ||| |||.....||.|...|..   .  .|...
vmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlV

HCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQT
||||||||||..| .. .. . .... |||.. |  .|..|| .||| ||| |.| |.|| |....||.|. ..  .|. |.    . . . ..||...
HCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkekelkl

0043336 (Phosphotyrosine protein) phosphatases II 339-556 1.6e-70 233.1 In-house 17-275 (278) alignment
Range on Protein: 339-556
Range on HMM: 17-275/278.0
RHSALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTI
   .|.. ||..|.  .......|... | .|||||.|||||. ||||....  ..||| ||||.. ..  ...||.|||.  ...|||||||...||||
nlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

AMVTKLKEGD-----------------------------------------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIH
 |.|.|.| .                                         . . .||||..|.. ||| ||| ..|.||.|.|.|.       .|...|
vmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVH

CSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
|||||||||..| .. .. ...... ||... |  .|..|| .|||..|| |.| |.||
CsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 341-449 2.3e-33 110.5 In-house 20-129 (288) alignment
Range on Protein: 341-449
Range on HMM: 20-129/288.0
SALFSGEFHDLPG-PDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIA
 . || |.. |.       .|....  | |||||.||||||  ||||.  .. . .|| ||||| . ...|.|||.|||. ....|||..|......||.
rtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstiv

MVTKLKEGDK
|.|.| ||.|
mltelveggk

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 342-447 4e-33 109.8 In-house 20-126 (318) alignment
Range on Protein: 342-447
Range on HMM: 20-126/318.0
ALFSGEFHDL-PGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAM
 |.| |.. | . ..   .. . ...| .|||| |||.||..||||. ... . ||| ||.||. . ..|||||.|.|    ..|||||||. | ..| |
lllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

VTKLKEG
.|...| 
ltqeeer

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 342-449 2.4e-24 80.7 In-house 9-114 (283) alignment
Range on Protein: 342-449
Range on HMM: 9-114/283.0
ALFSGEFHDLPGPDIyPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYIP---SFDNDKAYIASQGPNIASMDDFWRMVWQENVTTI
 ||   .. |  ||  . ..|  . | .|||...|.|.|  ||.|.        || ||..||   | ..|| ||..|.|    . |||.||..|..|.|
klfrevlkrlsvpdl.dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitai

AMVTKLKEGDK
 |.|||.|. .
vmltklqedlr

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 342-417 6.7e-12 39.4 In-house 23-95 (95) alignment
Range on Protein: 342-417
Range on HMM: 23-95/95.0
ALFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphSDYFNASYIPSFDNDKAYIASQG
  |  ||. ..     | ||   | |. |||. ||.|||..|| |    |   ||| || ..  .   ..|||.||
qefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfvdgyarkncyiaaqg

0051299 (Phosphotyrosine protein) phosphatases II 343-556 2.2e-77 255.7 In-house 24-284 (288) alignment
Range on Protein: 343-556
Range on HMM: 24-284/288.0
LFSGEFHDLPGPD-IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMV
..  ||..|.     .....|... ||.||||..|||||. |||| |.|....||| |||||. .......|| |||   ...|||||||..||..| |.
glleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvml

TKLKEGD----------------------------------------------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLI
||| | .                                              ... .||||.||.| ||| ||| ....||.|...|.  . .  .| .
tklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvv

IHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
.||||||||||..| .| .. . .....|||...|  .|..||.|||| ||| |.| |.||
VHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

subfamily_PTPRG_pd Subfamily PTPRG 343-449 1.1e-29 98.0 In-house 20-130 (563) alignment
Range on Protein: 343-449
Range on HMM: 20-130/563.0
LFSGEFHDLP---GPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHS-DYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTI
 || ||..|     ..  . . .||. | .|||| ||..||..||||. . .. .. || ||.||  .   ||.||.|||    .||||||.|..||..|
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

AMVTKLKEGDK
 |.|.|.|  .
vmitnlvergr

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 343-449 6e-27 89.6 In-house 24-130 (325) alignment
Range on Protein: 343-449
Range on HMM: 24-130/325.0
LFSGEFHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMV--WQenVTTIAM
 |. ||  ||  |   ..|| |  | .|||.||....| .|| ||  .| |.|||.||||. .. . . ..|.| |. |...|.||.|  |.   . . .
gfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..csvvvv

VTKLKEGDK
. .|..|..
lneldlgkd

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 344-448 4.4e-29 96.5 In-house 17-122 (281) alignment
Range on Protein: 344-448
Range on HMM: 17-122/281.0
FSGEFHDLPGPDIYPQTV-AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVT
|  |...|   ..   .. .... | .||||.||  || .|||..  ..  ..|| ||...|.....|.|||.|||  ||...||.|||...|..|.|||
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvt

KLKEGD
.  |..
reieag

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 344-448 5.5e-21 69.4 In-house 13-119 (281) alignment
Range on Protein: 344-448
Range on HMM: 13-119/281.0
FSGEFHDLPG-PDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEV-IDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMV
|  || .||| |     || .. .| ||||| ||   | .||.|.| . .   .||  | || |    . || .|||.  .  |||||.|||| |.| |.
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TKLKEGD
 .. | .
cqfletn

subfamily_PTPN6_pd Subfamily PTPN6 345-447 1.6e-27 91.3 In-house 29-135 (306) alignment
Range on Protein: 345-447
Range on HMM: 29-135/306.0
SGEFHDLP---GPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEvIDDIPHSDYFNASYIP--SFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIA
. ||..|      . . .. ..|  | .|||||||||.| .||.|.  ...| ||| ||.||   . ..||.|||.||   . . |||||||||| . | 
eeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrviv

MVTKLKEG
|.||  | 
mttkevEr

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 346-449 4.2e-24 80.1 In-house 9-112 (274) alignment
Range on Protein: 346-449
Range on HMM: 9-112/274.0
GEFHDLPGPDiyPQTVAQKEINLKKNRYKNILPYDSARVKLEVID-DIPHSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTK
 || .||     .|   .   . .|||||.||| . .|| ||  . . . |.| || ||  .|. .|||.| ||| .  ..|||||..||.|. | |.||
keflelPlnf..dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LKEGDK
||| ..
lkeane

subfamily_CG42327_pd Subfamily CG42327 346-446 3.5e-13 43.9 In-house 9-108 (319) alignment
Range on Protein: 346-446
Range on HMM: 9-108/319.0
GEFHDLPgpDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDND-KAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKL
 ||.|||   .  .. .      .|.|. |..|   .|| |. | | ... |..|||.  .|.    |||.| .   |  ||||.||. .  .|  .|.|
eefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl

KE
 |
se

0036941 (Phosphotyrosine protein) phosphatases II 347-569 9.1e-72 237.2 In-house 18-288 (297) alignment
Range on Protein: 347-569
Range on HMM: 18-288/297.0
EFHDL-PGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLeviDDiPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLK
||..| |   ... .||... ||.|||||.|||||. ||||   || ..|||.||||.. .| ....|| |||   ...|||||||..|||.| |.|.| 
efeellpllllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelv

EGDK----------------------------------------------GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--FTHPLIIH
| ..                                              ... ||||.||.| ||| ||| ...|||.||..|.  . .    .| ..|
elgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVH

CSAGVGRTGVVISIDSVVAHAK---TTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTLIPVVH
|||||||.|..| .| ..   .   ... ||....|  .|..||..||| ||| |.| |.|| |....| .|.. 
CsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk

0045098 (Phosphotyrosine protein) phosphatases II 348-560 5.9e-61 201.6 In-house 14-274 (278) alignment
Range on Protein: 348-560
Range on HMM: 14-274/278.0
FHDLPGPDIYPQTVAQKEINLKKNRYKNILPYDSARVKleviddiphsDYFNASYIPSFdnDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEG
.. |. ....  |.|... ||.|||||.|||||. |||          || |||||...  .|..|| |||    ..|||||.|....|.| |.|.|.|.
efllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

D----------------------------------------------KGDDYRTVTQFHFTEWPDKGVPKHT--SSLLKFIKEVKADHGQ----------
.                                              ...  |.||..|.. ||| ||| ..  .|.|........ . .          
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

---FTHPLIIHCSAGVGRTGVVISIDSVVAHAktTRMVDVFNFVTNIRQKRPF-MVQTQEQYAFIYGAVLEDLLW
     .| ..||||||||||... .. .  .    . ||... |. .|..||. .||..||| |.| ..|| ||.
lldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

0045450 (Phosphotyrosine protein) phosphatases II 350-556 4.6e-69 228.8 In-house 35-302 (307) alignment
Range on Protein: 350-556
Range on HMM: 35-302/307.0
DLP---GPDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDI-PHSDYFNASYI--------PSFDNDKAYIASQGPNIASMDDFWRMVWQENVTT
.|.    ..... ..|... | .|||||.|||||. |||| ..|.  ..|||.||||.        ...|.....|| |||   ...|||||.|...||.
kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtv

IAMVTKLKEG--------------------------------------------DKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--FT
| |.|.|.|                                             |. .  ||||.||.|.||| |||.....||.||.||.. ...    
ivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkg

HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
.| ..||||||||||..| .. .  . ... .   ||... |  .|..|| .||..||| |.| |.||
gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

0046845 (Phosphotyrosine protein) phosphatases II 353-564 4.7e-74 244.6 In-house 11-280 (284) alignment
Range on Protein: 353-564
Range on HMM: 11-280/284.0
GPD---IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDD-IPHSDYFNASYIPSF-----DNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTK
      ... .||... ||.|||||.|||||. |||| ..|. ...|||.||||.. .     .. |..|| |||   ...|||||||..||..| |.|.
sltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmlte

LKEGDK--------------------------------------------GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG--QFTHPLIIH
| | ..                                            .. .||||.||.|.||| ||| ....||.|...|.  .      .| ..|
lvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVH

CSAGVGRTGVVISIDSVVAHAKTTR---MVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTL
|||||||||..| .| .  . ....   .|||.. |  .|..||.|||| ||| |.| |.|| |....||
CsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 354-443 2e-27 91.4 In-house 48-137 (319) alignment
Range on Protein: 354-443
Range on HMM: 48-137/319.0
PDIYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTK
..   || |  . |  |||. |||..| ..|||| .. .  ||| |||..  . . . |||.|||   ...|||||.|. |..|| ..||
vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltk

subfamily_PTPN12_pd Subfamily PTPN12 356-449 1.4e-29 97.9 In-house 29-122 (290) alignment
Range on Protein: 356-449
Range on HMM: 29-122/290.0
IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
.|......|| | ||||||.||||| .||.|. |.. ..||| ||..|   .....|||.|||  . .||||||.|. ||. . |. .. | .|
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 356-448 2.2e-07 24.7 In-house 23-114 (332) alignment
Range on Protein: 356-448
Range on HMM: 23-114/332.0
IYPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDipHSDYFNASYIPSFDNDKAYIASQGPNIA-SMDDFWRMVWQENVTTIAMVTKLKEGD
 ||.|  .   |.  ||   .  .| .||.|   |   . |..|||..  . .  ||| .| |    .   ||||| . . . | ..  . | .
typntydkflnnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq

subfamily_PTPN1_pd Subfamily PTPN1 357-446 8.3e-20 65.7 In-house 22-107 (290) alignment
Range on Protein: 357-446
Range on HMM: 22-107/290.0
YPQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
.|...|... | ..|||... ||| .|.|||  |     || ||| .   . .. || .|||    .| ||.|||...  .. |. |. |
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

0040439 (Phosphotyrosine protein) phosphatases II 358-556 7.1e-65 214.4 In-house 2-244 (249) alignment
Range on Protein: 358-556
Range on HMM: 2-244/249.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD---------
. .||... |..||||..|||||. ||||..... ..||| |||||. ..  ...|| |||   ...|||||.|....|.| |.|.|.| .         
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

---------------------------------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ--FTHPLIIHCSAGVGRTGVVISIDS
                                 . .. |||.....| ||| |||.....||.||..|.  . .    .|...||||||||||..| .. 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

VVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
.. . .... ||... |  .|..|| .||..||| |.| |.||
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 358-449 1.6e-31 104.7 In-house 47-138 (298) alignment
Range on Protein: 358-449
Range on HMM: 47-138/298.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
 ..||.|. | ||||| .|...||.|| || .|.  .||| |||.. .... .|.||.|.|  ... ||||||..|...|| |.|.|.| ||
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldk

DSPc_SM00195 358-448 1.4e-30 101.9 In-house 17-107 (263) alignment
Range on Protein: 358-448
Range on HMM: 17-107/263.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
. | |.|. | .|||||||||||. ||||. ... ..||| ||.||   ...|.||| |||    ..|||||||.|.|..|.|.|. .| .
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng

PTPc_SM00194 358-448 1.4e-30 101.9 In-house 17-107 (263) alignment
Range on Protein: 358-448
Range on HMM: 17-107/263.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
. | |.|. | .|||||||||||. ||||. ... ..||| ||.||   ...|.||| |||    ..|||||||.|.|..|.|.|. .| .
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 358-443 3.7e-27 90.6 In-house 16-101 (284) alignment
Range on Protein: 358-443
Range on HMM: 16-101/284.0
PQTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTK
 || |  . |  |||. .||..| ..|||| .. .  ||| |||.|  . . . |||.|||   ...|||||.|. |..|| ..||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltk

0037934 (Phosphotyrosine protein) phosphatases II 359-556 4.9e-57 188.6 In-house 2-240 (243) alignment
Range on Protein: 359-556
Range on HMM: 2-240/243.0
QTVAQKEINLKKNRYKNILPYDSARVKLeviddiPHSDYFNASYIPSFDNdkaYIASQGPNIASMDD----FWRMVWQENVTTIAMVTKLKEG-------
...|... ||.||||..|||||  ||||      . |||.||..|. ...   .||.|||   . .|    ||||.|....|.| |.|.|.|        
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

---------------------------------DK-GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD----------HGQftHPLIIHCSAGVG
                                  . .| .|.|...|.. ||| ||| ....||.|..||..           ...  .|...|||||||
ywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpvlVHCsaGvg

RTGVVISIDSVVAHAkttRmVDVFNFVTNIRQKRPF-MVQTQEQYAFIYGAVLE
|||..| .. .  .    . ||... |  .|..||. .|||..|| |.| |.||
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 359-446 1.4e-22 74.8 In-house 40-127 (439) alignment
Range on Protein: 359-446
Range on HMM: 40-127/439.0
QTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
 ..| .| .  |||||.. ..| .|| |. |  .||| |.|| ||  . .|| |||.|||.  . |||||.|......|| |.|.| |
aslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve

subfamily_PTPRN_pd Subfamily PTPRN 359-448 4.5e-21 69.8 In-house 48-138 (297) alignment
Range on Protein: 359-448
Range on HMM: 48-138/297.0
QTVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
..||..| |.||||.|..|||| .||||.   .  .||| ||| |   |    ||||.|||  ... |||.|||.. |. | ..|.|.| .
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeeg

0042113 (Phosphotyrosine protein) phosphatases II 360-556 7e-62 204.3 In-house 2-241 (245) alignment
Range on Protein: 360-556
Range on HMM: 2-241/245.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD-----------
.||... | .||||..|||||. |||| ...  ..||| ||||.. ..  . .||.|||   . .|||||.|....||| |.|.. | .           
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

-------------------------------KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG-QFTHPLIIHCSAGVGRTGVVISIDSVVA
                               . | .|.|...|.. ||| ||| ....||.|...|.        .|...||||||||||..| .. .. 
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

HAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
...... |.... |  .|..|| .|||..|| |.| |.||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0049772 (Phosphotyrosine protein) phosphatases II 360-560 4.8e-36 120.5 In-house 39-282 (314) alignment
Range on Protein: 360-560
Range on HMM: 39-282/314.0
TVAQKEINLKKNRYKNILPYDsARVKLEvIDDIPHSDYFNASYIPSFdndKAYIASQGPNIASMDDF----------WRMV--WQENVTTIAM-------
.||... | .||||..|||.|  ||.|    ..  |||.||||. .|   ...||.|||.   ..||          ||||  .. || .| |       
lvadlflnrdknryldilpad.nrvilp.glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------VTKLKEG----------------DKGDDYRTV-TQFHFTEWPDKGVP--KHTSSLLKFIKEVkadhgQFTHPLIIHCSAGVGRTG-
               ..| ..                . ....     ... . .|| ..|  ..  ..|.||.|.     .  .|...||.||.|||| 
delsrLdaAlgKtpllildgngneptaadlellkeelydpelferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgt

-VVISIdsVVAHAkttRMvDVFNFVTNIRQKRP-----FMVQTQEQYAFIYGAVLEDLLW
 ||. .  .. .    .. ..   .  .|.|||      .....||| ||. |.|| | .
fvvaay..lmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 360-449 6.5e-29 95.9 In-house 2-91 (250) alignment
Range on Protein: 360-449
Range on HMM: 2-91/250.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
.||.|  |..|||| .|...||.|| ||  .   .||| |||.. ..|. ||.||.|||  |.. ||||||..|...|| |.|.||| .|
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesek

subfamily_PTPRK_pd Subfamily PTPRK 360-446 4e-27 89.9 In-house 36-122 (314) alignment
Range on Protein: 360-446
Range on HMM: 36-122/314.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
 .|.|. | .|||...||.|| .||.| .||. |.||| ||..| |. . .|.|. |||    . ||||.|..|| ..| |.|.|.|
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelve

subfamily_PTPN13_pd Subfamily PTPN13 360-449 3.3e-22 74.0 In-house 30-116 (273) alignment
Range on Protein: 360-449
Range on HMM: 30-116/273.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDiphsdYFNASYIP--SFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
.|..|. | .||||.|.|||| .||||.         | |||.|     ..   |||.|||   ...|||.|||. ... |||||. ||..|
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk

subfamily_PTPN3_pd Subfamily PTPN3 360-447 3.6e-22 73.6 In-house 34-121 (280) alignment
Range on Protein: 360-447
Range on HMM: 34-121/280.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDdipHsDYFNASY----IPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEG
..|.|  ||.||||..|||||..||||.  .     || ||.|    ||| .  . |||.|||   .. |||.|||......| |.| | | 
saarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlver

subfamily_egg_pd Subfamily egg 360-453 7.9e-14 46.0 In-house 33-126 (307) alignment
Range on Protein: 360-453
Range on HMM: 33-126/307.0
TVAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDKGDDY
| | .. ||.| | | .   ||.|||||.       |.  | ..        .| .| |   ..|||||||.||.|  | |.|  || .. . |
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 360-446 1.4e-12 42.3 In-house 34-118 (307) alignment
Range on Protein: 360-446
Range on HMM: 34-118/307.0
TVAQKEINLKKNRYKNILPYDSARVKLEVidDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
||   . | .||||...   | .|. ...  |   |||  | |.    . | .|..|||  ... .|| |. ||.| .. |. |. |
tveafsantdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvie

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 360-444 2.8e-08 27.7 In-house 30-119 (347) alignment
Range on Protein: 360-444
Range on HMM: 30-119/347.0
TVAQKEINLKKNRYKNILPYDSARVKLEV-----IDDIPHSDYFNASYIpSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKL
|... | .|.||| |.    |..|| |           .   | |||.|  ||| .| || .| |   .. |||.||   .|| .  . . 
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashi.kfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep

subfamily_PTPN9_pd Subfamily PTPN9 361-449 8e-27 89.0 In-house 36-124 (297) alignment
Range on Protein: 361-449
Range on HMM: 36-124/297.0
VAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
....  ||.||||...| ||..||.|. .|. ..||| ||...  . . ||.|| |||    ..|||||||...| .| |.|.. |  .
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergr

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 361-449 5.5e-25 82.9 In-house 14-103 (270) alignment
Range on Protein: 361-449
Range on HMM: 14-103/270.0
VAQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFD-NDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
. .   . | |||..|||   .||.|| ... ... |.|| |.. || ..|.|||..||  ... .||||.|.|.||.|.|.|.|.|  .
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 361-449 2.7e-24 80.6 In-house 27-115 (297) alignment
Range on Protein: 361-449
Range on HMM: 27-115/297.0
VAQKEINLKKNRYKNILPYDSARVKLEviDDIPHSDYFNASYI--PSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
.|...  |.||||..|| .|..||||     |. .|| || |.  |  ..|  || .|||  |..||||..|....| .|.||.||.|. .
sakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGr

subfamily_PTPN14_pd Subfamily PTPN14 361-449 4.4e-22 73.4 In-house 43-132 (300) alignment
Range on Protein: 361-449
Range on HMM: 43-132/300.0
VAQKEINLKKNRYKNILPYDSARVKLEVIDDIpHSDYFNASYIPS--FDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
.|. . | .|||.|..|||. .||.|    .  ...| ||| |      ... ||..|||    . |||.|||...|. |.|.|. .|. |
taklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

subfamily_PTPN23_pd Subfamily PTPN23 361-450 1.3e-21 71.7 In-house 37-123 (288) alignment
Range on Protein: 361-450
Range on HMM: 37-123/288.0
VAQKEINLKKNRYKNILPYDSARVKLEviddIPHSDYFNASYIPSFDND-KAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDKG
.|  ... .|||...|||||..||||.      . || |||.. .       .||.|.|   .. |||.||... . .| |... .| .| 
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkp

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 361-448 6.7e-13 42.9 In-house 50-132 (290) alignment
Range on Protein: 361-448
Range on HMM: 50-132/290.0
VAQKEINLKKNRYKNILPYDSARVkleVIDDIPHSDYFNASYIPSFdnDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
. .|. ..||||||..   | .||   ...|  . ||  | |.     .  .| .||.  ... |.|||| ||.|..| |. .| |  
ifdkntefkknrykdvvcndktrv...ilkdGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedG

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 362-449 2.3e-25 84.1 In-house 3-91 (239) alignment
Range on Protein: 362-449
Range on HMM: 3-91/239.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
|.| .|  |||| ||. || .|| || . . ||||| ||||.  .|   |||||.||   .|  |||||.|||    | |.| | || |
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 362-449 3.2e-25 83.7 In-house 2-90 (239) alignment
Range on Protein: 362-449
Range on HMM: 2-90/239.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
|.| .|  |||| ||. || .|| || . . ||||| ||||.  .|   |||||.||   .|  |||||.|||    | |.| | || |
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghk

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 362-446 4.2e-24 79.8 In-house 33-116 (287) alignment
Range on Protein: 362-446
Range on HMM: 33-116/287.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDiPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
|..  . ||||| ..||.| .|| |    .   ||| || |..|. .|.|.||.|||  |.. ||||.|...........|.  |
aeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreve

subfamily_ptpA1_pd Subfamily ptpA1 362-446 7.4e-18 59.5 In-house 42-125 (418) alignment
Range on Protein: 362-446
Range on HMM: 42-125/418.0
AQKEINLKKNRYKNILPYDSARVKLEVIDDIPHSDYFNASYIPSfDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
 .|. |  |||| |||| . .||.|. |.|   ||| || ||      | .|..|||   .. |||||||.. .  | |...  |
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsrese

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 362-448 1.8e-09 32.0 In-house 30-113 (285) alignment
Range on Protein: 362-448
Range on HMM: 30-113/285.0
AQKEINLKKNRYKNILPYDSARVKLEVIDdiphSDYFNASYIPSFDND-KAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
.  | |   ||| ..   . .|| |.  |     ||  ||..    .|  .||..|||   .. |||.|..||... . |.  | || 
tayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfegg

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 364-446 2.2e-11 37.9 In-house 52-132 (305) alignment
Range on Protein: 364-446
Range on HMM: 52-132/305.0
KEINLKKNRYKNILPYDSARVKLeviDDIPHSDYFNASYIPS-FDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
 .|.  ||||...   | . |||   |. . |||  | |.   .  .| .|..|||   ..|.|| || |..|  | |. |  |
adiaitknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktve

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 365-448 1.5e-06 22.0 In-house 94-175 (244) alignment
Range on Protein: 365-448
Range on HMM: 94-175/244.0
EINLKKNRYKNILPYDSARVKLEVidDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
  |  |||    ||.|  || |          | |||..  .     || .| |   .  |||.|. .  |  . ..  ..| |
pnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 366-441 3.2e-06 21.0 In-house 46-114 (303) alignment
Range on Protein: 366-441
Range on HMM: 46-114/303.0
INLKKNRYKNILPYDSARVKLEviddipHSDYFNASYIpSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMV
 |..|||. ...  | ..|||        | |  |||.  .| .|  | .| |   .  |||.|. ...|  . ..
knmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlll

0041856 (Phosphotyrosine protein) phosphatases II 367-566 5.1e-44 145.4 In-house 1-179 (182) alignment
Range on Protein: 367-566
Range on HMM: 1-179/182.0
NLKKNRYKNILPYDSARvkleviddipHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTkLKEGDKGDDYRTVTQFHFTEWPD
||.||||..|||||  |          ..|| ||... .   .. .|| ||| . .. ||.||......||| ..|     .  . .|...|.... |||
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpD

KGVPKhTSSLLKFIKEVKAdhgqFTHPLIIHCSAGVGRTGVVISIDSVVAHakttrMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTLIP
 |||  ...||.||.||..      .| ..||||||||||... .. .  .      |.... |  .|..|| ||.| .|| |.. |.|| ||...| ..
hgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk





Y_phosphatase Protein-tyrosine phosphatase 367-449 1.5e-28 95.2 Pfam-A 1-83 (235) alignment
Range on Protein: 367-449
Range on HMM: 1-83/235.0
NLKKNRYKNILPYDSARVKLevIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD--K
|.||||||.|||||. ||||   ..  .||| ||.|. .....|..||.|||   ...|||||||||.|..|.|.|.|.| .  |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrek

Y_phosphatase Protein-tyrosine phosphatase 367-449 1.5e-28 95.2 In-house 1-83 (235) alignment
Range on Protein: 367-449
Range on HMM: 1-83/235.0
NLKKNRYKNILPYDSARVKLevIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD--K
|.||||||.|||||. ||||   ..  .||| ||.|. .....|..||.|||   ...|||||||||.|..|.|.|.|.| .  |
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrek

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 367-449 2.1e-21 71.3 In-house 3-84 (237) alignment
Range on Protein: 367-449
Range on HMM: 3-84/237.0
NLKKNRYKNILPYDSARVKLEVIDDIphSDYFNASYIPSFDN-DKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK
|  |||| ||  || .|| |.       ||| ||.|. .||   | |||.|||  .| ||||.|||||. . | |.| | ||..
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegne

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 367-446 4.5e-15 50.0 In-house 52-130 (310) alignment
Range on Protein: 367-446
Range on HMM: 52-130/310.0
NLKKNRYKNILPYDSARVKLEvIDDIPHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
...|||| ...  |..||||. ||   . ||  | |. .    ...| ||||   .. |||||..||   .| .. |  |
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvge

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 367-446 2.9e-13 44.2 In-house 48-124 (305) alignment
Range on Protein: 367-446
Range on HMM: 48-124/305.0
NLKKNRYKNILPYDSARVKLEviDDIPHsDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
. .|||||..   |  |||||     || .|  | |. .  | | .| .| |   .  ||| | .|..| .| |. .|.|
eagknrykdvgcldnnrvkle..gpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnlle

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 367-447 5.5e-12 40.3 In-house 33-109 (267) alignment
Range on Protein: 367-447
Range on HMM: 33-109/267.0
NLKKNRYKNILPYDSARVKLEVIDdiphSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEG
| ..||. . |||| .|| |   .     .| ||||. ..   .|.|. |.|   .. ||. .. ...|..| ..||  ..
nqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 367-446 8.7e-10 33.1 In-house 43-118 (288) alignment
Range on Protein: 367-446
Range on HMM: 43-118/288.0
NLKKNRYKNILPYDSARVKLEviDDiPHSdYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
|  ..||.|.   | .||||.  || |.  | .|  ..|  ...  | .| |  . .. .|.|. ...|  | |...| |
nptrdryenlprcditrvkls..dd.pdf.yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcelle

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 367-446 2.4e-07 24.5 In-house 51-129 (302) alignment
Range on Protein: 367-446
Range on HMM: 51-129/302.0
NLKKNRYKNILPYDSARVKLEVIDDiphsDYFNASYI--PSFDndKAYIASQGPNIASM---DDFWRMVWQENVTTIAMVTKLKE
|||||. ...  .|| .||||   |    .| ||| .  |..   .  | .| |.  |    ..|||||.||..... .. . .|
nlkknqsedvpildsnlvkleaepd....syvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeee

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 369-448 3.2e-16 54.0 In-house 49-142 (350) alignment
Range on Protein: 369-448
Range on HMM: 49-142/350.0
KKNRYKNILPYDSARVKLE----VIDDIPH----SDYFNASYIP------SFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGD
 ||||||||||. .||||.      | . |    .|| ||.|.       . . |  ||| |.|    .|||.... . .|. | ..|.. | .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 369-443 6.3e-10 32.9 In-house 50-140 (349) alignment
Range on Protein: 369-443
Range on HMM: 50-140/349.0
KKNRYKNILPYDSARVKLEVIDD--------------IPHSDYFNASYI--PSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTK
 |||||.||||. .||||.                      || || |.  . .. .| ||| | |  ...|||....  ..|  .  ...
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnd

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 369-446 2.8e-09 31.1 In-house 52-126 (301) alignment
Range on Protein: 369-446
Range on HMM: 52-126/301.0
KKNRYKNIlPYDSaRVKLEVIDDIPHSDyFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKE
.|.||... | .     .|||.|        | .||.  . . .||.|||  ....||| |. | .| .|.|...  |
dkhryptv.PckP.stavevivdGkrvP.ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkve

0044763 (Phosphotyrosine protein) phosphatases II 378-553 6.1e-30 99.6 In-house 1-166 (178) alignment
Range on Protein: 378-553
Range on HMM: 1-166/178.0
PYDSARVKLEVIDDIPHSDYFNASYIPSFdndkAYIASQGPniasmDDFWRMVWQENVTTIAMVTKLKEGDKGDDYRTV-----TQFHFTEWPDKGVPKH
|.|  ||.|. . ... |||.|||.|  .     |..|..|      |..........|.| ..|. .|. . ....        |.... .|| |||  
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdl

TSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHakttRMvDVFNFVTNIRQKRPfMVQTQEQYAFIYGA
.. .|.|.. ... . .  .| ..||||||||.|... .. .  .    .. .... .  .|..|| .|....|. ..|  
lehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyef

0046846 (Phosphotyrosine protein) phosphatases II 389-554 5.2e-33 109.6 In-house 6-169 (176) alignment
Range on Protein: 389-554
Range on HMM: 6-169/176.0
IDDIPHSDYFNASYIPSFdndkAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDK-------GDDYRTVTQFHFTEWPDKGVPKHtSSLLKFIK
. . ...|| ||..| .     ..|| |||   .. ||..|......|.. ..|...| ..        . ..   |.... ||| ||| . . ||....
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllelle

EVKADHGQFtHPLIIHCSAGVGRTGVVISIDsvvaHAKTTRMVDVFNFVTNIRQKRP-FMVQTQEQYAFIYGAV
...    .  .| ..|||||.||||... ..      .. . ..|.. .  .|..|| ..|||.||| |.| ..
firealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefe

0051429 (Phosphotyrosine protein) phosphatases II 392-557 7.6e-40 132.6 In-house 1-224 (272) alignment
Range on Protein: 392-557
Range on HMM: 1-224/272.0
IPHSDYFNASYIPSFDN---DKAYIASQGPNIASMDDFWRMvWQENVTTIAMVTKLKEGD----------------------------------------
.| |.|.||.... . .   ......|.||  .. .||||. ......|| ..... | .                                        
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

---------------KGDDYRTVTQFHFTEWPDKGVPKHTssLLKFIKEVKAdhgqfTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVD--------
               . ...|.|...|.| ||| |||...  ||...... .      .|...|||||..|||.|. .. ...    . .||        
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VFNFVTNIRQKRPFMVQTQEQYAFIYGAVLED
....|  .|..|| .|||.|||.|.| |.|| 
leeaveelraqrpgavqteeqylflyeallel

0043147 (Phosphotyrosine protein) phosphatases II 393-551 5.3e-38 125.8 In-house 3-154 (172) alignment
Range on Protein: 393-551
Range on HMM: 3-154/172.0
PHSDYFNASYIPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLkEGDKGDDYRTVTQFHFTEWPDKGVPkHTSSLLKFIKEVKA-DHGQFT
..||| ||||..     . .|| |||    ..|||||......|.| ..|.| . |. . .|.. |.... ||| ||| ... ||.|.. ..   . .  
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspg

HPLIIHCSAGVGRTGVVISIDSVVahakttRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
.| ..||||||||||... .. .       . ..... |  .|.||| .||...|| |.|
gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfly

0051082 (Phosphotyrosine protein) phosphatases II 393-554 3.4e-32 106.5 In-house 1-149 (151) alignment
Range on Protein: 393-554
Range on HMM: 1-149/151.0
PHSDYFNASYIPSFdndkaYIASQGPniasMDDFWRMVWQENVTTIAMVTKLKEGDKGDDY-----RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAdh
|.|||.|.||. ..     ...|.||    ..||..........|| ......| ..  .|     ..|...... ||| |.| .. ..|.|.... .  
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld..

gQFTHPLIIHCSAGVGRTGVVISIDSVVAHakttrmVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAV
 .  .|...|||||.||||... .. .  .      |...  .  .|.||| .||. .|. |.. |.
.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfal

0036282 (Phosphotyrosine protein) phosphatases II 395-551 8e-40 131.7 In-house 2-163 (174) alignment
Range on Protein: 395-551
Range on HMM: 2-163/174.0
SDYFNASYIPSFDNDKAYIASQGPNIasmddFWRMVWQENVTTIAMVTKLKEGD-----------KGDDYRTVTQFHFTEWPDKGVPKHTSsLLKFIKEV
|||.|||..  .   . .||.|||       ||.|......||. |....|| .           . | .|.. |.... ||| |||  .  ||.|.|.|
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfv

KADHGQ-FTHPLIIHCSAGVGRTGVVISIDSVVAHAKtTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
.  . .   .|...||||||||||... .. .  . . ...||....|  .|..|| ||||..|| |.|
eealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

0049260 (Phosphotyrosine protein) phosphatases II 403-551 8.2e-33 108.6 In-house 2-143 (152) alignment
Range on Protein: 403-551
Range on HMM: 2-143/152.0
IPSFDNDKAYIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDKGDDYRTVtQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGV
|. . . ...|| |||   ...|||||... ..||| |.|.| | .|   ..   |.... ||| |||...  || ... ..    .  .| ..||||||
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGv

GRTGVVISIDSVVahakttRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
||||... .. .       . |.....|  .|.||| .|....|. |.|
gRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

0038934 (Phosphotyrosine protein) phosphatases II 412-550 4.8e-08 28.4 In-house 20-169 (194) alignment
Range on Protein: 412-550
Range on HMM: 20-169/194.0
YIASQGPNIASMDDFWRMVWQENVTTIAMVTKLKEGDKGDDYRT---------------VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF-THPLI
 ||  .|   |.|...  ... .....  . ||.  . |  ..                  ...   .||.|..  .. ||.|.. |.  . .   .   
fiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvva

IHCSAGVGRTGVVIsidsvVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
.|| ||.||||...     .|.   ..  ..   .  .|.||| ....|...  .
VHCkaGlgRtGtlv.....aaYLiyrlgmsaeeAialfrekRpgaipnqdyleal

0048076 (Phosphotyrosine protein) phosphatases II 427-554 6.1e-23 76.5 In-house 22-139 (145) alignment
Range on Protein: 427-554
Range on HMM: 22-139/145.0
WRMVWQENVTTIAMVTKLKEGDKgddyRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFtHPLIIHCSAGVGRTGVVISIDSVVAhakttRMVDV
... .. ..||.  .|  .|. .    |...|.... ||| |||  .. ||.|.. ... . .  .| ..||||||||||... .. .       . |..
lellkdlgittvlnltselelle....rlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsl

FNFVTNIRQKRPFMVQTQEQYAFIYGAV
.. .  .|..||..|....|. |.| ..
eealelvrsqrpgavpnpgqlrflyefe

PTEN_1 428-510 5e-06 21.5 In-house 58-149 (196) alignment
Range on Protein: 428-510
Range on HMM: 58-149/196.0
RMVWQENVTTIAMVTKLKEGDKG----DDYRTVTQFHFT----EWPDKGVPKhTSSLLKFIKEVKADHGQ--FTHPLIIHCSAGVGRTGVVIS
... .     | .|  | |...     .| ..  . ...    ...| |.|   |.|....|...    .    .  ..|| ||.||.|.|. 
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

0048179 (Phosphotyrosine protein) phosphatases II 429-551 9.8e-22 72.7 In-house 24-138 (144) alignment
Range on Protein: 429-551
Range on HMM: 24-138/144.0
MVWQENVTTIAMVTKlkEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFtHPLIIHCSAGVGRTGVVISIDSVVahakTTRmVDVFN
. .. ..||.  .|   | .. .  |...|.... ||| ||| ... ||.|.. ... . .  .| ..||||||||||... .. ..    . . .....
llkklgittvinlte..eyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lslee

FVTNIRQKRPFMVQTQEQYAFIY
 .  .|..||..|....|. |..
alalvrsrrpgavpnpgqlrfLl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 441-561 9.9e-19 62.4 In-house 158-274 (288) alignment
Range on Protein: 441-561
Range on HMM: 158-274/288.0
VTKLKEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVkadhGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFM
|. |.   .|..   | . |. ||.|.|||.   | |.... .     ....|...|.|||||||| .| |  ..  .. .  . . ..... |..|   
vsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfka

VQTQEQYAFIYGAVLEDLLWR
.||. || ...  |||.|| .
iqtemqylyvhrcvleelllk

subfamily_PTPRG_pd Subfamily PTPRG 442-562 2.1e-35 117.0 In-house 171-291 (563) alignment
Range on Protein: 442-562
Range on HMM: 171-291/563.0
TKLKEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMV
.|||.... |. ..|.|.|.|.|||.|||.|.   |.|.|  .| . . . |...||||||||||. | .|...   ..  .|.||.|.  || .|.|.|
lklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflv

QTQEQYAFIYGAVLEDLLWRN
||.||| |.. |.|| .. ..
qteEqYiflhdalleaiaske

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 443-559 2.5e-17 57.5 In-house 177-290 (305) alignment
Range on Protein: 443-559
Range on HMM: 177-290/305.0
KLKEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSVVAH-AKTTRMVDVFNFVTNIRQKRPFMV
 |.    ||.  .| ....|||||.|||    . |...  ..  .     |...|||||.|||| ...|. .. . |.  .   . ..|  .|..| | .
llnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsi

QTQEQYAFIYGAVLEDLL
|.. || ||.  .|. .|
qndvqylfihrvmlnyfl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 444-593 8.3e-33 108.9 In-house 169-323 (325) alignment
Range on Protein: 444-593
Range on HMM: 169-323/325.0
LKEGDKGdDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTH------PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKR
.|. .|| . |.| ||..  |.| ||.|. ..|. ... ||| . . |       |...||||||||||| ||. |..|.  .   ||.|.|| ..|..|
vkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdr

PFMVQTQEQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEF
| ||.| .|| .|| |. | ..  || .||  |  .|  |.       . .. |||
psmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqklniekef

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 445-572 5.6e-30 99.1 In-house 165-293 (439) alignment
Range on Protein: 445-572
Range on HMM: 165-293/439.0
KEGDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVK-ADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQT
.| |...  ||| |||.. |||| || ..| .|.|.. .. |.  . . |...|||||||||| .|..|  . . |.   ||.   |. .|..|  |||.
nerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqa

QEQYAFIYGAVLEDLLWRNTLIPVVHFTD
  || ||| |||||. . .. . . .|  
lcqyvfiynavledivyGdiavtidefkk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 445-557 1e-26 88.5 In-house 169-282 (290) alignment
Range on Protein: 445-557
Range on HMM: 169-282/290.0
KEGDKGDDYRTVTQFHFTEWPDKG-VPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQT
|. ..... ..|||...| |...| |......|| . . .|  . .  .....|||..|||..| ....  . ..||.  .|||. . . |...| .|||
knknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqt

QEQYAFIYGAVLED
..|| .|.  ||. 
vqqyqgifqivlty

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 447-579 9.4e-36 118.7 In-house 178-312 (319) alignment
Range on Protein: 447-579
Range on HMM: 178-312/319.0
GDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQ
  |  | | .|||||  |||.|||...| |....| |.  . .    .....||||||||||| | .| ..   |  ..|||.||| ..||.|. .||  
dgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

EQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLHS
 || ||| |.||. |. .. . .  |  .|..| .
vqykfiysalleehlfghsdvampdfpayleelsn

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 447-578 4.5e-35 116.5 In-house 142-275 (284) alignment
Range on Protein: 447-578
Range on HMM: 142-275/284.0
GDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQ
  |  | |...||||  |||.|||...| |....| |.  . .    .....||||||||||| | .| ..   |  ..|||.||| ..||.|. .||  
dgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

EQYAFIYGAVLEDLLWRNTLIPVVHFTDHLQDLH
 || ||| |.||. |. .. . .  |  .|..| 
vqykfiysalleehlfghsdvalpdfpayleels

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 447-559 2e-20 68.1 In-house 169-278 (307) alignment
Range on Protein: 447-559
Range on HMM: 169-278/307.0
GDKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLIIHCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPFMVQTQE
 | ... ||.... ...|||.|||.   . . ... |. |    | |...||||||||.| ...|  |     .     |. ..| ..|..|.. .||. 
vdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqtea

QYAFIYGAVLEDLL
|| ...  .|| .|
qylylhrvlleyfl

subfamily_PTPN6_pd Subfamily PTPN6 448-555 1.2e-31 104.8 In-house 180-294 (306) alignment
Range on Protein: 448-555
Range on HMM: 180-294/306.0
DKGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFT----HPLIIHCSAGVGRTGVVISIDSVVAHAKT---TRMVDVFNFVTNIRQKRPFM
.|... |.| |.||..|||.||||... .|.|...|.. . ...     |...|||||.|||| .| || ..   ..      .|. ..|  .|. |  .
kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsgl

VQTQEQYAFIYGAVL
|||..|| |.| |. 
vqteqqykfvykaik

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 449-735 1.6e-181 598.9 In-house 167-453 (515) alignment
Range on Protein: 449-735
Range on HMM: 167-453/515.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYA
||||.|||||||||||||||||||||||||.||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||..||||||||
kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqya

FIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYM
|||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||| ||.|||||||||||.|||||||| |||||||| |
fiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvildspdhdyinasqm

KGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKA
||.||||.|||||||||||||||||.. ||||||||||| |.|||||||||. .| .||||||| ||||||||.| |||.|||||| 
kgihctfmttqmplpttvsdfwsmvlnnkpstivmlndksqndkscaqywpdansvqfgsysvstlstssdgdmtirqlqvtrnskr

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 449-596 4.3e-86 283.6 In-house 168-315 (315) alignment
Range on Protein: 449-596
Range on HMM: 168-315/315.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYA
|....||||||.|||||||||.|.||||||.|||||||.|. ...|..||||||||||||||||.|||..| ||.|||||||.|.|.|||..|||.|.||
kseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeya

FIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTL
|||.|||||||||||||.|.||||||||||.|.||.|||||||||.||
fiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefetl

subfamily_Ptp69D_pd Subfamily Ptp69D 449-577 2.9e-37 123.5 In-house 177-305 (307) alignment
Range on Protein: 449-577
Range on HMM: 177-305/307.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYA
. .| | |.|.|.|.|.|  ||... .|||.|..|.  . .   |...||||||||.|.....||.. . |.   ||.|..| ..|..|...||  ||| 
evedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYv

FIYGAVLEDLLWRNTLIPVVHFTDHLQDL
|.| |.|.   . .| . | .. |... |
flyralldyssygdtdedvddledaierl

subfamily_PTPRB_pd Subfamily PTPRB 449-556 4.6e-37 122.6 In-house 174-283 (293) alignment
Range on Protein: 449-556
Range on HMM: 174-283/293.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH--GQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQ
|... |.|.|.||| ||| |||..|..||.|...|.  .   . ..|...||||||||||. |..| .. . ... .||.| .|...|..| ..|||..|
kekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekq

YAFIYGAVLE
| ||. .||.
Yifihqcvld

subfamily_PTPN1_pd Subfamily PTPN1 449-557 2.5e-23 77.2 In-house 157-270 (290) alignment
Range on Protein: 449-557
Range on HMM: 157-270/290.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhGQF---THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPFMVQ
| .. |....||.| ||| |||.  ...|||. .|.   | .     | .||||||.||.| .. .|..... . .     ||. . . ..|. |  ..|
ktqetreilhfhyttwpdfgvpespaaflkflfkvres.GslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq

TQEQYAFIYGAVLED
|..|  | | |.|| 
tadqlrfsylaileG

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 449-556 1.6e-19 64.8 In-house 181-285 (305) alignment
Range on Protein: 449-556
Range on HMM: 181-285/305.0
KGDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDV-FNFVTNIRQKRPFMVQTQEQY
 | . | ||..|. .|||.|||    ..|..... .. .|    |...|||||.|||| |. .. ..    . ....     .  ||..|   .||..||
pgekarkvthyhwidwpdrgvpaadlailellekarpskg....pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqy

AFIYGAVLE
 |..  .|.
lfvhqviln

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 450-596 5.3e-44 145.6 In-house 171-318 (318) alignment
Range on Protein: 450-596
Range on HMM: 171-318/318.0
GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADH-GQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYA
 .. |.| |.|.|.|||.|||....|||.....|.. .  . ..|...||||||||||| | .|... ..|   .||||..|...|..|. ||||..|| 
eeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqye

FIYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTL
||| ..|| |   .| .   ........|. .    |...|  ||| |
fiydvllealasgdtevdasdlrsrirelreqdpesgttemdaefqrl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 450-577 2.1e-35 117.2 In-house 171-298 (315) alignment
Range on Protein: 450-577
Range on HMM: 171-298/315.0
GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
||. |.| |.|.| ||| ||||.| .|...|. ||  | .   ....||||||||||  |..|.|. .|.. ...||.||.|..||.|  |||. ||| |
gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqf

IYGAVLEDLLWRNTLIPVVHFTDHLQDL
|| |.|| ..  .| |    . .. . |
iydalletfvcgdtsiaqdlylqrydsl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 450-558 2.4e-35 117.0 In-house 166-276 (281) alignment
Range on Protein: 450-558
Range on HMM: 166-276/281.0
GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHG-QFTHPLIIHCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPFMVQTQEQY
. . |.|.|...| |||.|||. |. ||.| |||.  .  .  .||.|||||||||||. |..| .| .. ......|| . |...|..| .||||  ||
sgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy

AFIYGAVLEDL
.|.| |||. |
efvykavldal

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 450-559 4.1e-27 89.9 In-house 169-279 (287) alignment
Range on Protein: 450-559
Range on HMM: 169-279/287.0
GDDYRTVTQFHFTEWPDKG-VPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYA
 .| ..|.|...|.|...| |... ..|| . . .|... .   ....|||..|||... ....  . ..||   .|||. . . |...| .||| ||| 
agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqyk

FIYGAVLEDLL
||. .||| | 
findivleyld

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 450-555 4e-17 56.9 In-house 164-274 (287) alignment
Range on Protein: 450-555
Range on HMM: 164-274/287.0
GDDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV-----KADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQ
. . | | |... .||||...  . .|..|. .|      |  .. . ||..|...|.||.|.....  .|   . .  ||| . |  .|..|  .||. 
trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqav

EQYAFIYGAVL
 |. ..| |. 
vqlrllyealv

subfamily_PTPRD_pd Subfamily PTPRD 451-636 8.5e-64 211.1 In-house 174-358 (564) alignment
Range on Protein: 451-636
Range on HMM: 174-358/564.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
.. |.|.|||||.|||.|||... |||..|..|.| . . ..|...||||||||||. | ||...  .|. ..||....|...|..|..||||.|||.||
sesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFi

YGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDpPASQTRSGRTPDNQPKNRYGNNLPLERNRVILD
. |.|| |   || ... ....||| |..  .. . ... .||| |..  .. ....  ..  | |. |||. | |.||..||.|.
heailealacgntevesenlkqhlqkLaeveedtemtgleleFqrLatakei.eleefavatkpknkkknrfsnilalescrvvls

subfamily_PTPRA_pd Subfamily PTPRA 451-592 9e-44 144.7 In-house 188-329 (330) alignment
Range on Protein: 451-592
Range on HMM: 188-329/330.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
.. | |.||||| ||| ||| ..  .||..|.||. . | . |...||||||||||  | .|.|..  |. |.||||.|| ..|..|| ||||.||| ||
kksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi

YGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKE
| ..||  |. .| . |. .  ||| |...  |  .  . .|
ykvlleyylygdteldvsslekhlqklynkitgtdkigleee

subfamily_PTPRK_pd Subfamily PTPRK 451-595 3.8e-40 132.6 In-house 170-314 (314) alignment
Range on Protein: 451-595
Range on HMM: 170-314/314.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
...|.| ||.|. ||| .||..  .|||....||. . .   ....||||| ||||. | ||.|.  ... ..||||| | ..|.... ||.|.||| ||
eeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfi

YGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQT
| ..||  |  .| ||| .|     .          |.. .||||
ydvileaclcgetaipvsefkalylesirldpqtnssqlkeefqt

subfamily_PTPN12_pd Subfamily PTPN12 451-556 1.5e-36 120.8 In-house 167-275 (290) alignment
Range on Protein: 451-556
Range on HMM: 167-275/290.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRM---VDVFNFVTNIRQKRPFMVQTQEQY
.. |.|.|||.|.|||.|||. ..|||..|..|.  . .  .||..||||||||||..|.|| |    |. ..   .|||. |...|..|. .|||.|||
kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqy

AFIYGAVLE
 ..| ||.|
elvykavae

DSPc_SM00195 451-556 6.9e-36 119.3 In-house 155-260 (263) alignment
Range on Protein: 451-556
Range on HMM: 155-260/263.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
.. |.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||....||... . ... .||.|. |...|..|| ||||.|||.||
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

YGAVLE
| |.||
yeaile

PTPc_SM00194 451-556 6.9e-36 119.3 In-house 155-260 (263) alignment
Range on Protein: 451-556
Range on HMM: 155-260/263.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
.. |.|||.....|||.|||..|.|.|.....|| .. . ..|...||||||||||....||... . ... .||.|. |...|..|| ||||.|||.||
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

YGAVLE
| |.||
yeaile

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 451-555 3e-35 116.7 In-house 172-276 (288) alignment
Range on Protein: 451-555
Range on HMM: 172-276/288.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
 . ...||.... |||.|||. .  ||.... ||  . . | |.|.||||||||||. |..| .. . ... ..||...|...|..|...|||..|| ||
kteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi

YGAVL
| ..|
yevll

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 451-594 3.7e-34 112.8 In-house 86-230 (440) alignment
Range on Protein: 451-594
Range on HMM: 86-230/440.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
 . ||. |.|.  |||||||| .. .||.|..|.  . .    ||..|||||.|||||.|..||.. .|| .  .|.|.|. ..|..|| |||| |||||
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

IYGAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQ
.. |||| ||  .|||     |.......       .| . .||.
vheavlegllcgdtliledditerveqiqwpnphtdksplqqefe

subfamily_PTPN9_pd Subfamily PTPN9 451-556 1.2e-27 91.7 In-house 170-288 (297) alignment
Range on Protein: 451-556
Range on HMM: 170-288/297.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFT-------------HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKR
.. |.|| | |. ||| |||. ..|||.....|.   ....              |...|||||.||||  |..|  ... ... .|||.. |  .|..|
eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqr

PFMVQTQEQYAFIYGAVLE
 |..||.|||.| | ||||
afsiqtpeqyefcylavle

subfamily_PTPRN_pd Subfamily PTPRN 451-557 2e-27 90.7 In-house 184-291 (297) alignment
Range on Protein: 451-557
Range on HMM: 184-291/297.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAH-AKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
.. ||||||||  ||..|||  . |||.| . |   .   . |...|||.|.||||| | || |... .|  . .|.   .  .|..|| .|.|..|. |
setrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef

IYGAVLED
...|| |.
altavaee

subfamily_PTPN23_pd Subfamily PTPN23 451-557 2.1e-26 87.4 In-house 168-279 (288) alignment
Range on Protein: 451-557
Range on HMM: 168-279/288.0
DDYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKA----DHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHA-KTTRMVDVFNFVTNIRQKRPFMVQTQE
|  ..|.  ..|.||. |||.  ..||.|..||..     . .   ||..|||||||||||.  . ..|.   |   ..|. . |  .|..| ||||..|
davksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqeke

QYAFIYGAVLED
|. | | |||| 
qlkfsyeavlea

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 452-578 3e-40 133.3 In-house 176-303 (305) alignment
Range on Protein: 452-578
Range on HMM: 176-303/305.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTH-PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
. |||.|...|.|||.|||. ..|||..||.|. |. .    ||..||||||||||| |..|  . ..|.  .||||. . ..|.||. ||||..|| |.
esrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvfl

YGAVLEDLLWRNTLIPVVHFTDHLQDLH
. |. | .   .| | .  .. ... |.
hdaldelitcgdtsiigsnlrarvnklk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 452-563 5.3e-39 129.2 In-house 183-295 (298) alignment
Range on Protein: 452-563
Range on HMM: 183-295/298.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFT-HPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
. |.| |.|||.|||||||....|.|.....|.| . |   .|.|..|||||||.|  | ||||. ..|. ..||||. |  .|.||| .|||.|||.||
kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfi

YGAVLEDLLWRNT
| |||| |   |.
yeavlealdsfnd

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 452-558 1.9e-38 127.1 In-house 135-242 (250) alignment
Range on Protein: 452-558
Range on HMM: 135-242/250.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQ-FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI
| |.| |.||. |||||||... . |...|.|.| . |  . |.|..|||||||.|  | ||.|. ..|. ..||||...  .|..|| .|...||| |.
derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfv

YGAVLEDL
| ..|. |
yeiilkal

Y_phosphatase Protein-tyrosine phosphatase 452-556 1e-35 118.6 Pfam-A 131-235 (235) alignment
Range on Protein: 452-556
Range on HMM: 131-235/235.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
. |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.....| .. ...... |||...| ..|..|| |||. |||.|.|
ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly

GAVLE
 |.||
kaile

Y_phosphatase Protein-tyrosine phosphatase 452-556 1e-35 118.6 In-house 131-235 (235) alignment
Range on Protein: 452-556
Range on HMM: 131-235/235.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
. |.|.|.|.|.|||.|||....|||..|..|. .. . ..|...||||||||||.....| .. ...... |||...| ..|..|| |||. |||.|.|
ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly

GAVLE
 |.||
kaile

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 452-556 5.4e-32 105.9 In-house 131-237 (237) alignment
Range on Protein: 452-556
Range on HMM: 131-237/237.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEV--KADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
. | . |..|| |||.|||..|..||.| |..  .. | . . | ||||||||||||... ||... .||  ..||..|.| .| . ||...||..|| |
evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvf

IYGAVLE
|. ..||
ihqtile

subfamily_PTPN13_pd Subfamily PTPN13 452-558 3e-29 97.1 In-house 164-269 (273) alignment
Range on Protein: 452-558
Range on HMM: 164-269/273.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
. | |....|..||| |||... .||.|..||.  .   . |...|||||.||.|..|.|| |.   .  . .|| . | ..|..|  .|||..|| |.|
esrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvy

GAVLEDL
 |.|| |
kailevl

subfamily_PTPN3_pd Subfamily PTPN3 452-556 9.7e-29 95.2 In-house 169-273 (280) alignment
Range on Protein: 452-556
Range on HMM: 169-273/280.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
. |...|. ...|||.|||......|.|...|.. .   ..|...|||||.|||||.| ..  .|   ... | . . | ..|..|  .|||..|| |. 
eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvC

GAVLE
 |.|.
eailk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 452-556 1.5e-28 94.5 In-house 150-262 (270) alignment
Range on Protein: 452-556
Range on HMM: 150-262/270.0
DYRTVTQFHFTEWPDKGVPKHTS------SLLKFIKEVKADHGQFTH--PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQT
. | .. |....|||.|||...       .||| ...|.. . .. .  ||..||||||||||..| .| .|   ..|. ||| . ....|..|. .||.
eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqh

QEQYAFIYGAVLE
 |||.|.| ||.|
peqyeflykavve

subfamily_CG7180_pd Subfamily CG7180 452-559 7.6e-26 85.4 In-house 178-291 (296) alignment
Range on Protein: 452-559
Range on HMM: 178-291/296.0
DYRTVTQFHFTEWPD-KGVPKHTSSLLKFIKEVKADHGQF-----THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQE
. |.|..|..|||.  . ||  |..|..... |.   ..      . |.....| |..|.|| ..||  .  .. .  ||||..|  .|..|| .|.. |
etRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenve

QYAFIYGAVLEDLL
.| .||  .|| .|
eYkyiYdvlleavl

subfamily_PTPN14_pd Subfamily PTPN14 452-556 7.6e-24 79.2 In-house 181-294 (300) alignment
Range on Protein: 452-556
Range on HMM: 181-294/300.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF---------THPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQ
..|||  . .|.|||.|||.  .. |....||..   ..           |...|||||||||||.|  | ..|  .. . .|. . .. .|..| ..||
eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvq

TQEQYAFIYGAVLE
|  || |.| ....
tlaqYkfvYkvlik

subfamily_ptpA1_pd Subfamily ptpA1 452-510 1.5e-08 28.8 In-house 184-248 (418) alignment
Range on Protein: 452-510
Range on HMM: 184-248/418.0
DYRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF------THPLIIHCSAGVGRTGVVIS
. | .||...  |||. .| ||  . .... .   . |         |.|.|||||||||| . .
etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 452-559 7.5e-06 19.8 In-house 168-280 (303) alignment
Range on Protein: 452-559
Range on HMM: 168-280/303.0
DYRTV-TQFHFTEWPDKGVPKH-TSSLLKFIKEVKADHGQFT--HPLIIHCSAGVGRTGVVISIDSV--VAHAkTTRMVDVFNFVTNIRQKRPFMVQTQE
||..     |. .|| . .| . .. ..| | ....   ...  .| .    .|.||.|    ...     |.     .|. . . |.|. |   ||   
dyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhs.eqasldlvkclenvrngrlhavqnls

QYAFIYGAVLEDLL
|....|  . | .|
qfsvvytllaehvl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 453-571 4.1e-47 155.7 In-house 176-297 (297) alignment
Range on Protein: 453-571
Range on HMM: 176-297/297.0
YRTVTQFHFTEWPDKGVPK--HTSSLLKFIKEVKADHGQFTH-PLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
 | | |..|.||||| |..  ..|||||.|.||. |..| .. ||..||.||||||||...||||||.|| .  ||.|..|. .||.||..|||.|||.|
rrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykf

IYGAVLEDLLWRNTLIPVVHFT
.| |||| ||  .| |.. .|.
vyvavleallsedtriqasyfe

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 453-594 7e-41 135.3 In-house 177-319 (319) alignment
Range on Protein: 453-594
Range on HMM: 177-319/319.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAD-HGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
 |.|..|..|||||..||... |||...|...   ...   |...||||||||||  | .| .. . |   ..|||..| ..| .|..|||..||| |||
tRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiy

GAVLEDLLWRNTLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQ
 |.|| .   .| | | .. | |..| .   . | ... .|||
ealleaveagdteievqdlrdrlkqlaekvadtgetglerefq

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 453-556 1.2e-32 108.0 In-house 135-238 (239) alignment
Range on Protein: 453-556
Range on HMM: 135-238/239.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYG
 | | |.||| |||||||......| . ...  |    ..| .||||||||||| .. ||... .||  . ||.||.|  ||. ||.|||| ||| ||. 
eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

AVLE
||||
avle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 453-556 1.8e-32 107.4 In-house 136-239 (239) alignment
Range on Protein: 453-556
Range on HMM: 136-239/239.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYG
 | | |.||| |||||||......| . ...  |    ..| .||||||||||| .. ||... .||  . ||.||.|  ||. ||.|||| ||| ||. 
eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

AVLE
||||
avle

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 453-555 2.1e-29 97.5 In-house 160-265 (274) alignment
Range on Protein: 453-555
Range on HMM: 160-265/274.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHP---LIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAF
 |.|. . .|.|||. .|.....||....||. .. . ...    ..|||||.||||. |.|.  | . . . .|||.. |.|.|..|  ||||.||| .
ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyel

IYGAVL
|. |. 
ihralc

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 453-553 5.2e-14 46.7 In-house 180-277 (301) alignment
Range on Protein: 453-553
Range on HMM: 180-277/301.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFI-Y
 |||| . ..||.|.||||    | .... ||  .    .|...|||||.||.   |. . .  . .. . ... . . ..|..|   |||..|  ..  
trtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtl

GA
|.
Gt

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 453-555 1.4e-13 45.2 In-house 166-266 (281) alignment
Range on Protein: 453-555
Range on HMM: 166-266/281.0
YRTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLIIHCSAGVGRTGVVISIDSVVAHAKT-TRMVDVFNFVTNIRQ-KRPFMVQTQEQYAFI
 | .|.. . ||||  ||. .  .|| .....|     . | .|||||||||.| .....  .   ..   . |. . |. .|   |   ||| .|| .|
trlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymli

YGAVL
.  .|
wkvll

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 454-557 3.4e-23 76.8 In-house 188-292 (301) alignment
Range on Protein: 454-557
Range on HMM: 188-292/301.0
RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVK-ADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYG
..|.|.. |.||. || .     |. | .|  . .     |...|||..|.|.|| .|..  .  .|    ||||. .  .|...| .|.| ||| .|| 
wdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiyd

AVLED
.. . 
vidmy

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 454-557 2.2e-15 50.9 In-house 188-287 (302) alignment
Range on Protein: 454-557
Range on HMM: 188-287/302.0
RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKAdhgqFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGA
.||  ..|. |||.| ||.. . |. .|  ..    . . ...|||||||||| ...|   .   .. .. |. . |. .|| |   ||...|  ..   
ktvdilafsawpdhGapkeaytaldilkfces....ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllc

VLED
|   
vtkg

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 454-551 3.8e-11 37.5 In-house 95-197 (199) alignment
Range on Protein: 454-551
Range on HMM: 95-197/199.0
RTVTQFHFTEWPDKGVPKHTsSLLKF---IKEVKADHGQF-THPLIIHCSAGVGRTGVVISIDSVV-AHAK-TTRMVDVFNFVTNIRQKRPFMVQTQEQY
| .... || | .|  |. .  .. |    .||   . |    |.|.||| | | ||| ...|  | .| .  | .||.|.    .|| |  .. . ..|
reishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

AFIY
 |||
nfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 454-551 3.8e-11 37.6 In-house 94-196 (198) alignment
Range on Protein: 454-551
Range on HMM: 94-196/198.0
RTVTQFHFTEWPDKGVPKHTsSLLKF---IKEVKADHGQF-THPLIIHCSAGVGRTGVVISIDSVV-AHAK-TTRMVDVFNFVTNIRQKRPFMVQTQEQY
| .... || | .|  |. .  .. |    .||   . |    |.|.||| | | ||| ...|  | .| .  | .||.|.    .|| |  .. . ..|
reishyqftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

AFIY
 |||
nfiy

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 454-565 3.4e-10 34.5 In-house 158-257 (290) alignment
Range on Protein: 454-565
Range on HMM: 158-257/290.0
RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqfTHPLIIHCSAGVGRTGVVISIDSVVAH-AKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYG
 |||   . .| .  |...| .||. |. |||     . | |.||  |. |  .. .|.      |.|.  | . . . ..|..|  ........||.  
ftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvda

AVLedllwrntlI
...         .
giv.........l

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 454-558 2.3e-09 31.7 In-house 116-221 (255) alignment
Range on Protein: 454-558
Range on HMM: 116-221/255.0
RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqftHPLIIHCSAGVGRTGVVISIDSVVA------HAKTTRMVDVFNFVTNIRQKRPFMVQTQEQY
.||. .... |..|  |. .  .|. .| |.       .....|||.|.||.   . ...|        .   |  .|  ......|.||.  ..|  | 
htvkhysykGWieknaPelareilnilkvvrds.....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql

AFIYGAVLEDL
||    ||. .
afsilmvldlv

subfamily_hpo-7_pd Subfamily hpo-7 454-556 2.1e-07 25.1 In-house 122-225 (263) alignment
Range on Protein: 454-556
Range on HMM: 122-225/263.0
RTVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADhgqftHPLIIHCSAGVGRTGVVISIDSVVA----H--AKTTRMVDVFNFVTNIRQKRPFMVQTQEQY
.||... .. |..|  |. . . |. .| ..       ..|..|||.|.||.     ...|            |  .|  ......|..|.  ..|  | 
htvkhysykgWiekndpelareilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqL

AFIYGAVLE
||    ||.
afsilmvLd

PTPc_DSPc_SM00012 455-556 1.4e-33 110.6 In-house 1-105 (105) alignment
Range on Protein: 455-556
Range on HMM: 1-105/105.0
TVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQF--THPLIIHCSAGVGRTGVVISIDSVVAHAKTT-RMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
||...|.|.|||.|||....|.|.....||  . .   ..|...||||||||||... .| .. . ... . ||.|..|  .|..|| ||||.||| |.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

GAVLE
 |.||
ralle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 455-555 2.9e-14 47.4 In-house 184-280 (290) alignment
Range on Protein: 455-555
Range on HMM: 184-280/290.0
TVTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAV
 .  ..   |||| |.. | .||. .. ..   |    |...|||||.||||  ..|.  .      . .|. . |  .|. |   || . ||  .  ..
klkhlkikswpdksvalstlallrtlrilrkasG....pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil

L
|
l

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 456-569 1.6e-22 74.7 In-house 164-277 (283) alignment
Range on Protein: 456-569
Range on HMM: 164-277/283.0
VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVL
.. . . .| . |      ||.|| | .     .   |...|||.|.|||.| |.. . | .|.|  .||||. |...|..|. .|||..|| ... .||
lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl

EDLLWRNTLIPVVH
|. |  .| |  | 
eqalcgdtqiaavd

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 456-555 1.2e-13 45.5 In-house 217-341 (350) alignment
Range on Protein: 456-555
Range on HMM: 217-341/350.0
VTQFHFTEWPDKGVPKHTSSLLKFIK-------EVK-ADHG--QFTHPLIIHCSAGVGRTGVVISIDSVVA-------------HAK-TTRMVD-VFNFV
| |...  |.| ..  .  |.|. ..       .     |   . . |...||||||||||.....||..              . . .... | ..  |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

TNIRQKRPFMVQTQEQYAFIYGAVL
 ..|..|  |||. .|. ||| |.|
nelrkqrismvqnldqfifiYeall

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 456-551 5e-11 36.7 In-house 192-283 (310) alignment
Range on Protein: 456-551
Range on HMM: 192-283/310.0
VTQFHFTEWPDKGVPKHTSSLLKFIKEVKADHGqfthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIY
|.  .. .|||.|||      .      .  ||    | ..|||||..|..||....  . ...    ||. . .|.....|   .||. || .| 
vslikwpnwpdrgvpdekchtvpqrllaqvrhg....pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 457-559 5.5e-16 53.2 In-house 179-277 (312) alignment
Range on Protein: 457-559
Range on HMM: 179-277/312.0
TQFHFTEWPDKGVPKHTSSLLKFIKEVKADHgqftHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLE
 .. .. |||.|.|    . |...  || |.    .|.| |||||||||| .. |.|..|  .  |  .| .    .|. |   |..  || .   .|||
nhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle

DLL
 | 
fly

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 458-556 1.4e-08 28.5 In-house 222-342 (349) alignment
Range on Protein: 458-556
Range on HMM: 222-342/349.0
QFHFTEWPDKGVPKHTSSLLKFIKeVKAD-----------HGQFTHPLIIHCSAGVGRTGVVISIDSVVA----HAK-------TTRMVDVFNFVTNIRQ
|. . .|.| ..     |.|. .. || |           . . . .|..||||| |||||.. .|....      .        . . |.  .. |. .
qlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelr

-KRPFMVQTQEQYAFIYGAVLE
 .|  |||   |. .|| |.|.
kqrismvqnlaqfiaiyealLk

subfamily_PTPDC1_pd Subfamily PTPDC1 459-549 2.2e-08 28.7 In-house 85-167 (182) alignment
Range on Protein: 459-549
Range on HMM: 85-167/182.0
FHFTEWPDKGVPKHTsSLLKFIKEVKADHGQFthPLIIHCSAGVGRTGVVISIDSVVAHAKTTRmvdvfNFVTNIRQKRPFMVQTQEQYAF
..   |.| ||.  . ..|  .| |.    .    . .|| || |||||.|.   | |.  |.      . .. .|.|||  .||.||  .
vynfgwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvel

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 460-555 8.1e-12 39.2 In-house 187-282 (302) alignment
Range on Protein: 460-555
Range on HMM: 187-282/302.0
HFTEWPDKGVPKHTSSLLKFIKEVKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVL
..| |..| ||.. ..| | ...| | . . .....|    |.|| |....   .| . ..   . . . |..||..|| .|.. .||...| |.|
vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 461-558 1.4e-11 39.0 In-house 174-270 (285) alignment
Range on Protein: 461-558
Range on HMM: 174-270/285.0
FTEWPDKGVPKHTSSLLKFIKEVKADHGQfTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDL
   |||.  |. .  .... | ||    .  .|. .|||||||||  .. ||    .      ..... | ..|  |   ||.. |. |.|  ..| .
vpwwpdqlapedarpmielykwvkkvnpk.ekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_DSP10_pd Subfamily DSP10 467-534 9.3e-06 19.6 In-house 72-133 (159) alignment
Range on Protein: 467-534
Range on HMM: 72-133/159.0
KGVPKHTSSLLKFIKEVKADHGQfthpLIIHCSAGVGRTgVVISIDSVVAHAKtTRMVDVFNFVTNIR
. . ..    |.||.|..    .    ...|| ||. |  . . |  ...| .   . | ..|| . |
qnlkqyfeealefieearkkgsr....vLvhCqaGisrs.atvviaYlmkhln.lslndaykfvkekr

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 480-558 1.6e-17 58.4 In-house 218-295 (297) alignment
Range on Protein: 480-558
Range on HMM: 218-295/297.0
IKEVKADHGQfTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDL
.. ..|.. .   .|..||||||||.|||.  | ..|  .  |. ||  ... .|..|. .||| ||. ..| |||. |
leslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 483-553 9.8e-18 59.1 In-house 184-254 (267) alignment
Range on Protein: 483-553
Range on HMM: 184-254/267.0
VKADHGQFTHPLIIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGA
 | .  .  .||...||.||||.|  . ||| .  |||  ..|.|.|. .||..|. .|.|.|.| .|.  
aknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel

subfamily_eak_pd Subfamily eak 486-564 1.6e-08 28.4 In-house 231-311 (332) alignment
Range on Protein: 486-564
Range on HMM: 231-311/332.0
DHGQFTHPLIIHCSAGVGRTGVVISIDSVVA--HAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDLLWRNTL
 |   ..  || .. |  |.|| . || ..    .| . .  | ...  ...||   | .. |..||| .||. || ||  
ihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnr

subfamily_egg_pd Subfamily egg 489-555 1.6e-07 25.3 In-house 199-267 (307) alignment
Range on Protein: 489-555
Range on HMM: 199-267/307.0
QFTHPLIIHCSAGVGRTGVVISIDSVVAHAK--TTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVL
. ..| ....  || .......|.  . .     .    | . |  .|..|.. |..  .| |.|  ||
nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_CG42327_pd Subfamily CG42327 490-553 3.2e-16 53.9 In-house 246-310 (319) alignment
Range on Protein: 490-553
Range on HMM: 246-310/319.0
FTHPLIIHCSAGVGRTGVVISIDSVVAHAKTT-RMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGA
   ||..||| ||||||.||. |  . . ... | ||. . |  .|. |   |.|.|||.|||  
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 495-558 5.1e-16 52.8 In-house 2-65 (69) alignment
Range on Protein: 495-558
Range on HMM: 2-65/69.0
IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |. ..||.|| |  .|. || ||  . .| ||. |. | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 495-558 1.3e-15 51.5 In-house 1-64 (69) alignment
Range on Protein: 495-558
Range on HMM: 1-64/69.0
IIHCSAGVGRTGVVISIDSVVAHAKTTRMVDVFNFVTNIRQKRPFMVQTQEQYAFIYGAVLEDL
..|||.| ||||  |.|   .|  |. ..||.|| |  .|. || ||  ...| ||. |. | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 553-752 4e-15 50.1 In-house 34-235 (244) alignment
Range on Protein: 553-752
Range on HMM: 34-235/244.0
AVLEDLLWRNTLIPVVHFTDHlQDLHSSGDGRGRSKMTKEF-QTLKS-LCPDPpaSQTRSGRTPDNQPKNRYGNNLPLERNRVILD--SSDHDYINASYM
|||     .|  | .. | .  . . ||    |   .  .. |  .. . |||  |  .    |.|  ||| |  ||.. ||| |   |    |||||..
avlsanatknryinilpfdet.rvilssskkegsdyinanyiqgsqniirpdp..svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfv

K--GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDkscaQYWPNDDSAKFGSYSVSILSTSSDG--DVTTRQLKVTRNSKASHT-VTQYQ
   |  . .| || ||  |  ||| |... .   .|.|    . |    .|||. .  ..    ...  |  |   .. . .|..  . . ||  .| .|
gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfq

FHGWPKHGS
   ||  |.
isnwpsdgt

0050432 (Phosphotyrosine protein) phosphatases II 556-846 3.4e-77 255.1 In-house 10-301 (308) alignment
Range on Protein: 556-846
Range on HMM: 10-301/308.0
EDLLWRNTLIPVVHFTDHLQDLHS-SGDGRGRSKMTKEFQTLKSLCPdppASQTRSGRTPDNQPKNRYGNNLPLERNRVILdSSDHDYINASYMKGV---
| ||.|.| |.|.... ...||.    .  ..... .||..| |..|     ...... |.|..|||| . ||....||.| ....|||||||..|    
elllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssk

-HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPND---DSAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFH
  ..|| || |||.|| ||| ||.. . ..||||..  . . . ||||||..   .| ..| ..| .||. ...|.|.|.|..|  ... |.|||.....
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhyt

GWPKHGSDQQpgARSLMKLIRAVKSSTnkkKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
.|| ||  ..  ...|......|..|    ..  |.|||  | ||||.|...  .. |. ..  ||.|..|| ||  |.. |||.| | | |... |||.
nWpdhgvPps..peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

T
.
l

0051299 (Phosphotyrosine protein) phosphatases II 562-844 5.7e-75 247.7 In-house 2-286 (288) alignment
Range on Protein: 562-844
Range on HMM: 2-286/288.0
NTLIPVVHFTDHLQDLHssgdGRGRSKMTKEFQTLKSLCPDppaSQTRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKG--VHCTF
.| |.| ....... |.     .| ... .||..| ||.||    ...... | |..|||| . ||....||.| .    ...|||||||..|    ..|
dteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkf

ITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR-----NSKASHTVTQYQFHGWPK
| || |||.||.||| ||.. . ..||||..    . . ||||||...| ..| ..| .||. ...|.|.|.|.||.      .. |.|||......|| 
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpd

HGSDQqpGARSLMKLIRAVKSSTNkKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
||  .   ...|....|.|... . ...  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.. |||.| | | ||.. |||
hgvpd..spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 562-848 6.5e-64 211.0 In-house 2-287 (319) alignment
Range on Protein: 562-848
Range on HMM: 2-287/319.0
NTLIPVVHFTDHLQDLHSsgdgRGRSKMTKEFQTLKSLCPDppasQTRSGRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVH--CTF
.| |.| .. ..|. |.|     |  .. |||..||   .|    ...|  ...|..|||| | |. .| ||.|    .. . ||||||.. | .    |
dteievqeLkerlkalas....tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekf

ITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKAS--HTVTQYQFHGWPKHGS
| || || .|..||| ||.. . |..|||..  .     . .|||. .  ..| . | ...     |.  |.||. ..|      .|...|.  || |. 
iatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdv

DQQpgARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
 ..  |.||..|.. .. |..|...  | |||  |.|||| |..    . .. |   .|.|.||. ||. |   ||..| | | ||...|.... .
Pek..atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 563-848 7.3e-73 240.4 In-house 3-294 (298) alignment
Range on Protein: 563-848
Range on HMM: 3-294/298.0
TLIPVVHFTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGVHC--TFI
| | . ... .|| | .     . .....|||.|.|   . .. ... .|.|.|. |||| . ..|.  ||.| .     . ||||||.... .   .||
teieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafi

TTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSDQ
.|| ||..||.||| || . . .|||||..  ..||  . .|||.. ....|. .||.||. . .|...|.|||.... . ...| | .|  || .|  .
atqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpe

QpgARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
.  |.|...|.| |. |... .. ...|.| .| ||.| |.     . .. .  .||.||.||.||..|.. |||||.|.| ||.. |.|.. |
n..atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 564-846 8.3e-61 200.4 In-house 1-285 (290) alignment
Range on Protein: 564-846
Range on HMM: 1-285/290.0
LIPVVHFTDHLQdlhsSGDGRGRSKMTKEFQTLKSlcpDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILD--SSD----HDYINASYMKG--VHCTF
|||| .|.....     |  .|.... ..|..|.|        ..  | |..|...||. | .. . ||..|   |..    ..||||.|.||   .  .
lipvdkfgefva....nghakgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqy

ITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDK-GQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSK--ASHTVTQYQFHGWPKHGS
| || |.. |. |||... . | . |||| .   .  . | ||||. |....| .|. .|. ..  . ..|.|.|. ...  |...|||||.  |...|.
iatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgk

DQQPgaRSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
 ..|   . . .|. .     |. . ||.|||  . ||..|||.|.  | .      .|.|| .| .|  ... |||...| . .... .||..
vtnp..qtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 565-850 1.8e-69 229.2 In-house 2-286 (318) alignment
Range on Protein: 565-850
Range on HMM: 2-286/318.0
IPVVHFTDHLQDLHSsgdgRGRSKMTKEFQTLKSlCPDPpASQTRSgRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGVH--CTFITT
|.| .. .|.. |..     |. ....|.. |.  ...  .....|  .| |. |||| | |. .. || |.      . |||||.|. | .   ..| .
isvedleshvrrlre....sGelllseeyerlsr.seet.vtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaa

QMPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN-SKASHTVTQYQFHGWPKHGSDQQP
| ||| |..||| ||.. . ..|||| . . .. . ...|||...| ..|.  | . .. . .| . |..||||. ...| .| ||..  || .|. ...
qaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg

gaRSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYE
   ||..|.| |..  .|...  |.||| .| ||||||..    . .|..   ||.||||| ||  |   ||||. | | |.|. |.|.. . |
..aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte

subfamily_PTPRB_pd Subfamily PTPRB 565-848 1.1e-63 210.0 In-house 7-289 (293) alignment
Range on Protein: 565-848
Range on HMM: 7-289/293.0
IPVVHFTDHLQDLHSSGDgrgrSKMTKEFQTLKSLCPDPPasqTRSGRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVHC--TFITT
| . .|..|......  |     ....|...||..  |     . . ... |. |||| | || . .|| |    |.|. |||||.|..| ..   ||.|
iklekfeehvkkmkadsd....lrfseeyeelkavgkdqa...vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPND-DSAKFGSYSVSILSTSSDGDVTTRQLKVTRnSKASHTVTQYQFHGWPKHGSDQQp
| |||.|| ||| ||.. | |.|||| .     |  | .|||.| ..  .|. .|.......  | ..|.||... .|....|.||.|  || ||  .. 
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPek.

gARSLMKLIRAVKSST-NKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
 ...|....|.|.... .....  |.||| .| ||||.| .  . . .| | | |||| .|  || .|...||||..| | .... ..|....
.tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke

subfamily_PTPRG_pd Subfamily PTPRG 565-850 1.5e-60 200.0 In-house 1-293 (563) alignment
Range on Protein: 565-850
Range on HMM: 1-293/563.0
IPVVHFTDHLQDLHSSGDGRgrskMTKEFQTLKSLCPDPpASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS-----SDHDYINASYMKGVH--CTFIT
.|| .|. |. .||..|| .    ...||. |.| . .    .. . . |.|. |||| | .. .| || | .     ...|||||.|..| .    ||.
vpvkefakhvaslhadgdig....fseefealqsetisk.dldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafia

TQMPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR-----NSK--ASHTVTQYQFHGWPK
|| ||..|. ||| |... . ..|||. . . .  . | .|||.|.| ..|. .| . ..      |.|.|..       ...    ..|.||..  || 
tqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

HGSDQQpgarSLMKLIRAVKSSTNKKKE-FSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
||. ..    ||..|| ..|||. .|.|   |.||| .| ||||...     . || . ..|..|...| .|| |   |||||.| | .... | . ...
hgvPeh....slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

YE
 |
te

0043336 (Phosphotyrosine protein) phosphatases II 567-844 1.1e-65 217.2 In-house 4-277 (278) alignment
Range on Protein: 567-844
Range on HMM: 4-277/278.0
VVHFTDHLQDLHSSGDGRgrskMTKEFQTLKSLCPdppaSQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGV--HCTFITTQM
| .. ..|..|. ..  .    . .||..| |  .      .. .. |.|..|||| . ||....||.|.. .    .|||||||..|     .|| || 
vkdllkallelllnlktl....lllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqg

PLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPnDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQqpGA
||| || ||| ||.. . .|||||..    . . |||||| ..| ..| ..|  |.. ...|.|.|.|.||.  .. |.|||.|...||| ||       
PlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe..sl

RSLMKLIRAVKSSTNkKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
 .|.....||..  . ...  .||||  | ||||.|...  .. |.  .  ||....|| ||  |.. |||.. | | ||...|||
sllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 567-651 9.7e-07 22.9 In-house 7-84 (95) alignment
Range on Protein: 567-651
Range on HMM: 7-84/95.0
VVHFTDHLQDLHSSGDgrgrSKMTKEFQTLkslCPDPPASQTrSGRTPDNQPKNRYGNNLPLERNRVILDS-SDHDYINASYMKGV
|  |  |. ..||  |     .. .||...        |. |  | .  | ||||. | .| .  ||.| .  | ||||| .. | 
vsvfhshvlemhsnsd....qefdnefksi...smtsgapyt.vgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy

0040438 (Phosphotyrosine protein) phosphatases II 568-845 6e-69 228.1 In-house 3-277 (317) alignment
Range on Protein: 568-845
Range on HMM: 3-277/317.0
VHFTDHLQDLHSSGDgrgrSKMTKEFQTLKSLCPDppasQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGV--HCTFITTQMP
... ..|.||. |.      .. .||..| || .|     .. .. |.|..|||| . ||....||.| . .    .|||||||..|     .|| || |
ldlllalldllksdf....talleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgP

LPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQqpGAR
|| || ||| ||.. . ..||||..  .  .. ||||||.... ..| ..| .||.  ....| |.|.|.  ... |.|||.....||| ||  .    .
lpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvpp..spd

SLMKLIRAVKSSTNkKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
.| ....||... . ...  .||||  | ||||.|..|  .. |. ..  ||....|| ||. |.. |||.| | | |....||| 
llldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk

subfamily_PTPN6_pd Subfamily PTPN6 570-848 8.5e-58 190.7 In-house 9-301 (306) alignment
Range on Protein: 570-848
Range on HMM: 9-301/306.0
FTDHLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPPAsQTRSGRTPDNQPKNRYGNNLPLERNRVIL---DSSDHDYINASYMK----GVHCTFITTQMPL
  .. ..|. ...  ... ...||..|.         . . |. |.|. |||| | || . .||||   . ...|||||.|.|    | ....|.||  |
ieqrvselekeeeslekagfeeefeelqqeeakkll.srkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl

PTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPNDDS-AKFGSYSVSILSTSSDGDVTTRQLKVT--RNSKASHTVTQYQFHGWPKHGSDQQPGA
.|||||||.||.. .   |||.  .     . ||.|||.  .  ..|..||. .| .|  | . |.|.|.  ...| ...| ||.|. || ||  ..|||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpga

R-SLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQI---AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
  .... ... ......... .|.||| .| |||| |      . .|        .|| ..||..|. | ..||||. | | |..|..|..|..
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 573-848 2.1e-58 192.6 In-house 6-282 (287) alignment
Range on Protein: 573-848
Range on HMM: 6-282/287.0
HLQDLHSSGDGRGRSKMTKEFQTLKSLCPDPpASQTrSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFW
.. ..  .|  .|.   .. |..|...  ..  . |  . ...|..|||. . |. . .||.|   ..|||||....| .    || .. |.  |. .||
kfgefvakghakgnegfknqftvleqvtqre.devt.hniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfW

SMVFDFKPSTIVMLND-KGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKA--SHTVTQYQFHGWPKHGSDQQPgARSLMKLIRA
 .. | ....|||| . | . .. | ||||...|  .| |....|.     ... |.|.|....||   ..|.|||.  |...|  ..| . .|. . . 
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtep.qtillvieem

VKSStNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
.|.   |. . ||.|||  . ||...|| |   | .  .   .|.|| .|  |  ... ||| |.| | .... |||.. .
yktq.rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe

subfamily_PTPN9_pd Subfamily PTPN9 575-844 3.3e-52 172.4 In-house 4-290 (297) alignment
Range on Protein: 575-844
Range on HMM: 4-290/297.0
QDLHSSGDGRGRSKMTKEFQTLKSlcpDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGV--HCTFITTQMPLPTTVSD
..| .    .|.. ..||.. ...    |.. .    ... |  |||| . | ... || | . |     |||||... |   . .||.|| ||. ||||
eelvayvkekgkrGlskeyaeirn...epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWP--NDDSAKFGSYSVSILSTSSDGDVTTRQLKVT-RNSKASHTVTQYQFHGWPKHGSDQQpgARSLMKL
|| ||.. .  .|||     .     |.||||  ...||.||..||| ... .  | ..|.|...  . . | .|| .|| .|| .|  ..  | ||...
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPss..aaslldv

IRAVK---SS---------TNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
...|.   ..         . . ..  |.||| .| |||| |.|   |.... | . ||...||| ||. |   .||.| |.| |  . || 
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 582-842 6.3e-67 220.6 In-house 16-277 (288) alignment
Range on Protein: 582-842
Range on HMM: 16-277/288.0
DGRGRSKMTKEFQTLKSLcpdPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFD
. |.|. ...|...| .|      ...  || . |..|||| | ||.. .|| |.     .. |||||||..| .   ..|.|| ||. || ||| .|..
sarnrtgfseeynsLaal...ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

FKPSTIVMLNDK-GQSDKSCAQYWPNDDS-AKFGSYSVSILSTSSDGDVTTRQLKVTrNSKASHTVTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSsTN
 | ||||||..   . .. | .|||..|   ..||  | ....   .|...|.| .   .|   ..||||. .|| ||  .   .. |..|.| ||  .|
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPe..skapllellrqvkv.an

KKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
...   |.|||  | ||||.| ..   | .. | | .|.. ||. ||  |...|||.. | | |||. .
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

0047943 (Phosphotyrosine protein) phosphatases II 584-844 1.1e-70 233.6 In-house 9-272 (273) alignment
Range on Protein: 584-844
Range on HMM: 9-272/273.0
RGRSKMTKEFQTLKSLCPdppASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTI
 |.... .||..|.||.|      .. .. |.|. |||| . ||....||.|.....|||||||..|  .  .|| ||.||| || ||| ||.. . ..|
lgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMLNDKGQSDK-SCAQYWPNDD---SAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSSTNKK-
|||..  . ..  ||||||..    | ..| ..| .||. ...|.|.|.|..|. ... |.|||.....||| ||  .     ||...|..|..  ..  
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp..slesllefielvrkalealp

KEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
..  ..|||  | ||||.|...  .. |. ..  ||....|| ||  |.  |||.| | | ||.. |||
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0039614 (Phosphotyrosine protein) phosphatases II 584-844 4.4e-70 231.8 In-house 29-289 (297) alignment
Range on Protein: 584-844
Range on HMM: 29-289/297.0
RGRSKMTKEFQTLKSLCPDppasqTRSGRTPDNQPKNRYGNNLPLERNRVILDS-----SDHDYINASYMKGVHC---TFITTQMPLPTTVSDFWSMVFD
 ..... .||..|.|| ||     .. .. | |..|||| . ||....||.| .      |.|||||||..| ..   .|| || ||| || ||| ||..
nsktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

FKPSTIVMLNDKGQSDKSCAQYWPNDDSaKFGSYSVSILSTSSDGDVTTRQLKVTRnSKASHTVTQYQFHGWPKHGSdqQPGARSLMKLIRAVKSSTNKK
 . ..||||..    .. ||||||.. . ..| ..|  |..  ....|.|.|.||. .. |.|||..|..||| ||    | ...|......|..  .. 
qgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgv..ppslellleflelvrealael

-KEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
 |.  .||||  | ||||.|..|  .. |. ..  ||....|| ||  |.. |||.. | | |....|.|
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_PTPN23_pd Subfamily PTPN23 584-846 5.2e-57 187.9 In-house 12-282 (288) alignment
Range on Protein: 584-846
Range on HMM: 12-282/288.0
RGRSKMTKEFQTLKSLCPDPpASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVHC---TFITTQMPLPTTVSDFWSMVFDFKPST
 |.... |.|. |..      | ..       .  |||. . || ..||| |..|  ||||||..|..     .||.|| ||..|..|||.||.. | |.
dgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLNDKGQSDKS-CAQYWPND--DSAKFGSYSVSILSTSSDGDVTTRQLKVTRN-SKASHTVTQYQFHGWPKHGSDQQPGarSLMKLIRAVKS---STN
|||| .| . .|  ...|||.|  .. ||| .||.. |. . . .  |.||.. . ..| ..|.  |.. ||..|  . |.  .|.... .|.|   ...
iVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPe..tllqfldevesayeavq

KKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
.| .  ..|||..|.||||||.  .  .... .|. . || | |. ||..|   ||..|.. |.||.. |. . 
rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 584-852 6.3e-28 92.7 In-house 13-288 (307) alignment
Range on Protein: 584-852
Range on HMM: 13-288/307.0
RGRSKMTKEFQTLKSLCPDPPASQTRSGrtpdNQPKNRYGNNLPLERNRVILD--SSDHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPS
.| .... ||. |    |.  . .. |     |. |||| .    ...|...       ||| | |.        || .| || .|. .||.|. . |  
kgvqalvdefrvlakktpegvtveafsa....ntdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekve

TIVMLNDKGQSDK-SCAQYWPNDDSAK--FGSYS----VSILS---TSSDGD-VTTRQLKVTRnSKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAV
...|| .  .  |  | |||| ..  |  ||. .    |. |     . | | .   .|||   .. | |....|.. || .|  |     . . |. ||
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqi..nltainlleav

KSSTNkkkefSILVHCLSGSGRTGVFCTAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREY---LHTENYEQL
.  ||      ..||| .| ||.|   .      .. .|    |. . |. ||..|   .||| .| . . |. ||   |. | ||.|
rydtn.....pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel

0036941 (Phosphotyrosine protein) phosphatases II 585-848 4.5e-71 234.9 In-house 11-281 (297) alignment
Range on Protein: 585-848
Range on HMM: 11-281/297.0
GRSKMTKEFQTLkslCPDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIV
..... |||..|   .|  .   .. .. |.|..|||| . ||....||.||....|||||||..| .   .|| || |||.|| ||| ||.. . ..||
flalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIv

MLNDKGQSDK-SCAQYWPND--DSAKFGSYSVSILSTSS--DGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSSTNKK-
||..  . ..  ||||||..  .| ..| ..|  ||...  ..|.|.|.|.||  ... |.|||.....||| ||  .   ..||...|..|..  ..  
mltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe..spaslldfielvrkvlkllp

KEFSILVHCLSGSGRTGVFCTAMECIAQIA---EGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
..  .||||  | ||.|.|..|  .. |.    .   |||...|| ||  |.. |||.| | | ||.. |.| . .
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0045450 (Phosphotyrosine protein) phosphatases II 585-844 9.8e-65 214.6 In-house 25-304 (307) alignment
Range on Protein: 585-844
Range on HMM: 25-304/307.0
GRSKMTKEFQTLKSLCPDPpASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS-----SDHDYINASYMKG----------VHCTFITTQMPLPTTVSDF
..... |||..|.|.....    ..... | |..|||| . ||....||.| |     .|.|||||||..           .  .|| || ||| || ||
fltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WSMVFDFKPSTIVMLNDKGQSDKS-CAQYWPNDDSA-KFGSYSVSILSTSSDGDVTTRQLKVTR--NSKASHTVTQYQFHGWPKHGSDQqpGARSLMKLI
| |... . ..||||..    ..  ||||||....   .| . |  ||.. ....| |.|.||.   .. |.|||.....||| ||  .     .| ..|
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp..sfeelldfi

RAVKSSTNKK-KEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
..|..  ..  |.  .||||  | ||||.|..|  .. |. ..     ||....|| ||. |.. ||..| | | ||...|.|
eevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_PTPN12_pd Subfamily PTPN12 585-846 2.4e-55 182.5 In-house 6-279 (290) alignment
Range on Protein: 585-846
Range on HMM: 6-279/290.0
GRSKMTKEFQTLKSLCPDPPASQ---TRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFD
|. ...||||.||.|     |..   | .|... |. |||| . || . .|| |       . |||||...|||.  ...| .| |||.|..||| |...
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwe

FKPSTIVMLNDKGQSDK-SCAQYWPND--DSAKFGSYSVSILSTSS-DGDVTTRQLKVTRNsKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSS
.. . .||.  .   .|  |..|||.   .. .||...|.  .    | | . |.|||... |.|..|.|.... || ||  ..  | ||..||..|.. 
knveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPss..aksllelielvrel

TNkKKEFSILVHCLSGSGRTGVFCTA---MECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
 . ...  ..||| .| ||||. ..     | . .    ...|.|. |  || .|   |||.| | . |. . |....
qe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

subfamily_PTPRN_pd Subfamily PTPRN 585-842 8.8e-41 134.5 In-house 27-290 (297) alignment
Range on Protein: 585-842
Range on HMM: 27-290/297.0
GRSKMTKEFQTLKSLCPDPPASQtrSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGV---HCTFITTQMPLPTTVSDFWSMVFDFK
 .... ||...|..   .| ...   .....|  |||. . || . .|| |..    ...|||||| .      . ..|.|| ||..||.||| ||..  
nkdrlekewealcayeaepstke..vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

PSTIVMLNDKGQ-SDKSCAQYWPNDDSAKFGSYSVSILST---SSDGDVTTRQLKVTRNSKaSHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTN
   ||.|    . . | |..|||.. |. .. | | ..|    . |  | .  ||  ..|. . ||||. |  ||..|   .  |.||... | |  |  
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse.trtvtqfhflswpeegvPas..aksllefrrkvnksyr

KkKEFSILVHCLSGSGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
  .  .|.||| .|.|||||..     ..... |   .||  |.. || .| ..|.|.... |.. .. |
G.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 585-849 1.5e-24 81.2 In-house 22-293 (305) alignment
Range on Protein: 585-849
Range on HMM: 22-293/305.0
GRSKMTKEFQTL-KSLCPDPPASQTRSGRTPD-NQPKNRYGNNLPLERNRVILDS-SDHDYINASYMKGV---HCTFITTQMPLPTTVSDFWSMVFDFKP
|  |. .||. | |   ||       . ...| .. |||| .    ... | ||  |  ||| | |.      .  || .| ||  |. .|| || . | 
gvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkv

STIVMLNDKGQSDK-SCAQYWPNDDSAKFGSYSVS---ILSTS----SDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKHGSdqQPGARSLMKLIRAVKS
  ||||    .  |  ||||||     |    |      .| |     | ..    |..| . . . .| . |.  ||  |    |   . ..|. |.. 
eqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgv..ppckltslellsairg

StnkkkEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSV-DIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHtENY
|     .  |.||| .| ||||   .    . .|||  ..  . . || || .|   .|.. .| | . |. .|.  |.|
s.....kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl.eky

subfamily_CG7180_pd Subfamily CG7180 586-845 7.8e-50 164.2 In-house 12-291 (296) alignment
Range on Protein: 586-845
Range on HMM: 12-291/296.0
RSKMTKEFQTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPS
| |.  |.. .  | |     . . |   .|. |||. . .| . |||.|..    .. |||||.|. .   .  .| |..|   || .||..|.| . |
rrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

TIVMLNDKGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN-----------SKASHTVTQYQFHGWPKHgsDQQPGA-RSLMKLIRA
..|.| ....  | . .||||.  ...|   | |... .  ....|..|.|..           .    .|...|.  |. .  |. |    .|..|.| 
avvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWele..dkvPlstnalielrrr

VKSSTNKK----KEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
|..  .|     .|  ..|..  |..|.||....  .. .. . . ||.|. || || .| | |.. ||| . |.|. |.. 
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 587-844 3.7e-37 122.8 In-house 6-259 (267) alignment
Range on Protein: 587-844
Range on HMM: 6-259/267.0
SKMTKEFQTLKSLCPDppASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVML
 .. |||. .| . ..   |.     . .|| .||. .||| . .||||  ....||||||..| .   .|| || ||  |..||. .. | | ..||.|
ceiekefelikkisdt..sstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

NDKGQSDksCAQYWPND--DSAKFGSYSVSI--LSTSSDGDVTTRQLKVtrNSKASHTVTQYQFHGWPKHgSDQQPGARSLMKLIrAVKSSTNkkKEFSI
   .. .    ..||    .. |.   .|         | .. | .||.  . ...| || | .. |    ....|  . |. .. | .   |   .  .
tkvftdn..irlfwPPkmgqakkyqdltvehslekeendyqiitlelkf..knesahnvtlyyykkwnin.tnnkpylkplfgil.aknqlen..gnrPl

LVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
.|.|  | ||.| | ..   . .. . . .|||. .. .|  |. .|.| |.| . .|.. || 
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 587-844 6.1e-36 118.8 In-house 20-279 (439) alignment
Range on Protein: 587-844
Range on HMM: 20-279/439.0
SKMTKEFQTLKSLCPDPPASQTRSGRTPdNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPST
  ....|....|  ||  .  .   .   .|.|||| .  ...  ||.|          |||| |.|| .    .|.||.|   |. ||| .|.. | .|
eifkeifekinstspdyaciaslaaqey.dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvt

IVMLNDKGQSDKscaqYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN---SKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNKKKE
|||| .  .| |    ||| |. . .|  .| .       . . | .||  .   ..  .|| |...  ||..    |  |  .....||..|. .|.. 
ivmltnlvesyk....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaq..ashvldflrainsandkeey

FSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
  ..||| .| ||||   .   .. |.   . |||   ||.|| .| |.||.  .| | |. . | .
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 588-845 1.2e-53 177.5 In-house 35-293 (319) alignment
Range on Protein: 588-845
Range on HMM: 35-293/319.0
KMTKEFQTLKSLCPdPPASQTRSgRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTI
|.  ||. .  | . . | || .   ..|. |||..| |. ..|.| |.  .     ||||||...|      .|..| ||. |. ||| |..... |||
klevefrracklgv.nladqtfa.nldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLNdkgqsDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN--SKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKK-EF
|.|       . |.||||..   | . . |.. |     . . |.......   |    .||. | |||..|  ..|    ||.|.. |.  |.|.. . 
vllt.....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp..sdlmrlvkkvrhltskenhra

SILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE-YLH
.|.||| .|.|||||. .    . .. | . ||....|. || .| ..||   .| | |  . | .| 
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 588-846 3.1e-52 172.4 In-house 16-278 (281) alignment
Range on Protein: 588-846
Range on HMM: 16-278/281.0
KMTKEFQTLKSLCPDPPASQTrsgRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTI
 ...|...|...  | .|. .   ....|. |||| |    .  || .    .... |||||....|..    .|.|| |.|... .|| ||.. | |.|
Gfieeyeklaaigvdntatas...kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

VMLNDKGQSDK-SCAQYWPNDD-SAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKKEFS
||.  . ...|  | .|||.|. . |.| . |. .....     .|..|..|.|  . .|.| ..  || ||  ...  . |..  ..|.. |.||.. .
vmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPatt..kellefrkevlkltekktkap

ILVHCLSGSGRTGVFCTAMECIAQIA-EGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
...|| .| ||||.. .    . ... |  ..|. ..|. || .|. .|||   |.| | .. ..|. 
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 588-847 6.7e-40 131.7 In-house 11-280 (287) alignment
Range on Protein: 588-847
Range on HMM: 11-280/287.0
KMTKEFQTLKSLCpDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSS---DHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIV
.. ||...||    .  .   ..     .  ||||.. ||.. .||.|        ||||| |. . .   .||..| |...|| ||| .|.. . ....
dvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

ML-NDKGQSDKSCAQYWPNDD-SAKFGSYSVSILST-SSDGDVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSdqQPGARSLMKLIRAVKSSTNKKKE-
..  .  .. . | .|||. .   . | ||| .|.    . . ..| |..     . .. | |...  ||...    | | .|....  ||   . ... 
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvl..aPtavglirfvldvkqhielarda

---FSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTE
     ..||.  | ||.|.. . . .. .  .   ||. ..|  ||  |  .||.   . ..|| .  | .|.
sevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 588-849 3.8e-36 119.2 In-house 28-288 (290) alignment
Range on Protein: 588-849
Range on HMM: 28-288/290.0
KMTKEFqtLKSLCPDPPASQTRSGrTPDNQ---PKNRYGNNLPLERNRVIL-DSSDHDYINASYMKGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVM
...||.  |. | |  |. .       |..    |||| .    .. |||| |  | ||. | |.||.. .|| || .|  || |.| || . | ..|||
elakey..leklkpylpvqylerk.ifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivm

LNDKGQSDK-SCAQYWPNDDS--AKFGSYSVS-ILSTSSDGDVTTRQLKVT-RNSKASHTVTQYQFHGWPKHGSdqqpgARSLMKLIRAVKSStnKKKEF
| .  .  |  |.||.|. .     ||...|   .... | ..  . | |  ..|  .| .  ..   || .       | | . |.| ...   .|   
lceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv.....alstlallrtlril..rkasG

SILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENY
 . ||| .| |||| | .   ..  . .| ..|. ..|. ||  |.. || . .|    |.. ..    .|
pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky

subfamily_ptpA1_pd Subfamily ptpA1 588-800 5.5e-33 109.3 In-house 22-252 (418) alignment
Range on Protein: 588-800
Range on HMM: 22-252/418.0
KMTKEFQTLKSLC-PdppaSQTRSGRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVHC-TFITTQMPLPTTVSDFWSMVFDFKPSTI
|. .||. |.    |    |.|  |    |  |||| | ||... || |    |    ||||| |. | .   || || ||| |..||| ||.. .   |
kikeefrlleesvgp....setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcrii

VMLNDKGQS-DKSCAQYWPNDD-----------SAKFGSYSVSILSTSSDG--DVTTRQLKVTRNSKAsHTVTQYQFHGWPKHGS-DQQPGARSLMKLIR
|||. . .     | .|||..               ||.||| ..    |   .. ||....| . .. . .||||. ||| |   |.    | |.. | 
vmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeget.rditqyqyegwpdhnipdhtqpfrqllhsit

AVK--SSTNKKKEFSILVHCLSGSGRTGVFCTAMEC
  .     .  ..  |.||| .| |||| ||||.  
nrqnqiipssdrnvpiivhcsagvgrtgtfctavim

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 589-850 2e-89 294.6 In-house 23-290 (297) alignment
Range on Protein: 589-850
Range on HMM: 23-290/297.0
MTKEFQTLKSLCPdpPASQTRSGRTPDNQ---PKNRYGNNLPLERNRVILDSS----DHDYINASYMKGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTI
.  .. . . ||.  |....... . ...   .|.|| | || ...||.| .     | ||.|||..||..  .|||||| ..|| ||| ||.| ..|||
rhtdvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvsti

VMLNDKGQSDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSDQQPGARSLMKLIRAVKSSTNKKKEFSI
|||||. ..||.||.||... ...||. || .||.|.      |.|.||... || . | ||||  ||..  ...  |.||.|||  |. . ....|  .
vmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPl

LVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYE
|||||.| |||||..|  ...|.. . ..||||..|| || .|...|||.|.|.| |... |.| .|...
lvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtr

DSPc_SM00195 589-844 2.7e-73 241.9 In-house 2-262 (263) alignment
Range on Protein: 589-844
Range on HMM: 2-262/263.0
MTKEFQTLKSLCPDPpasQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIV
. .||..|..  ..    .|.... . |. |||| | || ...||.|....    .|||||.|.||     ..| ||.|||.||.||| ||.. | ..||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKGQ-SDKSCAQYWPND--DSAKFGSYSVSILSTSSDG-DVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKkE
||..  .   . |..|||..  .. .||..|| . .. ..  ....|.|..| .  . ...|||||...||.|| ....  .|...|.||||.|.... .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdst..ksvlellravkksksts.s

FSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.| ||.| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 589-844 2.7e-73 241.9 In-house 2-262 (263) alignment
Range on Protein: 589-844
Range on HMM: 2-262/263.0
MTKEFQTLKSLCPDPpasQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIV
. .||..|..  ..    .|.... . |. |||| | || ...||.|....    .|||||.|.||     ..| ||.|||.||.||| ||.. | ..||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNDKGQ-SDKSCAQYWPND--DSAKFGSYSVSILSTSSDG-DVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKkE
||..  .   . |..|||..  .. .||..|| . .. ..  ....|.|..| .  . ...|||||...||.|| ....  .|...|.||||.|.... .
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdst..ksvlellravkksksts.s

FSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
  |.|||  | ||||.|.|.  .. ...|.. ||||..|| ||  |.. |||.|.|.| ||.| ||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0046845 (Phosphotyrosine protein) phosphatases II 589-846 2.8e-73 242.1 In-house 2-276 (284) alignment
Range on Protein: 589-846
Range on HMM: 2-276/284.0
MTKEFQTLKSLCPDPPaSQTRSGRTPDNQPKNRYGNNLPLERNRVILDS-----SDHDYINASYMKGV-------HCTFITTQMPLPTTVSDFWSMVFDF
. .||..| || ...   ... .. | |. |||| . ||....||.|.|     .|.|||||||..|        ...|| ||.|||.|| ||| ||.. 
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KPSTIVMLNDKGQSDK-SCAQYWPNDD-SAKFGSYSVSILSTSSDGDVTTRQLKVTRN--SKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSST
. ..||||..  . ..  ||||||... . ..| ..| .||.  ..|.|.| |..|..  .. |.|||......|| ||  ..  ...|....|.|... 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvpps..pedlleflrlvrell

NK-KKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGD---SVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
.. ...  |.|||  | ||||.|.... .. |. ...    ||....|| ||  |...|||.| | | ||.. ||| .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

subfamily_Ptp69D_pd Subfamily Ptp69D 589-848 6.3e-57 188.0 In-house 24-290 (307) alignment
Range on Protein: 589-848
Range on HMM: 24-290/307.0
MTKEFQTLKSLcpdPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIV
..||...|..        .|. .   .|. |||| .  . ...||.|       | ||||||..||   . .||. | |. .|. ||| |. . .  .||
lakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLNDKGQSDK-SCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNS------KASHTVTQYQFHGWPkhGSDQQPGARSLMKLIRAVKSSTNKK
|| . .. ..  ||.|||..|  ..|.  | . |... .| . |.|.|...       ..|. |.||.. ||.   |     ||.|.|||. |..  ...
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk..DskvPevargllklieqvrelykln

kEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
 .  |.|||  |.||.|.| .    . |. . |.||||.||| || .|  .||  | | | |  . .| .  .
.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygd

subfamily_PTPN13_pd Subfamily PTPN13 590-845 6.5e-48 158.3 In-house 14-270 (273) alignment
Range on Protein: 590-845
Range on HMM: 14-270/273.0
TKEFQTLKSLCpdpPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHdYINASYMKGV----HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLN
..||..|. |    |  ....|.. .|. |||| | || .. ||.|...   |||||..|      . ..| .| |||.||.||| ||.. | . |.|. 
aeefkelrelk...pldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

DKGQS-DKSCAQYWPNDDSAKFGSYS---VSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNkkKEFSI
 . ..    | .|||.  . |   ..   |. | .    . . |.|.|.  .|..|. |.. .|  || ||  ...   .|..... |..  .  ..  |
lekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssa..aellqfvaevrrlqt..dagPi

LVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
.||| .| ||.|.. |    .  |.   ..|. ..|. ||  |   |||.. | | |..| | |.
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 590-848 4e-43 142.2 In-house 18-297 (301) alignment
Range on Protein: 590-848
Range on HMM: 18-297/301.0
TKEFQTLKSLCPDppasQTRSGRTPDNQPKNRYGNNLPLERNRVILDSS------DHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTI
 .....||.  ..    ..  | . .|.. ||. |. ... ||.||          ..||||||..|.     || .| |.  |. ||| .... ||..|
eeqykelkegedk....sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLNDKGQS-DKSCAQYWPN--DDSAKFGSYSVSILSTSSDGDVTTRQLKVT----------------RNSKASHTVTQYQFHGWPKHGSDQQPgaRSLM
||. .. ..  ..| |||||   .| .||  .| . ..    | . |||.|.                ...|.|..|.|.|   ||..|  ..|  |  .
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep..rtvL

KLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
. |  |   ..|     ..|||  . .|.||.|.    . |      ||.|| .| .|  ..  |.| | | . |.|| .||. ..
qviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 594-843 6.2e-21 69.3 In-house 15-268 (281) alignment
Range on Protein: 594-843
Range on HMM: 15-268/281.0
QTLKSLCPDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDS-----SDHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLND
| .  |  |||.        | |. |||| |   |.  || |          ||| | |..    .  .| || |   | .||| |... . ..|||| .
qefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

KGQSD-KSCAQYWPNDDS--AKFGSYSVSILSTSSDGDVTTRQLKVTRNSKaSHTVTQYQFHGWPKHgsdQQPGAR-SLMKLIRAVKSSTNkkkefSILV
  ... . ||.|.| .     .|  .|||   .. .  . | .|... . . .. .|.. .. ||     | |..   ..|..| ... .        ..
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyege.trlithwlwkewpdw...qvpessevmlkilrkirarst.....ppvi

HCLSGSGRTGVFCTAMECIAQIAE-GDSVDIFQTVKILRA-DRMQFVQTEEEYAFTYEVIREY
|| .| ||.| . .   ..  |       || | |  ||   |   ||| ..| . ..|. ..
hcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 599-848 5.2e-62 204.8 In-house 31-292 (325) alignment
Range on Protein: 599-848
Range on HMM: 31-292/325.0
L-CPDPPASQTrSGRTPDNQPKNRYGNNLPLERNRVILD----SSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD
|  .| . ...     |.|. |||. | ..|...||.|     ... |||||||..      .|...|.||..|. |.| .|.|.. | .|.||   . .
llpsddgiakk.vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgk

KSCAQYWPND--DSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKA-SHTVTQYQFHGWPKHGSDQQPGA-RSLMKLIRAVKSS--TNKKKEFSILVHCL
..||.|||..  .| .||.  |.. .     |   |.|.| . .|  . .| |.|. .|.  | ...| .  |...|. ||.    .| |    ||||| 
drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

SGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
.| |||||| .    .|.. |  .||||. || ||.|| . |.| ..| . || . |.. . |
aGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 601-849 6.4e-124 407.9 In-house 29-282 (315) alignment
Range on Protein: 601-849
Range on HMM: 29-282/315.0
PDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-S
|||.....|..|...|..||||.|.|||...||.|    || |.|||||||.|.|..  ..|..|.||...|.|||.||.. |..||||...| ..|| .
pdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkik

CAQYWPN--DDSAKFGSYSVSILSTSSDGDVTTRQLkVTRNSKASHTVTQYQFHGWPKHGSDQQPGarSLMKLIRAVKSStNKKKEFSILVHCLSGSGRT
|.||||.   ||..|||..|..||...|.| ..|.| |||.|..|.||||.||..||..|.|.| .  ||.|||..||.. |.|||||.||||..| |||
crqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts..sllklikevkad.ngkkefsllvhcsaGvGrt

GVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENY
||.....|..|||....|||.|..||.|||.|...||||||||| |....|.|.  | 
Gvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt

0045098 (Phosphotyrosine protein) phosphatases II 601-845 9.9e-63 207.4 In-house 18-273 (278) alignment
Range on Protein: 601-845
Range on HMM: 18-273/278.0
PDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVIldssdhDYINASYMKGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKG-QSDKSCAQYWP
. .. |.   .  ..|..|||| . ||....||.      |||||||..| . .|| || |||.||.||| |... . ..||||..    . . ||||||
llgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

NDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR-----NSKASHTVTQYQFHGWPKHGSDQQPGARSLMKLIRAVKSSTN------------KKKEFSILV
...|  .| ..| .||..  .|.|.| |.||      ..  |..||......|| ||.  .|  .|. .|.. ...  .              ..  .||
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCLSGSGRTGVFCTAMECIAQIaeGDSVDIFQTVKILRADRMQ-FVQTEEEYAFTYEVIREYLH
||  | ||||... |. .. ..  .. ||....|| ||  |..  ||..| | | ||...|.|.
HCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 601-708 2.1e-38 126.8 In-house 30-152 (392) alignment
Range on Protein: 601-708
Range on HMM: 30-152/392.0
PDPPASQTRSGRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLND-----KGQ
|.|............|..||||.|.||....||.|    |..|.||.||||......  ..|..|.| .....|||.|||.....||.|...     ||.
pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgd

SDKSCAQY----WPNDDSAKFGS
.....||.    ||..|  |. |
dartvaqfhftewPdkdvpkhts

subfamily_PTPRD_pd Subfamily PTPRD 603-850 6.8e-74 244.5 In-house 35-287 (564) alignment
Range on Protein: 603-850
Range on HMM: 35-287/564.0
PPASQTRSGRTPDNQPKNRYGNNLPLERNRVILD----SSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCA
.. ..... . | |..|||| | .. ...||.|      .. ||||||...| .   ..| || ||..|..||| ||.. . ||||||.    ..|  |.
gqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkch

QYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKV-TRNSKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTnKKKEFSILVHCLSGSGRTGVF
.|||.......|.. |.. ..    |.. |..|. . .|. |..|.|..|  || ||  ...  .||..||| |.... ....  |.||| .| ||||.|
kYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa..tslLdlirkvraln.epdagPivVhCSaGVGRTGtf

CTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYE
..   .. .| | . |||.|.|| ||..|   ||||| |.| .|.| |.|.  | |
ividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte

subfamily_PTPN3_pd Subfamily PTPN3 603-841 4.6e-49 161.8 In-house 28-272 (280) alignment
Range on Protein: 603-841
Range on HMM: 28-272/280.0
PPASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMK------GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCA
 |  ..   | |.| .|||| . || .  ||.|..|. |||||.|..      |.   .|.|| ||..|..||| ||.. | |.|||| .  .. .  | 
kpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYWPN-DDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNS-KASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNkKKEFSILVHCLSGSGRTGV
||||. .|. ..|..|| . .....  . .|.| ..... | .....| |.  || ||  ...   ....... |..  .  ||  ..||| .| |||||
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdds..adflefvervrklrs.gkeePvvvhCsaGigrtGv

FCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIR
. .   ..| | . ..| . . |. .|  |. .|||.. | |  | | 
lilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 604-842 4.8e-54 178.2 In-house 21-264 (283) alignment
Range on Protein: 604-842
Range on HMM: 21-264/283.0
PASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYMK-----GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDK-GQSDKSCAQY
|  ..    . .|..|||. . .| ...|| |.|  .|||||...           .| .| ||  || ||| |||| | ..||||     . .. |.||
pdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

WPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKAS--HTVTQYQFHGWpkHGSDQQPGARSLMKLiRAVKSSTNKKKEFSILVHCLSGSGRTGVFC
||.. | ..| . |..    .    . ..| .  || |     .. ||. .|     ..|.   ||.|.   |.|  ...|.  |.||| .| |||.||.
WPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW..leygeqaiinslvkf.nkvislqteskkgPivvhCstgiGrtavfi

TAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
.|.  . ..     ||.|..|||.| .||  ||| . | . .|.. |
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 605-845 1.1e-52 174.3 In-house 15-257 (284) alignment
Range on Protein: 605-845
Range on HMM: 15-257/284.0
ASQTRSgRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNdkgqsDKSCAQYW
. || .   ..|. |||.|. |. ..|.| |.  .     ||||||...|      .|.|| ||. |. ||| |..... ||||.|      .. |.|||
tdqtfa.nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsqyw

PNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN--SKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKK-EFSILVHCLSGSGRTGVFC
|..   | . . |.. | .   . . |.......   |   ...|. | |||..|  ..|    ||.|.. |.  |.|.. . .|.||| .|.|||||. 
plkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdyp..sdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

TAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE-YLH
.    . .. | . ||....|. || .| ..||   .| | |  . | .| 
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf

subfamily_PTPN14_pd Subfamily PTPN14 605-845 7.2e-45 148.2 In-house 38-297 (300) alignment
Range on Protein: 605-845
Range on HMM: 38-297/300.0
ASQTRSGRTPDNQPKNRYGNNLPLERNRVILDSS---DHDYINASYMK----GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDK-GQSDKSCAQ
 ... ... |.|..|||. . || | ||| | ..   ...||||| .|    | . ..|..| ||..|| ||| ||.. . . |||| ..  .  . . .
dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPND----DSAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQQP-GARSLMKLIRAVKSSTNKKK-----EFSILVHCL
|.|..    ....|| . |.   ... . |.|..||.    ||   ||   |.  ||.||  . . |  | .. ...|.  ||...     .  .||||.
yfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

SGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
 | |||||  ..   || .  ....|| .....||  || .|||   | | |.|. .||.
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 606-847 2.7e-67 222.1 In-house 36-286 (305) alignment
Range on Protein: 606-847
Range on HMM: 36-286/305.0
SQTRSGRTPDNQPKNRYGNNLPLERNRVILDSS----DHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLN-DKGQSDKSCAQYW
...  |..  |. |||. .. .|. .|.||  .    |.|||||||..| .   ..|..| ||..||.||| .....|.||||||   . . .. | |||
esidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYW

PNDDSA--KFGSYSVSILSTSSDGDVTTRQLKVTR--NSKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVF
|.  .   .||..|| . |...  | ..|.||..   ..| |.||.|||.  || ||  |.  | ||..||. |. . .| |. ..||||  | ||||||
pesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf..atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvf

CTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTE
..    . .. . ..||.|. .| ||  ||. ||| ..| | .... |.... 
iavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

subfamily_PTPRA_pd Subfamily PTPRA 607-845 1.9e-58 192.9 In-house 49-297 (330) alignment
Range on Protein: 607-845
Range on HMM: 49-297/330.0
QTRSGRTPDNQPKNRYGNNLPLERNRVILDSS----DHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQYWP
        .|. |||. | || . .||||       . ||||||...| .   .||..| |.  || ||| |....| .||||| . | . .. ||||||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

NDDSAKFGSYSVSILSTSSDGDVTTRQLKVT-----RNSKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKKEfSILVHCLSGSGRTGVF
.. .  .|   |..  .    |.| |.. |.     .. |.|  |.|. |..||. |   .|  . ..||...||.  ... . .| ||| .| |||| |
deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep..iGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtf

CTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREY-LH
..    ....     ||.|..|| ||. | | |||.| | | |.|..|| |.
ivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly

subfamily_PTPN1_pd Subfamily PTPN1 607-842 1.1e-42 140.7 In-house 23-269 (290) alignment
Range on Protein: 607-842
Range on HMM: 23-269/290.0
QTRSGRTPDNQPKNRYGNNLPLERNRVILDSSDHDYINASYM--KGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKG-QSDKSCAQYWPNDDS
.||. ..| |...||| .  | .  |..|...| |||||| .  . ..  .| || ||| ||. || ||.. |  ..||||    ..   ||||||....
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

---AKFG--SYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPKHGSDQQPGArsLMKLIRAVKSSTNKKKE-FSILVHCLSGSGRTGVFCT
    ..   ...| ..|. .    | |.|...  ... ....... .  ||  |  . |.|  ..|..  |..|   ...    ..|| .| ||.| || 
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaa..flkflfkvresGslssdvGpavihcsaGiGrsGtfcl

AMECIAQIAEGDS---VDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
.  |...| . |    ||| ...  ||  |. ..|| .   |.|  | |
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_eak_pd Subfamily eak 608-848 1.1e-18 61.7 In-house 44-309 (332) alignment
Range on Protein: 608-848
Range on HMM: 44-309/332.0
TRSGRTPDNQPKNRYGnNLPLERNRVILDSSDH---DYINASYMK--GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPND
 . ..  ..  .| ..  .| .|. | | ||      ||||| ..   |   .| | ..  . |  || ||.. |  .||.| .. . . .   .|.|..
isetarleavnrnvvk.ivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

D--SAKFGSYSVSILSTSSDGDVTTRQLKVTRnSKASHTVTQYQFHGWPKHGS------------DQQPGARSLMKLIRAVKSSTNKKK-----EFSILV
     ||| . |   .    . . ||.|....    .| |  |...|| .                .. |.  |.    |. ||| ||       |. ..
treelkfGildverkefvkrniletrllelsk.GnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii

HCLSGSGRTGVFCTAMECIaQIAEGD---SVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
 .  || |.|||      | .. ..    .  . . .   .  |.  | .. ...| ||.. .|| . |
qsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 609-845 1.5e-49 163.6 In-house 21-269 (274) alignment
Range on Protein: 609-845
Range on HMM: 21-269/274.0
RSGRTPDNQPKNRYGNNLPLERNRVIL-----DSSDHDYINASYMKGVH---CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWP
.  . . .| |||| . || |. ||.|     ...| .|||| |.|| .    ... || |||.||.||| |..  . . |||| .  ....  ||.|.|
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

NDDSA----KFGSYSVSILSTSSDGDVTTRQLKVTRNSKaSHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNKKKEF--SILVHCLSGSGRTGV
.. ..    ..|  .. . .. .  | . |.| .   .. ...|. | .  || | | ..  |..|..|.. |..| .....   ...||| .| ||||.
daedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPdd..antlldlvleveesreeenaklapvvvhCsaGiGrtGc

FCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLH
| ..  .. |. |   ||....|  || ||   |||.| | . .... .||.
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

0040439 (Phosphotyrosine protein) phosphatases II 610-844 1.2e-59 197.3 In-house 5-246 (249) alignment
Range on Protein: 610-844
Range on HMM: 5-246/249.0
SGRTPDNQPKNRYGNNLPLERNRVILDS----SDHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPNDD
 .. | |..|||| . ||....||.| .     ..|||||||..|     .|| || ||| ||.||| |... . ..||||..  .   . ||||||...
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplgg

SAKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPkhGSDQQPGARSLMKLIRAVKSSTNKK-KEFSILVHCLSGSGRTGVFCTAMEC
| ..| ..|  ||. . .|.|.|.|..|.   . |.||...|...||    .  |   .|...|.||..  ..  |.  .||||  | ||||.|..|  .
sleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
. |. .   ||....|| ||  |.. ||..| | | ||...|.|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0049772 (Phosphotyrosine protein) phosphatases II 610-845 4.5e-33 110.7 In-house 40-281 (314) alignment
Range on Protein: 610-845
Range on HMM: 40-281/314.0
SGRTPDNQPKNRYGNNLPLErNRVILDS---SDHDYINASYMKGVhCTFITTQMPLPTTVSDF----------WSMVF--DFKPSTIVM-----------
 .. . |. |||| . || . |||||..   |..|||||||..|. ..|| || ||. || ||          |.||.  |... .|||           
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LND---KGqsdkscaqywP---NDDSAKFGsysvsilstssdgdvttrqLKVTRNSKASHTVTQYQFHGWPKHGSDQQPGARSLMKLIRA
          |..   .|          .     | . .                      .. ... .... .|  . .| .. .     ......|..
rLdaAlgKtpllildgng..........neptaadlellk...................eelydpelferlgikylripvpDgsaplledfdeflefiee

VksstnkKKEFSILVHCLSGSGRTGVFCTAMECIAQIaegdSVDIFQTVKILRADRM-----QFVQTEEEYAFTYEVIREYLH
.      .|.  .|||| .| ||||.|..|. .. .      |.. .... .|. |.      |... |.| | .|...||| 
a......dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 610-752 2.3e-20 67.7 In-house 27-179 (297) alignment
Range on Protein: 610-752
Range on HMM: 27-179/297.0
SGRTPDNQPKNRYGNNLPLERNRVILDS--SDHDYINASYMK----GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPNDD
| . .    |||| . |  . .|| |    ...||||| |.          .| .| || .|| ||| .|..    .|||.    .   . || |||. .
sakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

S--AKFGSYSVSILSTSSDG--DVTTRQLKVTRNsKASHTVTQYQFHGWPKHGS
    | |.. |  ||. ||    |   .|..    . |  |.  || .|| || 
qerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 611-846 8.4e-67 220.0 In-house 4-244 (250) alignment
Range on Protein: 611-846
Range on HMM: 4-244/250.0
GRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDKSCAQYWPNDDSA
.. |.|. |||| . ..|.  ||.| ...     ||||||...| .   .||.|| ||..|. ||| ||.. | .|||||..  .|.| . |||| . . 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

KFGSYSVSILSTSSDGDVTTRQLKVTRNSKASH-TVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQ
|.|.  ||.||.   .|.|.|.||.....||.. .| |..|  ||  |  ..  |.. ..|.. |..| .. ..  ..|.| .| ||.| |..    . .
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPev..atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

IAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
. .   ||.|. .|.||.||.. |...| | | ||.| ..| .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

0042113 (Phosphotyrosine protein) phosphatases II 611-844 2e-59 196.3 In-house 4-243 (245) alignment
Range on Protein: 611-844
Range on HMM: 4-243/245.0
GRTPDNQPKNRYGNNLPLERNRVILDSSD----HDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPNDDS
.. | |..|||| . ||....||.| . .    .|||||||..|     .|| || ||| || ||| |... . .|||||..    . . ||||||...|
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

AKFGSYSVSILSTSSDGDVTTRQLKVTR-NSKASHTVTQYQFHGWPkhgSDQQPG-ARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECI
 ..| ..|  ||. ...|.|.|.|.||.  .. |..|..|....||    .. |   ..| .....|..  .....  .||||  | ||||.|..|  ..
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp...dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
 |. .   |.....|| ||  |.. |||.. | | ||...|.|
eqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 611-844 1.3e-56 187.2 In-house 5-242 (243) alignment
Range on Protein: 611-844
Range on HMM: 5-242/243.0
GRTPDNQPKNRYGNNLPLERNRVILdsSDHDYINASYMKGVHcTFITTQMPLPTTVSD----FWSMVFDFKPSTIVMLNDKG-QSDKSCAQYWPndDSAK
.. | |..|||| . ||....||.|  ...|||||......  ..| ||.||| || |    || |... . ..||||..    . . ||||||  ..  
allpenlsknrysdilpydhsrvkl..egsdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevt

FGSYSVSILSTSSDGDVTTRQLKVTR--NSKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNK-------KKEFSILVHCLSGSGRTGVFCT
.| ..| .||... .|.| | |....   .. ...|..|....|| ||  .     .|......|..  ..       ...  .||||  | ||||....
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPds..pedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

AMECIAQIaegdSVDIFQTVKILRADRMQ-FVQTEEEYAFTYEVIREYL
|  .. ..    .||....|| ||. |..  |||.. | | ||...|.|
aylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 611-842 3.7e-50 165.7 In-house 44-277 (315) alignment
Range on Protein: 611-842
Range on HMM: 44-277/315.0
GRTPDNQPKNRYGNNLPLERNRVIL----DSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDKSCAQ-YWPNDdS
 .   |. |||| | .. .. || |      .. ||.||....|      .|..| |....| ||| .||. . ..||||..  . .|. |. |||..  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

AKFGSYSVSILSTSSDGDVTTRQLKVTRNSKAsHTVTQYQFHGWPKHGSdqQPGARSLMKLIRAVKSSTNKKKeFSILVHCLSGSGRTGVFCTAMECIAQ
  .| ..|.  |     ..| | | |. ...  ..| |...  ||. |      . .||.||| ||   ...   .|.||| .| |||| |.|    . |
viyGkitvtrkseevnteytvrtlsvvfgdni.revvqlhytswpdmgv..pkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldq

IAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
.   . .|... .. .|. |.. ||. |.| | |... |
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle

subfamily_PTPRK_pd Subfamily PTPRK 612-842 3.5e-61 201.8 In-house 39-275 (314) alignment
Range on Protein: 612-842
Range on HMM: 39-275/314.0
RTPDNQPKNRYGNNLPLERNRVILDSSDHD----YINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQ-SDKSCAQYWPNDDSA
.  .|. |||.|. |. .| ||.| . | |    ||||... . .    || || ||. || ||| .|.| . ..||||..  . .   | .|||.| . 
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

kFGSYSVSILSTSSDGDVTTRQLKVTR---NSKASHTVTQYQFHGWPKHgsDQQPGARSLMKLIRAVKSSTNKkKEFSILVHCLSGSGRTGVFCTAMECI
 .|   | ...|. . .. .| ..|..   . .. ..| |.|| |||.|  |    |..|.||.| ||.|... ..  |.|||..|.||||.|..    .
.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh..dvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl

AQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIRE
  | . . ||.|..|| ||. .. .|.||| | | |.|| |
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 612-846 2.3e-24 80.7 In-house 44-289 (305) alignment
Range on Protein: 612-846
Range on HMM: 44-289/305.0
RTPDNQPKNRYGNNLPLERNRVILDSS-DHDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVML-NDKGQSDKSCAQYWPNDDSA---
.  ... |||| .   |..||| |...  |.|| | |.        || || ||  | .||| | .. |  .| || | . .  | |..|.. .|     
keaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

----------KFGSYSVSILSTSSDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSStnkKKefSILVHCLSGSGRTGVF
          || | .   . .... .||  .| .    . .. ||.| .  ||  |        ....|.   ..|   |    | ||| .| ||||  
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa..adlailellekarps...kg..pivvhcsagigrtgsv

CTAMECIAQIAEGDSVDIFQ-TVKILRADRMQFVQTEEEYAFTYEVIREYLHT
      . |. .|. ..  .  .. .| .| . .||...| | ..|| .|.. 
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

subfamily_CG42327_pd Subfamily CG42327 613-771 1.9e-19 64.5 In-house 25-193 (319) alignment
Range on Protein: 613-771
Range on HMM: 25-193/319.0
TPDNQPKNRYGNNLPLERNRVILDSS----DHDYINASYMKGV---HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPND---
 .  ..|.|. | .||   ||.|..        |..|||..|    .. .|..|..|  . |||| .|.. .  .|| | |  .   | ||.|.|     
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

-DSAKFGSYSVSILSTSSDGDVTTRQLKVTRN-SKASHTVTQYQFhGWPKHGSDQQPGArsLMKLIRAVKSS
 .   .| . |..    ..    .  | . |   . |  .| | .  |.. .   .. |  |. ..  |.||
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaa..liamllevrss

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 615-841 1.1e-40 134.4 In-house 2-236 (237) alignment
Range on Protein: 615-841
Range on HMM: 2-236/237.0
DNQPKNRYGNNLPLERNRVILD--SSDHDYINASYMKGVHC---TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQ-SDKSCAQYWPNDD-SAKFG
.|. ||||||    . .||.|    |. |||||.|.||.     ..|..| || ..  ||| ||.. | | ||||    .  .. | .|||. |  | .|
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SYSVSILSTSSDGDVTTRQLKVTRNS--KASHTVTQYQFHGWPKHGSDQQPGArsLMKLIRA-VKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQI
 ..||.       | | | | ....   |    . ||||  ||..|  ||  |  |... .  .. |    .    ..|| .| ||||.|      . | 
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaa..llrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIR
 |   |||.. |. .  ||   .||...| | ...| 
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 615-853 8.3e-19 62.3 In-house 46-288 (303) alignment
Range on Protein: 615-853
Range on HMM: 46-288/303.0
DNQPKNRYGNNLPLERNRVILdsSDHDYINASYMK-GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDKSCAQY-W-PNDDSAKFGSYSV
.|  |||. . . |.  .| |  ||  || |||..   .   | ||.||. | .||| |. . |   ...|   .. ||   .. .  |.|  ||   |.
knmdknrfvdvicldhskvkl..sdssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersi

SILSTSSDGDVTTRQLKVTRNSKASH--TVTQYQFHGWPkHGSDQQPGARSLMKLIRAVKSSTNKKKEFSILV-HCLSGSGRTGVFCTAM-ECIAQIAEG
 .        .   .|||   |. ..   .  .... || |.|    |.  ..| |  ..|   |  . .  |   ||| ||.| |.      ..  .| 
rvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawp.hnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseq

DSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYEQLP
 |.|. . .. .|  |.. ||   .... | .. |..  . . .| 
asldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickla

Y_phosphatase Protein-tyrosine phosphatase 616-840 2.5e-66 218.9 Pfam-A 1-233 (235) alignment
Range on Protein: 616-840
Range on HMM: 1-233/235.0
NQPKNRYGNNLPLERNRVIL-DSSD-HDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWP--NDDSAKFGS
|. |||| . || ...|| | .|.. .|||||.|.||   . .|| ||.||. |..||| ||.. | ..||||..  .. .. ||||||  ...| ..|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVSIL-STS-SDGDVTTRQLKVTRNSKA--SHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTnKKKEFSILVHCLSGSGRTGVFCTAMECIAQI
..| .  ...  . ..|.|.|... . .   ...|.|.....||.||  ..  ..||..|||.|..|. ..|. ...|||  |.||||.|.... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVI
 ....||..|.|| ||. |.. ||..|.|.| |..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 616-840 2.5e-66 218.9 In-house 1-233 (235) alignment
Range on Protein: 616-840
Range on HMM: 1-233/235.0
NQPKNRYGNNLPLERNRVIL-DSSD-HDYINASYMKGV--HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWP--NDDSAKFGS
|. |||| . || ...|| | .|.. .|||||.|.||   . .|| ||.||. |..||| ||.. | ..||||..  .. .. ||||||  ...| ..|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YSVSIL-STS-SDGDVTTRQLKVTRNSKA--SHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTnKKKEFSILVHCLSGSGRTGVFCTAMECIAQI
..| .  ...  . ..|.|.|... . .   ...|.|.....||.||  ..  ..||..|||.|..|. ..|. ...|||  |.||||.|.... .. |.
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes..pkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVI
 ....||..|.|| ||. |.. ||..|.|.| |..|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykai

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 616-847 2.1e-46 153.1 In-house 20-267 (270) alignment
Range on Protein: 616-847
Range on HMM: 20-267/270.0
NQPKNRYGNNLPLERNRVILDSSDH----DYINASYMKG---VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQYWPNDDSA---
..  ||| . ||  . ||.|.. ..     |||| |..|    ....|... |||||...|| |... | ..|||. . . .  | |..|||..      
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

-KFGSYSVSILSTSSDGDVTTRQLKVTRNSKAsHTVTQYQFHGWPKHGSDQQPG----ARSLMKLIRAVKSSTNKKKE-FSILVHCLSGSGRTGVFCTAM
 ..|  .|  ||.. .    ...|.......  . .. .... || ||  ....    ...|.|..|||. |......   .||||  | ||||.. .  
ledgkikvlalseekeegyiltrlrleekgee.rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

ECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTE
 ..  . |  .||. . .. || |||..||. |.|.| |....|| .. 
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

0041856 (Phosphotyrosine protein) phosphatases II 616-849 2.2e-38 127.0 In-house 1-176 (182) alignment
Range on Protein: 616-849
Range on HMM: 1-176/182.0
NQPKNRYGNNLPLERNRvildssDHDYINASYMKGVHCT--FITTQMPLPTTVSDFWSMVFDFKPSTIVMLNdkgqsdksCAQYWPnddsakfgsysvsi
|..|||| . || ...|      | |||||... | . .  || || ||. || ||. |. . . .|||.|.        . .|||              
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..............

lstssdgdvttrqlkvtrnSKASHTVTQYQFHGWPKHGSDQqpgARSLMKLIRAVKSstnkkKEFSILVHCLSGSGRTGVFCTAMECIAQiaegdSVDIF
                   ..  ....||....|| ||       ..| ..|..|..     ..  .||||  | ||||... |  .. .     .|...
...................ellerlgiqylylpwpDhgvpd...ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

QTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENY
..|| .|  |.. |.|.. | | . ...|.|.  ..
eavklvrsrRpgmvitpnqyfflqlallellllkkt

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 616-847 3.4e-32 106.5 In-house 35-273 (285) alignment
Range on Protein: 616-847
Range on HMM: 35-273/285.0
NQPKNRYGNNLPLERNRVILDSSDHDYINASYMKG---VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPND--DSAKFGSY
|   ||| .   .|  ||.|   |.||| ||.|.     . |.|||| ||| |.|||| |... | . ..||    .   . || |.|.   .  ||| |
npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

SVSILSTSSDGDVTT--RQLKVTRNSKASHT---VTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSSTNkkKEFSILVHCLSGSGRTGVFCTAMECIAQI
 ...     .    |    | |.    ||     . . |   || . . .   || ...| . ||      ||  | ||| .| |||  |     .  .|
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlape..darpmielykwvkkvnp..kekpicvhcsagvgrtatfvgidyatiri

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTE
 |   ..... |. .|| |.| ||.  .. | | |. ||.  |
menpniemldivremramrfqavqshmqflflyvvlmeyfige

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 616-838 5.5e-32 105.8 In-house 7-234 (239) alignment
Range on Protein: 616-838
Range on HMM: 7-234/239.0
NQPKNRYGNNLPLERNRVILDS----SDHDYINASYMK---GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPnDDSAKFG
|. |||| | .  ...||.|.        |||||||..   |   ..|.||  . ..  ||| |... .   ||||    .   | | |||| | ..|. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

SYSVSILSTSSDGDVTTRQLKVTRNSKAS-HTVTQYQFHGWPKHGSDQQpgARSLMKLIRAV-KSSTNKKKEFsiLVHCLSGSGRTGVFCTAMECIAQIA
   |..  |    |   | . ...  ..  . | ||.|  || .|  |   | ... | | . | |    . .  ..|| .| |||| |      . |  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpw..vihcsagvgrtgaflvidamlrqak

EGDSVDIFQTVKILRADRMQFVQTEEEYAFTYE
.  .||||. || .| || ..||| |.| | . 
kqktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 616-838 5.7e-32 105.8 In-house 8-235 (239) alignment
Range on Protein: 616-838
Range on HMM: 8-235/239.0
NQPKNRYGNNLPLERNRVILDS----SDHDYINASYMK---GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPnDDSAKFG
|. |||| | .  ...||.|.        |||||||..   |   ..|.||  . ..  ||| |... .   ||||    .   | | |||| | ..|. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

SYSVSILSTSSDGDVTTRQLKVTRNSKAS-HTVTQYQFHGWPKHGSDQQpgARSLMKLIRAV-KSSTNKKKEFsiLVHCLSGSGRTGVFCTAMECIAQIA
   |..  |    |   | . ...  ..  . | ||.|  || .|  |   | ... | | . | |    . .  ..|| .| |||| |      . |  
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqy..atavlglrrkitkdslpgarpw..vihcsagvgrtgaflvidamlrqak

EGDSVDIFQTVKILRADRMQFVQTEEEYAFTYE
.  .||||. || .| || ..||| |.| | . 
kqktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 616-851 5.4e-23 76.4 In-house 43-278 (288) alignment
Range on Protein: 616-851
Range on HMM: 43-278/288.0
NQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVHC--TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQ-SDKSCAQYWPND--DSAKFGSYS
|  ..|| |    .  || |.   . ||.|  .   .    .| .| || .|.  .| |...     ||||..  .   .  |.|.|    ..|..| . 
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlc

VSILSTSSDGD--VTTRQLKVTRNSKASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNkkkefSILVHCLSGSGRTGVFCTAMECIAQIAEGD
  .    .| |  |.   |..... . .  | .  .. |...|  ..    | ..|.  .|| ..      |.||.  |.|||| .   .  . ..   |
tvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen..ylsplrllevlkslqk.....PivvhssaGvGrtgtlililialeslrldd

SVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYEQ
 . | . .. ||..|.. .|||  | . . .. |.|    |..
flgirsllaklreerfkaiqtemqylyvhrcvleelllkkykv

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 616-846 5.7e-19 62.6 In-house 51-287 (302) alignment
Range on Protein: 616-846
Range on HMM: 51-287/302.0
NQPKNRYGNNLPLERNRVILDSSDHDYINASYMKGVHC--TFITTQMPLPTTV---SDFWSMVFDFKPSTIVMLNDKGQSDKSCAQYWP--NDDSAKFGS
|  ||.  .   |. |.|.|. .  .|.||| ..  ..  . | .|.|  ...    .|| |||. |  ..|.|  . . .|.  ...|   .|  ..|.
nlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygk

YSVSILSTSSDGDVT-TRQLKVTRNSKA-SHTVTQYQFHGWPKHGSDQQPGarSLMKLIRAVkSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAE
  | .   ..  . .    . |  .  . |  .. | .. |...   .. .  .|.| .  |    . | . ....    |.|| |.| |..  . .. .
mfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya..eliktaakv.fakkikadentvivSknGaGRagafltlavaveklqk

GDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
|. . | ..|| .|..| . |.. . |...| ..  |. .
gkepnikeivksiRsqRpravdslkQyvslyialllyikk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 616-839 4.3e-18 59.9 In-house 52-285 (310) alignment
Range on Protein: 616-839
Range on HMM: 52-285/310.0
NQPKNRYGNNLPLERNRVIL--D-SSDHDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPNDDS-AKFGS
.  |||| . . |.  || |  | |  .||| | |.|   .  ||| .| ||  |. ||| |.|. .  .|..|   |.  .  |  |||       .| 
ymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygc

YSVSILSTSSDGdVTTRQLKVTR-------NS-KA---SHTVTQYQFHGWPKHGSDQQPGARSLMKLIRAVKSStnkkkefSILVHCLSGSGRTGVFCTA
  |. || ||.      .| ||        .   |      |.  ..  ||  |  ..       .|.  |.           .||| .| .|..| .. 
irvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhg.......pcvvhcsagkdrlyvvval

MECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEV
   | .. .|. ||. . .  |. .|.. .||| .| .   |
klkidkldrglkvdaeevktellksraiciqtelqyliidrv

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 618-848 3.9e-20 66.8 In-house 45-280 (312) alignment
Range on Protein: 618-848
Range on HMM: 45-280/312.0
PKNRYGNNLPLERNRVILDSSDHDYINASYMKGVH--CTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKG-QSDKSCAQYWPN-------DDSAKFG
  ||| |    .| |  |   .  || | ..| .     |..|| ||  |.. || ... .  ..|..|     .. . ||.|  .       .|   . 
dlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyt

SYSVSI-LSTSSDGDVTTRQLKVTRNSK-ASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKsstN-KKkefSILVHCLSGSGRTGVFCTAMECIAQI
 |   | .   |   .| | |||  ..      . .||.  || ||  .     . ..|. |||   . ||    .. || .| |||| ..     || .
eycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpds..cdtalrllsavk...kdkk...pviahcsagvgrtgtlaliesmiaal

AEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTEN
      .. ..  .|| || . |..  .| ..  .. |.|... 
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 618-702 4.1e-16 53.6 In-house 49-154 (350) alignment
Range on Protein: 618-702
Range on HMM: 49-154/350.0
PKNRYGNNLPLERNRVILD------------SSDHDYINASYMKGV------HCTF--ITTQMPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQ
 |||| | || |..||.|              |  |||||.|.|           |  | || ||| || ||. ...  |   |..|..   .  . | .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPNDD
||.. .
YWqegs

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 620-840 7e-24 79.5 In-house 23-255 (290) alignment
Range on Protein: 620-840
Range on HMM: 23-255/290.0
NRYGNNLpLERNRVILDSS----DHDYINASYMKGV-HCTFITTQMPLPT-------TVSDFWSMVFDFKPSTIVMLNDKGQSDK-----SCAQYWPN--
.|. . | .| .||.|         ||| |....      .| || |.         |. .|| |. . |   .||| .  . ..     .||.| |.  
qRlevpL.veatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesv

DDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKhgSDQQPGARSLMKLIRAVKsstnkKKEFSILVHCLSGSGRTGVFCTAMEC
... ||.  .|.  |   . || ||.| |. . .  .||| ....|| |  .  |.  ..|..||. ||     ...  ..|||  |  |  .. .    
geelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnk..lnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilg

IAQIA-EGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVI
   ||   .|| . . .| ||  | . .....|.||   .|
yQkiaetsgsvkledvlkalrkqralaitsalelafvdagi

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 626-752 2.7e-09 31.4 In-house 3-126 (130) alignment
Range on Protein: 626-752
Range on HMM: 3-126/130.0
LPLERNRVIldssDHDYINASYMK--GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDkscaQYWPndDSAKFGSYSVSILSTSSDGD--
|. | .|.     ...|||||..   |    .. || ||  |  ||| |...     .|.|    . |    .|||  ||  .  |   |. |..| |  
lefevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywp..dsePlewyeediivtltdrdef

--VTTRQLKVTRNSKASH-TVTQYQFHGWPKHGS
  . . .|.. .. . || ..| .|   ||  |.
knikasnleiesdlneshqaltmfqisnwpsdgt

0044763 (Phosphotyrosine protein) phosphatases II 627-844 3.6e-19 64.5 In-house 1-171 (178) alignment
Range on Protein: 627-844
Range on HMM: 1-171/178.0
PLERNRVILDSSDH----DYINASYMKGVhcTFITTQMPlpttvSDFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPNDDSakfgsysvsilstssdgd
||.|.||.|..  .    ||||||.. .    ..... |     .|.. .. . . ..||.|..       .| .||| . .                  
pldrtrvllsnleglersdyinaseilpg..lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

vttrqlkvtrnskashtvTQYQFHGWPKHGSDQqpGARSLMKLIRAVKSSTNkKKEFSILVHCLSGSGRTGVFCTAMECIAQiaegdSVDIFQTVKILRA
                   ||.. ..| ||  .    . ..........  . .|.  .||||  | ||.|... |  .. .     ...... .. .|.
..................iqylhipipDhgvpd..llehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvre

DRMqFVQTEEEYAFTYEVIREYL
 |. .|.... . . ||. ...|
rRp.ivpnpgqlrqLyefelrll

0046846 (Phosphotyrosine protein) phosphatases II 632-844 9.9e-29 95.7 In-house 4-173 (176) alignment
Range on Protein: 632-844
Range on HMM: 4-173/176.0
RVILDSSDHDYINASYMKGvhCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPNDDSAKFgsysvsilstssdgdvttrqlkvt
|.. .  | |||||... |  . .|.|| ||| |. ||. |... . ...|.|..  . .. .|..|||   ....                        
rllgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

rnskashtvtQYQFHGWPKHGSDQQpgaRSLMKLIRAVKSSTNKKkeFSILVHCLSGSGRTGVFCTAMeciaQIAEGDSVDIFQTVKILRADRM-QFVQT
          ||....|| ||  .    . |..|......  ...    .||||  | ||||... |      .  .  ........ .|. |. . |||
..........qylhlpwpDhgvpdl...elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

EEEYAFTYEVIREYL
.| | | ||.....|
peQyrflyefellll

subfamily_egg_pd Subfamily egg 636-842 1.9e-20 67.8 In-house 68-268 (307) alignment
Range on Protein: 636-842
Range on HMM: 68-268/307.0
DssdhDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSdKSCAQYWPN--DDSAKF--GSYSVSILSTSSDGD--VTTRQL
|    |.| | ..||  .  .|| .| ||  || ||| |||  .   ||||. . .| . |  |||.  .||...  ||. .  |   |  |   .  .|
d....dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvpGslrienlkvdskadplfrvtkl

KVTRNSKASHTVTQYQFHgWPKHGSDQQPgarslMKLIRAVKSSTNkkkefSILVHCLSGSGRTGVFCTAMECIAQIAEGDS--VDIFQTVKILRADRMQ
|.    .    .  .|   . . .    |     ....| ..  ..      ..|..  |  ..... ..   . ..  |      . ..|. ||  |  
klvGgddeerflehwqgd.vnnssdvysp.....lrvlrklrnlsk.....pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrl

FVQTEEEYAFTYEVIRE
 |..   | | | ..  
svesvllylfvyrlvlf

0043147 (Phosphotyrosine protein) phosphatases II 638-838 2.9e-28 94.1 In-house 3-155 (172) alignment
Range on Protein: 638-838
Range on HMM: 3-155/172.0
SDHDYINASYMKGVHCT--FITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKgqsdkscaqywpnddsakfgsysvsilstssdgdvttrqlkVTRNSKA
...|||||||.......  || || ||. |..||| |. . . ..||.|..                                          ..  .. 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpell

SHTVTQYQFHGWPKHGSDqqpGARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAF
.... ||....|| ||      .. |..... ...  .....  .||||  | ||||... |  ..       .......|. .|. |.. ||... | |
erlgiqylylpwpDhgvp...llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

TYE
 |.
lyy

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 639-701 2.1e-09 31.2 In-house 89-156 (349) alignment
Range on Protein: 639-701
Range on HMM: 89-156/349.0
DHDYINASYMK----GVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLN-DKGQSDKSCAQYWPND
 .||||| |.|     |.  .|.||.|||.|| ||. ..   .   .. || || .| . | .|| . 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 639-686 1.1e-07 25.8 In-house 69-118 (347) alignment
Range on Protein: 639-686
Range on HMM: 69-118/347.0
DHDYINASYMKG--VHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLND
 . |||||..|    .  .| || ||| || ||| ||.  | . .| . .
vetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife

0051429 (Phosphotyrosine protein) phosphatases II 640-846 5.5e-37 123.2 In-house 4-227 (272) alignment
Range on Protein: 640-846
Range on HMM: 4-227/272.0
HDYINASYMKGVhCT------FITTQMPLPTTVSDFWSMvFDFKPSTIVMLNDKGQSDK-SCAQYWP------------NDDSAKFGSYSVSILSTSSDG
 .||||....|  .       .. ...||| |. ||| .  . . .|||.| .    ..  | .|||             . .  .| ..| .||..   
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DVTTRQLKVTRN--SKASHTVTQYQFHGWPKHGSDQQPgARSLMKLIRAvksstnkkkEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVD-------
|.. | | .|.    .....|.......|| ||  |..  ..|..|...         .  .|||| .| .|||... .  ..... . . ||       
dyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
 ....|. ||| |...||||| |.| ||...|.| .
yleeaveelraqrpgavqteeqylflyeallellrs

0036282 (Phosphotyrosine protein) phosphatases II 640-838 2.2e-30 101.0 In-house 2-164 (174) alignment
Range on Protein: 640-838
Range on HMM: 2-164/174.0
HDYINASYMKGVHCT--FITTQMPLPttvsdFWSMVFDFKPSTIVMLNDKGQSD-KSCAQYWPNddsakfgsysvsilstssdgdvttrqlkvtRNSKAS
.||||||.......|  .| .| ||.     || |..... .|.|||..  . .   | .|||                               . .  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

HTVTQYQFHGWPKHGSDQQPGarsLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAeGDSVDIFQTVKILRADRMQFVQTEEEYAFT
... ||.. .|| ||    .    | .....|..  .....  .||||  | ||||... |. .. ..   . ||....|. ||  |.. |||.. | | 
rlgiqylylpwpDhgvpdlsi...llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

YE
|.
yy

0051082 (Phosphotyrosine protein) phosphatases II 640-840 6.7e-26 86.1 In-house 3-149 (151) alignment
Range on Protein: 640-840
Range on HMM: 3-149/151.0
HDYINASYMKGVhctFITTQMPLPttvsDFWSMVFDFKPSTIVMLNDKGQSDkSCAQYWPNDDsakfgsysvsilstssdgdvttrqlkvtrnskasHTV
 ||||.||. |    .. ...||.    ||. .. . . .|||.|...   .  |..|.|. .                                  ..|
sdyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg..................................iev

TQYQFHGWPKHGSDQQ-PGARSLMKLIRAvksstnkKKEFSILVHCLSGSGRTGVFCTAMECIAQiaegdsVDIFQTVKILRADRMQFVQTEEEYAFTYE
.......|| .| ..  . ......|...       ||.  .|||| .| ||||... .. .. .      |....... .|. |. .||..... | . 
lhipildwpdpglplsfdavleflellld.......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

VI
..
al

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 649-833 2.8e-25 83.7 In-house 86-270 (301) alignment
Range on Protein: 649-833
Range on HMM: 86-270/301.0
KGVHCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKG-QSDKSCAQYWPNDDS--AKFGSYSVSILSTSS--DGDVTTRQLKVTRNSK--ASHTVTQ
.|    ||.|| ||. |  ||| |.  ..  .||||  |  .  . |..| | . |   . | ... | .. .  . ... |.|.|.  ..  |..||| 
sGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvth

YQFHGWPKHGSDQqpGARSLMKLIRAVKSSTNkkkefSILVHCLSGSGRTGVFCtAMECIAQIAEGD-SVDIFQTVKILRADRMQFVQTEEEY
||.. |...|  .  .   |..|.  || | .      |.||| .| ||.  |  . |..|.  | |  ... ...| || .| . |||..  
yqysewtdrgvPk..shaelfdlmelvkksek.....PivvhcsaGiGrsvafi.gteylareveadptieltealkhlrehrwngvqtnsql

0049260 (Phosphotyrosine protein) phosphatases II 652-838 4.1e-24 80.4 In-house 8-144 (152) alignment
Range on Protein: 652-838
Range on HMM: 8-144/152.0
HCTFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWpnddsakfgsysvsilstssdgdvttrqlkvtrnskashtvtQYQFHGWPKH
.  || || |.| |..||| |. . . .|||||..    .|  |.||.                                          ||... || |
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GSDQQPGARSLMKLIRAVKsstNKKKEFSILVHCLSGSGRTGVFCTAMECIaqiaegDSVDIFQTVKILRADRMQFVQTEEEYAFTYE
|  . .     . |.       ...|.  .||||  | ||||... |  ..        |.....|. .|. |.. |.... . | ||
gvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 654-841 9.7e-35 114.7 In-house 237-435 (440) alignment
Range on Protein: 654-841
Range on HMM: 237-435/440.0
TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKgqSDKSCAQYWP-NDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRNsKASHTVTQYQFHGWPKH--
.||.||||| .|| ||| .| |.. |||.|||.    ||.|. ||| |  |  || ..|    .     |  | |..  . .  | . |..   ||    
afiatqmpldstvldfwrlvhdyristiimlnql..ndktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk.eevheirqfevqtwptwiq

--GSDQQP----GARSLMKLIRA--VKSSTNKKK---EFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEV
  | . |         ||  .|   .. ||.. .      ||||||||   .||||| |.|. |. .  ..|.|| ...||  | .|| |  .| . | .
sdgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykl

IR
. 
lt

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 654-839 3.1e-22 73.7 In-house 5-198 (198) alignment
Range on Protein: 654-839
Range on HMM: 5-198/198.0
TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPNDDS--AKFGSYSVSILSTSSDGDVTTRQLKVTRNSKAS---HTVTQYQFHGW
 .|.|| ||  |..||| ||..     |||.||  .  .   . |||  .|  .|.|| ||.  . ..  | |   | .| |. |      ...|||  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHGSDQQPGARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFTYEV
 .. . .      ..   | |    ...|.  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | | |.|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 654-839 3.3e-22 73.6 In-house 6-199 (199) alignment
Range on Protein: 654-839
Range on HMM: 6-199/199.0
TFITTQMPLPTTVSDFWSMVFDFKPSTIVMLNDKGQSDK-SCAQYWPNDDS--AKFGSYSVSILSTSSDGDVTTRQLKVTRNSKAS---HTVTQYQFHGW
 .|.|| ||  |..||| ||..     |||.||  .  .   . |||  .|  .|.|| ||.  . ..  | |   | .| |. |      ...|||  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PKHGSDQQPGARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFTYEV
 .. . .      ..   | |    ...|.  ..|||  | | |||| .    .    |     ||.|.  | ||  |   . . . | | |.|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 659-844 3.9e-10 32.9 In-house 124-309 (346) alignment
Range on Protein: 659-844
Range on HMM: 124-309/346.0
QMPLPTTVSDFWSMVFDFKPSTIV-MLNDKGqsDKSCAQYWPNDDSAKF---GSYSVSILSTSSDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKHgSDQ
||   . | ||| |... .   .  |. |     |  .    ||.   .   |   .    .   ||     ..|  . ..   . | . |   ||  .|
qmenesfvedfwymiyqeqihlvylmvpddk..lkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkh.lqq

QPGARSLMKLIRAVKSStNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
 | .  ..|.|   .|  .. ..  . |  | |.||.  |  |.  | |. .|   .|.. .| .. .|   |..  .||  | .. .|.
ppktlpiikmihqflse.kqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 660-834 2.9e-14 47.2 In-house 98-278 (302) alignment
Range on Protein: 660-834
Range on HMM: 98-278/302.0
MPLPTTVSDFWSMVFDFKPSTIVMLND-KGQSDKSCAQYWPND--DSAKFGSYSVSILSTSSDGDVTTRQ-------LKVT---RNSKASHTVTQYQFHG
.|   |.  .|... ... . .| | . . . .| ||.|. ..  .  ||| |.|  .|   | .  | .       ....   ...|  .||   .| .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPKHGSDQQPgaRSLMKLIRAVKSStnKKkefSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
||.||. ...   . .....  .|   ||   ..||||  | |||| . .    |   .. .  |. . |. .|. |   ||.|.   
wpdhGapkea..ytaldilkfcesy..kk...nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

subfamily_hpo-7_pd Subfamily hpo-7 663-841 2.7e-18 60.8 In-house 44-224 (263) alignment
Range on Protein: 663-841
Range on HMM: 44-224/263.0
PTTVSDFWSMVFDFKPSTIVMLNDKGQS-DKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTR---NSKASHTVTQYQFHGWPKHGSDQQpgA
  |.  |....   |....||| |      . | .|.| .   |     |.. .| .  ||  . |...    . |  |||..|.. ||...   ..  |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpel..a

RSLMKLIRAVKSStnKkkefSILVHCLSGSGRTGVFCTAmECIAQ-----IAEG--DSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIR
|. ........ |  |    |. ||| .| ||.  |  | | . |     . .     .|  . .. ||  | . ..|    ||.  .. 
reilnilkvarns..k....slvvhcstGiGrsaafsva.ElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 665-846 4.2e-20 66.9 In-house 40-223 (255) alignment
Range on Protein: 665-846
Range on HMM: 40-223/255.0
TVSDFWSMVFDFKPSTIVMLNDKGQ-SDKSCAQYWPNDDSAKFGSYSVSILSTSSDGDVTTRQLKVTRN---SKASHTVTQYQFHGWPKHGSDQQpgARS
||  |. ..   |....||| |  . . . | .|.| .   |     |.. .| |  ||  | |..| .    |  |||. |...||... . ..  || 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel..are

LMKLIRAVKSStnKkkefSILVHCLSGSGRTGVFCTAmECIAQ-----IAE--GDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHT
.......|. |  |    |..||| .| ||.  |  | | . |     . .     .|  . .. ||  | . ..|  . ||.  .. .... 
ilnilkvvrds..k....svvvhCstGiGrsaafvla.elvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfp

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 711-851 8.7e-95 312.4 In-house 252-392 (392) alignment
Range on Protein: 711-851
Range on HMM: 252-392/392.0
VSILSTSSDGDVTTRQLKVTRNSKASHTVTQYQFHGWPKHGSDQQPGARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSV
...|||||||||...|||..|..||||||||||||||||||||||.|||||.|||||||.|||.|||||||||||||.||||||||||||||||||||||
lqdlstssdGdvrskqlkefrslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsv

DIFQTVKILRADRMQFVQTEEEYAFTYEVIREYLHTENYEQ
|||||||||||||||||||||||||.|.|||||||||.|||
difqtvkilradrmqfvqteeeyafvydvireylhtekyeq

PTPc_motif_SM00404 727-797 5.5e-06 21.3 In-house 32-100 (140) alignment
Range on Protein: 727-797
Range on HMM: 32-100/140.0
LKVTRNSKASHTVTQYQFHGWPKHGSDQQPGARSLMKLIRAVKSStnKKKEFSILVHCLSGSGRTGVFCTA
..||.. ...    ..|.   | . ..... .. | |... ....  .||. ..||||  |  |.. ...|
invteevsltkensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliia

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 732-844 1.8e-06 21.5 In-house 213-344 (349) alignment
Range on Protein: 732-844
Range on HMM: 213-344/349.0
NSKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIR-------AVKS--STNKKKEFSILVHCLSGSGRTGVFCTAMECIA--QIAEGDSVD---------
...  . . | |.  |.  .    |   |... .           .    ....  ..|||| .| |||||..|    ..  .  . .|.          
avekPyellqlqvknwldlslllnP..isilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkD

-IFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
 |. .| .||  |.. ||   .. . || . .|.
lisiivnelrkqrismvqnlaqfiaiyealLkyf

0048076 (Phosphotyrosine protein) phosphatases II 733-843 9.2e-15 50.1 In-house 41-142 (145) alignment
Range on Protein: 733-843
Range on HMM: 41-142/145.0
SKASHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKkeFSILVHCLSGSGRTGVFCTAMECIAqiaegDSVDIFQTVKILRADRMQFVQTEEE
.  .....||.. .|| ||  . .  . |.........  ...    .||||  | ||||... |. ..       .|....... .|. |...|.... 
ellerlgiqylylpwpDhgvpdll..ellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgq

YAFTYEVIREY
. | ||...|.
lrflyefelel

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 735-848 1.1e-52 173.8 In-house 170-280 (515) alignment
Range on Protein: 735-848
Range on HMM: 170-280/515.0
ASHTVTQYQFHGWPKHGSDQQpgARSLMKLIRAVKSSTNKKKeFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYA
 |.||||..|..||..|....  ..||.|||..||..... . .....||..| |||||........|.......||.|..|...|..|...|||.|.||
dsrtvtqfhfteWPdkGvpkh..tssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqya

FTYEVIREYLHTEN
| |....|.|.  |
fiygavledllwrn

0048179 (Phosphotyrosine protein) phosphatases II 736-838 8.7e-14 46.9 In-house 46-139 (144) alignment
Range on Protein: 736-838
Range on HMM: 46-139/144.0
SHTVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNkkKEFSILVHCLSGSGRTGVFCTAMECIaqiAEGdsVDIFQTVKILRADRMQFVQTEEEYAF
 ....||.. .|| ||  . .    | ........  .  ..  .||||  | ||||....|  ..    .|  ........ .|. |.. |.... . |
eregiqylhlpwpDhgvpdll..ellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpgavpnpgqlrf

TYE
 .|
Lle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 737-844 2.3e-09 31.4 In-house 215-344 (350) alignment
Range on Protein: 737-844
Range on HMM: 215-344/350.0
HTVTQYQFHGWPKHGSDQQPGA--RSLM---KLIRA--VKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIA------QIAEG---------DSVDIFQ
. | | |.. |.  .   .|    ..|    .||     .|  ....  .||||| .| ||||...|    .       .. .              |..
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

TVKILRADRMQFVQTEEEYAFTYEVIREYL
.|..||  |.. ||. . . | || .. | 
ivnelrkqrismvqnldqfifiYeallfyf

PTPc_DSPc_SM00012 738-841 1.4e-27 91.3 In-house 1-104 (105) alignment
Range on Protein: 738-841
Range on HMM: 1-104/105.0
TVTQYQFHGWPKHGSDQQPgaRSLMKLIRAVKSSTNKKKE-FSILVHCLSGSGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAF
||..|...|||.||  ...   |...|.||||...||...  ...|||  | ||||.|...  .. |. .. ..|||||.|| ||  |.. |||||.| |
tvkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylf

TYEVIR
 |... 
lyrall

0038934 (Phosphotyrosine protein) phosphatases II 742-796 2e-07 26.4 In-house 80-134 (194) alignment
Range on Protein: 742-796
Range on HMM: 80-134/194.0
YQFHGWPKHGSDQQPGARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCT
.... .|  .    |    |.. ...|.  .|....  ..|||  | ||||... 
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva

subfamily_CG42327_pd Subfamily CG42327 753-843 1.7e-13 45.0 In-house 222-314 (319) alignment
Range on Protein: 753-843
Range on HMM: 222-314/319.0
DQQPGARSLMKLIRAVKSST-NKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEG-DSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREY
  . |. |  ..   . | . ....   . |||  | ||||.  ..   | .. |   |||| |.|  .| || . |.| | |.| | |. ||
kaeagstssheingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_PTPDC1_pd Subfamily PTPDC1 757-837 6.5e-06 20.7 In-house 94-169 (182) alignment
Range on Protein: 757-837
Range on HMM: 94-169/182.0
GARSLMKLIRAVKSSTNKKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDsvdifQTVKILRADRMQFVQTEEEYAFTY
|..|| ...  ||  .   .|  . ||| .| |||||  ...   |.  ...     ...|..|. | . .|| |   .  
gvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltae.....kaiklvrskrpksiqtreqvelvk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 774-840 1.9e-09 31.8 In-house 225-291 (297) alignment
Range on Protein: 774-840
Range on HMM: 225-291/297.0
KKKEFSILVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVI
. ..  .|||| .| ||.||   ..  .|..  .   |.   ..|||  | . ||| |.. . |...
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 781-844 1.1e-11 39.0 In-house 2-65 (69) alignment
Range on Protein: 781-844
Range on HMM: 2-65/69.0
LVHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
.||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  | || | .. . | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 782-844 8.6e-12 39.2 In-house 2-64 (69) alignment
Range on Protein: 782-844
Range on HMM: 2-64/69.0
VHCLSGSGRTGVFCTAMECIAQIAEGDSVDIFQTVKILRADRMQFVQTEEEYAFTYEVIREYL
||| ||.|||| | . |  .|.|     ||||  |. .|  |   |  |.|| | .. . | |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal